TFEB

Summary

Gene Symbol: TFEB
Description: transcription factor EB
Alias: ALPHATFEB, BHLHE35, TCFEB, transcription factor EB, T-cell transcription factor EB, class E basic helix-loop-helix protein 35
Species: human
Products:     TFEB

Top Publications

  1. Settembre C, Di Malta C, Polito V, Garcia Arencibia M, Vetrini F, Erdin S, et al. TFEB links autophagy to lysosomal biogenesis. Science. 2011;332:1429-33 pubmed publisher
    ..The transcription factor EB (TFEB), a master gene for lysosomal biogenesis, coordinated this program by driving expression of ..
  2. Medina D, Fraldi A, Bouchè V, Annunziata F, Mansueto G, Spampanato C, et al. Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell. 2011;21:421-30 pubmed publisher
    ..This process has an important role in secretion and PM repair. Here we show that the transcription factor EB (TFEB) regulates lysosomal exocytosis...
  3. Settembre C, Zoncu R, Medina D, Vetrini F, Erdin S, Erdin S, et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 2012;31:1095-108 pubmed publisher
    ..However, the mechanisms mediating lysosomal adaptation are largely unknown. Here, we show that the Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis, colocalizes with master growth regulator mTOR complex ..
  4. Martina J, Chen Y, Gucek M, Puertollano R. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy. 2012;8:903-14 pubmed publisher
    ..Here we show that MTORC1 regulates nuclear localization and activity of the transcription factor EB (TFEB), a member of the bHLH leucine-zipper family of transcription factors that drives expression of ..
  5. Song W, Wang F, Lotfi P, Sardiello M, Segatori L. 2-Hydroxypropyl-?-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014;289:10211-22 pubmed publisher
    ..Here, we show that cell treatment with HP?CD results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in enhancement of the cellular autophagic ..
  6. Sardiello M, Palmieri M, di Ronza A, Medina D, Valenza M, Gennarino V, et al. A gene network regulating lysosomal biogenesis and function. Science. 2009;325:473-7 pubmed publisher
    ..We found that most lysosomal genes exhibit coordinated transcriptional behavior and are regulated by the transcription factor EB (TFEB)...
  7. Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, et al. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum Mol Genet. 2011;20:3852-66 pubmed publisher
    ..discovered the CLEAR (Coordinated Lysosomal Expression and Regulation) gene network and its master gene transcription factor EB (TFEB), which regulates lysosomal biogenesis and function...
  8. Roczniak Ferguson A, Petit C, Froehlich F, Qian S, Ky J, Angarola B, et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal. 2012;5:ra42 pubmed publisher
    ..lysosome-localized mechanistic target of rapamycin complex 1 (mTORC1) and the transcription factor TFEB (transcription factor EB), which promotes lysosome biogenesis...
  9. Song W, Wang F, Savini M, Ake A, di Ronza A, Sardiello M, et al. TFEB regulates lysosomal proteostasis. Hum Mol Genet. 2013;22:1994-2009 pubmed publisher
    ..Here, we investigate the role of the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and function, in modulating lysosomal proteostasis in ..

More Information

Publications124 found, 100 shown here

  1. Polishchuk E, Merolla A, Lichtmannegger J, Romano A, Indrieri A, Ilyechova E, et al. Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis. Gastroenterology. 2019;156:1173-1189.e5 pubmed publisher
    ..activity and was dissociated from lysosomes; this resulted in translocation of the mTOR substrate transcription factor EB to the nucleus and activation of autophagy-related genes...
  2. Lotfi P, Tse D, di Ronza A, Seymour M, Martano G, Cooper J, et al. Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Autophagy. 2018;14:1419-1434 pubmed publisher
    ..saline; PRKCA/PKCα: protein kinase C, alpha; S1BF: somatosensory cortex; SQSTM1: sequestosome 1; TEM: transmission electron microscopy; TFEB: transcription factor EB; VMP/VPL: ventral posterior nuclei of the thalamus.
  3. Das R, Melo J, Thondamal M, Morton E, Cornwell A, Crick B, et al. The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans. PLoS Genet. 2017;13:e1007038 pubmed publisher
    ..The autophagy-stimulating transcription factors pha-4/FoxA and mxl-2/Mlx, but not hlh-30/TFEB or the nuclear hormone receptor nhr-62, are necessary for extended longevity resulting from HPK-1 overexpression...
