Gene Symbol: TFDP2
Description: transcription factor Dp-2
Alias: DP2, transcription factor Dp-2, transcription factor Dp-2 (E2F dimerization partner 2)
Species: human
Products:     TFDP2

Top Publications

  1. Basu S, Shankar V, Yudkin J. Comparative effectiveness and cost-effectiveness of treat-to-target versus benefit-based tailored treatment of type 2 diabetes in low-income and middle-income countries: a modelling analysis. Lancet Diabetes Endocrinol. 2016;4:922-932 pubmed publisher
    ..Rosenkranz Prize for Healthcare Research in Developing Countries and US National Institutes of Health (U54 MD010724, DP2 MD010478).
  2. Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe A, et al. DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment. Sci Transl Med. 2019;11: pubmed publisher
    ..Fevipiprant may thus represent a potential therapy to ameliorate airway remodeling in asthma. ..
  3. Lim S, Shin J, Cho Y, Kim K. Dietary Patterns Associated with Sebum Content, Skin Hydration and pH, and Their Sex-Dependent Differences in Healthy Korean Adults. Nutrients. 2019;11: pubmed publisher
    ..Among the four DPs extracted from the FFQ, DP2, characterized by a high intake of cereals, potatoes and starch, saccharides and fish and shellfish, was negatively ..
  4. Granic A, Mendonça N, Sayer A, Hill T, Davies K, Siervo M, et al. Effects of dietary patterns and low protein intake on sarcopenia risk in the very old: The Newcastle 85+ study. Clin Nutr. 2019;: pubmed publisher
    ..We identified three DPs (DP1: 'Low Red Meat', DP2: 'Traditional British' and DP3: 'Low Butter') that varied by unsaturated fat spreads/oils, butter, red meat, gravy ..
  5. Mittal M, Jain S, Sun S, deBeck K, Milloy M, Hayashi K, et al. Opioid agonist treatment and the process of injection drug use initiation. Drug Alcohol Depend. 2019;197:354-360 pubmed publisher
    ..Preventing Injecting by Modifying Existing Responses (PRIMER; NIDA DP2-DA040256-01) is a prospective multi-cohort study seeking to identify structural interventions that reduce the risk ..
  6. Elhassanny A, Ladin D, Soliman E, Albassam H, Morris A, Kobet R, et al. Prostaglandin D2-ethanolamide induces skin cancer apoptosis by suppressing the activity of cellular antioxidants. Prostaglandins Other Lipid Mediat. 2019;142:9-23 pubmed publisher
    ..The effect of PGD2-EA was independent of DP1, DP2, and PPARγ receptors suggesting that PGD2-EA cytotoxicity was mediated by its metabolic product, 15dPGJ<..
  7. Petpiroon N, Bhummaphan N, Tungsukruthai S, Pinkhien T, Maiuthed A, Sritularak B, et al. Chrysotobibenzyl inhibition of lung cancer cell migration through Caveolin-1-dependent mediation of the integrin switch and the sensitization of lung cancer cells to cisplatin-mediated apoptosis. Phytomedicine. 2019;58:152888 pubmed publisher
    ..lung cancer cells (H460, H292, A549, and H23) and other non-cancerous human cells (HCT116, primary DP1 and primary DP2). However, 50 µM of chrysotobibenzyl significantly altered cell proliferation in H292 cells at 48 h...
  8. Huang Y, Mao Y, Buczek Thomas J, Nugent M, Zaia J. Oligosaccharide substrate preferences of human extracellular sulfatase Sulf2 using liquid chromatography-mass spectrometry based glycomics approaches. PLoS ONE. 2014;9:e105143 pubmed publisher
    ..HSulf2 digestion induced more sulfation decrease on DP6 (DP: degree of polymerization) compared to DP2, DP4 and DP8...
  9. Snell N, Foster M, Vestbo J. Efficacy and safety of AZD1981, a CRTH2 receptor antagonist, in patients with moderate to severe COPD. Respir Med. 2013;107:1722-30 pubmed publisher
    To evaluate the efficacy and tolerability of the selective CRTh2 (DP2) receptor antagonist AZD1981 compared with placebo in patients with moderate to severe COPD...

More Information

Publications117 found, 100 shown here

  1. Chavan B, Sawant V, Borkar R, Ragampeta S, Talluri M. Isolation and structural characterization of degradation products of afatinib dimaleate by LC-Q-TOF/MS/MS and NMR: cytotoxicity evaluation of afatinib and isolated degradation products. J Pharm Biomed Anal. 2019;166:139-146 pubmed publisher
    ..Two major degradation products (DP2 and DP3) were isolated using preparative HPLC and their structures were confirmed by conducting 1H and <..
  2. Luker T, Bonnert R, Brough S, Cook A, Dickinson M, Dougall I, et al. Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. Bioorg Med Chem Lett. 2011;21:6288-92 pubmed publisher
    ..selective antagonists of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2)...
  3. Scherer N, Marcseková K, Posset T, Winter G. New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics. Int J Pharm. 2019;555:404-419 pubmed publisher
    ..274 ppm < drug specific threshold: 6.0 ppm | DP2: 0.010 ppm < 0.2 ppm | DP3: 0.011 ppm < 0.5 ppm)...
