TERT

Summary

Gene Symbol: TERT
Description: telomerase reverse transcriptase
Alias: CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, telomerase catalytic subunit, telomerase-associated protein 2
Species: human
Products:     TERT

Top Publications

  1. Myneni A, Chang S, Niu R, Liu L, Ochs Balcom H, Li Y, et al. Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population. Lung Cancer. 2013;80:131-7 pubmed publisher
    Genetic variants of telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like (CLPTM1L) genes in chromosome 5p15.33 region were previously identified to influence the susceptibility to lung cancer...
  2. Calado R, Brudno J, Mehta P, Kovacs J, Wu C, Zago M, et al. Constitutional telomerase mutations are genetic risk factors for cirrhosis. Hepatology. 2011;53:1600-7 pubmed publisher
    ..University of Arizona, between May 2008 and July 2009, and 528 healthy subjects were screened for variation in the TERT and TERC genes by direct sequencing; an additional 1,472 controls were examined for the most common genetic ..
  3. Huang F, Hodis E, Xu M, Kryukov G, Chin L, Garraway L. Highly recurrent TERT promoter mutations in human melanoma. Science. 2013;339:957-9 pubmed publisher
    ..Here, we describe two independent mutations within the core promoter of telomerase reverse transcriptase (TERT), the gene coding for the catalytic subunit of telomerase, which collectively occur in 50 of 70 ..
  4. Wang H, Zhang X, Jin B. TERT genetic polymorphism rs2736100 was associated with lung cancer: a meta-analysis based on 14,492 subjects. Genet Test Mol Biomarkers. 2013;17:937-41 pubmed publisher
    Previous studies focused on the association of the telomerase reverse transcriptase (TERT) gene polymorphism rs2736100 with lung cancer did not reach the same conclusion...
  5. Haiman C, Chen G, Vachon C, Canzian F, Dunning A, Millikan R, et al. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet. 2011;43:1210-4 pubmed publisher
    ..We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10))...
  6. Shen J, Gammon M, Wu H, Terry M, Wang Q, Bradshaw P, et al. Multiple genetic variants in telomere pathway genes and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2010;19:219-28 pubmed publisher
    ..05. The top three statistically significant SNPs under a dominant model were TERT-07 (rs2736109), TERT-54 (rs3816659), and POT1-03 (rs33964002). The odds ratios (OR) were 1...
  7. Petersen G, Amundadottir L, Fuchs C, Kraft P, Stolzenberg Solomon R, Jacobs K, et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010;42:224-8 pubmed publisher
    ..71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers...
  8. Hosgood H, Cawthon R, He X, Chanock S, Lan Q. Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. Lung Cancer. 2009;66:157-61 pubmed publisher
    ..length separately and in conjunction with single nucleotide polymorphisms in the telomere maintenance genes POT1, TERT, and TERF2, which we have previously reported were associated with risk of lung cancer in this study...
  9. Bojesen S, Pooley K, Johnatty S, Beesley J, Michailidou K, Tyrer J, et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 2013;45:371-84, 384e1-2 pubmed publisher
    b>TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers...

More Information

Publications318 found, 100 shown here

  1. Turnbull C, Rapley E, Seal S, Pernet D, Renwick A, Hughes D, et al. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat Genet. 2010;42:604-7 pubmed publisher
    ..We identified two independent signals within the TERT-CLPTM1L locus on chromosome 5, which has previously been associated with multiple other cancers (rs4635969, OR=1...
  2. Fingerlin T, Murphy E, Zhang W, Peljto A, Brown K, Steele M, et al. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet. 2013;45:613-20 pubmed publisher
    ..We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2...
  3. Remke M, Ramaswamy V, Peacock J, Shih D, Koelsche C, Northcott P, et al. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathol. 2013;126:917-29 pubmed publisher
    b>Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma...
  4. Maida Y, Yasukawa M, Okamoto N, Ohka S, Kinoshita K, Totoki Y, et al. Involvement of telomerase reverse transcriptase in heterochromatin maintenance. Mol Cell Biol. 2014;34:1576-93 pubmed publisher
    ..In association with the telomerase RNA component (TERC), the telomerase reverse transcriptase (TERT) forms telomerase and counteracts telomere attrition, and without TERC, TERT has been ..
