TGF-beta1

Summary

Gene Symbol: TGF-beta1
Description: transforming growth factor beta 1
Alias: CED, DPD1, LAP, TGFB, TGFbeta, transforming growth factor beta-1, TGF-beta-1, latency-associated peptide, prepro-transforming growth factor beta-1
Species: human
Products:     TGF-beta1

Top Publications

  1. Wang J, Sergina N, Ko T, Gong J, Brattain M. Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity. J Biol Chem. 2004;279:40237-44 pubmed
    ..a more sensitive effector of the TGF-beta signaling pathway, which can be induced and saturated by autocrine TGF-beta, whereas CDK4 inhibition is a less sensitive effector, which can only be activated by high levels of exogenous TGF-beta ..
  2. Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, et al. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. J Cell Physiol. 1999;181:153-9 pubmed
    ..The animal model on skin fibrosis by exogenous application of growth factors developed in this study may prove useful for future studies on fibrotic disorders. ..
  3. Poole K, Gibbs P, Evans P, Sadek S, Howell W. Influence of patient and donor cytokine genotypes on renal allograft rejection: evidence from a single centre study. Transpl Immunol. 2001;8:259-65 pubmed
    ..However, due to conflicting results from this and other studies, a multi-centre collaborative study may be required to determine whether cytokine genotypes are significant, independent predictors of renal allograft rejection. ..
  4. Tambur A, Ortegel J, Ben Ari Z, Shabtai E, Klein T, Michowiz R, et al. Role of cytokine gene polymorphism in hepatitis C recurrence and allograft rejection among liver transplant recipients. Transplantation. 2001;71:1475-80 pubmed
  5. Hirashima Y, Kobayashi H, Suzuki M, Tanaka Y, Kanayama N, Terao T. Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells. J Biol Chem. 2003;278:26793-802 pubmed
    ..This represents a novel pathway by which tumor cells can regulate the plasminogen activator system-dependent cellular responses in mesothelial cells that may contribute to formation of peritoneal dissemination of ovarian cancer. ..
  6. Gourley I, DeNofrio D, Rand W, Desai S, Loh E, Kamoun M. The effect of recipient cytokine gene polymorphism on cardiac transplantation outcome. Hum Immunol. 2004;65:248-54 pubmed
    ..No other significant association was found with clinical outcomes and polymorphisms in the five cytokine genes studied in this population. ..
  7. Sato F, Narita I, Goto S, Kondo D, Saito N, Ajiro J, et al. Transforming growth factor-beta1 gene polymorphism modifies the histological and clinical manifestations in Japanese patients with IgA nephropathy. Tissue Antigens. 2004;64:35-42 pubmed
    ..These results suggest that TGF-beta1 gene polymorphisms are specifically associated with heavy proteinuria and mesangial cell proliferation in Japanese patients with IgAN, although they do not confer susceptibility to this disease...
  8. Kang H, Chae M, Park J, Kim E, Park J, Kam S, et al. Polymorphisms in TGF-beta1 gene and the risk of lung cancer. Lung Cancer. 2006;52:1-7 pubmed
    ..57-0.98; P = 0.04; and adjusted OR, 0.67; 95% CI, 0.47-0.96; P = 0.02; respectively). The TGF-beta1 -509C > T and 869T > C polymorphisms and their haplotypes may contribute to genetic susceptibility to AC and SM of the lung. ..
  9. Lee K, Ho S, Lin H, Lin S, Liu C, Huang C, et al. Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway. Am J Respir Cell Mol Biol. 2006;35:407-14 pubmed
    ..These data suggest that NE upregulates TGF-beta1 gene expression and release via My88/IRAK/NF-kappaB pathway, possibly through activation of TLR4, and shed light on a potential role of neutrophils in the pathogenesis of asthma. ..

More Information

Publications361 found, 100 shown here

  1. Kim S, Lim J, Park S, Yang J, Kim M, Kim M, et al. Transforming growth factor-beta 1 gene polymorphisms in Korean patients with pre-eclampsia. Am J Reprod Immunol. 2010;63:291-8 pubmed publisher
    ..The TGF-beta1 c.915G>C polymorphism was not detected in our population. Our findings indicate that the TGF-beta1 c.869T>C polymorphism may be a genetic risk factor for PE and IUGR-complicated PE. ..
