Gene Symbol: TGF-beta1
Description: transforming growth factor beta 1
Alias: CED, DPD1, LAP, TGFB, TGFbeta, transforming growth factor beta-1, TGF-beta-1, latency-associated peptide, prepro-transforming growth factor beta-1
Species: human
Products:     TGF-beta1

Top Publications

  1. Wang J, Sergina N, Ko T, Gong J, Brattain M. Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity. J Biol Chem. 2004;279:40237-44 pubmed
    ..a more sensitive effector of the TGF-beta signaling pathway, which can be induced and saturated by autocrine TGF-beta, whereas CDK4 inhibition is a less sensitive effector, which can only be activated by high levels of exogenous TGF-beta ..
  2. Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H, et al. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol. 2004;172:834-42 pubmed
    ..these cells do not protect recipient mice from colitis in the SCID transfer model in vivo, and, in addition, CD4+LAP+, but not CD4+LAP- T cells from normal mice protect recipient mice from colitis in this model...
  3. Crobu F, Palumbo L, Franco E, Bergerone S, Carturan S, Guarrera S, et al. Role of TGF-beta1 haplotypes in the occurrence of myocardial infarction in young Italian patients. BMC Med Genet. 2008;9:13 pubmed publisher
    b>Transforming growth factor beta 1 (TGF-beta1) gene play an important role in the acute myocardial infarction (AMI), however no investigation has been conducted so far in young AMI patients...
  4. Schneider D, Kleeff J, Berberat P, Zhu Z, Korc M, Friess H, et al. Induction and expression of betaig-h3 in pancreatic cancer cells. Biochim Biophys Acta. 2002;1588:1-6 pubmed
  5. Silverman E, Palmer L, Subramaniam V, Hallock A, Mathew S, Vallone J, et al. Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. Am J Respir Crit Care Med. 2004;169:214-9 pubmed
    ..We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription. ..
  6. Hu X. TGFbeta-mediated formation of pRb-E2F complexes in human myeloid leukemia cells. Biochem Biophys Res Commun. 2008;369:277-80 pubmed publisher
    b>TGFbeta is well known for its inhibitory effect on cell cycle G1 checkpoint kinases. However, its role in the control of pRb-E2F complexes is not well established...
  7. Gramley F, Lorenzen J, Koellensperger E, Kettering K, Weiss C, Munzel T. Atrial fibrosis and atrial fibrillation: the role of the TGF-?1 signaling pathway. Int J Cardiol. 2010;143:405-13 pubmed publisher
    ..The sequential changes in the contribution of different profibrotic processes during the establishment of AF may offer the opportunity to selectively interfere with the atrial remodeling process at different stages. ..
  8. Viloria Petit A, David L, Jia J, Erdemir T, Bane A, Pinnaduwage D, et al. A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci U S A. 2009;106:14028-33 pubmed publisher
    ..and an orthotopic mouse model of breast cancer, we reveal that Par6 signaling, which is regulated directly by TGFbeta, plays a role in breast cancer metastasis...
  9. Papageorgis P, Lambert A, Ozturk S, Gao F, Pan H, Manne U, et al. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 2010;70:968-78 pubmed publisher
    ..model system, we found that cells that underwent EMT exhibited overactive transforming growth factor beta (TGFbeta) signaling and loss of expression of the CDH1, CGN, CLDN4, and KLK10 genes as a result of hypermethylation of ..

More Information

Publications421 found, 100 shown here

  1. Guan X, Sturgis E, Lei D, Liu Z, Dahlstrom K, Wei Q, et al. Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer. Clin Cancer Res. 2010;16:1416-22 pubmed publisher
  2. Jian H, Shen X, Liu I, Semenov M, He X, Wang X. Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev. 2006;20:666-74 pubmed
  3. Amini Nik S, Ebrahim R, Van Dam K, Cassiman J, Tejpar S. TGF-beta modulates beta-Catenin stability and signaling in mesenchymal proliferations. Exp Cell Res. 2007;313:2887-95 pubmed
    ..This modulation of beta-Catenin levels by TGF-beta may be involved in determining the tumoral phenotype of the cells. ..
