Gene Symbol: TGFB3
Description: transforming growth factor beta 3
Alias: ARVD, ARVD1, LDS5, RNHF, TGF-beta3, transforming growth factor beta-3, prepro-transforming growth factor beta-3
Species: human
Products:     TGFB3

Top Publications

  1. Cheifetz S, Bellon T, Calés C, Vera S, Bernabeu C, Massague J, et al. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem. 1992;267:19027-30 pubmed
    ..TGF-beta however is binding with high affinity to only a small fraction of the available endoglin molecules, suggesting that some rate-limiting event is required to sustain TGF-beta binding to endoglin. ..
  2. Saharinen J, Keski Oja J. Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. Mol Biol Cell. 2000;11:2691-704 pubmed
  3. Jugessur A, Lie R, Wilcox A, Murray J, Taylor J, Saugstad O, et al. Variants of developmental genes (TGFA, TGFB3, and MSX1) and their associations with orofacial clefts: a case-parent triad analysis. Genet Epidemiol. 2003;24:230-9 pubmed
    ..from a population-based study of orofacial clefts in Norway, and examined variants of developmental genes TGFA, TGFB3, and MSX1 in the etiology of orofacial clefts...
  4. Strzalka B, Dorecka M, Stanik Walentek A, Kowalczyk M, Kapral M, Romaniuk W, et al. Quantitative analysis of transforming growth factor beta isoforms mRNA in the human corneal epithelium. Folia Biol (Praha). 2008;54:46-52 pubmed
    ..We found different expression of the TGF-beta1, -2 and -3 isoforms in the human corneal epithelium. Such differential expression of TGF-betas suggests that each of them may play a specific role in corneal tissue. ..
  5. Kaartinen V, Voncken J, Shuler C, Warburton D, Bu D, Heisterkamp N, et al. Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet. 1995;11:415-21 pubmed
    ..This study demonstrates an essential function for TGF-beta 3 in the normal morphogenesis of palate and lung, and directly implicates this cytokine in mechanisms of epithelial-mesenchymal interaction. ..
  6. Mittl P, Priestle J, Cox D, McMaster G, Cerletti N, Grutter M. The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding. Protein Sci. 1996;5:1261-71 pubmed
    ..This dioxane may occupy a carbohydrate-binding site, because dioxane possesses some structural similarity with a carbohydrate. The dioxane is in contact with two tryptophans, which are often involved in carbohydrate recognition. ..
  7. Hering S, Isken F, Janott J, Jost C, Pommer A, Muhr G, et al. Analysis of TGFbeta3 gene expression and protein levels in human bone and serum. Exp Clin Endocrinol Diabetes. 2001;109:107-15 pubmed
    ..The high correlation of TGFbeta3 with IGF-I suggests parallel systemic principles of regulation. ..
  8. Vieira A, Orioli I, Castilla E, Cooper M, Marazita M, Murray J. MSX1 and TGFB3 contribute to clefting in South America. J Dent Res. 2003;82:289-92 pubmed
    MSX1 and TGFB3 have been proposed as genes in which mutations may contribute to non-syndromic forms of oral clefts; however, an interaction between these genes has not been described...
  9. Kim M, Kim H, Choi J, Nahm D. Transforming growth factor-beta3 gene SfaN1 polymorphism in Korean nonsyndromic cleft lip and palate patients. J Biochem Mol Biol. 2003;36:533-7 pubmed
    ..001), but not in females. In conclusion, the polymorphism of the SfaN1 site in TGF-beta3 was significantly different between the NSCL/P patients and the control. This may be a good screening marker for NSCL/P patients among Koreans. ..

More Information

Publications140 found, 100 shown here

  1. Gonzalez Fernandez T, Sathy B, Hobbs C, Cunniffe G, McCarthy H, Dunne N, et al. Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector. Acta Biomater. 2017;55:226-238 pubmed publisher
    ..When therapeutic genes encoding for transforming growth factor beta 3 (TGF-?3) and/or bone morphogenic protein 2 (BMP2) were delivered to MSCs, nHA promoted osteogenesis ..
  2. Gullard A, Croney C, Wu X, Mamaeva O, Sohn P, Cao X, et al. Reduced Dentin Matrix Protein Expression in Camurati-Engelmann Disease Transgenic Mouse Model. J Cell Physiol. 2016;231:1106-13 pubmed publisher
    ..indicated significant fold changes in the expression of Alpl, Bmp2-5, Col-1, -2, -4, and -6, Fgf, Mmp, Runx2, Tgfb3, Tfgbr3, and Vdr genes...
