TGFBI

Summary

Gene Symbol: TGFBI
Description: transforming growth factor, beta-induced, 68kDa
Alias: BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1, RGD-CAP, RGD-containing collagen-associated protein, beta ig-h3, kerato-epithelin, transforming growth factor-beta-induced protein ig-h3
Species: human

Top Publications

  1. ncbi Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro
    R G LeBaron
    Division of Life Sciences, University of Texas at San Antonio, USA
    J Invest Dermatol 104:844-9. 1995
  2. ncbi IgM to Bartonella henselae in cat-scratch disease and during acute Epstein-Barr virus infection
    R Zbinden
    Department of Medical Microbiology, University of Zurich, Switzerland
    Med Microbiol Immunol 186:167-70. 1998
  3. ncbi [Arterial dysfunction after treatment of coarctation of the aorta]
    Y Aggoun
    , 149, , 75743 Paris
    Arch Mal Coeur Vaiss 94:785-9. 2001
  4. ncbi BIGH3 gene mutations and rapid detection in Korean patients with corneal dystrophy
    H S Kim
    Laboratory of Ophthalmology and Visual Science, Catholic Research Institutes of Medical Science, Catholic University Medical College, Seoul, Korea
    Cornea 20:844-9. 2001
  5. ncbi Effect of high-dose methyl-prednisolone on brainstem encephalopathy and basal ganglia impairment complicating cat scratch disease
    Jacob Genizi
    Child Neurology Unit and Epilepsy Service, Meyer Children Hospital, Rambam Medical Center, Rappaport School of Medicine, Haifa, Israel
    Brain Dev 29:377-9. 2007
  6. ncbi Analysis of TGFBI gene mutations in Chinese patients with corneal dystrophies and review of the literature
    Juhua Yang
    Biomedical Engineering Center, Fujian Medical University, Fuzhou, Fujian, China
    Mol Vis 16:1186-93. 2010
  7. ncbi Genotype-phenotype correlations of TGFBI p.Leu509Pro, p.Leu509Arg, p.Val613Gly, and the allelic association of p.Met502Val-p.Arg555Gln mutations
    Florence Niel-Butschi
    INSERM, U1016, Institut Cochin, CNRS, UMR 8104, Universite Paris Descartes, Paris, France
    Mol Vis 17:1192-202. 2011
  8. ncbi TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients
    S V V Kalyana Chakravarthi
    Kallam Anji Reddy Molecular Genetics Laboratory, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 46:121-5. 2005
  9. ncbi Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of avellino corneal dystrophy
    Sean L Edelstein
    Saint Louis University Eye Institute, Saint Louis University School of Medicine, Saint Louis, MO, USA
    Cornea 29:698-700. 2010
  10. ncbi TGFBI mutation screening and genotype-phenotype correlation in north Indian patients with corneal dystrophies
    Preeti Paliwal
    Laboratory of Cyto Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
    Mol Vis 16:1429-38. 2010

Research Grants

  1. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    Jerome Engel; Fiscal Year: 2002
  2. QUANTITATIVE ANALYSIS OF LEFT VENTRICULOPLASTY--CHF
    Mark Ratcliffe; Fiscal Year: 2009
  3. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2010
  4. BIGH3 Wild-Type and Mutant Proteins
    GORDON KENNETH KLINTWORTH; Fiscal Year: 2010
  5. Mechanism of Medication Overuse Headache and Chronic Migraine Pain
    Frank Porreca; Fiscal Year: 2010
  6. MIGRAINE DRUG PROPHYLAXIS
    Michael Moskowitz; Fiscal Year: 2007
  7. Genetic Risk Factors for Visceral Leishmaniasis
    MARY EDYTHE contact WILSON; Fiscal Year: 2010
  8. Surgery to Prevent Postinfarction Ventricular Remodeling
    Robert Gorman; Fiscal Year: 2009
  9. Surgery to Prevent Postinfarction Ventricular Remodeling
    Robert C Gorman; Fiscal Year: 2010
  10. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 2001

Detail Information

Publications226 found, 100 shown here

  1. ncbi Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro
    R G LeBaron
    Division of Life Sciences, University of Texas at San Antonio, USA
    J Invest Dermatol 104:844-9. 1995
    ..Finally, we show that recombinant beta IG-H3 supported attachment and spreading of dermal fibroblasts, suggesting that beta IG-H3 may function as an extracellular attachment protein in skin...
  2. ncbi IgM to Bartonella henselae in cat-scratch disease and during acute Epstein-Barr virus infection
    R Zbinden
    Department of Medical Microbiology, University of Zurich, Switzerland
    Med Microbiol Immunol 186:167-70. 1998
    The diagnostic value of IgM to Bartonella henselae was evaluated in 20 children with cat-scratch disease (CSD) and controls consisting of 20 blood donors and 20 children with enlarged lymph nodes without CSD by two indirect ..
  3. ncbi [Arterial dysfunction after treatment of coarctation of the aorta]
    Y Aggoun
    , 149, , 75743 Paris
    Arch Mal Coeur Vaiss 94:785-9. 2001
    ..of the common carotid artery (CCA) to define mechanical indexes: Cross sectional compliance (CSC), distensibility (CSD) and incremental elastic modulus (Einc) in each group...
  4. ncbi BIGH3 gene mutations and rapid detection in Korean patients with corneal dystrophy
    H S Kim
    Laboratory of Ophthalmology and Visual Science, Catholic Research Institutes of Medical Science, Catholic University Medical College, Seoul, Korea
    Cornea 20:844-9. 2001
    Mutations in the BIGH3 gene on chromosome 5q31 cause four distinct autosomal dominant corneal dystrophies. We sought to determine whether the BIGH3 gene mutation was responsible for corneal dystrophy in Korean patients.
  5. ncbi Effect of high-dose methyl-prednisolone on brainstem encephalopathy and basal ganglia impairment complicating cat scratch disease
    Jacob Genizi
    Child Neurology Unit and Epilepsy Service, Meyer Children Hospital, Rambam Medical Center, Rappaport School of Medicine, Haifa, Israel
    Brain Dev 29:377-9. 2007
    Cat scratch disease (CSD) is a zoonotic illness caused by the Gram negative bacillus Bartonella henselae characterized by a small skin lesion at the site of a bite, lick or scratch by a cat, commonly followed by regional lymphadenopathy ..