  4. Larson C, Sandoz K, Cockrell D, Heinzen R. Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole. MBio. 2019;10: pubmed publisher
    ..deprivation promotes autophagy and lysosome fusion, as well as activation of the transcription factors TFE3 and TFEB (TFE3/B), which upregulates expression of lysosomal genes. Here, we report that C...
  5. Santos Llamas A, Monte M, Marin J, Perez M. Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine. Arch Toxicol. 2018;92:2109-2118 pubmed publisher
    ..degradation as indicated by decreases in the lysosome abundance (LAMP2 marker) and the transcription factor TFEB controlling lysosome biogenesis...
  6. Shang P, Valapala M, Grebe R, Hose S, Ghosh S, Bhutto I, et al. The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling. Aging Cell. 2017;16:349-359 pubmed publisher
    ..KO (knockout) mice, where PAT4 and amino acid levels are increased in the RPE, the transcription factors EB (TFEB) and E3 (TFE3) are retained in the cytoplasm, even after 24 h of fasting...
  7. Sekar P, Huang D, Hsieh S, Chang S, Lin W. AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia. Cell Commun Signal. 2018;16:83 pubmed publisher
    ..Interestingly, we found that P2X7 activation induced nuclear translocation of TFEB via an AMPK-dependent pathway and led to lysosomal biogenesis...
  8. Santin Y, Sicard P, Vigneron F, Guilbeau Frugier C, Dutaur M, Lairez O, et al. Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure. Antioxid Redox Signal. 2016;25:10-27 pubmed publisher
    ..D and Lamp1, reduced lysosomal acidification, and blocked the nuclear translocation of transcription factor-EB (TFEB), a master regulator of autophagy and lysosome biogenesis...
  9. Li F, Lang F, Zhang H, Xu L, Wang Y, Hao E. Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice. Oxid Med Cell Longev. 2016;2016:5380319 pubmed publisher
    ..However, a significant age dependent decline in autophagy was observed. Translocation of Transcription Factor EB (TFEB) to nucleus and formation of LC3-II were significantly reduced in LPS administered aged mice ..
  10. Kaneko H, Kobayashi M, Mizunoe Y, Yoshida M, Yasukawa H, Hoshino S, et al. Taurine is an amino acid with the ability to activate autophagy in adipocytes. Amino Acids. 2018;50:527-535 pubmed publisher
    ..Moreover, taurine-induced nuclear translocation of transcription factor EB (TFEB), a master regulator of autophagy- and lysosome-related factors...
  11. Holler C, Taylor G, McEachin Z, Deng Q, Watkins W, Hudson K, et al. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Mol Neurodegener. 2016;11:46 pubmed publisher
    ..intracellular and secreted PGRN in both mouse and human cell lines and this effect was independent of the transcription factor EB (TFEB)...
  12. Qian Q, Zhang Z, Li M, Savage K, Cheng D, Rauckhorst A, et al. Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
    ..lysosomal nitrosative stress in the livers of DIO mice, promotes lysosomal biogenesis by activating transcription factor EB (TFEB), and enhances lysosomal function and autophagy...
  13. Sauvat A, Chen G, Müller K, Tong M, Aprahamian F, Durand S, et al. Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. EBioMedicine. 2018;30:261-272 pubmed publisher
    ..puncta, production of phosphatidylinositol-3-phosphate, and activation of the transcription factor TFEB. When combined effects were assessed, several trans-unsaturated fatty acids including elaidic acid (the trans-..
  14. Tseng H, Vong C, Kwan Y, Lee S, Hoi M. Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1? Secretion via Transcription Factor EB in Human Monocytic Cells. Front Immunol. 2017;8:1161 pubmed publisher
    ..This involved calcineurin/transcription factor EB (TFEB) pathway and its target genes, cathepsin B, cathepsin D, and LAMP-1, to mediate lysosomal ..
  15. Zhang J, He J, Johnson J, Napolitano G, Ramadass M, Rahman F, et al. Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. Autophagy. 2019;: pubmed publisher
    ..of the UNC13D-binding proteins and autophagy regulators, RAB11 or VAMP8, but was caused, at least in part, by TFEB-mediated upregulation of a subset of autophagic and lysosomal genes, including Atg9b...
  16. Zhang N, Liu X, Liu L, Deng Z, Zeng Q, Pang W, et al. Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma. Cell Death Dis. 2018;9:230 pubmed publisher
    ..of the lysosome-dependent c-FLIPL degradation was associated with nuclear translocation of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis...
