TEX14

Summary

Gene Symbol: TEX14
Description: testis expressed 14, intercellular bridge forming factor
Alias: CT113, SPGF23, inactive serine/threonine-protein kinase TEX14, cancer/testis antigen 113, protein kinase-like protein SgK307, sugen kinase 307, testis-expressed protein 14, testis-expressed sequence 14 protein
Species: human
Products:     TEX14

Top Publications

  1. Wu M, Rajkovic A, Burns K, Yan W, Lin Y, Matzuk M. Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. Gene Expr Patterns. 2003;3:231-6 pubmed
    To discover germ cell-specific genes, we used in silico subtraction and identified testis expressed gene 14 (Tex14)...
  2. Mondal G, Ohashi A, Yang L, Rowley M, Couch F. Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. Mol Cell. 2012;45:680-95 pubmed publisher
    ..Here we show that testis-expressed protein 14 (Tex14), which has been implicated in midbody function, is recruited to KTs by Plk1 in a Cdk1-dependent manner during ..
  3. Gershoni M, Hauser R, Yogev L, Lehavi O, Azem F, Yavetz H, et al. A familial study of azoospermic men identifies three novel causative mutations in three new human azoospermia genes. Genet Med. 2017;19:998-1006 pubmed publisher
    ..We identified three novel likely causative mutations of azoospermia in three genes: MEIOB, TEX14, and DNAH6...
  4. Fakhro K, Elbardisi H, Arafa M, Robay A, Rodriguez Flores J, Al Shakaki A, et al. Point-of-care whole-exome sequencing of idiopathic male infertility. Genet Med. 2018;20:1365-1373 pubmed publisher
    ..In five of eight families, we identified rare deleterious recessive variants in CCDC155, NANOS2, SPO11, TEX14, and WNK3 segregating with disease...
  5. Do D, Bissonnette N, Lacasse P, Miglior F, Sargolzaei M, Zhao X, et al. Genome-wide association analysis and pathways enrichment for lactation persistency in Canadian Holstein cattle. J Dairy Sci. 2017;100:1955-1970 pubmed publisher
    ..Based on physical positions, MAN1C1, MAP3K5, HCN1, TSPAN9, MRPS30, TEX14, and CCL28 are potential candidate genes for LP because the significant SNP were located in their intronic regions...
  6. Marcotte E, Pankratz N, Amatruda J, Frazier A, Krailo M, Davies S, et al. Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group. Genes Chromosomes Cancer. 2017;56:548-558 pubmed publisher
    ..66 [1.21, 2.28]) and a paternal parent-of-origin effect was observed for rs7221274 (P?=?0.00007), near TEX14, RAD51C, and PPM1E. We observed associations between SNPs in SPRY4, BAK1, and GAB2 and GCTs...
  7. Manning G, Whyte D, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. 2002;298:1912-34 pubmed
    ..We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons. ..
  8. Iwamori T, Iwamori N, Ma L, Edson M, Greenbaum M, Matzuk M. TEX14 interacts with CEP55 to block cell abscission. Mol Cell Biol. 2010;30:2280-92 pubmed publisher
    ..cytokinesis is arrested prior to abscission in differentiating male germ cells that are interconnected by TEX14-positive intercellular bridges...
  9. Ruark E, Seal S, McDonald H, Zhang F, Elliot A, Lau K, et al. Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. Nat Genet. 2013;45:686-9 pubmed publisher
    ..3, is required for the regulation of germ cell development. Furthermore, PITX1, at 5q31.1, regulates TERT expression and is the third TGCT-associated locus implicated in telomerase regulation...

More Information

Publications14

  1. Fatemifar G, Hoggart C, Paternoster L, Kemp J, Prokopenko I, Horikoshi M, et al. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. Hum Mol Genet. 2013;22:3807-17 pubmed publisher
    ..Our results suggest that the genome-wide association approach is a powerful strategy for detecting variants involved in tooth eruption, and potentially craniofacial growth and more generally organ development. ..
  2. Chung C, Kanetsky P, Wang Z, Hildebrandt M, Koster R, Skotheim R, et al. Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet. 2013;45:680-5 pubmed publisher
    ..33; P = 4.32 × 10(-13) and rs7221274: OR = 1.20, 95% CI = 1.12-1.28; P = 4.04 × 10(-9)), a locus that includes TEX14, RAD51C and PPM1E...
  3. Benyamin B, Esko T, Ried J, Radhakrishnan A, Vermeulen S, Traglia M, et al. Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun. 2014;5:4926 pubmed publisher
    ..known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis...
  4. Karlin K, Mondal G, Hartman J, Tyagi S, Kurley S, Bland C, et al. The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Rep. 2014;9:1318-32 pubmed publisher
    ..In this study, we used a forward genetic screen to discover an oncogenic network driving human TNBC. SCYL1, TEX14, and PLK1 ("STP axis") cooperatively trigger degradation of the REST tumor suppressor protein, a frequent event in ..
  5. Kim H, Yoon J, Matsuura A, Na J, Lee W, Kim H, et al. Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells. Proc Natl Acad Sci U S A. 2015;112:12372-7 pubmed publisher
    ..The TEX14 (testis-expressed gene 14) protein is recruited to the midbody and plays a key role in the inactivation of germ ..