TGF-beta1

Summary

Gene Symbol: TGF-beta1
Description: transforming growth factor, beta 1
Alias: CED, DPD1, LAP, TGFB, TGFbeta, TGF-beta-1, latency-associated peptide, prepro-transforming growth factor beta-1, transforming growth factor beta-1
Species: human

Top Publications

  1. ncbi TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    Kazuhiko Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N238, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 172:834-42. 2004
  2. ncbi Transforming growth factor beta in tissue fibrosis
    W A Border
    Division of Nephrology, University of Utah School of Medicine, Salt Lake City 84132
    N Engl J Med 331:1286-92. 1994
  3. ncbi Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
    Laurence Levy
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cytokine Growth Factor Rev 17:41-58. 2006
  4. pmc Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    Q Yu
    Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129 USA
    Genes Dev 14:163-76. 2000
  5. ncbi The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    J S Munger
    Department of Medicine, and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6402, USA
    Cell 96:319-28. 1999
  6. ncbi TGF beta signals through a heteromeric protein kinase receptor complex
    J L Wrana
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 71:1003-14. 1992
  7. pmc Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-β1: role of TGF-β1 in HCV replication
    Lance D Presser
    Department of Microbiology and Immunology, H M Bligh Cancer Research Laboratories, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Virology 412:284-96. 2011
  8. doi TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease
    Filippo Caraci
    Department of Pharmaceutical Sciences, University of Catania, Italy
    CNS Neurosci Ther 17:237-49. 2011
  9. pmc Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    Yasushi Kojima
    Cancer Research UK Stromal Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester M20 4BX, United Kingdom
    Proc Natl Acad Sci U S A 107:20009-14. 2010
  10. ncbi SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
    T Tsukazaki
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 95:779-91. 1998

Research Grants

  1. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2005
  2. Smurf Ubiquitin Ligases in Xenopus Development
    GERALD THOMSEN; Fiscal Year: 2005
  3. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 1993
  4. LIGAND BINDING DOMAINS OF TGF BETA RECEPTOR
    ANDRZEJ KREZEL; Fiscal Year: 1999
  5. LIGAND BINDING DOMAINS OF TGF BETA RECEPTOR
    ANDRZEJ KREZEL; Fiscal Year: 2000
  6. TGF-beta polymorphisms and breast cancer in families
    Boris Pasche; Fiscal Year: 2013
  7. TGF BETA RECEPTOR AND TUMOR PROGRESSION
    Luzhe Sun; Fiscal Year: 2003
  8. TGF BETA RECEPTOR AND TUMOR PROGRESSION
    Luzhe Sun; Fiscal Year: 2006
  9. TGF BETA RECEPTOR AND TUMOR PROGRESSION
    Luzhe Sun; Fiscal Year: 2006
  10. EXPRESSION OF TUBERCULOSIS IN THE LUNG
    Elizabeth Rich; Fiscal Year: 1993

Detail Information

Publications320 found, 100 shown here

  1. ncbi TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    Kazuhiko Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N238, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 172:834-42. 2004
    ..these cells do not protect recipient mice from colitis in the SCID transfer model in vivo, and, in addition, CD4+LAP+, but not CD4+LAP- T cells from normal mice protect recipient mice from colitis in this model...
  2. ncbi Transforming growth factor beta in tissue fibrosis
    W A Border
    Division of Nephrology, University of Utah School of Medicine, Salt Lake City 84132
    N Engl J Med 331:1286-92. 1994
  3. ncbi Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
    Laurence Levy
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cytokine Growth Factor Rev 17:41-58. 2006
    ....
  4. pmc Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    Q Yu
    Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129 USA
    Genes Dev 14:163-76. 2000
    ..These observations suggest that coordinated CD44, MMP-9, and TGF-beta function may provide a physiological mechanism of tissue remodeling that can be adopted by malignant cells to promote tumor growth and invasion...
  5. ncbi The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    J S Munger
    Department of Medicine, and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6402, USA
    Cell 96:319-28. 1999
    ..We show that TGF beta 1 LAP is a ligand for the integrin alpha v beta 6 and that alpha v beta 6-expressing cells induce spatially ..
  6. ncbi TGF beta signals through a heteromeric protein kinase receptor complex
    J L Wrana
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 71:1003-14. 1992
    ..This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors...
  7. pmc Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-β1: role of TGF-β1 in HCV replication
    Lance D Presser
    Department of Microbiology and Immunology, H M Bligh Cancer Research Laboratories, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Virology 412:284-96. 2011
    ..Collectively, these observations provide insight into the mechanism of TGF-β1 activation, which likely manifest in liver fibrosis associated with hepatitis C infection...
  8. doi TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease
    Filippo Caraci
    Department of Pharmaceutical Sciences, University of Catania, Italy
    CNS Neurosci Ther 17:237-49. 2011
    ..In the present review, we examine the evidence for a neuroprotective role of TGF-β1 in AD, and discuss the TGF-β1 signaling pathway as a new pharmacological target for the treatment of AD...
  9. pmc Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    Yasushi Kojima
    Cancer Research UK Stromal Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester M20 4BX, United Kingdom
    Proc Natl Acad Sci U S A 107:20009-14. 2010
    ..This autocrine-signaling mechanism may prove to be an attractive therapeutic target to block the evolution of tumor-promoting CAFs...
  10. ncbi SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
    T Tsukazaki
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 95:779-91. 1998
    ..SARA functions to recruit Smad2 to the TGFbeta receptor by controlling the subcellular localization of Smad2 and by interacting with the TGFbeta receptor ..
  11. pmc Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    Shigehiro Doi
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:8655-65. 2011
    ..These results have raised the possibility that secreted Klotho may function as an endogenous anti-EMT factor by inhibiting multiple growth factor signaling pathways simultaneously...
  12. ncbi Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    S Cheifetz
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 267:19027-30. 1992
    ..TGF-beta however is binding with high affinity to only a small fraction of the available endoglin molecules, suggesting that some rate-limiting event is required to sustain TGF-beta binding to endoglin...
  13. ncbi TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells
    Naoki Hagimoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 168:6470-8. 2002
    ..Our results demonstrate a novel role of TGF-beta 1 in the pathophysiology of pulmonary fibrosis as an enhancer of Fas-mediated apoptosis of lung epithelial cells...
