TGFBI

Summary

Gene Symbol: TGFBI
Description: transforming growth factor, beta-induced, 68kDa
Alias: BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1, RGD-CAP, RGD-containing collagen-associated protein, beta ig-h3, kerato-epithelin, transforming growth factor-beta-induced protein ig-h3
Species: human

Top Publications

  1. ncbi Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro
    R G LeBaron
    Division of Life Sciences, University of Texas at San Antonio, USA
    J Invest Dermatol 104:844-9. 1995
  2. ncbi [Arterial dysfunction after treatment of coarctation of the aorta]
    Y Aggoun
    , 149, , 75743 Paris
    Arch Mal Coeur Vaiss 94:785-9. 2001
  3. ncbi BIGH3 gene mutations and rapid detection in Korean patients with corneal dystrophy
    H S Kim
    Laboratory of Ophthalmology and Visual Science, Catholic Research Institutes of Medical Science, Catholic University Medical College, Seoul, Korea
    Cornea 20:844-9. 2001
  4. pmc An atypical phenotype of Reis-Bücklers corneal dystrophy caused by the G623D mutation in TGFBI
    Dandan Li
    Department of Ophthalmology, Harbin Medical University The 2nd Affiliated Hospital, Harbin, China
    Mol Vis 14:1298-302. 2008
  5. doi A corneal dystrophy associated with transforming growth factor beta-induced Gly623Asp mutation an amyloidogenic phenotype
    Claudia Auw-Haedrich
    University Eye Hospital, Freiburg, Germany
    Ophthalmology 116:46-51. 2009
  6. pmc Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation
    Chaoyu Ma
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 22:308-21. 2008
  7. pmc The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel
    Ahmed Ashour Ahmed
    Functional Genomics of Drug Resistance Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Cancer Cell 12:514-27. 2007
  8. ncbi RGD peptides released from beta ig-h3, a TGF-beta-induced cell-adhesive molecule, mediate apoptosis
    Jung Eun Kim
    Department of Biochemistry, Kyungpook National University School of Medicine, Taegu, Korea
    Oncogene 22:2045-53. 2003
  9. pmc Human U87 astrocytoma cell invasion induced by interaction of βig-h3 with integrin α5β1 involves calpain-2
    Jie Ma
    Department of Neurosurgery, Tangdu Hospital, Forth Military Medical University, Xi an, China
    PLoS ONE 7:e37297. 2012
  10. pmc Genotype-phenotype correlations of TGFBI p.Leu509Pro, p.Leu509Arg, p.Val613Gly, and the allelic association of p.Met502Val-p.Arg555Gln mutations
    Florence Niel-Butschi
    INSERM, U1016, Institut Cochin, CNRS, UMR 8104, Universite Paris Descartes, Paris, France
    Mol Vis 17:1192-202. 2011

Research Grants

  1. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    Jerome Engel; Fiscal Year: 2002
  2. QUANTITATIVE ANALYSIS OF LEFT VENTRICULOPLASTY--CHF
    Mark Ratcliffe; Fiscal Year: 2009
  3. BIGH3 Wild-Type and Mutant Proteins
    GORDON KENNETH KLINTWORTH; Fiscal Year: 2010
  4. BIGH3 Wild-Type and Mutant Proteins
    Gordon Klintworth; Fiscal Year: 2009
  5. NHE3 Polymorphisms and Chronic Diarrheal Diseases
    Xinjun Zhu; Fiscal Year: 2013
  6. NHE3 Polymorphisms and Chronic Diarrheal Diseases
    Xinjun Zhu; Fiscal Year: 2013
  7. MOLECULAR CHARACTERIZATION OF ROCHALIMAEA ANTIGENS
    Burt Anderson; Fiscal Year: 1999
  8. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2010
  9. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew Huang; Fiscal Year: 2009
  10. FUNCTIONAL PROPERTIES OF HUMAN P68 (BIG H3) PROTEIN IN CORNEA
    RICHARD LEBARON; Fiscal Year: 1999

Detail Information

Publications235 found, 100 shown here

  1. ncbi Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro
    R G LeBaron
    Division of Life Sciences, University of Texas at San Antonio, USA
    J Invest Dermatol 104:844-9. 1995
    ..Finally, we show that recombinant beta IG-H3 supported attachment and spreading of dermal fibroblasts, suggesting that beta IG-H3 may function as an extracellular attachment protein in skin...
  2. ncbi [Arterial dysfunction after treatment of coarctation of the aorta]
    Y Aggoun
    , 149, , 75743 Paris
    Arch Mal Coeur Vaiss 94:785-9. 2001
    ..of the common carotid artery (CCA) to define mechanical indexes: Cross sectional compliance (CSC), distensibility (CSD) and incremental elastic modulus (Einc) in each group...
  3. ncbi BIGH3 gene mutations and rapid detection in Korean patients with corneal dystrophy
    H S Kim
    Laboratory of Ophthalmology and Visual Science, Catholic Research Institutes of Medical Science, Catholic University Medical College, Seoul, Korea
    Cornea 20:844-9. 2001
    Mutations in the BIGH3 gene on chromosome 5q31 cause four distinct autosomal dominant corneal dystrophies. We sought to determine whether the BIGH3 gene mutation was responsible for corneal dystrophy in Korean patients.
  4. pmc An atypical phenotype of Reis-Bücklers corneal dystrophy caused by the G623D mutation in TGFBI
    Dandan Li
    Department of Ophthalmology, Harbin Medical University The 2nd Affiliated Hospital, Harbin, China
    Mol Vis 14:1298-302. 2008
    To characterize the molecular defects in the TGFBI gene in a Chinese family with an unusual phenotype of Reis-Bücklers corneal dystrophy (RBCD).
  5. doi A corneal dystrophy associated with transforming growth factor beta-induced Gly623Asp mutation an amyloidogenic phenotype
    Claudia Auw-Haedrich
    University Eye Hospital, Freiburg, Germany
    Ophthalmology 116:46-51. 2009
    To present the light and electron microscopic findings of a unique corneal dystrophy never before described in a German family carrying the Gly623Asp Mutation of the TGFBI gene with late clinical onset.
  6. pmc Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation
    Chaoyu Ma
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 22:308-21. 2008
    ..Here we report that elevated expression of betaig-h3/TGFBI (transforming growth factor, beta-induced), an extracellular matrix protein secreted by colon cancer cells, is ..
  7. pmc The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel
    Ahmed Ashour Ahmed
    Functional Genomics of Drug Resistance Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Cancer Cell 12:514-27. 2007
    ..Here, we show that loss of the ECM protein TGFBI (transforming growth factor beta induced) is sufficient to induce specific resistance to paclitaxel and mitotic ..
  8. ncbi RGD peptides released from beta ig-h3, a TGF-beta-induced cell-adhesive molecule, mediate apoptosis
    Jung Eun Kim
    Department of Biochemistry, Kyungpook National University School of Medicine, Taegu, Korea
    Oncogene 22:2045-53. 2003
    ..The anti-beta ig-h3 antibody blocks TGF-beta-induced apoptosis. Thus, beta ig-h3 may be important in regulating cell apoptosis by providing soluble RGD peptides...
  9. pmc Human U87 astrocytoma cell invasion induced by interaction of βig-h3 with integrin α5β1 involves calpain-2
    Jie Ma
    Department of Neurosurgery, Tangdu Hospital, Forth Military Medical University, Xi an, China
    PLoS ONE 7:e37297. 2012
    ..Our data showed that βig-h3 co-localized with integrin α5β1 to enhance the invasion of U87 cells, and that calpain-2, is involved in this process, acting as a downstream molecule...
  10. pmc Genotype-phenotype correlations of TGFBI p.Leu509Pro, p.Leu509Arg, p.Val613Gly, and the allelic association of p.Met502Val-p.Arg555Gln mutations
    Florence Niel-Butschi
    INSERM, U1016, Institut Cochin, CNRS, UMR 8104, Universite Paris Descartes, Paris, France
    Mol Vis 17:1192-202. 2011
    Investigate the genotype-phenotype correlations for five TGFBI (transforming growth factor, beta-induced) mutations including one novel pathogenic variant and one complex allele affecting the fourth FAS1 domain of keratoepithelin, and ..
