TFIIB

Summary

Gene Symbol: TFIIB
Description: general transcription factor IIB
Alias: TF2B, TFIIB, transcription initiation factor IIB, RNA polymerase II transcription factor IIB, S300-II, general transcription factor TFIIB
Species: human
Products:     TFIIB

Top Publications

  1. Nikolov D, Chen H, Halay E, Usheva A, Hisatake K, Lee D, et al. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature. 1995;377:119-28 pubmed
    The crystal structure of the transcription factor IIB (TFIIB)/TATA box-binding protein (TBP)/TATA-element ternary complex is described at 2.7 A resolution...
  2. Agostini I, Navarro J, Rey F, Bouhamdan M, Spire B, Vigne R, et al. The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB. J Mol Biol. 1996;261:599-606 pubmed
    ..machinery, in vitro protein-protein binding assays were performed using either translated, radiolabeled Vpr or TFIIB proteins and glutathione S-transferase Vpr or TFIIB chimeric proteins...
  3. Choi C, Hiromura M, Usheva A. Transcription factor IIB acetylates itself to regulate transcription. Nature. 2003;424:965-9 pubmed
    ..Here we show that the general transcription factor TFIIB, which is required for the initiation of eukaryotic polymerase II transcription, is acetylated...
  4. Glossop J, Dafforn T, Roberts S. A conformational change in TFIIB is required for activator-mediated assembly of the preinitiation complex. Nucleic Acids Res. 2004;32:1829-35 pubmed
    b>TFIIB plays a pivotal role during assembly of the RNA polymerase II transcription preinitiation complex. TFIIB is composed of two domains that engage in an intramolecular interaction that can be disrupted by the VP16 activation domain...
  5. Chen H, Lin R, Schiltz R, Chakravarti D, Nash A, Nagy L, et al. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell. 1997;90:569-80 pubmed
  6. Kino T, Gragerov A, Kopp J, Stauber R, Pavlakis G, Chrousos G. The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor. J Exp Med. 1999;189:51-62 pubmed
    ..The glucocorticoid coactivator activity of Vpr may contribute to increased tissue glucocorticoid sensitivity in the absence of hypercortisolism and to the pathogenesis of AIDS. ..
  7. Bushnell D, Westover K, Davis R, Kornberg R. Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms. Science. 2004;303:983-8 pubmed
    The structure of the general transcription factor IIB (TFIIB) in a complex with RNA polymerase II reveals three features crucial for transcription initiation: an N-terminal zinc ribbon domain of TFIIB that contacts the "dock" ..
  8. Pal M, Ponticelli A, Luse D. The role of the transcription bubble and TFIIB in promoter clearance by RNA polymerase II. Mol Cell. 2005;19:101-10 pubmed
    ..evidence that bubble collapse suppresses pausing at +7 to +9 caused by the presence of the B finger segment of TFIIB within the complex...
  9. Elsby L, O Donnell A, Green L, Sharrocks A, Roberts S. Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II. EMBO Rep. 2006;7:898-903 pubmed
    The general transcription factor TFIIB has a central role in the assembly of the preinitiation complex at the promoter, providing a platform for the entry of RNA polymerase II/TFIIF...

More Information

Publications167 found, 100 shown here

  1. Wang Y, Fairley J, Roberts S. Phosphorylation of TFIIB links transcription initiation and termination. Curr Biol. 2010;20:548-53 pubmed publisher
    The general transcription factor TFIIB plays a central role in preinitiation complex (PIC) assembly and the recruitment of RNA polymerase II (RNA pol II) to the promoter...
  2. Li L, Zhang A, Cao X, Chen J, Xia Y, Zhao H, et al. General transcription factor IIb overexpression and a potential link to proliferation in human hepatocellular carcinoma. Pathol Oncol Res. 2013;19:195-203 pubmed publisher
    The general transcription factor IIB (TFIIB) plays a central role in preinitiation complex (PIC) assembly, providing a bridge between promoter-bound TFIID and RNA Polymerase II (RNA POLII)...
