TERT

Summary

Gene Symbol: TERT
Description: telomerase reverse transcriptase
Alias: CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, telomerase catalytic subunit, telomerase-associated protein 2
Species: human
Products:     TERT

Top Publications

  1. Myneni A, Chang S, Niu R, Liu L, Ochs Balcom H, Li Y, et al. Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population. Lung Cancer. 2013;80:131-7 pubmed publisher
    Genetic variants of telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like (CLPTM1L) genes in chromosome 5p15.33 region were previously identified to influence the susceptibility to lung cancer...
  2. Calado R, Brudno J, Mehta P, Kovacs J, Wu C, Zago M, et al. Constitutional telomerase mutations are genetic risk factors for cirrhosis. Hepatology. 2011;53:1600-7 pubmed publisher
    ..University of Arizona, between May 2008 and July 2009, and 528 healthy subjects were screened for variation in the TERT and TERC genes by direct sequencing; an additional 1,472 controls were examined for the most common genetic ..
  3. Huang F, Hodis E, Xu M, Kryukov G, Chin L, Garraway L. Highly recurrent TERT promoter mutations in human melanoma. Science. 2013;339:957-9 pubmed publisher
    ..Here, we describe two independent mutations within the core promoter of telomerase reverse transcriptase (TERT), the gene coding for the catalytic subunit of telomerase, which collectively occur in 50 of 70 ..
  4. Haiman C, Chen G, Vachon C, Canzian F, Dunning A, Millikan R, et al. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet. 2011;43:1210-4 pubmed publisher
    ..We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10))...
  5. Shen J, Gammon M, Wu H, Terry M, Wang Q, Bradshaw P, et al. Multiple genetic variants in telomere pathway genes and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2010;19:219-28 pubmed publisher
    ..05. The top three statistically significant SNPs under a dominant model were TERT-07 (rs2736109), TERT-54 (rs3816659), and POT1-03 (rs33964002). The odds ratios (OR) were 1...
  6. Petersen G, Amundadottir L, Fuchs C, Kraft P, Stolzenberg Solomon R, Jacobs K, et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010;42:224-8 pubmed publisher
    ..71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers...
  7. Hosgood H, Cawthon R, He X, Chanock S, Lan Q. Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. Lung Cancer. 2009;66:157-61 pubmed publisher
    ..length separately and in conjunction with single nucleotide polymorphisms in the telomere maintenance genes POT1, TERT, and TERF2, which we have previously reported were associated with risk of lung cancer in this study...
  8. Bojesen S, Pooley K, Johnatty S, Beesley J, Michailidou K, Tyrer J, et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 2013;45:371-84, 384e1-2 pubmed publisher
    b>TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers...
  9. Turnbull C, Rapley E, Seal S, Pernet D, Renwick A, Hughes D, et al. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat Genet. 2010;42:604-7 pubmed publisher
    ..We identified two independent signals within the TERT-CLPTM1L locus on chromosome 5, which has previously been associated with multiple other cancers (rs4635969, OR=1...

More Information

Publications170 found, 100 shown here

  1. Fingerlin T, Murphy E, Zhang W, Peljto A, Brown K, Steele M, et al. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet. 2013;45:613-20 pubmed publisher
    ..We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2...
  2. Maida Y, Yasukawa M, Okamoto N, Ohka S, Kinoshita K, Totoki Y, et al. Involvement of telomerase reverse transcriptase in heterochromatin maintenance. Mol Cell Biol. 2014;34:1576-93 pubmed publisher
    ..In association with the telomerase RNA component (TERC), the telomerase reverse transcriptase (TERT) forms telomerase and counteracts telomere attrition, and without TERC, TERT has been ..
  3. Heidenreich B, Nagore E, Rachakonda P, Garcia Casado Z, Requena C, Traves V, et al. Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma. Nat Commun. 2014;5:3401 pubmed publisher
    ..somatic mutations in metastasized tumours from unrelated patients in the core promoter region of the telomerase reverse transcriptase (TERT) gene...
  4. Li Y, Tergaonkar V. Noncanonical functions of telomerase: implications in telomerase-targeted cancer therapies. Cancer Res. 2014;74:1639-44 pubmed publisher
    ..This review summarizes recent insights to the noncanonical functions of telomerase reverse transcriptase (TERT) catalytic subunit, in particular in cancer progression, and highlights two major signaling ..