  6. ncbi Analysis of TGFBI gene mutations in Chinese patients with corneal dystrophies and review of the literature
    Juhua Yang
    Biomedical Engineering Center, Fujian Medical University, Fuzhou, Fujian, China
    Mol Vis 16:1186-93. 2010
    To analyze human transforming growth factor b-induced (TGFBI) gene mutations in Chinese patients with corneal dystrophies (CDs).
  7. ncbi Genotype-phenotype correlations of TGFBI p.Leu509Pro, p.Leu509Arg, p.Val613Gly, and the allelic association of p.Met502Val-p.Arg555Gln mutations
    Florence Niel-Butschi
    INSERM, U1016, Institut Cochin, CNRS, UMR 8104, Universite Paris Descartes, Paris, France
    Mol Vis 17:1192-202. 2011
    Investigate the genotype-phenotype correlations for five TGFBI (transforming growth factor, beta-induced) mutations including one novel pathogenic variant and one complex allele affecting the fourth FAS1 domain of keratoepithelin, and ..
  8. ncbi TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients
    S V V Kalyana Chakravarthi
    Kallam Anji Reddy Molecular Genetics Laboratory, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 46:121-5. 2005
    To identify mutations in the TGFBI gene in Indian patients with lattice corneal dystrophy (LCD) or granular corneal dystrophy (GCD) and to look for genotype-phenotype correlations.
  9. ncbi Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of avellino corneal dystrophy
    Sean L Edelstein
    Saint Louis University Eye Institute, Saint Louis University School of Medicine, Saint Louis, MO, USA
    Cornea 29:698-700. 2010
    ..To present a patient with a genotype usually associated with lattice corneal dystrophy but with clinical and histopathologic features of advanced Avellino corneal dystrophy...
  10. ncbi TGFBI mutation screening and genotype-phenotype correlation in north Indian patients with corneal dystrophies
    Preeti Paliwal
    Laboratory of Cyto Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
    Mol Vis 16:1429-38. 2010
    ..of corneal dystrophy patients from North India for mutations in the transforming growth factor beta induced (TGFBI) gene, to correlate genotypes to phenotypes, to describe structural implications of various mutations on protein ..
  11. ncbi Granular and lattice deposits in corneal dystrophy caused by R124C mutation of TGFBIp
    Dhara A Patel
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cornea 29:1215-22. 2010
    ..We investigated the presence of these deposits in other TGFBI mutations and the use of Thioflavin-T (ThT), a fluorescent amyloid stain for characterizing corneal amyloid ..
  12. ncbi TGFBI (BIGH3) gene mutations in German families: two novel mutations associated with unique clinical and histopathological findings
    C Gruenauer-Kloevekorn
    Department of Ophthalmology, Martin Luther University, Ernst Grube Strasse 40, 06097 Halle, Germany
    Br J Ophthalmol 93:932-7. 2009
    To report the clinical, histopathological and immunohistochemical findings of two novel mutations within the TGFBI gene.
  13. ncbi Allelic homogeneity due to a founder mutation in Japanese patients with lattice corneal dystrophy type IIIA
    Kaoru Tsujikawa
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Med Genet 113:20-2. 2002
    Lattice corneal dystrophies (LCDs) are caused by mutations of the transforming growth factor beta-induced gene (TGFBI, formerly betaig-h3). LCD type IIIA (LCDIIIA) has been reported mostly from Japan...
  14. ncbi TGFBI mutational analysis in a New Zealand population of inherited corneal dystrophy patients
    Andrea L Vincent
    Department of Ophthalmology, Faculty of Medical and Health Sciences, National Eye Centre, University of Auckland, Auckland, New Zealand
    Br J Ophthalmol 94:836-42. 2010
    ..Mutations in the transforming growth factor beta-induced (TGFBI) gene segregate with a wide range of phenotypically heterogeneous corneal dystrophies...
  15. ncbi Clinical and genetic features of TGFBI-linked corneal dystrophies in Mexican population: description of novel mutations and novel genotype-phenotype correlations
    Juan Carlos Zenteno
    Department of Biochemistry, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
    Exp Eye Res 89:172-7. 2009
    ..Most CDs are inherited in an autosomal dominant fashion and mutations in the TGFBI gene at chromosome 5q31 cause the majority of CDs affecting the stromal layer...
  16. ncbi Arg124Cys mutation of the TGFBI gene in 2 Chinese families with Thiel-Behnke corneal dystrophy
    Liu Chang
    Beijing Tongren Ophthalmic Center, Beijing Institute of Ophthalmology, Capital University of Medical Sciences, Beijing, China
    Arch Ophthalmol 127:641-4. 2009
    To analyze transforming growth factor beta-induced (TGFBI) gene mutations in 2 Chinese families with Thiel-Behnke corneal dystrophy (TBCD).
  17. ncbi Reduced penetrance in familial Avellino corneal dystrophy associated with TGFBI mutations
    Wenping Cao
    Eye Hospital, The First Affiliated Hospital, Harbin Medical University, Harbin, China
    Mol Vis 15:70-5. 2009
    ..To characterize the clinical phenotype, histopathological features, and molecular genetic basis of an Avellino corneal dystrophy (ACD) in a Chinese family...
  18. ncbi Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation
    Chaoyu Ma
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 22:308-21. 2008
    ..Here we report that elevated expression of betaig-h3/TGFBI (transforming growth factor, beta-induced), an extracellular matrix protein secreted by colon cancer cells, is ..
  19. ncbi Genotype-phenotype correlation in 2 Indian families with severe granular corneal dystrophy
    Chitra Kannabiran
    Kallam Anji Reddy Molecular Genetics Laboratory and Ophthalmic Pathology Service, Professor Brien Holden Eye Research Centre, L V Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad 500 034, India
    Arch Ophthalmol 123:1127-33. 2005
    ..To determine genotypes in 2 Indian families with severe granular corneal dystrophy, to document clinical and histopathologic features, and to attempt a genotype-phenotype correlation...
  20. ncbi Clinical and genetic profile of Avellino corneal dystrophy in 2 families from north India
    Preeti Paliwal
    Laboratory of Cyto Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi
    Arch Ophthalmol 127:1373-6. 2009
    ..To report Avellino corneal dystrophy and underlying R124H mutation in 2 families of Indian origin...
  21. ncbi Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp
    Kasper Runager
    Center for Insoluble Protein Structures, Department of Molecular Biology, Aarhus University, 8000 Aarhus, Denmark
    J Biol Chem 286:4951-8. 2011
    Mutations in the human TGFBI gene encoding TGFBIp have been linked to protein deposits in the cornea leading to visual impairment. The protein consists of an N-terminal Cys-rich EMI domain and four consecutive fasciclin 1 (FAS1) domains...
