Genomes and Genes
Gene Symbol: TEX14
Description: testis expressed 14, intercellular bridge forming factor
Alias: CT113, SPGF23, inactive serine/threonine-protein kinase TEX14, cancer/testis antigen 113, protein kinase-like protein SgK307, sugen kinase 307, testis-expressed protein 14, testis-expressed sequence 14 protein
- Fatemifar G, Hoggart C, Paternoster L, Kemp J, Prokopenko I, Horikoshi M, et al. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. Hum Mol Genet. 2013;22:3807-17 pubmed publisher..Our results suggest that the genome-wide association approach is a powerful strategy for detecting variants involved in tooth eruption, and potentially craniofacial growth and more generally organ development. ..
- Chung C, Kanetsky P, Wang Z, Hildebrandt M, Koster R, Skotheim R, et al. Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet. 2013;45:680-5 pubmed publisher..33; P = 4.32 × 10(-13) and rs7221274: OR = 1.20, 95% CI = 1.12-1.28; P = 4.04 × 10(-9)), a locus that includes TEX14, RAD51C and PPM1E...
- Benyamin B, Esko T, Ried J, Radhakrishnan A, Vermeulen S, Traglia M, et al. Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun. 2014;5:4926 pubmed publisher..known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis...
- Karlin K, Mondal G, Hartman J, Tyagi S, Kurley S, Bland C, et al. The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Rep. 2014;9:1318-32 pubmed publisher..In this study, we used a forward genetic screen to discover an oncogenic network driving human TNBC. SCYL1, TEX14, and PLK1 ("STP axis") cooperatively trigger degradation of the REST tumor suppressor protein, a frequent event in ..
- Kim H, Yoon J, Matsuura A, Na J, Lee W, Kim H, et al. Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells. Proc Natl Acad Sci U S A. 2015;112:12372-7 pubmed publisher..The TEX14 (testis-expressed gene 14) protein is recruited to the midbody and plays a key role in the inactivation of germ ..