  3. Lagrange T, Kapanidis A, Tang H, Reinberg D, Ebright R. New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. Genes Dev. 1998;12:34-44 pubmed
  4. Shiraishi S, Tamamura N, Jogo M, Tanaka Y, Tamura T. Rapid proteasomal degradation of transcription factor IIB in accordance with F9 cell differentiation. Gene. 2009;436:115-20 pubmed publisher
    ..Different from other GTFs, decrease of TFIIB during the differentiation was suppressed by addition of a proteasome inhibitor, MG132...
  5. Casey L, Wen X, de Noronha C. The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase. Cytokine. 2010;51:1-9 pubmed publisher
    ..Here, we discuss the multiple functions that have been linked to Vpr expression and summarize the current knowledge on the role of the ubiquitin ligase complex in carrying out a subset of these activities. ..
  6. Liu S, Balasov M, Wang H, Wu L, Chesnokov I, Liu Y. Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. Proc Natl Acad Sci U S A. 2011;108:7373-8 pubmed publisher
    ..This domain has an overall fold similar to the corresponding helical domain of transcription factor TFIIB. Based on these findings, a model of Orc6 binding to DNA is produced...
  7. Yamamoto S, Hagihara T, Horiuchi Y, Okui A, Wani S, Yoshida T, et al. Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-?B and C/EBP? on stimulation of Toll-like receptor 9. Genes Cells. 2017;22:265-276 pubmed publisher
    ..MED1, inflammation-related transcriptional activator NF-?B and C/EBP?, and general transcription factors TFIIE and TFIIB colocalized at the promoter regions of these genes under this condition...
  8. Khoo S, Wu C, Lin Y, Chen H. The TFIIE-related Rpc82 subunit of RNA polymerase III interacts with the TFIIB-related transcription factor Brf1 and the polymerase cleft for transcription initiation. Nucleic Acids Res. 2017;: pubmed publisher
    ..Site-specific photo-crosslinking analysis indicated that the WH3 insertion interacts with the TFIIB-related transcription factor Brf1 within the pre-initiation complex (PIC)...
  9. PANDEY R, Datta D, Mukerjee R, Srinivasan A, Mahalingam S, Sawaya B. HIV-1 Vpr: a closer look at the multifunctional protein from the structural perspective. Curr HIV Res. 2009;7:114-28 pubmed
    ..The inter-relationship between different functions of Vpr is discussed in the context of structure. Based on bioinformatics analysis, we propose new targets for modulating Vpr functions, which need to be validated experimentally. ..
  10. Zhong Q, Xi S, Liang J, Shi G, Huang Y, Zhang Y, et al. The significance of Brf1 overexpression in human hepatocellular carcinoma. Oncotarget. 2016;7:6243-54 pubmed publisher
    Brf1 (TFIIB-related factor 1) plays a crucial role in cell transformation and tumorigenesis. However, the significance of Brf1 expression in human HCC (hepatocellular carcinoma) cases remains to be addressed...
  11. Jishage M, Yu X, Shi Y, Ganesan S, Chen W, Sali A, et al. Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. Nat Struct Mol Biol. 2018;25:859-867 pubmed publisher
    ..domains were localized and shown to occlude transcription factor IIF (TFIIF) and transcription factor IIB (TFIIB) binding by perfect positioning on their Pol II interaction sites...
  12. Desai Yajnik V, Hadzic E, Modlinger P, Malhotra S, Gechlik G, Samuels H. Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator. J Virol. 1995;69:5103-12 pubmed
    ..that the 50-amino-acid N-terminal A/B region of T3R alpha, known to interact with the basal transcription factor TFIIB, is critical for activation of both Tat-dependent and Tat-independent responsive sequences of the LTR...
  13. Ha I, Roberts S, Maldonado E, Sun X, Kim L, Green M, et al. Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II. Genes Dev. 1993;7:1021-32 pubmed
    Transcription factor IIB (TFIIB) plays a pivotal role in the formation of transcription-competent initiation complexes. TFIIB was found to interact with the TATA-binding protein, the small subunit of TFIIF, and RNA polymerase II...