  2. Lotz M, Clark Lewis I, Ganu V. HIV-1 transactivator protein Tat induces proliferation and TGF beta expression in human articular chondrocytes. J Cell Biol. 1994;124:365-71 pubmed
    ..of the interactions between Tat and TGF beta showed that Tat increased synthesis and TGF beta activity and TGF beta 1 mRNA levels...
  3. Morrell N, Yang X, Upton P, Jourdan K, Morgan N, Sheares K, et al. Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation. 2001;104:790-5 pubmed
    ..We conclude that PASMCs from patients with PPH exhibit abnormal growth responses to TGF-beta(1) and BMPs and that altered integration of TGF-beta superfamily growth signals may contribute to the pathogenesis of PPH. ..
  4. Pulleyn L, Newton R, Adcock I, Barnes P. TGFbeta1 allele association with asthma severity. Hum Genet. 2001;109:623-7 pubmed
    ..In this study, we show that the -509T variant on haplotype 1 is the most informative marker of the TGFbeta1 contribution to asthma severity. ..
  5. Arnulf B, Villemain A, Nicot C, Mordelet E, Charneau P, Kersual J, et al. Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood. 2002;100:4129-38 pubmed
    ..Thus, we describe a new function of Tax, as a repressor of TGF-beta1 signaling through JNK/c-Jun constitutive activation, which may play a critical role in ATL leukemogenesis. ..
  6. Hubchak S, Runyan C, Kreisberg J, Schnaper H. Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulation. J Am Soc Nephrol. 2003;14:1969-80 pubmed
    ..Thus, TGF-beta1-mediated collagen I accumulation is associated with cytoskeletal rearrangement and Rho-GTPase signaling. ..
  7. Hersh C, DeMeo D, Lazarus R, Celedon J, Raby B, Benditt J, et al. Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173:977-84 pubmed
    ..02). Polymorphisms in several genes seem to be associated with COPD-related traits other than FEV(1). These associations may identify genes in pathways important for COPD pathogenesis. ..
  8. De Ruyck K, Van Eijkeren M, Claes K, Bacher K, Vral A, De Neve W, et al. TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors. Int J Radiat Oncol Biol Phys. 2006;65:1240-8 pubmed
    ..The present study shows that homozygous variant TGFbeta1 -1.552delAGG, -509TT, and 10Pro genotypes may be associated with severe clinical radiosensitivity after gynecologic RT. ..
  9. Ferrari G, Pintucci G, Seghezzi G, Hyman K, Galloway A, Mignatti P. VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis. Proc Natl Acad Sci U S A. 2006;103:17260-5 pubmed
    ..This finding illustrates an unexpected role of VEGF and indicates that VEGF can be pharmacologically converted into an apoptotic factor, a novel approach to antiangiogenesis therapy. ..
  10. Kalo E, Buganim Y, Shapira K, Besserglick H, Goldfinger N, Weisz L, et al. Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II. Mol Cell Biol. 2007;27:8228-42 pubmed
    ..These data provide important insights into the molecular mechanisms that underlie mutant p53 "gain of function" pertaining to the TGF-beta signaling pathway. ..
  11. Bantis C, Heering P, Aker S, Kuhr N, Grabensee B, Ivens K. Influence of cytokine gene polymorphisms on IgA nephropathy. Ren Fail. 2008;30:135-40 pubmed publisher
    ..Conclusion. Our results suggest that TGF-beta1 gene Arg(25)-->Pro, TNFalpha gene G-308A, and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in Caucasian patients with IgA nephropathy...
  12. Do T, Kubba L, Du H, Sturgis C, Woodruff T. Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition. Mol Cancer Res. 2008;6:695-705 pubmed publisher
    ..0057). Collectively, these results implicate an important role for the TGF-beta/Smad3 pathway in mediating ovarian oncogenesis by enhancing metastatic potential. ..
  13. Wu G, Hasenberg T, Magdeburg R, Bönninghoff R, Sturm J, Keese M. Association between EGF, TGF-beta1, VEGF gene polymorphism and colorectal cancer. World J Surg. 2009;33:124-9 pubmed publisher
    ..The EGF 61 G/G genotype and the G allele are significantly related to colorectal cancer. The TGF-beta1 -509 T/C and VEGF 936 T/C gene polymorphisms are not related to colorectal cancer. ..