  14. ncbi Tumor-derived TGFbeta-1 induces dendritic cell apoptosis in the sentinel lymph node
    Manabu Ito
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 01 8543, Japan
    J Immunol 176:5637-43. 2006
    ..We found that the incidence of apoptosis among DCs was higher in SLNs than in non-SLNs, as were levels of TGFbeta-1...
  15. ncbi Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex
    Francisco J Blanco
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    J Cell Physiol 204:574-84. 2005
    ..By contrast, endoglin appears to interfere with TGF-beta/ALK-5 signaling. These results suggest that the functional association of endoglin with ALK-1 is critical for the endothelial responses to TGF-beta...
  16. doi Transforming growth factor-β1 promotes lung adenocarcinoma invasion and metastasis by epithelial-to-mesenchymal transition
    Hui Jun Zhang
    Tenth People Hospital of Tongji University, Shanghai, China
    Mol Cell Biochem 355:309-14. 2011
    ..More importantly, cell motility and invasion were also enhanced in the EMT process. These results indicated that TGF-β1 may promote lung adenocarcinoma invasion and metastasis via the mechanism of EMT...
  17. ncbi TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Stroke 37:2667-71. 2006
    ..We therefore investigated 5 polymorphisms in the TGF-beta1 gene (-800 G/A, -509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study...
  18. ncbi Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins
    N W Morrell
    Department of Medicine, University of Cambridge, Addenbrooke s and Papworth Hospitals, Cambridge, United Kingdom
    Circulation 104:790-5. 2001
    ..We postulated that pulmonary artery smooth muscle cells (PASMCs) from patients with PPH might demonstrate abnormal growth responses to TGF-beta superfamily members...
  19. doi Transforming growth factor-β 1 enhances the invasiveness of breast cancer cells by inducing a Smad2-dependent epithelial-to-mesenchymal transition
    Zhi Dong Lv
    Department of Breast Surgery, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, PR China
    Oncol Rep 29:219-25. 2013
    ..05). These data suggested that EMT of breast cancer induced by TGF-β1 is dependent on Smad2 signaling and promotes breast cancer cell metastasis...
  20. pmc High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells
    Yingze Zhang
    Division of Pulmonary, Allergy and Critical Care Medicine, Richard P and Dorothy P Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e20319. 2011
    b>Transforming growth factor beta 1 (TGFβ1) plays a major role in many lung diseases including lung cancer, pulmonary hypertension, and pulmonary fibrosis...
  21. doi Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways
    Xiao Feng Chen
    Department of Thoracic Surgury, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China
    Mol Biol Rep 39:3549-56. 2012
    ....
  22. pmc The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1)
    Zhiqiang Chen
    General Surgery Department of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 287:17016-28. 2012
    ..This study demonstrates that chelators inhibit the TGF-β-induced EMT via a process consistent with NDRG1 up-regulation and elucidates the mechanism of their activity...
  23. pmc Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta
    A Hildebrand
    Cancer Research Center, La Jolla Cancer Research Foundation, CA 92037
    Biochem J 302:527-34. 1994
    ..They may regulate TGF-beta activities by sequestering TGF-beta into extracellular matrix...
  24. pmc Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts
    Rui Ming Liu
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:16239-47. 2010
    ..Our data suggest that increased generation of ROS by Nox4 mediates TGF-beta1-induced PAI-1 gene expression at least in part through oxidative modification and inhibition of MKP-1 leading to a sustained activation of JNK and p38 MAPKs...
  25. pmc c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3
    Jos L J van der Velden
    Department of Pathology, Health Sciences Research Facility, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 44:571-81. 2011
    ....
  26. pmc NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3
    Saleh Ismail
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah Health Sciences Centerand VA Medical Center, Salt Lake City, Utah 84132, USA
    Am J Physiol Lung Cell Mol Physiol 296:L489-99. 2009
    ..IGFBP-3 increases NOX4 gene expression, resulting in HPASMC proliferation. These observations add to our understanding hypoxic pulmonary vascular remodeling...
  27. ncbi Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells
    Jing Wang
    University of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Cancer Res 68:3152-60. 2008
    ..Stable transfection of a dominant-negative transforming growth factor beta (TGFbeta) type II receptor (DNRII) into FET cells that express autocrine TGFbeta shows loss of TGFbeta signaling and ..
  28. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
    ..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors...
  29. doi Inflammatory cytokine gene variants in coronary artery disease patients in Greece
    Athanassios Manginas
    Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
    Coron Artery Dis 19:575-82. 2008
    ..Abundant evidence supports the central role of inflammatory cytokines in immune responses mediating the pathogenesis of atherosclerosis, coronary artery disease, and its complications, such as myocardial infarction and unstable angina...
  30. ncbi Regulation of TGF-beta signaling by Smad7
    Xiaohua Yan
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Acta Biochim Biophys Sin (Shanghai) 41:263-72. 2009
    ..Overexpression of Smad7 has been shown to antagonize TGF-beta-mediated fibrosis, carcinogenesis, and inflammation, suggesting a therapeutic potential of Smad7 to treat these diseases...
  31. pmc TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer
    Shinako Araki
    Department of Oncology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390 8807, USA
    J Clin Invest 120:290-302. 2010
    ..Identification of Hdm2 as a downstream target of TGF-beta1 represents a critical prosurvival mechanism in cancer progression and provides another point for therapeutic intervention in late-stage cancer...
  32. ncbi MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration
    Jing Ma
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Blood 109:987-94. 2007
    ..Taken together, our findings suggest that MCP-1 mediates TGF-beta-stimulated angiogenesis by enhancing migration of mural cells toward ECs and thus promoting the maturation of new blood vessels...
  33. ncbi Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells
    Shaoping Xie
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Am J Physiol Lung Cell Mol Physiol 288:L68-76. 2005
    ..TGF-beta 1-stimulated CTGF expression is mediated by mechanisms involving ERK and JNK pathways and is downregulated by IL-4 and IL-13 through modulation of Smad and ERK signals...
  34. pmc Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
    Cedric Coulouarn
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 47:2059-67. 2008
    ..Finally, we established that the TGF-beta gene expression signature possessed a predictive value for tumors other than HCC...
  35. doi The single-molecule mechanics of the latent TGF-β1 complex
    Lara Buscemi
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Curr Biol 21:2046-54. 2011
    ..Together with its latency-associated peptide (LAP), TGF-β1 binds to the latent TGF-β1-binding protein-1 (LTBP-1), which is part of the extracellular matrix (ECM)...