  11. ncbi Transforming growth factor-beta-inducible gene-h3 (beta(ig)-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of alpha6beta4 integrin
    Mi Ok Kim
    Graduate School of East West Medical Science, Kyung Hee University, 1 Seochun, Yong In 449 701, South Korea
    Neurosci Lett 336:93-6. 2003
    ....
  12. ncbi TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients
    S V V Kalyana Chakravarthi
    Kallam Anji Reddy Molecular Genetics Laboratory, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 46:121-5. 2005
    To identify mutations in the TGFBI gene in Indian patients with lattice corneal dystrophy (LCD) or granular corneal dystrophy (GCD) and to look for genotype-phenotype correlations.
  13. pmc Analysis of TGFBI gene mutations in Chinese patients with corneal dystrophies and review of the literature
    Juhua Yang
    Biomedical Engineering Center, Fujian Medical University, Fuzhou, Fujian, China
    Mol Vis 16:1186-93. 2010
    To analyze human transforming growth factor b-induced (TGFBI) gene mutations in Chinese patients with corneal dystrophies (CDs).
  14. doi βig-h3 regulates store-operated Ca2+ entry and promotes the invasion of human hepatocellular carcinoma cells
    Yun shan Guo
    Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, State Key Discipline of Cell Biology, Fourth Military Medical University, Xian 710032, Peoples Republic of China
    Cell Biol Int 35:811-7. 2011
    ..Our findings suggest that the expression of βig-h3 might play an important role in the regulation of store-operated Ca2+ entry to increase the invasive potential of HCC cells...
  15. pmc Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene
    Henrik Karring
    Institute of Chemical Engineering, Biotechnology and Environmental Technology, Faculty of Engineering, University of Southern Denmark, Niels Bohrs Alle 1, DK 5230 Odense M, Denmark
    Exp Eye Res 96:163-70. 2012
    ..lattice corneal dystrophy (LCD) are associated with mutations in the transforming growth factor beta induced gene (TGFBI)...
  16. ncbi Clinical findings and treatments of granular corneal dystrophy type 2 (avellino corneal dystrophy): a review of the literature
    Kyung Eun Han
    Department of Ophthalmology, Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seodaemun Ku, Seoul, Korea
    Eye Contact Lens 36:296-9. 2010
    ..To review the literature about clinical findings and treatments of granular corneal dystrophy type 2 (GCD2)...
  17. ncbi Identification of motifs in the fasciclin domains of the transforming growth factor-beta-induced matrix protein betaig-h3 that interact with the alphavbeta5 integrin
    Jung Eun Kim
    Cell and Matrix Biology National Research Laboratory, Department of Biochemistry, Kyungpook National University School of Medicine, Taegu 700 422, Korea
    J Biol Chem 277:46159-65. 2002
    ..This suggests that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins...
  18. pmc Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp
    Kasper Runager
    Center for Insoluble Protein Structures, Department of Molecular Biology, Aarhus University, 8000 Aarhus, Denmark
    J Biol Chem 286:4951-8. 2011
    Mutations in the human TGFBI gene encoding TGFBIp have been linked to protein deposits in the cornea leading to visual impairment. The protein consists of an N-terminal Cys-rich EMI domain and four consecutive fasciclin 1 (FAS1) domains...
  19. doi SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutation
    R V Basaiawmoit
    Center for Insoluble Protein Structures inSPIN, iNANO Interdisciplinary Nanoscience Center, Department of Molecular Biology, Aarhus University, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Mol Biol 408:503-13. 2011
    ..The protein is of interest because mutations in the TGFBI gene encoding TGFBIp lead to corneal dystrophy (CD), a condition where protein aggregates within the cornea ..
  20. ncbi Frequent promoter hypermethylation of TGFBI in epithelial ovarian cancer
    Sokbom Kang
    Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    Gynecol Oncol 118:58-63. 2010
    ..Using pharmacologic unmasking and genome-wide differential methylation analysis, we identified a novel methylated gene in ovarian cancers...
  21. ncbi Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of avellino corneal dystrophy
    Sean L Edelstein
    Saint Louis University Eye Institute, Saint Louis University School of Medicine, Saint Louis, MO, USA
    Cornea 29:698-700. 2010
    ..To present a patient with a genotype usually associated with lattice corneal dystrophy but with clinical and histopathologic features of advanced Avellino corneal dystrophy...
  22. ncbi Downregulation of Betaig-h3 gene is causally linked to tumorigenic phenotype in asbestos treated immortalized human bronchial epithelial cells
    Yong L Zhao
    Center for Radiological Research, College of Physicians and Surgeons, Joseph Mailman School of Public Health, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Oncogene 21:7471-7. 2002
    ..The result strongly suggests that loss of Betaig-h3 expression is a frequent event in human cancer and causally related to acquisition of tumorigenic phenotype in asbestos-treated BEP2D cells...
  23. ncbi Covalent and non-covalent interactions of betaig-h3 with collagen VI. Beta ig-h3 is covalently attached to the amino-terminal region of collagen VI in tissue microfibrils
    Eric Hanssen
    Department of Pathology, University of Adelaide, South Australia, 5005, Australia
    J Biol Chem 278:24334-41. 2003
    ..Overall the study supports the concept that betaig-h3 is extensively associated with collagen VI in some tissues and that it plays an important modulating role in collagen VI microfibril function...
  24. ncbi Elevation of urinary betaig-h3, transforming growth factor-beta-induced protein in patients with type 2 diabetes and nephropathy
    Sung Woo Ha
    Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700 422, Republic of Korea
    Diabetes Res Clin Pract 65:167-73. 2004
    ..These data show that urinary levels of betaig-h3 are elevated in type 2 diabetic patients with nephropathy and may be used as a marker of diabetic nephropathy...
  25. doi Clinical and genetic features of TGFBI-linked corneal dystrophies in Mexican population: description of novel mutations and novel genotype-phenotype correlations
    Juan Carlos Zenteno
    Department of Biochemistry, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
    Exp Eye Res 89:172-7. 2009
    ..Most CDs are inherited in an autosomal dominant fashion and mutations in the TGFBI gene at chromosome 5q31 cause the majority of CDs affecting the stromal layer...
  26. doi TGFBI mutational analysis in a New Zealand population of inherited corneal dystrophy patients
    Andrea L Vincent
    Department of Ophthalmology, Faculty of Medical and Health Sciences, National Eye Centre, University of Auckland, Auckland, New Zealand
    Br J Ophthalmol 94:836-42. 2010
    ..Mutations in the transforming growth factor beta-induced (TGFBI) gene segregate with a wide range of phenotypically heterogeneous corneal dystrophies...
  27. pmc Genotype-phenotype correlation of TGFBI corneal dystrophies in Polish patients
    Anna K Nowińska
    Department of Ophthalmology, District Railway Hospital, Katowice, Poland
    Mol Vis 17:2333-42. 2011
    To analyze genotype-phenotype correlation in patients originating from Polish population with the transforming growth factor beta induced (TGFBI) corneal dystrophies.
  28. pmc Extremely varied phenotypes in granular corneal dystrophy type 2 heterozygotes
    Kyung Eun Han
    Corneal Dystrophy Research Institute, Yonsei University College of Medicine, 50 Yonseiro, Seodaemun gu, Seoul, Korea
    Mol Vis 18:1755-62. 2012
    To investigate the phenotypic variability of patients bearing the heterozygous R124H mutation in the TGFBI (transforming growth factor-beta-induced) gene that causes granular corneal dystrophy type 2 (GCD2).
  29. ncbi Clinical and genetic profile of Avellino corneal dystrophy in 2 families from north India
    Preeti Paliwal
    Laboratory of Cyto Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi
    Arch Ophthalmol 127:1373-6. 2009
    ..To report Avellino corneal dystrophy and underlying R124H mutation in 2 families of Indian origin...
