TERT

Summary

Gene Symbol: TERT
Description: telomerase reverse transcriptase
Alias: CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase catalytic subunit, telomerase-associated protein 2
Species: human

Top Publications

  1. ncbi Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
    Janine Hertzog Santos
    Laboratory of Molecular Genetics, National Institute of Environmental and Health Sciences NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 15:1757-68. 2006
  2. pmc Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells
    Marcia Bellon
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kansas Medical Center, Kansas City, USA
    Blood 112:2946-55. 2008
  3. ncbi Extension of life-span by introduction of telomerase into normal human cells
    A G Bodnar
    Geron Corporation, Menlo Park, CA 94025, USA
    Science 279:349-52. 1998
  4. doi Genome-wide association study identifies five susceptibility loci for glioma
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 41:899-904. 2009
  5. doi Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
    Thorunn Rafnar
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 41:221-7. 2009
  6. pmc Lung cancer susceptibility locus at 5p15.33
    James D McKay
    International Agency for Research on Cancer IARC, Lyon, France
    Nat Genet 40:1404-6. 2008
  7. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
  8. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
  9. doi Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations
    Daiki Miki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:893-6. 2010
  10. pmc Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer
    Clare Turnbull
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 42:604-7. 2010

Research Grants

  1. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2007
  2. Regulation and Function of hTERT in Human Cells
    William C Hahn; Fiscal Year: 2010
  3. Defining the telomerase holoenzyme in progenitor cells with aging
    Steven E Artandi; Fiscal Year: 2010
  4. Structure and Behaviour of Yeast Telomeres
    Virginia A Zakian; Fiscal Year: 2010
  5. Structure and Behaviour of Yeast Telomeres
    Virginia A Zakian; Fiscal Year: 2011
  6. TELOMERE REPLICATION AND SENESCENCE IN YEAST
    Victoria Lundblad; Fiscal Year: 2001
  7. Telomeres, Telomerase and Tumor Progression
    Steven Artandi; Fiscal Year: 2009
  8. Telomeres, Telomerase and Tumor Progression
    Steven Artandi; Fiscal Year: 2009
  9. Herpesvirus-induced telomerase dysregulation and tumor formation
    Nikolaus Osterrieder; Fiscal Year: 2007
  10. Herpesvirus-induced telomerase dysregulation and tumor formation
    Keith William Jarosinski; Fiscal Year: 2010

Detail Information

Publications341 found, 100 shown here

  1. ncbi Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
    Janine Hertzog Santos
    Laboratory of Molecular Genetics, National Institute of Environmental and Health Sciences NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 15:1757-68. 2006
    ....
  2. pmc Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells
    Marcia Bellon
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kansas Medical Center, Kansas City, USA
    Blood 112:2946-55. 2008
    ..The importance of this regulatory pathway for telomerase expression is underscored by findings that the PI3K pathway is commonly found activated in cancer cells...
  3. ncbi Extension of life-span by introduction of telomerase into normal human cells
    A G Bodnar
    Geron Corporation, Menlo Park, CA 94025, USA
    Science 279:349-52. 1998
    ..pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomerase catalytic subunit. In contrast to telomerase-negative control clones, which exhibited telomere shortening and senescence, ..
  4. doi Genome-wide association study identifies five susceptibility loci for glioma
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 41:899-904. 2009
    ..We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7...
  5. doi Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
    Thorunn Rafnar
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 41:221-7. 2009
    ..However, neither variant could fully account for the association of the other. rs2736098 corresponds to A305A in the telomerase reverse transcriptase (TERT) protein and rs401681 is in an intron of the CLPTM1L gene.
  6. pmc Lung cancer susceptibility locus at 5p15.33
    James D McKay
    International Agency for Research on Cancer IARC, Lyon, France
    Nat Genet 40:1404-6. 2008
    ..016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.
  7. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
    ..In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR]=1...
  8. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  9. doi Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations
    Daiki Miki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:893-6. 2010
    ..The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10⁻¹¹), odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7...
  10. pmc Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer
    Clare Turnbull
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 42:604-7. 2010
    ..We identified two independent signals within the TERT-CLPTM1L locus on chromosome 5, which has previously been associated with multiple other cancers (rs4635969, OR=1...
  11. pmc New common variants affecting susceptibility to basal cell carcinoma
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:909-14. 2009
    ..Finally, we report conclusive evidence that rs401681[C] in the TERT-CLPTM1L locus confers susceptibility to BCC but protects against melanoma.
  12. pmc Telomere shortening in familial and sporadic pulmonary fibrosis
    Jennifer T Cronkhite
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Am J Respir Crit Care Med 178:729-37. 2008
    Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres.
