TGF-beta1

Summary

Gene Symbol: TGF-beta1
Description: transforming growth factor, beta 1
Alias: CED, DPD1, LAP, TGFB, TGFbeta, TGF-beta-1, latency-associated peptide, prepro-transforming growth factor beta-1
Species: human

Top Publications

  1. ncbi TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    Kazuhiko Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N238, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 172:834-42. 2004
  2. ncbi Transforming growth factor beta in tissue fibrosis
    W A Border
    Division of Nephrology, University of Utah School of Medicine, Salt Lake City 84132
    N Engl J Med 331:1286-92. 1994
  3. pmc Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    Q Yu
    Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129 USA
    Genes Dev 14:163-76. 2000
  4. doi TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease
    Filippo Caraci
    Department of Pharmaceutical Sciences, University of Catania, Italy
    CNS Neurosci Ther 17:237-49. 2011
  5. pmc Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-β1: role of TGF-β1 in HCV replication
    Lance D Presser
    Department of Microbiology and Immunology, H M Bligh Cancer Research Laboratories, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Virology 412:284-96. 2011
  6. pmc Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    Yasushi Kojima
    Cancer Research UK Stromal Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester M20 4BX, United Kingdom
    Proc Natl Acad Sci U S A 107:20009-14. 2010
  7. ncbi SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
    T Tsukazaki
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 95:779-91. 1998
  8. pmc Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    Shigehiro Doi
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:8655-65. 2011
  9. ncbi Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    S Cheifetz
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 267:19027-30. 1992
  10. ncbi Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex
    Francisco J Blanco
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    J Cell Physiol 204:574-84. 2005

Research Grants

  1. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2005
  2. Smurf Ubiquitin Ligases in Xenopus Development
    GERALD THOMSEN; Fiscal Year: 2005
  3. IN VIVO FUNCTION OF PULMONARY INTEGRINS
    Dean Sheppard; Fiscal Year: 2013
  4. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2011
  5. TGF-regulated EMT
    Philip H Howe; Fiscal Year: 2013
  6. TGFBM2 in Development and Disease
    Rosemary J Akhurst; Fiscal Year: 2012
  7. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
  8. Using Genetics For Early Phenotyping &Prevention of Hypertrophic Cardiomyopathy
    Christine E Seidman; Fiscal Year: 2013
  9. Cardiac Fibrosis Progressive Heart Failure: The Role of Endoglin
    NAVIN KUMAR KAPUR; Fiscal Year: 2013
  10. TGF Beta receptor biology in human renal cell carcinoma
    JOHN COPLAND; Fiscal Year: 2009

Detail Information

Publications362 found, 100 shown here

  1. ncbi TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    Kazuhiko Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N238, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 172:834-42. 2004
    ..these cells do not protect recipient mice from colitis in the SCID transfer model in vivo, and, in addition, CD4+LAP+, but not CD4+LAP- T cells from normal mice protect recipient mice from colitis in this model...
  2. ncbi Transforming growth factor beta in tissue fibrosis
    W A Border
    Division of Nephrology, University of Utah School of Medicine, Salt Lake City 84132
    N Engl J Med 331:1286-92. 1994
  3. pmc Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    Q Yu
    Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129 USA
    Genes Dev 14:163-76. 2000
    ..These observations suggest that coordinated CD44, MMP-9, and TGF-beta function may provide a physiological mechanism of tissue remodeling that can be adopted by malignant cells to promote tumor growth and invasion...
  4. doi TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease
    Filippo Caraci
    Department of Pharmaceutical Sciences, University of Catania, Italy
    CNS Neurosci Ther 17:237-49. 2011
    ..In the present review, we examine the evidence for a neuroprotective role of TGF-β1 in AD, and discuss the TGF-β1 signaling pathway as a new pharmacological target for the treatment of AD...
  5. pmc Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-β1: role of TGF-β1 in HCV replication
    Lance D Presser
    Department of Microbiology and Immunology, H M Bligh Cancer Research Laboratories, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Virology 412:284-96. 2011
    ..Collectively, these observations provide insight into the mechanism of TGF-β1 activation, which likely manifest in liver fibrosis associated with hepatitis C infection...
  6. pmc Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    Yasushi Kojima
    Cancer Research UK Stromal Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester M20 4BX, United Kingdom
    Proc Natl Acad Sci U S A 107:20009-14. 2010
    ..This autocrine-signaling mechanism may prove to be an attractive therapeutic target to block the evolution of tumor-promoting CAFs...
  7. ncbi SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
    T Tsukazaki
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 95:779-91. 1998
    ..SARA functions to recruit Smad2 to the TGFbeta receptor by controlling the subcellular localization of Smad2 and by interacting with the TGFbeta receptor ..
  8. pmc Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    Shigehiro Doi
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:8655-65. 2011
    ..These results have raised the possibility that secreted Klotho may function as an endogenous anti-EMT factor by inhibiting multiple growth factor signaling pathways simultaneously...
  9. ncbi Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    S Cheifetz
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 267:19027-30. 1992
    ..TGF-beta however is binding with high affinity to only a small fraction of the available endoglin molecules, suggesting that some rate-limiting event is required to sustain TGF-beta binding to endoglin...
  10. ncbi Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex
    Francisco J Blanco
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    J Cell Physiol 204:574-84. 2005
    ..By contrast, endoglin appears to interfere with TGF-beta/ALK-5 signaling. These results suggest that the functional association of endoglin with ALK-1 is critical for the endothelial responses to TGF-beta...
  11. ncbi Tumor-derived TGFbeta-1 induces dendritic cell apoptosis in the sentinel lymph node
    Manabu Ito
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 01 8543, Japan
    J Immunol 176:5637-43. 2006
    ..We found that the incidence of apoptosis among DCs was higher in SLNs than in non-SLNs, as were levels of TGFbeta-1...
  12. ncbi TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells
    Naoki Hagimoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 168:6470-8. 2002
    ..Our results demonstrate a novel role of TGF-beta 1 in the pathophysiology of pulmonary fibrosis as an enhancer of Fas-mediated apoptosis of lung epithelial cells...
  13. ncbi TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Stroke 37:2667-71. 2006
    ..We therefore investigated 5 polymorphisms in the TGF-beta1 gene (-800 G/A, -509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study...
