THADA

Summary

Gene Symbol: THADA
Description: THADA, armadillo repeat containing
Alias: ARMC13, GITA, thyroid adenoma-associated protein, death receptor-interacting protein, gene inducing thyroid adenomas protein
Species: human
Products:     THADA

Top Publications

  1. Stancakova A, Kuulasmaa T, Paananen J, Jackson A, Bonnycastle L, Collins F, et al. Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes. 2009;58:2129-36 pubmed publisher
    ..near PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, LOC387761, CDKN2B, IGF2BP2, CDKAL1, HNF1B, WFS1, JAZF1, CDC123, TSPAN8, THADA, ADAMTS9, NOTCH2, KCNQ1, and MTNR1B were performed...
  2. Grarup N, Andersen G, Krarup N, Albrechtsen A, Schmitz O, Jørgensen T, et al. Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D. Diabetes. 2008;57:2534-40 pubmed publisher
    ..novel type 2 diabetes-associated variants in the JAZF1 (rs864745), CDC123/CAMK1D (rs12779790), TSPAN8 (rs7961581), THADA (rs7578597), ADAMTS9 (rs4607103), and NOTCH2 (rs10923931) loci, which were recently identified by meta-analysis of ..
  3. Meigs J, Shrader P, Sullivan L, McAteer J, Fox C, Dupuis J, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med. 2008;359:2208-19 pubmed publisher
    ..A genotype score based on 18 risk alleles predicted new cases of diabetes in the community but provided only a slightly better prediction of risk than knowledge of common risk factors alone. ..
  4. Lango H, Palmer C, Morris A, Zeggini E, Hattersley A, McCarthy M, et al. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes. 2008;57:3129-35 pubmed publisher
    ..Further studies are needed to assess whether individuals with extreme numbers of risk alleles may benefit from genetic testing. ..
  5. Rippe V, Drieschner N, Meiboom M, Murua Escobar H, Bonk U, Belge G, et al. Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas. Oncogene. 2003;22:6111-4 pubmed
    ..cloning and 3' RACE-PCR allowed us to clone that gene which we will refer to as thyroid adenoma associated (THADA) gene. In cells from two thyroid adenomas characterized by translocations t(2;20;3) (p21;q11...
  6. Kang E, Kim M, Kim C, Nam C, Han S, Hur K, et al. Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea. Transplantation. 2009;88:693-8 pubmed publisher
    ..IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892...
  7. Hu C, Zhang R, Wang C, Wang J, Ma X, Lu J, et al. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS ONE. 2009;4:e7643 pubmed publisher
    ..0335 to 1.37E-12). But no significant association was detected between SNPs from WFS1, FTO, JAZF1, TSPAN8-LGR5, THADA, ADAMTS9, NOTCH2-ADAM30 and type 2 diabetes...
  8. Lin X, Song K, Lim N, Yuan X, Johnson T, Abderrahmani A, et al. Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. Diabetologia. 2009;52:600-8 pubmed publisher
    ..In this population, a simple weighted 15 SNP-based genetic score provides additional information over clinical predictors of prevalent diabetes. At this stage, however, the clinical benefit of this genetic information is limited. ..
  9. Sanghera D, Been L, Ortega L, Wander G, Mehra N, Aston C, et al. Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs. J Hum Genet. 2009;54:162-8 pubmed publisher
    A recent meta-analysis on three genome-wide association (GWA) scans identified six loci (NOTCH2, THADA, ADAMTS9, JAZF1, CDC123/CAMKID and TSPAN8/LGRS) highly associated with type II diabetes (T2D) in Caucasians...

More Information

Publications68

  1. Schleinitz D, Tonjes A, Bottcher Y, Dietrich K, Enigk B, Koriath M, et al. Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits. Horm Metab Res. 2010;42:14-22 pubmed publisher
    ..performed an association study of 9 SNPs in or around JAZF1, CDC123/ CAMK1D, NOTCH2, BCL11A, ADAMTS9, VEGFA, DCD, THADA, and TSPAN8/ LGR5 with T2D and related quantitative traits (fasting insulin and glucose, indices derived from OGTT)..