  3. Peng H, Yi Y, Zhou S, Xie S, Zhang G. Thalidomide Effects in Patients with Hereditary Hemorrhagic Telangiectasia During Therapeutic Treatment and in Fli-EGFP Transgenic Zebrafish Model. Chin Med J (Engl). 2015;128:3050-4 pubmed publisher
    ..from patient's peripheral blood mononuclear cells and plasma were used to detect the expression of transforming growth factor beta 3 (TGF-β3) messenger RNA (mRNA) and vascular endothelial growth factor (VEGF) protein before and ..
  4. Zhao X, Hwang N, Bichara D, Saris D, Malda J, Vacanti J, et al. Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction. J Tissue Eng Regen Med. 2017;11:2763-2773 pubmed publisher
    ..Efficient chondrogenic differentiation of BMSCs could provide a promising alternative cell population for auricular regeneration. Copyright © 2016 John Wiley & Sons, Ltd. ..
  5. Rottgers S, Gallo P, Gilbert J, MacIsaac Z, Cray J, Smith D, et al. Application of Laser Capture Microdissection to Craniofacial Biology: Characterization of Anatomically Relevant Gene Expression in Normal and Craniosynostotic Rabbit Sutures. Cleft Palate Craniofac J. 2017;54:109-118 pubmed publisher
    ..2 (FGF2), Fibroblast Growth Factor Receptor 2 (FGFR2), Transforming Growth Factor Beta 2 (TGF?-2), Transforming Growth Factor Beta 3 (TGF?-3), Bone Morphogenetic Protein 2 (BMP-2), Bone Morphogenetic Protein 4 (BMP-4), and Noggin ..
  6. He X, Sun Z, Manthari R, Wu P, Wang J. Fluoride altered rat's blood testis barrier by affecting the F-actin via IL-1α. Chemosphere. 2018;211:826-833 pubmed publisher
  7. Mo M, Okamoto J, Chen Z, Hirata T, Mikami I, Bosco Clément G, et al. Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma. PLoS ONE. 2013;8:e71816 pubmed publisher
    ..and migration, and downregulated a number of genes involved in proliferation and metastasis such as S100P, TGFB3, GINS3 and BAG1...
  8. Chen H, Yang J, Zhang S, Qin X, Jin W, Sun L, et al. Serological cytokine profiles of cardiac rejection and lung infection after heart transplantation in rats. J Cardiothorac Surg. 2019;14:26 pubmed publisher
    ..Such disease associated cytokine portraits might have the potential for early discrimination diagnosis. ..
  9. Hujiahemaiti M, Sun X, Zhou J, Lv H, Li X, Qi M, et al. Effects of quercetin on human oral keratinocytes during re-epithelialization: An in vitro study. Arch Oral Biol. 2018;95:187-194 pubmed publisher
    ..Integrin-α6, Integrin-β4), and growth factors (transforming growth factor beta 1,TGF-β1 and transforming growth factor beta 3, TGF-β3) were estimated using RT-qPCR...
  10. Kerola A, Lohi J, Heikkila P, Mutanen A, Jalanko H, Pakarinen M. Divergent expression of liver transforming growth factor superfamily cytokines after successful portoenterostomy in biliary atresia. Surgery. 2019;: pubmed publisher
    ..Respective gene expression (TGFB1, TGFB2, TGFB3, CTGF, DCN) was analyzed at follow-up using quantitative reverse transcription polymerase chain reaction (qRT-PCR)...
  11. Feng L, Jayes F, Johnson L, Schomberg D, Leppert P. Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin. Curr Protein Pept Sci. 2017;18:155-166 pubmed publisher
    ..Applying the same insult supplemented with TGFB3 (1-10ng/ml) and ascorbic acid (100?g/ml) in the serum add-back treatment, we further demonstrated that cells ..
  12. Martín Peña A, Porter R, Plumton G, McCarrel T, Morton A, Guijarro M, et al. Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations. Eur Cell Mater. 2018;36:156-170 pubmed publisher
    ..In 3D cultures of MSC aggregates and polyethylene glycol-hyaluronic acid (PEG-HA) hydrogels, transforming growth factor beta 3 (TGF-β3)-mediated chondroinduction increased Col2 reporter activity, demonstrating close ..
  13. Lee M, Ahmad T, Lee J, Awada H, Wang Y, Kim K, et al. Dual delivery of growth factors with coacervate-coated poly(lactic-co-glycolic acid) nanofiber improves neovascularization in a mouse skin flap model. Biomaterials. 2017;124:65-77 pubmed publisher
    ..e., vascular endothelial growth factor (VEGF) and/or transforming growth factor beta 3 (TGF-?3))...