  14. Soliman G, Mohammed K, Taha A, Barrak A. The role of plasma transforming growth factor beta-1 in the development of fibrosis in patient with HCV related steatohepatitis. J Egypt Soc Parasitol. 2010;40:759-72 pubmed
    ..Plasma transforming growth factor Beta-1 (TGFB-1) is a member of large family of peptides, which has a major regulatory role in hepatic fibrosis and cirrhosis...
  15. Murphy Ullrich J, Schultz Cherry S, Hook M. Transforming growth factor-beta complexes with thrombospondin. Mol Biol Cell. 1992;3:181-8 pubmed
    ..Hence, TGF-beta can bind to TSP, and the complex forms under physiological conditions. Furthermore, TSP-associated TGF-beta is biologically active, and the binding of TGF-beta to TSP may protect TGF-beta from extracellular inactivators. ..
  16. Saharinen J, Taipale J, Keski Oja J. Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. EMBO J. 1996;15:245-53 pubmed
    ..factor-betas (TGF-betas) are produced by most cells in large latent complexes of TGF-beta and its propeptide (LAP) associated with a binding protein...
  17. Chen W, Lenschow W, Tiede K, Fischer J, Kalthoff H, Ungefroren H. Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. J Biol Chem. 2002;277:36118-28 pubmed
  18. Xiong B, Yuan H, Hu M, Zhang F, Wei Z, Gong L, et al. Transforming growth factor-beta1 in invasion and metastasis in colorectal cancer. World J Gastroenterol. 2002;8:674-8 pubmed
    ..It increased the invasive and metastatic potential of tumor by altering a tumor microenvironment. TGFbeta1 may be used as a possible biomarker. ..
  19. Watanabe Y, Kinoshita A, Yamada T, Ohta T, Kishino T, Matsumoto N, et al. A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway. J Hum Genet. 2002;47:478-83 pubmed
    ..We also estimated allele frequencies of these DNA polymorphisms among 48 Japanese individuals. Our data will provide a useful resource for the study of disease susceptibility. ..
  20. Chaturvedi N, Schalkwijk C, Abrahamian H, Fuller J, Stehouwer C. Circulating and urinary transforming growth factor beta1, Amadori albumin, and complications of type 1 diabetes: the EURODIAB prospective complications study. Diabetes Care. 2002;25:2320-7 pubmed
    ..In contrast, only circulating TGF-beta1 was related to proliferative retinopathy, and HbA(1c) largely accounted for this. These findings may indicate novel pathways for understanding mechanisms and therapeutic interventions. ..
  21. Gressner A, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med. 2006;10:76-99 pubmed
  22. Piao M, Tokunaga O. Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study. J Atheroscler Thromb. 2006;13:82-9 pubmed
    To date, the glycoprotein endoglin and its receptor complex, formed between TGFbeta and TGFbeta R-2, have been studied in tumor angiogenesis...
  23. Bosse Y, Rola Pleszczynski M. Controversy surrounding the increased expression of TGF beta 1 in asthma. Respir Res. 2007;8:66 pubmed
  24. Yan X, Liu Z, Chen Y. Regulation of TGF-beta signaling by Smad7. Acta Biochim Biophys Sin (Shanghai). 2009;41:263-72 pubmed
    ..Overexpression of Smad7 has been shown to antagonize TGF-beta-mediated fibrosis, carcinogenesis, and inflammation, suggesting a therapeutic potential of Smad7 to treat these diseases. ..
  25. Bierie B, Chung C, Parker J, Stover D, Cheng N, Chytil A, et al. Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer. J Clin Invest. 2009;119:1571-82 pubmed publisher
    ..Together, the results suggest that assessment of TGF-beta signaling pathway status may further stratify the prognosis of ER-positive patients and provide novel therapeutic approaches in the management of breast cancer. ..
  26. Teixeira A, Ribeiro R, Morais A, Lobo F, Fraga A, Pina F, et al. Combined analysis of EGF+61G>A and TGFB1+869T>C functional polymorphisms in the time to androgen independence and prostate cancer susceptibility. Pharmacogenomics J. 2009;9:341-6 pubmed publisher
    ..Combined blockage of key molecules in proliferation signaling pathways could be one of the most promising strategies for androgen-independent prostate cancer. ..