  13. doi Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage
    Judith Haendeler
    Molecular Cardiology, Department of Internal Medicine III, Centre of Biological Chemistry, University of Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 29:929-35. 2009
    The enzyme telomerase and its catalytic subunit the telomerase reverse transcriptase (TERT) are important for maintenance of telomere length in the nucleus. Recent studies provided evidence for a mitochondrial localization of TERT...
  14. pmc Adult-onset pulmonary fibrosis caused by mutations in telomerase
    Kalliopi D Tsakiri
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:7552-7. 2007
    ..Sequencing a candidate gene within the interval, TERT, revealed a missense mutation and a frameshift mutation that cosegregated with pulmonary disease in the two ..
  15. doi Variation at the TERT locus and predisposition for cancer
    Duncan M Baird
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Expert Rev Mol Med 12:e16. 2010
    ..Here I review the evidence that variation at the 5p15.33 locus, which contains the TERT gene (encoding the catalytic subunit of telomerase), might play a role in the determination of cancer risk...
  16. doi Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Carcinogenesis 31:834-41. 2010
    ..DQA1*03 and the minor allele for a polymorphism, rs2736100, in TERT, another lung cancer susceptibility locus identified in recent GWASs on Europeans and Americans, were indicated to ..
  17. ncbi Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT
    Kei Haga
    Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuoku 104 0045, Tokyo, Japan
    Cancer Sci 98:147-54. 2007
    ..Subsequent introduction of hTERT, the telomerase catalytic subunit, into cells with low p16(INK4a) levels resulted in efficient immortalization of three cell types ..
  18. ncbi Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage
    Janine Hertzog Santos
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Natinoal Institutes of Health, 111, Alexander Drive, MD D3 01, Research Triangle Park, NC 27709, USA
    Aging Cell 3:399-411. 2004
    ..These results suggest that mitochondrial telomerase sensitizes cells to oxidative stress, which can lead to apoptotic cell death, and imply a novel function of telomerase in mitochondrial DNA transactions...
  19. ncbi Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1
    Leslie G Wooten-Blanks
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    FASEB J 21:3386-97. 2007
    ....
  20. ncbi Telomerase mutations in families with idiopathic pulmonary fibrosis
    Mary Y Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    N Engl J Med 356:1317-26. 2007
    ....
  21. pmc Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Manuela Gago-Dominguez
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9175, USA
    Carcinogenesis 32:197-202. 2011
    ..26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk...
  22. pmc Telomere length and genetic analyses in population-based studies of endometrial cancer risk
    Jennifer Prescott
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 116:4275-82. 2010
    ..When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic...
  23. ncbi Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor
    Basem S Goueli
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 22:8042-7. 2003
    ....
  24. pmc Combinations of newly confirmed Glioma-Associated loci link regions on chromosomes 1 and 9 to increased disease risk
    Tun Hsiang Yang
    Bioinformatics Program, Boston University, 24 Cummington Street, Boston, MA 02215, USA
    BMC Med Genomics 4:63. 2011
    ..The purpose of this paper is to present an improved approach to biomarker identification...
  25. pmc Genomic amplification of the human telomerase gene (hTERC) associated with human papillomavirus is related to the progression of uterine cervical dysplasia to invasive cancer
    Hongqian Liu
    Department of Obstetric and Gynecologic, West China Second University Hospital, Sichuan University, Chengdu 610041, China
    Diagn Pathol 7:147. 2012
    ..We were studying the role of hTERC in the progression of uterine cervical dysplasia to invasive cancer, and proposed an adjunct method for cervical cancer screening...
  26. doi Interaction between 5 genetic variants and allergy in glioma risk
    Minouk J Schoemaker
    Institute of Cancer Research, Sutton, United Kingdom
    Am J Epidemiol 171:1165-73. 2010
    ..Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13...
  27. doi Defining the pathogenic role of telomerase mutations in myelodysplastic syndrome and acute myeloid leukemia
    Michael Kirwan
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Barts and The London Children s Hospital, United Kingdom
    Hum Mutat 30:1567-73. 2009
    ..We have now identified novel mutations in the telomerase RNA (TERC) or telomerase reverse transcriptase component (TERT) within 4 of 20 families presenting with familial MDS/AML...
  28. pmc A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells
    Syed M Meeran
    Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall 175, Birmingham, AL 35294 1170, USA
    Cancer Prev Res (Phila) 4:1243-54. 2011
    ..Collectively, our data provide new insights into breast cancer prevention through epigenetic modulation of telomerase by using pro-EGCG, a more stable form of EGCG, as a novel chemopreventive compound...
  29. pmc The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity
    L M Colgin
    Children s Medical Research Institute, Westmead, New South Wales, Australia
    Neoplasia 2:426-32. 2000
    The telomerase catalytic subunit (hTERT) is an essential component of the holoenzyme complex that adds telomeric repeats to the ends of human chromosomes...