  5. Heidenreich B, Rachakonda P, Hemminki K, Kumar R. TERT promoter mutations in cancer development. Curr Opin Genet Dev. 2014;24:30-7 pubmed publisher
    Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of telomerase that maintains genomic integrity...
  6. Pópulo H, Boaventura P, Vinagre J, Batista R, Mendes A, Caldas R, et al. TERT promoter mutations in skin cancer: the effects of sun exposure and X-irradiation. J Invest Dermatol. 2014;134:2251-2257 pubmed publisher
    The reactivation or reexpression of telomerase (TERT) is a widespread feature of neoplasms. TERT promoter mutations were recently reported that were hypothesized to result from UV radiation...
  7. Killela P, Pirozzi C, Healy P, Reitman Z, Lipp E, Rasheed B, et al. Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas. Oncotarget. 2014;5:1515-25 pubmed
    Frequent mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and the promoter of telomerase reverse transcriptase (TERT) represent two significant discoveries in glioma genomics...
  8. Wang N, Liu T, Sofiadis A, Juhlin C, Zedenius J, Höög A, et al. TERT promoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA. Cancer. 2014;120:2965-79 pubmed publisher
    The telomerase reverse transcriptase (TERT) promoter mutations C228T and C250T have been found in many malignancies, including in thyroid carcinomas. However, it is unclear how early these mutations occur in thyroid tumorigenesis...
  9. Xing M, Liu R, Liu X, Murugan A, Zhu G, Zeiger M, et al. BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. J Clin Oncol. 2014;32:2718-26 pubmed publisher
    To investigate the prognostic value of the BRAF V600E mutation and the recently identified TERT promoter mutation chr5:1,295,228C>T (C228T), individually and in their coexistence, in papillary thyroid cancer (PTC)...
  10. Xie H, Liu T, Wang N, Björnhagen V, Höög A, Larsson C, et al. TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinoma. Oncotarget. 2014;5:10048-57 pubmed
    Telomerase activation through the induction of its catalytic component TERT is essential in carcinogenesis...
  11. Wang K, Liu T, Liu L, Liu J, Liu C, Wang C, et al. TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas. Oncotarget. 2014;5:1829-36 pubmed
    b>TERT promoter mutations are identified in many malignancies including bladder cancer (BC) and upper tract urothelial carcinoma (UTUC). In contrast, no mutations were found in renal cell carcinoma (RCC) as reported in a recent study...
  12. Xi L, Cech T. Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT. Nucleic Acids Res. 2014;42:8565-77 pubmed publisher
    ..levels of the human telomerase RNP and its two key components, human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT)...
  13. Chatagnon A, Bougel S, Perriaud L, Lachuer J, Benhattar J, Dante R. Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells. Carcinogenesis. 2009;30:28-34 pubmed publisher
    Human telomerase reverse transcriptase (hTERT) is expressed in most cancer cells. Paradoxically, its promoter is embedded in a hypermethylated CpG island. A short region escapes to this alteration, allowing a basal level of transcription...
  14. Zhang Y, Toh L, Lau P, Wang X. Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/?-catenin pathway in human cancer. J Biol Chem. 2012;287:32494-511 pubmed
    ..The human telomerase reverse transcriptase (hTERT) promoter has been shown to promote hTERT gene expression selectively in tumor cells but not ..
  15. Rafnar T, Sulem P, Stacey S, Geller F, Gudmundsson J, Sigurdsson A, et al. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet. 2009;41:221-7 pubmed publisher
    ..However, neither variant could fully account for the association of the other. rs2736098 corresponds to A305A in the telomerase reverse transcriptase (TERT) protein and rs401681 is in an intron of the CLPTM1L gene.
  16. Höfer P, Baierl A, Feik E, Führlinger G, Leeb G, Mach K, et al. MNS16A tandem repeats minisatellite of human telomerase gene: a risk factor for colorectal cancer. Carcinogenesis. 2011;32:866-71 pubmed publisher
    Telomerase reactivation and expression of human telomerase gene [human telomerase reverse transcriptase (hTERT)] are hallmarks of unlimited proliferation potential of cancer cells...