  14. ncbi Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins
    N W Morrell
    Department of Medicine, University of Cambridge, Addenbrooke s and Papworth Hospitals, Cambridge, United Kingdom
    Circulation 104:790-5. 2001
    ..We postulated that pulmonary artery smooth muscle cells (PASMCs) from patients with PPH might demonstrate abnormal growth responses to TGF-beta superfamily members...
  15. doi Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
    Ingrid M B H van de Laar
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 43:121-6. 2011
    ..Our findings endorse the TGF-β pathway as the primary pharmacological target for the development of new treatments for aortic aneurysms and osteoarthritis...
  16. doi Transforming growth factor-β 1 enhances the invasiveness of breast cancer cells by inducing a Smad2-dependent epithelial-to-mesenchymal transition
    Zhi Dong Lv
    Department of Breast Surgery, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, PR China
    Oncol Rep 29:219-25. 2013
    ..05). These data suggested that EMT of breast cancer induced by TGF-β1 is dependent on Smad2 signaling and promotes breast cancer cell metastasis...
  17. pmc The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1)
    Zhiqiang Chen
    General Surgery Department of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 287:17016-28. 2012
    ..This study demonstrates that chelators inhibit the TGF-β-induced EMT via a process consistent with NDRG1 up-regulation and elucidates the mechanism of their activity...
  18. doi Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways
    Xiao Feng Chen
    Department of Thoracic Surgury, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China
    Mol Biol Rep 39:3549-56. 2012
    ....
  19. pmc High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells
    Yingze Zhang
    Division of Pulmonary, Allergy and Critical Care Medicine, Richard P and Dorothy P Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e20319. 2011
    ..The objective of this study is to identify genome-wide scale map of SMAD3 binding targets and the molecular pathways and networks affected by the TGFβ1/SMAD3 signaling in lung epithelial cells...
  20. pmc Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts
    Rui Ming Liu
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:16239-47. 2010
    ..Our data suggest that increased generation of ROS by Nox4 mediates TGF-beta1-induced PAI-1 gene expression at least in part through oxidative modification and inhibition of MKP-1 leading to a sustained activation of JNK and p38 MAPKs...
  21. pmc c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3
    Jos L J van der Velden
    Department of Pathology, Health Sciences Research Facility, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 44:571-81. 2011
    ....
  22. ncbi Regulation of TGF-beta signaling by Smad7
    Xiaohua Yan
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Acta Biochim Biophys Sin (Shanghai) 41:263-72. 2009
    ..Overexpression of Smad7 has been shown to antagonize TGF-beta-mediated fibrosis, carcinogenesis, and inflammation, suggesting a therapeutic potential of Smad7 to treat these diseases...
  23. doi Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells
    Jing Wang
    University of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Cancer Res 68:3152-60. 2008
    ..Stable transfection of a dominant-negative transforming growth factor beta (TGFbeta) type II receptor (DNRII) into FET cells that express autocrine TGFbeta shows loss of TGFbeta signaling and ..
  24. pmc NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3
    Saleh Ismail
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah Health Sciences Centerand VA Medical Center, Salt Lake City, Utah 84132, USA
    Am J Physiol Lung Cell Mol Physiol 296:L489-99. 2009
    ..IGFBP-3 increases NOX4 gene expression, resulting in HPASMC proliferation. These observations add to our understanding hypoxic pulmonary vascular remodeling...
  25. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
    ..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors...
  26. pmc TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer
    Shinako Araki
    Department of Oncology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390 8807, USA
    J Clin Invest 120:290-302. 2010
    ..Identification of Hdm2 as a downstream target of TGF-beta1 represents a critical prosurvival mechanism in cancer progression and provides another point for therapeutic intervention in late-stage cancer...
  27. doi Inflammatory cytokine gene variants in coronary artery disease patients in Greece
    Athanassios Manginas
    Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
    Coron Artery Dis 19:575-82. 2008
    ..Abundant evidence supports the central role of inflammatory cytokines in immune responses mediating the pathogenesis of atherosclerosis, coronary artery disease, and its complications, such as myocardial infarction and unstable angina...
  28. ncbi MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration
    Jing Ma
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Blood 109:987-94. 2007
    ..Taken together, our findings suggest that MCP-1 mediates TGF-beta-stimulated angiogenesis by enhancing migration of mural cells toward ECs and thus promoting the maturation of new blood vessels...
  29. ncbi Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells
    Shaoping Xie
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Am J Physiol Lung Cell Mol Physiol 288:L68-76. 2005
    ..TGF-beta 1-stimulated CTGF expression is mediated by mechanisms involving ERK and JNK pathways and is downregulated by IL-4 and IL-13 through modulation of Smad and ERK signals...
  30. pmc Inducible CD4+LAP+Foxp3- regulatory T cells suppress allergic inflammation
    Wei Duan
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 920370, USA
    J Immunol 187:6499-507. 2011
    ..population of CD4(+) T cells in the lungs and lung-draining lymph nodes that express latency-associated peptide (LAP) on their cell surface but do not express Foxp3...
  31. doi HIV increases HCV replication in a TGF-beta1-dependent manner
    Wenyu Lin
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:803-11. 2008
    ..It has remained unclear how HIV, a nonhepatotropic virus, accelerates the progression of liver disease by HCV...
  32. ncbi TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
    R Perlman
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 3:708-14. 2001
    ..Our findings associate Daxx directly with the TGF-beta apoptotic-signalling pathway, and make a biochemical connection between the receptors for TGF-beta and the apoptotic machinery...
  33. pmc The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway
    Jarod Li
    Department of Human Biology, Faculty of Health Sciences, University of Cape Town, 7925 Cape Town, South Africa International Centre for Genetic Engineering and Biotechnology and Division of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, 7925 Cape Town, South Africa Antiviral Gene Therapy Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, Parktown 2193, South Africa
    Mol Biol Cell 24:3569-76. 2013
    ..This study identifies the TGF-β1 signaling pathway as a potentially important player in the regulation of TBX3 in development and cancer. ..
  34. ncbi Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
    Laurence Levy
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cytokine Growth Factor Rev 17:41-58. 2006
    ....
  35. pmc Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor
    Nengwang Yu
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Urology 76:1519.e8-13. 2010
    ..To elucidate the mechanism of transforming growth factor (TGF)-β1 overexpression in prostate cancer cells...