  30. doi TL1A induces the expression of TGF-β-inducible gene h3 (βig-h3) through PKC, PI3K, and ERK in THP-1 cells
    Seung Hee Lee
    Kyungpook National University, Daegu, Republic of Korea
    Cell Immunol 266:61-6. 2010
    ....
  31. ncbi Loss of Betaig-h3 protein is frequent in primary lung carcinoma and related to tumorigenic phenotype in lung cancer cells
    Yongliang Zhao
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mol Carcinog 45:84-92. 2006
    ..These observations demonstrate that downregulation of Betaig-h3 gene is a frequent event and related to the tumor progression in human lung cancer...
  32. ncbi cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta
    J Skonier
    Bristol Myers Squibb, Seattle, WA 98121
    DNA Cell Biol 11:511-22. 1992
    ..Since beta ig-h3 is induced in several cell lines whose proliferation is affected by TGF-beta 1, it may be involved in mediating some of the signals of this multifunctional growth modulator...
  33. pmc Reduced penetrance in familial Avellino corneal dystrophy associated with TGFBI mutations
    Wenping Cao
    Eye Hospital, The First Affiliated Hospital, Harbin Medical University, Harbin, China
    Mol Vis 15:70-5. 2009
    ..To characterize the clinical phenotype, histopathological features, and molecular genetic basis of an Avellino corneal dystrophy (ACD) in a Chinese family...
  34. pmc TGFBI mutation screening and genotype-phenotype correlation in north Indian patients with corneal dystrophies
    Preeti Paliwal
    Laboratory of Cyto Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
    Mol Vis 16:1429-38. 2010
    ..of corneal dystrophy patients from North India for mutations in the transforming growth factor beta induced (TGFBI) gene, to correlate genotypes to phenotypes, to describe structural implications of various mutations on protein ..
  35. pmc An R124C mutation in TGFBI caused lattice corneal dystrophy type I with a variable phenotype in three Chinese families
    Zhe Liu
    Department of Ophthalmology, Medical College of Zhejiang University, Hangzhou, China
    Mol Vis 14:1234-9. 2008
    ..A genetic and clinical study of three unrelated Chinese pedigrees with a variable phenotype of lattice corneal dystrophy type I (LCD I)...
  36. ncbi Allelic homogeneity due to a founder mutation in Japanese patients with lattice corneal dystrophy type IIIA
    Kaoru Tsujikawa
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Med Genet 113:20-2. 2002
    Lattice corneal dystrophies (LCDs) are caused by mutations of the transforming growth factor beta-induced gene (TGFBI, formerly betaig-h3). LCD type IIIA (LCDIIIA) has been reported mostly from Japan...
  37. doi TGFBI gene mutation in a Chinese pedigree with Reis-Bücklers corneal dystrophy
    Qingfeng Liang
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Ophthalmic Physiol Opt 32:74-80. 2012
    To characterize the molecular defects in the TGFBI gene in a Chinese family with Reis-Bücklers corneal dystrophy (RBCD), and to study the relationship between the gene mutations and the clinical manifestations.
  38. pmc Granular and lattice deposits in corneal dystrophy caused by R124C mutation of TGFBIp
    Dhara A Patel
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cornea 29:1215-22. 2010
    ..We investigated the presence of these deposits in other TGFBI mutations and the use of Thioflavin-T (ThT), a fluorescent amyloid stain for characterizing corneal amyloid ..
  39. ncbi Genotype-phenotype correlation in 2 Indian families with severe granular corneal dystrophy
    Chitra Kannabiran
    Kallam Anji Reddy Molecular Genetics Laboratory and Ophthalmic Pathology Service, Professor Brien Holden Eye Research Centre, L V Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad 500 034, India
    Arch Ophthalmol 123:1127-33. 2005
    ..To determine genotypes in 2 Indian families with severe granular corneal dystrophy, to document clinical and histopathologic features, and to attempt a genotype-phenotype correlation...
  40. ncbi TGFBI (BIGH3) gene mutations in German families: two novel mutations associated with unique clinical and histopathological findings
    C Gruenauer-Kloevekorn
    Department of Ophthalmology, Martin Luther University, Ernst Grube Strasse 40, 06097 Halle, Germany
    Br J Ophthalmol 93:932-7. 2009
    To report the clinical, histopathological and immunohistochemical findings of two novel mutations within the TGFBI gene.
  41. doi Arg124Cys mutation of the TGFBI gene in 2 Chinese families with Thiel-Behnke corneal dystrophy
    Liu Chang
    Beijing Tongren Ophthalmic Center, Beijing Institute of Ophthalmology, Capital University of Medical Sciences, Beijing, China
    Arch Ophthalmol 127:641-4. 2009
    To analyze transforming growth factor beta-induced (TGFBI) gene mutations in 2 Chinese families with Thiel-Behnke corneal dystrophy (TBCD).
  42. ncbi A new L527R mutation of the betaIGH3 gene in patients with lattice corneal dystrophy with deep stromal opacities
    K Fujiki
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Hum Genet 103:286-9. 1998
    ..We conclude that there are now at least six different mutations that have been detected in the betaIGH3 gene on chromosome 5q31 and that lead to corneal dystrophy...
  43. ncbi The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin
    Paul C Billings
    Department of Orthopedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28003-9. 2002
    ..Our results identify FN and Col I as two ligands of (beta)ig-h3 in the ECM...
  44. ncbi TGFBI gene mutations in Brazilian patients with corneal dystrophy
    H P Solari
    Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Eye (Lond) 21:587-90. 2007
    To investigate the transforming growth factor beta-induced gene (TGFBI) mutations in Brazilian patients with corneal dystrophy and to evaluate the phenotype-genotype correlation in these patients.
  45. pmc Novel and known mutations of TGFBI, their genotype-phenotype correlation and structural modeling in 3 Chinese families with lattice corneal dystrophy
    Xingwu Zhong
    Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, P R China
    Mol Vis 16:224-30. 2010
    To report novel transforming growth factor beta-induced (TGFBI) mutations responsible for lattice corneal dystrophy (LCD), the associated genotype-phenotype correlation, and structural changes in the mutant proteins in three Chinese ..
  46. ncbi Identification of the alphavbeta3 integrin-interacting motif of betaig-h3 and its anti-angiogenic effect
    Ju Ock Nam
    Cell and Matrix Biology National Research Laboratory, Department of Biochemistry, Kyungpook National University School of Medicine, Taegu 700 422, Korea
    J Biol Chem 278:25902-9. 2003
    ..Our results reveal that betaig-h3 bears alphavbeta3 integrin-interacting motifs that mediate endothelial cell adhesion and migration and, therefore, may regulate angiogenesis...
  47. ncbi Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose
    Suk Hee Lee
    Cell and Matrix Biology, National Research Laboratory, Kyungpook National University, Taegu, Korea
    Kidney Int 64:1012-21. 2003
    ..TGF-beta is believed to be involved in the development of diabetic nephropathy and thus we have assessed the possibility that betaig-h3 may be a downstream molecule in this pathogenic process...
  48. pmc Mutation hot spots in 5q31-linked corneal dystrophies
    E Korvatska
    Unit of Molecular Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Am J Hum Genet 62:320-4. 1998
    Mutations in the BIGH3 gene on chromosome 5q31 cause four distinct autosomal dominant diseases of the human cornea: granular (Groenouw type I), Reis-Bücklers, lattice type I, and Avellino corneal dystrophies...
  49. ncbi A novel mutation of the TGFBI gene found in a Vietnamese family with atypical granular corneal dystrophy
    Nguyen Thanh Ha
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 47:246-8. 2003
    Mutation of the human transforming growth factor beta-induced (TGFBI) gene causes granular corneal dystrophy (GCD) in various ethnic groups...