  5. Heidenreich B, Nagore E, Rachakonda P, Garcia Casado Z, Requena C, Traves V, et al. Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma. Nat Commun. 2014;5:3401 pubmed publisher
    ..somatic mutations in metastasized tumours from unrelated patients in the core promoter region of the telomerase reverse transcriptase (TERT) gene...
  6. Li Y, Tergaonkar V. Noncanonical functions of telomerase: implications in telomerase-targeted cancer therapies. Cancer Res. 2014;74:1639-44 pubmed publisher
    ..This review summarizes recent insights to the noncanonical functions of telomerase reverse transcriptase (TERT) catalytic subunit, in particular in cancer progression, and highlights two major signaling ..
  7. Heidenreich B, Rachakonda P, Hemminki K, Kumar R. TERT promoter mutations in cancer development. Curr Opin Genet Dev. 2014;24:30-7 pubmed publisher
    Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of telomerase that maintains genomic integrity...
  8. Pópulo H, Boaventura P, Vinagre J, Batista R, Mendes A, Caldas R, et al. TERT promoter mutations in skin cancer: the effects of sun exposure and X-irradiation. J Invest Dermatol. 2014;134:2251-2257 pubmed publisher
    The reactivation or reexpression of telomerase (TERT) is a widespread feature of neoplasms. TERT promoter mutations were recently reported that were hypothesized to result from UV radiation...
  9. Killela P, Pirozzi C, Healy P, Reitman Z, Lipp E, Rasheed B, et al. Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas. Oncotarget. 2014;5:1515-25 pubmed
    Frequent mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and the promoter of telomerase reverse transcriptase (TERT) represent two significant discoveries in glioma genomics...
  10. Wang N, Liu T, Sofiadis A, Juhlin C, Zedenius J, Höög A, et al. TERT promoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA. Cancer. 2014;120:2965-79 pubmed publisher
    The telomerase reverse transcriptase (TERT) promoter mutations C228T and C250T have been found in many malignancies, including in thyroid carcinomas. However, it is unclear how early these mutations occur in thyroid tumorigenesis...
  11. Xing M, Liu R, Liu X, Murugan A, Zhu G, Zeiger M, et al. BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. J Clin Oncol. 2014;32:2718-26 pubmed publisher
    To investigate the prognostic value of the BRAF V600E mutation and the recently identified TERT promoter mutation chr5:1,295,228C>T (C228T), individually and in their coexistence, in papillary thyroid cancer (PTC)...
  12. Xie H, Liu T, Wang N, Björnhagen V, Höög A, Larsson C, et al. TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinoma. Oncotarget. 2014;5:10048-57 pubmed
    Telomerase activation through the induction of its catalytic component TERT is essential in carcinogenesis...
  13. Wang K, Liu T, Liu L, Liu J, Liu C, Wang C, et al. TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas. Oncotarget. 2014;5:1829-36 pubmed
    b>TERT promoter mutations are identified in many malignancies including bladder cancer (BC) and upper tract urothelial carcinoma (UTUC). In contrast, no mutations were found in renal cell carcinoma (RCC) as reported in a recent study...
  14. Xi L, Cech T. Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT. Nucleic Acids Res. 2014;42:8565-77 pubmed publisher
    ..levels of the human telomerase RNP and its two key components, human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT)...
  15. Savage S, Chanock S, Lissowska J, Brinton L, Richesson D, Peplonska B, et al. Genetic variation in five genes important in telomere biology and risk for breast cancer. Br J Cancer. 2007;97:832-6 pubmed
    ..cancer cases and 2296 controls from Poland, 24 SNPs representing common variation in POT1, TEP1, TERF1, TERF2 and TERT were genotyped...
  16. Fu D, Collins K. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell. 2007;28:773-85 pubmed
  17. Cronkhite J, Xing C, Raghu G, Chin K, Torres F, Rosenblatt R, et al. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med. 2008;178:729-37 pubmed publisher
    Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres...