  27. Xie Y, Zeng K, Wang Y, Xu H. TGF-beta1-800G>A polymorphism and cerebral infarction in Chinese Han population. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:1166-70 pubmed
    ..05). Logistic regression analysis suggested that no genotypes could increase or reduce the risk of CI onset (P>0.05). TGF-beta1-800G>A polymorphism is not associated with CI in Han population in Hunan Province. ..
  28. Korten S, Kaifi J, Büttner D, Hoerauf A. Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia. Microbes Infect. 2010;12:555-64 pubmed publisher
    ..TGF-beta(+) cells were reduced in HIV co-infection. This finding of local and sustained TGF-beta induction by vital and dead filariae, untreated and after treatment, adds new aspects to immunomodulation by helminths. ..
  29. Liu J, Liao S, Diop Frimpong B, Chen W, Goel S, Naxerova K, et al. TGF-? blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2012;109:16618-23 pubmed publisher
  30. Takeuchi Y, Kodama Y, Matsumoto T. Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity. J Biol Chem. 1994;269:32634-8 pubmed
  31. Chang N, Mattison J, Cao H, Pratt N, Zhao Y, Lee C. Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity. Biochem Biophys Res Commun. 1998;253:743-9 pubmed
    ..Despite the fact that the mechanism for blocking TNF cytotoxicity is unknown, TIAF1 is apparently involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. ..
  32. Patel A, Scott W, Lympany P, Rippin J, Gill G, Barnett A, et al. The TGF-beta 1 gene codon 10 polymorphism contributes to the genetic predisposition to nephropathy in Type 1 diabetes. Diabet Med. 2005;22:69-73 pubmed
    ..In our study the TGF-beta 1 codon 10 polymorphism is associated with nephropathy in Type 1 diabetes and variation in this gene may contribute to the genetic predisposition to this complication in Type 1 diabetes. ..
  33. Nasu K, Nishida M, Matsumoto H, Bing S, Inoue C, Kawano Y, et al. Regulation of proliferation, motility, and contractivity of cultured human endometrial stromal cells by transforming growth factor-beta isoforms. Fertil Steril. 2005;84 Suppl 2:1114-23 pubmed
    ..Transforming growth factor-beta may be involved in the protection of the endometrium from extensive fibrosis and scarring by regulating ESC function during the perimenstrual period. ..
  34. Chow K, Szeto C, Poon P, Lau W, Lai F, Li P. Transforming growth factor-beta1 gene polymorphism in renal transplant recipients. Ren Fail. 2005;27:671-5 pubmed
    ..3+/-16.9 mL/min/1.73 m2 versus 0.1+/-10.2 mL/min/1.73 m2, p=0.04. Our results demonstrate that recipient TGF-beta1 codon 10 Leu/Leu homozygosity is a potential risk factor of kidney allograft function decline. ..
  35. Hueso M, Navarro E, Moreso F, Beltrán Sastre V, Ventura F, Grinyo J, et al. Relationship between subclinical rejection and genotype, renal messenger RNA, and plasma protein transforming growth factor-beta1 levels. Transplantation. 2006;81:1463-6 pubmed
    ..91 [n = 22] vs. 2.05 ng/mL +/- 0.76 [n = 43]; P = 0.01). There was no association between allele T and TGF-beta(1) plasma or intragraft levels. Allele T at codon 10 of the TGF-beta(1) gene is associated with a higher incidence of SCR. ..
  36. Dong Z, Yao D, Yao M, Qiu L, Zong L, Wu W, et al. Clinical impact of plasma TGF-beta1 and circulating TGF-beta1 mRNA in diagnosis of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2008;7:288-95 pubmed
    ..Both circulating TGF-beta1 and TGF-beta1 mRNA can be used as sensitive biomarkers for the diagnosis and prognosis of HBV-induced HCC. ..
  37. Wei B, Xi B, Wang R, Bai J, Chang J, Zhang Y, et al. TGFbeta1 T29C polymorphism and cancer risk: a meta-analysis based on 40 case-control studies. Cancer Genet Cytogenet. 2010;196:68-75 pubmed publisher
    ..A larger single study is still required to evaluate any association with other types of cancer or in other populations. ..
  38. Liu D, Li X, Ying B, Chen L, Wang T, Xu D, et al. Effects of single nucleotide polymorphisms 869 T/C and 915 G/C in the exon 1 locus of transforming growth factor-beta1 gene on chronic obstructive pulmonary disease susceptibility in Chinese. Chin Med J (Engl). 2010;123:390-4 pubmed
    ..The homozygous wild-type CC of 869T/C on TGFbeta1 could be a predisposing factor in COPD and those who carry the C allele might have particularly susceptibility to developing COPD. ..