  22. ncbi TL1A induces the expression of TGF-β-inducible gene h3 (βig-h3) through PKC, PI3K, and ERK in THP-1 cells
    Seung Hee Lee
    Kyungpook National University, Daegu, Republic of Korea
    Cell Immunol 266:61-6. 2010
    ....
  23. ncbi An R124C mutation in TGFBI caused lattice corneal dystrophy type I with a variable phenotype in three Chinese families
    Zhe Liu
    Department of Ophthalmology, Medical College of Zhejiang University, Hangzhou, China
    Mol Vis 14:1234-9. 2008
    ..A genetic and clinical study of three unrelated Chinese pedigrees with a variable phenotype of lattice corneal dystrophy type I (LCD I)...
  24. ncbi TGFBI gene mutation in a Chinese pedigree with Reis-Bücklers corneal dystrophy
    Qingfeng Liang
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Ophthalmic Physiol Opt 32:74-80. 2012
    To characterize the molecular defects in the TGFBI gene in a Chinese family with Reis-Bücklers corneal dystrophy (RBCD), and to study the relationship between the gene mutations and the clinical manifestations.
  25. ncbi A corneal dystrophy associated with transforming growth factor beta-induced Gly623Asp mutation an amyloidogenic phenotype
    Claudia Auw-Haedrich
    University Eye Hospital, Freiburg, Germany
    Ophthalmology 116:46-51. 2009
    To present the light and electron microscopic findings of a unique corneal dystrophy never before described in a German family carrying the Gly623Asp Mutation of the TGFBI gene with late clinical onset.
  26. ncbi Transforming growth factor-beta-inducible gene-h3 (beta(ig)-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of alpha6beta4 integrin
    Mi Ok Kim
    Graduate School of East West Medical Science, Kyung Hee University, 1 Seochun, Yong In 449 701, South Korea
    Neurosci Lett 336:93-6. 2003
    ....
  27. ncbi Covalent and non-covalent interactions of betaig-h3 with collagen VI. Beta ig-h3 is covalently attached to the amino-terminal region of collagen VI in tissue microfibrils
    Eric Hanssen
    Department of Pathology, University of Adelaide, South Australia, 5005, Australia
    J Biol Chem 278:24334-41. 2003
    ..Overall the study supports the concept that betaig-h3 is extensively associated with collagen VI in some tissues and that it plays an important modulating role in collagen VI microfibril function...
  28. ncbi A new L527R mutation of the betaIGH3 gene in patients with lattice corneal dystrophy with deep stromal opacities
    K Fujiki
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Hum Genet 103:286-9. 1998
    ..We conclude that there are now at least six different mutations that have been detected in the betaIGH3 gene on chromosome 5q31 and that lead to corneal dystrophy...
  29. ncbi TGFBI gene mutations in Brazilian patients with corneal dystrophy
    H P Solari
    Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Eye (Lond) 21:587-90. 2007
    To investigate the transforming growth factor beta-induced gene (TGFBI) mutations in Brazilian patients with corneal dystrophy and to evaluate the phenotype-genotype correlation in these patients.
  30. ncbi The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin
    Paul C Billings
    Department of Orthopedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28003-9. 2002
    ..Our results identify FN and Col I as two ligands of (beta)ig-h3 in the ECM...
  31. ncbi TGFBI gene mutation analysis in families with hereditary corneal dystrophies from Ukraine
    V M Pampukha
    Institute of Molecular Biology and Genetics, National Academy of Science of Ukraine, Kiev, Ukraine
    Ophthalmologica 218:411-4. 2004
    In our study, 5 previously reported mutations of the TGFBI gene - R124C, R124H, R124L (exon 4), R555W, R555Q (exon 12) - were analyzed using polymerase chain reaction followed by restriction digestion in 48 individuals from 19 unrelated ..
  32. ncbi Identification of the alphavbeta3 integrin-interacting motif of betaig-h3 and its anti-angiogenic effect
    Ju Ock Nam
    Cell and Matrix Biology National Research Laboratory, Department of Biochemistry, Kyungpook National University School of Medicine, Taegu 700 422, Korea
    J Biol Chem 278:25902-9. 2003
    ..Our results reveal that betaig-h3 bears alphavbeta3 integrin-interacting motifs that mediate endothelial cell adhesion and migration and, therefore, may regulate angiogenesis...
  33. ncbi Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose
    Suk Hee Lee
    Cell and Matrix Biology, National Research Laboratory, Kyungpook National University, Taegu, Korea
    Kidney Int 64:1012-21. 2003
    ..TGF-beta is believed to be involved in the development of diabetic nephropathy and thus we have assessed the possibility that betaig-h3 may be a downstream molecule in this pathogenic process...
  34. ncbi Beta ig-h3 mediates osteoblast adhesion and inhibits differentiation
    Narendra Thapa
    Institute of Cell and Matrix Biology Research, Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700 422, South Korea
    Bone 36:232-42. 2005
    ..We suggest that these interacting integrins may play an important role in betaig-h3-mediated inhibition of osteoblast differentiation...
  35. ncbi Novel mutation (V505D) of the TGFBI gene found in a Chinese family with lattice corneal dystrophy, type I
    Xin Tian
    Department of Ophthalmology, Third Hospital, Peking University, Beijing, China
    Jpn J Ophthalmol 49:84-8. 2005
    To report a novel V505D mutation of the human transforming growth factor beta-induced (TGFBI) gene found in a Chinese family with lattice corneal dystrophy, type I (LCDI).
  36. ncbi A unique corneal dystrophy of Bowman's layer and stroma associated with the Gly623Asp mutation in the transforming growth factor beta-induced (TGFBI) gene
    Anthony J Aldave
    Cornea Service, Jules Stein Eye Institute, University of California, Los Angeles, California 90095, USA
    Ophthalmology 112:1017-22. 2005
    To report a unique corneal dystrophy characterized by deposits at Bowman's layer and stromal lattice lines associated with the Gly623Asp missense mutation in the transforming growth factor beta-induced (TGFBI) gene.
  37. ncbi A novel mutation of the TGFBI gene found in a Vietnamese family with atypical granular corneal dystrophy
    Nguyen Thanh Ha
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 47:246-8. 2003
    Mutation of the human transforming growth factor beta-induced (TGFBI) gene causes granular corneal dystrophy (GCD) in various ethnic groups...