  18. Schoemaker M, Robertson L, Wigertz A, Jones M, Hosking F, Feychting M, et al. Interaction between 5 genetic variants and allergy in glioma risk. Am J Epidemiol. 2010;171:1165-73 pubmed publisher
    ..Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13...
  19. Ding D, Xi P, Zhou J, Wang M, Cong Y. Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-?B-dependent transcription. FASEB J. 2013;27:4375-83 pubmed publisher
    ..However, accumulating evidence indicates that telomerase reverse transcriptase may have fundamental biological functions independent of its enzymatic activity in telomere ..
  20. Wang L, Li P, Geng M, Cao Y, Yin Y. Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer. Diagn Pathol. 2013;8:33 pubmed publisher
    ..Here we evaluated the chemosensitivity of GC to anticancer drugs and the telomerase reverse transcriptase (hTERT) mRNA expression, and investigated the relationship of them...
  21. Meyerson M, Counter C, Eaton E, Ellisen L, Steiner P, Caddle S, et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell. 1997;90:785-95 pubmed
    ..We report the cloning of a human gene, hEST2, that shares significant sequence similarity with the telomerase catalytic subunit genes of lower eukaryotes...
  22. Prescott J, McGrath M, Lee I, Buring J, De Vivo I. Telomere length and genetic analyses in population-based studies of endometrial cancer risk. Cancer. 2010;116:4275-82 pubmed publisher
    ..relative telomere length in peripheral blood leukocytes, genetic variants at telomere maintenance gene loci (TERT, TNKS2, POT1, TERF1, TERF2), and endometrial cancer risk in case-control studies nested within the Nurses' Health ..
  23. Horikawa I, Cable P, Afshari C, Barrett J. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res. 1999;59:826-30 pubmed
    ..Regulation of expression of the catalytic subunit, human telomerase reverse transcriptase (hTERT), is suggested as the major determinant of the enzymatic activity...
  24. Nomoto K, Maekawa M, Sugano K, Ushiama M, Fukayama N, Fujita S, et al. Methylation status and expression of human telomerase reverse transcriptase mRNA in relation to hypermethylation of the p16 gene in colorectal cancers as analyzed by bisulfite PCR-SSCP. Jpn J Clin Oncol. 2002;32:3-8 pubmed
    The expression level of human telomerase reverse transcriptase (hTERT) is correlated with telomerase activity and is expressed at high levels in malignant tumors...
  25. Zhao Y, Abreu E, Kim J, Stadler G, Eskiocak U, Terns M, et al. Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Mol Cell. 2011;42:297-307 pubmed publisher
    ..Overexpressed telomerase is also less processive than the endogenously expressed telomerase. These findings reveal two major distinct extension modes adopted by telomerase in vivo. ..
  26. Sinha Datta U, Horikawa I, Michishita E, Datta A, Sigler Nicot J, Brown M, et al. Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. Blood. 2004;104:2523-31 pubmed
    ..Although Tax impaired induction of human telomerase reverse transcriptase (hTERT) mRNA in response to mitogenic stimulation, transduction of Tax into primary lymphocytes was ..
  27. Hoffmeyer K, Raggioli A, Rudloff S, Anton R, Hierholzer A, Del Valle I, et al. Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. Science. 2012;336:1549-54 pubmed publisher
    ..Here, we report a molecular link between Wnt/?-catenin signaling and the expression of the telomerase subunit Tert. ?-Catenin-deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cell expressing an ..
  28. Yin J, Li Y, Yin M, Sun J, Liu L, Qin Q, et al. TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications. PLoS ONE. 2012;7:e50650 pubmed publisher
    Some common genetic variants of TERT-CLPTM1L gene, which encode key protein subunits of telomerase, have been suggested to play a crucial role in tumorigenesis...
  29. Griewank K, Murali R, Schilling B, Scholz S, Sucker A, Song M, et al. TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours. Br J Cancer. 2013;109:497-501 pubmed publisher
    Recently, activating mutations in the TERT promoter were identified in cutaneous melanoma. We tested a cohort of ocular melanoma samples for similar mutations.
