TGM1

Summary

Gene Symbol: TGM1
Description: transglutaminase 1
Alias: ARCI1, ICR2, KTG, LI1, TGASE, TGK, K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase, TG(K), TGase K, TGase-1, epidermal TGase, protein-glutamine gamma-glutamyltransferase K, transglutaminase 1 isoform, transglutaminase K, transglutaminase, keratinocyte, transglutaminase-1
Species: human

Top Publications

  1. ncbi Mutations of keratinocyte transglutaminase in lamellar ichthyosis
    M Huber
    Department of Dermatology, Centre Hospitalier Universitaire Vandois CHUV, Hôpital de Beaumont, Lausanne, Switzerland
    Science 267:525-8. 1995
  2. ncbi Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis
    L J Russell
    Genetic Studies Section, National Institute of Arthritis and Musculoskeletal and Skin Disease, NIH, Bethesda, Maryland 20892 2757, USA
    Nat Genet 9:279-83. 1995
  3. pmc Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1
    Matthew L Herman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland 20892 4562, USA
    Hum Mutat 30:537-47. 2009
  4. ncbi Strong founder effect for a transglutaminase 1 gene mutation in lamellar ichthyosis and congenital ichthyosiform erythroderma from Norway
    M Pigg
    Department of Genetics and Pathology, University Hospital, Uppsala, Sweden
    Eur J Hum Genet 6:589-96. 1998
  5. ncbi Splice-site mutation in TGM1 in congenital recessive ichthyosis in American families: molecular, genetic, genealogic, and clinical studies
    Y O Shevchenko
    Genetic Studies Section, Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD 20892 2757, USA
    Hum Genet 106:492-9. 2000
  6. ncbi Structure and organization of the human transglutaminase 1 gene
    I G Kim
    Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:7710-7. 1992
  7. ncbi The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes
    P M Steinert
    Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 2755, USA
    J Biol Chem 271:26242-50. 1996
  8. ncbi Three novel point mutations in the keratinocyte transglutaminase (TGK) gene in lamellar ichthyosis: significance for mutant transcript level, TGK immunodetection and activity
    E Petit
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Eur J Hum Genet 5:218-28. 1997
  9. doi Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients
    Anders Vahlquist
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 130:438-43. 2010
  10. ncbi Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin
    E Candi
    Laboratory of Skin Biology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892 2752, USA
    J Biol Chem 274:7226-37. 1999

Detail Information

Publications190 found, 100 shown here

  1. ncbi Mutations of keratinocyte transglutaminase in lamellar ichthyosis
    M Huber
    Department of Dermatology, Centre Hospitalier Universitaire Vandois CHUV, Hôpital de Beaumont, Lausanne, Switzerland
    Science 267:525-8. 1995
    ..Affected individuals in three families exhibited drastically reduced keratinocyte transglutaminase (TGK) activity...
  2. ncbi Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis
    L J Russell
    Genetic Studies Section, National Institute of Arthritis and Musculoskeletal and Skin Disease, NIH, Bethesda, Maryland 20892 2757, USA
    Nat Genet 9:279-83. 1995
    ..lamellar ichthyosis (LI) to chromosome 14q11 and showed complete linkage with TGM1, the gene encoding transglutaminase 1. We have now identified point mutations in TGM1 in two of the multiplex LI families used in the linkage ..
  3. pmc Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1
    Matthew L Herman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland 20892 4562, USA
    Hum Mutat 30:537-47. 2009
    ..Germline mutations in TGM1 are the most common cause of ARCI in the United States. TGM1 encodes for the TGase-1 enzyme that functions in the formation of the cornified cell envelope...
  4. ncbi Strong founder effect for a transglutaminase 1 gene mutation in lamellar ichthyosis and congenital ichthyosiform erythroderma from Norway
    M Pigg
    Department of Genetics and Pathology, University Hospital, Uppsala, Sweden
    Eur J Hum Genet 6:589-96. 1998
    ..It was recently shown that mutations in the transglutaminase 1 (TGM1) gene may be associated with the clinical subtypes lamellar ichthyosis (LI) and non-bullous congenital ..
  5. ncbi Splice-site mutation in TGM1 in congenital recessive ichthyosis in American families: molecular, genetic, genealogic, and clinical studies
    Y O Shevchenko
    Genetic Studies Section, Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD 20892 2757, USA
    Hum Genet 106:492-9. 2000
    ..Mutations in the gene for transglutaminase-1 (TGM1) are responsible for many cases of LI and occur throughout the coding sequence of the gene...
  6. ncbi Structure and organization of the human transglutaminase 1 gene
    I G Kim
    Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:7710-7. 1992
    ..In order to determine the complexity of this system, we have isolated and characterized the human gene (TGM1). The gene of 14,133 base pairs was found to contain 15 exons spliced by 14 introns...
  7. ncbi The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes
    P M Steinert
    Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 2755, USA
    J Biol Chem 271:26242-50. 1996
    The transglutaminase 1 (TGase 1) enzyme is involved in the formation of a cornified cell envelope in terminally differentiating epidermal keratinocytes...
  8. ncbi Three novel point mutations in the keratinocyte transglutaminase (TGK) gene in lamellar ichthyosis: significance for mutant transcript level, TGK immunodetection and activity
    E Petit
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Eur J Hum Genet 5:218-28. 1997
    ..patients from 7 unrelated families with lamellar ichthyosis (LI) for defects in the keratinocyte transglutaminase (TGK) gene...
  9. doi Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients
    Anders Vahlquist
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 130:438-43. 2010
    ..Mutations in two genes, TGM1 and ALOX12B, have previously been implicated in the etiology of SHCB, but the full genotypic spectrum remains to be ..
  10. ncbi Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin
    E Candi
    Laboratory of Skin Biology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892 2752, USA
    J Biol Chem 274:7226-37. 1999
    ..for cross-linking by TGase 3, whereas those in head domain B sequences were used for cross-linking by TGase 1. The TGase 2 enzyme cross-linked SPR1 proteins poorly...