  4. Kaplan D, Li M, Jenison M, Shlomchik W, Flavell R, Shlomchik M. Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med. 2007;204:2545-52 pubmed
    ..Thus, TGFbeta1 derived from LCs acts directly on LCs through an autocrine/paracrine loop, and it is required for LC development and/or survival. ..
  5. Barreto de Souza V, Xavier Medeiros T, Machado Motta M, Bou Habib D, Saraiva E. HIV-1 infection and HIV-1 Tat protein permit the survival and replication of a non-pathogenic trypanosomatid in macrophages through TGF-beta1 production. Microbes Infect. 2008;10:642-9 pubmed publisher
  6. Tang Y, Wu X, Lei W, Pang L, Wan C, Shi Z, et al. TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med. 2009;15:757-65 pubmed publisher
    ..Disturbances of this process are associated with skeletal diseases, such as Camurati-Engelmann disease (CED)...
  7. Alakulppi N, Kyllönen L, Jäntti V, Matinlauri I, Partanen J, Salmela K, et al. Cytokine gene polymorphisms and risks of acute rejection and delayed graft function after kidney transplantation. Transplantation. 2004;78:1422-8 pubmed
    ..6, 95% CI 1.1-2.6, P = 0.040). Our results confirm that cytokine gene polymorphisms influence the outcome of kidney transplantation. Our data especially identify the TNF-alpha -308AA-genotype as a factor predisposing for AR episodes. ..
  8. Panutsopulos D, Papalambros E, Sigala F, Zafiropoulos A, Arvanitis D, Spandidos D. Protein and mRNA expression levels of VEGF-A and TGF-beta1 in different types of human coronary atherosclerotic lesions. Int J Mol Med. 2005;15:603-10 pubmed
  9. Cigna N, Farrokhi Moshai E, Brayer S, Marchal Sommé J, Wemeau Stervinou L, Fabre A, et al. The hedgehog system machinery controls transforming growth factor-?-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis. Am J Pathol. 2012;181:2126-37 pubmed publisher
    ..These data identify the GLI transcription factors as potential therapeutic targets in lung fibrosis. ..
  10. Giannelli G, Bergamini C, Fransvea E, Sgarra C, Antonaci S. Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology. 2005;129:1375-83 pubmed
    ..Our study shows that Ln-5 and TGF-beta1 cooperatively induce EMT in HCC, suggesting the microenvironment as a potential target for new biological therapies. ..
  11. Li G, Heaton J, Gelehrter T. Role of steroid receptor coactivators in glucocorticoid and transforming growth factor beta regulation of plasminogen activator inhibitor gene expression. Mol Endocrinol. 2006;20:1025-34 pubmed
    b>TGFbeta is a major regulator of extracellular matrix deposition and a potent inducer of type-1 plasminogen activator inhibitor (PAI-1) gene expression...
  12. Babel N, Cherepnev G, Babel D, Tropmann A, Hammer M, Volk H, et al. Analysis of tumor necrosis factor-alpha, transforming growth factor-beta, interleukin-10, IL-6, and interferon-gamma gene polymorphisms in patients with chronic periodontitis. J Periodontol. 2006;77:1978-83 pubmed
    ..459; 95% CI = 0.230 to 0.920; P = 0.0421). The -174IL-6 and TGF-beta1 (codon 25) single-nucleotide polymorphisms are associated with susceptibility to chronic periodontitis in the population studied. ..
  13. Thys M, Schrauwen I, Vanderstraeten K, Janssens K, Dieltjens N, Van Den Bogaert K, et al. The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populations. Hum Mol Genet. 2007;16:2021-30 pubmed
  14. Wang J, Yang L, Yang J, Kuropatwinski K, Wang W, Liu X, et al. Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells. Cancer Res. 2008;68:3152-60 pubmed publisher
    ..Stable transfection of a dominant-negative transforming growth factor beta (TGFbeta) type II receptor (DNRII) into FET cells that express autocrine TGFbeta shows loss of TGFbeta signaling and ..
  15. Wrighton K, Lin X, Yu P, Feng X. Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors. J Biol Chem. 2009;284:9755-63 pubmed publisher
    Transforming growth factor-beta (TGFbeta) superfamily ligands control a diverse set of cellular processes by activating type I and type II serine-threonine receptor kinases...