  30. Vinagre J, Almeida A, Pópulo H, Batista R, Lyra J, Pinto V, et al. Frequency of TERT promoter mutations in human cancers. Nat Commun. 2013;4:2185 pubmed publisher
    ..Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and ..
  31. Mittal A, Pate M, Wylie R, Tollefsbol T, Katiyar S. EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Int J Oncol. 2004;24:703-10 pubmed
  32. Veldman T, Liu X, Yuan H, Schlegel R. Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc Natl Acad Sci U S A. 2003;100:8211-6 pubmed
    ..This increase in enzyme activity reflects E6-enhanced transcription of the human telomerase reverse transcriptase (hTERT) catalytic subunit, but the molecular basis for this transactivation is unknown...
  33. Nguyen M, Kraft R, Aubert M, Goodwin E, DiMaio D, Blaho J. p53 and hTERT determine sensitivity to viral apoptosis. J Virol. 2007;81:12985-95 pubmed
    ..Given the universality of the apoptotic antiviral response, p53 and telomerase regulation will likely be important for counteracting host defenses in many other viral infections. ..
  34. Haendeler J, Dröse S, Büchner N, Jakob S, Altschmied J, Goy C, et al. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol. 2009;29:929-35 pubmed publisher
    The enzyme telomerase and its catalytic subunit the telomerase reverse transcriptase (TERT) are important for maintenance of telomere length in the nucleus. Recent studies provided evidence for a mitochondrial localization of TERT...
  35. Chen G, Da L, Xu Y, Xu M, Song L, Li T, et al. C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition. Biochem Biophys Res Commun. 2010;398:683-9 pubmed publisher
    ..inhibitor composed of 328 amino acids, binds to the telomere associated protein Pin2/TRF1 and to the telomerase catalytic subunit hTERT. However, the mechanism by which LPTS/PinX1 regulates telomerase activity remains unclear...
  36. Hou M, Wang X, Popov N, Zhang A, Zhao X, Zhou R, et al. The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells. Exp Cell Res. 2002;274:25-34 pubmed
    ..for cellular immortalization and transformation, requires the induction of its catalytic component, telomerase reverse transcriptase (hTERT)...
  37. Andersson U, Osterman P, Sjöström S, Johansen C, Henriksson R, Brannstrom T, et al. MNS16A minisatellite genotypes in relation to risk of glioma and meningioma and to glioblastoma outcome. Int J Cancer. 2009;125:968-72 pubmed publisher
    The human telomerase reverse transcriptase (hTERT) gene is upregulated in a majority of malignant tumours. A variable tandem repeat, MNS16A, has been reported to be of functional significance for hTERT expression...
  38. Kirwan M, Vulliamy T, Marrone A, Walne A, Beswick R, Hillmen P, et al. Defining the pathogenic role of telomerase mutations in myelodysplastic syndrome and acute myeloid leukemia. Hum Mutat. 2009;30:1567-73 pubmed publisher
    ..Recently, an increased incidence of telomerase reverse transcriptase mutations has been reported in a series of de novo AML...
  39. Wenz C, Enenkel B, Amacker M, Kelleher C, Damm K, Lingner J. Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 2001;20:3526-34 pubmed
    ..Reverse transcription of the RNA template is catalyzed by the telomerase reverse transcriptase (TERT) protein subunit...
  40. Lue N, Bosoy D, Moriarty T, Autexier C, Altman B, Leng S. Telomerase can act as a template- and RNA-independent terminal transferase. Proc Natl Acad Sci U S A. 2005;102:9778-83 pubmed
    ..The terminal transferase activity of telomerase may account for some of the hitherto unexplained effects of telomerase overexpression on cell physiology. ..
  41. Harada H, Nakagawa H, Oyama K, Takaoka M, Andl C, Jacobmeier B, et al. Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation. Mol Cancer Res. 2003;1:729-38 pubmed
    ..These comprehensive results indicate that the expression of telomerase induces immortalization of normal human esophageal keratinocytes without inactivation of p16INK4a/pRb pathway or abrogation of the p53 pathway. ..