  11. pmc An ERp60-like protein from the filarial parasite Dirofilaria immitis has both transglutaminase and protein disulfide isomerase activity
    R Chandrashekar
    Heska Corporation, Fort Collins, CO 80525, USA
    Proc Natl Acad Sci U S A 95:531-6. 1998
    ..the presence of isopeptide bonds in the sheath and cuticle of filarial parasites, suggesting an important role for TGase-catalyzed reactions during the growth and development of filarial nematodes...
  12. ncbi Formation of cornified cell envelope in human hair follicle development
    M Akiyama
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita ku, Sapporo 060 8638, Japan
    Br J Dermatol 146:968-76. 2002
    ....
  13. doi Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments
    Stefano Del Duca
    Dipartimento di Biologia Evoluzionistica Sperimentale, Sede Botanica, University of Bologna, Via Irnerio 42, Bologna, Italy
    Biochem J 418:651-64. 2009
    ..To assess the activity of apple (Malus domestica) pollen TGase on the functional properties of actin and tubulin, TGase was prepared from apple pollen by hydrophobic- ..
  14. doi An in situ and in vitro investigation for the transglutaminase potential in tissue engineering
    D I Zeugolis
    Tissue Modulation Laboratory, National University of Singapore, Singapore
    J Biomed Mater Res A 92:1310-20. 2010
    ..The role of tissue transglutaminase (TGase 2) in several pathophysiologies, wound healing applications, biomaterials functionalization, and drug delivery ..
  15. ncbi Sporadic inclusion body myositis correlates with increased expression and cross-linking by transglutaminases 1 and 2
    Y C Choi
    Department of Neurology, College of Medicine, Yonsei University, Seoul 135 270, Republic of Korea
    J Biol Chem 275:8703-10. 2000
    ..We report that at least two different enzymes, the ubiquitous TGase 2 as well as the TGase 1 enzyme, are present in muscle tissues...
  16. pmc Transglutaminase activity in the hematopoietic tissue of a crustacean, Pacifastacus leniusculus, importance in hemocyte homeostasis
    Xionghui Lin
    Department of Comparative Physiology, Uppsala University, Norbyvagen 18A, SE 752 36 Uppsala, Sweden
    BMC Immunol 9:58. 2008
    ..We also found that TGase is an abundant protein in the hematopoietic tissue (Hpt) cells of crayfish and hence we have studied the possible ..
  17. ncbi Transglutaminases - possible drug targets in human diseases
    Vittorio Gentile
    Department of Biochemistry and Biophysics, Medical School, Second University of Naples, Naples, Italy
    Curr Drug Targets CNS Neurol Disord 3:99-104. 2004
    ..disease (PD), supranuclear palsy and Huntington disease (HD), are characterized in part by aberrant cerebral TGase activity and by increased cross-linked proteins in affected brain...
  18. pmc Tissue transglutaminase acylation: Proposed role of conserved active site Tyr and Trp residues revealed by molecular modeling of peptide substrate binding
    Roberto A Chica
    Departement de Chimie, Universite de Montreal, 2900 Edouard Montpetit, Montreal, Quebec, Canada H3C 3J7
    Protein Sci 13:979-91. 2004
    ..Given the implication of tissue TGase in various physiological disorders, development of specific tissue TGase inhibitors is of current interest...
  19. pmc Increased levels of gamma-glutamylamines in Huntington disease CSF
    Thomas M Jeitner
    Red Anvil, LLC, Milwaukee, Wisconsin, USA
    J Neurochem 106:37-44. 2008
    ..The resulting gamma-glutamylamines are excised intact during proteolysis. TGase activity is altered in several diseases, highlighting the importance of in situ enzymatic determinations...
  20. ncbi Kinetin affects the level of chloroplast polyamines and transglutaminase activity during senescence of barley leaves
    Ewa Sobieszczuk-Nowicka
    Department of Plant Physiology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland
    Acta Biochim Pol 56:255-9. 2009
    ..Immunodetection of transglutaminases (TGase) in thylakoid fraction revealed three bands of 33, 58 and 78 kDa...
  21. doi Activity of maize transglutaminase overexpressed in Escherichia coli inclusion bodies: an alternative to protein refolding
    Patricia Carvajal
    Dept of Molecular Genetics, Centre de Recerca Agrigenomica CRAG CSIC IRTA UAB, Jordi Girona Salgado 18 24, 08034 Barcelona, Spain
    Biotechnol Prog 27:232-40. 2011
    ..In plants, this enzyme is poorly characterized and only the maize plastidial TGase gene (tgz) has been cloned...
  22. ncbi The emerging structural understanding of transglutaminase 3
    Bijan Ahvazi
    X ray Crystallography Facility, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 8023, USA
    J Struct Biol 147:200-7. 2004
    Transglutaminases (TGase; protein-glutamine: amine gamma-glutamyl-transferase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between ..
  23. ncbi Differential expression of multiple transglutaminases in human brain. Increased expression and cross-linking by transglutaminases 1 and 2 in Alzheimer's disease
    S Y Kim
    Laboratory of Skin Biology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:30715-21. 1999
    ..chain reaction and immunological methods with specific antibodies that in fact three members, the TGase 1, TGase 2, and TGase 3 enzymes, and are differentially expressed in various regions of normal human brain tissues...
  24. ncbi Identification of the eukaryotic initiation factor 5A as a retinoic acid-stimulated cellular binding partner for tissue transglutaminase II
    U S Singh
    Department of Pharmacology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 273:1946-50. 1998
    ..essential for cell viability, perhaps through effects on protein synthesis and/or RNA export, associates with the TGase in vivo...
  25. ncbi Recent patents on transglutaminase production and applications: a brief review
    Mireya Santos
    Centre of Research in Agrogenomics CRAG CSIC IRTA UAB, Department of Molecular Genetics, Jordi Girona 18 24, 08034 Barcelona, Spain
    Recent Pat Biotechnol 3:166-74. 2009
    The transglutaminases (TGase; EC2.3.2...