  16. Cheng P, Chang M, Chao C, Lee Y. Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation. Oncogene. 2004;23:7821-38 pubmed
    ..This functional counteraction of TGF-beta responses provides insights into possible mechanisms, whereby the HCV oncogenic proteins antagonize the host defenses during hepatocarcinogenesis. ..
  17. Di Filippo S, Zeevi A, McDade K, Bastien O, Webber S. Impact of TGFbeta1 gene polymorphisms on acute and chronic rejection in pediatric heart transplant allografts. Transplantation. 2006;81:934-9 pubmed
    ..Genetic polymorphism may reveal patients at high-risk in whom therapies and monitoring should be adjusted. ..
  18. Sturrock A, Huecksteadt T, Norman K, Sanders K, Murphy T, Chitano P, et al. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1543-55 pubmed
  19. Hatsushika K, Hirota T, Harada M, Sakashita M, Kanzaki M, Takano S, et al. Transforming growth factor-beta(2) polymorphisms are associated with childhood atopic asthma. Clin Exp Allergy. 2007;37:1165-74 pubmed
    ..The polymorphisms in TGF-beta(2) may become important information for asthma susceptibility in children. ..
  20. Szkodzinski J, Blazelonis A, Wilczek K, Hudzik B, Romanowski W, Gasior M, et al. The role of interleukin-6 and transforming growth factor-beta1 in predicting restenosis within stented infarct-related artery. Int J Immunopathol Pharmacol. 2009;22:493-500 pubmed
    ..The IL-6 plasma concentration may be a marker of in-stent restenosis in patients after PTCA, while the concentration of TGF-beta1 is not associated with the occurrence of restenosis at one year of follow-up. ..
  21. Guan X, Zhao H, Niu J, Tan D, Ajani J, Wei Q. Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. J Exp Clin Cancer Res. 2009;28:94 pubmed publisher
    ..Our study suggested that TGFB1+915CG/CC and VEGF -634CG genotypes may be associated with short-term survival in gastric cancer patients. However, larger studies are needed to verify these findings. ..
  22. Damaraju S, Murray D, Dufour J, Carandang D, Myrehaug S, Fallone G, et al. Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. Clin Cancer Res. 2006;12:2545-54 pubmed
    ..In this study, we identified SNPs in LIG4, ERCC2, and CYP2D6 genes as putative markers to predict individuals at risk for complications arising from radiation therapy in prostate cancer. ..
  23. McMahon S, Charbonneau M, Grandmont S, Richard D, Dubois C. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J Biol Chem. 2006;281:24171-81 pubmed
    ..Here, we demonstrate that TGFbeta acts on HIF-1alpha accumulation and activity by increasing HIF-1alpha protein stability...
  24. Davis B, Hilyard A, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008;454:56-61 pubmed publisher
  25. Geng Z, Zheng J, Zhang X, Tao J, Wang L. Role of transforming growth factor-beta signaling pathway in pathogenesis of benign biliary stricture. World J Gastroenterol. 2008;14:4949-54 pubmed
    ..The high expression of TGF-beta/Smad/CTGF signaling pathway plays an important role in the pathogenesis of benign biliary stricture. ..
  26. Tran D, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach E. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A. 2009;106:13445-50 pubmed publisher
    ..This latent complex can associate with latent TGFbeta-binding protein (LTBP) to produce a large latent form...
  27. Gupta S, Joshi K, Wig J, Arora S. High frequency of loss of allelic integrity at Wilms' tumor suppressor gene-1 locus in advanced breast tumors associated with aggressiveness of the tumor. Indian J Cancer. 2009;46:303-10 pubmed publisher
    ..The current study indicates that the high frequency of loss of allelic integrity at Wilms' tumor suppressor gene-1 locus in high-graded breast tumors is associated with aggressiveness of the tumor. ..