  36. pmc The L10P polymorphism and serum levels of transforming growth factor β1 in human breast cancer
    Eva Taubenschuß
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Int J Mol Sci 14:15376-85. 2013
    ..4 ± 7.4 ng/mL, whereas those of Leu/Leu subjects were 37.6 ± 6.0 ng/mL (p = 0.07). Thus, compared to a previous study of male subjects, we observed only a modest increase, if any, in TGFβ1 levels of female Pro-allele carriers. ..
  37. pmc Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
    Cedric Coulouarn
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 47:2059-67. 2008
    ..Finally, we established that the TGF-beta gene expression signature possessed a predictive value for tumors other than HCC...
  38. pmc The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--β1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells
    Mark D Sides
    Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Respir Cell Mol Biol 44:852-62. 2011
    ..Our in vitro data may help to explain the observation that patients with IPF demonstrating positive staining for LMP1 in lung epithelial cells have a more rapid demise than patients in whom LMP1 is not detected...
  39. pmc Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction
    Soma Meran
    Institute of Nephrology, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 286:17618-30. 2011
    ..In summary, HA facilitates TGF-β1-dependent fibroblast proliferation through promoting interaction between CD44 and EGFR, which then promotes specific MAPK/ERK activation, inducing cellular proliferation...
  40. ncbi The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  41. pmc TGF-β1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells
    S B Pakala
    Department of Biochemistry and Molecular Biology and Institute of Coregulator Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Oncogene 30:2230-41. 2011
    ....
  42. pmc Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells
    Irina Kolosova
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 226:1248-54. 2011
    ..Both Smad2/3 and p38 MAPK had a role in regulation of TGF-β1-induced collagen expression. Furthermore, these data demonstrate that Smads and p38 MAPK differentially regulate EMT-related changes in pulmonary epithelial cells...
  43. pmc Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis
    Cam T Ha
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Biol Reprod 83:27-35. 2010
    ....
  44. doi Relationship between CCL5 and transforming growth factor-β1 (TGFβ1) in breast cancer
    M C Hartmann
    Division of Surgery, School of Medicine, National University of Ireland Galway, Ireland
    Eur J Cancer 47:1669-75. 2011
    ..Hormonal control of CCL5, and a potential relationship with TGFβ1, was also investigated...
  45. ncbi Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-beta1
    Takayuki Naito
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima City 734 8551, Japan
    Am J Physiol Renal Physiol 286:F278-87. 2004
    ..In conclusion, this study has demonstrated that ANG II-induced activation of latent TGF-beta1 in HMC operates via TSP-1. Furthermore, ANG II-induced TSP-1 production is dependent on p38 MAPK and JNK signaling...
  46. ncbi Potentiation of HIV-1 expression in microglial cells by nicotine: involvement of transforming growth factor-beta 1
    R Bryan Rock
    Center for Infectious Diseases and Microbiology Translational Research, Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 3:143-9. 2008
    ..We also found that nicotine robustly altered the gene expression profile of HIV-1-infected microglia and that the transforming growth factor-beta1 is involved in the enhanced expression of HIV-1 by nicotine...
  47. doi The single-molecule mechanics of the latent TGF-β1 complex
    Lara Buscemi
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Curr Biol 21:2046-54. 2011
    ..Together with its latency-associated peptide (LAP), TGF-β1 binds to the latent TGF-β1-binding protein-1 (LTBP-1), which is part of the extracellular matrix (ECM)...
  48. pmc MiR-23a regulates TGF-β-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells
    Mengru Cao
    Department of Internal Medicine, Division of Pulmonary Medicine Infection and Oncology, Nippon Medical School, Tokyo 113 8603, Japan
    Int J Oncol 41:869-75. 2012
    ..These findings suggest that miR-23a regulates TGF-β-induced EMT by targeting E-cadherin in lung cancer cells and may be useful as a new therapeutic target in NSCLC...
  49. ncbi Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome
    Enid R Neptune
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 33:407-11. 2003
    ..These data indicate that matrix sequestration of cytokines is crucial to their regulated activation and signaling and that perturbation of this function can contribute to the pathogenesis of disease...
  50. pmc Snail involves in the transforming growth factor β1-mediated epithelial-mesenchymal transition of retinal pigment epithelial cells
    Hui Li
    Department of Ophthalmology, Shanghai First People s Hospital, Affiliate of Shanghai Jiaotong University, Shanghai, China
    PLoS ONE 6:e23322. 2011
    ..However, the function of Snail in RPE cells undergoing EMT is largely unknown...
  51. doi WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity
    György Szláma
    Institute of Enzymology, Budapest, Hungary
    FEBS J 277:5040-50. 2010
    ..It is suggested that the physical association of WFIKKN proteins with these growth factors may localize their action and thus help to establish growth factor gradients in the extracellular space...
  52. pmc Early defect of transforming growth factor β1 formation in Huntington's disease
    Giuseppe Battaglia
    Neuropharmacology Unit, IRCCS Neuromed, Pozzilli, Italy
    J Cell Mol Med 15:555-71. 2011
    ....
  53. ncbi TGFbeta1 allele association with asthma severity
    L J Pulleyn
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Hum Genet 109:623-7. 2001
    ..In this study, we show that the -509T variant on haplotype 1 is the most informative marker of the TGFbeta1 contribution to asthma severity...
  54. ncbi The gene encoding transforming growth factor beta 1 confers risk of ischemic stroke and vascular dementia
    Younyoung Kim
    Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang, Kyonggi do 431 060, South Korea
    Stroke 37:2843-5. 2006
    ..We investigated the association of the polymorphism in TGFB1 with ischemic stroke and vascular dementia...
  55. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
    Fibrosis is characterized by elevated transforming growth factor beta (TGFbeta) signaling, resulting in extracellular matrix accumulation and increased PAI-1 (plasminogen activator inhibitor) expression...
  56. doi Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway
    Young A Yoo
    Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea University, Seoul 136 705, Korea
    Carcinogenesis 29:480-90. 2008
    ..Additionally, our findings are the first to suggest a role and mechanism for Shh signaling as it relates to the metastatic potential of gastric cancer, thereby indicating potential therapeutic molecular targets to decrease metastasis...
  57. ncbi TGFbeta and Wnt pathway cross-talk
    Liliana Attisano
    Department of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Cancer Metastasis Rev 23:53-61. 2004
    Transforming growth factor-betas (TGFbeta) and Wnts represent two distinct families of secreted molecules each of which utilizes different signaling pathways to elicit their biological effects...