  14. Portocarrero Huang G, Menezes R, Vincent R, Hammond W, Rizio L, Collins G, et al. * Gelatin Scaffolds Containing Partially Sulfated Cellulose Promote Mesenchymal Stem Cell Chondrogenesis. Tissue Eng Part A. 2017;23:1011-1021 pubmed publisher
    ..These studies demonstrated the potential of pSC sulfate as a scaffolding material for cartilage tissue engineering. ..
  15. Deb D, Bao R, Li Y. Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activation of fibrogenic program in the kidney. FASEB J. 2017;31:2065-2075 pubmed publisher
    ..hyperacetylation in approximately 5000 gene promoters in glomerular mesangial cells, including those of Tgfb1, Tgfb3, and Ctgf, the major profibrotic factors that are known to drive diabetic renal fibrogenesis...
  16. Wu X, Ruan L, Yang Y, Mei Q. Analysis of gene expression changes associated with human carcinoma-associated fibroblasts in non-small cell lung carcinoma. Biol Res. 2017;50:6 pubmed publisher
    ..Multiple genes including bone morphogenetic protein 4 (BMP4) and transforming growth factor, beta 3 (TGFB3) are involved in the TGF-? signaling pathway...
  17. Proietti R, Russo V, Alturki A. Anti-arrhythmic therapy in patients with non-ischemic cardiomyopathy. Pharmacol Res. 2019;143:27-32 pubmed publisher
    ..Evidence for AAD therapy for arrhythmogenic right ventricular dysplasia (ARVD) is limited by its low prevalence and lack of studies...
  18. Li C, Zhang X, Péault B, Jiang J, Ting K, Soo C, et al. Accelerated Chondrogenic Differentiation of Human Perivascular Stem Cells with NELL-1. Tissue Eng Part A. 2016;22:272-85 pubmed publisher
    ..Furthermore, the addition of NELL-1 to a transforming growth factor beta 3 (TGF-β3) + bone morphogenetic protein-6 (BMP-6) "cocktail" resulted in the best combinatorial ..
  19. Wei S, Fu X, Liang X, Zhu M, Jiang Z, Parish S, et al. Enhanced mitogenesis in stromal vascular cells derived from subcutaneous adipose tissue of Wagyu compared with those of Angus cattle. J Anim Sci. 2015;93:1015-24 pubmed publisher
    ..Expression of transforming growth factor β 3 (TGFB3) and bone morphogenetic protein 2 (BMP2) in Wagyu SV cells was lower than that of Angus, providing potential clues ..
  20. Tay L, Wiraja C, Wu Y, Yang Z, Lee E, Xu C. The effect of temporal manipulation of TGF?3 and FGF2 on the derivation of proliferative chondrocytes from Mensenchymal Stem Cells - a study monitored by qRT-PCR and Molecular Beacon based Nanosensors. J Biomed Mater Res A. 2017;: pubmed publisher
    ..The temporal effect of transforming growth factor beta 3 (TGF?3) and fibroblast growth factor 2 (FGF2) on the derivation of proliferative chondrocytes from ..
  21. Focardi M, Cameli M, Carbone S, Massoni A, De Vito R, Lisi M, et al. Traditional and innovative echocardiographic parameters for the analysis of right ventricular performance in comparison with cardiac magnetic resonance. Eur Heart J Cardiovasc Imaging. 2015;16:47-52 pubmed publisher
    ..idiopathic dilated cardiomyopathy, 10 hypertrophic cardiomyopathy, 10 arrhythmogenic right ventricular dysplasia (ARVD), 5 infiltrative cardiomyopathy, and 9 other reasons. RVEF was measured by magnetic resonance imaging (MRI)...
  22. Nazempour A, Quisenberry C, Van Wie B, Abu Lail N. Nanomechanics of Engineered Articular Cartilage: Synergistic Influences of Transforming Growth Factor-β3 and Oscillating Pressure. J Nanosci Nanotechnol. 2016;16:3136-3145 pubmed a unique centrifugal bioreactor under oscillating hydrostatic pressure (OHP) and supply of transforming growth factor beta 3 (TGF-β3) that mimic in vivo environments...
  23. Tao Y, Zhou X, Liang C, Li H, Han B, Li F, et al. TGF-β3 and IGF-1 synergy ameliorates nucleus pulposus mesenchymal stem cell differentiation towards the nucleus pulposus cell type through MAPK/ERK signaling. Growth Factors. 2015;33:326-36 pubmed publisher
    This study aimed to investigate the synergy between transforming growth factor beta 3 (TGF-β3) and insulin-like growth factor 1 (IGF-1) on nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) and the underlying mechanism using a ..