  17. Martina J, Diab H, Lishu L, Jeong A L, Patange S, Raben N, et al. The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci Signal. 2014;7:ra9 pubmed publisher
    The discovery of a gene network regulating lysosomal biogenesis and its transcriptional regulator transcription factor EB (TFEB) revealed that cells monitor lysosomal function and respond to degradation requirements and environmental ..
  18. Jiang Y, Jiao Y, Wang Z, Li T, Liu Y, Li Y, et al. Sinomenine Hydrochloride Inhibits Human Glioblastoma Cell Growth through Reactive Oxygen Species Generation and Autophagy-Lysosome Pathway Activation: An In Vitro and In Vivo Study. Int J Mol Sci. 2017;18: pubmed publisher
    ..Additionally, SH treatment may promote lysosome biogenesis through activating transcription factor EB (TFEB)...
  19. Ploper D, Taelman V, Robert L, Perez B, Titz B, Chen H, et al. MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells. Proc Natl Acad Sci U S A. 2015;112:E420-9 pubmed publisher
    ..the melanoma oncogene MITF (micropthalmia-associated transcription factor) and the lysosomal master regulator TFEB, had the highest phylogenetic conservation of three consecutive putative GSK3 phosphorylation sites in animal ..
  20. He L, Weber K, Diwan A, Schilling J. Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism. J Leukoc Biol. 2016;100:1113-1124 pubmed
    ..Inhibition of mTOR also triggered nuclear localization of TFEB, a transcription factor that regulates lysosome biogenesis and function, but the rescue phenotype did not require ..
  21. Choi J, Jo S. KDM7A histone demethylase mediates TNF-?-induced ICAM1 protein upregulation by modulating lysosomal activity. Biochem Biophys Res Commun. 2016;478:1355-62 pubmed publisher
    ..We also found that the transcription factor EB protein level reduced in response to TNF-? but increased by the KDM7A knockdown...
  22. Schilling J, Machkovech H, He L, Diwan A, Schaffer J. TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway. J Immunol. 2013;190:1285-96 pubmed publisher
    ..Overexpression of the transcription factor TFEB, which induces a lysosomal biogenic program, rescued the lysosomal phenotype and improved viability in palmitate- ..
  23. Shin H, Kim H, Oh S, Lee J, Kee M, Ko H, et al. AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy. Nature. 2016;534:553-7 pubmed publisher
    ..that CARM1 exerts transcriptional co-activator function on autophagy-related and lysosomal genes through transcription factor EB (TFEB)...
  24. Gianfranceschi G, Caragnano A, Piazza S, Manini I, Ciani Y, Verardo R, et al. Critical role of lysosomes in the dysfunction of human Cardiac Stem Cells obtained from failing hearts. Int J Cardiol. 2016;216:140-50 pubmed publisher
    ..genes were part of CLEAR (Coordinated Lysosomal Expression and Regulation) gene network, by which Transcription Factor EB (TFEB) regulates cellular clearance...
  25. Lina T, Luo T, Velayutham T, Das S, McBride J. Ehrlichia Activation of Wnt-PI3K-mTOR Signaling Inhibits Autolysosome Generation and Autophagic Destruction by the Mononuclear Phagocyte. Infect Immun. 2017;85: pubmed publisher
    ..induced lysosomal fusion with ehrlichial inclusions corresponding to p62 degradation and promoted transcription factor EB (TFEB) nuclear localization. E...
  26. Angelini C, Nascimbeni A, Cenacchi G, Tasca E. Lipolysis and lipophagy in lipid storage myopathies. Biochim Biophys Acta. 2016;1862:1367-73 pubmed publisher
    ..We studied in muscle regulators of lipophagy, the expression of the transcription factor-EB (TFEB) (a master regulator of lysosomal biogenesis), and markers of autophagy which are induced by starvation and exert a ..
  27. Xiong J, Zhu M. Regulation of lysosomal ion homeostasis by channels and transporters. Sci China Life Sci. 2016;59:777-91 pubmed publisher
    ..target of rapamycin (mTOR) and transcriptional regulation through calcium signaling molecules such as transcription factor EB (TFEB) and calcineurin...
  28. Classe M, Malouf G, Su X, Yao H, Thompson E, Doss D, et al. Incidence, clinicopathological features and fusion transcript landscape of translocation renal cell carcinomas. Histopathology. 2017;70:1089-1097 pubmed publisher
    ..is a rare subtype of kidney tumour characterized by translocations involving the transcription factor TFE3 or TFEB. tRCC was introduced into the World Health Organization classification in 2004, but much is still unknown about the ..