  39. Tao H, Chen G, Lu X, Hu X, Chen G, Shao B. TGF-beta 1 codon 10 polymorphism is associated with cerebral SVD. Can J Neurol Sci. 2011;38:869-73 pubmed
    ..60, 95% CI, 1.14-2.25; P=0.007]. Codon 10 of TGF-beta 1 might be a risk factor for SVD, specifically in ischaemic leukoaraiosis phenotype. ..
  40. Fuzio P, Ditonno P, Rutigliano M, Battaglia M, Bettocchi C, Loverre A, et al. Regulation of TGF-?1 expression by androgen deprivation therapy of prostate cancer. Cancer Lett. 2012;318:135-44 pubmed publisher
  41. Perlman R, Schiemann W, Brooks M, Lodish H, Weinberg R. TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol. 2001;3:708-14 pubmed
    ..Our findings associate Daxx directly with the TGF-beta apoptotic-signalling pathway, and make a biochemical connection between the receptors for TGF-beta and the apoptotic machinery. ..
  42. Thannickal V, Lee D, White E, Cui Z, Larios J, Chacon R, et al. Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem. 2003;278:12384-9 pubmed
  43. Park J, Park M, Park H, Ha J, Kim S, Ahn C. TNF-alpha and TGF-beta1 gene polymorphisms and renal allograft rejection in Koreans. Tissue Antigens. 2004;64:660-6 pubmed
    ..These results would be useful for predicting high-risk group for acute rejection or CRAD in renal transplantation. ..
  44. Khalil M, El Nahas A, Blakemore A. Transforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiency. Nephron Exp Nephrol. 2005;101:e31-41 pubmed
    ..0048). There was a significant difference in haplotype distributions between CKF patients with progressive, as opposed to non-progressive disease (p = 0.0484). TGFbeta1 SNPs may be useful prognostic indicators for the progression of CKF. ..
  45. Kim Y, Lee C. The gene encoding transforming growth factor beta 1 confers risk of ischemic stroke and vascular dementia. Stroke. 2006;37:2843-5 pubmed
    ..70; P<0.05). The Pro10Leu of TGFB1 might be a risk factor of ischemic stroke and vascular dementia, especially for SVO in females. ..
  46. Zhang M, Fraser D, Phillips A. ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells. Am J Pathol. 2006;169:1282-93 pubmed
    ..Furthermore these pathways regulate distinct transcriptional and translational components of TGF-beta1 synthesis. ..
  47. Rebbeck T, Antoniou A, Llopis T, Nevanlinna H, Aittomaki K, Simard J, et al. No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study. Breast Cancer Res Treat. 2009;115:185-92 pubmed publisher
    ..01 (95%CI: 0.92-1.11) in BRCA1 carriers and 0.92 (95%CI: 0.81-1.04) in BRCA2 mutation carriers. These results do not support the hypothesis that TGFB1 L10P genotypes modify the risk of breast cancer in BRCA1 or BRCA2 mutation carriers. ..
  48. Manginas A, Tsiavou A, Chaidaroglou A, Giamouzis G, Degiannis D, Panagiotakos D, et al. Inflammatory cytokine gene variants in coronary artery disease patients in Greece. Coron Artery Dis. 2008;19:575-82 pubmed publisher
    ..Our data provide evidence that the IL-6-174G/C polymorphism may be involved in the pathogenesis of coronary artery disease, contributing to genetic susceptibility for myocardial infarction. ..
  49. Mak J, Chan Yeung M, Ho S, Chan K, Choo K, Yee K, et al. Elevated plasma TGF-beta1 levels in patients with chronic obstructive pulmonary disease. Respir Med. 2009;103:1083-9 pubmed publisher
    ..The C-509T and T869C functional polymorphisms of TGF-beta(1) gene do not represent a genetic predisposition to COPD susceptibility in Hong Kong Chinese patients. ..
  50. Valcourt U, Thuault S, Pardali K, Heldin C, Moustakas A. Functional role of Meox2 during the epithelial cytostatic response to TGF-beta. Mol Oncol. 2007;1:55-71 pubmed publisher
    ..Thus, Meox2 is primarily involved in the TGF-beta tumor suppressor pathway. ..