  36. pmc Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis
    Cam T Ha
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Biol Reprod 83:27-35. 2010
    ..We have observed that PSGs induce transforming growth factor beta 1 (TGFB1), which among its other diverse functions inhibits T-cell function and has proangiogenic ..
  37. doi Early defect of transforming growth factor β1 formation in Huntington's disease
    Giuseppe Battaglia
    Neuropharmacology Unit, IRCCS Neuromed, Pozzilli, Italy
    J Cell Mol Med 15:555-71. 2011
    ....
  38. pmc Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation
    Y Bian
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, Bethesda, MD, USA
    Oncogene 31:3322-32. 2012
    ....
  39. ncbi Potentiation of HIV-1 expression in microglial cells by nicotine: involvement of transforming growth factor-beta 1
    R Bryan Rock
    Center for Infectious Diseases and Microbiology Translational Research, Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 3:143-9. 2008
    ..We also found that nicotine robustly altered the gene expression profile of HIV-1-infected microglia and that the transforming growth factor-beta1 is involved in the enhanced expression of HIV-1 by nicotine...
  40. pmc Snail involves in the transforming growth factor β1-mediated epithelial-mesenchymal transition of retinal pigment epithelial cells
    Hui Li
    Department of Ophthalmology, Shanghai First People s Hospital, Affiliate of Shanghai Jiaotong University, Shanghai, China
    PLoS ONE 6:e23322. 2011
    ..However, the function of Snail in RPE cells undergoing EMT is largely unknown...
  41. pmc Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction
    Soma Meran
    Institute of Nephrology, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 286:17618-30. 2011
    ..In summary, HA facilitates TGF-β1-dependent fibroblast proliferation through promoting interaction between CD44 and EGFR, which then promotes specific MAPK/ERK activation, inducing cellular proliferation...
  42. ncbi The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  43. pmc TGF-β1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells
    S B Pakala
    Department of Biochemistry and Molecular Biology and Institute of Coregulator Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Oncogene 30:2230-41. 2011
    ....
  44. doi Relationship between CCL5 and transforming growth factor-β1 (TGFβ1) in breast cancer
    M C Hartmann
    Division of Surgery, School of Medicine, National University of Ireland Galway, Ireland
    Eur J Cancer 47:1669-75. 2011
    ..Hormonal control of CCL5, and a potential relationship with TGFβ1, was also investigated...
  45. pmc MiR-23a regulates TGF-β-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells
    Mengru Cao
    Department of Internal Medicine, Division of Pulmonary Medicine Infection and Oncology, Nippon Medical School, Tokyo 113 8603, Japan
    Int J Oncol 41:869-75. 2012
    ..These findings suggest that miR-23a regulates TGF-β-induced EMT by targeting E-cadherin in lung cancer cells and may be useful as a new therapeutic target in NSCLC...
  46. doi WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity
    György Szláma
    Institute of Enzymology, Budapest, Hungary
    FEBS J 277:5040-50. 2010
    ..It is suggested that the physical association of WFIKKN proteins with these growth factors may localize their action and thus help to establish growth factor gradients in the extracellular space...
  47. ncbi Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-beta1
    Takayuki Naito
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima City 734 8551, Japan
    Am J Physiol Renal Physiol 286:F278-87. 2004
    ..In conclusion, this study has demonstrated that ANG II-induced activation of latent TGF-beta1 in HMC operates via TSP-1. Furthermore, ANG II-induced TSP-1 production is dependent on p38 MAPK and JNK signaling...
  48. ncbi The gene encoding transforming growth factor beta 1 confers risk of ischemic stroke and vascular dementia
    Younyoung Kim
    Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang, Kyonggi do 431 060, South Korea
    Stroke 37:2843-5. 2006
    ..We investigated the association of the polymorphism in TGFB1 with ischemic stroke and vascular dementia...
  49. pmc Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells
    Irina Kolosova
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 226:1248-54. 2011
    ..Both Smad2/3 and p38 MAPK had a role in regulation of TGF-β1-induced collagen expression. Furthermore, these data demonstrate that Smads and p38 MAPK differentially regulate EMT-related changes in pulmonary epithelial cells...
  50. ncbi Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome
    Enid R Neptune
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 33:407-11. 2003
    ..These data indicate that matrix sequestration of cytokines is crucial to their regulated activation and signaling and that perturbation of this function can contribute to the pathogenesis of disease...
  51. pmc The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--β1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells
    Mark D Sides
    Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Respir Cell Mol Biol 44:852-62. 2011
    ..Our in vitro data may help to explain the observation that patients with IPF demonstrating positive staining for LMP1 in lung epithelial cells have a more rapid demise than patients in whom LMP1 is not detected...
  52. ncbi TGFbeta1 allele association with asthma severity
    L J Pulleyn
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Hum Genet 109:623-7. 2001
    ..In this study, we show that the -509T variant on haplotype 1 is the most informative marker of the TGFbeta1 contribution to asthma severity...
  53. doi Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway
    Young A Yoo
    Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea University, Seoul 136 705, Korea
    Carcinogenesis 29:480-90. 2008
    ..Additionally, our findings are the first to suggest a role and mechanism for Shh signaling as it relates to the metastatic potential of gastric cancer, thereby indicating potential therapeutic molecular targets to decrease metastasis...
  54. pmc Quantitative analysis of transient and sustained transforming growth factor-β signaling dynamics
    Zhike Zi
    BIOSS Centre for Biological Signalling Studies and Center for Biological Systems Analysis ZBSA, University of Freiburg, Freiburg, Germany
    Mol Syst Biol 7:492. 2011
    ..Our results suggest that long-term switch-like signaling responses in the TGF-β pathway might be critical for cell fate determination...
  55. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
    Fibrosis is characterized by elevated transforming growth factor beta (TGFbeta) signaling, resulting in extracellular matrix accumulation and increased PAI-1 (plasminogen activator inhibitor) expression...
  56. ncbi TGFbeta and Wnt pathway cross-talk
    Liliana Attisano
    Department of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Cancer Metastasis Rev 23:53-61. 2004
    Transforming growth factor-betas (TGFbeta) and Wnts represent two distinct families of secreted molecules each of which utilizes different signaling pathways to elicit their biological effects...