  42. Fujiki T, Miura T, Maura M, Shiraishi H, Nishimura S, Imada Y, et al. TAK1 represses transcription of the human telomerase reverse transcriptase gene. Oncogene. 2007;26:5258-66 pubmed
    ..activity is tightly regulated by the expression of its catalytic subunit, namely, the human telomerase reverse transcriptase (hTERT)...
  43. Takano T, Ito Y, Matsuzuka F, Miya A, Kobayashi K, Yoshida H, et al. Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines. Oncol Rep. 2007;18:715-20 pubmed
    ..chain reaction, we measured the mRNA expression levels of three representative genes, telomerase reverse transcriptase (hTERT), thyroglobulin and thyroid transcription factor 1 (TTF-1) in twelve frozen tissue samples of ..
  44. Akutagawa O, Nishi H, Kyo S, Terauchi F, Yamazawa K, Higuma C, et al. Early growth response-1 mediates downregulation of telomerase in cervical cancer. Cancer Sci. 2008;99:1401-6 pubmed publisher
    ..of a site that was thought to be an Egr-1 consensus binding site at -273 to -281 in the human telomerase reverse transcriptase (hTERT) promoter region, the present study was conducted to evaluate the role of Egr-1 in the ..
  45. Indran I, Hande M, Pervaiz S. hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Res. 2011;71:266-76 pubmed publisher
    The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the telomerase holoenzyme. Evidence is accumulating to link hTERT to activities other than telomere maintenance and immortalization...
  46. Papanikolaou V, Athanassiou E, Dubos S, Dimou I, Papathanasiou I, Kitsiou Tzeli S, et al. hTERT regulation by NF-?B and c-myc in irradiated HER2-positive breast cancer cells. Int J Radiat Biol. 2011;87:609-21 pubmed publisher
    ..In the present study, we investigated the expression of human telomerase reverse transcriptase (hTERT) and TA and their regulation, as well as apoptotic rates and correlation with the presence of ..
  47. Zee R, Ridker P, Chasman D. Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study. Clin Chim Acta. 2011;412:199-202 pubmed publisher
    ..The associations between 154 tag-single nucleotide polymorphisms (tSNPs) of 11 telomere-associated candidate genes (TERT, POT1, TNKS, TERF1, TNKS2, UCP2, TEP1, ACD, TERF2, TERF2IP, and TERC) were investigated in 23,294 Caucasian ..
  48. Lan J, Xiong Y, Lin Y, Wang B, Gong L, Xu H, et al. Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation. World J Gastroenterol. 2003;9:54-8 pubmed
  49. Liu X, Dakic A, Chen R, Disbrow G, Zhang Y, Dai Y, et al. Cell-restricted immortalization by human papillomavirus correlates with telomerase activation and engagement of the hTERT promoter by Myc. J Virol. 2008;82:11568-76 pubmed publisher
  50. Hartmann D, Srivastava U, Thaler M, Kleinhans K, N Kontchou G, Scheffold A, et al. Telomerase gene mutations are associated with cirrhosis formation. Hepatology. 2011;53:1608-17 pubmed publisher
    ..The telomerase RNA component (TERC) and the telomerase reverse transcriptase (TERT) were sequenced in 1,121 individuals (521 patients with cirrhosis induced by chronic liver ..
  51. Shen Y, Wang Y, Chen S, Xiao B, Su J, Tao Z. [The effect of shRNA targeting hTERT on telomerase and the expression of PCNA and Caspase-3 in nasopharyngeal carcinoma cells]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008;22:411-5 pubmed
    ..Here, we investigate the effect of short hairpin RNA (shRNA) specific for human telomerase reverse transcriptase (hTERT) mRNA on the expression of proliferating cell nuclear antigen (PCNA) and Caspase-3 in ..
  52. Zhang A, Zheng C, Hou M, Lindvall C, Li K, Erlandsson F, et al. Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome. Am J Hum Genet. 2003;72:940-8 pubmed
    Cri du chat syndrome (CdCS) results from loss of the distal portion of chromosome 5p, where the telomerase reverse transcriptase (hTERT) gene is localized (5p15.33)...