  38. ncbi Late-onset form of lattice corneal dystrophy caused by leu527Arg mutation of the TGFBI gene
    K Hirano
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Cornea 20:525-9. 2001
    To report two Japanese patients who were clinically diagnosed with late-onset and sporadic lattice corneal dystrophy (LCD) in whom a Leu527Arg mutation in the TGFBI gene was found.
  39. ncbi Histologic phenotype-genotype correlation of corneal dystrophies associated with eight distinct mutations in the TGFBI gene
    P Dighiero
    Department of Ophthalmology, Hotel Dieu Hospital, Paris, France
    Ophthalmology 108:818-23. 2001
    ..To establish a phenotype-genotype correlation of various autosomal-dominant corneal dystrophies among French subjects...
  40. ncbi RGD peptides released from beta ig-h3, a TGF-beta-induced cell-adhesive molecule, mediate apoptosis
    Jung Eun Kim
    Department of Biochemistry, Kyungpook National University School of Medicine, Taegu, Korea
    Oncogene 22:2045-53. 2003
    ..The anti-beta ig-h3 antibody blocks TGF-beta-induced apoptosis. Thus, beta ig-h3 may be important in regulating cell apoptosis by providing soluble RGD peptides...
  41. ncbi Lattice corneal dystrophy type I without typical lattice lines: role of mutational analysis
    Shigeo Yoshida
    Department of Ophthalmology, Kyushu University Graduate School of Medicine, Fukuoka, Japan
    Am J Ophthalmol 137:586-8. 2004
    ..To describe a Japanese patient with lattice corneal dystrophy type I (LCD I) who lacked the typical lattice lines...
  42. ncbi Lattice corneal dystrophy associated with the Ala546Asp and Pro551Gln missense changes in the TGFBI gene
    Anthony J Aldave
    Cornea Service, The Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Am J Ophthalmol 138:772-81. 2004
    To report a phenotypic variant of lattice corneal dystrophy associated with two missense changes, Ala546Asp and Pro551Gln, in the transforming growth factor-beta-induced gene (TGFBI).
  43. ncbi Unusual phenotype of an individual with the R124C mutation in the TGFBI gene
    Naoyuki Morishige
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
    Arch Ophthalmol 122:1224-7. 2004
  44. ncbi Identification of motifs in the fasciclin domains of the transforming growth factor-beta-induced matrix protein betaig-h3 that interact with the alphavbeta5 integrin
    Jung Eun Kim
    Cell and Matrix Biology National Research Laboratory, Department of Biochemistry, Kyungpook National University School of Medicine, Taegu 700 422, Korea
    J Biol Chem 277:46159-65. 2002
    ..This suggests that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins...
  45. ncbi R124C mutation of the betaIGH3 gene leads to remarkable phenotypic variability in a Greek four-generation family with lattice corneal dystrophy type 1
    Y Hellenbroich
    Institut fur Humangenetik, Universitatsklinikum Lubeck, Deutschland
    Ophthalmologica 215:444-7. 2001
    ..The resulting data revealed no association with the variable clinical course...
  46. ncbi Polymorphic corneal amyloidosis: a disorder due to a novel mutation in the transforming growth factor beta-induced (BIGH3) gene
    David E Eifrig
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
    Ophthalmology 111:1108-14. 2004
    ..To characterize the clinicopathologic phenotype as well as the molecular genetic basis of an autosomal dominant form of corneal amyloidosis...
  47. ncbi Clinical outcome of eight BIGH3-linked corneal dystrophies
    Pierre Ellies
    Department of Ophthalmology, Hopital Hotel Dieu de Paris, 1 Place du Parvis Notre Dame, 75004 Paris, France
    Ophthalmology 109:793-7. 2002
    To determine whether the mutational pattern of BIGH3-linked corneal dystrophies (CDs) can accurately predict the clinical course of the disease and be helpful in planning adequate surgical treatment.
  48. ncbi BIGH3 mutation spectrum in corneal dystrophies
    Francis L Munier
    Hopital Jules Gonin, Department of Ophthalmology, Lausanne, Switzerland
    Invest Ophthalmol Vis Sci 43:949-54. 2002
    To investigate the molecular pathology underlying BIGH3-related corneal dystrophies (CDs) and to further delineate genotype-phenotype specificity.
  49. ncbi Molecular properties of wild-type and mutant betaIG-H3 proteins
    Jung Eun Kim
    Department of Biochemistry, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Taegu, 700 422 Korea
    Invest Ophthalmol Vis Sci 43:656-61. 2002
    ..To understand the mechanisms of protein deposits in 5q31-linked corneal dystrophies, the molecular properties of betaIG-H3 and the effects of mutation on these properties were studied in vitro...
  50. ncbi Two mutations in the TGFBI (BIGH3) gene associated with lattice corneal dystrophy in an extensively studied family
    Gordon K Klintworth
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 45:1382-8. 2004
    ..To determine the genetic basis for lattice corneal dystrophy (LCD) in an extensively studied family...
  51. ncbi A novel nonsense mutation with a compound heterozygous mutation in TGFBI gene in lattice corneal dystrophy type I
    Tohru Sakimoto
    Department of Ophthalmology, Nihon University, School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 47:13-7. 2003
    We examined transforming growth factor beta-induced (TGFBI) gene mutations in a family with lattice corneal dystrophy type I.
  52. ncbi Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM
    Mark Aitkenhead
    Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697, USA
    Microvasc Res 63:159-71. 2002
    ..These data expand the suite of genes implicated in vascular remodeling and angiogenesis...
  53. ncbi cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta
    J Skonier
    Bristol Myers Squibb, Seattle, WA 98121
    DNA Cell Biol 11:511-22. 1992
    ..Since beta ig-h3 is induced in several cell lines whose proliferation is affected by TGF-beta 1, it may be involved in mediating some of the signals of this multifunctional growth modulator...
  54. ncbi A novel phenotype-genotype relationship with a TGFBI exon 14 mutation in a pedigree with a unique corneal dystrophy of Bowman's layer
    Catherine E Wheeldon
    Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Mol Vis 14:1503-12. 2008
    ..CDB) belongs to a group of dystrophies associated with mutations in the transforming growth factor-beta-induced (TGFBI) gene...