  4. Jang D, Levy P, Shofer F, Sun B, Brown J. A comparative analysis of National Institutes of Health research support for emergency medicine - 2008 to 2017. Am J Emerg Med. 2018;: pubmed publisher
    ..Research Grants were defined by the following activity codes: R, P, M, S, K, U (excluding UC6), DP1, DP2, DP3, DP4, DP5, D42 and G12...
  5. Schmidt J, Bell F, Akam E, Marshall C, Dainty I, Heinemann A, et al. Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. Br J Pharmacol. 2013;168:1626-38 pubmed publisher
    The discovery of DP2 as a second receptor for PGD2 has prompted the search for antagonists as potential novel therapies based on the associations between PGD2 and disease...
  6. Dai S, Murphy G, Crawford F, Mack D, Falta M, Marrack P, et al. Crystal structure of HLA-DP2 and implications for chronic beryllium disease. Proc Natl Acad Sci U S A. 2010;107:7425-30 pubmed publisher
    ..The structure of HLA-DP2 and its interaction with Be are unknown...
  7. Clayton G, Wang Y, Crawford F, Novikov A, Wimberly B, Kieft J, et al. Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell. 2014;158:132-42 pubmed publisher
    ..Individuals carrying the MHCII allele, HLA-DP2, are at risk for chronic beryllium disease (CBD), a debilitating inflammatory lung condition caused by the reaction ..
  8. Takashima N, Ishino S, Oki K, Takafuji M, Yamagami T, Matsuo R, et al. Elucidating functions of DP1 and DP2 subunits from the Thermococcus kodakarensis family D DNA polymerase. Extremophiles. 2019;23:161-172 pubmed publisher
    ..PolD is composed of two proteins: DP1 and DP2. To date, the 3D structure of the PolD heteromeric complex is yet to be determined...
  9. Baira S, Kalariya P, Nimbalkar R, Garg P, Srinivas R, Talluri M. Characterization of forced degradation products of canagliflozine by liquid chromatography/quadrupole time-of-flight tandem mass spectrometry and in silico toxicity predictions. Rapid Commun Mass Spectrom. 2018;32:212-220 pubmed publisher
    ..CAN was found to degrade under oxidative stress condition and formed DP1 and DP2. This is a typical case of degradation where co-solvents acetonitrile-water (50:50, v/v) and methanol-water (50:50, ..
  10. Jeddou K, Bouaziz F, Helbert C, Nouri Ellouz O, Maktouf S, Ellouz Chaabouni S, et al. Structural, functional, and biological properties of potato peel oligosaccharides. Int J Biol Macromol. 2018;112:1146-1155 pubmed publisher
    ..fractions OPPP3, OPPP4, OPPP5, OPPP6 and OPPP7 were compose of the following degree of polymerization DP5; DP4; DP2; DP1 and DP1, respectively...
  11. Yazbeck R, Sulda M, Howarth G, Bleich A, Raber K, von Horsten S, et al. Dipeptidyl peptidase expression during experimental colitis in mice. Inflamm Bowel Dis. 2010;16:1340-51 pubmed publisher
    ..DP8 and DP2 mRNA levels were increased (P < 0.05) in WT+saline mice compared to untreated WT mice with colitis...
  12. Corwin C, Nikolopoulou A, Pan A, Nunez Santos M, Vallabhajosula S, Serrano P, et al. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. J Neuroinflammation. 2018;15:272 pubmed publisher
    ..of unilateral nigral PGJ2-microinfusions on COX-2, lipocalin-type PGD2 synthase (L-PGDS), PGD2/J2 receptor 2 (DP2), and 15 hydroxyprostaglandin dehydrogenase (15-PGDH)...
  13. Wang G, Ji J, El Kasmi F, Dangl J, Johal G, Balint Kurti P. Molecular and functional analyses of a maize autoactive NB-LRR protein identify precise structural requirements for activity. PLoS Pathog. 2015;11:e1004674 pubmed publisher
    ..The maize NLR gene Rp1-D21 derives from an intergenic recombination event between two NLR genes, Rp1-D and Rp1-dp2 and confers an autoactive HR...
  14. Werder R, Lynch J, Simpson J, Zhang V, Hodge N, Poh M, et al. PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production. Sci Transl Med. 2018;10: pubmed publisher
    Prostaglandin D2 (PGD2) signals through PGD2 receptor 2 (DP2, also known as CRTH2) on type 2 effector cells to promote asthma pathogenesis; however, little is known about its role during respiratory syncytial virus (RSV) bronchiolitis, a ..
  15. Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford A, et al. Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes. Sci Rep. 2018;8:8438 pubmed publisher
    ..ectopic E2F1- or adenovirus E1a-induced expression of the CDC6 gene and cell proliferation, knockdown of DP1 and DP2 expression did not affect ectopic E2F1- or E1a-induced expression of the tumor suppressor ARF gene, an upstream ..
  16. Yaman M, Yarılgaç E, Güner B, Ertürk Ã. [Presence of Nosemosis in Honeybees (Apis mellifera) in Ordu Province]. Turkiye Parazitol Derg. 2015;39:47-51 pubmed publisher
    ..disease factors were measured and photographed using an Olympus BX51 microscope with a DP-25 digital camera and a DP2-BSW Soft Imaging System. Nosemosis was observed in all examined localities...