  2. Drieschner N, Belge G, Rippe V, Meiboom M, Loeschke S, Bullerdiek J. Evidence for a 3p25 breakpoint hot spot region in thyroid tumors of follicular origin. Thyroid. 2006;16:1091-6 pubmed
    ..Recently, we have been able to describe the involvement of a novel gene called THADA in benign thyroid lesions with 2p21 rearrangements...
  3. Zeggini E, Scott L, Saxena R, Voight B, Marchini J, Hu T, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40:638-45 pubmed publisher
    ..0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions...
  4. Zhao J, Bradfield J, Zhang H, Annaiah K, Wang K, Kim C, et al. Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI. Diabetes. 2010;59:751-5 pubmed publisher
    ..FTO, HHEX-IDE, IGF2BP2, the intragenic region on 11p12, JAZF1, KCNQ1, LOC387761, MTNR1B, NOTCH2, SLC30A8, TCF7L2, THADA, and TSPAN8-LGR5...
  5. Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008;359:2220-32 pubmed publisher
    ..The value of genetic factors increased with an increasing duration of follow-up. ..
  6. Staiger H, Machicao F, Kantartzis K, Schäfer S, Kirchhoff K, Guthoff M, et al. Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes. PLoS ONE. 2008;3:e3019 pubmed publisher
    ..candidate single nucleotide polymorphisms (SNPs) JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8/LGR5 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs10923931, DCD rs1153188, VEGFA rs9472138, and BCL11A rs10490072...
  7. Bol S, Belge G, Rippe V, Bullerdiek J. Molecular cytogenetic investigations define a subgroup of thyroid adenomas with 2p21 breakpoints clustered to a region of less than 450 kb. Cytogenet Cell Genet. 2001;95:189-91 pubmed
    ..These two cell lines and one additional primary tumor were used for FISH-studies with 18 BAC clones. All breakpoints were mapped to a cluster of about 450 kb. ..
  8. Simonis Bik A, Nijpels G, van Haeften T, Houwing Duistermaat J, Boomsma D, Reiling E, et al. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. Diabetes. 2010;59:293-301 pubmed publisher
    ..All subjects were genotyped for gene variants in JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, THADA, ADAMTS9, NOTCH2/ADAMS30, DCD, VEGFA, BCL11A, HNF1B, WFS1, and MTNR1B...
  9. Pool C, Walter V, Bann D, Goldenberg D, Broach J, Hennessy M, et al. Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Virchows Arch. 2019;474:341-351 pubmed publisher
    ..Specifically, the "BRAF-like" subtype was enriched in invasive FV-PTCs and tumors with BRAF V600E mutations. The "THADA-like" subtype was enriched in non-invasive tumors and those with rearrangements involving THADA...
  10. Christodoulou M, Avgeris M, Kokkinopoulou I, Maratou E, Mitrou P, Kontos C, et al. Blood-based analysis of type-2 diabetes mellitus susceptibility genes identifies specific transcript variants with deregulated expression and association with disease risk. Sci Rep. 2019;9:1512 pubmed publisher
    ..In patients, increased expression of CDK5 tv2, CDKN2A tv3 or THADA tv5 correlated positively with serum insulin levels, of CDK5 tv1 positively with % HbA1c levels, while in controls,..
  11. de Braekeleer M, Guéganic N, Tous C, Le Bris M, Basinko A, Morel F, et al. Breakpoint heterogeneity in (2;3)(p15-23;q26) translocations involving EVI1 in myeloid hemopathies. Blood Cells Mol Dis. 2015;54:160-3 pubmed publisher
    ..A 1.08Mb region in band 2p21 encompassing the MTA3, ZFP36L2 and THADA genes was documented in 5 patients. A second region of 1.83Mb in band 2p16.1 was identified in 8 patients...
  12. Bolognese A, Yang W, Hansen L, Denning N, Nicastro J, Coppa G, et al. Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis. Surgery. 2018;: pubmed publisher
    ..Targeting the necroptosis pathway might represent a new therapeutic strategy for neonatal sepsis. ..