  55. ncbi Anticipation in familial lattice corneal dystrophy type I with R124C mutation in the TGFBI (BIGH3) gene
    Pablo Romero
    Depto de Oftalmologia, Hospital Clínico José Joaquín Aguirre, Universidad de Chile, Santiago, Chile
    Mol Vis 14:829-35. 2008
    ..To report the clinical, ophthalmic, and genetic characteristics for lattice corneal dystrophy type I (LCDI) in a Chilean family...
  56. ncbi Two distinct kerato-epithelin mutations in Reis-Bücklers corneal dystrophy
    M Okada
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Ophthalmol 126:535-42. 1998
    ..To see whether there was a genetic basis for these phenotypic variations, we analyzed beta ig-h3, the gene that codes for kerato-epithelin and that contains a mutation (Arg555Gln) that causes RBCD...
  57. ncbi A kerato-epithelin (betaig-h3) mutation in lattice corneal dystrophy type IIIA
    S Yamamoto
    Am J Hum Genet 62:719-22. 1998
  58. ncbi Mutation hot spots in 5q31-linked corneal dystrophies
    E Korvatska
    Unit of Molecular Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Am J Hum Genet 62:320-4. 1998
    Mutations in the BIGH3 gene on chromosome 5q31 cause four distinct autosomal dominant diseases of the human cornea: granular (Groenouw type I), Reis-Bücklers, lattice type I, and Avellino corneal dystrophies...
  59. ncbi A novel mutation I522N within the TGFBI gene caused lattice corneal dystrophy I
    Chunmei Zhang
    Department of Ophthalmology, Harbin Medical University The 2nd Affiliated Hospital, Harbin, China
    Mol Vis 15:2498-502. 2009
    To identify mutations within the TGFBI gene in a Chinese family with lattice corneal dystrophy type I (LCD I).
  60. ncbi Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen
    K Hashimoto
    Department of Removal Prosthodontics, School of Dentistry, Hiroshima University, Japan
    Biochim Biophys Acta 1355:303-14. 1997
    ..Since RGD-CAP transcripts were found in most tissues, this novel collagen-binding protein may play an important role in cell-collagen interactions in various tissues including developing cartilage...
  61. ncbi Kerato-epithelin mutations in four 5q31-linked corneal dystrophies
    F L Munier
    Unit of Molecular Genetics, CHUV, Lausanne, Switzerland
    Nat Genet 15:247-51. 1997
    Granular dystrophy Groenouw type I (CDGG1), Reis-Bücklers (CDRB), lattice type I (CDL1) and Avellino (ACD) are four 5q31-linked human autosomal dominant corneal dystrophies...
  62. ncbi Novel and known mutations of TGFBI, their genotype-phenotype correlation and structural modeling in 3 Chinese families with lattice corneal dystrophy
    Xingwu Zhong
    Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, P R China
    Mol Vis 16:224-30. 2010
    To report novel transforming growth factor beta-induced (TGFBI) mutations responsible for lattice corneal dystrophy (LCD), the associated genotype-phenotype correlation, and structural changes in the mutant proteins in three Chinese ..
  63. ncbi Three autosomal dominant corneal dystrophies map to chromosome 5q
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City 52242
    Nat Genet 6:47-51. 1994
    ..The maximum combined lod score using all 114 affected patients was 28.6 with marker D5S393. None of the 14 known human amyloid-associated genes map to chromosome 5...
  64. ncbi cDNA from human ocular ciliary epithelium homologous to beta ig-h3 is preferentially expressed as an extracellular protein in the corneal epithelium
    J Escribano
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510
    J Cell Physiol 160:511-21. 1994
    ....
  65. ncbi beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice
    J Skonier
    Bristol Myers Squibb, Pharmaceutical Research Institute Seattle, WA 98121
    DNA Cell Biol 13:571-84. 1994
    ..The corresponding mouse beta ig-h3 gene was mapped to mouse chromosome 13 region B to C1, which confirms a region of conservation on human chromosome 5 and mouse chromosome 13. We suggest that this protein be named p68 beta ig-h3...
  66. ncbi Heterogeneity in granular corneal dystrophy: identification of three causative mutations in the TGFBI (BIGH3) gene-lessons for corneal amyloidogenesis
    H S Stewart
    Department of Medical Genetics and Regional Genetics Service, St Mary s Hospital, Manchester, UK
    Hum Mutat 14:126-32. 1999
    Six autosomal dominant corneal dystrophies are caused by mutations in the TGFBI (BIGH3) gene on chromosome 5q31: three types of lattice corneal dystrophy (LCD), including type I and type IIIA, granular, Avellino (ACD), and Reis-Bucklers...
  67. ncbi An atypical phenotype of Reis-Bücklers corneal dystrophy caused by the G623D mutation in TGFBI
    Dandan Li
    Department of Ophthalmology, Harbin Medical University The 2nd Affiliated Hospital, Harbin, China
    Mol Vis 14:1298-302. 2008
    To characterize the molecular defects in the TGFBI gene in a Chinese family with an unusual phenotype of Reis-Bücklers corneal dystrophy (RBCD).
  68. ncbi Association of autosomal dominantly inherited corneal dystrophies with BIGH3 gene mutations in Japan
    Y Mashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 130:516-7. 2000
    To evaluate the incidence of BIGH3 gene mutations in 164 unrelated Japanese patients with corneal stromal dystrophies with an autosomal dominant trait.
  69. ncbi Lattice corneal dystrophy type III in patients with a homozygous L527R mutation in the TGFBI gene
    Tomoyo Funayama
    Jpn J Ophthalmol 50:62-4. 2006
  70. ncbi A subset of patients with epithelial basement membrane corneal dystrophy have mutations in TGFBI/BIGH3
    Sandrine Boutboul
    Centre de Recherche Thérapeutique en Ophtalmologie CERTO, Faculté Necker Enfants Malades, Paris, France
    Hum Mutat 27:553-7. 2006
    ..as well as the analysis of single affected individuals; we identified two different point mutations in the TGFBI/BIGH3 genes, genes known to be associated with other corneal dystrophies...
  71. ncbi [A research on TGFBI gene mutations in Chinese families with corneal dystrophies]
    Yan hua Qi
    Department of Ophthalmology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150086 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:310-2. 2006
    To identify what kind of TGFBI gene mutation happening to Chinese patients with corneal dystrophies.
  72. ncbi A novel H572R mutation in the transforming growth factor-beta-induced gene in a Thai family with lattice corneal dystrophy type I
    La ongsri Atchaneeyasakul
    Department of Ophthalmology, Siriraj Hospital Mahidol University, Bangkok, Thailand
    Jpn J Ophthalmol 50:403-8. 2006
    To describe a large Thai family with lattice corneal dystrophy (LCD) type I and to determine whether this LCD is associated with mutations within the transforming growth factor-beta-induced (TGFBI) gene.