  50. ncbi A novel nonsense mutation with a compound heterozygous mutation in TGFBI gene in lattice corneal dystrophy type I
    Tohru Sakimoto
    Department of Ophthalmology, Nihon University, School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 47:13-7. 2003
    We examined transforming growth factor beta-induced (TGFBI) gene mutations in a family with lattice corneal dystrophy type I.
  51. pmc A novel mutation I522N within the TGFBI gene caused lattice corneal dystrophy I
    Chunmei Zhang
    Department of Ophthalmology, Harbin Medical University The 2nd Affiliated Hospital, Harbin, China
    Mol Vis 15:2498-502. 2009
    To identify mutations within the TGFBI gene in a Chinese family with lattice corneal dystrophy type I (LCD I).
  52. ncbi Lattice corneal dystrophy type I without typical lattice lines: role of mutational analysis
    Shigeo Yoshida
    Department of Ophthalmology, Kyushu University Graduate School of Medicine, Fukuoka, Japan
    Am J Ophthalmol 137:586-8. 2004
    ..To describe a Japanese patient with lattice corneal dystrophy type I (LCD I) who lacked the typical lattice lines...
  53. ncbi A subset of patients with epithelial basement membrane corneal dystrophy have mutations in TGFBI/BIGH3
    Sandrine Boutboul
    Centre de Recherche Thérapeutique en Ophtalmologie CERTO, Faculté Necker Enfants Malades, Paris, France
    Hum Mutat 27:553-7. 2006
    ..as well as the analysis of single affected individuals; we identified two different point mutations in the TGFBI/BIGH3 genes, genes known to be associated with other corneal dystrophies...
  54. ncbi [A research on TGFBI gene mutations in Chinese families with corneal dystrophies]
    Yan hua Qi
    Department of Ophthalmology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150086 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:310-2. 2006
    To identify what kind of TGFBI gene mutation happening to Chinese patients with corneal dystrophies.
  55. pmc A novel phenotype-genotype relationship with a TGFBI exon 14 mutation in a pedigree with a unique corneal dystrophy of Bowman's layer
    Catherine E Wheeldon
    Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Mol Vis 14:1503-12. 2008
    ..CDB) belongs to a group of dystrophies associated with mutations in the transforming growth factor-beta-induced (TGFBI) gene...
  56. ncbi A novel H572R mutation in the transforming growth factor-beta-induced gene in a Thai family with lattice corneal dystrophy type I
    La ongsri Atchaneeyasakul
    Department of Ophthalmology, Siriraj Hospital Mahidol University, Bangkok, Thailand
    Jpn J Ophthalmol 50:403-8. 2006
    To describe a large Thai family with lattice corneal dystrophy (LCD) type I and to determine whether this LCD is associated with mutations within the transforming growth factor-beta-induced (TGFBI) gene.
  57. ncbi Spontaneous and inheritable R555Q mutation in the TGFBI/BIGH3 gene in two unrelated families exhibiting Bowman's layer corneal dystrophy
    Xinping C Zhao
    Department of Ophthalmology and Visual Science and Hermann Eye Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Ophthalmology 114:e39-46. 2007
    Bowman's layer corneal dystrophies (CDBs) include 2 distinct types: CDB1, or Reis-Bücklers (RBCD), and CDB2, or Thiel-Behnke (TBCD)...
  58. ncbi Phenotype associated with the H626P mutation and other changes in the TGFBI gene in Czech families
    Petra Liskova
    Division of Molecular Genetics, Institute of Ophthalmology, UCL, London, UK
    Ophthalmic Res 40:105-8. 2008
    To evaluate mutations in the transforming-growth-factor-beta-induced (TGFBI) gene in patients of Czech origin with autosomal dominant corneal dystrophies.
  59. ncbi A novel variant lattice corneal dystrophy caused by association of mutation (V625D) in TGFBI gene
    Xin Tian
    Department of Ophthalmology, Third Hospital, Peking University, Beijing, China
    Am J Ophthalmol 144:473-5. 2007
    To characterize the molecular defect in the TGFBI gene in a Chinese family affected with an atypical lattice corneal dystrophy.
  60. ncbi Lattice corneal dystrophy type III in patients with a homozygous L527R mutation in the TGFBI gene
    Tomoyo Funayama
    Jpn J Ophthalmol 50:62-4. 2006
  61. ncbi A unique corneal dystrophy of Bowman's layer and stroma associated with the Gly623Asp mutation in the transforming growth factor beta-induced (TGFBI) gene
    Anthony J Aldave
    Cornea Service, Jules Stein Eye Institute, University of California, Los Angeles, California 90095, USA
    Ophthalmology 112:1017-22. 2005
    To report a unique corneal dystrophy characterized by deposits at Bowman's layer and stromal lattice lines associated with the Gly623Asp missense mutation in the transforming growth factor beta-induced (TGFBI) gene.
  62. ncbi Two mutations in the TGFBI (BIGH3) gene associated with lattice corneal dystrophy in an extensively studied family
    Gordon K Klintworth
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 45:1382-8. 2004
    ..To determine the genetic basis for lattice corneal dystrophy (LCD) in an extensively studied family...
  63. ncbi Polymorphic corneal amyloidosis: a disorder due to a novel mutation in the transforming growth factor beta-induced (BIGH3) gene
    David E Eifrig
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
    Ophthalmology 111:1108-14. 2004
    ..To characterize the clinicopathologic phenotype as well as the molecular genetic basis of an autosomal dominant form of corneal amyloidosis...
  64. ncbi Unusual phenotype of an individual with the R124C mutation in the TGFBI gene
    Naoyuki Morishige
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Arch Ophthalmol 122:1224-7. 2004
  65. ncbi Lattice corneal dystrophy associated with the Ala546Asp and Pro551Gln missense changes in the TGFBI gene
    Anthony J Aldave
    Cornea Service, The Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Am J Ophthalmol 138:772-81. 2004
    To report a phenotypic variant of lattice corneal dystrophy associated with two missense changes, Ala546Asp and Pro551Gln, in the transforming growth factor-beta-induced gene (TGFBI).
  66. ncbi TGFBI gene mutation analysis in families with hereditary corneal dystrophies from Ukraine
    V M Pampukha
    Institute of Molecular Biology and Genetics, National Academy of Science of Ukraine, Kiev, Ukraine
    Ophthalmologica 218:411-4. 2004
    In our study, 5 previously reported mutations of the TGFBI gene - R124C, R124H, R124L (exon 4), R555W, R555Q (exon 12) - were analyzed using polymerase chain reaction followed by restriction digestion in 48 individuals from 19 unrelated ..
  67. pmc Anticipation in familial lattice corneal dystrophy type I with R124C mutation in the TGFBI (BIGH3) gene
    Pablo Romero
    Depto de Oftalmologia, Hospital Clínico José Joaquín Aguirre, Universidad de Chile, Santiago, Chile
    Mol Vis 14:829-35. 2008
    ..To report the clinical, ophthalmic, and genetic characteristics for lattice corneal dystrophy type I (LCDI) in a Chilean family...
  68. ncbi Beta ig-h3 mediates osteoblast adhesion and inhibits differentiation
    Narendra Thapa
    Institute of Cell and Matrix Biology Research, Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700 422, South Korea
    Bone 36:232-42. 2005
    ..We suggest that these interacting integrins may play an important role in betaig-h3-mediated inhibition of osteoblast differentiation...
  69. ncbi Novel mutation (V505D) of the TGFBI gene found in a Chinese family with lattice corneal dystrophy, type I
    Xin Tian
    Department of Ophthalmology, Third Hospital, Peking University, Beijing, China
    Jpn J Ophthalmol 49:84-8. 2005
    To report a novel V505D mutation of the human transforming growth factor beta-induced (TGFBI) gene found in a Chinese family with lattice corneal dystrophy, type I (LCDI).
  70. ncbi The TGFBI A546D mutation causes an atypical type of lattice corneal dystrophy
    Vicente Correa-Gomez
    Research Unit, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico
    Mol Vis 13:1695-700. 2007
    To report the clinical, molecular, and histopathological features of a distinct transforming growth factor-beta-induced (TGFBI) gene-linked amyloidotic corneal dystrophy exhibiting an unusual lattice pattern.