  58. ncbi TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins
    Rachel Anna Evans
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Exp Cell Res 282:90-100. 2003
    ..The study suggests that the phenotypic and functional changes associated with TGF-beta1-induced fibroblast terminal differentiation are differentially regulated by Smad proteins...
  59. pmc GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells
    Dat Q Tran
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13445-50. 2009
    ..This latent complex can associate with latent TGFbeta-binding protein (LTBP) to produce a large latent form...
  60. pmc Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 119:1571-82. 2009
    ..Together, the results suggest that assessment of TGF-beta signaling pathway status may further stratify the prognosis of ER-positive patients and provide novel therapeutic approaches in the management of breast cancer...
  61. pmc Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation
    Y Bian
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, Bethesda, MD, USA
    Oncogene 31:3322-32. 2012
    ....
  62. ncbi Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples
    C N Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Int J Radiat Biol 82:577-86. 2006
    ..The present study was conducted to seek a confirmation of these findings...
  63. ncbi Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
    Sylviane Dennler
    INSERM U697, Hopital Saint Louis, Pavillon Bazin, 1 avenue Claude Vellefaux, 75010 Paris, France
    Cancer Res 67:6981-6. 2007
    ..We thus identify TGF-beta as a potent transcriptional inducer of Gli transcription factors. Targeting the cooperation of Hh and TGF-beta signaling may provide new therapeutic opportunities for cancer treatment...
  64. ncbi Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers
    E B Jude
    Department of Medicine and Diabetes, Manchester Royal Infirmary and School of Biological Sciences, University of Manchester, Manchester, UK
    Diabet Med 19:440-7. 2002
    ..We also compared the TGF-betas with those of chronic venous ulcers...
  65. ncbi Latent transforming growth factor-beta: structural features and mechanisms of activation
    J S Munger
    Department of Cell Biology, New York University, New York, USA
    Kidney Int 51:1376-82. 1997
    ..TGF-beta s are secreted in a latent form due to noncovalent association with latency associated peptide (LAP), which is a homodimer formed from the propeptide region of TGF-beta...
  66. pmc A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity
    Jennifer L Sargent
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Invest Dermatol 130:694-705. 2010
    ..Since transforming growth factor-beta (TGFbeta) has been implicated in driving fibrosis in systemic sclerosis, a mechanism-derived gene expression signature was ..
  67. pmc The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas
    Andrej Valkov
    Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
    PLoS ONE 6:e17507. 2011
    ..We aimed to investigate the prognostic impact of TGF-β1, NF-κB p105, PKC-ζ, Par-6α, E-cadherin and vimentin in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STSs)...
  68. ncbi Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer
    Sambasivarao Damaraju
    Cross Cancer Institute, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 12:2545-54. 2006
    ....
  69. ncbi Transforming growth factor-beta and the immune response to malignant disease
    Beverly A Teicher
    Genzyme Corporation, Framingham, Massachusetts 01701 9322, USA
    Clin Cancer Res 13:6247-51. 2007
    ..Phase I clinical trials of an inhibitor of TGF-beta receptor type I kinase activity and a TGF-beta neutralizing antibody are under way...
  70. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  71. pmc HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
    Sylvie Thuault
    Ludwig Institute for Cancer Research, Box 595 Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 283:33437-46. 2008
    ..The data propose that HMGA2 acts in a gene-specific manner to orchestrate the transcriptional network necessary for the EMT program...
  72. ncbi TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients
    S V V Kalyana Chakravarthi
    Kallam Anji Reddy Molecular Genetics Laboratory, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 46:121-5. 2005
    ..To identify mutations in the TGFBI gene in Indian patients with lattice corneal dystrophy (LCD) or granular corneal dystrophy (GCD) and to look for genotype-phenotype correlations...
  73. ncbi SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 91:915-25. 2004
    ..That SPARC is directly involved in the regulation of the TGF-beta1 signaling cascade is consistent with the paradigm that matricellular proteins modulate interactions among cells, growth factors, and their respective receptors...
  74. ncbi Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
    K A Lewis
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 404:411-4. 2000
    ..The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as co-receptors modulating ligand-receptor sensitivity, selectivity and function...
  75. pmc ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells
    Mei Zhang
    Institute of Nephrology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN UK
    Am J Pathol 169:1282-93. 2006
    ..Furthermore these pathways regulate distinct transcriptional and translational components of TGF-beta1 synthesis...
  76. doi Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity
    Oliver Zschenker
    Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Radiother Oncol 97:26-32. 2010
    ..To examine the association of polymorphisms in ATM (codon 158), GSTP1 (codon 105), SOD2 (codon 16), TGFB1 (position -509), XPD (codon 751), and XRCC1 (codon 399) with fibrosis and also individual radiosensitivity...
  77. doi Transforming growth factor-β1 promotes lung adenocarcinoma invasion and metastasis by epithelial-to-mesenchymal transition
    Hui Jun Zhang
    Tenth People Hospital of Tongji University, Shanghai, China
    Mol Cell Biochem 355:309-14. 2011
    ..More importantly, cell motility and invasion were also enhanced in the EMT process. These results indicated that TGF-β1 may promote lung adenocarcinoma invasion and metastasis via the mechanism of EMT...
  78. doi Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth
    Serif Senturk
    BilGen Research Center and Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
    Hepatology 52:966-74. 2010
    ..In contrast, the deletion of TGF-beta receptor 2 abolished in vitro senescence response and greatly accelerated in vivo tumor growth...
  79. ncbi The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    J S Munger
    Department of Medicine, and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6402, USA
    Cell 96:319-28. 1999
    ..We show that TGF beta 1 LAP is a ligand for the integrin alpha v beta 6 and that alpha v beta 6-expressing cells induce spatially ..
  80. pmc Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition
    Thuy Vy Do
    Northwestern University, 2205 Tech Drive, Hogan 4 150, Evanston, IL 60208, USA
    Mol Cancer Res 6:695-705. 2008
    ..0057). Collectively, these results implicate an important role for the TGF-beta/Smad3 pathway in mediating ovarian oncogenesis by enhancing metastatic potential...
  81. ncbi TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage
    Anna Dubrovska
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, SE 751 24 Uppsala, Sweden
    Oncogene 24:2289-97. 2005
    ..Transforming growth factor-beta (TGFbeta) is a potent regulator of growth, apoptosis and invasiveness of tumor cells, including breast cancer cells...