  14. Varadé J, Comabella M, Ortiz M, Arroyo R, Fernandez O, Pinto Medel M, et al. Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes. Mult Scler. 2012;18:959-65 pubmed publisher
    ..001; OR(M-H) (95% CI)= 0.84 (0.75-0.93)], IL12B [rs6887695: p(M-H)=0.03; OR(M-H) (95% CI)= 1.09 (1.01-1.17)] and CBLB [rs9657904: p(M-H)=0.01; OR(M-H) (95% CI)= 0.89 (0.81-0.97)]. ..
  15. Akhmetova K, Balasov M, Huijbregts R, Chesnokov I. Functional insight into the role of Orc6 in septin complex filament formation in Drosophila. Mol Biol Cell. 2015;26:15-28 pubmed publisher
    ..Orc6 forms dimers through the interactions of its N-terminal, TFIIB-like domains...
  16. Friedman M, Shah A, Fang Z, Ward E, Warren S, Li S, et al. Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nat Neurosci. 2007;10:1519-28 pubmed
    ..tracts reduced TBP dimerization but enhanced the interaction of TBP with the general transcription factor IIB (TFIIB)...
  17. Jin H, Kaplan C. Relationships of RNA polymerase II genetic interactors to transcription start site usage defects and growth in Saccharomyces cerevisiae. G3 (Bethesda). 2014;5:21-33 pubmed publisher
    ..Transcription Factor (GTF) alleles, with reduced-activity Pol II mutants especially sensitive to defects in TFIIB. However, Pol II mutant growth defects could be uncoupled from TSS selection defects in some Pol II allele-GTF ..
  18. Tourigny J, Saleh M, Schumacher K, Devys D, Zentner G. Mediator Is Essential for Small Nuclear and Nucleolar RNA Transcription in Yeast. Mol Cell Biol. 2018;38: pubmed publisher
    ..regulatory regions and that rapid depletion of the essential structural subunit Med14 strongly reduces RNAPII and TFIIB occupancy as well as nascent transcription of sn/snoRNA genes...
  19. Zhao P, Kavarthapu R, Anbazhagan R, Liao M, Dufau M. Interaction of positive coactivator 4 with histone 3.3 protein is essential for transcriptional activation of the luteinizing hormone receptor gene. Biochim Biophys Acta Gene Regul Mech. 2018;1861:971-981 pubmed publisher
    ..Depletion of H3.3 A/B in MCF7 cells impair chromatin accessibility and enrichment of Pol II and TFIIB at the LHR promoter and its activation, resulting in marked reduction of LHR gene expression...
  20. Reinberg D, Roeder R. Factors involved in specific transcription by mammalian RNA polymerase II. Purification and functional analysis of initiation factors IIB and IIE. J Biol Chem. 1987;262:3310-21 pubmed
    ..b>TFIIB and TFIIE were also required, in addition to TFIIA, TFIID, RNA polymerase II, and the adenovirus 2 major late ..
  21. Umehara T, Kida S, Yamamoto T, Horikoshi M. Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II. Gene. 1995;167:297-302 pubmed
    ..The significance of tissue-specific S-II molecules for the regulation of transcription elongation is discussed. ..
  22. Scully R, Anderson S, Chao D, Wei W, Ye L, Young R, et al. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A. 1997;94:5605-10 pubmed
    ..These data are consistent with recent data identifying transcription activation domains in the BRCA1 protein and link the BRCA1 tumor suppressor protein with the transcription process as a holoenzyme-bound protein. ..
  23. Benson J, Lawande R, Howley P. Conserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins. J Virol. 1997;71:8041-7 pubmed
    ..encoded by bovine papillomavirus type 1 (BPV-1), has been shown to interact with basal transcription factor IIB (TFIIB) and the TATA binding protein basal transcription factor (N. M. Rank and P. F. Lambert, J. Virol...
  24. Na S, Choi H, Kim J, Na D, Lee J. Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor. J Biol Chem. 1998;273:30933-8 pubmed
    ..Bcl3 specifically interacted with the general transcription factors TFIIB, TBP, and TFIIA but not with TFIIEalpha in the GST pull-down assays...