  29. Seok S, Fu T, Choi S, Li Y, Zhu R, Kumar S, et al. Transcriptional regulation of autophagy by an FXR-CREB axis. Nature. 2014;516:108-11 pubmed publisher
    ..Mechanistically, CREB upregulated autophagy genes, including Atg7, Ulk1 and Tfeb, by recruiting the coactivator CRTC2...
  30. Parks A, Charest Morin X, Boivin Welch M, Bouthillier J, Marceau F. Autophagic flux inhibition and lysosomogenesis ensuing cellular capture and retention of the cationic drug quinacrine in murine models. Peerj. 2015;3:e1314 pubmed publisher
    ..h, immunoblots), a response that follows the nuclear translocation of the lysosomal genesis transcription factor TFEB and upregulation of LAMP1 and -2 mRNAs (24 h)...
  31. Jebbink J, Boot R, Keijser R, Moerland P, Aten J, Veenboer G, et al. Increased glucocerebrosidase expression and activity in preeclamptic placenta. Placenta. 2015;36:160-9 pubmed publisher
    ..There are 89 transcripts that are negatively correlated with GBA expression of which BMP4 and TFEB are interesting as they are essential to early placenta function...
  32. Kane M, Paris A, Codron P, Cassereau J, Procaccio V, Lenaers G, et al. Current mechanistic insights into the CCCP-induced cell survival response. Biochem Pharmacol. 2018;148:100-110 pubmed publisher
    ..of two major pathways involving the signaling of the nuclear factor erythroid 2-related factor 2 (Nrf2) and the transcription factor EB (TFEB), and discuss the contribution of these pathways to the integrated cellular stress response.
  33. Magalhaes J, Gegg M, Migdalska Richards A, Schapira A. Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons. Sci Rep. 2018;8:1385 pubmed publisher
    ..b>Transcription factor EB (TFEB), the master regulator of the CLEAR pathway involved in lysosomal biogenesis was also increased ..
  34. Chu H, Wang W, Chen X, Jiang Y, Cheng R, Qi X, et al. Bafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy. Cancer Lett. 2018;423:105-112 pubmed publisher
    ..we found that cisplatin resistance of TSCC cells was related to cisplatin inducing lysosome biogenesis in a TFEB-dependent manner, which was regulated by c-Abl...
  35. Siddiqui A, Bhaumik D, Chinta S, Rane A, Rajagopalan S, Lieu C, et al. Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin. J Neurosci. 2015;35:12833-44 pubmed publisher
    ..peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) and the lysosomal regulator transcription factor EB (TFEB)...
  36. Kobayashi T, Tsutsui H, Shimabukuro Demoto S, Yoshida Sugitani R, Karyu H, Furuyama Tanaka K, et al. Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells. Int Immunol. 2017;29:551-566 pubmed publisher
    ..secretory-granule homeostasis, and limits mast-cell functions and inflammatory responses by controlling the mTORC1-TFEB signaling axis...
  37. Fan Y, Lu H, Liang W, Garcia Barrio M, Guo Y, Zhang J, et al. Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis. Circ Res. 2018;122:945-957 pubmed publisher
    ..i>TFEB (transcription factor EB) is emerging as a master gene for autophagy and lysosome biogenesis...
  38. Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, et al. Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma. Blood. 2017;129:1768-1778 pubmed publisher
    ..In the screen, TFEB (master transcriptional regulator of lysosomal biogenesis) and endosomal/lysosomal genes CLCN7, OSTM1<..
  39. Wu M, Gibbons J, DeLoid G, Bedugnis A, Thimmulappa R, Biswal S, et al. Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2017;313:L138-L153 pubmed publisher
    ..Transcription factor analysis also indicated a role for transcription factor E-box (TFEB) in MARCO recovery. Overexpression of TFEB in THP-1 cells led to marked increases in MARCO...
  40. Kauffman E, Ricketts C, Rais Bahrami S, Yang Y, Merino M, Bottaro D, et al. Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers. Nat Rev Urol. 2014;11:465-75 pubmed publisher
    Despite nearly two decades passing since the discovery of gene fusions involving TFE3 or TFEB in sporadic renal cell carcinoma (RCC), the molecular mechanisms underlying the renal-specific tumorigenesis of these genes remain largely ..