  51. Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, et al. Latent TGF-? structure and activation. Nature. 2011;474:343-9 pubmed publisher
    ..Sequences of all 33 TGF-? family members indicate a similar prodomain fold. The structure provides insights into the regulation of a family of growth and differentiation factors of fundamental importance in morphogenesis and homeostasis...
  52. Lin S, Yu L, Yang J, Liu Z, Karia B, Bishop A, et al. Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-? (TGF-?). J Biol Chem. 2011;286:44023-34 pubmed publisher
  53. Xu Q, Wang L, Li H, Han Q, Li J, Qu X, et al. Mesenchymal stem cells play a potential role in regulating the establishment and maintenance of epithelial-mesenchymal transition in MCF7 human breast cancer cells by paracrine and induced autocrine TGF-β. Int J Oncol. 2012;41:959-68 pubmed publisher
    ..These results suggest that MSCs may promote breast cancer metastasis by stimulating and facilitating the EMT process. ..
  54. McDaniel D, Barber W, Nguyan C, Rhodes S, May W, McDaniel L, et al. Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients. Transpl Immunol. 2003;11:107-19 pubmed
    ..Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy. ..
  55. Kim S, Jong H, Kim T, Lee J, Kim N, Hong S, et al. Transforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells. Mol Biol Cell. 2004;15:420-34 pubmed
  56. Peng H, Shintani S, Kim Y, Wong D. Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway. Neoplasia. 2006;8:1028-36 pubmed
  57. Stadnicki A, Machnik G, Klimacka Nawrot E, Wolanska Karut A, Labuzek K. Transforming growth factor-beta1 and its receptors in patients with ulcerative colitis. Int Immunopharmacol. 2009;9:761-6 pubmed publisher
    ..Increases in TGF-beta1 serum concentrations correlate with extension of disease. ..
  58. Pan H, Ding E, Hu M, Lagoo A, Datto M, Lagoo Deenadayalan S. SMAD4 is required for development of maximal endotoxin tolerance. J Immunol. 2010;184:5502-9 pubmed publisher
    ..We conclude that in THP-1 cells and primary murine cells, SMAD4 signaling is required for maximal induction of endotoxin tolerance via modulation of SHIP1 and IRAK-M. ..
  59. Lan H, Chung A. TGF-?/Smad signaling in kidney disease. Semin Nephrol. 2012;32:236-43 pubmed publisher
    ..Advances in understanding of the mechanisms of TGF-?/Smad signaling in renal fibrosis and inflammation during chronic kidney diseases should provide a better therapeutic strategy to combat kidney diseases. ..
  60. Yuan S, Ellingrod V, Schipper M, Stringer K, Cai X, Hayman J, et al. Genetic variations in TGF?1, tPA, and ACE and radiation-induced thoracic toxicities in patients with non-small-cell lung cancer. J Thorac Oncol. 2013;8:208-13 pubmed publisher
  61. Matsuyama S, Iwadate M, Kondo M, Saitoh M, Hanyu A, Shimizu K, et al. SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. Cancer Res. 2003;63:7791-8 pubmed
  62. Park K, Lo Han S, Whang Y, Lee H, Yoo Y, Lee J, et al. Single nucleotide polymorphisms of the TGFB1 gene and lung cancer risk in a Korean population. Cancer Genet Cytogenet. 2006;169:39-44 pubmed
  63. Wang S, Xiang B, Guix M, Olivares M, Parker J, Chung C, et al. Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab. Mol Cell Biol. 2008;28:5605-20 pubmed publisher
  64. Amirghofran Z, Jalali S, Ghaderi A, Hosseini S. Genetic polymorphism in the transforming growth factor beta1 gene (-509 C/T and -800 G/A) and colorectal cancer. Cancer Genet Cytogenet. 2009;190:21-5 pubmed publisher
    ..05). These data suggest that the genetic polymorphism at -509 C/T but not at -800 G/A of the TGFB1 gene may play a role in susceptibility of Iranian subjects for colorectal carcinoma. ..