  73. ncbi A novel variant lattice corneal dystrophy caused by association of mutation (V625D) in TGFBI gene
    Xin Tian
    Department of Ophthalmology, Third Hospital, Peking University, Beijing, China
    Am J Ophthalmol 144:473-5. 2007
    To characterize the molecular defect in the TGFBI gene in a Chinese family affected with an atypical lattice corneal dystrophy.
  74. ncbi The TGFBI A546D mutation causes an atypical type of lattice corneal dystrophy
    Vicente Correa-Gomez
    Research Unit, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico
    Mol Vis 13:1695-700. 2007
    To report the clinical, molecular, and histopathological features of a distinct transforming growth factor-beta-induced (TGFBI) gene-linked amyloidotic corneal dystrophy exhibiting an unusual lattice pattern.
  75. ncbi Spontaneous and inheritable R555Q mutation in the TGFBI/BIGH3 gene in two unrelated families exhibiting Bowman's layer corneal dystrophy
    Xinping C Zhao
    Department of Ophthalmology and Visual Science and Hermann Eye Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Ophthalmology 114:e39-46. 2007
    Bowman's layer corneal dystrophies (CDBs) include 2 distinct types: CDB1, or Reis-Bücklers (RBCD), and CDB2, or Thiel-Behnke (TBCD)...
  76. ncbi A novel variant of granular corneal dystrophy caused by association of 2 mutations in the TGFBI gene-R124L and DeltaT125-DeltaE126
    P Dighiero
    Laboratoire de Biochimie et Genetique Moleculaire, 123 boulevard du Port Royal, 75014 Paris, France
    Arch Ophthalmol 118:814-8. 2000
    To characterize the molecular defect in the TGFBI gene in a French family affected with an atypical granular corneal dystrophy.
  77. ncbi Corneal amyloidosis caused by Leu518Pro mutation of betaig-h3 gene
    K Hirano
    Department of Ophthalmology, Nagoya University School of Medicine, Aichi, Japan
    Br J Ophthalmol 84:583-5. 2000
    ..To report a Japanese family diagnosed clinically as having lattice corneal dystrophy type I (LCDI) in which a Leu518Pro mutation in the betaig-h3 gene and not the R124C mutation reported previously was found...
  78. ncbi Phenotype associated with the H626P mutation and other changes in the TGFBI gene in Czech families
    Petra Liskova
    Division of Molecular Genetics, Institute of Ophthalmology, UCL, London, UK
    Ophthalmic Res 40:105-8. 2008
    To evaluate mutations in the transforming-growth-factor-beta-induced (TGFBI) gene in patients of Czech origin with autosomal dominant corneal dystrophies.
  79. ncbi A common beta ig-h3 gene mutation (delta f540) in a large cohort of Sardinian Reis Bücklers corneal dystrophy patients. Mutations in brief no. 180. Online
    C Rozzo
    Istituto di Genetica Molecolare, C N R, Alghero, Italy
    Hum Mutat 12:215-6. 1998
    ..Recently RBCD, together with lattice corneal dystrophy type I (LCDI), granular corneal dystrophy (CDGG1) and Avellino stromal dystrophy (ASD), all mapped on 5q31, were found to be associated to four different mutations ..
  80. ncbi Cat scratch disease and acquired immunodeficiency disease: diagnosis by transmission electron microscopy
    J G Guccion
    Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Washington, DC, USA
    Ultrastruct Pathol 20:195-202. 1996
    ..The diagnosis of cat scratch disease (CSD) became apparent only after transmission electron microscopic study of the lymph node revealed clusters of small, ..
  81. ncbi [Serological cross-reaction among Bartonella henselae, Chlamydia pneumoniae and Coxiella burnetii by indirect fluorescence antibody method]
    H Tsuneoka
    Department of Clinical Laboratory, Yamaguchi-ken Kouseiren Nagato General Hospital
    Kansenshogaku Zasshi 75:406-10. 2001
    ..burnetii by indirect fluorescence antibody (IFA) method, using sera from 8 patients with cat scratch disease (CSD), 13 patients with C. pneumoniae infection and 12 patients with acute Q fever. B...
  82. ncbi Downregulation of human polymorphonuclear cell activities exerted by microorganisms belonging to the alpha-2 subgroup of Proteobacteria (Afipia felis and Rochalimaea henselae)
    D Fumarola
    Institutes of Medical Microbiology, General Pathology, University of Bari, Italy
    Immunopharmacol Immunotoxicol 16:449-61. 1994
    ..A. falis has been previously proposed as the causative agent of Cat Scratch Disease (CSD), but several recent lines of evidence attribute a major role to R. henselae...
  83. ncbi [A study on wounds caused by cats as basic materials of cat scratch disease]
    Y Arashima
    Department of Clinical Pathology, Nihon University School of Medicine
    Kansenshogaku Zasshi 68:734-9. 1994
    ..Their injuries clearly differed from those of the other groups. In our survey 33 cases were suspected to have CSD; 19 of 102 veterinarians, 4 of 45 veterinary technicians, 2 of 517 students of veterinary college, 1 of 400 ..
  84. ncbi [Bartonella henselae as a cause of optical nerve neuritis]
    Dragan Veselinović
    Klinicki centar, Klinika za ocne bolesti, Nis, Srbija
    Vojnosanit Pregl 63:971-4. 2006
    ..included into the group of gram-negative bacteria that can cause not so rare disease known as cat-scratch disease (CSD)...
  85. ncbi [Two patients with Bartonella henselae infection from a dog]
    I Murano
    Department of Pediatrics, Yamaguchi Prefectural Central Hospital
    Kansenshogaku Zasshi 75:808-11. 2001
    ..Careful review of suspected CSD victims' history of contact with animals is important in making a prompt diagnosis of B. henselae infection.
  86. ncbi Cervical lymphadenitis and cat scratch disease (CSD): an overlooked disease?
    P Rombaux
    Department of Otolaryngology Head and Neck Surgery, Universite Catholique de Louvain, Saint Luc University Hospital, Brussels, Belgium
    Acta Otorhinolaryngol Belg 54:491-6. 2000
    Cat Scratch Disease (CSD) is a benign disease characterized by regional lymphadenopathy affecting most frequently the head and neck region in children and young adults...