  41. Peña K, Kiselyov K. Transition metals activate TFEB in overexpressing cells. Biochem J. 2015;470:65-76 pubmed publisher
    ..b>Transcription factor EB (TFEB) regulates lysosomal biogenesis and the expression of lysosomal proteins in response to lysosomal ..
  42. Jang Y, Kwon I, Song W, Cosio Lima L, Lee Y. Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson's Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy. Neuroscience. 2018;379:292-301 pubmed publisher
    ..GPX1/2, HO-1, DJ1 and PRXIII); and (4) enhanced autophagy (LC3 II, p62, BECLIN1, BNIP3, LAMP2, CATHEPSIN L and TFEB)...
  43. Kilpatrick K, Zeng Y, Hancock T, Segatori L. Genetic and chemical activation of TFEB mediates clearance of aggregated α-synuclein. PLoS ONE. 2015;10:e0120819 pubmed publisher
    ..In this study, we investigated the role of transcription factor EB (TFEB), a master regulator of the autophagy-lysosomal pathway, in preventing the accumulation of α-syn ..
  44. Ploper D, De Robertis E. The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis. Pharmacol Res. 2015;99:36-43 pubmed publisher
    ..Other MiT members, TFEB and TFE3, are known to play important roles in cellular clearance pathways by transcriptionally regulating the ..
  45. Zhang Z, Wang H, Ding Q, Xing Y, Xu D, Xu Z, et al. The tumor suppressor p53 regulates autophagosomal and lysosomal biogenesis in lung cancer cells by targeting transcription factor EB. Biomed Pharmacother. 2017;89:1055-1060 pubmed publisher
    ..b>Transcription factor EB (TFEB) is a master transcriptional factor in the regulation of autophagy-lysosome pathway (ALP), and it ..
  46. Poirot M, Silvente Poirot S. The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers. Biochem Pharmacol. 2018;153:75-81 pubmed publisher
    ..These genes include NR4A1, NR4A3, LC3 and TFEB. The canonical LXR ligands 22(R)hydroxycholesterol, TO901317 and GW3965 did not induce these effects indicating ..
  47. Chen Y, Liu H, Guan Y, Wang Q, Zhou F, Jie L, et al. The altered autophagy mediated by TFEB in animal and cell models of amyotrophic lateral sclerosis. Am J Transl Res. 2015;7:1574-87 pubmed
    ..b>TFEB is a recently described gene that regulates autophagy...
  48. Smiles W, Parr E, Coffey V, Lacham Kaplan O, Hawley J, Camera D. Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy. Am J Physiol Endocrinol Metab. 2016;311:E836-E849 pubmed publisher
    ..05). In contrast, increases in the nuclear content of p53, TFEB, and PGC-1α in ALC-PRO were accompanied by markers of mitochondrial biogenesis at the transcriptional (Tfam, ..
  49. Petri R, Pircs K, Jönsson M, Akerblom M, Brattås P, Klussendorf T, et al. let-7 regulates radial migration of new-born neurons through positive regulation of autophagy. EMBO J. 2017;36:1379-1391 pubmed publisher
    ..This phenotype was accompanied by a decrease in autophagic activity. Overexpression of Beclin-1 or TFEB in new-born neurons lacking let-7 resulted in re-activation of autophagy and restored radial migration...
  50. She A, Kurtser I, Reis S, Hennig K, Lai J, Lang A, et al. Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia. Cell Chem Biol. 2017;24:892-906.e5 pubmed publisher
    ..Moreover, we identify regions in the GRN promoter in which elevated H3K27 acetylation and transcription factor EB (TFEB) occupancy correlate with HDAC-inhibitor-mediated upregulation of PGRN...
  51. Wang Y, Liu F, Wang Y, Guan R, Chen C, Li D, et al. Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation. Neurotox Res. 2018;34:109-120 pubmed publisher
    ..So far, the effective drugs for ALS are yet to be developed. Impairment of transcriptional activator transcription factor EB (TFEB) has been demonstrated as a key element in the pathogenesis of ALS...
  52. Najibi M, Labed S, Visvikis O, IRAZOQUI J. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016;15:1728-42 pubmed publisher
    ..We previously identified TFEB as a transcription factor important for host defense, but the mechanisms that regulate TFEB during infection ..
  53. Zhang J, Johnson J, He J, Napolitano G, Ramadass M, Rocca C, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017;292:10328-10346 pubmed publisher
    ..RILP expression was restored by up-regulation of the transcription factor EB (TFEB), which was down-regulated in cystinosis...