  24. Hirayama H, Koyama K, Sawai K, Fujii T, Naito A, Fukuda S, et al. Localization of TGF-β and TGF-β receptor in bovine term placentome and expression differences between spontaneous and induced parturition. Placenta. 2015;36:1239-45 pubmed publisher
    ..TGFB1 is characteristically localized in the maternal septum in caruncle in contrast to TGFB2 and TGFB3, which are mainly found in cotyledonary villi and maternal epithelial cells. TGFBR1 and TGFBR2 colocalized in BNCs...
  25. Kim Y, Lee Y, Park J, Lee H, Cheon C, Kim S, et al. High diagnostic yield of clinically unidentifiable syndromic growth disorders by targeted exome sequencing. Clin Genet. 2017;92:594-605 pubmed publisher
    ..2%. One boy with overgrowth had a TGFB3 gene mutation...
  26. Rowland C, Glass K, Ettyreddy A, Gloss C, Matthews J, Huynh N, et al. Regulation of decellularized tissue remodeling via scaffold-mediated lentiviral delivery in anatomically-shaped osteochondral constructs. Biomaterials. 2018;177:161-175 pubmed publisher
  27. Lin E, Kuo P, Liu Y, Yang A, Tsai S. Transforming growth factor-? signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population. Sci Rep. 2017;7:13589 pubmed publisher
    ..genes of SMAD family member 2 (SMAD2), SMAD3, SMAD4, transforming growth factor beta 1 (TGFB1), TGFB2, TGFB3, transforming growth factor beta receptor 1 (TGFBR1), and TGFBR2 are associated with MetS and its individual ..
  28. Doraczynska Kowalik A, Nelke K, Pawlak W, Sasiadek M, Gerber H. Genetic Factors Involved in Mandibular Prognathism. J Craniofac Surg. 2017;28:e422-e431 pubmed publisher
    ..FGF23, FGFR2, TBX5, ALPL, HSPG2, EVC, EVC2, the HoxC gene cluster, insulin-like growth factor 1, PLXNA2, SSX2IP, TGFB3, LTBP2, MMP13/CLG3, KRT7, and FBN3...
  29. Tavano A, Maurel B, Gaubert J, Varoquaux A, Cassagneau P, Vidal V, et al. MR imaging of arrhythmogenic right ventricular dysplasia: What the radiologist needs to know. Diagn Interv Imaging. 2015;96:449-60 pubmed publisher
    Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited heart muscle disease that predominantly affects the right ventricle...
  30. Toraih E, Ibrahiem A, Fawzy M, Hussein M, Al Qahtani S, Shaalan A. MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma. Oxid Med Cell Longev. 2017;2017:3269379 pubmed publisher
    ..i>TP53INP2 and DFFA); cell proliferation (E2F3); and cell differentiation (SOX2 and TGFB3) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been ..
  31. Angel P, Narmoneva D, Sewell Loftin M, Munjal C, Dupuis L, Landis B, et al. Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease. Ann Biomed Eng. 2017;45:2548-2562 pubmed publisher marked depletion of extracellular matrix (ECM) proteins interacting with TGFB1, including latent transforming growth factor beta 3 (LTBP3), fibulin 5 (FBLN5), and cartilage intermediate layer protein 1 (CILP1)...
  32. Isselbacher E, Lino Cardenas C, Lindsay M. Hereditary Influence in Thoracic Aortic Aneurysm and Dissection. Circulation. 2016;133:2516-28 pubmed publisher
    ..various components of the transforming growth factor beta (TGF-?) signaling cascade (FBN1, TGFBR1, TGFBR2, TGFB2, TGFB3, SMAD2, SMAD3 and SKI), and these conditions are known collectively as the TGF-? vasculopathies...
  33. Lepage S, Nagy K, Sung H, Kandel R, Nagy A, Koch T. Generation, Characterization, and Multilineage Potency of Mesenchymal-Like Progenitors Derived from Equine Induced Pluripotent Stem Cells. Stem Cells Dev. 2016;25:80-9 pubmed publisher
    ..We demonstrate a protocol for the derivation of MSC-like progenitor populations from equine iPS cells. ..
  34. Brunskill E, Potter S. Pathogenic pathways are activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis. BMC Nephrol. 2015;16:71 pubmed publisher
    ..The mesangial cells showed increased expression of profibrotic factors, including thrombospondin, Tgfb2 and Tgfb3, as well as the angiogenesis factor Vegf...