  25. Zhao X, Schramm L, Hernandez N, Herr W. A shared surface of TBP directs RNA polymerase II and III transcription via association with different TFIIB family members. Mol Cell. 2003;11:151-61 pubmed
    ..Second, unlike yeast TBP, human TBP can use a shared surface to interact with two different TFIIB family members--TFIIB and Brf2--to initiate transcription by different RNA polymerases.
  26. Blattner C, Jennebach S, Herzog F, Mayer A, Cheung A, Witte G, et al. Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth. Genes Dev. 2011;25:2093-105 pubmed publisher
    ..Consistent with this, the Rrn3-binding factor Rrn7 is predicted to be a TFIIB homolog...
  27. Srivastava A, Badjatia N, Lee J, Hao B, GUNZL A. An RNA polymerase II-associated TFIIF-like complex is indispensable for SL RNA gene transcription in Trypanosoma brucei. Nucleic Acids Res. 2017;: pubmed publisher
    ..that form the PIC are extremely divergent orthologues of the small nuclear RNA-activating complex, TBP, TFIIA, TFIIB, TFIIH, TFIIE and Mediator...
  28. Cavailles V, Dauvois S, L Horset F, Lopez G, Hoare S, Kushner P, et al. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J. 1995;14:3741-51 pubmed
    ..In view of its widespread expression in mammalian cells, RIP140 may interact with other members of the superfamily of nuclear receptors and thereby act as a potential co-activator of hormone-regulated gene transcription. ..
  29. Johnston S, Liu X, Zuo F, Eisenbraun T, Wiley S, Kraus R, et al. Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol Endocrinol. 1997;11:342-52 pubmed
    ..It was also shown to interact with both ER alpha and the transcription factor TFIIB by direct protein-protein contacts...
  30. Yanagi S, Shimbara N, Tamura T. Tissue and cell distribution of a mammalian proteasomal ATPase, MSS1, and its complex formation with the basal transcription factors. Biochem Biophys Res Commun. 2000;279:568-73 pubmed
    ..Interestingly, multiple basal transcription factors for RNA polymerase II, including TBP, TFIIB, TFIIH, and TFIIF, were found to be associated with MSS1...
  31. Hu H, Wu C, Lee J, Chen H. A Region of Bdp1 Necessary for Transcription Initiation That Is Located within the RNA Polymerase III Active Site Cleft. Mol Cell Biol. 2015;35:2831-40 pubmed publisher
    ..Mutations within the highly conserved SANT domain cross-linked to the transcription factor IIB (TFIIB)-related transcription factor Brf1, consistent with the findings of previous studies...
  32. Gouge J, Satia K, Guthertz N, Widya M, Thompson A, Cousin P, et al. Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell. 2015;163:1375-87 pubmed publisher
    b>TFIIB-related factor 2 (Brf2) is a member of the family of TFIIB-like core transcription factors. Brf2 recruits RNA polymerase (Pol) III to type III gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes...
  33. Kylie K, Romero J, Lindamulage I, Knockleby J, Lee H. Dynamic regulation of histone H3K9 is linked to the switch between replication and transcription at the Dbf4 origin-promoter locus. Cell Cycle. 2016;15:2321-35 pubmed publisher
    ..We also found that proteins critical for the regulation of replication (ORC, MCM), transcription (SP1, TFIIB), and cohesin (Smc1, Smc3) and Mediator functions (Med1, Med12) interact with specific sites within and the ..
  34. Chen H, Legault P, Glushka J, Omichinski J, Scott R. Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription. Protein Sci. 2000;9:1743-52 pubmed
    Transcription factor IIB (TFIIB) is an essential component in the formation of the transcription initiation complex in eucaryal and archaeal transcription...
  35. de Oliveira A, Prince D, Lo C, Lee L, Chu T. Antiviral activity of theaflavin digallate against herpes simplex virus type 1. Antiviral Res. 2015;118:56-67 pubmed publisher
    ..theaflavin polyphenols, in particular theaflavin (TF1), theaflavin-3-monogallate (TF2A), theaflavin-3'-monogallate (TF2B), and theaflavin-3,3'-digallate (TF3)...