  57. ncbi Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
    Sylviane Dennler
    INSERM U697, Hopital Saint Louis, Pavillon Bazin, 1 avenue Claude Vellefaux, 75010 Paris, France
    Cancer Res 67:6981-6. 2007
    ..We thus identify TGF-beta as a potent transcriptional inducer of Gli transcription factors. Targeting the cooperation of Hh and TGF-beta signaling may provide new therapeutic opportunities for cancer treatment...
  58. ncbi Latent transforming growth factor-beta: structural features and mechanisms of activation
    J S Munger
    Department of Cell Biology, New York University, New York, USA
    Kidney Int 51:1376-82. 1997
    ..TGF-beta s are secreted in a latent form due to noncovalent association with latency associated peptide (LAP), which is a homodimer formed from the propeptide region of TGF-beta...
  59. ncbi Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer
    Sambasivarao Damaraju
    Cross Cancer Institute, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 12:2545-54. 2006
    ....
  60. ncbi Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers
    E B Jude
    Department of Medicine and Diabetes, Manchester Royal Infirmary and School of Biological Sciences, University of Manchester, Manchester, UK
    Diabet Med 19:440-7. 2002
    ..We also compared the TGF-betas with those of chronic venous ulcers...
  61. pmc The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas
    Andrej Valkov
    Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
    PLoS ONE 6:e17507. 2011
    ..We aimed to investigate the prognostic impact of TGF-β1, NF-κB p105, PKC-ζ, Par-6α, E-cadherin and vimentin in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STSs)...
  62. ncbi Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples
    C N Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Int J Radiat Biol 82:577-86. 2006
    ..subcutaneous fibrosis were found for single nucleotide polymorphisms (SNP) in TGFB1 (transforming growth factor beta 1 gene), XRCC1 (X-ray repair cross-complementing 1 gene), XRCC3 (X-ray repair cross-complementing 3 ..
  63. doi Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity
    Oliver Zschenker
    Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Radiother Oncol 97:26-32. 2010
    ..To examine the association of polymorphisms in ATM (codon 158), GSTP1 (codon 105), SOD2 (codon 16), TGFB1 (position -509), XPD (codon 751), and XRCC1 (codon 399) with fibrosis and also individual radiosensitivity...
  64. pmc A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity
    Jennifer L Sargent
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Invest Dermatol 130:694-705. 2010
    ..Since transforming growth factor-beta (TGFbeta) has been implicated in driving fibrosis in systemic sclerosis, a mechanism-derived gene expression signature was ..
  65. ncbi Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
    K A Lewis
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 404:411-4. 2000
    ..The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as co-receptors modulating ligand-receptor sensitivity, selectivity and function...
  66. ncbi Transforming growth factor-beta and the immune response to malignant disease
    Beverly A Teicher
    Genzyme Corporation, Framingham, Massachusetts 01701 9322, USA
    Clin Cancer Res 13:6247-51. 2007
    ..Phase I clinical trials of an inhibitor of TGF-beta receptor type I kinase activity and a TGF-beta neutralizing antibody are under way...
  67. ncbi SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 91:915-25. 2004
    ..Although it has been appreciated that transforming growth factor beta 1 (TGF-beta1) induces SPARC and collagen type I, we have recently shown that SPARC regulates the ..
  68. pmc ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells
    Mei Zhang
    Institute of Nephrology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN UK
    Am J Pathol 169:1282-93. 2006
    ..Furthermore these pathways regulate distinct transcriptional and translational components of TGF-beta1 synthesis...
  69. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  70. ncbi TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients
    S V V Kalyana Chakravarthi
    Kallam Anji Reddy Molecular Genetics Laboratory, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 46:121-5. 2005
    ..To identify mutations in the TGFBI gene in Indian patients with lattice corneal dystrophy (LCD) or granular corneal dystrophy (GCD) and to look for genotype-phenotype correlations...
  71. pmc HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
    Sylvie Thuault
    Ludwig Institute for Cancer Research, Box 595 Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 283:33437-46. 2008
    ..The data propose that HMGA2 acts in a gene-specific manner to orchestrate the transcriptional network necessary for the EMT program...
  72. ncbi TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage
    Anna Dubrovska
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, SE 751 24 Uppsala, Sweden
    Oncogene 24:2289-97. 2005
    ..Transforming growth factor-beta (TGFbeta) is a potent regulator of growth, apoptosis and invasiveness of tumor cells, including breast cancer cells...
  73. pmc Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro
    Kimberly A Brown
    Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Breast Cancer Res 6:R215-31. 2004
    ..Although there is growing interest in TGF-beta1-mediated EMT, the phenotype is limited to only a few murine cell lines and mouse models...
  74. ncbi Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Bone Miner Res 13:1569-76. 1998
    ..Thus, analysis of the TGF-beta1 genotype may be useful in the prevention and management of osteoporosis...
  75. ncbi Transforming growth factor-beta 1 gene polymorphisms and cardiovascular disease in hemodialysis patients
    Madhumathi Rao
    Division of Nephrology and Division of Biostatistics and Clinical Care Research, Tufts New England Medical Center, Boston, Massachusetts, USA
    Kidney Int 66:419-27. 2004
    ....
  76. ncbi Escaping from the TGFbeta anti-proliferative control
    Joan Seoane
    Institucio Catalana de Recerca i Estudis Avancats ICREA, Medical Oncology Program Vall d Hebron University Hospital Research Institute, Barcelona, Spain
    Carcinogenesis 27:2148-56. 2006
    Transforming growth factor-beta (TGFbeta) has a crucial role in tissue homeostasis and disruption of the TGFbeta pathway has been implicated in many human diseases including cancer...
  77. ncbi Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae
    Juan F Santibanez
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, Madrid, Spain
    Cardiovasc Res 77:791-9. 2008
    ..The aim of this work was to assess the location of ALK1 in endothelial caveolae as well as to study the role of caveolin-1 on the TGF-beta/ALK1 signalling pathway...
  78. pmc Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition
    Thuy Vy Do
    Northwestern University, 2205 Tech Drive, Hogan 4 150, Evanston, IL 60208, USA
    Mol Cancer Res 6:695-705. 2008
    ..0057). Collectively, these results implicate an important role for the TGF-beta/Smad3 pathway in mediating ovarian oncogenesis by enhancing metastatic potential...