  17. Maher S, Birrell M, Adcock J, Wortley M, Dubuis E, Bonvini S, et al. Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events. Eur Respir J. 2015;45:1108-18 pubmed publisher
    ..Although the prostaglandin D2 receptor 2 (DP2) is a target for numerous drug discovery programmes little is known about the actions of PGD2 on sensory nerves and ..
  18. Wade M, Collins M, Richards D, Mack D, Martin A, Dinarello C, et al. TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization. J Immunol. 2018;201:2232-2243 pubmed publisher
    ..death/release of IL-1α and DNA, enhanced migration of CD80hi DCs to the LDLNs, and sensitized HLA-DP2 transgenic mice after single low-dose exposures, whereas exposures to insoluble particulate forms beryllium did not...
  19. Joseph P, Mosier P, Desai U, Rajarathnam K. Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions. Biochem J. 2015;472:121-33 pubmed publisher
    ..these issues, we characterized the binding of a series of heparin-derived oligosaccharides [heparin disaccharide (dp2), heparin tetrasaccharide (dp4), heparin octasaccharide (dp8) and heparin 14-mer (dp14)] to the wild-type (WT) ..
  20. Li Q, Li G, Zhao X, Shan X, Cai C, Zhao J, et al. Structural Characterization and Interaction with RCA120 of a Highly Sulfated Keratan Sulfate from Blue Shark (Prionace glauca) Cartilage. Mar Drugs. 2018;16: pubmed publisher
    ..Furthermore, KSO from dp2 to dp8 bound to RCA120 in the increasing trend while the binding affinity of dp8 was superior to ..
  21. Tolonen L, Juvonen M, Niemelä K, Mikkelson A, Tenkanen M, Sixta H. Supercritical water treatment for cello-oligosaccharide production from microcrystalline cellulose. Carbohydr Res. 2015;401:16-23 pubmed publisher
    ..The highest yield of 42 wt% for DP2-9 cello-oligosaccharides was achieved after the 0.4s treatment...
  22. Tao X, Wang L, Gao W, Ding J, Feng X, Zhou Z, et al. The Effect of Inducible Nitric Oxide Synthase on Multiterritory Perforator Flap Survival in Rats. J Reconstr Microsurg. 2016;32:643-649 pubmed
    ..On postoperative day 7, the surviving flap area was calculated as a percentage of the total flap dimensions using DP2-BSW software...
  23. Wang J, Woodward D, Martos J, Cornell C, Carling R, Kingsley P, et al. Multitargeting of selected prostanoid receptors provides agents with enhanced anti-inflammatory activity in macrophages. FASEB J. 2016;30:394-404 pubmed publisher
    ..a prototype compound, compound 1 (AGN 211377), that antagonizes prostaglandin D2 receptors (DPs) DP1 (49) and DP2 (558), prostaglandin E2 receptors (EPs) EP1 (266) and EP4 (117), prostaglandin F2α receptor (FP) (61), and ..
  24. Kumar S, Palaia T, Hall C, Ragolia L. Role of Lipocalin-type prostaglandin D2 synthase (L-PGDS) and its metabolite, prostaglandin D2, in preterm birth. Prostaglandins Other Lipid Mediat. 2015;118-119:28-33 pubmed publisher
    ..L-PGDS (+/+), L-PGDS (-/-) and C57BL/6 control pregnant mice models were used to determine the effect of DP1 and DP2 receptor antagonists in lipopolysaccharide (LPS)-induced PTB mice...
  25. Takahashi G, Asanuma F, Suzuki N, Hattori M, Sakamoto S, Kugimiya A, et al. Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma. Eur J Pharmacol. 2015;765:15-23 pubmed publisher
    Prostaglandin (PG) D2 elicits responses through either the DP1 and/or DP2 receptor...
  26. Mahdavi M, Moreau V. In silico designing breast cancer peptide vaccine for binding to MHC class I and II: A molecular docking study. Comput Biol Chem. 2016;65:110-116 pubmed publisher
    ..The GOLD results predicted HLA-DR4, HLA-DP2 and TCR as the most often targeted receptors by the peptide 1412...
  27. Kumar K, Correia M, Pires V, Dhillon A, Sharma K, Rajulapati V, et al. Novel insights into the degradation of β-1,3-glucans by the cellulosome of Clostridium thermocellum revealed by structure and function studies of a family 81 glycoside hydrolase. Int J Biol Macromol. 2018;117:890-901 pubmed publisher
    ..hydrolysed products released initially, showed β-1,3-glucan-oligosaccharides degree of polymerization (DP) from DP2 to DP7, confirming an endo-mode of action...
  28. Zhuo R, Yu H, Qin X, Ni H, Jiang Z, Ma F, et al. Heterologous expression and characterization of a xylanase and xylosidase from white rot fungi and their application in synergistic hydrolysis of lignocellulose. Chemosphere. 2018;212:24-33 pubmed publisher
    ..MALDI-TOF-MS and HPLC analysis showed that xylooligosaccharides (XOS) with small degrees of polymerization (DP2-DP4) were the major XOS hydrolyzate during SHPC degradation by rXyn162 and rXylCD2...