  36. Vosnakis N, Koch M, Scheer E, Kessler P, Mely Y, Didier P, et al. Coactivators and general transcription factors have two distinct dynamic populations dependent on transcription. EMBO J. 2017;36:2710-2725 pubmed publisher
    ..SAGA and ATAC, but also two general transcription factors (TFIID and TFIIB), were highly dynamic, exhibiting mainly transient associations with chromatin, contrary to Pol II, which formed ..
  37. Roeder R. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci. 1996;21:327-35 pubmed
  38. Alen P, Claessens F, Schoenmakers E, Swinnen J, Verhoeven G, Rombauts W, et al. Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. Mol Endocrinol. 1999;13:117-28 pubmed
    ..activity, but it does interact with another histone acetyltransferase, p/CAF, and the basal transcription factor TFIIB. The interaction with the AR occurs through the ligand-binding domain and involves the region corresponding to the ..
  39. Zhang Y, Dufau M. Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB. Mol Cell Biol. 2003;23:6958-72 pubmed
    ..Furthermore, we demonstrate interaction of TFIIB with Sp1/Sp3 at the Sp1(I) site besides its association with EAR3 and the TATA-less core promoter region...
  40. Masters K, Parkhurst K, Daugherty M, Parkhurst L. Native human TATA-binding protein simultaneously binds and bends promoter DNA without a slow isomerization step or TFIIB requirement. J Biol Chem. 2003;278:31685-90 pubmed
    ..hTBPwt-DNAAdMLP model characterized by low affinity (microM) binding and an unstable complex requiring either a 30-min isomerization or TFIIB to achieve DNA bending. Possible sources of these significant differences are discussed.
  41. Murai K, Naruse Y, Shaul Y, Agata Y, Mori N. Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription. Nucleic Acids Res. 2004;32:3180-9 pubmed
    ..Thus, the RD-1 and RD-2 repression domains of NRSF utilize both chromatin-dependent and chromatin-independent mechanisms, which may be segregated at various stages of neural development and modulation. ..
  42. Ing N, Beekman J, Tsai S, Tsai M, O Malley B. Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J Biol Chem. 1992;267:17617-23 pubmed
    ..Cloning and sequencing of S300-II showed that it is the general transcription factor TFIIB. Specific protein-protein interactions between recombinant S300-II/TFIIB and three members of the ..
  43. Kim S, Jang H, Albrecht R, Derbigny W, Zhang Y, O Callaghan D. Interaction of the equine herpesvirus 1 EICP0 protein with the immediate-early (IE) protein, TFIIB, and TBP may mediate the antagonism between the IE and EICP0 proteins. J Virol. 2003;77:2675-85 pubmed
    ..Assays with IE mutant proteins revealed that its DNA-binding domain, TFIIB-binding domain, and nuclear localization signal may be important for the antagonism between the IE and EICP0 ..
  44. Liu Y, Dong W, Chen L, Zhang P, Qi Y. Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB. Biochem Biophys Res Commun. 2004;320:1-6 pubmed
    ..This was done in the context of its interaction with TFIIB, as well as its ability to activate transcription as a fusion protein linked to the DNA-binding domain of Gal4 in ..
  45. ÄŒabart P, Jin H, Li L, Kaplan C. Activation and reactivation of the RNA polymerase II trigger loop for intrinsic RNA cleavage and catalysis. Transcription. 2014;5:e28869 pubmed publisher
    ..type TL function and that H1085Y substitution within the TL compromises or alters RNAP II responsiveness to both TFIIB and TFIIF...
  46. To K, Tong W, Fu L. Reversal of platinum drug resistance by the histone deacetylase inhibitor belinostat. Lung Cancer. 2017;103:58-65 pubmed publisher
    ..of a transcriptional repressor (negative cofactor 2) but reduced association of a transcriptional activator (TFIIB) to the ABCC2 promoter...