  54. Bento C, Ashkenazi A, Jimenez Sanchez M, Rubinsztein D. The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun. 2016;7:11803 pubmed publisher
    ..by a mechanism dependent on MYCBP2-induced ubiquitination of TSC2, which leads to mTORC1 activation and decreased TFEB-mediated transcription of SYT11, while increased protein turnover is regulated by SYT11 ubiquitination and ..
  55. Bhatelia K, Singh K, Prajapati P, Sripada L, Roy M, Singh R. MITA modulated autophagy flux promotes cell death in breast cancer cells. Cell Signal. 2017;35:73-83 pubmed publisher
    ..The enhancement of autophagy flux with rapamycin or TFEB expression normalized MITA induced cell death...
  56. Kim Y, Hood D. Regulation of the autophagy system during chronic contractile activity-induced muscle adaptations. Physiol Rep. 2017;5: pubmed publisher
    ..as represented by increases in lysosomal system markers LAMP1, LAMP2A, and MCOLN1 as early as by day 1, as well as TFEB, a primary regulator of lysosomal biogenesis and autophagy flux...
  57. Perera R, Stoykova S, Nicolay B, Ross K, Fitamant J, Boukhali M, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015;524:361-5 pubmed publisher
    ..In human PDA cells, the MiT/TFE proteins--MITF, TFE3 and TFEB--are decoupled from regulatory mechanisms that control their cytoplasmic retention...
  58. Awad O, Sarkar C, Panicker L, Miller D, Zeng X, Sgambato J, et al. Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells. Hum Mol Genet. 2015;24:5775-88 pubmed publisher
    ..Further analysis showed that in GD iPSC-NCs, expression of the transcription factor EB (TFEB), the master regulator of lysosomal genes, and lysosomal gene expression, were significantly ..
  59. Hidvegi T, Stolz D, Alcorn J, Yousem S, Wang J, Leme A, et al. Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. J Biol Chem. 2015;290:29742-57 pubmed publisher
    ..Treatment with autophagy enhancer drugs or lung-directed gene transfer of TFEB, a master transcriptional activator of the autophagolysosomal system, reversed these proteotoxic consequences...
  60. Yang X, Miao N, Gan H, Wang L, Wang C. [Clear cell papillary renal cell carcinoma: a distinct low-grade renal tumour]. Zhonghua Bing Li Xue Za Zhi. 2015;44:372-6 pubmed
    ..The staining for CD10, P504S, CD117, TFE3 and TFEB was negative...
  61. Nabar N, Kehrl J. The Transcription Factor EB Links Cellular Stress to the Immune Response??. Yale J Biol Med. 2017;90:301-315 pubmed
    The transcription factor EB (TFEB) is the master transcriptional regulator of autophagy and lysosome biogenesis...
  62. He X, Yuan W, Li Z, Hou Y, Liu F, Feng J. 6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells. Toxicol Lett. 2018;283:58-68 pubmed publisher
    ..b>Transcription factor EB (TFEB), a key transcription factor controlling lysosome biogenesis, was also significantly downregulated ..
  63. Zhu Z, Yu T, Liu H, Jin J, He J. SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation. Cell Death Dis. 2018;9:50 pubmed publisher
    ..which activated calcineurin (CaN); CaN activated the nuclear factor of activated T cells (NFAT) and transcription factor EB (TFEB), thus promoting the transcriptional activation of multiple chemokines genes and autophagy-..
  64. Magini A, Polchi A, Urbanelli L, Cesselli D, Beltrami A, Tancini B, et al. TFEB activation promotes the recruitment of lysosomal glycohydrolases ?-hexosaminidase and ?-galactosidase to the plasma membrane. Biochem Biophys Res Commun. 2013;440:251-7 pubmed publisher
    ..Recently, it has been demonstrated that lysosome response to the physiologic signals is regulated by the transcription factor EB (TFEB)...
  65. Kim Y, Park M, Eum K, Kim J, Lee J, Bae T, et al. Transcriptome analysis indicates TFEB1 and YEATS4 as regulatory transcription factors for drug resistance of ovarian cancer. Oncotarget. 2015;6:31030-8 pubmed publisher
    ..Thus, we suggest a novel approach to reverse chemoresistance of ovarian cancer by suppressing TFEB1 and YEATS4. ..
  66. Inamura K. Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features. Cancers (Basel). 2017;9: pubmed publisher
    ..Due to the presence of fusion genes, Xp11 tRCC and t(6;11) RCC are also known as TFE3- and TFEB-rearranged RCC, respectively...