  29. Boger M, Lammerts van Bueren A, Dijkhuizen L. Cross-Feeding among Probiotic Bacterial Strains on Prebiotic Inulin Involves the Extracellular exo-Inulinase of Lactobacillus paracasei Strain W20. Appl Environ Microbiol. 2018;84: pubmed publisher
  30. Mack D, Falta M, McKee A, Martin A, Simonian P, Crawford F, et al. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc Natl Acad Sci U S A. 2014;111:8553-8 pubmed publisher
    Susceptibility to chronic beryllium disease (CBD) is linked to certain HLA-DP molecules, including HLA-DP2. To elucidate the molecular basis of this association, we exposed mice transgenic (Tg) for HLA-DP2 to beryllium oxide (BeO) via ..
  31. Petukh M, Wu B, Stefl S, Smith N, Hyde Volpe D, Wang L, et al. Chronic Beryllium Disease: revealing the role of beryllium ion and small peptides binding to HLA-DP2. PLoS ONE. 2014;9:e111604 pubmed publisher
    ..The CBD is caused by Be exposure of individuals carrying the HLA-DP2 protein of the major histocompatibility complex class II (MHCII)...
  32. Niu Z, Liu H, Zhou M, Wang H, Liu Y, Li X, et al. Knockdown of c-Myc inhibits cell proliferation by negatively regulating the Cdk/Rb/E2F pathway in nasopharyngeal carcinoma cells. Acta Biochim Biophys Sin (Shanghai). 2015;47:183-91 pubmed publisher
    ..of several critical molecules involved in the Cdk/Rb/E2F pathway, including CDK4, cyclin D1, CDK2, pRb, E2F3, and DP2, and significantly reduced the promoter activity of cyclin D1...
  33. Medani M, Collins D, Mohan H, Walsh E, Winter D, Baird A. Prostaglandin D2 regulates human colonic ion transport via the DP1 receptor. Life Sci. 2015;122:87-91 pubmed publisher
    ..The involvement of DP2 receptor subtypes has not previously been considered in regulation of ion transport in human intestine...
  34. Moniot B, Ujjan S, Champagne J, Hirai H, Aritake K, Nagata K, et al. Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014;141:3561-71 pubmed publisher
    ..We show that PGD2 acts through its Dp2 receptor, at least in part through direct effects in germ cells, and contributes to the proper differentiation of ..
  35. Quiroga A, Stolt C, Diez del Corral R, Dimitrov S, Pérez Alcalá S, Sock E, et al. Sox5 controls dorsal progenitor and interneuron specification in the spinal cord. Dev Neurobiol. 2015;75:522-38 pubmed publisher
    ..loss-of function approaches in chicken embryos, we have established that Sox5 controls cell fate specification of dp2 and dp3 progenitors and, as a result, controls the correct number of the corresponding dorsal interneurons (dI2 and ..
  36. Koss K, Tsui C, Unsworth L. Induced Neural Differentiation of MMP-2 Cleaved (RADA)4 Drug Delivery Systems. J Control Release. 2016;243:204-213 pubmed publisher
    ..GPQG+PAGQ (CP2), the brain-derived NTF secretion stimulating peptide MVG (DP1) and the ciliary NTF analogue DGGL (DP2)...
  37. Moon T, Campos Alberto E, Yoshimura T, Bredo G, Rieger A, Puttagunta L, et al. Expression of DP2 (CRTh2), a prostaglandin Dâ‚‚ receptor, in human mast cells. PLoS ONE. 2014;9:e108595 pubmed publisher
    PGDâ‚‚ has long been implicated in allergic diseases. Recent cloning of a second PGDâ‚‚ receptor, DP2 (also known as CRTh2), led to a greater understanding of the physiological and pathophysiological implications of PGDâ‚‚...
  38. Petrou A, Kuster D, Lee J, Meboldt M, Schmid Daners M. Comparison of Flow Estimators for Rotary Blood Pumps: An In Vitro and In Vivo Study. Ann Biomed Eng. 2018;46:2123-2134 pubmed publisher
    ..inlet and outlet pump pressure sensors are used. Data from in vitro and in vivo studies with the Deltastream pump DP2 were used to compare the estimators under the same test conditions...
  39. Trytek M, Fiedurek J, Podkościelna B, Gawdzik B, Skowronek M. An efficient method for the immobilization of inulinase using new types of polymers containing epoxy groups. J Ind Microbiol Biotechnol. 2015;42:985-96 pubmed publisher
    ..1 mL/min. A tenfold increase in the speed of flow resulted in an increase in the yield of oligosaccharides (DP2-DP6) up to ~41% in the overall hydrolysate, as analysed by HPLC-RID and LC-ESI/MS...
  40. Mittal M, Vashishtha D, Sun S, Jain S, Cuevas Mota J, Garfein R, et al. History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA. Subst Abuse Treat Prev Policy. 2017;12:42 pubmed publisher
    ..Preventing Injecting by Modifying Existing Responses (PRIMER; NIDA DP2-DA040256-01), is a multi-site cohort study assessing the impact of socio-structural factors on the risk that PWID ..