  13. Hoppmann N, Graetz C, Paterka M, Poisa Beiro L, Larochelle C, Hasan M, et al. New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis. Brain. 2015;138:902-17 pubmed publisher
    ..distinct genes associated with multiple sclerosis risk, Bach2, Il2ra, Irf8, Mertk, Odf3b, Plek, Rgs1, Slc30a7 and Thada, can be confirmed to be differentially regulated in pathogenic CD4(+) T cells...
  14. Sun M, Sheng Y, Ma Z, Chen Z, Tang R. [Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes]. Zhonghua Fu Chan Ke Za Zhi. 2014;49:441-5 pubmed
    ..Three of PCOS susceptibility locus 2p16.3 (rs13405728 of LHCGR gene), 2p21 (rs13429458, rs12478601 of THADA gene) and 9q33...
  15. Raj S, Howson J, Walker N, Cooper J, Smyth D, Field S, et al. No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia. 2009;52:2109-16 pubmed publisher
    ..gene regions, PPARG, CDKAL1, HNF1B, WFS1, SLC30A8, CDKN2A-CDKN2B, IGF2BP2, KCNJ11, TCF7L2, FTO, HHEX-IDE and THADA, were analysed in type 1 diabetes cases and controls...
  16. Dziewulska A, Dobosz A, Dobrzyn A. High-Throughput Approaches onto Uncover (Epi)Genomic Architecture of Type 2 Diabetes. Genes (Basel). 2018;9: pubmed publisher
    ..Differentially methylated regions were found in TCF7L2, THADA, KCNQ1, TXNIP, SOCS3, SREBF1, and KLF14 loci that are related to T2D...
  17. Guy M, Phizicky E. Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes. RNA. 2015;21:61-74 pubmed publisher
    ..we provide evidence that Trm7 and Trm732 function is widely conserved throughout eukaryotes, since human FTSJ1 and THADA, respectively, complement growth defects of S...
  18. Brower M, Jones M, Rotter J, Krauss R, Legro R, Azziz R, et al. Further investigation in europeans of susceptibility variants for polycystic ovary syndrome discovered in genome-wide association studies of Chinese individuals. J Clin Endocrinol Metab. 2015;100:E182-6 pubmed publisher
    ..Variants in DENND1A (P = .0002), THADA (P = .035), FSHR (P = .007), and INSR (P = .046) were associated with PCOS in Europeans...
  19. Cui L, Li G, Zhong W, Bian Y, Su S, Sheng Y, et al. Polycystic ovary syndrome susceptibility single nucleotide polymorphisms in women with a single PCOS clinical feature. Hum Reprod. 2015;30:732-6 pubmed publisher
    ..001); variants in the thyroid adenoma associated gene (THADA) (rs13429458 and rs12478601), DENN/MADD domain containing 1A (DENND1A)(rs10818854), and C9orf3 (rs4385527) were ..
  20. Thomsen S, Ceroni A, van de Bunt M, Burrows C, Barrett A, Scharfmann R, et al. Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants. Diabetes. 2016;65:3805-3811 pubmed
    ..Selected effects were validated in a follow-up study, including several genes (ARL15, ZMIZ1, and THADA) with previously unknown or poorly described roles in β-cell biology...
  21. Klimentidis Y, Divers J, Casazza K, Beasley T, Allison D, Fernandez J. Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children. Hum Genomics. 2011;5:79-89 pubmed
    ..8 × 10(-5)). This marker may be in admixture linkage disequilibrium with nearby loci ( THADA and BCL11A ) that previously have been reported to be associated with diabetes and diabetes-related phenotypes in ..
  22. Kimura R, Watanabe C, Kawaguchi A, Kim Y, Park S, Maki K, et al. Common polymorphisms in WNT10A affect tooth morphology as well as hair shape. Hum Mol Genet. 2015;24:2673-80 pubmed publisher
    ..Previous association studies have confirmed that single-nucleotide polymorphisms (SNPs) in/near THADA, FRAS1, WNT10A, NAF1 and FGFR2 are associated with hair morphology...