  82. ncbi Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Bone Miner Res 13:1569-76. 1998
    ..Thus, analysis of the TGF-beta1 genotype may be useful in the prevention and management of osteoporosis...
  83. ncbi Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae
    Juan F Santibanez
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, Madrid, Spain
    Cardiovasc Res 77:791-9. 2008
    ..The aim of this work was to assess the location of ALK1 in endothelial caveolae as well as to study the role of caveolin-1 on the TGF-beta/ALK1 signalling pathway...
  84. pmc Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro
    Kimberly A Brown
    Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Breast Cancer Res 6:R215-31. 2004
    ..Although there is growing interest in TGF-beta1-mediated EMT, the phenotype is limited to only a few murine cell lines and mouse models...
  85. ncbi Transforming growth factor-beta 1 gene polymorphisms and cardiovascular disease in hemodialysis patients
    Madhumathi Rao
    Division of Nephrology and Division of Biostatistics and Clinical Care Research, Tufts New England Medical Center, Boston, Massachusetts, USA
    Kidney Int 66:419-27. 2004
    ....
  86. pmc Mutant surfactant A2 proteins associated with familial pulmonary fibrosis and lung cancer induce TGF-β1 secretion
    Meenakshi Maitra
    Eugene McDermott Center for Human Growth and Development, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75229, USA
    Proc Natl Acad Sci U S A 109:21064-9. 2012
    ..Because secretion of latent TGF-β1 is induced specifically by mutant SP-A2 proteins, therapeutics targeted to block this pathway may be especially beneficial for this molecularly defined subgroup of patients...
  87. ncbi Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway
    Byung Hoon Lee
    Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9041, USA
    J Biol Chem 282:17985-96. 2007
    ..In addition, TGFbeta-induced target gene transcripts were increased in WNK1 small interfering RNA cells...
  88. pmc VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis
    Giovanni Ferrari
    The Seymour Cohn Cardiovascular Research Laboratory, Department of Cardiothoracic Surgery, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 103:17260-5. 2006
    ..This finding illustrates an unexpected role of VEGF and indicates that VEGF can be pharmacologically converted into an apoptotic factor, a novel approach to antiangiogenesis therapy...
  89. doi Cytokine gene polymorphisms in preeclampsia and eclampsia
    Telmo H Barbosa de Lima
    Department of Obstetrics and Gynecology Alagoas State University, Alagoas, Brazil
    Hypertens Res 32:565-9. 2009
    ....
  90. ncbi TGF beta signals through a heteromeric protein kinase receptor complex
    J L Wrana
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 71:1003-14. 1992
    ..This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors...
  91. pmc Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
    Suping Zhang
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Mol Cell Biol 27:4488-99. 2007
    ..Finally, we provide evidence that Smad7 disrupts the formation of the TGF-beta-induced functional Smad-DNA complex. Our findings suggest that Smad7 inhibits TGF-beta signaling in the nucleus by a novel mechanism...
  92. pmc Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni
    Brian B Graham
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine B B G, J C, L G, J P, E D, L D, T T, L S, N D, R W V and Department of Pathology X J W, Anschutz Medical Campus, Aurora, CO Pulmonary Vascular Research Institute B B G, A B, H C C, G B, R M T Memorial S Jose Hospital, Universidade de Pernambuco in Recife, Recife, Brazil A B Division of Cardiology, University of Pittsburgh, Pittsburgh, PA H C C School of Pharmacy, University of Kent, Kent, UK G B and Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD T A W
    Circulation 128:1354-64. 2013
    ..We hypothesized that transforming growth factor-β (TGF-β) signaling as a consequence of Th2 inflammation is critical for the pathogenesis of this disease...
  93. doi Interaction between TGF-β1 (869C/T) polymorphism and biochemical risk factor for prediction of disease progression in rheumatoid arthritis
    Yousri M Hussein
    Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt Medical Laboratory Department, Faculty of Applied Medical Science, Taif University, Saudi Arabia
    Gene 536:393-7. 2014
    ..We aimed to determine whether TGF-β1 polymorphism is associated with susceptibility to RA and progression of joint destruction, as well as to identify the interaction between TGF-β1 polymorphism and biochemical risk factor...
  94. ncbi SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells
    Shigeo Matsuyama
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Res 63:7791-8. 2003
    ....
  95. pmc TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
    Charalambos Michaeloudes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 300:L295-304. 2011
    ..Knockdown of Nox4 using small interfering RNA partially prevented the inhibition of MnSOD but had no effect on catalase and IL-6 expression. These findings provide novel insights into redox regulation of ASM function by TGF-β...
  96. pmc Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism
    Fen Guo
    Department of Dentistry, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 6:e19756. 2011
    ....
  97. doi No association between TGF-β1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients
    An M Voets
    Maastricht University, The Netherlands
    Radiother Oncol 105:296-8. 2012
    ..We were not able to confirm the reported association, neither using maximum dyspnea score nor after correction for baseline dyspnea score...
  98. ncbi Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells
    Yasuyuki Hirashima
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka 431 3192, Japan
    J Biol Chem 278:26793-802. 2003
    ..This represents a novel pathway by which tumor cells can regulate the plasminogen activator system-dependent cellular responses in mesothelial cells that may contribute to formation of peritoneal dissemination of ovarian cancer...
  99. doi Association of oxidized low-density lipoprotein and transforming growth factor-beta in type 2 diabetic patients: a cross-sectional study
    Manouchehr Nakhjavani
    Endocrinology and Metabolism Research Center EMRC, Vali Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Transl Res 153:86-90. 2009
    ..308, P = 0.007). In conclusion, this study demonstrated that ox-LDL is significantly correlated to TGF-beta in type 2 diabetic patients...
  100. ncbi TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer
    Christian Nicolaj Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Radiother Oncol 75:18-21. 2005
    ..005) as well as the TGFB1 position -509 T allele (P=0.018) and increased risk of altered breast appearance. No significant associations were found for the remaining SNPs...
  101. doi Regulation of TGF-β1 expression by androgen deprivation therapy of prostate cancer
    Paolo Fuzio
    Institute for Biomedical Technologies, Bari, Italy
    Cancer Lett 318:135-44. 2012
    ....

Research Grants71

  1. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2005
    ..The action of TGFbeta may be a critical determinant in the overexpression of PTHrP by carcinomas and play an important role in the ..
