Gene Symbol: TESK2
Description: testis associated actin remodelling kinase 2
Alias: dual specificity testis-specific protein kinase 2, testicular protein kinase 2, testis-specific kinase 2
Species: human
Products:     TESK2

Top Publications

  1. Singh M, Venugopal C, Tokar T, McFarlane N, Subapanditha M, Qazi M, et al. Therapeutic Targeting of the Premetastatic Stage in Human Lung-to-Brain Metastasis. Cancer Res. 2018;78:5124-5134 pubmed publisher
    ..prevented BM formation, potentially by targeting premetastasis-associated genes KIF16B, SEPW1, and TESK2 Low expression of these genes was associated with poor survival of patients with lung adenocarcinoma...
  2. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, et al. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature. 1998;393:809-12 pubmed
    ..Furthermore, insulin and an active form of Rac increase the activity of LIMK-1. Taken together, our results indicate that LIMK-1 participates in Rac-mediated actin cytoskeletal reorganization, probably by phosphorylating cofilin. ..
  3. Røsok O, Pedeutour F, Ree A, Aasheim H. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. Genomics. 1999;61:44-54 pubmed
    In this study we present the cDNA sequence of a novel putative protein kinase, denoted TESK2. The open reading frame of TESK2 encodes a putative 555-amino-acid protein, including a protein kinase consensus sequence in the N-terminal half...
  4. Toshima J, Toshima J, Takeuchi K, Mori R, Mizuno K. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. J Biol Chem. 2001;276:31449-58 pubmed
    ..We now report identification and characterization of another member of a TESK family, testicular protein kinase 2 (TESK2), with 48% amino acid identity with TESK1...
  5. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser M, et al. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proc Natl Acad Sci U S A. 2015;112:15372-7 pubmed publisher
  6. van den Berg M, Warren H, Cabrera C, Verweij N, Mifsud B, Haessler J, et al. Discovery of novel heart rate-associated loci using the Exome Chip. Hum Mol Genet. 2017;26:2346-2363 pubmed publisher
    ..Lead variants in four of the novel loci are non-synonymous variants in the genes C10orf71, DALDR3, TESK2 and SEC31B...
  7. Sumi T, Matsumoto K, Shibuya A, Nakamura T. Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. J Biol Chem. 2001;276:23092-6 pubmed
    ..These results indicate that MRCKalpha phosphorylates and activates LIM kinases downstream of Cdc42, which in turn regulates the actin cytoskeletal reorganization through the phosphorylation and inactivation of ADF/cofilin. ..
  8. Toshima J, Toshima J, Watanabe T, Mizuno K. Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1. J Biol Chem. 2001;276:43471-81 pubmed
    ..We propose that 14-3-3beta plays important roles in regulating the kinase activity of TESK1 and localizing TESK1 to cell adhesion sites following integrin stimulation. ..
  9. Pan L, Xu R, Wen J, Guo R. Assessing PAHs pollution in Shandong coastal area (China) by combination of chemical analysis and responses of reproductive toxicity in crab Portunus trituberculatus. Environ Sci Pollut Res Int. 2017;24:14291-14303 pubmed publisher
    ..protein carbonyl content, and lipid peroxidation levels in two genders, 17?-estradiol in female, testosterone and TESK2 gene expression in male crabs, were closely correlated with the concentrations of PAHs (2 + 3 rings, 4 rings, ..