  67. Bretou M, Sáez P, Sanséau D, Maurin M, Lankar D, Chabaud M, et al. Lysosome signaling controls the migration of dendritic cells. Sci Immunol. 2017;2: pubmed publisher
    ..Lysosomal calcium further induces the activation of the transcription factor EB (TFEB), which translocates to the nucleus to maintain TRPML1 expression...
  68. Zhitomirsky B, Assaraf Y. Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance. Oncotarget. 2015;6:1143-56 pubmed
    ..doxorubicin and mitoxantrone triggered rapid lysosomal biogenesis that was associated with nuclear translocation of TFEB, the dominant transcription factor regulating lysosomal biogenesis...
  69. Martina J, Puertollano R. TFEB and TFE3: The art of multi-tasking under stress conditions. Transcription. 2017;8:48-54 pubmed publisher
    ..Two transcription factors, TFEB and TFE3, have recently emerged as master regulators of this degradative pathway...
  70. Jin L, Zeng W, Zhang F, Zhang C, Liang W. Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradation. J Immunol. 2017;199:3466-3477 pubmed publisher
    ..Further studies show that naringenin enhances intracellular cytokine degradation through lysosome- and TFEB-dependent mechanisms...
  71. Xia Q, Wang X, Ye S, Wang X, Li R, Shi S, et al. Novel gene fusion of PRCC-MITF defines a new member of MiT family translocation renal cell carcinoma: clinicopathological analysis and detection of the gene fusion by RNA sequencing and FISH. Histopathology. 2018;72:786-794 pubmed publisher
    MITF, TFE3, TFEB and TFEC belong to the same microphthalmia-associated transcription factor family (MiT)...
  72. Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, et al. Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux. Autophagy. 2017;:1-56 pubmed publisher
    ..ANXA2E139A mutation in lung epithelial cells ablates bleomycin binding and activates TFEB (transcription factor EB), a master regulator of macroautophagy/autophagy, resulting in substantial acceleration of autophagic ..
  73. Parcon P, Balasubramaniam M, Ayyadevara S, Jones R, Liu L, Shmookler Reis R, et al. Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs. Alzheimers Dement. 2018;14:230-242 pubmed publisher
    ..Autophagy opposes aggregation, and important autophagy genes are coordinately regulated by transcription factor EB (TFEB) binding to "coordinated lysosomal expression and regulation" (CLEAR) DNA motifs...
  74. Kuo C, Hansen M, Troemel E. Autophagy and innate immunity: Insights from invertebrate model organisms. Autophagy. 2017;: pubmed publisher
    ..first to show xenophagic targeting of microsporidia, a fungal pathogen that infects all animals, and to identify TFEB/HLH-30, a helix-loop-helix transcription factor, as an evolutionarily conserved regulator of autophagy gene ..
  75. Martina J, Diab H, Brady O, Puertollano R. TFEB and TFE3 are novel components of the integrated stress response. EMBO J. 2016;35:479-95 pubmed publisher
    ..The participation of the transcription factors TFEB and TFE3 in cellular adaptation to starvation is well established...
  76. Rocchi A, Milioto C, Parodi S, Armirotti A, Borgia D, Pellegrini M, et al. Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet. Acta Neuropathol. 2016;132:127-44 pubmed publisher
    ..At later stages of disease, we detected mitochondrial membrane depolarization, enhanced transcription factor EB (TFEB) expression and autophagy, and mTOR-induced protein synthesis...
  77. Vega Rubin de Celis S, Peña Llopis S, Konda M, Brugarolas J. Multistep regulation of TFEB by MTORC1. Autophagy. 2017;13:464-472 pubmed publisher
    The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A mutation increases nuclear localization...
  78. Argani P, Lae M, Hutchinson B, Reuter V, Collins M, Perentesis J, et al. Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol. 2005;29:230-40 pubmed
    ..translocation recently been shown to result in fusion of Alpha, a gene on 11q12, with the transcription factor gene TFEB on 6p21...
  79. Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, et al. Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis. J Neurosci. 2015;35:12137-51 pubmed publisher
    ..function as a driver of increased amyloidogenic processing of APP, we explored the efficacy of targeting transcription factor EB (TFEB), a master regulator of lysosomal pathways, to reduce Aβ levels...