  47. Johnston S, Yu X, Mertz J. The major transcriptional transactivation domain of simian virus 40 large T antigen associates nonconcurrently with multiple components of the transcriptional preinitiation complex. J Virol. 1996;70:1191-202 pubmed
    ..We show here that (i) the Tag domain containing amino acids 133 to 249 directly interacts with the general transcription factor TFIIB, the activator protein Sp1, and the 140-kDa subunit of RNA polymerase II, as well as with TBP and ..
  48. Liang G, Hai T. Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein. J Biol Chem. 1997;272:24088-95 pubmed
    ..Our results indicate that hATF4 interacts with several general transcription factors: TATA-binding protein, TFIIB, and the RAP30 subunit of TFIIF...
  49. Kimura H, Tao Y, Roeder R, Cook P. Quantitation of RNA polymerase II and its transcription factors in an HeLa cell: little soluble holoenzyme but significant amounts of polymerases attached to the nuclear substructure. Mol Cell Biol. 1999;19:5383-92 pubmed
    ..molecules of polymerases (approximately 110,000 molecules of form IIO) and 10,000 to 30,000 molecules of each of TFIIB, TFIIEalpha, TFIIEbeta, TFIIF-RAP74, TFIIF-RAP30, and TFIIH-MAT1 remained tightly associated with the nuclear ..
  50. López Muñoz G, Estevez M, Peláez Gutierrez E, Homs Corbera A, García Hernandez M, Imbaud J, et al. A label-free nanostructured plasmonic biosensor based on Blu-ray discs with integrated microfluidics for sensitive biodetection. Biosens Bioelectron. 2017;96:260-267 pubmed publisher
    ..We have achieved a LOD in the pM order and have assessed the feasibility of directly measuring biological samples such as human serum. ..
  51. Chiu C, Tsay Y, Chang C, Lee S. Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene. J Biol Chem. 2002;277:39102-11 pubmed
    ..In summary, we demonstrate the existence of a novel Nopp140-mediated PKA signaling pathway that leads to the activation of agp, one of the major acute phase response genes. ..
  52. Hsu L, Liu S, Abedinpour F, Beech R, Lahti J, Kidd V, et al. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Mol Cell Biol. 2003;23:8773-85 pubmed
    ..blot analyses demonstrated that mGPBP is a nuclear factor that can form complexes with TATA-binding protein, TFIIB, TFIIF, RNA polymerase II, and P300/CBP both in vitro and in intact cells...
  53. Sebastian W, Sukumaran S, Zacharia P, Gopalakrishnan A. Isolation and characterization of Aquaporin 1 (AQP1), sodium/potassium-transporting ATPase subunit alpha-1 (Na/K-ATPase α1), Heat Shock Protein 90 (HSP90), Heat Shock Cognate 71 (HSC71), Osmotic Stress Transcription Factor 1 (OSTF1) and Transcription. Mol Biol Rep. 2018;45:2783-2789 pubmed publisher
    ..alpha-1 (Na/K-ATPase α1 subunit), Osmotic Stress Transcription Factor 1 (OSTF1), Transcription Factor II B (TFIIB), Heat Shock Cognate 71 (HSC71) and Heat Shock Protein 90 (HSP90) obtained from mRNA and genomic DNA of Etroplus ..
  54. Kim S, Shakya A, O Callaghan D. Full trans-activation mediated by the immediate-early protein of equine herpesvirus 1 requires a consensus TATA box, but not its cognate binding sequence. Virus Res. 2016;211:222-32 pubmed publisher
    ..essential for trans-activation, including an acidic trans-activation domain (TAD) and binding domains for DNA, TFIIB, and TBP...
  55. Gelev V, Zabolotny J, Lange M, Hiromura M, Yoo S, Orlando J, et al. A new paradigm for transcription factor TFIIB functionality. Sci Rep. 2014;4:3664 pubmed publisher
    ..However, the general transcription factor TFIIB is presumed to be universally required for RNAP2 transcription initiation...