  26. doi Remodeling of tobacco thylakoids by over-expression of maize plastidial transglutaminase
    Nikolaos E Ioannidis
    Department of Biology, University of Crete, Crete, Greece
    Biochim Biophys Acta 1787:1215-22. 2009
    ..Here we report the effect of the over-expression of maize (Zea mays) chloroplast TGase in tobacco (Nicotiana tabacum var. Petit Havana) chloroplasts...
  27. ncbi Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro
    E Candi
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricerca e Cura a Carattere Scientifico, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Biol Chem 276:35014-23. 2001
    ..A new member of the TGase family, TGase 5, has been identified recently, and in the present study we evaluated its role in keratinocyte ..
  28. ncbi Cross linking of polyglutamine domains catalyzed by tissue transglutaminase is greatly favored with pathological-length repeats: does transglutaminase activity play a role in (CAG)(n)/Q(n)-expansion diseases?
    Arthur J L Cooper
    Department of Biochemistry, Weill Medical College of Cornell University, New York, NY, USA
    Neurochem Int 40:53-67. 2002
    ..three Ca(2+)-dependent enzymes (transglutaminases, TGases) that catalyze protein cross-linking reactions, namely TGase 1, TGase 2 (tissue transglutaminase, tTGase) and TGase 3...
  29. doi Transglutaminase-3 enzyme: a putative actor in human hair shaft scaffolding?
    Sebastien Thibaut
    L Oreal Recherche, Clichy, France
    J Invest Dermatol 129:449-59. 2009
    The family of transglutaminases (TGase) is known to be involved in terminal differentiation processes in the epidermis. These enzymes contribute also to the physical resistance and the preservation of the hair follicle structure...
  30. pmc Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase
    H J Dubbink
    Department of Urology, Erasmus University, Rotterdam, The Netherlands
    Biochem J 315:901-8. 1996
    ..In the prostate at least two TGases are present, the ubiquitously expressed tissue-type TGase (TGC), and a prostate-restricted TGase (TGP)...
  31. ncbi Chondrocyte-derived transglutaminase promotes maturation of preosteoblasts in periosteal bone
    Maria Nurminskaya
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Dev Biol 263:139-52. 2003
    ..One factor is TGase. In the cocultures, inhibition of TGase reduces mineralization, and addition of the enzyme enhances it...
  32. ncbi Substrate specificity of streptomyces transglutaminases
    James Langston
    Novozymes, Inc, 1445 Drew Avenue, Davis, CA 95616, USA
    Appl Biochem Biotechnol 136:291-308. 2007
    Transglutaminase (TGase) is a multifunctional enzyme vital for many physiologic processes, such as cell differentiation, tissue regeneration, and plant pathogenicity...
  33. ncbi Comparison of substrate specificities of transglutaminases using synthetic peptides as acyl donors
    T Ohtsuka
    Food Research and Development Laboratories, Ajinomoto Co, Inc, Kawasaki shi, Japan
    Biosci Biotechnol Biochem 64:2608-13. 2000
    Transglutaminase (TGase) is an enzyme that catalyzes acyl transfer reactions between primary amines and Gln residues in proteins or peptides...
  34. doi Cinnamoyl inhibitors of tissue transglutaminase
    Christophe Pardin
    Departement de Chimie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Org Chem 73:5766-75. 2008
    ..Unregulated, high TGase activities have been implicated in several physiological disorders, but few reversible inhibitors of TG2 have been ..
  35. ncbi Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription-polymerase chain reaction with degenerate primers
    D Aeschlimann
    Division of Orthopedic Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Biol Chem 273:3452-60. 1998
    ..We demonstrate amplification of tissue transglutaminase (TGC), keratinocyte transglutaminase (TGK), prostate transglutaminase (TGP), the a-subunit of factor XIII, and band 4...
  36. pmc Squamous metaplasia induced by transfection of human papillomavirus DNA into cultured adenocarcinoma cells
    T Kinjo
    Department of Pathology, Ryukyu University School of Medicine, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Mol Pathol 56:97-108. 2003
    ..In this present study, the effects of HPV transfection into adenocarcinoma cells were examined. The relation between the region expressing the HPV gene and squamous metaplasia was also studied...
  37. doi Dietary glucosylceramide enhances cornified envelope formation via transglutaminase expression and involucrin production
    Tatsuya Hasegawa
    Shiseido Functional Food Research and Development Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Lipids 46:529-35. 2011
    ..The GlcCer treatment also increased the level of TGase-1 mRNA in UVB-irradiated murine epidermis approximately 1.6-fold compared with the control...
  38. ncbi GTP, an inhibitor of transglutaminases, is hydrolyzed by tissue-type transglutaminase (TGase 2) but not by epidermal-type transglutaminase (TGase 3)
    K Hitomi
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Japan
    Biosci Biotechnol Biochem 64:657-9. 2000
    Epidermal-type transglutaminase (TGase 3) is devoid of GTPase activity, but its TGase activity is inhibited by GTP as in the case of tissue-type TGase (TGase 2)...
  39. ncbi Transglutaminase 5 is acetylated at the N-terminal end
    A Rufini
    Biochemistry Laboratory, IDI IRCCS, University of Rome Tor Vergata, Rome, Italy
    Amino Acids 26:425-30. 2004
    ..and a partial biochemical characterisation showed its involvement in skin differentiation, in parallel to TGase 1 and TGase 3...
  40. doi Transglutaminases in vascular biology: relevance for vascular remodeling and atherosclerosis
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands
    J Vasc Res 45:271-8. 2008
    The transglutaminase (Tgase) family consists of nine known members of whom at least three are expressed in the vascular system: type 1 Tgase, type 2 Tgase and factor XIII...
  41. doi Novel role of transglutaminase 1 in corpora amylacea formation?