  53. Vulliamy T, Walne A, Baskaradas A, Mason P, Marrone A, Dokal I. Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure. Blood Cells Mol Dis. 2005;34:257-63 pubmed
    ..the RNA molecule (TERC) that provides the template for telomere repeat elongation and a reverse transcriptase (TERT) that is responsible for the addition of telomere repeats at the ends of each chromosome...
  54. DU H, Pumbo E, Ivanovich J, An P, Maziarz R, Reiss U, et al. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. Blood. 2009;113:309-16 pubmed publisher
    ..inherited form of bone marrow failure (BMF) caused by mutations in telomere maintaining genes including TERC and TERT. Here we studied the prevalence of TERC and TERT gene mutations and of telomere shortening in an unselected ..
  55. Sirera R, Bremnes R, Cabrera A, Jantus Lewintre E, Sanmartín E, Blasco A, et al. Circulating DNA is a useful prognostic factor in patients with advanced non-small cell lung cancer. J Thorac Oncol. 2011;6:286-90 pubmed publisher
    ..Our aim was to prospectively study the association between the catalytic subunit of telomerase (human telomerase reverse transcriptase [hTERT]) in plasma and clinical variables and survival in a large-scale non-small cell lung cancer (..
  56. Liu T, Wang N, Cao J, Sofiadis A, Dinets A, Zedenius J, et al. The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas. Oncogene. 2014;33:4978-84 pubmed publisher
    Telomerase activation through induction of its catalytic component telomerase reverse transcriptase (TERT) expression is essential for malignant transformation...
  57. Terrin L, Dal Col J, Rampazzo E, Zancai P, Pedrotti M, Ammirabile G, et al. Latent membrane protein 1 of Epstein-Barr virus activates the hTERT promoter and enhances telomerase activity in B lymphocytes. J Virol. 2008;82:10175-87 pubmed publisher
  58. Venteicher A, Abreu E, Meng Z, McCann K, Terns R, Veenstra T, et al. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science. 2009;323:644-8 pubmed publisher
    ..Active human telomerase consists of at least three principal subunits, including the telomerase reverse transcriptase, the telomerase RNA (TERC), and dyskerin...
  59. Robart A, Collins K. Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants. J Biol Chem. 2010;285:4375-86 pubmed publisher
    ..Structure/function studies of disease-linked variants of human telomerase RNA (hTR) or telomerase reverse transcriptase (TERT) have exploited in vitro reconstitution of the enzyme catalytic core and/or a PCR-amplified ..
  60. Mukherjee S, Firpo E, Wang Y, Roberts J. Separation of telomerase functions by reverse genetics. Proc Natl Acad Sci U S A. 2011;108:E1363-71 pubmed publisher
    ..Thus, enhanced cell proliferation is an independent function of hTERT that could provide a new target for the development of anti-telomerase cancer therapeutic agents. ..
  61. Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki G. Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. PLoS ONE. 2013;8:e52989 pubmed publisher
    ..whether it is connected to telomere maintenance or is rather a non-telomeric function of the telomerase protein, TERT. It was shown recently that the protein subunit of telomerase can shuttle from the nucleus to the mitochondria upon ..
  62. Miller J, Dakic A, Chen R, Palechor Ceron N, Dai Y, Kallakury B, et al. HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. PLoS Pathog. 2013;9:e1003284 pubmed publisher
    Previous studies have shown that wild-type human telomerase reverse transcriptase (hTERT) protein can functionally replace the human papillomavirus type 16 (HPV-16) E6 protein, which cooperates with the viral E7 protein in the ..
  63. Wu R, Ayhan A, Maeda D, Kim K, Clarke B, Shaw P, et al. Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy. J Pathol. 2014;232:473-81 pubmed publisher
    Up-regulated expression of telomerase reverse transcriptase (TERT) and subsequent maintenance of telomere length are essential in tumour development...
  64. Lue N, Lin Y, Mian I. A conserved telomerase motif within the catalytic domain of telomerase reverse transcriptase is specifically required for repeat addition processivity. Mol Cell Biol. 2003;23:8440-9 pubmed
    ..The catalytic protein subunit of the telomerase complex, known as TERT, possesses a reverse transcriptase (RT) domain that mediates nucleotide addition...