  23. Lango Allen H, Johansson S, Ellard S, Shields B, Hertel J, Raeder H, et al. Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Diabetes. 2010;59:266-71 pubmed publisher
    ..This is one of the first studies to demonstrate that clinical characteristics of a monogenic disease can be modified by common polygenic variants. ..
  24. Cui L, Zhao H, Zhang B, Qu Z, Liu J, Liang X, et al. Genotype-phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women. Hum Reprod. 2013;28:538-44 pubmed publisher
    ..ovary syndrome (PCOS) and the genotypes of the PCOS susceptibility single nucleotide polymorphisms (SNPs) in THADA, DENND1A and LHCGR? The PCOS susceptibility genes, THADA and DENND1A, carry risk alleles that are associated with ..
  25. de Melo A, Dias S, Cavalli R, Cardoso V, Bettiol H, Barbieri M, et al. Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause. Reproduction. 2015;150:R11-24 pubmed publisher
    ..studies based on adequate population samples have shown a higher frequency of genetic polymorphisms of the LHCGR, THADA and DENND1A genes in women with PCOS...
  26. Sun J, Kader A, Hsu F, Kim S, Zhu Y, Turner A, et al. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. Prostate. 2011;71:421-30 pubmed publisher
    ..Men identified as high risk by SNP-based testing may be targeted for PCa screening or chemoprevention. The clinical impact on improving the effectiveness of these interventions can be and should be assessed. ..
  27. Shi Y, Zhao H, Shi Y, Cao Y, Yang D, Li Z, et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet. 2012;44:1020-5 pubmed publisher
    ..Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS. ..
  28. Bai H, Liu H, Suyalatu S, Guo X, Chu S, Chen Y, et al. Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China. J Diabetes Res. 2015;2015:613236 pubmed publisher
    ..replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), ..
  29. Ha L, Shi Y, Zhao J, Li T, Chen Z. Association Study between Polycystic Ovarian Syndrome and the Susceptibility Genes Polymorphisms in Hui Chinese Women. PLoS ONE. 2015;10:e0126505 pubmed publisher
    ..Our previous research had identified three susceptibility loci (rs2479106, DENND1A; rs13405728, LHCGR; rs13429458, THADA) for PCOS in Han Chinese women...
  30. Panebianco F, Kelly L, Liu P, Zhong S, Dacic S, Wang X, et al. THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. Proc Natl Acad Sci U S A. 2017;114:2307-2312 pubmed publisher
    ..and whole-genome analyses, we identified a recurrent fusion between the thyroid adenoma-associated (THADA) gene on chromosome 2 and the LOC389473 gene on chromosome 7 located 12 kb upstream of the IGF2BP3
  31. Moraru A, Cakan Akdogan G, Strassburger K, Males M, Mueller S, Jabs M, et al. THADA Regulates the Organismal Balance between Energy Storage and Heat Production. Dev Cell. 2017;41:72-81.e6 pubmed publisher
    ..We uncover here the function of a gene that supports this theory. THADA is one of the genes most strongly selected during evolution as humans settled in different climates...
  32. Zhao F, Xu Y, Yang K, Liu M, Wei D, Zhang Y, et al. THADA gene polymorphism and prostate cancer risk: a meta-analysis. Oncol Res Treat. 2014;37:106-10 pubmed publisher
    The single nucleotide polymorphism (SNP) rs1465618 in THADA at 2p21 has been identified as being associated with prostate cancer (PCa) risk in Europeans; however, it is not clear whether the SNP is related to PCa risk in multiple ..
  33. Eeles R, Kote Jarai Z, Al Olama A, Giles G, Guy M, Severi G, et al. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009;41:1116-21 pubmed publisher
    ..In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)). ..
  34. Talmud P, Hingorani A, Cooper J, Marmot M, Brunner E, Kumari M, et al. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ. 2010;340:b4838 pubmed publisher
  35. Prasad R, Lessmark A, Almgren P, Kovacs G, Hansson O, Oskolkov N, et al. Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes. Diabetologia. 2016;59:1702-13 pubmed publisher
    ..037), which can be considered positive controls. The strongest POE was seen for rs7578597 SNP in the THADA gene, showing excess transmission of the maternal risk allele T to diabetic offspring (Botnia: p POE  =â€..