  65. Wendt M, Smith J, Schiemann W. p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. J Biol Chem. 2009;284:34145-56 pubmed publisher
  66. Gu D, Zhuang L, Huang H, Cao P, Wang D, Tang J, et al. TGFB1 T29C polymorphism and breast cancer risk: a meta-analysis based on 10,417 cases and 11,455 controls. Breast Cancer Res Treat. 2010;123:857-61 pubmed publisher
    ..Many published articles have evaluated the association between the transforming growth factor beta 1 (TGFB1) T29C polymorphism and breast cancer risk. However, the results remain inconclusive...
  67. Louafi F, Martinez Nunez R, Sanchez Elsner T. MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}. J Biol Chem. 2010;285:41328-36 pubmed publisher
    ..Altogether, our data uncover an important role for miR-155 in modulating the cellular response to TGF-? with possible implications in several human diseases where homeostasis of TGF-? might be altered. ..
  68. Taubenschuß E, Marton E, Mogg M, Frech B, Ehart L, Muin D, et al. The L10P polymorphism and serum levels of transforming growth factor ?1 in human breast cancer. Int J Mol Sci. 2013;14:15376-85 pubmed publisher
    ..4 ± 7.4 ng/mL, whereas those of Leu/Leu subjects were 37.6 ± 6.0 ng/mL (p = 0.07). Thus, compared to a previous study of male subjects, we observed only a modest increase, if any, in TGF?1 levels of female Pro-allele carriers. ..
  69. Lacha J, Hribova P, Kotsch K, Brabcova I, Bartosova K, Volk H, et al. Effect of cytokines and chemokines (TGF-beta, TNF-alpha, IL-6, IL-10, MCP-1, RANTES) gene polymorphisms in kidney recipients on posttransplantation outcome: influence of donor-recipient match. Transplant Proc. 2005;37:764-6 pubmed
    ..Our data support the hypothesis that the strength of the alloimmune response after transplantation is in part genetically determined. Donor-recipient matching of cytokine gene polymorphisms has a marginal effect. ..
  70. Vogelmann R, Nguyen Tat M, Giehl K, Adler G, Wedlich D, Menke A. TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. J Cell Sci. 2005;118:4901-12 pubmed
    Transforming growth factor beta (TGFbeta) has profound growth-suppressive effects on normal epithelial cells, but supports metastasis formation in many tumour types...
  71. Stevenson S, Nelson L, Sharpe D, Thornton M. 17beta-estradiol regulates the secretion of TGF-beta by cultured human dermal fibroblasts. J Biomater Sci Polym Ed. 2008;19:1097-109 pubmed publisher
    ..A greater understanding of the cell-specific action of estrogen may help to develop therapies that will improve cutaneous wound healing in the future. ..
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    ..Early midtrimester plasma levels of sEng are predictive of subsequence occurrence and severity of preeclampsia, in terms of severity of hypertension and proteinuria, prematurity, and association with small for gestational age neonates. ..
  73. Yamauchi Y, Kohyama T, Takizawa H, Kamitani S, Desaki M, Takami K, et al. Tumor necrosis factor-alpha enhances both epithelial-mesenchymal transition and cell contraction induced in A549 human alveolar epithelial cells by transforming growth factor-beta1. Exp Lung Res. 2010;36:12-24 pubmed publisher
    ..In conclusion, TNF-alpha enhances not only EMT but also cell contraction induced by TGF-beta1. EMT might contribute to tissue fibrosis through induction of cell contraction. ..
  74. Holweg C, Baan C, Niesters H, Vantrimpont P, Mulder P, Maat A, et al. TGF-beta1 gene polymorphisms in patients with end-stage heart failure. J Heart Lung Transplant. 2001;20:979-84 pubmed
    ..The Leu(10)-->Pro (codon 10) polymorphism in the TGF-beta1 gene is associated with end-stage heart failure caused by dilated CMP and not with IHD. This observation suggests that TGF-beta1 is involved in the pathogenesis of CMP. ..
  75. Ling M, Wang X, Tsao S, Wong Y. Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cells. Biochim Biophys Acta. 2002;1570:145-52 pubmed
    Transforming growth factor beta1 (TGF beta 1) plays important roles in the regulation of cell growth and differentiation in both normal and malignant prostate epithelial cells...
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    ..Associations between beta-catenin and HIF-1alpha reflect previously detected interactions between HIF-1alpha with beta-catenin and are confirmative for presence of such reactions in human colorectal cancer. ..