  28. Pakala S, Singh K, Reddy S, Ohshiro K, Li D, Mishra L, et al. TGF-?1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells. Oncogene. 2011;30:2230-41 pubmed publisher
  29. Hu R, Oyaizu N, Than S, Kalyanaraman V, Wang X, Pahwa S. HIV-1 gp160 induces transforming growth factor-beta production in human PBMC. Clin Immunol Immunopathol. 1996;80:283-9 pubmed
    ..Our results suggest that HIV-1 gp160 may contribute to the immune defects in HIV infection by inducing TGF-beta secretion. ..
  30. Kolundzic R, Orlic D, Trkulja V, Pavelic K, Troselj K. Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty:. J Orthop Sci. 2006;11:592-600 pubmed
    ..This preliminary study is the first to suggest that the TGF-beta1 signal sequence (29T-->C) and IL-6 promoter (-597G-->A)|(-572G-->C) transitions are predictive for the time to onset of aseptic instability after THA. ..
  31. Foreman M, DeMeo D, Hersh C, Carey V, Fan V, Reilly J, et al. Polymorphic variation in surfactant protein B is associated with COPD exacerbations. Eur Respir J. 2008;32:938-44 pubmed publisher
    ..In conclusion, genetic variation in surfactant protein B is associated with chronic obstructive pulmonary disease susceptibility and exacerbation frequency. ..
  32. Franco O, Jiang M, Strand D, Peacock J, Fernandez S, Jackson R, et al. Altered TGF-? signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis. Cancer Res. 2011;71:1272-81 pubmed publisher
    ..While the precise nature and/or origin of the particular stromal cell populations in vivo remain unknown, these findings strongly link heterogeneity in TGF-? signaling to tumor promotion by tumor stromal cells. ..
  33. Grandclement C, Pallandre J, Valmary Degano S, Viel E, Bouard A, Balland J, et al. Neuropilin-2 expression promotes TGF-?1-mediated epithelial to mesenchymal transition in colorectal cancer cells. PLoS ONE. 2011;6:e20444 pubmed publisher
    ..These results suggest that neuropilin-2 fulfills all the criteria of a therapeutic target to disrupt multiple oncogenic functions in solid tumors. ..
  34. Gagliardo R, Chanez P, Gjomarkaj M, La Grutta S, Bonanno A, Montalbano A, et al. The role of transforming growth factor-?1 in airway inflammation of childhood asthma. Int J Immunopathol Pharmacol. 2013;26:725-38 pubmed
    ..are increased in ISSs of IA and MA in comparison to C, concomitantly to the activation of intracellular signaling TGFbeta/Smads pathway in ISCs. In MA, TGF-beta1 levels correlated with the number of sputum eosinophils and neutrophils...
  35. Ito M, Hanaoka M, Droma Y, Hatayama O, Sato E, Katsuyama Y, et al. The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese. Intern Med. 2008;47:1387-94 pubmed
    ..One significant haplotype of TGFB1 is associated with the emphysema phenotype in the Japanese population. Two TGFB1 SNPs (rs1800469 and rs1982073) are associated with the severity of COPD in patients with emphysema phenotype. ..
  36. Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, et al. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. J Cell Physiol. 1999;181:153-9 pubmed
    ..The animal model on skin fibrosis by exogenous application of growth factors developed in this study may prove useful for future studies on fibrotic disorders. ..
  37. Poole K, Gibbs P, Evans P, Sadek S, Howell W. Influence of patient and donor cytokine genotypes on renal allograft rejection: evidence from a single centre study. Transpl Immunol. 2001;8:259-65 pubmed
    ..However, due to conflicting results from this and other studies, a multi-centre collaborative study may be required to determine whether cytokine genotypes are significant, independent predictors of renal allograft rejection. ..
  38. Tambur A, Ortegel J, Ben Ari Z, Shabtai E, Klein T, Michowiz R, et al. Role of cytokine gene polymorphism in hepatitis C recurrence and allograft rejection among liver transplant recipients. Transplantation. 2001;71:1475-80 pubmed
  39. Hirashima Y, Kobayashi H, Suzuki M, Tanaka Y, Kanayama N, Terao T. Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells. J Biol Chem. 2003;278:26793-802 pubmed
    ..This represents a novel pathway by which tumor cells can regulate the plasminogen activator system-dependent cellular responses in mesothelial cells that may contribute to formation of peritoneal dissemination of ovarian cancer. ..