  80. Bao J, Zheng L, Zhang Q, Li X, Zhang X, Li Z, et al. Deacetylation of TFEB promotes fibrillar A? degradation by upregulating lysosomal biogenesis in microglia. Protein Cell. 2016;7:417-33 pubmed publisher
    ..We tested whether enhancing lysosomal function with transcription factor EB (TFEB), an essential regulator modulating lysosomal pathways, would promote A? clearance in microglia...
  81. Wang H, Wang R, Carrera I, Xu S, Lakshmana M. TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits. Eneuro. 2016;3: pubmed publisher
    b>Transcription factor EB (TFEB) was recently shown to be a master regulator of autophagy lysosome pathway. Here, we successfully generated and characterized transgenic mice overexpressing flag-TFEB...
  82. Gatto F, Rossi B, Tarallo A, Polishchuk E, Polishchuk R, Carrella A, et al. AAV-mediated transcription factor EB (TFEB) gene delivery ameliorates muscle pathology and function in the murine model of Pompe Disease. Sci Rep. 2017;7:15089 pubmed publisher
    ..We previously showed that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor EB (TFEB) gene was effective in improving muscle pathology in PD mice injected intramuscularly with an AAV-..
  83. Wu B, Tan M, Cai W, Wang B, He P, Zhang X. Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018;496:167-175 pubmed publisher
    ..Mechanistically, ATO induced TFEB(Ser142) dephosphorylation, activated TFEB nuclear translocation and increased TFEB reporter activity, ..
  84. Cortes C, Miranda H, Frankowski H, Batlevi Y, Young J, Le A, et al. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nat Neurosci. 2014;17:1180-9 pubmed publisher
    ..regulation of autophagy and observed a functionally significant physical interaction between transcription factor EB (TFEB) and AR. Normal AR promoted, but polyQ-AR interfered with, TFEB transactivation...
  85. Giatromanolaki A, Kalamida D, Sivridis E, Karagounis I, Gatter K, Harris A, et al. Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer. Lung Cancer. 2015;90:98-105 pubmed publisher
    ..Using immunohistochemistry we investigated the expression of the transcription factor EB (TFEB) which orchestrates lysosomal biogenesis, the lysosome membrane protein LAMP2a and of the lysosomal ..
  86. Pastore N, Brady O, Diab H, Martina J, Sun L, Huynh T, et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy. 2016;12:1240-58 pubmed publisher
    ..In this study we identify a critical and complementary role of the transcription factors TFEB and TFE3 in innate immune response...
  87. Davis I, Hsi B, Arroyo J, Vargas S, Yeh Y, Motyckova G, et al. Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc Natl Acad Sci U S A. 2003;100:6051-6 pubmed
    MITF, TFE3, TFEB, and TFEC comprise a transcription factor family (MiT) that regulates key developmental pathways in several cell lineages. Like MYC, MiT members are basic helix-loop-helix-leucine zipper transcription factors...
  88. Peckova K, Vanecek T, Martinek P, Spagnolo D, Kuroda N, Brunelli M, et al. Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature. Ann Diagn Pathol. 2014;18:351-7 pubmed publisher
    ..Translocation t(6;11)(Alpha-TFEB) or TFEB break was detected in 4 of 5 NATs and in the AT case. Aggressive tumor showed amplification of TFEB locus...
  89. Nezich C, Wang C, Fogel A, Youle R. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015;210:435-50 pubmed publisher
    ..Because of the demand on lysosomal function by mitophagy, we investigated a role for the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in this process...
  90. Li C, Yu L, Xue H, Yang Z, Yin Y, Zhang B, et al. Nuclear AMPK regulated CARM1 stabilization impacts autophagy in aged heart. Biochem Biophys Res Commun. 2017;486:398-405 pubmed publisher
    ..The CARM1 stabilization is markedly decrease in aged hearts, which impaired nucleus TFEB-CARM1 complex and autophagy flux...
  91. Kim S, Kim G, Han D, Lee M, Kim I, Kim B, et al. Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition. Autophagy. 2017;13:1767-1781 pubmed publisher
    ..Human livers with steatosis or NASH presented impaired autophagy with decreased nuclear TFEB and increased SQSTM1, MAP1LC3-II, and NLRP3 expression...
  92. Murano T, Najibi M, Paulus G, Adiliaghdam F, Valencia Guerrero A, Selig M, et al. Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. Sci Rep. 2017;7:13938 pubmed publisher
    ..Recently, transcription factor EB (TFEB) was implicated in expression of autophagy and host defense genes in nematodes and mammalian cells...