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, VU University Medical Center, Neuroscience Campus Amsterdam, The Netherlands
    Neurobiol Aging 32:845-56. 2011
    ..We propose that TG1-catalyzed cross-linking and consequent polymerization of cytoskeletal and cytoskeleton-associated proteins may underlie CA formation...
  42. ncbi Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia
    Riccardo Ientile
    Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy
    Neurosci Lett 363:173-7. 2004
    ..RT-PCR demonstrated the presence of significant mRNA amounts of transglutaminase 2 and transglutaminase 1, both in the hippocampus and the cerebral cortex, while low levels were found for transglutaminase 3 ..
  43. ncbi Triggered psoriasis
    R Wolf
    Department of Dermatology, Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel
    Adv Exp Med Biol 455:221-5. 1999
    ..The chemical structure of the antimalarials is very similar to dansylputrescine, a potent transglutaminase (TGase) inhibitor...
  44. ncbi Basis for the permeability barrier abnormality in lamellar ichthyosis
    Peter M Elias
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Exp Dermatol 11:248-56. 2002
    ..LI is caused by mutations in the gene that encodes the enzyme, transglutaminase 1 (TGI), which is responsible for assembly of the cornified envelope (CE)...
  45. ncbi Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation
    Friederike Egberts
    Department of Dermatology, University Hospital of Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    J Cell Sci 117:2295-307. 2004
    ..Treatment of cultured keratinocytes with exogenous cathepsin D increased the activity of transglutaminase 1, known to cross-link the cornified envelope proteins involucrin and loricrin during epidermal ..
  46. ncbi Functional changes and motility characteristics of Japanese Black bull spermatozoa separated by Percoll
    K Suzuki
    Tohoku National Agricultural Experiment Station, Morioka 020 0123, Japan
    Anim Reprod Sci 77:157-72. 2003
    Spermatozoa from two Japanese Black bulls (Bull-ATF and Bull-KTG) were separated by centrifugation at 700 x g for 15min in modified TALP with or without 45-90% Percoll...
  47. pmc Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae
    K Ubukata
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morookacho, Kohoku Ku, Yokohama, Japan
    Antimicrob Agents Chemother 45:1693-9. 2001
    ..His-517, near the conserved Lys-Thr-Gly (KTG) motif, was substituted for Arg-517 in group I strains (n = 9), and Lys-526 was substituted for Asn-526 in group II ..
  48. doi Epigenetics, genomic imprinting and assisted reproductive technology
    Y Le Bouc
    Explorations Fonctionnelles Endocriniennes, Hopital d Enfants Armand Trousseau, AP HP, 75571 Paris, France
    Ann Endocrinol (Paris) 71:237-8. 2010
    ..methylation at the 11p15 imprinted locus [5-7]: respectively loss of methylation at the Imprinting Region Center (ICR2) or gain of methylation at ICR1 in BWS and loss of methylation at ICR1 in SRS...
  49. ncbi A novel homozygous mutation 371delA in TGM1 leads to a classic lamellar ichthyosis phenotype
    M Akiyama
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita ku, Sapporo 060 8638, Japan
    Br J Dermatol 148:149-53. 2003
    ..Immunofluorescence labelling with anti-TGase 1 antibodies was negative in the patient's epidermis...
  50. ncbi Cross-linked envelopes in nail plate in lamellar ichthyosis
    R H Rice
    Department of Environmental Toxicology, University of California, Davis, CA 95616 8588, USA
    Br J Dermatol 149:1050-4. 2003
    ..Defective CE formation occurs in epidermal scale and hair in transglutaminase 1 (TGM1)-negative lamellar ichthyosis (LI) and has been proposed as a diagnostic aid for this syndrome.
  51. doi Transglutaminase 1-deficient recessive lamellar ichthyosis associated with a LINE-1 insertion in Jack Russell terrier dogs
    K M Credille
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX, USA
    Br J Dermatol 161:265-72. 2009
    ..One cause of gene mutation important to humans and dogs is transposon insertions...
  52. pmc Transglutaminase1 preferred substrate peptide K5 is an efficient tool in diagnosis of lamellar ichthyosis
    Masashi Akiyama
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Am J Pathol 176:1592-9. 2010
    ..b>Transglutaminase 1 (TGase1) deficiency by TGase1 gene (TGM1) mutations is the most prevalent cause of LI...
  53. doi Acral self-healing collodion baby: report of a new clinical phenotype caused by a novel TGM1 mutation
    J Mazereeuw-Hautier
    Department of Dermatology, CHU Purpan, Toulouse 31024, France
    Br J Dermatol 161:456-63. 2009
    ..Arg396His. These predictions corroborated the analysis of recombinant transglutaminase (TGase)-1 proteins carrying the p.Val359Met and p.Arg396His mutations...
  54. ncbi Transglutaminase activity in the eye: cross-linking in epithelia and connective tissue structures
    M Raghunath
    Department of Dermatology, University of Munster, Germany
    Invest Ophthalmol Vis Sci 40:2780-7. 1999
    To assess the distribution of transglutaminase (TGase) activity in ocular tissues and the target structures for cross-linking.
  55. ncbi Clinical and morphological correlations for transglutaminase 1 gene mutations in autosomal recessive congenital ichthyosis
    E Laiho
    Department of Clinical Chemistry, Institute of Biomedicine, University of Helsinki, Laboratory Department of Helsinki University Central Hospital, Finland
    Eur J Hum Genet 7:625-32. 1999
    ..b>Transglutaminase 1 (TGM1) has been found as a defective gene in a large fraction of patients with lamellar ichthyosis (LI), a ..
  56. doi Lamellar ichthyosis with a novel homozygous C-terminal mutation in the transglutaminase-1 gene
    Laura Rodríguez-Pazos
    Department of Dermatology, Faculty of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain
    Int J Dermatol 48:1195-7. 2009
    The majority of cases of Lamellar ichthyosis (LI) are caused by mutations in the transglutaminase-1 (TGM1) gene...