  41. Kottgen A, Pattaro C, Böger C, Fuchsberger C, Olden M, Glazer N, et al. New loci associated with kidney function and chronic kidney disease. Nat Genet. 2010;42:376-84 pubmed publisher
    ..22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine ..
  42. Yagami T, Koma H, Yamamoto Y. Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. Mol Neurobiol. 2016;53:4754-71 pubmed publisher
    ..Although PGD2 induces neuronal apoptosis after a lag time, neither DP1 nor DP2 is involved in the neurotoxicity...
  43. Fontenot A, Falta M, Kappler J, Dai S, McKee A. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol. 2016;196:22-7 pubmed publisher
    ..Recent structural analysis of a Be-specific TCR interacting with a Be-loaded HLA-DP2-peptide complex revealed that Be is coordinated by amino acid residues derived from the HLA-DP2 β-chain and ..
  44. Zhou J, Wu S, Pan Y, Zhang L, Cao Z, Zhang X, et al. Enrichment of heavy metals in fine particles of municipal solid waste incinerator (MSWI) fly ash and associated health risk. Waste Manag. 2015;43:239-46 pubmed publisher that volatile metals, such as Zn, Pb, Cu and Cd, were easily concentrated in the fine particles, especially in Dp2.5-1 and Dp1, with soluble and exchangeable substances as the main chemical species...
  45. Mitchell J, Seng A, Yankee T. Ikaros, Helios, and Aiolos protein levels increase in human thymocytes after β selection. Immunol Res. 2016;64:565-75 pubmed publisher
    ..In each group of patients, CD3(-) ISP and DP thymocytes were subdivided into ISP1, ISP2, DP1, DP2, DP3, DP4, and DP5 developmental stages according to their expression of CD28, CD44, CD1a, CD7, CD45RO, and CD38...
  46. Srivastava P, Panwar D, Prashanth K, Kapoor M. Structural Characterization and in Vitro Fermentation of ?-Mannooligosaccharides Produced from Locust Bean Gum by GH-26 endo-?-1,4-Mannanase (ManB-1601). J Agric Food Chem. 2017;65:2827-2838 pubmed publisher
    ..b>DP2 oligosaccharide was composed of two species, (A) mannopyranose ?-1,4 mannopyranose and (B) ?-1,6-galactosyl-..
  47. Mazidi M, Wong N, Katsiki N, Mikhailidis D, Banach M. Dietary patterns, plasma vitamins and Trans fatty acids are associated with peripheral artery disease. Lipids Health Dis. 2017;16:254 pubmed publisher
    ..8% of the variance in dietary nutrients consumption including DP1 (fatty acids and cholesterol), DP2 (minerals, vitamins and fiber), and DP3 (polyunsaturated fatty acids [PUFA])...
  48. Jeong K, Jung J, Kim J, Kang H. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells. Int J Mol Sci. 2018;19: pubmed publisher
    Prostaglandin D2 (PGD2) and prostaglandin D2 receptor 2 (DP2) is known to be an important factor in androgenetic alopecia (AGA). However, the effect of PGD2 in human dermal papilla cells (hDPCs) is not fully understood...
  49. Jandl K, Stacher E, Bálint Z, Sturm E, Maric J, Peinhaupt M, et al. Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung. J Allergy Clin Immunol. 2016;137:833-43 pubmed publisher
    ..mediator in inflammation, but its action and the roles of the 2 D-type prostanoid receptors (DPs) DP1 and DP2 (also called chemoattractant receptor-homologous molecule expressed on T(H)2 cells) in regulating macrophages have ..
  50. Rossi S, Windschüttl S, Matzkin M, Rey Ares V, Terradas C, Ponzio R, et al. Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells. Mol Cell Endocrinol. 2016;434:154-65 pubmed publisher
    ..We describe a stimulatory effect of PGD2 on lactate dehydrogenase (LDH) expression via DP1/DP2 receptors, which is prevented by the antioxidant N-acetyl-L-cysteine and the PI3K/Akt pathway inhibitor LY 294002...
  51. Mertens E, Markey O, Geleijnse J, Givens D, Lovegrove J. Dietary Patterns in Relation to Cardiovascular Disease Incidence and Risk Markers in a Middle-Aged British Male Population: Data from the Caerphilly Prospective Study. Nutrients. 2017;9: pubmed publisher
    ..Dietary pattern 2 (DP2), characterised by higher intake of pulses, fish, poultry, processed/red meat, rice, pasta and vegetables, was not ..
  52. Berding K, Holscher H, Arthur A, Donovan S. Fecal microbiome composition and stability in 4- to 8-year old children is associated with dietary patterns and nutrient intake. J Nutr Biochem. 2018;56:165-174 pubmed publisher
    ..Dietary Pattern 2 (DP2), characterized by intake of grains, dairy and legumes, nuts and seeds, was associated with higher relative ..
  53. Wang G, He Y, Strauch R, Olukolu B, Nielsen D, Li X, et al. Maize Homologs of Hydroxycinnamoyltransferase, a Key Enzyme in Lignin Biosynthesis, Bind the Nucleotide Binding Leucine-Rich Repeat Rp1 Proteins to Modulate the Defense Response. Plant Physiol. 2015;169:2230-43 pubmed publisher
    ..The maize (Zea mays) NLR protein Rp1-D21 derives from an intragenic recombination between two NLRs, Rp1-D and Rp1-dp2, and confers an autoactive HR in the absence of pathogen infection...