  35. Lane J, Yumoto K, Azhar M, Ninomiya Tsuji J, Inagaki M, Hu Y, et al. Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development. Dev Biol. 2015;398:231-41 pubmed publisher
    ..anterior and posterior secondary palate, these phenotypes were less severe than those seen in the corresponding Tgfb3 mutants...
  36. Kanda M, Shimizu D, Fujii T, Tanaka H, Shibata M, Iwata N, et al. Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer. Int J Oncol. 2016;49:1195-202 pubmed publisher
    ..Differential expression of PRMT5 mRNA by GC cell lines correlated positively with the levels of GEMIN2, STAT3 and TGFB3. PRMT5 knockdown reduced the proliferation, invasion and migration of a GC cell line...
  37. Zhu J, Chen C, Yang B, Guo Y, Ai H, Ren J, et al. A systems genetics study of swine illustrates mechanisms underlying human phenotypic traits. BMC Genomics. 2015;16:88 pubmed publisher
    ..By leveraging a human protein-protein interaction network, we identified two putative candidate causal genes TGFB3 and DAB2IP and the known regulators MESP1 and MESP2 as responsible for the variation in rib number and identified ..
  38. Lin H, Moustakas A, Knaus P, Wells R, Henis Y, Lodish H. The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands. J Biol Chem. 1995;270:2747-54 pubmed
    ..Thus, the type III receptor or some other component is required for transmission of TGF-beta 2-induced signals by the type II receptor. ..
  39. Chen Y, Dabovic B, Annes J, Rifkin D. Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS Lett. 2002;517:277-80 pubmed
    ..The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-beta propeptide. ..
  40. Nasu K, Nishida M, Matsumoto H, Bing S, Inoue C, Kawano Y, et al. Regulation of proliferation, motility, and contractivity of cultured human endometrial stromal cells by transforming growth factor-beta isoforms. Fertil Steril. 2005;84 Suppl 2:1114-23 pubmed
    ..Transforming growth factor-beta may be involved in the protection of the endometrium from extensive fibrosis and scarring by regulating ESC function during the perimenstrual period. ..
  41. Lam S, Wiercinska E, Teunisse A, Lodder K, Ten Dijke P, Jochemsen A. Wild-type p53 inhibits pro-invasive properties of TGF-β3 in breast cancer, in part through regulation of EPHB2, a new TGF-β target gene. Breast Cancer Res Treat. 2014;148:7-18 pubmed publisher
    ..The results show an intricate interplay between p53 and TGF-β3 whereby p53 inhibits the TGF-β3-induced expression of genes, e.g., EPHB2, to impede tumor cell invasion and migration. ..
  42. Bandyopadhyay D, Sahoo D, Zein J, Brunken R, Tchou P, Culver D. Outcome of cardiac sarcoidosis after radiofrequency ablation and placement of AICD- A propensity matched analysis. Sarcoidosis Vasc Diffuse Lung Dis. 2015;32:70-9 pubmed
    ..against those with only ICD placement and contemporaneous patients with arrhythmogenic right ventricular dysplasia (ARVD) who had RFA...
  43. Augoff K, Grabowski K, Rabczynski J, Kolondra A, Tabola R, Sikorski A. Expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity. Cancer Invest. 2009;27:443-52 pubmed publisher
    ..Therefore, the system of TGF-beta liberation from its complex with DCN by activated MMP-2 does not seem to contribute to esophageal cancerogenesis, although this hypothesis should be reevaluated with a larger study group. ..
  44. Dong X, Hudson N, Lu C, Springer T. Structural determinants of integrin β-subunit specificity for latent TGF-β. Nat Struct Mol Biol. 2014;21:1091-6 pubmed publisher
    ..Variation in a pair of single key residues in SDL1 and SDL3 correlates with the variation of the entire β subunit in integrin evolution, thus suggesting a paradigmatic role in overall β-subunit function. ..
  45. Gross J, Stahl B, Powers A, Carlson B. Natural bone fragmentation in the blind cave-dwelling fish, Astyanax mexicanus: candidate gene identification through integrative comparative genomics. Evol Dev. 2016;18:7-18 pubmed publisher
    ..screened coding sequence alterations in this region, identifying two key genes: transforming growth factor β3 (tgfb3) and bone morphogenetic protein 4 (bmp4)...
  46. Sawant A, Te Riele A, Tichnell C, Murray B, Bhonsale A, Tandri H, et al. Safety of American Heart Association-recommended minimum exercise for desmosomal mutation carriers. Heart Rhythm. 2016;13:199-207 pubmed publisher associated with adverse outcomes in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). Exercise recommendations for family members remain undetermined...