  71. ncbi Clinical outcome of eight BIGH3-linked corneal dystrophies
    Pierre Ellies
    Department of Ophthalmology, Hopital Hotel Dieu de Paris, 1 Place du Parvis Notre Dame, 75004 Paris, France
    Ophthalmology 109:793-7. 2002
    To determine whether the mutational pattern of BIGH3-linked corneal dystrophies (CDs) can accurately predict the clinical course of the disease and be helpful in planning adequate surgical treatment.
  72. ncbi Late-onset form of lattice corneal dystrophy caused by leu527Arg mutation of the TGFBI gene
    K Hirano
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Cornea 20:525-9. 2001
    To report two Japanese patients who were clinically diagnosed with late-onset and sporadic lattice corneal dystrophy (LCD) in whom a Leu527Arg mutation in the TGFBI gene was found.
  73. ncbi Kerato-epithelin mutations in four 5q31-linked corneal dystrophies
    F L Munier
    Unit of Molecular Genetics, CHUV, Lausanne, Switzerland
    Nat Genet 15:247-51. 1997
    Granular dystrophy Groenouw type I (CDGG1), Reis-Bücklers (CDRB), lattice type I (CDL1) and Avellino (ACD) are four 5q31-linked human autosomal dominant corneal dystrophies...
  74. ncbi Histologic phenotype-genotype correlation of corneal dystrophies associated with eight distinct mutations in the TGFBI gene
    P Dighiero
    Department of Ophthalmology, Hotel Dieu Hospital, Paris, France
    Ophthalmology 108:818-23. 2001
    ..To establish a phenotype-genotype correlation of various autosomal-dominant corneal dystrophies among French subjects...
  75. ncbi Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen
    K Hashimoto
    Department of Removal Prosthodontics, School of Dentistry, Hiroshima University, Japan
    Biochim Biophys Acta 1355:303-14. 1997
    ..Since RGD-CAP transcripts were found in most tissues, this novel collagen-binding protein may play an important role in cell-collagen interactions in various tissues including developing cartilage...
  76. pmc A kerato-epithelin (betaig-h3) mutation in lattice corneal dystrophy type IIIA
    S Yamamoto
    Am J Hum Genet 62:719-22. 1998
  77. ncbi Two distinct kerato-epithelin mutations in Reis-Bücklers corneal dystrophy
    M Okada
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Ophthalmol 126:535-42. 1998
    ..To see whether there was a genetic basis for these phenotypic variations, we analyzed beta ig-h3, the gene that codes for kerato-epithelin and that contains a mutation (Arg555Gln) that causes RBCD...
  78. ncbi Association of autosomal dominantly inherited corneal dystrophies with BIGH3 gene mutations in Japan
    Y Mashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 130:516-7. 2000
    To evaluate the incidence of BIGH3 gene mutations in 164 unrelated Japanese patients with corneal stromal dystrophies with an autosomal dominant trait.
  79. ncbi Heterogeneity in granular corneal dystrophy: identification of three causative mutations in the TGFBI (BIGH3) gene-lessons for corneal amyloidogenesis
    H S Stewart
    Department of Medical Genetics and Regional Genetics Service, St Mary s Hospital, Manchester, UK
    Hum Mutat 14:126-32. 1999
    Six autosomal dominant corneal dystrophies are caused by mutations in the TGFBI (BIGH3) gene on chromosome 5q31: three types of lattice corneal dystrophy (LCD), including type I and type IIIA, granular, Avellino (ACD), and Reis-Bucklers...
  80. ncbi A common beta ig-h3 gene mutation (delta f540) in a large cohort of Sardinian Reis Bücklers corneal dystrophy patients. Mutations in brief no. 180. Online
    C Rozzo
    Istituto di Genetica Molecolare, C N R, Alghero, Italy
    Hum Mutat 12:215-6. 1998
    ..Recently RBCD, together with lattice corneal dystrophy type I (LCDI), granular corneal dystrophy (CDGG1) and Avellino stromal dystrophy (ASD), all mapped on 5q31, were found to be associated to four different mutations ..
  81. pmc Corneal amyloidosis caused by Leu518Pro mutation of betaig-h3 gene
    K Hirano
    Department of Ophthalmology, Nagoya University School of Medicine, Aichi, Japan
    Br J Ophthalmol 84:583-5. 2000
    ..To report a Japanese family diagnosed clinically as having lattice corneal dystrophy type I (LCDI) in which a Leu518Pro mutation in the betaig-h3 gene and not the R124C mutation reported previously was found...
  82. ncbi A novel variant of granular corneal dystrophy caused by association of 2 mutations in the TGFBI gene-R124L and DeltaT125-DeltaE126
    P Dighiero
    Laboratoire de Biochimie et Genetique Moleculaire, 123 boulevard du Port Royal, 75014 Paris, France
    Arch Ophthalmol 118:814-8. 2000
    To characterize the molecular defect in the TGFBI gene in a French family affected with an atypical granular corneal dystrophy.
  83. ncbi Three autosomal dominant corneal dystrophies map to chromosome 5q
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City 52242
    Nat Genet 6:47-51. 1994
    ..The maximum combined lod score using all 114 affected patients was 28.6 with marker D5S393. None of the 14 known human amyloid-associated genes map to chromosome 5...
  84. ncbi BIGH3 mutation spectrum in corneal dystrophies
    Francis L Munier
    Hopital Jules Gonin, Department of Ophthalmology, Lausanne, Switzerland
    Invest Ophthalmol Vis Sci 43:949-54. 2002
    To investigate the molecular pathology underlying BIGH3-related corneal dystrophies (CDs) and to further delineate genotype-phenotype specificity.
  85. ncbi Molecular properties of wild-type and mutant betaIG-H3 proteins
    Jung Eun Kim
    Department of Biochemistry, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Taegu, 700 422 Korea
    Invest Ophthalmol Vis Sci 43:656-61. 2002
    ..To understand the mechanisms of protein deposits in 5q31-linked corneal dystrophies, the molecular properties of betaIG-H3 and the effects of mutation on these properties were studied in vitro...
  86. ncbi Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM
    Mark Aitkenhead
    Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697, USA
    Microvasc Res 63:159-71. 2002
    ..These data expand the suite of genes implicated in vascular remodeling and angiogenesis...
  87. ncbi beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice
    J Skonier
    Bristol Myers Squibb, Pharmaceutical Research Institute Seattle, WA 98121
    DNA Cell Biol 13:571-84. 1994
    ..The corresponding mouse beta ig-h3 gene was mapped to mouse chromosome 13 region B to C1, which confirms a region of conservation on human chromosome 5 and mouse chromosome 13. We suggest that this protein be named p68 beta ig-h3...
  88. ncbi R124C mutation of the betaIGH3 gene leads to remarkable phenotypic variability in a Greek four-generation family with lattice corneal dystrophy type 1
    Y Hellenbroich
    Institut fur Humangenetik, Universitatsklinikum Lubeck, Deutschland
    Ophthalmologica 215:444-7. 2001
    ..The resulting data revealed no association with the variable clinical course...
  89. ncbi cDNA from human ocular ciliary epithelium homologous to beta ig-h3 is preferentially expressed as an extracellular protein in the corneal epithelium
    J Escribano
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510
    J Cell Physiol 160:511-21. 1994
    ....
  90. ncbi Cat scratch disease and acquired immunodeficiency disease: diagnosis by transmission electron microscopy
    J G Guccion
    Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Washington, DC, USA
    Ultrastruct Pathol 20:195-202. 1996
    ..The diagnosis of cat scratch disease (CSD) became apparent only after transmission electron microscopic study of the lymph node revealed clusters of small, ..