  17. Nault J, Mallet M, Pilati C, Calderaro J, Bioulac Sage P, Laurent C, et al. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions. Nat Commun. 2013;4:2218 pubmed publisher
  18. Lingner J, Hughes T, Shevchenko A, Mann M, Lundblad V, Cech T. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science. 1997;276:561-7 pubmed
    ..A yeast (Saccharomyces cerevisiae) homolog was found and subsequently identified as EST2 (ever shorter telomeres), deletion of which had independently been shown to produce telomere defects...
  19. Redon S, Reichenbach P, Lingner J. Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Res. 2007;35:7011-22 pubmed
    ..establishes in addition RNase-resistant and hTR-independent protein-protein contacts with the human telomerase reverse transcriptase polypeptide (TERT)...
  20. McKay J, Hung R, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, et al. Lung cancer susceptibility locus at 5p15.33. Nat Genet. 2008;40:1404-6 pubmed publisher
    ..016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.
  21. Moriarty T, Ward R, Taboski M, Autexier C. An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization. Mol Biol Cell. 2005;16:3152-61 pubmed
    ..It has been proposed that repeat addition processivity is partly regulated by a telomerase reverse transcriptase (TERT)-dependent anchor site; however, anchor site-mediating residues have not been identified in any ..
  22. Stacey S, Sulem P, Masson G, Gudjonsson S, Thorleifsson G, Jakobsdottir M, et al. New common variants affecting susceptibility to basal cell carcinoma. Nat Genet. 2009;41:909-14 pubmed publisher
    ..Finally, we report conclusive evidence that rs401681[C] in the TERT-CLPTM1L locus confers susceptibility to BCC but protects against melanoma.
  23. Parry E, Alder J, Qi X, Chen J, Armanios M. Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood. 2011;117:5607-11 pubmed publisher
    ..This diagnosis affects the choice of bone marrow transplantation preparative regimen and can prevent morbidity. ..
  24. Zhao Z, Li C, Yang L, Zhang X, Zhao X, Song X, et al. Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population. Exp Lung Res. 2013;39:91-8 pubmed publisher
    ..33 region containing telomerase reverse transcriptase gene (TERT) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) gene showed significant ..
  25. Wang H, Zhang X, Jin B. TERT genetic polymorphism rs2736100 was associated with lung cancer: a meta-analysis based on 14,492 subjects. Genet Test Mol Biomarkers. 2013;17:937-41 pubmed publisher
    Previous studies focused on the association of the telomerase reverse transcriptase (TERT) gene polymorphism rs2736100 with lung cancer did not reach the same conclusion...
  26. Liu Z, Li Q, Li K, Chen L, Li W, Hou M, et al. Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells. Oncogene. 2013;32:4203-13 pubmed publisher
    Telomerase activation through induction of telomerase reverse transcriptase (hTERT) contributes to malignant transformation by stabilizing telomeres...
  27. Zienolddiny S, Skaug V, Landvik N, Ryberg D, Phillips D, Houlston R, et al. The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. Carcinogenesis. 2009;30:1368-71 pubmed publisher
    Genome-wide association studies have provided evidence that common variation at 5p15.33 [telomerase reverse transcriptase (TERT)-cleft lip and palate transmembrane 1-like (CLPTM1L)], 6p21.33 and 15q25...
  28. Zhou L, Zheng D, Wang M, Cong Y. Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity. Biochem Biophys Res Commun. 2009;386:739-43 pubmed publisher
    ..These results suggest that hTERT has non-telomeric activity in the regulation of gene expression and provide additional insights into the role of telomerase in aging and cancer. ..
  29. Stern J, Zyner K, Pickett H, Cohen S, Bryan T. Telomerase recruitment requires both TCAB1 and Cajal bodies independently. Mol Cell Biol. 2012;32:2384-95 pubmed publisher
    ..Our results demonstrate that telomerase has multiple independent requirements for recruitment to telomeres and that the function of TCAB1 is to directly transport telomerase to telomeres. ..
  30. Lan Q, Cawthon R, Gao Y, Hu W, Hosgood H, Barone Adesi F, et al. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS ONE. 2013;8:e59230 pubmed publisher
    ..study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism in the TERT-CLPTM1L locus on chromosome 5p15...
  31. Yang X, Yang B, Li B, Liu Y. Association between TERT-CLPTM1L rs401681[C] allele and NMSC cancer risk: a meta-analysis including 45,184 subjects. Arch Dermatol Res. 2013;305:49-52 pubmed publisher
    ..T, OR 1.15, 95 % CI 1.06-1.26) and non-Icelanders (C vs. T, OR 1.13, 95 % CI 1.03-1.24). In the subtype analysis, we found that rs401681[C] allele was a risk factor for BCC, but not SCC in the overall subjects. ..