  87. ncbi [Cardiovascular impact of end-stage renal insufficiency in children undergoing hemodialysis]
    Y Aggoun
    , , Paris
    Arch Mal Coeur Vaiss 93:1009-13. 2000
    ..the wall (intima-media thickness, IMT), the cross sectional compliance (CSC), the cross sectional distensibility (CSD) and the (Einc) were determined. CSC and CSD were evaluated at the same level of pressure...
  88. ncbi [Early recurrence of Groenouw type I corneal dystrophy after phototherapeutic keratectomy. Molecular biology study suggests epithelial genesis]
    F Chiambaretta
    Service d Ophtalmologie, Hopital Gabriel Montpied, BP 69, Clermont Ferrand Cedex, France
    J Fr Ophtalmol 27:449-56. 2004
    ..corneal dystrophy Groenouw type 1 (GGI) is a rare autosomal dominant disease caused by allelic mutations of the BIGH3 gene...
  89. ncbi [Determination of anti-Bartonella henselae antibody by indirect fluorescence antibody test--comparison of two types of antigen: non-cocultivated B. henselae and cocultivated B. henselae with Vero cells]
    H Tsuneoka
    Department of Clinical Laboratory, Yamaguchi-ken Kouseiren Nagato General Hospital
    Kansenshogaku Zasshi 72:801-7. 1998
    Serum anti-Bartonella henselae IgG and IgM antibody titers for the diagnosis of cat scratch disease (CSD) were determined by indirect fluorescence antibody (IFA) tests. B...
  90. ncbi Seroprevalence of antibodies to Bartonella henselae in patients with cat scratch disease and in healthy controls: evaluation and comparison of two commercial serological tests
    A Sander
    Abteilung Mikrobiologie und Hygiene, Institut fur Medizinische Mikrobiologie und Hygiene, Klinikum der Universität Freiburg, Germany
    Clin Diagn Lab Immunol 5:486-90. 1998
    ..is a widely accepted diagnostic procedure for laboratory confirmation of the diagnosis of cat scratch disease (CSD). In this study a commercially available indirect immunofluorescence assay (IFA) based on B...
  91. ncbi [Clinical evaluation of commercial serological test for Bartonella infection]
    H Tsuneoka
    Department of Clinical Laboratory, Yamaguchi-ken Kouseiren Nagato General Hospital
    Kansenshogaku Zasshi 74:387-91. 2000
    ..henselae was negative in all individuals. Serological diagnosis of cat scratch disease (CSD) using indirect fluorescence antibody (IFA) methods (in-house and diagnostic kit) was made in either elevated ..
  92. ncbi Etiology of three recent diseases of citrus in São Paulo State: sudden death, variegated chlorosis and huanglongbing
    Joseph Marie Bové
    UMR Génomique, Développement et Pouvoir Pathogène, Laboratoire de Biologie Cellulaire et Moleculaire, IBVM, Université Victor Ségalen Bordeaux 2 et INRA, Centre INRA de Bordeaux, Villenave d Ornon Cedex, France
    IUBMB Life 59:346-54. 2007
    ..The new disease, citrus sudden death (CSD), resembles T-QD in several aspects...
  93. ncbi Characterization of Bartonella clarridgeiae flagellin (FlaA) and detection of antiflagellin antibodies in patients with lymphadenopathy
    A Sander
    Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Clin Microbiol 38:2943-8. 2000
    Cat scratch disease (CSD) is a frequent clinical outcome of Bartonella henselae infection in humans. Recently, two case reports indicated Bartonella clarridgeiae as an additional causative agent of CSD...
  94. ncbi [Longitudinal study of serological response to Bartonella henselae by indirect fluorescence assay in cat scratch disease]
    N Kusaba
    Department of Medicine, Yame General Hospital
    Kansenshogaku Zasshi 75:557-61. 2001
    ..IgG and IgM titers to Bartonella henselae were evaluated by an indirect fluorescence assay (IFA) in patients with CSD. The IFA test for the detection of IgG and IgM antibodies to B. henselae in 52 CSD patients showed that 40 (76...
  95. ncbi Synaptic connections of the cuticular stress detectors in crayfish: mono- and polysynaptic reflexes and the entrainment of fictive locomotion in an in vitro preparation
    C S Leibrock
    Institute of Biomedical and Life Sciences, University of Glasgow, Scotland, UK
    J Comp Physiol A 178:711-25. 1996
    The reflex connections made by Cuticular Stress Detector afferents (CSD1 and CSD2) with motorneurones of the four proximal muscle groups in the 5th walking legs of crayfish (Procambarus clarkii, Pacifastacus leniusculus) have been studied ..
  96. ncbi [Evaluation of serological response to Bartonella henselae by enzyme immunoassay in cat scratch disease]
    H Yoshida
    Department of Medicine, Yame General Hospital
    Kansenshogaku Zasshi 74:563-6. 2000
    ..The EIA test for detection of IgG and IgM antibodies to B. henselae concerning CSD showed that 8 (40%) of 20 patients with CSD had a serum IgG antibody titer of 12 EIA unit or more and that 5 (25%) ..
  97. ncbi Inhibitory activities of sulfated proteoglycans on chondroitin sulfate A-mediated cytoadherence of Plasmodium falciparum isolates from Thailand
    Sujittra Chaisavaneeyakorn
    Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 70:149-57. 2004
    ..decrease in PE adhesion to immobilized CSA and CSA-expressed cells was achieved with soluble chondroitin sulfate D (CSD) and chondroitin sulfate E (CSE) at low concentrations...
  98. ncbi Detection of antibodies to Bartonella henselae in clinically diagnosed cat scratch disease
    J P Flexman
    Department of Clinical Microbiology and Infectious Diseases, Royal Perth Hospital, WA
    Med J Aust 166:532-5. 1997
    To determine the usefulness of an indirect immunoflourescence antibody test for antibodies to Bartonella henselae in diagnosing cat scratch disease (CSD).
  99. ncbi Musculoskeletal manifestations of cat scratch disease
    Eran Maman
    Department of Pediatric Orthopaedics, Dana Children s Hospital
    Clin Infect Dis 45:1535-40. 2007
    Musculoskeletal manifestations (MMs) are considered to be rare in cat scratch disease (CSD) and are not well characterized. We aimed to study MMs of CSD.
  100. ncbi Serologic response to Bartonella henselae in patients with cat scratch disease and in sick and healthy children
    T Not
    Clinica Pediatrica and Istituto d Igiene, Trieste, Italy
    Acta Paediatr 88:284-9. 1999
    ..is the most reliable test for detecting antibody to Bartonella henselae in the diagnosis of cat scratch disease (CSD). Recently, an ELISA test has been proposed, but conflicting results are reported...