  40. Xu Z, Shen M, Ma D, Wang L, Zha X. TGF-beta1-promoted epithelial-to-mesenchymal transformation and cell adhesion contribute to TGF-beta1-enhanced cell migration in SMMC-7721 cells. Cell Res. 2003;13:343-50 pubmed
    ..These results indicated that TGF-beta1-promoted cell adhesion and TGF-beta1-induced epithelial-to-mesenchymal transformation might be both responsible for TGF-beta1-enhanced cell migration. ..
  41. Gourley I, DeNofrio D, Rand W, Desai S, Loh E, Kamoun M. The effect of recipient cytokine gene polymorphism on cardiac transplantation outcome. Hum Immunol. 2004;65:248-54 pubmed
    ..No other significant association was found with clinical outcomes and polymorphisms in the five cytokine genes studied in this population. ..
  42. Sato F, Narita I, Goto S, Kondo D, Saito N, Ajiro J, et al. Transforming growth factor-beta1 gene polymorphism modifies the histological and clinical manifestations in Japanese patients with IgA nephropathy. Tissue Antigens. 2004;64:35-42 pubmed
    ..These results suggest that TGF-beta1 gene polymorphisms are specifically associated with heavy proteinuria and mesangial cell proliferation in Japanese patients with IgAN, although they do not confer susceptibility to this disease...
  43. Kang H, Chae M, Park J, Kim E, Park J, Kam S, et al. Polymorphisms in TGF-beta1 gene and the risk of lung cancer. Lung Cancer. 2006;52:1-7 pubmed
    ..57-0.98; P = 0.04; and adjusted OR, 0.67; 95% CI, 0.47-0.96; P = 0.02; respectively). The TGF-beta1 -509C > T and 869T > C polymorphisms and their haplotypes may contribute to genetic susceptibility to AC and SM of the lung. ..
  44. Lee K, Ho S, Lin H, Lin S, Liu C, Huang C, et al. Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway. Am J Respir Cell Mol Biol. 2006;35:407-14 pubmed
    ..These data suggest that NE upregulates TGF-beta1 gene expression and release via My88/IRAK/NF-kappaB pathway, possibly through activation of TLR4, and shed light on a potential role of neutrophils in the pathogenesis of asthma. ..
  45. Kim S, Lim J, Park S, Yang J, Kim M, Kim M, et al. Transforming growth factor-beta 1 gene polymorphisms in Korean patients with pre-eclampsia. Am J Reprod Immunol. 2010;63:291-8 pubmed publisher
    ..The TGF-beta1 c.915G>C polymorphism was not detected in our population. Our findings indicate that the TGF-beta1 c.869T>C polymorphism may be a genetic risk factor for PE and IUGR-complicated PE. ..
  46. Kamato D, Burch M, Piva T, Rezaei H, Rostam M, Xu S, et al. Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation. Cell Signal. 2013;25:2017-24 pubmed publisher
  47. Lotz M, Clark Lewis I, Ganu V. HIV-1 transactivator protein Tat induces proliferation and TGF beta expression in human articular chondrocytes. J Cell Biol. 1994;124:365-71 pubmed
    ..of the interactions between Tat and TGF beta showed that Tat increased synthesis and TGF beta activity and TGF beta 1 mRNA levels...
  48. Morrell N, Yang X, Upton P, Jourdan K, Morgan N, Sheares K, et al. Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation. 2001;104:790-5 pubmed
    ..We conclude that PASMCs from patients with PPH exhibit abnormal growth responses to TGF-beta(1) and BMPs and that altered integration of TGF-beta superfamily growth signals may contribute to the pathogenesis of PPH. ..
  49. Pulleyn L, Newton R, Adcock I, Barnes P. TGFbeta1 allele association with asthma severity. Hum Genet. 2001;109:623-7 pubmed
    ..In this study, we show that the -509T variant on haplotype 1 is the most informative marker of the TGFbeta1 contribution to asthma severity. ..