  30. doi hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells
    Inthrani R Indran
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cancer Res 71:266-76. 2011
    ....
  31. ncbi The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
    X Z Zhou
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA
    Cell 107:347-59. 2001
    ..PinX1 and its small TID domain bind the telomerase catalytic subunit hTERT and potently inhibit its activity...
  32. pmc Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e10680. 2010
    ..Rare loss of function mutations in the gene that encodes the protein component of telomerase (TERT) have been described in patients with idiopathic pulmonary fibrosis (IPF)...
  33. ncbi Regulation of telomerase by telomeric proteins
    Agata Smogorzewska
    The Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 73:177-208. 2004
    ..sequences that can be maintained by telomerase, a complex containing a reverse transcriptase (hTERT in humans and Est2 in budding yeast), a template RNA (hTERC in humans and Tlc1 in yeast), and accessory factors (the Est1 proteins and ..
  34. ncbi Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene
    I Horikawa
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 59:826-30. 1999
    ..Identification of the regulatory regions of the hTERT promoter sequence will be essential in understanding the molecular mechanisms of positive and negative regulation of telomerase...
  35. ncbi Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis
    Vera Gorbunova
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:38540-9. 2002
    ..We hypothesize that healing of DNA breaks by telomerase inhibits the induction of cell death, but because healing does not provide legitimate DNA repair, it does not protect cells from SIPS...
  36. doi Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population
    Guangfu Jin
    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, China
    Carcinogenesis 30:987-90. 2009
    Chromosome 5p15.33, containing TERT and CLPTM1L genes, was recently identified as one of the susceptible regions for lung cancer in Caucasian populations...
  37. doi TERT promotes cellular and organismal survival independently of telomerase activity
    J Lee
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
    Oncogene 27:3754-60. 2008
    The expression level of the telomerase catalytic subunit (telomerase reverse transcriptase, TERT) positively correlates with cell survival after exposure to several lethal stresses...
  38. ncbi Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
    C M Counter
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Oncogene 16:1217-22. 1998
    ..In humans, mRNA expression of hTERT (hEST2), the candidate telomerase catalytic subunit gene, appears to parallel the levels of telomerase enzyme activity, suggesting that induction of hTERT ..
  39. ncbi Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts
    G A Ulaner
    Veterans Affairs Palo Alto Health Care System, and Department of Medicine, Stanford University, California 94304, USA
    Cancer Res 58:4168-72. 1998
    ....
  40. pmc Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia
    Rodrigo T Calado
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:1187-92. 2009
    ..bone marrow samples from 133 consecutive patients with acute myeloid leukemia and 198 controls for variations in TERT and TERC genes...
  41. pmc A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
    Gloria M Petersen
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Nat Genet 42:224-8. 2010
    ..71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers...
  42. doi A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction
    Olga A Kovalenko
    Department of Pharmacology and Physiology, National Institute of Environmental and Health Sciences, 111 TW Alexander Dr, MD F0 02, Durham, NC 27709, USA
    Aging Cell 9:203-19. 2010
    ....
  43. pmc An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    Yoshiko Maida
    Cancer Stem Cell Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Nature 461:230-5. 2009
    ..However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres...
  44. pmc Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1
    Subhash C Verma
    Department of Microbiology and Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Virol 78:10348-59. 2004
    ..Together, our results suggest that the interaction of LANA with Sp1 up-regulates the telomerase promoter, potentially contributing to the immortalization of KSHV-infected cells...
  45. ncbi The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter
    Y S Cong
    Cancer Research Group, Department of Pathology and Molecular Medicine, McMaster University HSC 4H30, 120 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Hum Mol Genet 8:137-42. 1999
    ..The abundance of these sites suggests the possibility that hTERT expression may be subject to multiple levels of control and be regulated by different factors in different cellular contexts...
  46. doi Polymorphisms in telomere maintenance genes and risk of lung cancer
    Jin Eun Choi
    Department of Biochemistry, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700 412, Korea
    Cancer Epidemiol Biomarkers Prev 18:2773-81. 2009
    ..was conducted to comprehensively evaluate the associations between polymorphisms in telomere maintenance genes (TERT, TRF1, TNKS1, TRF2, RAP1, and POT1) and lung cancer risk...
  47. ncbi Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation
    Jing Lan
    Department of Pathology, Zhongnan Hospital, Wuhan University, Wuhan city 430071, Hubei Province, China
    World J Gastroenterol 9:54-8. 2003
    ..pylori infection...