  65. Renaud S, Loukinov D, Abdullaev Z, Guilleret I, Bosman F, Lobanenkov V, et al. Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene. Nucleic Acids Res. 2007;35:1245-56 pubmed
    ..In our model, hTERT methylation prevents binding of the CTCF repressor, but partial hypomethylation of the core promoter is necessary for hTERT expression. ..
  66. Armanios M, Chen J, Cogan J, Alder J, Ingersoll R, Markin C, et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med. 2007;356:1317-26 pubmed
    ..Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase and telomerase RNA, respectively, cause autosomal dominant dyskeratosis congenita, a rare hereditary ..
  67. Yang S, Fang D, Yang J, Chen L, Luo Y, Liang G. Antisense human telomerase reverse transcriptase could partially reverse malignant phenotypes of gastric carcinoma cell line in vitro. Eur J Cancer Prev. 2008;17:209-17 pubmed publisher
    ..Among three subunits of human telomerase, human telomerase reverse transcriptase (hTERT) is the rate-limiting component for telomerase activity...
  68. Liu Z, Li G, Wei S, Niu J, Wang L, Sturgis E, et al. Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. Carcinogenesis. 2010;31:1977-81 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T) at the 5p15...
  69. Leem S, Londono Vallejo J, Kim J, Bui H, Tubacher E, Solomon G, et al. The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions. Oncogene. 2002;21:769-77 pubmed
    ..This observation suggests that chromosomal rearrangements implicating these VNTRs may be associated with the activation of telomerase expression in cancer cells. ..
  70. Lee S, Kim J, Lee H, Cho Y, Oh S, Kim Y, et al. Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-gamma induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression. Oncogene. 2003;22:381-91 pubmed
    ..In this study, we show that IFN-gamma signaling represses telomerase activity and human telomerase reverse transcriptase (hTERT) transcription, and suggest that this signaling is mediated by IRF-1...
  71. Armbruster B, Linardic C, Veldman T, Bansal N, Downie D, Counter C. Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. Mol Cell Biol. 2004;24:3552-61 pubmed
    ..However, this rescue depended on the ability of hPot1 to localize to telomeres rather than binding to DNA per se. These data support a model whereby the DAT domain of hTERT is implicated in telomere-telomerase associations. ..
  72. Matthews C, Gorenne I, Scott S, Figg N, Kirkpatrick P, Ritchie A, et al. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress. Circ Res. 2006;99:156-64 pubmed
    ..Prevention of cellular senescence may be a novel therapeutic target in atherosclerosis. ..
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    ..core of human telomerase is postulated to contain two components, the telomerase RNA hTER and the telomerase reverse transcriptase hTERT...
  74. Drosopoulos W, Direnzo R, Prasad V. Human telomerase RNA template sequence is a determinant of telomere repeat extension rate. J Biol Chem. 2005;280:32801-10 pubmed
    ..Our results suggest that telomerase RNA template sequence is a key determinant of the contribution of telomerase to telomere length regulation. ..
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    ..These data demonstrate that targeted degradation of NFX1-91 by E6/E6AP dissociates the mSin3A/HDAC complex from the hTERT promoter and induces hTERT transcription. ..
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    We have cloned and characterized a human gene encoding TP2 (telomerase-associated protein 2), a protein with similarity to reverse transcriptases and the catalytic telomerase subunits from Saccharomyces cerevisiae and Euplotes ..
  77. Anderson C, Hoare S, Ashcroft M, Bilsland A, Keith W. Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms. Oncogene. 2006;25:61-9 pubmed
    ..These studies show that hTERT and hTR are subject to similar controls under hypoxia and highlight the rapid and dynamic regulation of the telomerase genes in vivo. ..
  78. D Souza Y, Chu T, Autexier C. A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. Mol Biol Cell. 2013;24:1469-79 pubmed publisher
    ..G-rich telomeric sequences are synthesized by telomerase, a ribonucleoprotein consisting of telomerase reverse transcriptase (TERT) and an integrally associated RNA...