  36. López S, Buil A, Souto J, Casademont J, Martinez Perez A, Almasy L, et al. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. Mitochondrion. 2014;18:34-40 pubmed publisher
    ..Both genes have a role in mitochondrial biogenesis and are potential candidates for the sex-specific control of mtDNA levels. ..
  37. Nitert M, Dayeh T, Volkov P, Elgzyri T, Hall E, Nilsson E, et al. Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes. 2012;61:3322-32 pubmed publisher
    ..pathways (P < 3 × 10(-6)) and with known functions in muscle and T2D including MEF2A, RUNX1, NDUFC2, and THADA decreased after exercise. Methylation of these human promoter regions suppressed reporter gene expression in vitro...
  38. Chen L, Hu L, Wang Y, Yang H, Huang X, Zhou W, et al. Genome-wide association study for SNPs associated with PCOS in human patients. Exp Ther Med. 2017;14:4896-4900 pubmed publisher
    ..05): rs346795081 on THADA, rs346803513 on DENND1A and rs346999236 on TOX3...
  39. Saxena R, Georgopoulos N, Braaten T, Bjonnes A, Koika V, Panidis D, et al. Han Chinese polycystic ovary syndrome risk variants in women of European ancestry: relationship to FSH levels and glucose tolerance. Hum Reprod. 2015;30:1454-9 pubmed publisher
    ..were also associated with PCOS in at least one European population when corrected for multiple testing (DENND1A, THADA and YAP1)...
  40. Kim S, Cheng Y, Hsu F, Jin T, Kader A, Zheng S, et al. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. Prostate. 2010;70:1729-38 pubmed publisher
    ..These SNPs explain a considerable proportion of genetic variance, however, the majority of genetic variance has yet to be explained. ..
  41. Day F, Hinds D, Tung J, Stolk L, Styrkarsdottir U, Saxena R, et al. Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. Nat Commun. 2015;6:8464 pubmed publisher
    ..signals for PCOS at genome-wide statistical significance (P<5 × 10(-8)), in/near genes ERBB4/HER4, YAP1, THADA, FSHB, RAD50 and KRR1...
  42. Medland S, Nyholt D, Painter J, McEvoy B, McRae A, Zhu G, et al. Common variants in the trichohyalin gene are associated with straight hair in Europeans. Am J Hum Genet. 2009;85:750-5 pubmed publisher
    ..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations. ..
  43. Chatterjee N, Perrimon N. Thermogenesis by THADA. Dev Cell. 2017;41:1-2 pubmed publisher
    b>THADA has been associated with cold adaptation and diabetes in humans, but the cellular and molecular basis of its function has been unknown...
  44. Hung Y, Barletta J. A user's guide to non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Histopathology. 2018;72:53-69 pubmed publisher
    ..mutations, although rarely other alterations, such as the BRAF K601E mutation and gene rearrangements in PPARG or THADA, may occur...
  45. Kloth L, Belge G, Burchardt K, Loeschke S, Wosniok W, Fu X, et al. Decrease in thyroid adenoma associated (THADA) expression is a marker of dedifferentiation of thyroid tissue. BMC Clin Pathol. 2011;11:13 pubmed publisher
    Thyroid adenoma associated (THADA) has been identified as the target gene affected by chromosome 2p21 translocations in thyroid adenomas, but the role of THADA in the thyroid is still elusive...
  46. Schulze M, Weikert C, Pischon T, Bergmann M, Al Hasani H, Schleicher E, et al. Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study. Diabetes Care. 2009;32:2116-9 pubmed publisher
    ..002). Twenty SNPs did not improve discrimination beyond these characteristics (P = 0.69). Metabolic markers, but not genotyping for 20 diabetogenic SNPs, improve discrimination of incident type 2 diabetes beyond lifestyle risk factors. ..