  57. ncbi Thyroxine stimulates transglutaminase activity in articular chondrocytes
    A K Rosenthal
    Zablocki VA Medical Center and Medical College of Wisconsin, Division of Rheumatology, Department of Medicine, Milwaukee, WI, USA
    Osteoarthritis Cartilage 11:463-70. 2003
    ..Elevated activity levels of the two transglutaminase (Tgase) enzymes (type II Tgase and Factor XIIIA (FXIIIA)) have recently been described as additional features of ..
  58. ncbi Mapping of a second locus for lamellar ichthyosis to chromosome 2q33-35
    L Parmentier
    CNRS URA 1922, Genethon, Evry, France
    Hum Mol Genet 5:555-9. 1996
    ..It was recently demonstrated to result from deleterious mutations in the transglutaminase 1 (TGM1) gene...
  59. doi Fibroblast apoptosis in a patient affected by lamellar ichthyosis
    Daniela Tavian
    Laboratory of Human Molecular Biology and Genetics, Catholic University of the Sacred Heart, Milan, Italy
    J Cutan Pathol 36:417-24. 2009
    ..The pathology may be caused by mutations in transglutaminase 1 (TGM1) gene that encodes an enzyme critical for terminally differentiating keratinocytes...
  60. doi Involvement of transglutaminase in ex vivo maturation of cornified envelopes in the stratum corneum
    T Hirao
    Shiseido Life Science Research Center, Tsuzuki ku, Yokohama 224 8558, Japan
    Int J Cosmet Sci 25:245-57. 2003
    ..Labelled cadaverine as an exogenous substrate for transglutaminase (TGase) could be incorporated into CEs during maturation...
  61. ncbi Lamellar ichthyosis: further narrowing, physical and expression mapping of the chromosome 2 candidate locus
    L Parmentier
    CNRS URA 1922, Genethon, Evry, France
    Eur J Hum Genet 7:77-87. 1999
    ..Keratinocyte transglutaminase (or transglutaminase 1: TGM1) has been demonstrated to be the disease-causing gene in some families, whilst in others, a second ..
  62. pmc Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime
    Silvia García-Cobos
    Antibiotic Laboratory, Bacteriology Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Antimicrob Agents Chemother 51:2564-73. 2007
    ..Some 93.2% of the BLNAR strains had amino acid substitutions at the Lys-Thr-Gly (KTG) motif, the two most common being Asn526 to Lys (83.9%) and Arg517 to His (9.3%)...
  63. ncbi Dependence of Giardia lamblia encystation on novel transglutaminase activity
    B J Davids
    Department of Pathology, Division of Infectious Diseases, UCSD Medical Center, University of California, CTF C 403, 214 Dickinson Street, San Diego, CA 92103 8416, USA
    Mol Biochem Parasitol 136:173-80. 2004
    ..we found that three protein disulfide isomerases (PDI) from Giardia lamblia (gPDI) also have transglutaminase (TGase) activity in vitro...
  64. ncbi Preparation and evaluation of ketorolac tromethamine gel containing genipin for periodontal diseases
    Jeon Heon Yang
    College of Pharmacy, Woosuk University, Wanju 565 701, Korea
    Arch Pharm Res 30:871-5. 2007
    Ketorolac tromethamine gel (KT gel) and ketorolac tromethamine gel containing genipin (KTG gel) were prepared and their therapeutic effects on periodontitis were evaluated...
  65. ncbi Antisense inhibition of transglutaminase 2 affects development of mouse embryo submandibular gland in organ culture
    Suk Keun Lee
    Department of Oral Pathology, College of Dentistry, Kangnung National University, Gangneung 210 702, Republic of Korea
    Arch Oral Biol 50:789-98. 2005
    Tissue transglutaminase (TGase 2) has been implicated in numerous cellular functions, i.e., apoptosis, differentiation, extracellular matrix protein cross-linking and organogenesis...
  66. ncbi Epidermal growth factor and keratinocyte growth factor differentially regulate epidermal migration, growth, and differentiation
    S Gibbs
    Department of Dermatology, Leiden University Medical Centre, The Netherlands
    Wound Repair Regen 8:192-203. 2000
    ..and migration, and an increase in keratin 6, keratin 16, skin-derived antileukoproteinase, involucrin and transglutaminase 1 expression...
  67. doi New mutations in the transglutaminase 1 gene in three families with lamellar ichthyosis
    X Cao
    Department of Dermatology, First Affiliated Hospital of Nan Chang University, Nan Chang, China
    Clin Exp Dermatol 34:904-9. 2009
    ..Gene mutation in transglutaminase 1 (TGM1), which mediates cross-links in the formation of the cell envelope during terminal differentiation of ..
  68. ncbi Increased nuclear beta-catenin in suprabasal involved psoriatic epidermis
    P J Hampton
    Dermatological Sciences, Institute of Cellular Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Br J Dermatol 157:1168-77. 2007
    ..beta-catenin is not required for keratinocyte proliferation but has been shown to regulate keratinocyte stem cells and hair follicle morphogenesis...
  69. doi Transglutaminase-1 mutations in omani families with lamellar ichthyosis
    Aisha Al-Naamani
    Department of Genetics, Sultan Qaboos University, Al Khoud, Oman
    Med Princ Pract 22:438-43. 2013
    ..To determine the molecular basis of familial ichthyosis in three Omani families...
  70. ncbi Screening for the preferred substrate sequence of transglutaminase using a phage-displayed peptide library: identification of peptide substrates for TGASE 2 and Factor XIIIA
    Yoshiaki Sugimura
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464 8601, Japan
    J Biol Chem 281:17699-706. 2006
    Mammalian transglutaminase (TGase) catalyzes covalent cross-linking of peptide-bound lysine residues or incorporation of primary amines to limited glutamine residues in substrate proteins...