  48. pmc Specificity requirements for human telomere protein interaction with telomerase holoenzyme
    Alec N Sexton
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 3200, USA
    J Biol Chem 287:34455-64. 2012
    ..which uses a template within its integral RNA subunit (hTR) and telomerase reverse transcriptase protein (TERT) to accomplish the synthesis of single-stranded DNA repeats...
  49. pmc Telomerase can act as a template- and RNA-independent terminal transferase
    Neal F Lue
    Department of Microbiology and Immunology, W R Hearst Microbiology Research Center, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:9778-83. 2005
    ..The terminal transferase activity of telomerase may account for some of the hitherto unexplained effects of telomerase overexpression on cell physiology...
  50. pmc MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells
    Shivani Ponnala
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA
    Cell Signal 23:2065-75. 2011
    ..Taken together, these data provide new insights into the mechanisms underlying MMP-9-mediated hTERT expression in glioma proliferation...
  51. pmc Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress
    Olga A Kovalenko
    Department of Pharmacology and Physiology, New Jersey Medical School, Newark, New Jersey, USA
    PLoS ONE 5:e10812. 2010
    ....
  52. pmc Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase
    Huira C Kopera
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 5618, USA
    Proc Natl Acad Sci U S A 108:20345-50. 2011
    ..Finally, we demonstrate that ORF1p is not strictly required for ENi retrotransposition at dysfunctional telomeres. Thus, these data further highlight similarities between the mechanism of ENi L1 retrotransposition and telomerase...
  53. pmc No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk
    Karen A Pooley
    Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory, 2 Worts Causeway, Cambridge CB18RN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:1862-5. 2010
    A recent study reported genetic variants in the TERT-CLPTM1L locus that were associated with mean telomere length, and with risk of multiple cancers.
  54. ncbi hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer
    Luo Wang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 8:2883-9. 2002
    ..hTERT may serve as a useful marker to identify patients with poor prognosis and to select patients with early-stage non-small cell lung cancer who might benefit from adjuvant treatment...
  55. pmc Pancreatic cancer susceptibility loci and their role in survival
    Cosmeri Rizzato
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 6:e27921. 2011
    ..Single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (NR5A2) were found to be associated with pancreatic cancer risk...
  56. ncbi hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
    M Meyerson
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Cell 90:785-95. 1997
    ..We report the cloning of a human gene, hEST2, that shares significant sequence similarity with the telomerase catalytic subunit genes of lower eukaryotes...
  57. ncbi Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
    M Wick
    Bayer AG, Central Research Division, Department of Molecular Biology, D 51368, Leverkusen, Germany
    Gene 232:97-106. 1999
    ..Altogether, these results provide the basis for more detailed studies on the regulation of telomerase activity in normal and cancer cells, and may lead to the development of new cancer therapies...
  58. doi A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese
    Zhibin Hu
    Department of Epidemiology and Biostatistics, Ministry of Education MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China
    Nat Genet 43:792-6. 2011
    ..0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1...
  59. doi Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers
    Yufei Wang
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Carcinogenesis 31:234-8. 2010
    Genome-wide association studies have provided evidence that common variation at 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) influences lung cancer risk...
  60. ncbi Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation
    Luo Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Clin Oncol 24:1627-32. 2006
    ..We investigated whether hTERT MNS16A variant genotype predicted survival in GBM patients...
  61. ncbi Nucleolar localization of hTERT protein is associated with telomerase function
    Yinhua Yang
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06536 0812, USA
    Exp Cell Res 277:201-9. 2002
    ..One is a reverse transcriptase subunit, TERT (telomerase reverse transcriptase); another is an RNA template subunit, TR (telomerase RNA)...
  62. ncbi Catalytically active human telomerase mutants with allele-specific biological properties
    Moses Kim
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143 2200, USA
    Exp Cell Res 288:277-87. 2003
    ..These results uncover further hTERT allele-specific phenotypes that uncouple telomerase activity, net telomere lengthening and life span extension...
  63. ncbi hTERT (-1327)T/C polymorphism is not associated with age-related telomere attrition in peripheral blood
    Katarina Nordfjäll
    Department of Medical Biosciences, Pathology, By 6M, 2nd Floor, Umea University, SE 90187 Umea, Sweden
    Biochem Biophys Res Commun 358:215-8. 2007
    Regulation of the telomerase catalytic subunit, hTERT, is a complex process accomplished on many levels. Transcription of the hTERT gene has been widely studied but less is known about the implication of genetic variations...
  64. ncbi Stable association of hsp90 and p23, but Not hsp70, with active human telomerase
    H L Forsythe
    Departments of Pathology and Human Genetics, Massey Cancer Center, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298 0662, USA
    J Biol Chem 276:15571-4. 2001
    ....