  32. Kang S, Kwon T, Kwon D, Do S. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J Biol Chem. 1999;274:13085-90 pubmed
    ..two putative Akt kinase phosphorylation sites (220GARRRGGSAS229) and (817AVRIRGKSYV826) in human telomerase reverse transcriptase (hTERT) subunit...
  33. Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns R, et al. TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol Cell Biol. 2010;30:2971-82 pubmed publisher
  34. Gago Dominguez M, Jiang X, Conti D, Castelao J, Stern M, Cortessis V, et al. Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis. 2011;32:197-202 pubmed publisher
    ..26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk. ..
  35. Ueda Y, Hiyama E, Kamimatsuse A, Kamei N, Ogura K, Sueda T. Wnt signaling and telomerase activation of hepatoblastoma: correlation with chemosensitivity and surgical resectability. J Pediatr Surg. 2011;46:2221-7 pubmed publisher
    ..deletions in the third exon) of the CTNNB1 gene-encoding ?-catenin and for the expression levels of telomerase reverse transcriptase (TERT). Oncogenic mutations of CTNNB1 were detected in 42 cases (75%)...
  36. Mushiroda T, Wattanapokayakit S, Takahashi A, Nukiwa T, Kudoh S, Ogura T, et al. A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. J Med Genet. 2008;45:654-6 pubmed publisher
    ..replication sample set (83 cases and 535 controls) and found a significant association of an SNP in intron 2 of the TERT gene (rs2736100), which encodes a reverse transcriptase that is a component of a telomerase, with IPF; a ..
  37. Wang L, Wang L, Mao L, Spitz M, Wei Q. A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer. Clin Cancer Res. 2010;16:3779-85 pubmed publisher
    ..021 for trend test). These findings were not evident in 587 patients with stage III or IV NSCLC. The functional MNS16A-SS genotype may be a marker for poorer survival in early-stage NSCLC. ..
  38. Guo X, Wang W, Zhou F, Lu Z, Fang R, Jia F, et al. siRNA-mediated inhibition of hTERT enhances chemosensitivity of hepatocellular carcinoma. Cancer Biol Ther. 2008;7:1555-60 pubmed
    ..Our results demonstrated the synergistic effect between hTERT siRNA and cisplatin in the suppression of HCC progression and indicated that the combination of hTERT-specific siRNA and cisplatin could be an effective therapy for HCC. ..
  39. Masutomi K, Yu E, Khurts S, Ben Porath I, Currier J, Metz G, et al. Telomerase maintains telomere structure in normal human cells. Cell. 2003;114:241-53 pubmed
    ..Here, we demonstrate that the rate-limiting telomerase catalytic subunit hTERT is expressed in cycling primary presenescent human fibroblasts, previously believed to lack hTERT ..
  40. Burnworth B, Arendt S, Muffler S, Steinkraus V, Brocker E, Birek C, et al. The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1. Eur J Cell Biol. 2007;86:763-80 pubmed
    ..e. the angiogenic switch) required for malignant growth. ..
  41. Castelo Branco P, Choufani S, Mack S, Gallagher D, Zhang C, Lipman T, et al. Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. Lancet Oncol. 2013;14:534-42 pubmed publisher
    ..We investigated whether methylation of the TERT promoter can be a biomarker for malignancy and patient outcome in paediatric brain tumours...
  42. Lei M, Zaug A, Podell E, Cech T. Switching human telomerase on and off with hPOT1 protein in vitro. J Biol Chem. 2005;280:20449-56 pubmed
    ..Thus, depending on its location relative to the DNA 3'-end, hPOT1 can either inhibit telomerase action or form a preferred substrate for telomerase. We propose that another factor catalyzes the interconversion of these states in vivo. ..
  43. Chen Y, Campbell H, Wiles A, Eccles M, Reddel R, Braithwaite A, et al. PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Res. 2008;68:5724-32 pubmed publisher
    ..97, P = 0.0025). We found that PAX8 is able to coordinately transactivate the promoter for both the telomerase catalytic subunit (hTERT) and the telomerase RNA component (hTR) genes...
  44. Miki D, Kubo M, Takahashi A, Yoon K, Kim J, Lee G, et al. Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet. 2010;42:893-6 pubmed publisher
    ..The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10?¹¹), odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7...