  71. ncbi Kinetic analysis of the action of tissue transglutaminase on peptide and protein substrates
    April Case
    Laboratory for Drug Discovery in Neurodegeneration, Harvard Center for Neurodegeneration and Repair, 65 Landsdowne Street, Fourth Floor, Cambridge, Massachusetts 02139, USA
    Biochemistry 42:9466-81. 2003
    Tissue transglutaminase (TGase) catalyzes transfer of gamma-acyl moieties of Gln residues in peptides or protein substrates to either water or amine nucleophiles through an acyl-enzyme intermediate formed from initial acyl-transfer to an ..
  72. ncbi Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration
    Bruce A Citron
    Neurobiology Research Laboratory, Veterans Affairs Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA
    Neurochem Int 40:69-78. 2002
    ..One novel mechanism for this may be transglutaminase (TGase)-mediated protein crosslinking, that is involved in a variety of natural processes ranging from the stabilization ..
  73. ncbi Effects of tissue transglutaminase on beta -amyloid1-42-induced apoptosis
    Joseph J Wakshlag
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Protein J 25:83-94. 2006
    Tissue transglutaminase (TGase) has been implicated in both cell survival and apoptosis. Here we investigate the role of TGase in beta-amyloid-induced neurotoxicity using retinoic acid (RA)-differentiated, neuronal SH-SY5Y cells...
  74. pmc Importance of Ca(2+)-dependent transamidation activity in the protection afforded by tissue transglutaminase against doxorubicin-induced apoptosis
    Sunando Datta
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 45:13163-74. 2006
    Tissue transglutaminase II (TGase-II), which is capable of both GTP binding and transamidation activities, has been implicated in a variety of biological disorders ranging from cancer to neurodegenerative diseases...
  75. doi Improvement of transglutaminase production by extending differentiation phase of Streptomyces hygroscopicus: mechanism and application
    Kangkang Chen
    School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, China
    Appl Microbiol Biotechnol 97:7711-9. 2013
    Streptomyces transglutaminase (TGase) is an important industrial enzyme that catalyzes cross-linking of proteins. It is secreted as a zymogene and then is activated by proteases under physiological conditions...
  76. doi IgE production in CD40/CD40L cross-talk of B and mast cells and mediator release via TGase 2 in mouse allergic asthma
    Gwan Ui Hong
    Department of Pharmacology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
    Cell Signal 25:1514-25. 2013
    b>TGase 2 is over-expressed in a variety of inflammatory diseases including allergic asthma...
  77. pmc Congenital lamellar ichthyosis in Tunisia is caused by a founder nonsense mutation in the TGM1 gene
    Nacim Louhichi
    Human Molecular Genetic Laboratory, Faculty of Medicine of Sfax, Avenue Magida Boulila, 3029, Sfax, Tunisia
    Mol Biol Rep 40:2527-32. 2013
    ..Mutations in the TGM1 gene encoding transglutaminase-1 are a major cause of LI...
  78. ncbi Changes in growth rate and thyroid- and sex-hormones blood levels in rats under sub-chronic lithium treatment
    M S Allagui
    Laboratoire d Ecophysiologie Animale, Faculte des Sciences de Sfax, 3018 Sfax, Tunisie
    Hum Exp Toxicol 25:243-50. 2006
    ..batches and fed commercial pellets: one batch was the control and the second and third batches were given 2 g (Li1) and 4 g (Li2) of lithium carbonate/kg of food/day, respectively...
  79. ncbi Therapeutic effects of cystamine in a murine model of Huntington's disease
    Alpaslan Dedeoglu
    Geriatric Research Education and Clinical Center, Bedford Veterans Affairs Medical Center, Bedford, Massachusetts 01730, USA
    J Neurosci 22:8942-50. 2002
    ..protein can contribute to toxic cellular aggregates that may be formed in part by tissue transglutaminase (Tgase). Tgase activity is increased in HD brain...
  80. doi Discovery and identification of a novel Ligon lintless-like mutant (Lix) similar to the Ligon lintless (Li1) in allotetraploid cotton
    Caiping Cai
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, People s Republic of China
    Theor Appl Genet 126:963-70. 2013
    ..The Lix mutant is similar in morphology to the Ligon lintless (Li1) mutant. Genetic analysis and molecular mapping were performed for the Lix and Li1 mutants...
  81. ncbi Specific TGM1 mutation profiles in bathing suit and self-improving collodion ichthyoses: phenotypic and genotypic data from 9 patients with dynamic phenotypes of autosomal recessive congenital ichthyosis
    Emmanuelle Bourrat
    Department of Dermatology, Hopital Saint Louis, Paris, France
    Arch Dermatol 148:1191-5. 2012
    ..Bathing suit ichthyosis is characterized by scaling of the skin in a bathing suit pattern, mainly limited to the trunk, whereas SICI is characterized by complete disappearance of the skin lesions...
  82. doi Epigenetic anomalies in childhood growth disorders
    Irene Netchine
    Laboratoire d Explorations Fonctionnelles Endocriniennes, APHP, Hopital Armand Trousseau, INSERM UMRS 938 team 4, Universite Pierre et Marie Curie Paris 6, Paris, France
    Nestle Nutr Inst Workshop Ser 71:65-73. 2013
    ..domains regulated by their own differentially methylated imprinted control region (ICR1 at the H19/IGF2 domain, and ICR2 at the KCNQ1/CDKN1C domain)...
  83. doi Susceptibility of the individual caseins in reconstituted skim milk to cross-linking by transglutaminase: influence of temperature, pH and mineral equilibria
    Katharina Hinz
    School of Food and Nutritional Sciences, University College Cork, Cork, Ireland
    J Dairy Res 79:414-21. 2012
    The susceptibility of total casein and the individual caseins in reconstituted skim milk to transglutaminase (TGase)-induced cross-linking was studied as a function of incubation temperature (5-40 °C), pH (5·0-7·0) and mineral ..
  84. pmc Enzymatic analysis of α-ketoglutaramate--a biomarker for hyperammonemia
    Lenka Halámková
    Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA
    Talanta 100:7-11. 2012
    ..In both procedures, KGM is first converted to α-ketoglutarate (KTG) via a reaction catalyzed by ω-amidase (AMD)...