  65. pmc Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues
    Stein Saebøe-Larssen
    Section for Immunotherapy, Department of Immunology, The Norwegian Radium Hospital, Cancer Research Institute, University of Oslo, N 0310 Oslo, Norway
    BMC Mol Biol 7:26. 2006
    ..Knowledge of the different hTERT mRNA isoforms and the ability to distinguish between them is an important issue when evaluating telomerase expression...
  66. pmc NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes
    Mei Xu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 28:4819-28. 2008
    ..These data demonstrate that targeted degradation of NFX1-91 by E6/E6AP dissociates the mSin3A/HDAC complex from the hTERT promoter and induces hTERT transcription...
  67. ncbi Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase
    S Kharbanda
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 10:568-75. 2000
    ..Cloning and characterization of the human catalytic subunit of telomerase (hTERT) has supported a role in cell transformation. How telomerase activity is regulated, however, is largely unknown...
  68. pmc Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer
    C Q Zhu
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Ontario, Toronto, Canada
    Br J Cancer 94:1452-9. 2006
    ..16, P=0.03). These data indicate that gene amplification is an important mechanism for hTERT overexpression in lung adenocarcinoma and is an independent poor prognostic marker for disease-free survival in NSCLC...
  69. pmc Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Cell 132:945-57. 2008
    ..Three essential telomerase components have been identified thus far: the telomerase reverse transcriptase (TERT), the telomerase RNA component (TERC), and the TERC-binding protein dyskerin...
  70. ncbi TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
    Huawei Xin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 445:559-62. 2007
    ....
  71. ncbi IFN-gamma/IRF-1-induced p27kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer
    Seung Hoon Lee
    Molecular Therapy Research Center, School of Medicine, Sungkyunkwan University, Samsung Medical Center Annex 8F, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, Korea
    FEBS Lett 579:1027-33. 2005
    ..In conclusion, we propose that inhibition of the hTERT expression and telomerase activity may be a novel tumor suppressor function of p27...
  72. doi Relationship between tumor and plasma levels of hTERT mRNA in patients with colorectal cancer: implications for monitoring of neoplastic disease
    Liliana Terrin
    Department of Oncology and Surgical Sciences, Section of Oncology, University of Padova, Padova, Italy
    Clin Cancer Res 14:7444-51. 2008
    ..Expression of telomerase reverse transcriptase (hTERT) is essential to the oncogenic process and might be used as a molecular marker of neoplastic disease...
  73. ncbi Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths
    Ying Li Wu
    INSERM U685, Hopital Saint Louis, Institut d Hematologie, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Cell Sci 119:2797-806. 2006
    ..Our findings have interesting implications regarding the biology of nucleolin and telomerase in the context of pathophysiological investigations recently carried out...
  74. pmc Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL Inc, 5 6 50 Shin machi Hino, Tokyo, Japan
    Neoplasia 5:193-7. 2003
    ..Both gamma- and alpha-deletion variants were occasionally detected, but the beta-deletion variant was frequently observed. Our results may provide important information for more detailed studies on the regulation of telomerase activity...
  75. doi MNS16A minisatellite genotypes in relation to risk of glioma and meningioma and to glioblastoma outcome
    Ulrika Andersson
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Int J Cancer 125:968-72. 2009
    ..Collected data from our and previous studies regarding both risk and survival for the MNS16A genotypes are contradictory and warrant further investigations...
  76. doi Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells
    Yan min Zhao
    Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China
    Biochem Biophys Res Commun 369:1114-9. 2008
    ..These findings provide a profile of telomere regulation by cell cycle dependent expression of telomerase in hMSCs and may lead to a better understanding of the stem cell nature of these cells...
  77. pmc The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization
    David C F Sealey
    Department of Medical Biophysics, University of Toronto, Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario, M5G 2C1, Canada
    Nucleic Acids Res 38:2019-35. 2010
    ..The ability of telomerase to elongate single-stranded telomeric DNA depends on the reverse transcriptase domain of TERT, and also relies on protein:DNA contacts outside the active site...
  78. pmc Differentiating alternative splice variant patterns of human telomerase reverse transcriptase in thyroid neoplasms
    Yongchun Wang
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Thyroid 18:1055-63. 2008
    ....
  79. pmc C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity
    Soma S R Banik
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:6234-46. 2002
    ..While telomerase reverse transcriptase (TERT) is conserved in most eukaryotes, mounting evidence suggests that the C terminus of the human protein may have ..
  80. pmc A novel biomarker TERTmRNA is applicable for early detection of hepatoma
    Norimasa Miura
    Department of Pathophysiological and Therapeutic Science, Tottori University, Japan
    BMC Gastroenterol 10:46. 2010
    ..alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) are good markers for HCC. In this study, we verified the significance of hTERTmRNA in a large scale multi-centered trial, collating quantified values with clinical course...