  45. Snow B, Erdmann N, Cruickshank J, Goldman H, Gill R, Robinson M, et al. Functional conservation of the telomerase protein Est1p in humans. Curr Biol. 2003;13:698-704 pubmed
    Eukaryotic telomerase contains a telomerase reverse transcriptase (TERT) and an RNA template component that are essential for telomerase catalytic activity and several other telomerase-associated factors of which only a few appear to be ..
  46. Lopatina N, Poole J, Saldanha S, Hansen N, Key J, Pita M, et al. Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. Biochem Biophys Res Commun. 2003;306:650-9 pubmed
    ..These studies suggest that histone deacetylation is involved in early hTERT gene down-regulation and that DNA methylation may maintain silencing of the hTERT gene in these cells...
  47. Rha S, Jeung H, Park K, Kim J, Chung H. Changes of telomerase activity by alternative splicing of full-length and beta variants of hTERT in breast cancer patients. Oncol Res. 2009;18:213-20 pubmed
    Human telomerase reverse transcriptase (hTERT) expression level may not always correlate with telomerase activity...
  48. Chen H, Chen Y, Zhao Y, Fan W, Zhou K, Liu Y, et al. Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population. Am J Epidemiol. 2011;173:915-22 pubmed publisher
    ..33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3...
  49. Li A, Lin H, Kuo C, Shih H, Wang C, Yen Y, et al. High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. Mol Cell Biol. 2011;31:2605-17 pubmed publisher
    ..Our study reveals a novel link between HMGA2 and the regulation of human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, which offers critical insight into how HMGA2 ..
  50. Forsythe H, Jarvis J, Turner J, Elmore L, Holt S. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J Biol Chem. 2001;276:15571-4 pubmed
  51. Renaud S, Bosman F, Benhattar J. Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter. Biochem Biophys Res Commun. 2003;300:47-54 pubmed
    ..These results provide the first evidence that the first two exons play a major role in the down-regulation of the hTERT promoter in telomerase-positive cells. ..
  52. Baird D. Variation at the TERT locus and predisposition for cancer. Expert Rev Mol Med. 2010;12:e16 pubmed publisher
    ..Here I review the evidence that variation at the 5p15.33 locus, which contains the TERT gene (encoding the catalytic subunit of telomerase), might play a role in the determination of cancer risk...
  53. Wang S, Wu J, Hu L, Ding C, Kan Y, Shen Y, et al. Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population. Mol Carcinog. 2012;51 Suppl 1:E118-22 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) of TERT rs2736098, rs2736100, and CLPTM1L rs402710 at 5p15.33 are significantly associated with risk of a spectrum of cancers. However, cervical cancer has been rarely evaluated...
  54. Ulaner G, Hu J, Vu T, Giudice L, Hoffman A. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 1998;58:4168-72 pubmed
    ..we examined telomerase activity and the expression of the human telomerase RNA subunit and the human telomerase reverse transcriptase protein (hTERT) during human fetal heart, liver, and kidney development...
  55. Shats I, Milyavsky M, Tang X, Stambolsky P, Erez N, Brosh R, et al. p53-dependent down-regulation of telomerase is mediated by p21waf1. J Biol Chem. 2004;279:50976-85 pubmed
    ..in various cancer cell lines through transcriptional repression of its catalytic subunit, human telomerase reverse transcriptase (hTERT)...
  56. Lechel A, Holstege H, Begus Y, Schienke A, Kamino K, Lehmann U, et al. Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology. 2007;132:1465-75 pubmed
    ..The function of telomerase during in vivo hepatocarcinogenesis has not been studied in this genetic context...
  57. Janknecht R. On the road to immortality: hTERT upregulation in cancer cells. FEBS Lett. 2004;564:9-13 pubmed
    ..due to the transcriptional upregulation of the limiting component of telomerase, hTERT (human telomerase reverse transcriptase)...
  58. Alder J, Cogan J, Brown A, Anderson C, Lawson W, Lansdorp P, et al. Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PLoS Genet. 2011;7:e1001352 pubmed publisher
    The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by copying from a short template within its integral RNA component...