  54. Joo H, Kang Y, Kwack M, Sung Y. 15-deoxy prostaglandin J2, the nonenzymatic metabolite of prostaglandin D2, induces apoptosis in keratinocytes of human hair follicles: a possible explanation for prostaglandin D2-mediated inhibition of hair growth. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:809-13 pubmed publisher
    ..inhibit in vitro growth of explanted human hair follicles and inhibit hair growth in mice through the GPR44 (DP2). However, the underlying mechanism is still unclear...
  55. Li F, Wang H, Xin H, Cai J, Fu Q, Jin Y. Development, validation and application of a hydrophilic interaction liquid chromatography-evaporative light scattering detection based method for process control of hydrolysis of xylans obtained from different agricultural wastes. Food Chem. 2016;212:155-61 pubmed publisher
    Purified standards of xylooligosaccharides (XOSs) (DP2-6) were first prepared from a mixture of XOSs using solid phase extraction (SPE), followed by semi-preparative liquid chromatography both under hydrophilic interaction liquid ..
  56. Shi B, Zhao M, Geng T, Qiao L, Zhao Y, Zhao X. Effectiveness and safety of immunosuppressive therapy in neuromyelitis optica spectrum disorder during pregnancy. J Neurol Sci. 2017;377:72-76 pubmed publisher
    ..The annual relapse rate (ARR) before pregnancy (BP); during the first (DP1), second (DP2), and third trimesters (DP3); first trimester postpartum (PP1); and second trimester postpartum (PP2) were ..
  57. Kupczyk M, Kuna P. Targeting the PGD2/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives. Drugs. 2017;77:1281-1294 pubmed publisher
    ..The biological effects of PGD2 are mediated by D-prostanoid (DP1), CRTH2 (DP2), and thromboxane prostanoid (TP) receptors...
  58. Sun L, Guo G, Zhang S, Yang L. Effects of MicroRNA-592-5p on Hippocampal Neuron Injury Following Hypoxic-Ischemic Brain Damage in Neonatal Mice - Involvement of PGD2/DP and PTGDR. Cell Physiol Biochem. 2018;45:458-473 pubmed publisher
    ..reaction (RT-qPCR) and Western blot analyses were performed to detect the expression levels of miR-592-5p, PTGDR, DP2, Bcl-2 and Bax in tissues and cells...
  59. Zhang J, Cao H, Li S, Zhao Y, Wang W, Xu Q, et al. Characterization of a new family 75 chitosanase from Aspergillus sp. W-2. Int J Biol Macromol. 2015;81:362-9 pubmed publisher
    ..Combined with the hydrolysis of COS from DP2 to DP6, CsnW2 was considered to be an endo-acting chitosanase.
  60. Babbar N, Baldassarre S, Maesen M, Prandi B, Dejonghe W, Sforza S, et al. Enzymatic production of pectic oligosaccharides from onion skins. Carbohydr Polym. 2016;146:245-52 pubmed publisher
    ..The experiments reveal that the highest amount of DP2 and DP3 is obtained at a time scale of 75-90min with an EPG-M2 concentration of 26IU/mL...
  61. Tsai C, Chao A, Jung S, Tsai C, Lin C, Chen S, et al. Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells. Oncotarget. 2016;7:50548-50563 pubmed publisher
    ..The N-terminal fragment of STIP1 interacts with the N-terminus of JAK2, whereas the C-terminal DP2 domain of STIP1 mediates the interaction with HSP90 and STAT3...
  62. Jia Yu Y, Qian Z, Fei Fei D, Chuan Jie T, Hui P, Yuan Yuan S, et al. Emergence of novel canine parvovirus type 2 and its pathogenesis in raccoon dogs. Vet Microbiol. 2018;216:7-12 pubmed publisher
    Three parvoviruses were isolated from the raccoon dogs experiencing severe enteritis, named RDPV-DP1, RDPV-DP2 and RDPV-DP3, respectively. The VP2 genes of the 3 isolates showed 99.9% identity at the nucleotide level, and shared 99.1%-99...
  63. Mashchenko E, Amirkhanov K, Ozherelyev D. Morphology of a fossil elephant calf (Archidiskodon, Elephantidae) from the Oldowan Muhkai IIa site. Dokl Biol Sci. 2015;465:274-8 pubmed publisher
    ..A skull fragment and lower jaw with functioning teeth of the DP2/DP3 generation are preserved. The calf is at most 8-10 months of individual age...
  64. Koyani C, Kitz K, Rossmann C, Bernhart E, Huber E, Trummer C, et al. Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death. Biochem Pharmacol. 2016;104:29-41 pubmed publisher
    ..The observed 15d-PGJ2-mediated signalling events are independent of PGD2 receptors (DP1 and DP2) and PPARγ...
  65. Yoon Y, Lee Y, Choi Y, Park Y, Kang J. Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF. Sci Rep. 2016;6:20992 pubmed publisher
    ..LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor (EP4 [AH-23848]), PGD2 receptors (DP1 [BW-A868C] and DP2 [BAY-u3405]), or the hepatocyte growth factor (HGF) receptor c-Met (PHA-665752), reversed EMT inhibition by the ..