  81. doi Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells
    Takahiro Eitsuka
    Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956 8603, Japan
    FEBS Lett 586:2542-7. 2012
    ..These results provide experimental evidence for a novel role of Amadori-PE in linking diabetes and cancer...
  82. pmc Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant
    Lisa F Lincz
    Department of Haematology, Calvary Mater Newcastle, Newcastle, NSW, Australia
    Neoplasia 10:1131-7. 2008
    ..This study shows that telomerase activity in melanoma cells is best determined by the absolute expression of full-length hTERT mRNA and indicates a role for the hTERT beta deletion variant in the negative regulation of enzyme activity...
  83. doi Changes of the alternative splicing variants of human telomerase reverse transcriptase during gastric carcinogenesis
    Jin heng Xu
    Department of Biochemistry and Molecular Biology, Tianjin Medical University, Heping District, Tianjin, China
    Pathobiology 76:23-9. 2009
    ..We attempted to reveal the changes of the human telomerase reverse transcriptase (hTERT) alternative splicing pattern in gastric carcinogenesis...
  84. pmc Significance of immunological detection of human telomerase reverse transcriptase: re-evaluation of expression and localization of human telomerase reverse transcriptase
    Satoru Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 163:859-67. 2003
    ..not all normal primary cells and telomerase-negative cancer cell lines lacked hTERT expression; some exhibited weak TERT signals...
  85. ncbi Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant
    Francois Delhommeau
    INSERM U362, PR 1, Institut Gustave Roussy, 39 53 rue Camille Desmoulins, 94805 Villejuif, France
    Oncogene 21:8262-71. 2002
    ....
  86. ncbi Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors
    Ryota Tomoda
    Department of Orthopedic Surgery, Mie University School of Medicine, Japan
    Cancer 95:1127-33. 2002
    ..Human telomerase reverse transcriptase (hTERT), a telomerase catalytic subunit, reportedly regulates telomerase activity...
  87. pmc Hypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes
    K H Shin
    School of Dentistry, University of California, Los Angeles, CA 90095, USA
    Br J Cancer 89:1473-8. 2003
    ..Our results suggest that hypermethylation of the hTERT promoter plays a critical role in the negative regulation of telomerase activity in normal human oral cells...
  88. ncbi Inhibitory effects of antisense phosphorothioate oligodeoxynucleotides on pancreatic cancer cell Bxpc-3 telomerase activity and cell growth in vitro
    Yun Feng Wang
    Department of General Surgery, The Center Hospital of Shanghai Yangpu District Branch Hospital of the Affiliated Xinhua Hospital of Shanghai Jiaotong University, Shanghai 200127, China
    World J Gastroenterol 12:4004-8. 2006
    ..To investigate the effect of telomerase hTERT gene antisense oligonucleotide (hTERT-ASO) on proliferation and telomerase activity of pancreatic cancer cell line Bxpc-3...
  89. ncbi Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective
    M P Mattson
    Laboratory of Neurosciences 4F02, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Mech Ageing Dev 122:659-71. 2001
    ..The catalytic subunit of telomerase (TERT) remains at relatively high levels during the process of neuronal differentiation and then decreases sharply during ..
  90. doi Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population
    Hongyan Chen
    State Key Laboratory of Genetic Engineering, Fudan VARI Genetic Epidemiology Center and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai200433, China
    Am J Epidemiol 173:915-22. 2011
    ..33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3...
  91. ncbi Changes of telomerase activity by alternative splicing of full-length and beta variants of hTERT in breast cancer patients
    Sun Young Rha
    Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
    Oncol Res 18:213-20. 2009
    ..027). Telomerase activity changed with alternative splicing of the full-length and beta variants expression of hTERT in breast cancer...
  92. doi Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells
    Wei Chen
    Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, China
    Cancer Sci 101:1769-76. 2010
    ..Thus, the findings in this study may help to improve telomerase-based therapy for cancer...
  93. doi Dual roles of a variable number of tandem repeat polymorphism in the TERT gene in lung cancer
    Guang Jin
    Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea
    Cancer Sci 102:144-9. 2011
    ..impact of a functional tandem repeat minisatellite (MNS16A) polymorphism in the telomerase reverse transcriptase (TERT) gene on the risk of lung cancer, as well as on survival of patients with non-small-cell lung cancer (NSCLC)...
  94. doi C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition
    Guoyuan Chen
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    Biochem Biophys Res Commun 398:683-9. 2010
    ..inhibitor composed of 328 amino acids, binds to the telomere associated protein Pin2/TRF1 and to the telomerase catalytic subunit hTERT. However, the mechanism by which LPTS/PinX1 regulates telomerase activity remains unclear...