  77. Miyazono K, Hellman U, Wernstedt C, Heldin C. Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization. J Biol Chem. 1988;263:6407-15 pubmed
    Human transforming growth factor beta 1 (TGF-beta 1) was purified as a latent high Mr complex from human platelets by a six-step procedure...
  78. Janssens K, Ten Dijke P, Ralston S, Bergmann C, Van Hul W. Transforming growth factor-beta 1 mutations in Camurati-Engelmann disease lead to increased signaling by altering either activation or secretion of the mutant protein. J Biol Chem. 2003;278:7718-24 pubmed
    ..b>TGFbeta-1 can only exert its many functions after going from this latent to an active state, in which the binding site of ..
  79. Fjellbirkeland L, Cambier S, Broaddus V, Hill A, Brunetta P, Dolganov G, et al. Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue. Am J Pathol. 2003;163:533-42 pubmed
    ..These data provide compelling evidence for a functional role for integrin-mediated activation of TGF-beta in control of human airway epithelial proliferation in vivo. ..
  80. Shariat S, Kattan M, Traxel E, Andrews B, Zhu K, Wheeler T, et al. Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression. Clin Cancer Res. 2004;10:1992-9 pubmed
    ..After prostate removal, postoperative TGF-beta(1) level increases in value over preoperative levels for the prediction of disease progression. ..
  81. Yoshino J, Monkawa T, Tsuji M, Inukai M, Itoh H, Hayashi M. Snail1 is involved in the renal epithelial-mesenchymal transition. Biochem Biophys Res Commun. 2007;362:63-8 pubmed
    ..This study demonstrated that Snail1 is involved in renal tubular EMT and that TGF-beta1 regulates Snail1 at the transcription and protein degradation levels. ..
  82. Pereira F, Pinheiro da Silva N, Rodart I, Carmo T, Lemaire D, Reis M. Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. J Med Virol. 2008;80:58-64 pubmed
    ..These findings suggest that TGF-beta1 codon 25 polymorphism could be a host genetic factor associated with susceptibility to HCV infection. ..
  83. Bendicho M, Guedes J, Silva N, Santana G, dos Santos R, Lyra A, et al. Polymorphism of cytokine genes (TGF-beta1, IFN-gamma, IL-6, IL-10, and TNF-alpha) in patients with chronic pancreatitis. Pancreas. 2005;30:333-6 pubmed
    ..The genotypes corresponding to the high TGF-beta1 producer phenotypes can be associated with the fibrogenesis shown with CP. ..
  84. Bian Y, Hall B, Sun Z, Molinolo A, Chen W, Gutkind J, et al. Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene. 2012;31:3322-32 pubmed publisher
  85. Hinke V, Seck T, Clanget C, Scheidt Nave C, Ziegler R, Pfeilschifter J. Association of transforming growth factor-beta1 (TGFbeta1) T29 --> C gene polymorphism with bone mineral density (BMD), changes in BMD, and serum concentrations of TGF-beta1 in a population-based sample of postmenopausal german women. Calcif Tissue Int. 2001;69:315-20 pubmed
    ..Further studies are therefore necessary to clarify the relationship between this polymorphism and BMD. ..
  86. Nagpal K, Sharma S, B Rao C, Nahid S, Niphadkar P, Sharma S, et al. TGFbeta1 haplotypes and asthma in Indian populations. J Allergy Clin Immunol. 2005;115:527-33 pubmed
    ..We also demonstrate the functional significance of these haplotypes with serum TGF-beta1 levels. These results would be valuable in elucidating the role of TGF-beta1 in asthma pathogenesis. ..
  87. Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, et al. A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell. 2009;137:87-98 pubmed publisher
    b>TGFbeta ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers. The molecular nature of this switch remains enigmatic...
  88. Gibbs J, Ornoff D, Igo H, Zeng J, Imani F. Cell cycle arrest by transforming growth factor beta1 enhances replication of respiratory syncytial virus in lung epithelial cells. J Virol. 2009;83:12424-31 pubmed publisher
    ..These findings identify a novel pathway for upregulation of virus replication and suggest a plausible mechanism for association of RSV with immune dysregulation and asthma. ..
  89. Barnett G, Elliott R, Alsner J, Andreassen C, Abdelhay O, Burnet N, et al. Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity. Radiother Oncol. 2012;105:289-95 pubmed publisher
    ..To overcome publication bias, the international Radiogenomics Consortium collected and analysed individual patient level data from both published and unpublished studies...