  85. ncbi Transglutaminase-catalyzed formation of Alzheimer-like insoluble complexes from recombinant tau
    B J Balin
    Division of Neuroscience, Departments of Pathology and Microbiology Immunology, Philadelphia College of Osteopathic Medicine, Evans Hall, Philadelphia, PA
    Methods Mol Med 32:395-404. 2000
    ..modification such as phosphorylation (4,5), glycation (6-9), and crosslinking by transglutaminase (TGase) (10-16)...
  86. ncbi 6/7Li NMR study of the Li1-zNi1+zO2 phases
    Cédric Chazel
    Institut de Chimie de la Matière Condensée de Bordeaux CNRS and ENSCPB, Universite Bordeaux I, 87 Avenue Schweitzer, 33608 Pessac Cedex, France
    Magn Reson Chem 43:849-57. 2005
    A series of Li1-zNi1+zO2 materials have been synthesised by the coprecipitation route...
  87. doi Polyamines and transglutaminase activity are involved in compatible and self-incompatible pollination of Citrus grandis
    Alessandra Gentile
    Dipartimento di Scienze delle Produzioni Agrarie e Alimentari, Universita di Catania, Via Valdisavoia 5, 95123, Catania, Italy
    Amino Acids 42:1025-35. 2012
    ..The polyamine (PA) content as free, perchloric acid (PCA)-soluble and -insoluble fractions and transglutaminase (TGase) activity have been analyzed in order to deepen their possible involvement in the progamic phase of plant ..
  88. doi Enhancement of transglutaminase production in Streptomyces mobaraensis as achieved by treatment with excessive MgCl2
    Lili Zhang
    School of Food Science and Engineering, Harbin Institute of Technology, Harbin, China
    Appl Microbiol Biotechnol 93:2335-43. 2012
    ..the capacity for eight different salts as stress-mediated bioprocesses in the production of transglutaminase (TGase)...
  89. doi Selection of bovine catalase aptamers using non-SELEX
    Jon Ashley
    Department of Chemistry, National University of Singapore, Singapore
    Electrophoresis 33:2783-9. 2012
    ..for the target and aptamer library by optimizing the buffer conditions using 3 × Tris-glycine-potassium phosphate (TGK) buffer as the run buffer and 1× TGK as the selection buffer to give the biggest complex peak...
  90. ncbi A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines
    Pascal D Fortin
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 448:824-7. 2007
    ..Here we report that AdmF, a transglutaminase (TGase) homologue, catalyses the formation of the first amide bond, an N-acyl-beta-peptide link, in andrimid biosynthesis...
  91. doi Secular trends and dynamics of hospital associated methicillin-resistant Staphylococcus aureus
    L Armand-Lefevre
    Bichat Claude Bernard University Hospital, Assistance Publique Hopitaux de Paris, EA 3964, Paris, France
    Clin Microbiol Infect 16:1435-41. 2010
    ..Four patterns (P) were found: P1 (KTGFq R, n = 776), P2 [KTFq R; G susceptible (S), n = 1630], P3 (Fq R; KTG S, n = 397) and P4 (Fq S; any KTG susceptibility, n = 201)...
  92. doi Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles
    Asaka Yamane
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    FEBS J 277:3564-74. 2010
    ..Two main transglutaminases isoforms, epidermal-type (TGase 3) and keratinocyte-type (TGase 1), are cooperatively involved in this process of differentiating keratinocytes...
  93. doi Transglutaminase II interacts with rac1, regulates production of reactive oxygen species, expression of snail, secretion of Th2 cytokines and mediates in vitro and in vivo allergic inflammation
    Youngmi Kim
    School of Biological Sciences, College of Natural Sciences, Kangwon National University, Chunchon, Republic of Korea
    Mol Immunol 47:1010-22. 2010
    Transglutaminase II (TGase II) is a protein cross-linking enzyme with diverse biological functions. Here we report the role of TGase II in allergic inflammation...
  94. ncbi A cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites
    Yasuyuki Matsuda
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Biol Chem 282:33545-52. 2007
    ..We have previously reported that horseshoe crab transglutaminase (TGase) promotes cross-linking of a clotting protein (coagulin) with hemocyte-derived proteins (proxins), resulting in ..
  95. doi Leifsonia psychrotolerans sp. nov., a psychrotolerant species of the family Microbacteriaceae from Livingston Island, Antarctica
    Lars Ganzert
    Alfred Wegener Institute for Polar and Marine Research, Research Department Potsdam, Telegrafenberg A45, 14473 Potsdam, Germany
    Int J Syst Evol Microbiol 61:1938-43. 2011
    A cold-tolerant, yellow-pigmented, Gram-positive, motile, facultatively anaerobic bacterial strain, LI1(T), was isolated from a moss-covered soil from Livingston Island, Antarctica, near the Bulgarian station St. Kliment Ohridski...
  96. doi TG2 protects neuroblastoma cells against DNA-damage-induced stress, suppresses p53 activation
    Janusz Tucholski
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720, 7th Ave South, SC 981, Birmingham, AL 35294 0017, USA
    Amino Acids 39:523-32. 2010
    Tissue transglutaminase (TG2) is a multifunctional member of the transglutaminase (TGase) family (E.C.2.3.2...
  97. ncbi Transglutaminase 1 stabilizes beta-actin in endothelial cells correlating with a stabilization of intercellular junctions
    Werner Baumgartner
    Department of Cellular Neurobionics, Institute of Biology II, RWTH Aachen, Aachen, and Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    J Vasc Res 44:234-40. 2007
    ..mouse myocardium become resistant to various barrier-compromising stimuli correlating with the expression of transglutaminase 1 (TGase1) and its translocation towards cellular junctions...