  66. Wang G, Balint Kurti P. Maize Homologs of CCoAOMT and HCT, Two Key Enzymes in Lignin Biosynthesis, Form Complexes with the NLR Rp1 Protein to Modulate the Defense Response. Plant Physiol. 2016;171:2166-77 pubmed publisher
    ..Intragenic recombination between two maize (Zea mays) NLRs, Rp1-D and Rp1-dp2, resulted in the formation of a hybrid NLR, Rp1-D21, which confers an autoactive HR in the absence of pathogen ..
  67. Vaikuntapu P, Rambabu S, Madhuprakash J, Podile A. A new chitinase-D from a plant growth promoting Serratia marcescens GPS5 for enzymatic conversion of chitin. Bioresour Technol. 2016;220:200-207 pubmed publisher
    ..Activity studies on CHOS with degree of polymerization (DP) 2-6 as substrate revealed that SmChiD hydrolyzed DP2 with a chitobiase activity and showed TG activity on CHOS with DP3-6, producing longer chain CHOS...
  68. Peana M, Medici S, Pangburn H, Lamkin T, Ostrowska M, Gumienna Kontecka E, et al. Manganese binding to antioxidant peptides involved in extreme radiation resistance in Deinococcus radiodurans. J Inorg Biochem. 2016;164:49-58 pubmed publisher
    A decapeptide, DEHGTAVMLK (DP1), and its random scrambled version, THMVLAKGED (DP2), have been studied for their interactions with manganese...
  69. Granic A, Davies K, Adamson A, Kirkwood T, Hill T, Siervo M, et al. Dietary Patterns High in Red Meat, Potato, Gravy, and Butter Are Associated with Poor Cognitive Functioning but Not with Rate of Cognitive Decline in Very Old Adults. J Nutr. 2016;146:265-74 pubmed publisher
    ..When compared with participants in DP1 (high red meat) and DP3 (high butter), participants in DP2 (low meat) had higher SMMSE scores at baseline (P < 0...
  70. Akbari P, Fink Gremmels J, Willems R, Difilippo E, Schols H, Schoterman M, et al. Characterizing microbiota-independent effects of oligosaccharides on intestinal epithelial cells: insight into the role of structure and size : Structure-activity relationships of non-digestible oligosaccharides. Eur J Nutr. 2017;56:1919-1930 pubmed publisher
    ..Caco-2 monolayers were pretreated (24 h) with or without specific oligosaccharides or DP fractions of VGOS (DP2 to DP6) before being exposed for 12 or 24 h to the fungal toxin deoxynivalenol (DON)...
  71. Abellón Ruiz J, Waldron K, Connolly B. Archaeoglobus Fulgidus DNA Polymerase D: A Zinc-Binding Protein Inhibited by Hypoxanthine and Uracil. J Mol Biol. 2016;428:2805-13 pubmed publisher
    Archaeal family-D DNA polymerases (Pol-D) comprise a small (DP1) proofreading subunit and a large (DP2) polymerase subunit...
  72. Teles C, Mohedano R, Tonon G, Filho P, Costa R. Ecology of duckweed ponds used for nutrient recovery from wastewater. Water Sci Technol. 2017;75:2926-2934 pubmed publisher
    ..A pilot system comprised of two DPs in series (DP1 and DP2), with 10 m2 each, received domestic wastewater through a flow rate of 200 L·day-1...
  73. Moon J, Shin S, Choi H, Joo W, Cho S, Li L, et al. In vitro digestion and fermentation properties of linear sugar-beet arabinan and its oligosaccharides. Carbohydr Polym. 2015;131:50-6 pubmed publisher
    ..The resulting LAOS contained DP2 (28.7%), DP3 (49.9%), DP4 (20.1%), and DP5 (1.16%)...
  74. Werb D, Garfein R, Kerr T, Davidson P, Roux P, Jauffret Roustide M, et al. A socio-structural approach to preventing injection drug use initiation: rationale for the PRIMER study. Harm Reduct J. 2016;13:25 pubmed publisher
    ..Findings have the potential to inform the development and scale up of new and existing interventions to prevent transitions into injecting. Preventing Injecting by Modifying Existing Responses (PRIMER), NIDA DP2-DA040256-01 .
  75. Guan N, Svennersten K, De Verdier P, Wiklund N, Gustafsson L. Prostaglandin D2 effects and DP1 /DP2 receptor distribution in guinea pig urinary bladder out-flow region. J Cell Mol Med. 2017;21:234-243 pubmed publisher
  76. Kumar S, Palaia T, Hall C, Ragolia L. DP1 receptor agonist, BW245C inhibits diet-induced obesity in ApoE-/- mice. Obes Res Clin Pract. 2018;12:229-241 pubmed publisher
    ..In this study, we aimed to investigate the role of PGD2 on obesity through its DP1 and DP2 receptor signaling using intraperitoneal injection of their respective agonists and antagonists...
