Gene Symbol: THAP10
Description: THAP domain containing 10
Alias: THAP domain-containing protein 10
Species: human
Products:     THAP10

Top Publications

  1. Sanghavi H, Mallajosyula S, Majumdar S. Classification of the human THAP protein family identifies an evolutionarily conserved coiled coil region. BMC Struct Biol. 2019;19:4 pubmed publisher
    ..the strong possibility of coiled coil formation in this conserved, leucine rich region of all THAP proteins except THAP10. The identification of a predicted oligomerization region in the human THAP protein family opens new directions to ..
  2. De Souza Santos E, De Bessa S, Netto M, Nagai M. Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer. Int J Oncol. 2008;33:25-31 pubmed
    ..The LRRC49 gene is located on chromosome 15q23 in close proximity to the THAP10 (THAP domain containing 10) gene...
  3. Roussigne M, Kossida S, Lavigne A, Clouaire T, Ecochard V, Glories A, et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem Sci. 2003;28:66-9 pubmed
    ..Our results suggest that the THAP domain is a novel example of a DBD that is shared between cellular proteins and transposases from mobile genomic parasites. ..
  4. Li Y, Ning Q, Shi J, Chen Y, Jiang M, Gao L, et al. A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis. EMBO Mol Med. 2017;9:933-949 pubmed publisher
    ..This study demonstrated that a novel hypermethylated zinc finger-containing protein, THAP10, is a target gene and can be epigenetically suppressed by AML1-ETO at the transcriptional level in t(8;21) AML...