  98. doi Effects of Hydroxydecine(®) (10-hydroxy-2-decenoic acid) on skin barrier structure and function in vitro and clinical efficacy in the treatment of UV-induced xerosis
    Hélène Duplan
    Centre R and D Pierre Fabre 3, avenue Hubert Curien, 31035 Toulouse, France
    Eur J Dermatol 21:906-15. 2011
    ..Hydroxydecine(®) thus proved its efficacy in activating keratinocyte differentiation processes in vitro, restoring skin barrier function and reducing inflammation ex vivo, and hydrating dry skin in vivo...
  99. ncbi Formation of fibrous materials from dense calcium caseinate dispersions
    Julita M Manski
    Food and Bioprocess Engineering Group, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    Biomacromolecules 8:1271-9. 2007
    Application of shear and cross-linking enzyme transglutaminase (Tgase) induced fibrous hierarchical structures in dense (30% w/w) calcium caseinate (Ca-caseinate) dispersions...
  100. doi Bathing suit ichthyosis
    Felicidade Trindade
    Department of Dermatology, Hospital de Cascais, Av Brigadeiro Victor Novais Gonçalves, 2755 009 Cascais, Portugal
    Eur J Dermatol 20:447-50. 2010
    ..suit ichthyosis (BSI) is a rare variant of autosomal recessive lamellar ichthyosis due to transglutaminase-1 (TGase-1) gene mutations leading to a temperature sensitive phenotype...

Research Grants73

  1. RETINOIC ACID-ACTIVATED GTP-BINDING/TRANSGLUTAMINASE
    RICHARD CERIONE; Fiscal Year: 2003
    ..Recently, we identified two candidate target/binding partners for the TGase, namely, the eukaryotic initiation factor (eIF)5A, and the retinoblastoma gene product (Rb), both of which are ..
  2. Molecular Targets in Peptidoglycan Synthesis
    Christopher Davies; Fiscal Year: 2010
    ..gonorrhoeae with intermediate-level resistance to ceftriaxone. The role of the lytic TGase MltA as part of a multienzyme complex involved in cell division will be investigated by genetic studies...
  3. Molecular Targets in Peptidoglycan Synthesis
    Christopher Davies; Fiscal Year: 2009
    ..gonorrhoeae with intermediate-level resistance to ceftriaxone. The role of the lytic TGase MltA as part of a multienzyme complex involved in cell division will be investigated by genetic studies...
  4. TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTS
    Ann Rosenthal; Fiscal Year: 2002
    ..The enzyme transglutaminase (TGase) catalyzes a unique post-translational modification of proteins, resulting in diverse biological effects in ..
  5. Caspase-14 and the Treatment of Psoriasis
    Hasan Mukhtar; Fiscal Year: 2010
    ....
  6. G PROTEIN AND PHOSPHOLIPASE C IN HORMONE SIGNALING
    Mie Jae Im; Fiscal Year: 2001
    ..Our recent studies revealed that Galphah is a multifunctional enzyme Known as tissue type transglutaminase (TGase II). Thus, Galphah possesses two important biological functions the GTPase and transglutaminase activities...
  7. TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTS
    Ann Rosenthal; Fiscal Year: 2007
    ..We identified the transglutaminase (Tgase) family of enzymes as important participants in CPPD crystal formation...
  8. KERATINOCYTE TRANSGLUTAMINASE--STRUCTURE AND REGULATION
    Robert Rice; Fiscal Year: 1993
    Keratinocyte transglutaminase (TGK) is a membrane-bound phosphoprotein responsible for cross-linked envelope formation during terminal differentiation in epidermal cells...
  9. Role of GTP-binding/transglutaminase in cell survival
    RICHARD CERIONE; Fiscal Year: 2007
    Tissue transglutaminase (TGase) is an approximately 80 kDa protein that exhibits GTP-binding and hydrolytic activities like signaling G proteins, as well as an enzymatic (transamidation) activity that catalyzes covalent linkages between ..
  10. Transglutaminase 2 S-Nitrosylation: Role in Age-Related Vascular Stiffness
    Dan E Berkowitz; Fiscal Year: 2010
    ..Furthermore, using TG2-/- mice, we show that TG2 is the primary TGase mediating stiffness of conduit arteries, and that it is regulated by endothelium-derived NO...
  11. Research Education for Future Physician-Scientists in Child Psychiatry
    James Leckman; Fiscal Year: 2007
    ..This fellowship program was initially funded by the Klingenstein Third Generation (KTG) Foundation in 2001...
  12. PROBES FOR CYTOMETRY
    Zbigniew Darzynkiewicz; Fiscal Year: 2009
    ..3) Activation of transglutaminase (TGase 2) during apoptosis...
  13. MITOCHONDRIAL DYSFUNCTION IN NEUROGEGENERATION OF AGING
    Gary Gibson; Fiscal Year: 2007
    ..that form the key mitochondrial enzyme a-ketoglutarate dehydrogenase complex (KGDHC) and transglutaminase (TGase). Brain KGDHC activity declines in AD and HD. The reduction correlates highly with clinical state, at least in AD...
  14. MECHANISM OF TRANSGLUTAMINASE TYPE I REGULATION BY HOXA7
    PETER LA CELLE; Fiscal Year: 2003
    ..and cis-acting elements that regulate differentiation-specific epidermal genes, such as transglutaminase type 1 (TGM1)...
  15. Molecular Mechanism of Matrix GLA Protein (MGP)
    KRISTINA I BOSTROM; Fiscal Year: 2010
    ..We will characterize activation of SMAD signaling and relevant reporter genes induced by TGF-li1, BMP-2 and BMP-4 in presence of MGP, and identify the TGF-li / BMP receptors that are regulated by MGP...
  16. Role of GTP-binding/transglutaminase in cell survival and migration
    Richard A Cerione; Fiscal Year: 2010
    Tissue transglutaminase-2 (TGase-2) has been suggested to be involved in a number of vitally important biological responses ranging from neuronal differentiation and neurodegenerative diseases to the regulation of cell growth and ..