TET1

Summary

Gene Symbol: TET1
Description: tet oncogene 1
Alias: CXXC6, FLJ10839, FLJ41442, KIAA1676, LCX, bA119F7.1, CXXC finger 6, OTTHUMP00000019708, OTTHUMP00000060749, leukemia-associated protein with a CXXC domain, ten-eleven translocation-1
Species: human
Products:     TET1 antibody    TET1 cDNA    TET1 siRNA/shRNA    TET1 others

Webpages

  1. guillermo garcia-manero - leukemia - faculty - md anderson cancer center
    faculty.mdanderson.org/Guillermo_Garcia-Manero/Default.asp?S ...
  2. no title
    www.unu.edu/gs/files/2008/hk/HK08_Okuda_abstractJP.pdf
  3. no title
    www.drexel.edu/international/assets/pdf/ita/grad/Chen.pdf
  4. no title
    www.infosys.tuwien.ac.at/Staff/sd/papers/TestingOfServiceOri ...

Research Grants

  1. Microbial Recognition by Innate Immune Receptors
    Roy A Mariuzza; Fiscal Year: 2008
  2. Microbial Recognition by Innate Immune Receptors
    Roy A Mariuzza; Fiscal Year: 2007

Publications

  1. Comparison of the thrombolytic efficacy of defibrase and urokinase on canine coronary artery thrombosis and the mechanism of urokinase-induced hemorrhage
    D X Huang
    Cardiology Department, Chinese P L A General Hospital, Beijing
    Acta Cardiol 42:249-61
  2. Prevention of thrombosis and rethrombosis and enhancement of the thrombolytic actions of recombinant tissue-type plasminogen activator in the canine heart by DMP728, a glycoprotein IIb/IIIa antagonist
    B R Lucchessi
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109 0632
    Br J Pharmacol 113:1333-43
  3. Six months clinical, angiographic, and IVUS follow-up after PTFE graft stent implantation in native coronary arteries
    G Lukito
    Department of Cardiology, Heart Center Hasselt, Virga Jesse Hospital, Belgium
    Acta Cardiol 55:255-60
  4. LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
    Ryoichi Ono
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, 113 8655, Japan
    Cancer Res 62:4075-80
  5. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)
    R B Lorsbach
    Leukemia 17:637-41
  6. Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 147:727-31
  7. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    Mamta Tahiliani
    Department of Pathology, Harvard Medical School and Immune Disease Institute, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 324:930-5
  8. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    Omar Abdel Wahab
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Blood 114:144-7

Detail Information

Webpages6

  1. guillermo garcia-manero - leukemia - faculty - md anderson cancer center
    faculty.mdanderson.org/Guillermo_Garcia-Manero/Default.asp?S ...
  2. no title
    www.unu.edu/gs/files/2008/hk/HK08_Okuda_abstractJP.pdf
  3. no title
    www.drexel.edu/international/assets/pdf/ita/grad/Chen.pdf
  4. no title
    www.infosys.tuwien.ac.at/Staff/sd/papers/TestingOfServiceOri ...

Research Grants2

  1. Microbial Recognition by Innate Immune Receptors
    Roy A Mariuzza; Fiscal Year: 2008
    ..PGRP-LC, a cell surface receptor required for Imd pathway activation, PGRP-LC exists as three splice isoforms (LCa, LCx, LCy) that form homo- or heterodimers with distinct PGN specificities...
  2. Microbial Recognition by Innate Immune Receptors
    Roy A Mariuzza; Fiscal Year: 2007
    ..PGRP-LC, a cell surface receptor required for Imd pathway activation, PGRP-LC exists as three splice isoforms (LCa, LCx, LCy) that form homo- or heterodimers with distinct PGN specificities...

Publications8

  1. Comparison of the thrombolytic efficacy of defibrase and urokinase on canine coronary artery thrombosis and the mechanism of urokinase-induced hemorrhage
    D X Huang
    Cardiology Department, Chinese P L A General Hospital, Beijing
    Acta Cardiol 42:249-61
    ..DF) and urokinase (UK) was evaluated and compared in a canine model in which left circumflex coronary artery (LCX) thrombus formation was initiated by electrical stimulation (150 UA, DC) of the arterial intimal surface via an ..
  2. Prevention of thrombosis and rethrombosis and enhancement of the thrombolytic actions of recombinant tissue-type plasminogen activator in the canine heart by DMP728, a glycoprotein IIb/IIIa antagonist
    B R Lucchessi
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109 0632
    Br J Pharmacol 113:1333-43
    ..and a 150 microA anodal current was applied to the intimal surface of the left circumflex coronary artery (LCX). Dogs were monitored for 6 h and again on each of 5 subsequent days. 3...
  3. Six months clinical, angiographic, and IVUS follow-up after PTFE graft stent implantation in native coronary arteries
    G Lukito
    Department of Cardiology, Heart Center Hasselt, Virga Jesse Hospital, Belgium
    Acta Cardiol 55:255-60
    ..A stress test was also done at 6 months. RESULTS : The coronary arteries treated were: RCA in 7 patients, LCX in 2 patients, LAD in 1 patient. Mean balloon size was 3.7 mm diameter, and mean inflation pressure was 18 atm (min...
  4. LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
    Ryoichi Ono
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, 113 8655, Japan
    Cancer Res 62:4075-80
    ..We showed that the MLL gene on 11q23 was fused to the LCX (leukemia-associated protein with a CXXC domain) gene on 10q22 in a de novoadult AML-M2 with trilineage dysplasia ..
  5. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)
    R B Lorsbach
    Leukemia 17:637-41
  6. Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 147:727-31
    ..24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls...
  7. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    Mamta Tahiliani
    Department of Pathology, Harvard Medical School and Immune Disease Institute, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 324:930-5
    ..We show here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme ..
  8. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    Omar Abdel Wahab
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Blood 114:144-7
    ..Based on the recent identification of TET2 mutations, we evaluated the mutational status of TET1, TET2, and TET3 in myeloproliferative neoplasms (MPNs), chronic myelomonocytic leukemia (CMML), and acute myeloid ..