  79. Zaug A, Crary S, Jesse Fioravanti M, Campbell K, Cech T. Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res. 2013;41:8969-78 pubmed publisher
    Mutations in the gene for telomerase reverse transcriptase (hTERT) are associated with diseases including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis and cancer...
  80. Wang L, Soria J, Chang Y, Lee H, Wei Q, Mao L. Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. Oncogene. 2003;22:7123-9 pubmed
    ..18; 95% confidence interval=0.92, 5.20) after adjustment for age, sex, ethnicity, and smoking status, suggesting a potential role of MNS16A in lung cancer susceptibility. Larger studies are needed to verify our findings. ..
  81. Kohno T, Kunitoh H, Shimada Y, Shiraishi K, Ishii Y, Goto K, et al. Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. Carcinogenesis. 2010;31:834-41 pubmed publisher
    ..DQA1*03 and the minor allele for a polymorphism, rs2736100, in TERT, another lung cancer susceptibility locus identified in recent GWASs on Europeans and Americans, were indicated to ..
  82. Kovalenko O, Caron M, Ulema P, Medrano C, Thomas A, Kimura M, et al. A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell. 2010;9:203-19 pubmed publisher
  83. Takakura M, Kyo S, Kanaya T, Hirano H, Takeda J, Yutsudo M, et al. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res. 1999;59:551-7 pubmed
    ..Of the three major subunits comprising human telomerase, human telomerase catalytic subunit (hTERT) has been shown to be a rate-limiting determinant of the enzymatic activity of human telomerase...
  84. Holt S, Glinsky V, Ivanova A, Glinsky G. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. Mol Carcinog. 1999;25:241-8 pubmed
    ..Taken together, these results provide the first direct experimental evidence supporting the hypothesis that telomerase activity and maintenance of telomere stability are associated with increased cellular resistance to apoptosis. ..
  85. Osterhage J, Friedman K. Chromosome end maintenance by telomerase. J Biol Chem. 2009;284:16061-5 pubmed publisher
    ..This minireview provides an overview of telomerase structure, function, and regulation and the role of telomerase in human disease. ..
  86. Zhang R, Zhao J, Yang L, Yang S, Wang R, Chen W, et al. RNA interference-mediated hTERT inhibition enhances TRAIL-induced apoptosis in resistant hepatocellular carcinoma cells. Oncol Rep. 2010;23:1013-9 pubmed
    ..It has been shown that human telomerase catalytic subunit (hTERT) is overexpressed in human HCCs...
  87. Won J, Yim J, Kim T. Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells. J Biol Chem. 2002;277:38230-8 pubmed
    ..cells, telomerase activity is tightly regulated by the expression of its catalytic subunit, human telomerase reverse transcriptase (hTERT)...
  88. Agarwal M, Pandita S, Hunt C, Gupta A, Yue X, Khan S, et al. Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization. Cancer Res. 2008;68:3370-8 pubmed publisher
    ..in enhanced hyperthermia-mediated IR-induced cell killing, and ectopic expression of catalytic unit of telomerase (TERT) decreased hyperthermia-mediated IR-induced cell killing...
  89. Catarino R, Araujo A, Coelho A, Gomes M, Nogueira A, Lopes C, et al. Prognostic significance of telomerase polymorphism in non-small cell lung cancer. Clin Cancer Res. 2010;16:3706-12 pubmed publisher
    ..The assessment of telomerase genetic variants could supplement prognosis of survival in the course of NSCLC and may be a promising molecular marker of treatment response in these patients. ..
  90. Won J, Yim J, Kim T. Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells. FASEB J. 2002;16:1943-5 pubmed
    ..Telomerase activity is tightly regulated by the expression of its catalytic subunit human telomerase reverse transcriptase (hTERT)...
  91. Melissourgos N, Kastrinakis N, Davilas I, Foukas P, Farmakis A, Lykourinas M. Detection of human telomerase reverse transcriptase mRNA in urine of patients with bladder cancer: evaluation of an emerging tumor marker. Urology. 2003;62:362-7 pubmed
    ..detection marker, we investigated the expression of the catalytic subunit of the complex (human telomerase reverse transcriptase [hTERT]) in the urine of patients with malignant or benign urinary lesions, as well as of healthy ..