  77. Ambrosini G, Johns D, Northstone K, Emmett P, Jebb S. Free Sugars and Total Fat Are Important Characteristics of a Dietary Pattern Associated with Adiposity across Childhood and Adolescence. J Nutr. 2016;: pubmed
    ..with greater DED, greater %E from free sugars and total fat, and lower fiber density; higher z scores for DP2 were associated with greater %E from free sugars but lower %E from total fat and DED...
  78. Mahdavi M, Moreau V, Kheirollahi M. Identification of B and T cell epitope based peptide vaccine from IGF-1 receptor in breast cancer. J Mol Graph Model. 2017;75:316-321 pubmed publisher peptide 249 are HLA-DR4, HLA-DR3 and HLA-DR2 and those most often targeted by peptide 86 are HLA-DR4, HLA-DP2 and HLA-DR3...
  79. Litchfield K, Holroyd A, Lloyd A, Broderick P, Nsengimana J, Eeles R, et al. Identification of four new susceptibility loci for testicular germ cell tumour. Nat Commun. 2015;6:8690 pubmed publisher
    ..We identified new risk loci for TGCT at 3q23 (rs11705932, TFDP2, P=1.5 × 10(-9)), 11q14.1 (rs7107174, GAB2, P=9.7 × 10(-11)), 16p13.13 (rs4561483, GSPT1, P=1...
  80. Jandl K, Heinemann A. The therapeutic potential of CRTH2/DP2 beyond allergy and asthma. Prostaglandins Other Lipid Mediat. 2017;133:42-48 pubmed publisher
    ..PGD2 receptor termed chemoattractant receptor homologue expressed on Th2 cells (CRTH2; alternative name DP2) was discovered, diverse investigations started to shed more light on the complex and often controversial actions ..
  81. Trimarchi J, Fairchild B, Verona R, Moberg K, Andon N, Lees J. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc Natl Acad Sci U S A. 1998;95:2850-5 pubmed
    ..Instead, it can act to repress the transcription of E2F responsive genes by countering the activity of the other E2F complexes via a pRB-, p107-, or p130-independent mechanism. ..
  82. Rubin S, Gall A, Zheng N, Pavletich N. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell. 2005;123:1093-106 pubmed
    ..Our findings explain the requirement of RbC for high-affinity E2F binding and growth suppression and establish a mechanism for the regulation of Rb-E2F association by phosphorylation. ..
  83. Litovchick L, Sadasivam S, Florens L, Zhu X, Swanson S, Velmurugan S, et al. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol Cell. 2007;26:539-51 pubmed
    ..This work reveals an evolutionarily conserved multisubunit protein complex that contains p130 and E2F4, but not pRB, and mediates the repression of cell cycle-dependent genes in quiescence. ..
  84. Rozenblatt Rosen O, Deo R, Padi M, Adelmant G, Calderwood M, Rolland T, et al. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012;487:491-5 pubmed publisher
    ..Combining systems-level studies of pathogen-encoded gene products with genomic approaches will facilitate the prioritization of cancer-causing driver genes to advance the understanding of the genetic basis of human cancer...
  85. Stinson S, Amrani Y, Brightling C. D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells. J Allergy Clin Immunol. 2015;135:395-406 pubmed publisher
    The D prostanoid receptor 2 (DP2; also known as chemoattractant receptor-homologous molecule expressed on TH2 cells) is implicated in the pathogenesis of asthma, but its expression within bronchial biopsy specimens is unknown...
  86. Wakai E, Aritake K, Urade Y, Fujimori K. Prostaglandin D2 enhances lipid accumulation through suppression of lipolysis via DP2 (CRTH2) receptors in adipocytes. Biochem Biophys Res Commun. 2017;490:393-399 pubmed publisher
    ..The Gi-coupled DP2 (CRTH2) receptors (DP2R), one of the two-types of PGD2 receptors were dominantly expressed in adipocytes...
  87. Creevy K, Cornell K, Schmiedt C, Park H, Rong H, Radlinsky M, et al. Impact of Expert Commentary and Student Reflection on Veterinary Clinical Decision-Making Skills in an Innovative Electronic-Learning Case-Based Platform. J Vet Med Educ. 2018;45:307-319 pubmed publisher
    ..004; dp2, p =.04; dp4, p <.001; dp5, p <.001)...
  88. Gaubatz S, Wood J, Livingston D. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc Natl Acad Sci U S A. 1998;95:9190-5 pubmed
    ..Taken together, these data suggest that E2F-6 can regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. ..
  89. Huh K, DeMasi J, Ogawa H, Nakatani Y, Howley P, Munger K. Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Proc Natl Acad Sci U S A. 2005;102:11492-7 pubmed
    ..Therefore, p600 is a cellular target of E7 that regulates cellular pathways that contribute to anchorage-independent growth and cellular transformation. ..
  90. Zhang Y, Chellappan S. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogene. 1995;10:2085-93 pubmed
    ..Here we describe the cloning and characterization of a novel human DP gene, DP2, whose product dimerizes efficiently with E2F...
  91. Loiseau L, Pasteau S, Brun G. Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor. Gene Expr. 1997;6:259-73 pubmed
  92. Zheng N, Fraenkel E, Pabo C, Pavletich N. Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev. 1999;13:666-74 pubmed
    ..The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-..