  2. Smurf Ubiquitin Ligases in Xenopus Development
    GERALD THOMSEN; Fiscal Year: 2005
    The TGFbeta superfamily regulates cell growth and differentiation. During Xenopus development, Nodal, Vg1 and activin-related signals induce endoderm and mesoderm, and BMP signals pattern these tissues and regulate ectodermal cell fate...
  3. IN VIVO FUNCTION OF PULMONARY INTEGRINS
    Dean Sheppard; Fiscal Year: 2013
    ..in vivo significance and molecular mechanisms of integrin-mediated activation of transforming growth factor beta (TGFbeta)...
  4. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2011
    ..Transforming growth factor beta (TGFbeta) is a principal stimulator of fibrogenesis...
  5. TGF-regulated EMT
    Philip H Howe; Fiscal Year: 2013
    ..We identified that heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) binds to a structural, 33-nucleotide TGFbeta-activated translation (BAT) element in the 3'-UTR of two bona fide EMT-inducer transcripts, disabled-2 (Dab2)..
  6. TGFBM2 in Development and Disease
    Rosemary J Akhurst; Fiscal Year: 2012
    ..Camurati-Engelmann disease and Hereditary Hemorrhagic Telangiectasia, all caused by mutations in individual TGFbeta pathway genes...
  7. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
    ....
  8. Using Genetics For Early Phenotyping &Prevention of Hypertrophic Cardiomyopathy
    Christine E Seidman; Fiscal Year: 2013
    ..Molecular network analysis in mouse models of HCM identified a central role for transforming growth factor-beta (TGFb) activation in myocardial fibrogenesis...
  9. Cardiac Fibrosis Progressive Heart Failure: The Role of Endoglin
    NAVIN KUMAR KAPUR; Fiscal Year: 2013
    ..This program will elucidate the role of endoglin, a co-receptor for the cytokine transforming growth factor-beta (TGFb), in cardiac fibrosis. Michael E...
  10. TGF Beta receptor biology in human renal cell carcinoma
    JOHN COPLAND; Fiscal Year: 2009
    ..of conventional RCC patient matched specimens, we identified aberrations in the transforming growth factor beta (TGFbeta) pathway. We observed loss of type III TGFbeta receptor (TbetaR3) in all samples...
  11. TGFbeta-PTEN Interactions in Glioma Biology & Therapy
    Jeremy N Rich; Fiscal Year: 2010
    ..Any promising new therapies can be directly translated into clinical trials at the Preston Robert Tisch Brain Tumor Center. ..
  12. LIGAND BINDING DOMAINS OF TGF BETA RECEPTOR
    ANDRZEJ KREZEL; Fiscal Year: 2000
    ..application's objective is the structural explanation of the specificity of the transforming growth factor beta (TGFbeta) binding to the TGFbeta receptors (TbetaR)...
  13. MCP5 as key mediator of TGFbeta signaling in joint maintenance and osteoarthritis
    Lara Longobardi; Fiscal Year: 2013
    ..Our studies will provide critical insights on joint development homeostasis and OA pathophysiology. ..
  14. Aspergillus-specific CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2010
    ..fumigatus spores, 2) to establish the role of the regulatory cytokines IL-10 and TGFbeta in this process, 3) to examine the influence of concurrent innate inflammatory responses on T cell activation and ..
  15. METABOLISM OF THE TRABECULAR MESHWORK
    David L Epstein; Fiscal Year: 2011
    ..Relevance: This project has the potential to increase our understanding of both normal and abnormal outflow pathway function and to lead to new treatments for glaucoma. ..
  16. The Role of Lumican in the cornea
    Shukti Chakravarti; Fiscal Year: 2012
    ..Thus, innate immune response is impaired in our Lum-/- mice. Lumican also binds FasL and TGFbeta, and in the Lum-/- mice these pathways are disrupted...
  17. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz-Martin; Fiscal Year: 2012
    ..is needed for tumor suppression and cell survival mediated by important gene regulators p53, NFB, STAT and Smad/TGFbeta), providing the first evidence for how Piasy is regulated in cells...
  18. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2012
    ..two growth factors that are the major regulators of scar formation in the cornea, transforming growth factor beta (TGFb), and its downstream mediator, connective tissue growth factor (CTGF)...
  19. SnoN and TGFbeta Signaling
    Kunxin Luo; Fiscal Year: 2013
    ..These studies will allow us to understand the function of SnoN in normal mammalian cells and how deregulation of these activities facilitates tumorigenesis. ..
  20. Hepatocyte Nox proteins in the pathogenesis of hepatocellular carcinoma
    Jinah Choi; Fiscal Year: 2013
    ..Results from this study will increase our understanding of hepatocyte Nox4 and the role of inflammation in cancer, for the development of therapy. ..
  21. Role of TGFbeta signaling in HNSCC progression
    Xiao Jing Wang; Fiscal Year: 2013
    ..The proposed studies will lead to the identification of biomarkers that can be used to improve cancer prognosis and therapy. ..
  22. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    ..We will assess the impact of delivery of let-7g pre-miRNA on HDM-induced remodeling. ..
  23. TGFBeta Receptor Mutations in Cancer and Other Diseases
    Edmund C Lattime; Fiscal Year: 2012
    ....
  24. Molecular Biology of Marfan Syndrome
    Harry C Dietz; Fiscal Year: 2013
    ..Many manifestations of MFS, including aortic aneurysm and tear, are driven by excessive TGFbeta signaling, particularly the noncanonical ERK cascade, and can be attenuated by TGFbeta blocking agents in mouse ..
  25. Mesenchymal Cell Fate Determination by Extracellular Matrix Stiffness
    Jeffrey C Horowitz; Fiscal Year: 2013
    ....
  26. Cell Specific Responses to TNF-alpha in Lung Fibrosis
    Gloria Pryhuber; Fiscal Year: 2009
    ..Direct analysis of proteins currently identified as modulators of pulmonary fibrosis, including TGFbeta and MIP2, will be performed in these novel, chimeric models of silica-sensitive and -resistant lung...
  27. TGFb Modulation: Therapeutic Targeting for COPD-Emphysema
    Enid R Neptune; Fiscal Year: 2012
    ..In Aim 2, we will test a small molecule antagonist of TGFb signaling that specifically inhibits the type I TGFbeta receptor (Alk5) for preclinical efficacy in an established animal model of CS induced emphysema...