  79. doi EGF/TGFβ1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332
    Petra Richter
    Institute of Pathology, University Hospital Jena, Jena, Germany
    J Oral Pathol Med 40:46-54. 2011
    ..In summary we are able to show that EMT in OSCC is mediated by multiple growth factors and is accompanied by laminin γ2 chain up-regulation evidencing the existence of an intermediate Vim(+) /Ln332(+) EMT phenotype as seen in situ...
  80. ncbi Effects of TGF-β1 on the proliferation and differentiation of human periodontal ligament cells and a human periodontal ligament stem/progenitor cell line
    Shinsuke Fujii
    Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Cell Tissue Res 342:233-42. 2010
    ..Thus, TGF-β1 seems to play an important role in inducing fibroblastic differentiation of PDL stem/progenitor cells and in maintaining the PDL apparatus under physiological conditions...
  81. pmc PAI-1 mediates the TGF-beta1+EGF-induced "scatter" response in transformed human keratinocytes
    Jennifer Freytag
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA
    J Invest Dermatol 130:2179-90. 2010
    ....
  82. doi Genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility: a population-based case-control study in China
    Yongjing Zhang
    Department of Epidemiology and Health Statistics, Zhejiang University, School of Medicine, 388 Yuhang Tang Road, Hangzhou, Zhejiang 310058, China
    Cancer Lett 275:102-8. 2009
    ..05-1.66). Our findings indicate that the distributions of polymorphisms in TGF-beta1 and its receptors genes vary greatly among different ethnic groups, and these polymorphisms might contribute to the colorectal cancer susceptibility...
  83. pmc Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma
    Yasunori Sato
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Am J Pathol 177:141-52. 2010
    ..These results suggest that epithelial-mesenchymal transition induced by TGF-beta1/Snail activation is closely associated with the aggressive growth of cholangiocarcinoma, resulting in a poor prognosis...
  84. ncbi Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation
    Shi Long Lu
    Department of Otolaryngology, Oregon Health and Science University, Portland, USA
    Cancer Res 64:4405-10. 2004
    ..These phenotypes correlated with enhanced Smad signaling in transgenic epithelia and stroma. Our study suggests that TGF-beta1 overexpression at early stages of HNSCC formation provides a tumor promoting microenvironment...
  85. doi TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2
    Marcelo G Binker
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Biochem Biophys Res Commun 405:140-5. 2011
    ..The multifunctional cytokine transforming growth factor beta 1 (TGF-β1) has been shown to increase both secretion of MMP-2 and invasion by several pancreatic ..
  86. ncbi Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection--association between TGF-beta1 polymorphisms and hepatocellular carcinoma
    Kiyoshi Migita
    Clinical Research Center, NHO Nagasaki Medical Center, Kubara 2 1001 1, Omura 856 8562, Japan
    J Hepatol 42:505-10. 2005
    ..In this study, we determined the frequencies of the genotypes associated with the polymorphism of the cytokines genes, and investigated their association with the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) carriers...
  87. pmc Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression
    S Dangi-Garimella
    Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    Oncogene 30:1002-8. 2011
    ....
  88. pmc MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}
    Fethi Louafi
    JunkRNA Laboratory, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 285:41328-36. 2010
    ..Altogether, our data uncover an important role for miR-155 in modulating the cellular response to TGF-β with possible implications in several human diseases where homeostasis of TGF-β might be altered...
  89. pmc A role for the TGFbeta-Par6 polarity pathway in breast cancer progression
    Alicia M Viloria-Petit
    Center for Systems Biology, Samuel Lunenfeld Research Institute, Room 1078 Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 106:14028-33. 2009
    ..and an orthotopic mouse model of breast cancer, we reveal that Par6 signaling, which is regulated directly by TGFbeta, plays a role in breast cancer metastasis...
  90. ncbi Role of interleukin-10 and transforming growth factor beta 1 in otitis media with effusion
    Shou Qin Zhao
    Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing 100730, China
    Chin Med J (Engl) 122:2149-54. 2009
    ....
  91. doi Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia
    Simone Korten
    Institute of Medical Microbiology, Immunology and Parasitology IMMIP, University Clinic Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Microbes Infect 12:555-64. 2010
    ..TGF-beta(+) cells were reduced in HIV co-infection. This finding of local and sustained TGF-beta induction by vital and dead filariae, untreated and after treatment, adds new aspects to immunomodulation by helminths...
  92. pmc Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter
    Adele Hannigan
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, United Kingdom
    J Clin Invest 120:2842-57. 2010
    ....
  93. doi A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin
    Aurélie Chabanon
    Institut National de la Sante et de la Recherche Medicale, Villejuif, France
    Stem Cells 26:3150-61. 2008
    ....
  94. pmc Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis
    Mario C Rico
    Department of Physiology, The Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, PA 19140, USA
    Transl Res 152:95-8. 2008
    ..Plasma levels of TSP1 and tissue growth factor beta (TGFbeta) were determined by standard enzyme-linked immunosorbent assay, and cytokines were measured by protein profiling ..
  95. doi MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1
    Olga Tatti
    Departments of Pathology and Virology, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland
    Exp Cell Res 314:2501-14. 2008
    ..Current results identify MT1-MMP-mediated proteolytic processing of ECM-bound LTBP-1 as a mechanism to release latent TGF-beta from the subendothelial matrix...
  96. ncbi Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population
    G Kaur
    Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Tissue Antigens 69:113-20. 2007
    ..The data can be used for anthropological comparisons, as well as for association studies with different diseases and for use in transplant situations involving acute and chronic rejection...
  97. doi Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells
    Kristine C Nyhan
    UCD Diabetes Research Centre, School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield Dublin 4, Ireland
    Biochim Biophys Acta 1803:1386-95. 2010
    ..These data suggest that Jagged/Notch signalling is required for a subset of TGFβ1-responsive genes, and that complex signalling pathways are involved in the crosstalk between TGFβ1 and Notch cascades in kidney epithelia...
  98. doi Transforming growth factor beta-1 and interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection
    Mary White
    Department of Anaesthesia, St James Hospital, Dublin 8, Ireland Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Cytokine 50:322-7. 2010
    ..Transforming growth factor beta-1 (TGFbeta-1) predominantly inhibits inflammation and may simultaneously promote IL-17 production...