  91. ncbi [Serological cross-reaction among Bartonella henselae, Chlamydia pneumoniae and Coxiella burnetii by indirect fluorescence antibody method]
    H Tsuneoka
    Department of Clinical Laboratory, Yamaguchi-ken Kouseiren Nagato General Hospital
    Kansenshogaku Zasshi 75:406-10. 2001
    ..burnetii by indirect fluorescence antibody (IFA) method, using sera from 8 patients with cat scratch disease (CSD), 13 patients with C. pneumoniae infection and 12 patients with acute Q fever. B...
  92. ncbi Downregulation of human polymorphonuclear cell activities exerted by microorganisms belonging to the alpha-2 subgroup of Proteobacteria (Afipia felis and Rochalimaea henselae)
    D Fumarola
    Institutes of Medical Microbiology, General Pathology, University of Bari, Italy
    Immunopharmacol Immunotoxicol 16:449-61. 1994
    ..A. falis has been previously proposed as the causative agent of Cat Scratch Disease (CSD), but several recent lines of evidence attribute a major role to R. henselae...
  93. ncbi [A study on wounds caused by cats as basic materials of cat scratch disease]
    Y Arashima
    Department of Clinical Pathology, Nihon University School of Medicine
    Kansenshogaku Zasshi 68:734-9. 1994
    ..Their injuries clearly differed from those of the other groups. In our survey 33 cases were suspected to have CSD; 19 of 102 veterinarians, 4 of 45 veterinary technicians, 2 of 517 students of veterinary college, 1 of 400 ..
  94. ncbi [Bartonella henselae as a cause of optical nerve neuritis]
    Dragan Veselinović
    Klinicki centar, Klinika za ocne bolesti, Nis, Srbija
    Vojnosanit Pregl 63:971-4. 2006
    ..included into the group of gram-negative bacteria that can cause not so rare disease known as cat-scratch disease (CSD)...
  95. ncbi [Two patients with Bartonella henselae infection from a dog]
    I Murano
    Department of Pediatrics, Yamaguchi Prefectural Central Hospital
    Kansenshogaku Zasshi 75:808-11. 2001
    ..Careful review of suspected CSD victims' history of contact with animals is important in making a prompt diagnosis of B. henselae infection.
  96. ncbi Cervical lymphadenitis and cat scratch disease (CSD): an overlooked disease?
    P Rombaux
    Department of Otolaryngology Head and Neck Surgery, Universite Catholique de Louvain, Saint Luc University Hospital, Brussels, Belgium
    Acta Otorhinolaryngol Belg 54:491-6. 2000
    Cat Scratch Disease (CSD) is a benign disease characterized by regional lymphadenopathy affecting most frequently the head and neck region in children and young adults...
  97. ncbi [Cardiovascular impact of end-stage renal insufficiency in children undergoing hemodialysis]
    Y Aggoun
    , , Paris
    Arch Mal Coeur Vaiss 93:1009-13. 2000
    ..the wall (intima-media thickness, IMT), the cross sectional compliance (CSC), the cross sectional distensibility (CSD) and the (Einc) were determined. CSC and CSD were evaluated at the same level of pressure...
  98. ncbi [Early recurrence of Groenouw type I corneal dystrophy after phototherapeutic keratectomy. Molecular biology study suggests epithelial genesis]
    F Chiambaretta
    Service d Ophtalmologie, Hopital Gabriel Montpied, BP 69, Clermont Ferrand Cedex, France
    J Fr Ophtalmol 27:449-56. 2004
    ..corneal dystrophy Groenouw type 1 (GGI) is a rare autosomal dominant disease caused by allelic mutations of the BIGH3 gene...
  99. ncbi [Determination of anti-Bartonella henselae antibody by indirect fluorescence antibody test--comparison of two types of antigen: non-cocultivated B. henselae and cocultivated B. henselae with Vero cells]
    H Tsuneoka
    Department of Clinical Laboratory, Yamaguchi-ken Kouseiren Nagato General Hospital
    Kansenshogaku Zasshi 72:801-7. 1998
    Serum anti-Bartonella henselae IgG and IgM antibody titers for the diagnosis of cat scratch disease (CSD) were determined by indirect fluorescence antibody (IFA) tests. B...
  100. pmc Seroprevalence of antibodies to Bartonella henselae in patients with cat scratch disease and in healthy controls: evaluation and comparison of two commercial serological tests
    A Sander
    Abteilung Mikrobiologie und Hygiene, Institut fur Medizinische Mikrobiologie und Hygiene, Klinikum der Universität Freiburg, Germany
    Clin Diagn Lab Immunol 5:486-90. 1998
    ..is a widely accepted diagnostic procedure for laboratory confirmation of the diagnosis of cat scratch disease (CSD). In this study a commercially available indirect immunofluorescence assay (IFA) based on B...

Research Grants82

  1. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    Jerome Engel; Fiscal Year: 2002
    ..In the course of these experiments we will utilize current source density (CSD) and voltage depth profile analysis, and single unit recording in both rats and patients...
  2. QUANTITATIVE ANALYSIS OF LEFT VENTRICULOPLASTY--CHF
    Mark Ratcliffe; Fiscal Year: 2009
    ..on akinetic infarcts), passive constraint device procedures such as the Acorn CorCapTM Cardiac Support Device (CSD), and cell transplantation are currently being performed...
  3. BIGH3 Wild-Type and Mutant Proteins
    GORDON KENNETH KLINTWORTH; Fiscal Year: 2010
    ..Mutations in the TGFBI (BIGH3) gene are responsible for several phenotypically different inherited corneal diseases that have no apparent non-..
  4. BIGH3 Wild-Type and Mutant Proteins
    Gordon Klintworth; Fiscal Year: 2009
    ..Mutations in the TGFBI (BIGH3) gene are responsible for several phenotypically different inherited corneal diseases that have no apparent non-..
  5. NHE3 Polymorphisms and Chronic Diarrheal Diseases
    Xinjun Zhu; Fiscal Year: 2013
    ..of NHE3 at a polymorphic site R474K in 2 of 3 patients with chronic diarrhea due to congenital sodium diarrhea (CSD) and this mutant failed to respond to dexamethasone...
  6. NHE3 Polymorphisms and Chronic Diarrheal Diseases
    Xinjun Zhu; Fiscal Year: 2013
    ..of NHE3 at a polymorphic site R474K in 2 of 3 patients with chronic diarrhea due to congenital sodium diarrhea (CSD) and this mutant failed to respond to dexamethasone...
  7. MOLECULAR CHARACTERIZATION OF ROCHALIMAEA ANTIGENS
    Burt Anderson; Fiscal Year: 1999
    ..proteins; and 3) evaluating the recombinant antigens as diagnostic reagents for BA and cat-scratch disease (CSD). The basic approach will be to screen recombinant gene libraries of R. henselae and R...
  8. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2010
    b>bIGH3 (keratoepithelin) is a constituent of the extracellular matrix (ECM) responsible for cell adhesion...
  9. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew Huang; Fiscal Year: 2009
    b>bIGH3 (keratoepithelin) is a constituent of the extracellular matrix (ECM) responsible for cell adhesion...
  10. FUNCTIONAL PROPERTIES OF HUMAN P68 (BIG H3) PROTEIN IN CORNEA
    RICHARD LEBARON; Fiscal Year: 1999
    The protein P68/BIGH3 (p68) is secreted to the extracellular space of corneal cells. This protein has two clusters of basic amino acids, an Arg- Gly-Asp sequence and fasciclin 1-like repeats...
  11. The biochemical correlates of sleep homeostasis
    Anna Kalinchuk; Fiscal Year: 2013
    ..Our PD show that iNOS blocking reverses SD-induced effects. SA4. To investigate whether chronic SD (CSD) triggers iNOS NO AD cascade in the BF and PFC/FC...
  12. Sensory plasticity in migraine
    KEVIN CHRISTOPHER BRENNAN; Fiscal Year: 2013
    ..We have identified changes in brain sensory responses after cortical spreading depression (CSD), a wave of brain activity that is thought to underlie the migraine aura...
  13. Haplotype-based analysis methods for population genomics
    John Novembre; Fiscal Year: 2013
    ..Finally, we will derive a novel form of the conditional sampling distribution (CSD) for a haplotype...