  95. pmc A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer
    Luo Wang
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:3779-85. 2010
    ..It is unknown, however, whether or not the hTERT MNS16A variant genotype predicts survival of NSCLC patients...
  96. doi Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations
    R T Calado
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1202, USA
    Eur J Clin Invest 39:1025-32. 2009
    ..Telomeres are constituted of double-stranded tandem TTAGGG repeats followed by a 3' G-rich single-stranded overhang, a crucial telomeric structural component responsible for the t-loop formation...
  97. ncbi Reverse transcriptase motifs in the catalytic subunit of telomerase
    J Lingner
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
    Science 276:561-7. 1997
    ..A yeast (Saccharomyces cerevisiae) homolog was found and subsequently identified as EST2 (ever shorter telomeres), deletion of which had independently been shown to produce telomere defects...
  98. pmc Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation
    Aaron R Robart
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Mol Cell 42:308-18. 2011
    ..Notably, we find that complete single-repeat synthesis requires only a telomerase reverse transcriptase (TERT) core...
  99. pmc Direct involvement of the TEN domain at the active site of human telomerase
    Julie Jurczyluk
    Children s Medical Research Institute, Westmead, NSW 2145, Australia
    Nucleic Acids Res 39:1774-88. 2011
    ..The catalytic protein subunit of telomerase (TERT) contains an N-terminal domain (TEN) that is important for activity and processivity...
  100. pmc Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1
    Blaine N Armbruster
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:3552-61. 2004
    ..However, this rescue depended on the ability of hPot1 to localize to telomeres rather than binding to DNA per se. These data support a model whereby the DAT domain of hTERT is implicated in telomere-telomerase associations...
  101. ncbi Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT
    Yumiko Matsubara
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Biochem Biophys Res Commun 341:128-31. 2006
    ..0117). These findings suggest that the functional (-1327)T/C polymorphism of hTERT is associated with leukocyte telomere length in normal individuals...

Research Grants65

  1. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2007
    ..consists of telomerase RNA, encoded by the TLC1 gene, and the catalytic reverse transcriptase, encoded by EST2. Cdcl3p, which binds the single strand TGI__ tails at the very ends of yeast chromosomes is also essential for ..
  2. Regulation and Function of hTERT in Human Cells
    William C Hahn; Fiscal Year: 2010
    ..Moreover, mutations of telomerase components required for catalytic activity, TERT and TERC, are found in diseases characterized by stem cell failure including dyskeratosis congenita, subsets of ..
  3. Defining the telomerase holoenzyme in progenitor cells with aging
    Steven E Artandi; Fiscal Year: 2010
    ..behaves as a very large complex, only three components of the telomerase holoenzyme were identified until recently: TERT, the telomerase reverse transcriptase, TERC, the telomerase RNA component, and dyskerin, a TERC-binding protein...
  4. Structure and Behaviour of Yeast Telomeres
    Virginia A Zakian; Fiscal Year: 2010
    ..Telomerase action in S. cerevisiae in vivo requires at least five genes, EST1, EST2, EST3, TLC1 and CDC13...
  5. Structure and Behaviour of Yeast Telomeres
    Virginia A Zakian; Fiscal Year: 2011
    ..Telomerase action in S. cerevisiae in vivo requires at least five genes, EST1, EST2, EST3, TLC1 and CDC13...
  6. TELOMERE REPLICATION AND SENESCENCE IN YEAST
    Victoria Lundblad; Fiscal Year: 2001
    ..The genetic screen resulted in identification of two new EST genes (EST2 and EST3) as well as a novel est-like mutation in a gene previously implicated at the telomere (CDC13)...
  7. Telomeres, Telomerase and Tumor Progression
    Steven Artandi; Fiscal Year: 2009
    ..We have developed a sophisticated mouse model system to directly test these hypotheses using a novel allele of TERT, the catalytic component of telomerase that can be reactivated...
  8. Telomeres, Telomerase and Tumor Progression
    Steven Artandi; Fiscal Year: 2009
    ..We have developed a sophisticated mouse model system to directly test these hypotheses using a novel allele of TERT, the catalytic component of telomerase that can be reactivated...
  9. Herpesvirus-induced telomerase dysregulation and tumor formation
    Nikolaus Osterrieder; Fiscal Year: 2007
    ..Telomerase is a ribonucleoprotein complex with its core constituents being telomerase reverse transcriptase (TERT) and telomerase RNA (TR)...
  10. Herpesvirus-induced telomerase dysregulation and tumor formation
    Keith William Jarosinski; Fiscal Year: 2010
    ..Telomerase is a ribonucleoprotein complex with its core constituents being telomerase reverse transcriptase (TERT) and telomerase RNA (TR)...