  50. Arnulf B, Villemain A, Nicot C, Mordelet E, Charneau P, Kersual J, et al. Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood. 2002;100:4129-38 pubmed
    ..Thus, we describe a new function of Tax, as a repressor of TGF-beta1 signaling through JNK/c-Jun constitutive activation, which may play a critical role in ATL leukemogenesis. ..
  51. Hubchak S, Runyan C, Kreisberg J, Schnaper H. Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulation. J Am Soc Nephrol. 2003;14:1969-80 pubmed
    ..Thus, TGF-beta1-mediated collagen I accumulation is associated with cytoskeletal rearrangement and Rho-GTPase signaling. ..
  52. Hersh C, DeMeo D, Lazarus R, Celedon J, Raby B, Benditt J, et al. Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173:977-84 pubmed
    ..02). Polymorphisms in several genes seem to be associated with COPD-related traits other than FEV(1). These associations may identify genes in pathways important for COPD pathogenesis. ..
  53. De Ruyck K, Van Eijkeren M, Claes K, Bacher K, Vral A, De Neve W, et al. TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors. Int J Radiat Oncol Biol Phys. 2006;65:1240-8 pubmed
    ..The present study shows that homozygous variant TGFbeta1 -1.552delAGG, -509TT, and 10Pro genotypes may be associated with severe clinical radiosensitivity after gynecologic RT. ..
  54. Ferrari G, Pintucci G, Seghezzi G, Hyman K, Galloway A, Mignatti P. VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis. Proc Natl Acad Sci U S A. 2006;103:17260-5 pubmed
    ..This finding illustrates an unexpected role of VEGF and indicates that VEGF can be pharmacologically converted into an apoptotic factor, a novel approach to antiangiogenesis therapy. ..
  55. Kalo E, Buganim Y, Shapira K, Besserglick H, Goldfinger N, Weisz L, et al. Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II. Mol Cell Biol. 2007;27:8228-42 pubmed
    ..These data provide important insights into the molecular mechanisms that underlie mutant p53 "gain of function" pertaining to the TGF-beta signaling pathway. ..
  56. Bantis C, Heering P, Aker S, Kuhr N, Grabensee B, Ivens K. Influence of cytokine gene polymorphisms on IgA nephropathy. Ren Fail. 2008;30:135-40 pubmed publisher
    ..Conclusion. Our results suggest that TGF-beta1 gene Arg(25)-->Pro, TNFalpha gene G-308A, and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in Caucasian patients with IgA nephropathy...
  57. Do T, Kubba L, Du H, Sturgis C, Woodruff T. Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition. Mol Cancer Res. 2008;6:695-705 pubmed publisher
    ..0057). Collectively, these results implicate an important role for the TGF-beta/Smad3 pathway in mediating ovarian oncogenesis by enhancing metastatic potential. ..
  58. Wu G, Hasenberg T, Magdeburg R, Bönninghoff R, Sturm J, Keese M. Association between EGF, TGF-beta1, VEGF gene polymorphism and colorectal cancer. World J Surg. 2009;33:124-9 pubmed publisher
    ..The EGF 61 G/G genotype and the G allele are significantly related to colorectal cancer. The TGF-beta1 -509 T/C and VEGF 936 T/C gene polymorphisms are not related to colorectal cancer. ..
  59. Soliman G, Mohammed K, Taha A, Barrak A. The role of plasma transforming growth factor beta-1 in the development of fibrosis in patient with HCV related steatohepatitis. J Egypt Soc Parasitol. 2010;40:759-72 pubmed
    ..Plasma transforming growth factor Beta-1 (TGFB-1) is a member of large family of peptides, which has a major regulatory role in hepatic fibrosis and cirrhosis...
  60. Murphy Ullrich J, Schultz Cherry S, Hook M. Transforming growth factor-beta complexes with thrombospondin. Mol Biol Cell. 1992;3:181-8 pubmed
    ..Hence, TGF-beta can bind to TSP, and the complex forms under physiological conditions. Furthermore, TSP-associated TGF-beta is biologically active, and the binding of TGF-beta to TSP may protect TGF-beta from extracellular inactivators. ..
  61. Saharinen J, Taipale J, Keski Oja J. Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. EMBO J. 1996;15:245-53 pubmed
    ..factor-betas (TGF-betas) are produced by most cells in large latent complexes of TGF-beta and its propeptide (LAP) associated with a binding protein...