  28. Targeted delivery of TGFbeta blockade to diseased glomeruli
    Yufeng Huang; Fiscal Year: 2010
    ....
  29. The Role of Plexin C1 in Scleroderma Related Interstitial Lung Disease
    Aditi Mathur; Fiscal Year: 2013
    ..If successful, these studies could lead to novel insights into the immunopathogenesis of pulmonary fibrosis that might one day allow Plexin C1-based therapeutics. ..
  30. Role of TGFbeta superfamily in Broncopulmonary Dysplasia
    SIMON JAMES CONWAY; Fiscal Year: 2013
    ..Aim 3 will determine the mechanism(s) by which absence of the downstream TGF-[unreadable]2 effector ECM protein, [unreadable]igH3, is sufficient to cause BPD. ..
  31. Mechanism of LTBP4 in muscular dystrophy
    Ermelinda Ceco; Fiscal Year: 2012
    ..Work by others has shown that enhanced TGFBeta signaling in skeletal muscle contributes to impaired regeneration in muscle, however the molecular mechanism ..
  32. Targeting epithelial cells to treat pulmonary fibrosis
    Dean Sheppard; Fiscal Year: 2013
    ..is a consequence of n-going epithelial stress and apoptosis, which leads to activation of extracellular latent TGFbeta by the alpha nu beta integrin on alveolar epithelial cells, which in turn induces progressive fibrosis at least ..
  33. Body size control genes & TGF-beta signaling C. elegans
    Cathy Savage Dunn; Fiscal Year: 2009
    EXCEED THE SPACE PROVIDED. Transforming growth factor beta (TGFbeta) related ligands regulate many aspects of cell differentiation and function, and components of the signaling pathway act as tumor suppressors involved in human cancers...
  34. MECHANISMS OF BPD PATHOGENESIS
    PARVIZ MINOO MINOO; Fiscal Year: 2013
    ..We have shown that bioactive TGFbeta in the lungs of human preterm infants predicts severity of BPD, suggesting a possible role in its pathogenesis ..
  35. Role of MMPs in TGFbeta-induced Cataract Formation
    Judith A West-Mays; Fiscal Year: 2013
    ..Ultimately, our goal is to define the TGF[unreadable]- mediated pathways controlling EMT and fibrosis in ASC and PCO in order to design therapeutics for mitigating these diseases. ..
  36. Regulation of TGF-Beta Activity in the Lung by LTBP-4
    Daniel B Rifkin; Fiscal Year: 2013
    ..part of a tripartite latent complex that includes, in addition to TGF-[unreadable], the latency associated protein (LAP) and latent TGF-[unreadable] binding protein (LTBP), which is disulfide bonded to LAP...
  37. uPA/uPAR and Ro60 in the pathogenesis of congenital heart block
    PARASKEVI BRIASOULI; Fiscal Year: 2013
    ..Daniel Rifkin, an expert in TGFbeta, Dr. Thomas Neubert, an expert in mass spectrometry, and Dr. Tom Gordon, an expert in Ro60 and apoptosis...
  38. Structural basis of antagonism within the TGFbeta-superfamily
    Thomas B Thompson; Fiscal Year: 2012
    ..Our research is significant as it is expected to provide details of binding molecules that antagonize ligands. This information will strengthen efforts to customize therapies designed to neutralize TGF[unreadable]-family ligands. ..
  39. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..In 2006, we showed that excessive TGFbeta signaling plays a major role in the pathogenesis of MFS in a mouse model for MFS...
  40. GROWTH CONTROL OF NORMAL AND CIRRHOTIC HEPATOCYTES
    Kevin E Behrns; Fiscal Year: 2010
    ..hepatocytes exhibited markedly decreased apoptosis after treatment with transforming growth factor beta (TGFbeta), tumor necrosis factor alpha (TNFalpha), and ultraviolet radiation...
  41. Individual Predoctoral Dental Scientist Fellowship
    Angela Gullard; Fiscal Year: 2013
    ..expression in the dentin layer and in pulp cells of a novel transgenic mouse model for Camurati-Engelmann disease (CED)...
  42. Cellular Senescence and Glaucoma
    Pedro Gonzalez; Fiscal Year: 2011
    ....
  43. Systems analysis of TGFbeta signaling and SnoN function in liver
    Kunxin Luo; Fiscal Year: 2013
    ..The long-term goal of this project is to understand how proper levels of TGF2 signaling activity are maintained and regulated in normal tissues and primary cells using a system biology approach. ..
  44. Regulation of Periostin by TGFbeta and BMP in Heart Development
    Thomas Doetschman; Fiscal Year: 2010
    ..These proposed studies will largely focus on determining what role the secreted extracellular matrix protein Periostin (POSTN) plays during valve matrix remodeling;and the part that TGF2 and BMP signaling plays in regulating POSTN. ..
  45. COX GENE REGULATION IN INTESTINAL MYOFIBROBLASTS
    Don Powell; Fiscal Year: 2009
    ..signaling pathways mediate COX-2 mRNA stabilization in isolated IMFs, 3) Identify the mechanisms by which TGFbeta induces COX-2 expression in isolated IMFs and 4) Investigate and clarify how ROS and TGFbeta influence ..
  46. Control of Colonic Inflammation and Tumor Growth by TGFBeta and Dietary Vitamin D
    Lillian Maggio-Price; Fiscal Year: 2012
    ..dietary vitamin D on the incidence of bacterial- induced IBD and colon cancer in a mouse model with defective TGFb signaling, as well as the ability of supplemental vitamin D to protect against disease...
  47. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Frank A Middleton; Fiscal Year: 2013
    ..the effects of ethanol on the cycling activity (cell cycle kinetics and exit) and on the expression/activation of TGFbeta receptors by neural stem cells in the cortical proliferative zones...
  48. Improved Drug Delivery to Tumors Using Novel Tissue Perfusion Approaches
    HEIKE ELIZABETH DALDRUP-LINK; Fiscal Year: 2012
    ..abstract_text> ..
  49. Molecular Mechanisms of the Increased Cardiovascular Risk in Rheumatoid Arthritis
    MARIO CESAR RICO; Fiscal Year: 2013
    ..The alpha granules of platelets contain thrombospondin-1 (TSP1) and transforming growth factor beta (TGFb), which are anti-angiogenic and anti-inflammatory molecules, respectively...