  14. FUNCTIONS OF NICOTINE RECEPTORS IN SENSORY NEOCORTEX
    Raju Metherate; Fiscal Year: 2013
    ..determine how activation of nAChRs alters spectral integration in A1, using tone-evoked current- source density (CSD) profiles to determine frequency RFs...
  15. Gene therapy in the cornea
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2010
    ..can be used to develop animal models for studying the specific function of disease-causing genes such as TGF and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...
  16. Gene therapy in the cornea
    RAJIV MOHAN; Fiscal Year: 2007
    ..be used to develop animal models for studying the specific function of disease-causing genes such as TGF¿ and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...
  17. Gene therapy in the cornea
    RAJIV MOHAN; Fiscal Year: 2009
    ..can be used to develop animal models for studying the specific function of disease-causing genes such as TGF and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...
  18. Gene therapy in the cornea
    RAJIV MOHAN; Fiscal Year: 2007
    ..can be used to develop animal models for studying the specific function of disease-causing genes such as TGFp and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...
  19. Gene therapy in the cornea
    RAJIV MOHAN; Fiscal Year: 2009
    ..can be used to develop animal models for studying the specific function of disease-causing genes such as TGF and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...
  20. Gene therapy in the cornea
    RAJIV MOHAN; Fiscal Year: 2009
    ..can be used to develop animal models for studying the specific function of disease-causing genes such as TGF and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...
  21. Defining a Role for c-KIT in Melanoma
    MATTHEW WAYNE VANBROCKLIN; Fiscal Year: 2013
    ..However, there are distinct subtypes of melanoma including chronic sun damaged (CSD), acral, and mucosal that rarely harbor BRAF mutations...
  22. Activation of the Trigeminovascular Pathway
    Rami Burstein; Fiscal Year: 2011
    Activation of the trigeminovascular pathway: functional relationship with CSD, dural mast cells,and parasympathetic innervation of the dura...
  23. Mechanism of Medication Overuse Headache and Chronic Migraine Pain
    Frank Porreca; Fiscal Year: 2013
    ..unknown, an important theory suggests that migraine may occur as a consequence of cortical spreading depression (CSD)...
  24. Mechanism of Medication Overuse Headache and Chronic Migraine Pain
    Frank Porreca; Fiscal Year: 2010
    ..unknown, an important theory suggests that migraine may occur as a consequence of cortical spreading depression (CSD)...
  25. MIGRAINE DRUG PROPHYLAXIS
    Michael Moskowitz; Fiscal Year: 2006
    ..that chronic daily administration of each drug suppressed the susceptibility to cortical spreading depression (CSD), a poorly understood, slowly propagating electrophysiological event...
  26. MIGRAINE DRUG PROPHYLAXIS
    Michael Moskowitz; Fiscal Year: 2007
    ..that chronic daily administration of each drug suppressed the susceptibility to cortical spreading depression (CSD), a poorly understood, slowly propagating electrophysiological event...
  27. TRIGGERING MECHANISMS FOR MIGRANINE HEADACHE
    MOSKOWITZ MICHAEL; Fiscal Year: 2006
    ..We recently demonstrated that cortical spreading depression (CSD) an intrinsic brain parencymal event underlying migraine visual aura initiates a cascade of events in the overlying ..
  28. TRIGGERING MECHANISMS FOR MIGRANINE HEADACHE
    MOSKOWITZ MICHAEL; Fiscal Year: 2005
    ..We recently demonstrated that cortical spreading depression (CSD) an intrinsic brain parencymal event underlying migraine visual aura initiates a cascade of events in the overlying ..
  29. TRIGGERING MECHANISMS FOR MIGRANINE HEADACHE
    MOSKOWITZ MICHAEL; Fiscal Year: 2004
    ..We recently demonstrated that cortical spreading depression (CSD) an intrinsic brain parencymal event underlying migraine visual aura initiates a cascade of events in the overlying ..
  30. Genetic Risk Factors for Visceral Leishmaniasis
    MARY EDYTHE contact WILSON; Fiscal Year: 2010
    ..Aims of this RO1 are: 1. To test the hypothesis that candidate genes (SLC11A1, IL4-LECT2/TGFBI, HLA) determine susceptibility to cVL and to asymptomatic infection (DTH+) using dense tag-SNPs, with sample sizes ..
  31. Genetic Risk Factors for Visceral Leishmaniasis
    Mary Wilson; Fiscal Year: 2009
    ..Aims of this RO1 are: 1. To test the hypothesis that candidate genes (SLC11A1, IL4-LECT2/TGFBI, HLA) determine susceptibility to cVL and to asymptomatic infection (DTH+) using dense tag-SNPs, with sample sizes ..
  32. Surgery to Prevent Postinfarction Ventricular Remodeling
    Robert C Gorman; Fiscal Year: 2013
    ..therapeutic approaches to limit infarct expansion early after MI will be studied: heart wrapping with the Acorn CSD(R), infarct reperfusion and calcium hydroxyapatite microsphere gel injection...
  33. Surgery to Prevent Postinfarction Ventricular Remodeling
    Robert Gorman; Fiscal Year: 2009
    ..therapeutic approaches to limit infarct expansion early after MI will be studied: heart wrapping with the Acorn CSD(R), infarct reperfusion and calcium hydroxyapatite microsphere gel injection...
  34. Surgery to Prevent Postinfarction Ventricular Remodeling
    Robert C Gorman; Fiscal Year: 2010
    ..therapeutic approaches to limit infarct expansion early after MI will be studied: heart wrapping with the Acorn CSD(R), infarct reperfusion and calcium hydroxyapatite microsphere gel injection...
  35. Elucidation of a bacterial cell shape generating program and pathogenic functions
    NINA REDA SALAMA; Fiscal Year: 2013
    ..experimental support for this theory with the characterization of four cell shape determining genes (csd1, csd2, csd3, ccmA) that promote helical cell curvature and twist through changes in cell wall peptidoglycan (PG) crosslinking ..
  36. Curcumin Treatment of Lung Fibrosis: Improved Delivery and Target Cells
    Stanley R Hoffman; Fiscal Year: 2010
    ..Our studies on the mechanism of curcumin will take advantage of our recent work on another protective agent, CSD peptide, which has beneficial effects on at least five cell types...
  37. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 1991
    Cortical spreading depression (CSD) is a wave of depolarization that results in complex changes in pial arteriolar diameter, intense vasodilation lasting approximately 2 minutes, a return of diameter to baseline for several minutes, and ..
  38. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 2000
    Cortical spreading depression (CSD) is a wave of depolarization that results in complex changes in pial arteriolar diameter, intense vasodilation lasting approximately 2 minutes, a return of diameter to baseline for several minutes, and ..
  39. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 1999
    Cortical spreading depression (CSD) is a wave of depolarization that results in complex changes in pial arteriolar diameter, intense vasodilation lasting approximately 2 minutes, a return of diameter to baseline for several minutes, and ..
  40. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 2000
    Cortical spreading depression (CSD) is a wave of depolarization that results in complex changes in pial arteriolar diameter, intense vasodilation lasting approximately 2 minutes, a return of diameter to baseline for several minutes, and ..
  41. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 2001
    Cortical spreading depression (CSD) is a wave of depolarization that results in complex changes in pial arteriolar diameter, intense vasodilation lasting approximately 2 minutes, a return of diameter to baseline for several minutes, and ..
  42. Tools for migraine drug development
    KEVIN CHRISTOPHER BRENNAN; Fiscal Year: 2013
    ..multi-animal platform to increase the throughput and data-richness of the cortical spreading depression (CSD) model in vivo...
  43. SYNAPTIC SOURCES OF HIPPOCAMPAL THETA RHYTHM
    Steven Fox; Fiscal Year: 1991
    ..Secondly, current source density (CSD) measurements will be made in the hippocampus before and after a) lesioning anatomical sources of afferents, b) ..