  56. Gao Y, Rankin G, Tu Y, Chen Y. Inhibitory Effects of the Four Main Theaflavin Derivatives Found in Black Tea on Ovarian Cancer Cells. Anticancer Res. 2016;36:643-51 pubmed
    ..Theaflavin (TF1), theaflavin-3-gallate (TF2a), theaflavin-3'-gallate (TF2b) and theaflavin-3, 3'-digallate (TF3) are four main theaflavin derivatives found in black tea...
  57. Chowdhary S, Kainth A, Gross D. Heat Shock Protein Genes Undergo Dynamic Alteration in Their Three-Dimensional Structure and Genome Organization in Response to Thermal Stress. Mol Cell Biol. 2017;37: pubmed publisher
    ..Notably, a missense mutation in transcription factor TFIIB suppresses gene looping, yet neither crumpling nor HSP gene coalescence is affected...
  58. Schmitz M, Stelzer G, Altmann H, Meisterernst M, Baeuerle P. Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators. J Biol Chem. 1995;270:7219-26 pubmed
    ..of the p65 subunit of human transcription factor NF-kappa B directly binds the general transcription factors TFIIB and TATA-binding protein (TBP) in vitro...
  59. Yu L, Loewenstein P, Zhang Z, Green M. In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP. J Virol. 1995;69:3017-23 pubmed
    ..Mao, J.S. Symington, and M. Green, J. Virol. 69:3007-3016, 1995). Here we show that TAP binds the general transcription factor TFIIB. Furthermore, we delineate the binding domains of TAP, Tat, and TFIIB, as well as measure the ..
  60. Veschambre P, Roisin A, Jalinot P. Biochemical and functional interaction of the human immunodeficiency virus type 1 Tat transactivator with the general transcription factor TFIIB. J Gen Virol. 1997;78 ( Pt 9):2235-45 pubmed
    ..The results presented in this report indicate that the effect exerted by Tat also involves an interaction with TFIIB. A direct protein-protein interaction between Tat and TFIIB was observed in vitro...
  61. Kino T, Chrousos G. Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?. Ann N Y Acad Sci. 2004;1024:153-67 pubmed
  62. Reddi A, Pawlowska M, Gibney B. Evaluation of the Intrinsic Zn(II) Affinity of a Cys3His1 Site in the Absence of Protein Folding Effects. Inorg Chem. 2015;54:5942-8 pubmed publisher
    ..with and without Zn(II) bound, the 59 amino acid zinc binding domain of human transcription factor IIB (ZBD-TFIIB). The formation constant of Zn(II)-ZBD-TFIIB, which contains a single Cys3His1 site, was determined to be 1...
  63. Lloret Llinares M, Mapendano C, Martlev L, Lykke Andersen S, Jensen T. Relationships between PROMPT and gene expression. RNA Biol. 2016;13:6-14 pubmed publisher
    ..For the CTSZ and DAP genes we find that TFIIB and TBP promoter binding decrease when PROMPTs accumulate...
  64. Yu L, Zhang Z, Loewenstein P, Desai K, Tang Q, Mao D, et al. Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain. J Virol. 1995;69:3007-16 pubmed
    ..shown in an accompanying report, the TAP activation region binds the Tat core activation region and general transcription factor TFIIB (L. Yu, P.M. Loewenstein, Z. Zhang, and M. Green, J. Virol. 69:3017-3023, 1995)...
  65. Heng H, Xiao H, Shi X, Greenblatt J, Tsui L. Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. Hum Mol Genet. 1994;3:61-4 pubmed
    ..in situ hybridization (FISH), we show here that the genes encoding the TATA-box binding protein (TBP), TFIIB, TFIIE alpha, TFIIE beta, RAP30, RAP74 and the 62 kDa subunit, of TFIIH are located at the human chromosomal bands ..
  66. Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii Kuriyama Y, Sogawa K. Transcriptional activation domain of human BTEB2, a GC box-binding factor. J Biochem. 1997;121:389-96 pubmed
    ..Basic transcription factors which possibly interact with BTEB2 were examined. Initiation factors, TFIIB, TFIIE beta, and TFIIF beta as well as the TATA box-binding protein (TBP) were found to interact with BTEB2 when ..
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