  50. TGF-BETA REGULATION OF INTESTINAL EPITHELIAL CELLS
    John Barnard; Fiscal Year: 2009
    ..Over the past decade, we have studied the autocrine growth inhibitory factor, transforming growth factor beta(TGFbeta), in normal and aberrant intestinal epithelial growth...
  51. Effect of PPAR?? Ligands on Alcohol-Induced Alveolar Macrophage Dysfunction
    Samantha M Yeligar; Fiscal Year: 2011
    ....
  52. Mechanisms of Renal Protection with Volatile Anesthetics
    H Thomas Lee; Fiscal Year: 2013
    ..As such, our proposal may identify novel therapeutic targets (e.g., IL-11) and novel therapeutics (polyethylene glycol-conjugated IL-11) to reduce complications of AKI and lead to a radical reduction in mortality and morbidity. ..
  53. TGF-beta polymorphisms and breast cancer in families
    Boris Pasche; Fiscal Year: 2013
    ..This project will study 65 genes of the TGF-2 pathway in 5357 women with breast cancer and their unaffected sisters and determine which genes are associated with breast cancer risk. ..
  54. TGFbeta IN THE BONE MICROENVIRONMENT: ROLE IN TUMOR METASTASIS
    Theresa A Guise; Fiscal Year: 2012
    ..osteoblastic bone metastases. Imaging of tumor in bone permits direct validation in vivo of mechanisms that are inaccessible by other means. ..
  55. Mechanisms Underlying Treatment-Resistant Depression and Anxiety in Mouse Models
    Benjamin A Samuels; Fiscal Year: 2013
    ..The immediate goals for this proposal are to define the importance of a signaling pathway (TGFbeta), which fails to be activated in animal models of treatment-resistant depression and anxiety, in mediating the ..
  56. Integrin-mediated Regulation of TGFbeta Signaling and Tumorigenesis
    WILLIAM SCHIEMANN; Fiscal Year: 2013
    ..Moreover, translating our epigenetic biomarkers to clinical diagnostic applications will enable science and medicine to significantly improve the overall survival of patients with TNBCs. ..
  57. Vitamin D3 Supplementation for Low-Risk Prostate Cancer: A Randomized Trial
    Sebastiano Gattoni-Celli; Fiscal Year: 2013
    ..techniques the expression of the following biomarkers: vitamin D receptor (VDR), p21, tumor growth factor beta (TGFbeta), cyclooxygenase 2 (COX- 2), and NFkappaB...
  58. TGFbeta signaling in neurodegeneration and Alzhimer's
    Tony Wyss Coray; Fiscal Year: 2010
    ..These in vivo studies will help us to assess the relevance and potential therapeutic implications of our hypothesis and will evaluate the TGF-bet1 signaling pathway as a potential target for the treatment of Alzheimer's disease. ..
  59. Role of alpha6beta4 integrin in epidermal carcinogenesis
    David M Owens; Fiscal Year: 2010
    ..predisposes the epidermis to form chemically-induced tumors and perturbs transforming growth factor beta (TGFbeta) signaling in basal cells via a mechanism that requires E-cadherin-mediated intercellular adhesion and PI 3-..
  60. Perinatal regulation of TGF-beta1 during vascular remodeling
    Stephen M Black; Fiscal Year: 2010
    ..The information garnered from these studies will elucidate the mechanisms by which biomechanical forces regulate the TGF-b1/VEGF axis and should prove to be significant in developing new treatment strategies for children with CHD. ..
  61. Interactions between TGFbeta and retinoid signaling in cardiac development
    Loretta L Hoover; Fiscal Year: 2010
    ..These data suggest that the retinoid and TGFB pathways intersect to regulate cardiac development and preliminary studies support the potential for direct ..
  62. Mouse models of neuroprotection in dopamine neurons
    Eric J Huang; Fiscal Year: 2013
    ..The research plans proposed for this award are built on recent findings that TGFbeta and its downstream signaling kinase HIPK2 support the survival of midbrain DA neurons...
  63. Genetic Determinants of Secondary Heart Field Development
    Kathleen Nevis; Fiscal Year: 2013
    ..Unpublished data from our lab demonstrates that the SHF is evolutionarily conserved in zebrafish and marked by the TGFb signaling component Latent Transforming Growth Factor Beta Binding Protein 3 (LTBP3)...
  64. REGULATION OF NEUROTRANSMITTER METABOLISM
    John A Kessler; Fiscal Year: 2013
    ..BMPRIb) and type II (BMPRII) receptor subunits that are organized with minor modifications of the prototypical TGFbeta subclass...
  65. Integration of TGFb-ALK5 on Wnt signaling and mechanotransduction in bone
    Damian C Genetos; Fiscal Year: 2013
    ....
  66. Cellular and Genetic Determinants of Pharyngeal Arch Artery Specification
    NOELLE NICOLE PAFFETT-LUGASSY; Fiscal Year: 2013
    ..My preliminary data also demonstrate that nkx2.5 and a requisite TGFbeta pathway component, Latent TGFbeta Binding Protein 3 (ltbp3), are required for PAA development, but dispensable ..
  67. Annexin A2 as a mediator of pancreatic cancer metastases
    Lei Zheng; Fiscal Year: 2013
    ..and demonstrated that tyrosine 23-phosphorylation-dependent cell-surface translocation of ANXA2 is critical for TGFbeta-Rho mediated epithelia-to-mesenchymal transition, invasion and metastasis of PDAs...
  68. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2005
    ..and that these effects are primarily due to the ability of astrocytes to release transforming growth factor-beta (TGFbeta)...
  69. BREAST CANCER METASTASES TO BONE--ROLE OF PTHRP & TGFB
    Theresa Guise; Fiscal Year: 2000
    ..2) Transforming growth factor-beta (TGFbeta), present in high concentrations in the bone microenvironment, increases secretion of PTHrP by breast and other ..
  70. HIGH MOLECULAR WEIGHT TRANSFORMING GROWTH FACTOR BETA
    SAMUEL NEWCOM; Fiscal Year: 1992
    ..It has recently been demonstrated that Reed-Sternberg cells from Hodgkin's disease secrete TGFbeta active at physiologic pH...
  71. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2006
    ..our preliminary data suggest a link between decreases in T cell production of transforming growth factor beta (TGFbeta) with autoantibody production, and increases in renal TGFbeta expression with the development of chronic kidney ..