Research Grants67

  1. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    Jerome Engel; Fiscal Year: 2002
    ..In the course of these experiments we will utilize current source density (CSD) and voltage depth profile analysis, and single unit recording in both rats and patients...
  2. QUANTITATIVE ANALYSIS OF LEFT VENTRICULOPLASTY--CHF
    Mark Ratcliffe; Fiscal Year: 2009
    ..on akinetic infarcts), passive constraint device procedures such as the Acorn CorCapTM Cardiac Support Device (CSD), and cell transplantation are currently being performed...
  3. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2010
    b>bIGH3 (keratoepithelin) is a constituent of the extracellular matrix (ECM) responsible for cell adhesion...
  4. BIGH3 Wild-Type and Mutant Proteins
    GORDON KENNETH KLINTWORTH; Fiscal Year: 2010
    ..Mutations in the TGFBI (BIGH3) gene are responsible for several phenotypically different inherited corneal diseases that have no apparent non-..
  5. Mechanism of Medication Overuse Headache and Chronic Migraine Pain
    Frank Porreca; Fiscal Year: 2010
    ..unknown, an important theory suggests that migraine may occur as a consequence of cortical spreading depression (CSD)...
  6. MIGRAINE DRUG PROPHYLAXIS
    Michael Moskowitz; Fiscal Year: 2007
    ..that chronic daily administration of each drug suppressed the susceptibility to cortical spreading depression (CSD), a poorly understood, slowly propagating electrophysiological event...
  7. Genetic Risk Factors for Visceral Leishmaniasis
    MARY EDYTHE contact WILSON; Fiscal Year: 2010
    ..Aims of this RO1 are: 1. To test the hypothesis that candidate genes (SLC11A1, IL4-LECT2/TGFBI, HLA) determine susceptibility to cVL and to asymptomatic infection (DTH+) using dense tag-SNPs, with sample sizes ..
  8. Surgery to Prevent Postinfarction Ventricular Remodeling
    Robert Gorman; Fiscal Year: 2009
    ..therapeutic approaches to limit infarct expansion early after MI will be studied: heart wrapping with the Acorn CSD(R), infarct reperfusion and calcium hydroxyapatite microsphere gel injection...
  9. Surgery to Prevent Postinfarction Ventricular Remodeling
    Robert C Gorman; Fiscal Year: 2010
    ..therapeutic approaches to limit infarct expansion early after MI will be studied: heart wrapping with the Acorn CSD(R), infarct reperfusion and calcium hydroxyapatite microsphere gel injection...
  10. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 2001
    Cortical spreading depression (CSD) is a wave of depolarization that results in complex changes in pial arteriolar diameter, intense vasodilation lasting approximately 2 minutes, a return of diameter to baseline for several minutes, and ..
  11. QUANTITATIVE ANALYSIS OF LEFT VENTRICULOPLASTY--CHF
    Mark B Ratcliffe; Fiscal Year: 2010
    ..on akinetic infarcts), passive constraint device procedures such as the Acorn CorCapTM Cardiac Support Device (CSD), and cell transplantation are currently being performed...
  12. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2003
    ..high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid decarboxylase (CSD)...
  13. Migraine Pathophysiology and Treatment Mechanisms
    Michael Moskowitz; Fiscal Year: 2007
    ..Project 1 proposes to examine cortical spreading depression (CSD) in normal and genetically modified mice and expand upon a recent novel finding that prophylactic antimigraine ..
  14. Phase II Study of Imatinib Mesylate in Patients with Inoperable Melanoma
    Gary K Schwartz; Fiscal Year: 2010
    ..skin on the palms and soles (acral melanomas), on mucosal membranes, and from skin with chronic sun-induced damage (CSD) have distinctive patterns of chromosomal alterations as compared with the more common subtypes of melanoma arising ..
  15. Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine Models
    Cenk Ayata; Fiscal Year: 2010
    ..migraine expressing human mutations in implicated genes, as well as data implicating cortical spreading depression (CSD) in migraine aura...
  16. CRCNS: Integrated Empirical and Multiscale Modeling of Human Sleep Spindles
    Terrence J Sejnowski; Fiscal Year: 2010
    ..2) Analyze the recorded cortical Current Source Density (CSD) using Principal Components Analysis (PCA)...
  17. CRCNS: Integrated Empirical and Multiscale Modeling of Human Sleep Spindles
    Terrence Sejnowski; Fiscal Year: 2009
    ..2) Analyze the recorded cortical Current Source Density (CSD) using Principal Components Analysis (PCA)...
  18. Gene therapy in the cornea
    RAJIV MOHAN; Fiscal Year: 2007
    ..can be used to develop animal models for studying the specific function of disease-causing genes such as TGFp and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...
  19. Gene therapy in the cornea
    RAJIV MOHAN; Fiscal Year: 2007
    ..be used to develop animal models for studying the specific function of disease-causing genes such as TGF¿ and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...
  20. A Collaborative Study of Membranoproliferative Glomerulonephritis Type II
    Richard Smith; Fiscal Year: 2007
    ..can be documented in plasma by low APH 50 values, low Cs levels, and the appearance of the Cs degradation product Csd. Renal transplantation is associated with disease recurrence in virtually all allografts and a high percentage of ..
  21. A Collaborative Study of Membranoproliferative Glomerulonephritis Type II
    Richard Smith; Fiscal Year: 2009
    ..can be documented in plasma by low APH 50 values, low Cs levels, and the appearance of the Cs degradation product Csd. Renal transplantation is associated with disease recurrence in virtually all allografts and a high percentage of ..
  22. Gene therapy in the cornea
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2010
    ..can be used to develop animal models for studying the specific function of disease-causing genes such as TGF and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...
  23. A Collaborative Study of Membranoproliferative Glomerulonephritis Type II
    Richard J Smith; Fiscal Year: 2010
    ..can be documented in plasma by low APH 50 values, low Cs levels, and the appearance of the Cs degradation product Csd. Renal transplantation is associated with disease recurrence in virtually all allografts and a high percentage of ..
  24. Gene therapy in the cornea
    RAJIV MOHAN; Fiscal Year: 2009
    ..can be used to develop animal models for studying the specific function of disease-causing genes such as TGF and BIGH3 in the adult cornea in vivo without altering their expression in vital organs...