  59. March Villalba J, Martínez Jabaloyas J, Herrero M, Santamaría J, Aliño S, Dasi F. Plasma hTERT mRNA discriminates between clinically localized and locally advanced disease and is a predictor of recurrence in prostate cancer patients. Expert Opin Biol Ther. 2012;12 Suppl 1:S69-77 pubmed publisher
    ..Plasma telomerase reverse transcriptase (hTERT) mRNA levels were determined by qRT-PCR in 49 patients with localized and locally advanced PCa...
  60. Jung H, Wang X, Jun S, Park J. Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. J Biol Chem. 2013;288:7252-62 pubmed publisher
    ..Dyrk2 phosphorylates TERT protein, a catalytic subunit of telomerase...
  61. Kote Jarai Z, Olama A, Giles G, Severi G, Schleutker J, Weischer M, et al. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet. 2011;43:785-91 pubmed publisher
    ..0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported...
  62. Yamashita S, Ogawa K, Ikei T, Udono M, Fujiki T, Katakura Y. SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene. Biochem Biophys Res Commun. 2012;417:630-4 pubmed publisher
    ..Here, we focused on the human telomerase reverse transcriptase (hTERT) gene as a target of the SIRT1-induced prevention of cellular senescence...
  63. Liu H, Liu S, Wang H, Xie X, Chen X, Zhang X, et al. Genomic amplification of the human telomerase gene (hTERC) associated with human papillomavirus is related to the progression of uterine cervical dysplasia to invasive cancer. Diagn Pathol. 2012;7:147 pubmed publisher
    ..analyze telomerase activity by telomeric repeat amplification protocol (TRAP) and expression of human telomerase reverse transcriptase (hTERT), with immunohistochemistry (IHC). All biopsies were clinically confirmed by phathologists...
  64. Walsh K, Gorlov I, Hansen H, Wu X, Spitz M, Zhang H, et al. Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiol Biomarkers Prev. 2013;22:251-60 pubmed publisher
    ..64; 95% CI, 0.48-0.85; P, 1.82 × 10(-3)). Associations on 5p15.33 were detected near TERT, the strongest of which was rs2735940 (OR, 0.82; 95% CI, 0.73-0.93; P, 1.1 × 10(-3))...
  65. Rahman R, Latonen L, Wiman K. hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene. 2005;24:1320-7 pubmed
    ..Previously, we found that the human telomerase reverse transcriptase (hTERT) gene is downregulated by p53...
  66. Lebel R, McDuff F, Lavigne P, Grandbois M. Direct visualization of the binding of c-Myc/Max heterodimeric b-HLH-LZ to E-box sequences on the hTERT promoter. Biochemistry. 2007;46:10279-86 pubmed
  67. Tantbirojn P, Triratanachat S, Trivijitsilp P, Niruthisard S. Human telomerase reverse transcriptase (hTERT) expression in borderline ovarian tumors: an immunohistochemical study. J Med Assoc Thai. 2009;92:308-14 pubmed
    To investigate the expression of human telomerase reverse transcriptase (hTERT) in epithelial borderline ovarian tumor (BOT) by immunohistochemistry with correlation to clinicopathologic variables...
  68. Shete S, Hosking F, Robertson L, Dobbins S, Sanson M, Malmer B, et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet. 2009;41:899-904 pubmed publisher
    ..We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7...
  69. Sipos F, Galamb O, Herszenyi L, Molnar B, Solymosi N, Zagoni T, et al. Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis. Scand J Gastroenterol. 2008;43:289-98 pubmed
    ..I-type insulin-like growth factor receptor (IGF1R), hepatocyte growth factor receptor (HGFR), telomerase reverse transcriptase (TERT) and telomerase associated protein (TP-1) expression were evaluated immunohistochemically on ..
  70. Xu J, Wang Y, Geng X, Li Y, Zhang W. Changes of the alternative splicing variants of human telomerase reverse transcriptase during gastric carcinogenesis. Pathobiology. 2009;76:23-9 pubmed publisher
    We attempted to reveal the changes of the human telomerase reverse transcriptase (hTERT) alternative splicing pattern in gastric carcinogenesis. Three alternative splicing sites (alpha, beta, gamma) were selected and designed PCR primer...
  71. Yu S, Chen L, Wang H, Tang X, Fang D, Yang S. hTERT promotes the invasion of telomerase-negative tumor cells in vitro. Int J Oncol. 2009;35:329-36 pubmed
    ..Telomerase-mediated telomere maintenance enables these cells to achieve a fully malignant endpoint, including invasion and metastasis. ..