  47. DEAN M, Davis D, Burdette J. Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling. Cancer Lett. 2017;391:114-124 pubmed publisher
    ..were higher in serous tumors relative to the normal ovary, while inhibitors of activin A signaling (INHA and TGFB3) were lower...
  48. Zbucka Kretowska M, Charkiewicz K, Goscik J, Wolczynski S, Laudanski P. Maternal plasma angiogenic and inflammatory factor profiling in foetal Down syndrome. PLoS ONE. 2017;12:e0189762 pubmed publisher
    ..039), angiostatin (p = 0.0142), I-309 (p = 0.0476), TGFb3 (p = 0.0395), and VEGF-D (p = 0.0173)-compared to concentrations in patients with healthy foetuses...
  49. Hildebrand A, Romaris M, Rasmussen L, Heinegard D, Twardzik D, Border W, et al. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J. 1994;302 ( Pt 2):527-34 pubmed
    ..They may regulate TGF-beta activities by sequestering TGF-beta into extracellular matrix. ..
  50. Lourenço S, Uyekita S, Lima D, Soares F. Developing human minor salivary glands: morphological parallel relation between the expression of TGF-beta isoforms and cytoskeletal markers of glandular maturation. Virchows Arch. 2008;452:427-34 pubmed
    ..The data suggest that TGF-beta have a role to play in salivary gland development and differentiation...
  51. You H, Chen A, Liu T, Wang M, Zhang G. Construction of eukaryotic expression plasmid of hTGF-?3 and its inducing effect on differentiation of precartilaginous stem cells into chondroblasts. J Huazhong Univ Sci Technolog Med Sci. 2011;31:524 pubmed publisher
    ..1(+)-hTGF-?3-transfected cells. It was concluded that hTGF-?3 could be stably expressed in pcDNA3.1(+)-hTGF-?3-transfected PSCs and induce the differentiation of PSCs into chondroblasts. ..
  52. Walshe T, dela Paz N, D Amore P. The role of shear-induced transforming growth factor-? signaling in the endothelium. Arterioscler Thromb Vasc Biol. 2013;33:2608-17 pubmed publisher
    ..Shear stress of HUVECs induces TGF-?3 signaling and subsequent activation of Krüppel-like factor 2 and NO, and represents a novel role for TGF-?3 in the maintenance of HUVEC homeostasis in a hemodynamic environment. ..
  53. Meschiari C, Jung M, Iyer R, Yabluchanskiy A, Toba H, Garrett M, et al. Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing following myocardial infarction. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00453.2017 pubmed publisher
    ..vascular endothelial growth factor-A (VEGFA), platelet-derived growth factor subunit A (Pdgfa), and transforming growth factor beta 3 (Tgfb3) along with elevated tissue inhibitor of MMP-4 (Timp4) macrophage expression reveal ..
  54. Xiuying Wang -, Wensi Tang -, Hui Cui -, Shan Zeng -, Feng D, Fulham M. Multi-view collaborative segmentation for prostate MRI images. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:3529-3532 pubmed publisher
    ..MRI patient studies with respect to dice similarity coefficient (DSC), absolute relative volume difference (ARVD) and average symmetric surface distance (ASSD) (mm)...
  55. Ambros R, Kallakury B, Malfetano J, Mihm M. Cytokine, cell adhesion receptor, and tumor suppressor gene expression in vulvar squamous carcinoma: correlation with prominent fibromyxoid stromal response. Int J Gynecol Pathol. 1996;15:320-5 pubmed
    ..The current study demonstrates that alterations in cytokine and cell adhesion receptor status variably occur in vulvar squamous carcinoma and that such alterations may affect tumor morphology and behavior. ..
  56. Ilangovan U, Deep S, Hinck C, Hinck A. Sequential resonance assignments of the extracellular domain of the human TGFbeta type II receptor in complex with monomeric TGFbeta3. J Biomol NMR. 2004;29:103-4 pubmed
  57. Martínez Sanz E, Del Río A, Barrio C, Murillo J, Maldonado E, Garcillán B, et al. Alteration of medial-edge epithelium cell adhesion in two Tgf-beta3 null mouse strains. Differentiation. 2008;76:417-30 pubmed
    ..We thus provide insight into the molecular bases of this important process and the cleft palate presented by Tgf-beta3 null mutant mice...
  58. Joseph D, Malik M, Nurudeen S, Catherino W. Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor beta-3. Fertil Steril. 2010;93:1500-8 pubmed publisher
    ..65-fold) and -11 (0.68-fold). TGF-beta3 induced a molecular phenotype in myometrial cells that was similar to leiomyoma cells, with elevated production of ECM-related genes and decreased production of ECM degradation-related genes. ..