  47. Beaty T, Taub M, Scott A, Murray J, Marazita M, Schwender H, et al. Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. Hum Genet. 2013;132:771-81 pubmed publisher
    ..In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and association in this ..
  48. Saxena R, Welt C. Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes. Acta Diabetol. 2013;50:451-7 pubmed publisher
    ..T2D variants were associated with PCOS phenotype parameters including those in THADA and WFS1 with testosterone levels, ENPP/PC1 with triglyceride levels, FTO with glucose levels and KCNJ11 with FSH ..
  49. Mangold E, Ludwig K, Birnbaum S, Baluardo C, Ferrian M, Herms S, et al. Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. Nat Genet. 2010;42:24-6 pubmed publisher
    ..07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56). ..
  50. Rentería M, Coolen M, Statham A, Choi R, Qu W, Campbell M, et al. GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association. Twin Res Hum Genet. 2013;16:767-81 pubmed publisher
    ..Nevertheless, these associations will require future experimental validation or replication in larger and independent samples. ..
  51. Li X, Xu Y, Yang K, Shi J, Zhang X, Yang F, et al. Association of THADA, FOXP4, GPRC6A/RFX6 genes and 8q24 risk alleles with prostate cancer in Northern Chinese men. J BUON. 2015;20:1223-8 pubmed
    ..17, p=0.486). Our results provide further support for association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with Pca in Asian populations...
  52. Lyssenko V, Groop L, Prasad R. Genetics of Type 2 Diabetes: It Matters From Which Parent We Inherit the Risk. Rev Diabet Stud. 2015;12:233-42 pubmed publisher
    ..Such PoO transmission is seen for variants in the KLF14, KCNQ1, GRB10, TCF7L2, THADA, and PEG3 genes...
  53. Goodarzi M, Jones M, Li X, Chua A, Garcia O, Chen Y, et al. Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts. J Med Genet. 2012;49:90-5 pubmed publisher
    ..3 (luteinising hormone/choriogonadotropin receptor; LHCGR), 2p21 (thyroid associated protein; THADA), and 9q33.3 (DENN/MADD domain containing 1A; DENNDIA)...
  54. Ludwig K, Mangold E, Herms S, Nowak S, Reutter H, Paul A, et al. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet. 2012;44:968-71 pubmed publisher
    ..51 × 10(-11); homozygote relative risk = 2.41, 95% confidence interval (CI) 1.84-3.16). ..
  55. Chen Z, Zhao H, He L, Shi Y, Qin Y, Shi Y, et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet. 2011;43:55-9 pubmed publisher
    ..73 × 10?²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10?¹?, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended. ..
  56. Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, et al. Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol. 2009;170:537-45 pubmed publisher
    ..Information on the genetic model of robustly replicated association signals derived from genome-wide association studies may be useful for predictive modeling and for designing biologic and functional experiments. ..
  57. Gupta V, Vinay D, Sovio U, Rafiq S, Kranthi Kumar M, Janipalli C, et al. Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs. PLoS ONE. 2013;8:e53944 pubmed publisher
    ..marginal evidence of associations between variants at six loci (TCF7L2, NGN3, FOXA2, LOC646279, FLJ39370 and THADA) and waist hip ratio (WHR), BMI and/or overweight which needs to be validated in larger set of samples...
  58. Brito E, Lyssenko V, Renstrom F, Berglund G, Nilsson P, Groop L, et al. Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. Diabetes. 2009;58:1411-8 pubmed publisher
    ..015 and 0.0068, respectively). Our observations suggest that the genetic predisposition to hyperglycemia is partially dependent on a person's lifestyle. ..
  59. Zia A, Bhatti A, John P, Kiani A. Data interpretation: deciphering the biological function of Type 2 diabetes associated risk loci. Acta Diabetol. 2015;52:789-800 pubmed publisher
    ..with RegulomeDB score <3 (evidence of regulatory function), and only four of these were GWAS significant SNPs (THADA/rs10203174, score = 1b; UBE2E2/rs7612463, score = 2a; ARAP1/rs1552224 and TP53INP1/rs8996852, score = 2b)...