  11. Structure and dynamics of the Tetrahymena telomerase ribonucleoprotein
    Michael D Stone; Fiscal Year: 2011
    ..that requires a strong functional interdependence of the telomerase RNA, telomerase reverse transcriptase (TERT), and several additional protein subunits...
  12. Structure and Function of Human Telomerase
    JULI F FEIGON; Fiscal Year: 2010
    ..a large RNA (TR) (451 nt in humans) that includes an RNA template and a unique telomerase reverse transcriptase (TERT), as well as other proteins important for function in vivo...
  13. Structure and Function of Human Telomerase
    Juli Feigon; Fiscal Year: 2009
    ..a large RNA (TR) (451 nt in humans) that includes an RNA template and a unique telomerase reverse transcriptase (TERT), as well as other proteins important for function in vivo...
  14. STRUCTURE AND BEHAVIOR OF YEAST TELOMERES
    Virginia Zakian; Fiscal Year: 2006
    ..consists of telomerase RNA, encoded by the TLC1 gene, and the catalytic reverse transcriptase, encoded by EST2. Cdcl3p, which binds the single strand TG1-3 tails at the very ends of yeast chromosomes is also essential for ..
  15. Biogenesis and Regulation of Human Telomerase
    Kathleen Collins; Fiscal Year: 2010
    ..This RNP then recruits telomerase reverse transcriptase (TERT) to generate the active enzyme...
  16. Regulation of the Telomerase Protein Component In Cancer
    Steven Artandi; Fiscal Year: 2007
    ..In mediating the ability of cancer cells to proliferate in an immortal fashion, telomerase requires both TERT, the telomerase protein component, and TERC, the telomerase RNA component, which together add telomere sequences to ..
  17. Regulation of the Telomerase Protein Component In Cancer
    Steven E Artandi; Fiscal Year: 2010
    ..In mediating the ability of cancer cells to proliferate in an immortal fashion, telomerase requires both TERT, the telomerase protein component, and TERC, the telomerase RNA component, which together add telomere sequences to ..
  18. Telomerase RNA Transfected Dendritic Cell Vaccines
    Johannes Vieweg; Fiscal Year: 2005
    ..patients by inducing immunity against the protein subunit of human telomerase, telomerase reverse transcriptase (TERT)...
  19. CANCER VACCINATION AGAINST TELOMERASE
    Eli Gilboa; Fiscal Year: 2005
    ..The polypeptide component of telomerase, also know as telomerase reverse transcriptase or TERT, is an attractive candidate for a broadly expressed tumor antigen since telomerase is silent in normal tissues but ..
  20. The Function of Telomerase and Telomeres
    Elizabeth Blackburn; Fiscal Year: 2006
    ..We will determine the roles of specific residues and domains of the telomerase RNA (TLC1) and TERT (Est2p) in functions of yeast telomerase, including its dimerization and a newly-charactedzed functional protection ..
  21. Telomerase Specific Caspase Transfer for Gliomas
    Seiji Kondo; Fiscal Year: 2004
    ..Activation of telomerase is tightly regulated at the transcriptional level of the telomerase catalytic subunit (hTERT)...
  22. Structure of ribonucleoprotein: telomerase
    Gabriele Varani; Fiscal Year: 2007
    ..The enzymatic activity of telomerase (TERT) is homologous to viral reverse transcriptases, while the RNA (TER) provides the template and a landing dock for ..
  23. Regulation and Function of Telomerase in Human Cells
    William Hahn; Fiscal Year: 2007
    ..However, we have recently found that the rate-limiting telomerase catalytic subunit, hTERT, is expressed in cycling primary human fibroblasts, previously believed to be devoid of ..
  24. Telomerase in Inflammation and Atherosclerosis
    Dennis Bruemmer; Fiscal Year: 2009
    ..Stem cells constitutively overexpress the catalytic core telomerase reverse transcriptase (TERT) manifesting high levels of telomerase activity, which confers an apparently indefinite lifespan and is rate ..
  25. Telomerase in Inflammation and Atherosclerosis
    DENNIS CHRISTOPHER BRUEMMER; Fiscal Year: 2010
    ..Stem cells constitutively overexpress the catalytic core telomerase reverse transcriptase (TERT) manifesting high levels of telomerase activity, which confers an apparently indefinite lifespan and is rate ..
  26. Telomerase and Telomeres: Structure, Function and Regulation
    Thomas Cech; Fiscal Year: 2009
    ..reactivation of telomerase; thus, there is substantial interest in anti-telomerase chemotherapeutic agents and in TERT (telomerase reverse transcriptase) as an antigen for cancer vaccines...