  59. Li Q, Li X, Zhang F, Chen F. The identification of a novel locus for mandibular prognathism in the Han Chinese population. J Dent Res. 2011;90:53-7 pubmed publisher
    ..57 to 84.66 Mb) between rs1468507 and rs7141857. Within this interval, the candidate functional genes are TGFB3 and LTBP2...
  60. Saleem S, Rajendran R, Moinak B, Anna J, Pramod B. Evidence for transforming growth factor-beta 3 gene polymorphism in non-syndromic cleft lip and palate patients from Indian sub-continent. Med Oral Patol Oral Cir Bucal. 2012;17:e197-200 pubmed
  61. Rienhoff H, Yeo C, Morissette R, Khrebtukova I, Melnick J, Luo S, et al. A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A. 2013;161A:2040-6 pubmed publisher
    ..A de novo mutation in TGFB3 was identified by exome sequencing...
  62. Patel P, Khan N, Rani M, Gupta D, Jameel S. The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-? that activates profibrogenic genes in hepatic stellate cells. PLoS ONE. 2014;9:e88934 pubmed publisher
    ..Besides its other roles in pathogenesis, Vpu is likely to contribute to hepatic fibrosis through this hitherto unknown mechanism. ..
  63. Orgeron G, Calkins H. Advances in the Diagnosis and Management of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Curr Cardiol Rep. 2016;18:53 pubmed publisher
    Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy characterized by ventricular arrhythmias, right ventricular dysfunction, and sudden cardiac death...
  64. Anis Munirah M, Lim W, Sharifah Ainon I. Arrythmogenic Right Ventricular Dysplasia. Med J Malaysia. 2016;71:357-359 pubmed
    A 10-year-old well and asymptomatic female was referred for screening of acute right ventricular dilatation (ARVD) as she had an elder brother diagnosed with ARVD whom died of sudden cardiac death...
  65. Nishida K, Sotozono C, Adachi W, Yamamoto S, Yokoi N, Kinoshita S. Transforming growth factor-beta 1, -beta 2 and -beta 3 mRNA expression in human cornea. Curr Eye Res. 1995;14:235-41 pubmed
  66. Lammerts E, Roswall P, Sundberg C, Gotwals P, Koteliansky V, Reed R, et al. Interference with TGF-beta1 and -beta3 in tumor stroma lowers tumor interstitial fluid pressure independently of growth in experimental carcinoma. Int J Cancer. 2002;102:453-62 pubmed
    ..First by controlling TIFP and by that potentially the uptake of anticancer drugs into tumors and second by their suggested role in maintaining a supportive tumor stroma. ..
  67. Yinon Y, Nevo O, Xu J, Many A, Rolfo A, Todros T, et al. Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3. Am J Pathol. 2008;172:77-85 pubmed
    ..These data demonstrate that oxygen regulates the placental expression of endoglin via TGF-beta 3. Reduced placental perfusion leading to placental hypoxia might contribute to the increased expression of endoglin in IUGR pregnancies. ..
  68. Yue B, Lin Y, Ma X, Xiang H, Qiu C, Zhang J, et al. Survivin-TGFB3-TIMP1 Gene Therapy Via Lentivirus Vector Slows the Course of Intervertebral Disc Degeneration in an In Vivo Rabbit Model. Spine (Phila Pa 1976). 2016;41:926-34 pubmed publisher
    The ability of lentivirus vector (LV) survivin-transforming growth factor beta 3 (TGFB3)-tissue inhibitor of metalloproteinases 1 (TIMP1) on slowing disc degeneration was evaluated by an animal experiment...
    ..The VC+Q10 group showed a low Bax/Bcl-xl ratio and a high expression of MAP3K12 and TGFB3 compared to the VC+...
  70. Müssigbrodt A, Bertagnolli L, Efimova E, Kosiuk J, Dinov B, Bode K, et al. Myocardial voltage ratio in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Herzschrittmacherther Elektrophysiol. 2017;28:219-224 pubmed publisher
    ..the endocardium and the epicardium in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). Electroanatomical mapping data were derived from our ARVD/C registry...
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    Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy mainly caused by desmosomal gene mutation...
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    ..Finally, the three TGF? isoforms showed distinct association patterns with patient outcome depending on the different molecular subtype, highlighting context-dependent, differential prognostic values. ..
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    ..By analogy to type beta 1 and type beta 2 transforming growth factors, we predict the protein to be synthesized as a 412 amino acid precursor that undergoes proteolytic cleavage to produce the mature polypeptide. ..
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    ..The results suggest that release of betaglycan into the medium converts this enhancer of TGF-beta action into a TGF-beta antagonist. ..