  44. Mechanisms of CSD-evoked persistent activation of meningeal nociceptors
    Dan Levy; Fiscal Year: 2013
    ..Over the past two decades, evidence has gradually accumulated in support of the cortical spreading depression (CSD) theory of migraine, which proposes that CSD is the physiological event that underlies the visual aura that ..
  45. Caveolin-1 Regulates Monocyte-Fibrocyte Lineage Cell Functions via CXCR4
    Elena Tourkina; Fiscal Year: 2013
    ..of caveolin-1 as a key target in interstitial lung disease was validated using the caveolin-1 scaffolding domain (CSD) peptide, a peptide which mimics the function of full-length caveolin-1...
  46. Interdisciplinary Research Training in Speech-Language Disorders
    Susan Ellis Weismer; Fiscal Year: 2010
    There is a critical shortage of new PhD's in the field of Communication Sciences and Disorders (CSD)...
  47. Interdisciplinary Research Training in Speech-Language Disorders
    Susan Ellis Weismer; Fiscal Year: 2009
    There is a critical shortage of new PhD's in the field of Communication Sciences and Disorders (CSD)...
  48. Migraine Pathophysiology and Treatment Mechanisms
    Michael Moskowitz; Fiscal Year: 2010
    ..Project 1 proposes to examine cortical spreading depression (CSD) in rats and in genetically modified mice carrying the R192Q missense mutation in P/Q-type Ca+* channels found in ..
  49. QUANTITATIVE ANALYSIS OF LEFT VENTRICULOPLASTY--CHF
    Mark B Ratcliffe; Fiscal Year: 2013
    ..on akinetic infarcts), passive constraint device procedures such as the Acorn CorCapTM Cardiac Support Device (CSD), and cell transplantation are currently being performed...
  50. Genetic Risk Factors for Visceral Leishmaniasis
    Mary E Wilson; Fiscal Year: 2013
    ..Aims of this RO1 are: 1. To test the hypothesis that candidate genes (SLC11A1, IL4-LECT2/TGFBI, HLA) determine susceptibility to cVL and to asymptomatic infection (DTH+) using dense tag-SNPs, with sample sizes ..
  51. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2003
    ..high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid decarboxylase (CSD)...
  52. QUANTITATIVE ANALYSIS OF LEFT VENTRICULOPLASTY--CHF
    Mark B Ratcliffe; Fiscal Year: 2010
    ..on akinetic infarcts), passive constraint device procedures such as the Acorn CorCapTM Cardiac Support Device (CSD), and cell transplantation are currently being performed...
  53. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2002
    ..high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid decarboxylase (CSD)...
  54. NHE3 Polymorphisms and Chronic Diarrheal Diseases
    Xinjun Zhu; Fiscal Year: 2010
    ..of NHE3 at a polymorphic site R474K in 2 of 3 patients with chronic diarrhea due to congenital sodium diarrhea (CSD) and this mutant failed to respond to dexamethasone...
  55. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2001
    ..high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid decarboxylase (CSD)...
  56. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2000
    ..high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid decarboxylase (CSD)...
  57. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    Jerome Engel; Fiscal Year: 2001
    ..In the course of these experiments we will utilize current source density (CSD) and voltage depth profile analysis, and single unit recording in both rats and patients...
  58. SPEECH SOUND PROCESSING IN AUDITORY CORTEX
    Mitchell Steinschneider; Fiscal Year: 1990
    ..ensembles; multiple unit activity (MUA), auditory evoked potentials (AEPs) and the derived current source density (CSD)...
  59. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    Jerome Engel; Fiscal Year: 2000
    ..In the course of these experiments we will utilize current source density (CSD) and voltage depth profile analysis, and single unit recording in both rats and patients...
  60. Migraine Pathophysiology and Treatment Mechanisms
    Michael Moskowitz; Fiscal Year: 2009
    ..Project 1 proposes to examine cortical spreading depression (CSD) in normal and genetically modified mice and expand upon a recent novel finding that prophylactic antimigraine ..
  61. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    Jerome Engel; Fiscal Year: 1999
    ..In the course of these experiments we will utilize current source density (CSD) and voltage depth profile analysis, and single unit recording in both rats and patients...
  62. Migraine Pathophysiology and Treatment Mechanisms
    Michael Moskowitz; Fiscal Year: 2007
    ..Project 1 proposes to examine cortical spreading depression (CSD) in normal and genetically modified mice and expand upon a recent novel finding that prophylactic antimigraine ..
  63. PERSPECTIVES ON PRODUCTIVE AGING
    Nancy Morrow Howell; Fiscal Year: 1999
    ..Louis, MO. The Center for Social Development (CSD) at the George Warren Brown School of Social Work will host this event...
  64. Phase II Study of Imatinib Mesylate in Patients with Inoperable Melanoma
    Gary Schwartz; Fiscal Year: 2009
    ..skin on the palms and soles (acral melanomas), on mucosal membranes, and from skin with chronic sun-induced damage (CSD) have distinctive patterns of chromosomal alterations as compared with the more common subtypes of melanoma arising ..
  65. Phase II Study of Imatinib Mesylate in Patients with Inoperable Melanoma
    Gary K Schwartz; Fiscal Year: 2010
    ..skin on the palms and soles (acral melanomas), on mucosal membranes, and from skin with chronic sun-induced damage (CSD) have distinctive patterns of chromosomal alterations as compared with the more common subtypes of melanoma arising ..
  66. Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine Models
    Cenk Ayata; Fiscal Year: 2009
    ..migraine expressing human mutations in implicated genes, as well as data implicating cortical spreading depression (CSD) in migraine aura...
  67. Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine Models
    Cenk Ayata; Fiscal Year: 2010
    ..migraine expressing human mutations in implicated genes, as well as data implicating cortical spreading depression (CSD) in migraine aura...
  68. CRCNS: Integrated Empirical and Multiscale Modeling of Human Sleep Spindles
    Terrence Sejnowski; Fiscal Year: 2009
    ..2) Analyze the recorded cortical Current Source Density (CSD) using Principal Components Analysis (PCA)...
  69. CRCNS: Integrated Empirical and Multiscale Modeling of Human Sleep Spindles
    Terrence J Sejnowski; Fiscal Year: 2010
    ..2) Analyze the recorded cortical Current Source Density (CSD) using Principal Components Analysis (PCA)...
  70. CRCNS: Integrated Empirical and Multiscale Modeling of Human Sleep Spindles
    Terrence Sejnowski; Fiscal Year: 2009
    ..2) Analyze the recorded cortical Current Source Density (CSD) using Principal Components Analysis (PCA)...
  71. Cortical Spreading Depression, Proteases and Ischemia
    Michael Moskowitz; Fiscal Year: 2004
    Cortical spreading depression (CSD) develops during experimental stroke and within normal and traumatically-injured human brain...
  72. A Collaborative Study of Membranoproliferative Glomerulonephritis Type II
    Richard Smith; Fiscal Year: 2007
    ..can be documented in plasma by low APH 50 values, low Cs levels, and the appearance of the Cs degradation product Csd. Renal transplantation is associated with disease recurrence in virtually all allografts and a high percentage of ..
  73. A Collaborative Study of Membranoproliferative Glomerulonephritis Type II
    Richard J Smith; Fiscal Year: 2010
    ..can be documented in plasma by low APH 50 values, low Cs levels, and the appearance of the Cs degradation product Csd. Renal transplantation is associated with disease recurrence in virtually all allografts and a high percentage of ..
  74. INFORMATION PROCESSING DEFICITS IN SCHIZOTYPAL PATIENTS
    Kristin Cadenhead; Fiscal Year: 1999
    ..measures of visual information processing, including visual backward masking (VBM) and critical stimulus duration (CSD)...
  75. A Collaborative Study of Membranoproliferative Glomerulonephritis Type II
    Richard Smith; Fiscal Year: 2009
    ..can be documented in plasma by low APH 50 values, low Cs levels, and the appearance of the Cs degradation product Csd. Renal transplantation is associated with disease recurrence in virtually all allografts and a high percentage of ..