  99. pmc MicroRNA-24 regulates the processing of latent TGFβ1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN
    Coralia Luna
    Department of Ophthalmology, Duke University, Durham, North Carolina 27710, USA
    J Cell Physiol 226:1407-14. 2011
    ..to alterations of cellular functions in the trabecular meshwork (TM), including the up-regulation of transforming growth factor beta 1 (TGFβ1), that can potentially contribute to the pathogenesis of glaucoma...
  100. pmc A conserved stem loop motif in the 5'untranslated region regulates transforming growth factor-β(1) translation
    Robert H Jenkins
    Institute of Nephrology, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, United Kingdom
    PLoS ONE 5:e12283. 2010
    ..These data identify a highly conserved element within the TGF-β(1) 5'UTR that forms stable secondary structure, and is responsible for the inherent low translation efficiency of this cytokine...
  101. pmc X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression
    Jason R Neil
    Department of Pharmacology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Biol Chem 284:21209-17. 2009
    ..Collectively our findings have defined a novel role for xIAP in mediating oncogenic signaling by TGF-beta in breast cancer cells...

Research Grants75

  1. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2005
    ..The action of TGFbeta may be a critical determinant in the overexpression of PTHrP by carcinomas and play an important role in the ..
  2. Smurf Ubiquitin Ligases in Xenopus Development
    GERALD THOMSEN; Fiscal Year: 2005
    The TGFbeta superfamily regulates cell growth and differentiation. During Xenopus development, Nodal, Vg1 and activin-related signals induce endoderm and mesoderm, and BMP signals pattern these tissues and regulate ectodermal cell fate...
  3. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 1993
    ..By contrast, AM are weak producers of transforming growth factor beta (TGFbeta), a deactivating cytokine...
  4. LIGAND BINDING DOMAINS OF TGF BETA RECEPTOR
    ANDRZEJ KREZEL; Fiscal Year: 1999
    ..application's objective is the structural explanation of the specificity of the transforming growth factor beta (TGFbeta) binding to the TGFbeta receptors (TbetaR)...
  5. LIGAND BINDING DOMAINS OF TGF BETA RECEPTOR
    ANDRZEJ KREZEL; Fiscal Year: 2000
    ..application's objective is the structural explanation of the specificity of the transforming growth factor beta (TGFbeta) binding to the TGFbeta receptors (TbetaR)...
  6. TGF-beta polymorphisms and breast cancer in families
    Boris Pasche; Fiscal Year: 2013
    ..This project will study 65 genes of the TGF-2 pathway in 5357 women with breast cancer and their unaffected sisters and determine which genes are associated with breast cancer risk. ..
  7. TGF BETA RECEPTOR AND TUMOR PROGRESSION
    Luzhe Sun; Fiscal Year: 2003
    Many carcinoma cells often express higher levels of transforming growth factor beta (TGFbeta) than their normal counterparts...
  8. TGF BETA RECEPTOR AND TUMOR PROGRESSION
    Luzhe Sun; Fiscal Year: 2006
    Many carcinoma cells often express higher levels of transforming growth factor beta (TGFbeta) than their normal counterparts...
  9. TGF BETA RECEPTOR AND TUMOR PROGRESSION
    Luzhe Sun; Fiscal Year: 2006
    Many carcinoma cells often express higher levels of transforming growth factor beta (TGFbeta) than their normal counterparts...
  10. EXPRESSION OF TUBERCULOSIS IN THE LUNG
    Elizabeth Rich; Fiscal Year: 1993
    ..By contrast, AM are weak producers of transforming growth factor beta (TGFbeta), a deactivating cytokine...
  11. The Role of Plexin C1 in Scleroderma Related Interstitial Lung Disease
    Aditi Mathur; Fiscal Year: 2013
    ..ILD) is a leading cause of death in this population and is associated with hyper-responsiveness to transforming growth factor beta 1 (TGF-[unreadable]1) and accumulation of fibrocytes in the blood and lung parenchyma of affected ..
  12. Integrin-mediated Regulation of TGFbeta Signaling and Tumorigenesis
    WILLIAM SCHIEMANN; Fiscal Year: 2013
    ..Moreover, translating our epigenetic biomarkers to clinical diagnostic applications will enable science and medicine to significantly improve the overall survival of patients with TNBCs. ..
  13. Role of TGFbeta superfamily in Broncopulmonary Dysplasia
    SIMON JAMES CONWAY; Fiscal Year: 2013
    ..Aim 3 will determine the mechanism(s) by which absence of the downstream TGF-[unreadable]2 effector ECM protein, [unreadable]igH3, is sufficient to cause BPD. ..
  14. Transforming growth factor beta1, MicroRNAs and Diabetic Nephropathy
    Rama Natarajan; Fiscal Year: 2012
    ..This project proposes to identify novel new mechanisms involved that could lead to the development of sorely needed newer therapies to reduce the morbidity and mortality of diabetic nephropathy. ..
  15. Targeting epithelial cells to treat pulmonary fibrosis
    Dean Sheppard; Fiscal Year: 2013
    ..is a consequence of n-going epithelial stress and apoptosis, which leads to activation of extracellular latent TGFbeta by the alpha nu beta integrin on alveolar epithelial cells, which in turn induces progressive fibrosis at least ..
  16. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    Jennifer Van Eyk; Fiscal Year: 2009
    ..In 2006, we showed that excessive TGFbeta signaling plays a major role in the pathogenesis of MFS in a mouse model for MFS...
  17. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..In 2006, we showed that excessive TGFbeta signaling plays a major role in the pathogenesis of MFS in a mouse model for MFS...
  18. Role of MMPs in TGFbeta-induced Cataract Formation
    Judith A West-Mays; Fiscal Year: 2013
    ..Ultimately, our goal is to define the TGF[unreadable]- mediated pathways controlling EMT and fibrosis in ASC and PCO in order to design therapeutics for mitigating these diseases. ..
  19. Integration of TGFb-ALK5 on Wnt signaling and mechanotransduction in bone
    Damian C Genetos; Fiscal Year: 2013
    ....
  20. GENETICS OF EXTRACELLULAR MATRIX IN HEALTH AND DISEASE
    Zsolt Urban; Fiscal Year: 2013
    ..a downstream effect of different cutis laxa mutations includes dysregulation of transforming growth factor beta (TGFb) signaling...