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  76. Li M, Qiu L, Hu W, Deng X, Xu H, Cao Y, et al. Genetically-modified bone mesenchymal stem cells with TGF-β3 improve wound healing and reduce scar tissue formation in a rabbit model. Exp Cell Res. 2018;367:24-29 pubmed publisher
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    ..The restoration of the expression of T?RII and T?RIII in oral cancerous tissues may represent a novel strategy for the treatment of oral carcinoma. ..
  78. Patel H, Shah P, Rampal U, Shamoon F, Tiyyagura S. Arrythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and cathecholaminergic polymorphic ventricular tachycardia (CPVT): A phenotypic spectrum seen in same patient. J Electrocardiol. 2015;48:874-8 pubmed publisher
    b>ARVD/C and CPVT are rare inheritable sudden cardiac death syndromes predominantly expressed in younger individuals...
  79. Müssigbrodt A, Efimova E, Knopp H, Bertagnolli L, Dagres N, Richter S, et al. Should all patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy undergo epicardial catheter ablation?. J Interv Card Electrophysiol. 2017;48:193-199 pubmed publisher the therapeutic option of choice in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and recurrent ventricular tachycardia (VT)...
  80. Toom A, Arend A, Gunnarsson D, Ulfsparre R, Suutre S, Haviko T, et al. Bone formation zones in heterotopic ossifications: histologic findings and increased expression of bone morphogenetic protein 2 and transforming growth factors beta2 and beta3. Calcif Tissue Int. 2007;80:259-67 pubmed
    ..Our data indicate that BMP-2, TGF-beta2, and TGF-beta3 are involved in bone formation in HO. ..
  81. Hu B, Chu S, Wang G, Gao P, Zhu D, Wang J. Association between genetic variation in transforming growth factors beta1 and beta3 and renal dysfunction in non-diabetic Chinese. Clin Exp Hypertens. 2008;30:121-31 pubmed publisher
    ..007) and urinary albumin excretion (p = 0.022), respectively. Our study demonstrated the associations of genetic variants in the TGF-beta genes with renal dysfunction and albuminuria in non-diabetic Han Chinese men but not women. ..
  82. Ulucan K, Bayraktar N, Parmaksiz E, Akcay A, Güney A. Transforming growth factor-?3 intron 5 polymorphism as a screening marker for non-syndromic cleft lip with or without cleft palate. Mol Med Rep. 2012;6:1465-7 pubmed publisher
    ..However, more studies with extended sample numbers should be carried out to clarify the effect of the examined gene region on NSCL/P. ..
  83. Bertoli Avella A, Gillis E, Morisaki H, Verhagen J, de Graaf B, van de Beek G, et al. Mutations in a TGF-β ligand, TGFB3, cause syndromic aortic aneurysms and dissections. J Am Coll Cardiol. 2015;65:1324-1336 pubmed publisher
    ..Here, we report on 43 patients from 11 families with syndromic presentations of aortic aneurysms caused by TGFB3 mutations...
  84. Yoshioka Y, Ono M, Maeda A, Kilts T, Hara E, Khattab H, et al. CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function. Bone. 2016;83:162-170 pubmed publisher
    ..In conclusion, these results show, for the first time, that CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-β3. ..
  85. Wang L, Cui J, Zhu T, Shao W, Zhao Y, Wang S, et al. Biomarkers identified for prostate cancer patients through genome-scale screening. Oncotarget. 2017;8:92055-92063 pubmed publisher
    ..Four genes (SPOCK3, SPON1, PTN and TGFB3) were selected for further evaluation after Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes ..
  86. Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley D, et al. A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing. J Cell Biol. 2006;172:1093-105 pubmed
    ..Therefore, the naturally occurring plasma-->serum-->plasma transition during wound healing orchestrates the orderly migration of dermal and epidermal cells. ..
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    ..Overexpression of TGF-beta3 and extracellular matrix proteins may represent antecedent tissue repair and therefore may be considered a significant event in the resolution of ARPC lesions. ..
  88. Wolf N, Yang W, Dunk C, Gashaw I, Lye S, Ring T, et al. Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast. Endocrinology. 2010;151:2835-45 pubmed publisher
    ..In summary, CYR61 and NOV are regulated by HIF-1alpha and TGF-beta3 in the trophoblast cell line JEG3, and their enhanced secretion could be implicated in appropriate placental invasion. ..
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    ..Therefore, our work is relevant for the development of novel cell biological, regenerative therapies for meniscus repair. ..
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    ..CD24 could play an important role in modulating expression of genes that regulate epithelial differentiation in periodontal disease. ..