  62. Chen W, Lenschow W, Tiede K, Fischer J, Kalthoff H, Ungefroren H. Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. J Biol Chem. 2002;277:36118-28 pubmed
  63. Xiong B, Yuan H, Hu M, Zhang F, Wei Z, Gong L, et al. Transforming growth factor-beta1 in invasion and metastasis in colorectal cancer. World J Gastroenterol. 2002;8:674-8 pubmed
    ..It increased the invasive and metastatic potential of tumor by altering a tumor microenvironment. TGFbeta1 may be used as a possible biomarker. ..
  64. Watanabe Y, Kinoshita A, Yamada T, Ohta T, Kishino T, Matsumoto N, et al. A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway. J Hum Genet. 2002;47:478-83 pubmed
    ..We also estimated allele frequencies of these DNA polymorphisms among 48 Japanese individuals. Our data will provide a useful resource for the study of disease susceptibility. ..
  65. Chaturvedi N, Schalkwijk C, Abrahamian H, Fuller J, Stehouwer C. Circulating and urinary transforming growth factor beta1, Amadori albumin, and complications of type 1 diabetes: the EURODIAB prospective complications study. Diabetes Care. 2002;25:2320-7 pubmed
    ..In contrast, only circulating TGF-beta1 was related to proliferative retinopathy, and HbA(1c) largely accounted for this. These findings may indicate novel pathways for understanding mechanisms and therapeutic interventions. ..
  66. Gressner A, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med. 2006;10:76-99 pubmed
  67. Piao M, Tokunaga O. Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study. J Atheroscler Thromb. 2006;13:82-9 pubmed
    To date, the glycoprotein endoglin and its receptor complex, formed between TGFbeta and TGFbeta R-2, have been studied in tumor angiogenesis...
  68. Bosse Y, Rola Pleszczynski M. Controversy surrounding the increased expression of TGF beta 1 in asthma. Respir Res. 2007;8:66 pubmed
  69. Yan X, Liu Z, Chen Y. Regulation of TGF-beta signaling by Smad7. Acta Biochim Biophys Sin (Shanghai). 2009;41:263-72 pubmed
    ..Overexpression of Smad7 has been shown to antagonize TGF-beta-mediated fibrosis, carcinogenesis, and inflammation, suggesting a therapeutic potential of Smad7 to treat these diseases. ..
  70. Bierie B, Chung C, Parker J, Stover D, Cheng N, Chytil A, et al. Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer. J Clin Invest. 2009;119:1571-82 pubmed publisher
    ..Together, the results suggest that assessment of TGF-beta signaling pathway status may further stratify the prognosis of ER-positive patients and provide novel therapeutic approaches in the management of breast cancer. ..
  71. Teixeira A, Ribeiro R, Morais A, Lobo F, Fraga A, Pina F, et al. Combined analysis of EGF+61G>A and TGFB1+869T>C functional polymorphisms in the time to androgen independence and prostate cancer susceptibility. Pharmacogenomics J. 2009;9:341-6 pubmed publisher
    ..Combined blockage of key molecules in proliferation signaling pathways could be one of the most promising strategies for androgen-independent prostate cancer. ..
  72. Xie Y, Zeng K, Wang Y, Xu H. TGF-beta1-800G>A polymorphism and cerebral infarction in Chinese Han population. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:1166-70 pubmed
    ..05). Logistic regression analysis suggested that no genotypes could increase or reduce the risk of CI onset (P>0.05). TGF-beta1-800G>A polymorphism is not associated with CI in Han population in Hunan Province. ..
  73. Korten S, Kaifi J, Büttner D, Hoerauf A. Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia. Microbes Infect. 2010;12:555-64 pubmed publisher
    ..TGF-beta(+) cells were reduced in HIV co-infection. This finding of local and sustained TGF-beta induction by vital and dead filariae, untreated and after treatment, adds new aspects to immunomodulation by helminths. ..
  74. Liu J, Liao S, Diop Frimpong B, Chen W, Goel S, Naxerova K, et al. TGF-? blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2012;109:16618-23 pubmed publisher