  21. Cellular and Genetic Determinants of Pharyngeal Arch Artery Specification
    NOELLE NICOLE PAFFETT-LUGASSY; Fiscal Year: 2013
    ..My preliminary data also demonstrate that nkx2.5 and a requisite TGFbeta pathway component, Latent TGFbeta Binding Protein 3 (ltbp3), are required for PAA development, but dispensable ..
  22. TGFbeta signaling, reactive astrogliosis and function after stroke
    Marion S Buckwalter; Fiscal Year: 2013
    ..We propose to ask if Transforming Growth Factor Beta (TGFbeta) signaling in astrocytes modulates inflammation after stroke because it is a master regulator of immune responses...
  23. Annexin A2 as a mediator of pancreatic cancer metastases
    Lei Zheng; Fiscal Year: 2013
    ..and demonstrated that tyrosine 23-phosphorylation-dependent cell-surface translocation of ANXA2 is critical for TGFbeta-Rho mediated epithelia-to-mesenchymal transition, invasion and metastasis of PDAs...
  24. MOLECULAR MECHANISM OF LEIOMYOMA GROWTH AND REGRESSION
    Nasser Chegini; Fiscal Year: 2001
    ..established that leiomyomas and their smooth muscle cells (LSMC) over-express transforming growth factor-beta (TGFBETA), a multifunctional cytokine that controls an array of cellular functions and its overexpression causes tissue ..
  25. MOLECULAR MECHANISM OF LEIOMYOMA GROWTH AND REGRESSION
    Nasser Chegini; Fiscal Year: 2004
    ..established that leiomyomas and their smooth muscle cells (LSMC) over-express transforming growth factor-beta (TGFBETA), a multifunctional cytokine that controls an array of cellular functions and its overexpression causes tissue ..
  26. MOLECULAR MECHANISM OF LEIOMYOMA GROWTH AND REGRESSION
    Nasser Chegini; Fiscal Year: 2002
    ..established that leiomyomas and their smooth muscle cells (LSMC) over-express transforming growth factor-beta (TGFBETA), a multifunctional cytokine that controls an array of cellular functions and its overexpression causes tissue ..
  27. MOLECULAR MECHANISM OF LEIOMYOMA GROWTH AND REGRESSION
    Nasser Chegini; Fiscal Year: 2003
    ..established that leiomyomas and their smooth muscle cells (LSMC) over-express transforming growth factor-beta (TGFBETA), a multifunctional cytokine that controls an array of cellular functions and its overexpression causes tissue ..
  28. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2004
    ..and that these effects are primarily due to the ability of astrocytes to release transforming growth factor-beta (TGFbeta)...
  29. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2003
    ..and that these effects are primarily due to the ability of astrocytes to release transforming growth factor-beta (TGFbeta)...
  30. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2005
    ..and that these effects are primarily due to the ability of astrocytes to release transforming growth factor-beta (TGFbeta)...
  31. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2001
    ..and that these effects are primarily due to the ability of astrocytes to release transforming growth factor-beta (TGFbeta)...
  32. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2002
    ..and that these effects are primarily due to the ability of astrocytes to release transforming growth factor-beta (TGFbeta)...
  33. BREAST CANCER METASTASES TO BONE--ROLE OF PTHRP & TGFB
    Theresa Guise; Fiscal Year: 2000
    ..2) Transforming growth factor-beta (TGFbeta), present in high concentrations in the bone microenvironment, increases secretion of PTHrP by breast and other ..
  34. BREAST CANCER METASTASES TO BONE--ROLE OF PTHRP & TGFB
    Theresa Guise; Fiscal Year: 1999
    ..2) Transforming growth factor-beta (TGFbeta), present in high concentrations in the bone microenvironment, increases secretion of PTHrP by breast and other ..
  35. TGFBM2 in Development and Disease
    Rosemary J Akhurst; Fiscal Year: 2011
    ..Camurati-Engelmann disease and Hereditary Hemorrhagic Telangiectasia, all caused by mutations in individual TGFbeta pathway genes...
  36. TGFBM2 in Development and Disease
    Rosemary Akhurst; Fiscal Year: 2009
    ..Camurati-Engelmann disease and Hereditary Hemorrhagic Telangiectasia, all caused by mutations in individual TGFbeta pathway genes...
  37. TGFBM2 in Development and Disease
    Rosemary J Akhurst; Fiscal Year: 2010
    ..Camurati-Engelmann disease and Hereditary Hemorrhagic Telangiectasia, all caused by mutations in individual TGFbeta pathway genes...
  38. MECHANISMS OF TGF BETA AUTOCRINE REGULATION OF GLIOMAS
    Mark Jennings; Fiscal Year: 1992
    ..Transforming growth factor type-beta (TGFbeta) demonstrates autocrine growth inhibition among the near diploid gliomas, both low-grade and malignant...
  39. HIGH MOLECULAR WEIGHT TRANSFORMING GROWTH FACTOR BETA
    SAMUEL NEWCOM; Fiscal Year: 1990
    ..It has recently been demonstrated that Reed-Sternberg cells from Hodgkin's disease secrete TGFbeta active at physiologic pH...
  40. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2006
    ..our preliminary data suggest a link between decreases in T cell production of transforming growth factor beta (TGFbeta) with autoantibody production, and increases in renal TGFbeta expression with the development of chronic kidney ..
  41. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2004
    ..our preliminary data suggest a link between decreases in T cell production of transforming growth factor beta (TGFbeta) with autoantibody production, and increases in renal TGFbeta expression with the development of chronic kidney ..
  42. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2005
    ..our preliminary data suggest a link between decreases in T cell production of transforming growth factor beta (TGFbeta) with autoantibody production, and increases in renal TGFbeta expression with the development of chronic kidney ..
  43. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2003
    ..our preliminary data suggest a link between decreases in T cell production of transforming growth factor beta (TGFbeta) with autoantibody production, and increases in renal TGFbeta expression with the development of chronic kidney ..
  44. TRANSFORMING GROWTH FACTORS IN NEOPLASTIC TRANSFORMATION
    Harold Moses; Fiscal Year: 1990
    ..Previous studies from this laboratory have demonstrated that (1) transforming growth factor, type Beta (TGFBeta) is a ubiquitous growth regulatory molecule; (2) specific cell membrane receptor for TGFBeta are present on a ..
  45. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2004
    ..The action of TGFbeta may be a critical determinant in the overexpression of PTHrP by carcinomas and play an important role in the ..
  46. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2000
    ..The action of TGFbeta may be a critical determinant in the overexpression of PTHrP by carcinomas and play an important role in the ..
  47. Regulation of TGFBeta-induced apoptosis in liver cells
    Kunxin Luo; Fiscal Year: 2005
    ..The transforming growth factor beta (TGFbeta) signaling pathway is a central component of the mechanisms by which cell growth and apoptosis are regulated in ..
  48. Regulation of TGFBeta-induced apoptosis in liver cells
    Kunxin Luo; Fiscal Year: 2004
    ..The transforming growth factor beta (TGFbeta) signaling pathway is a central component of the mechanisms by which cell growth and apoptosis are regulated in ..
  49. Regulation of TGFBeta-induced apoptosis in liver cells
    Kunxin Luo; Fiscal Year: 2006
    ..The transforming growth factor beta (TGFbeta) signaling pathway is a central component of the mechanisms by which cell growth and apoptosis are regulated in ..
  50. Regulation of TGFBeta-induced apoptosis in liver cells
    Kunxin Luo; Fiscal Year: 2007
    ..The transforming growth factor beta (TGFbeta) signaling pathway is a central component of the mechanisms by which cell growth and apoptosis are regulated in ..
  51. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    Gregory Schultz; Fiscal Year: 2002
    ..In our previous grant, we hypothesized that the TGFbeta system played a dominant role in regulating corneal scarring, and we measured changes in the TGFbeta system ..
  52. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    Gregory Schultz; Fiscal Year: 2003
    ..In our previous grant, we hypothesized that the TGFbeta system played a dominant role in regulating corneal scarring, and we measured changes in the TGFbeta system ..
  53. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    Gregory Schultz; Fiscal Year: 2005
    ..In our previous grant, we hypothesized that the TGFbeta system played a dominant role in regulating corneal scarring, and we measured changes in the TGFbeta system ..
  54. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    Gregory Schultz; Fiscal Year: 2004
    ..In our previous grant, we hypothesized that the TGFbeta system played a dominant role in regulating corneal scarring, and we measured changes in the TGFbeta system ..
  55. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2007
    ..can lead to growth factor activation, including activation of transforming growth factor-alpha (TGFalpha) and TGFbeta. These growth factors, in turn, control proliferation and the transcription of genes involved in differentiated ..
  56. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2006
    ..can lead to growth factor activation, including activation of transforming growth factor-alpha (TGFalpha) and TGFbeta. These growth factors, in turn, control proliferation and the transcription of genes involved in differentiated ..
  57. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    Gregory Schultz; Fiscal Year: 2006
    ..In our previous grant, we hypothesized that the TGFbeta system played a dominant role in regulating corneal scarring, and we measured changes in the TGFbeta system ..
  58. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    Gregory Schultz; Fiscal Year: 2003
    ..In our previous grant, we hypothesized that the TGFbeta system played a dominant role in regulating corneal scarring, and we measured changes in the TGFbeta system ..
  59. Autocrine TGFBeta and Breast Cancer Cell Growth
    Michael Brattain; Fiscal Year: 2002
    ..If the application is funded, this During the present cycle of funding we found that autocrine TGFbeta was induced by vitamin D3 analogs in ER+ breast cancer and pre-malignant mammary epithelial cells...
  60. Autocrine TGFBeta and Breast Cancer Cell Growth
    Michael Brattain; Fiscal Year: 2003
    ..If the application is funded, this During the present cycle of funding we found that autocrine TGFbeta was induced by vitamin D3 analogs in ER+ breast cancer and pre-malignant mammary epithelial cells...
  61. Autocrine TGFBeta and Breast Cancer Cell Growth
    Michael Brattain; Fiscal Year: 2001
    ..If the application is funded, this During the present cycle of funding we found that autocrine TGFbeta was induced by vitamin D3 analogs in ER+ breast cancer and pre-malignant mammary epithelial cells...
  62. Autocrine TGFBeta and Breast Cancer Cell Growth
    Michael Brattain; Fiscal Year: 2005
    ..If the application is funded, this During the present cycle of funding we found that autocrine TGFbeta was induced by vitamin D3 analogs in ER+ breast cancer and pre-malignant mammary epithelial cells...
  63. Autocrine TGFBeta and Breast Cancer Cell Growth
    Michael Brattain; Fiscal Year: 2004
    ..If the application is funded, this During the present cycle of funding we found that autocrine TGFbeta was induced by vitamin D3 analogs in ER+ breast cancer and pre-malignant mammary epithelial cells...
  64. Breast Cancer Osteolysis--Regulation of PTHrP by TGFBeta
    Theresa Guise; Fiscal Year: 2007
    ..b>TGFbeta in the bone microenvironment dramatically changes the phenotype of metastatic tumor cells, causing them to ..
  65. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2001
    ..The action of TGFbeta may be a critical determinant in the overexpression of PTHrP by carcinomas and play an important role in the ..
  66. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2002
    ..The action of TGFbeta may be a critical determinant in the overexpression of PTHrP by carcinomas and play an important role in the ..
  67. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2003
    ..The action of TGFbeta may be a critical determinant in the overexpression of PTHrP by carcinomas and play an important role in the ..
  68. Smurf Ubiquitin Ligases in Xenopus Development
    GERALD THOMSEN; Fiscal Year: 2001
    The TGFbeta superfamily regulates cell growth and differentiation. During Xenopus development, Nodal, Vg1 and activin-related signals induce endoderm and mesoderm, and BMP signals pattern these tissues and regulate ectodermal cell fate...
  69. Smurf Ubiquitin Ligases in Xenopus Development
    GERALD THOMSEN; Fiscal Year: 2003
    The TGFbeta superfamily regulates cell growth and differentiation. During Xenopus development, Nodal, Vg1 and activin-related signals induce endoderm and mesoderm, and BMP signals pattern these tissues and regulate ectodermal cell fate...
  70. Smurf Ubiquitin Ligases in Xenopus Development
    GERALD THOMSEN; Fiscal Year: 2002
    The TGFbeta superfamily regulates cell growth and differentiation. During Xenopus development, Nodal, Vg1 and activin-related signals induce endoderm and mesoderm, and BMP signals pattern these tissues and regulate ectodermal cell fate...