Gene Symbol: terf
Description: tripartite motif containing 17
Alias: RBCC, RNF16, terf, E3 ubiquitin-protein ligase TRIM17, RING finger protein terf, RING-type E3 ubiquitin transferase TRIM17, ring finger protein 16, testis RING finger protein, tripartite motif-containing protein 17
Species: human
Products:     terf

Top Publications

  1. Lutnicka H, Bojarski B, Witeska M, Tombarkiewicz B, Formicki G. Exposure to herbicide linuron results in alterations in hematological profile and stress biomarkers of common carp (Cyprinus carpio). Ecotoxicology. 2019;28:69-75 pubmed publisher
    ..14 days of exposure and 7, 14 and 30 days of purification and hematological parameters were evaluated: erythrocyte (RBCc) and leukocyte (WBCc) counts, hematocrit (Ht), hemoglobin concentration (Hb), mean cell volume (MCV), mean ..
  2. Bouyain S, Leahy D. Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3. Protein Sci. 2007;16:654-61 pubmed
    ..Nrdp1 belongs to the tripartite or RBCC (RING, B-box, coiled-coil) family of ubiquitin ligases in which the RING domain is responsible for ubiquitin ..
  3. Langevin C, Levraud J, Boudinot P. Fish antiviral tripartite motif (TRIM) proteins. Fish Shellfish Immunol. 2018;86:724-733 pubmed publisher
    Tripartite motif (TRIM) family or RBCC proteins comprises characteristic zinc-binding domains (a RING (R), a B-box type 1 (B1) and a B-box type 2 (B2)) and coiled-coil (CC) domain followed by a C-terminus variable domain...
  4. Xiaoli L, Wujun Z, Jing L. Blocking of tripartite motif 8 protects against lipopolysaccharide (LPS)-induced acute lung injury by regulating AMPKα activity. Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..an N-terminal RING finger, which is followed by two B-boxes and a coiled-coil domain, belonging to the TRIM/RBCC family and playing significant role in meditating inflammation, oxidative stress and apoptosis...
  5. Lassot I, Mora S, Lesage S, Zieba B, Coque E, Condroyer C, et al. The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21. Cell Rep. 2018;25:2484-2496.e9 pubmed publisher
    ..Expression of variants in ZSCAN21 and TRIM41 genes results in the stabilization of the ZSCAN21 protein. Our data thus suggest that deregulation of the TRIM17/TRIM41/ZSCAN21 pathway may be involved in the pathogenesis of PD. ..
  6. Sanchez J, Sparrer K, Chiang C, Reis R, Chiang J, Zurenski M, et al. TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense. J Mol Biol. 2018;430:5280-5293 pubmed publisher
    ..by modulating the multi-domain structure of the TRIM25 dimer, and thereby structural coupling of the SPRY and RBCC elements during the ubiquitination reaction; and by facilitating subcellular localization of the E3 ligase during ..
  7. Zhu J, Mu D, Liu F, Luo M, Luo R, Zheng Y. Activation of NF-?B induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque. Mol Immunol. 2018;101:627-634 pubmed publisher
    ..The Cyclophilin A (CypA) domain plays an important role in omTRIMCyp-mediated NF-?B activation, and RBCC domains have a synergetic effect...
  8. Chen Y, Wright J, Meng X, Leppard K. Promyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment To Activate Interferon Beta and Interferon-Responsive Gene Expression. Mol Cell Biol. 2015;35:1660-72 pubmed publisher
    ..The unique C-terminal domain of PML-II was essential for its activity, while the N-terminal RBCC motif common to all PML isoforms was dispensable...
  9. Lionnard L, Duc P, Brennan M, Kueh A, Pal M, Guardia F, et al. TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1. Cell Death Differ. 2018;: pubmed publisher
    ..Therefore, our data describe a molecular rheostat in which two proteins of the TRIM family antagonistically regulate BCL2A1 stability and modulate cell death. ..

More Information


  1. van Loo E, Mosterd K, Krekels G, Roozeboom M, Ostertag J, Dirksen C, et al. Surgical excision versus Mohs' micrographic surgery for basal cell carcinoma of the face: A randomised clinical trial with 10 year follow-up. Eur J Cancer. 2014;50:3011-20 pubmed publisher
    ..A substantial proportion of recurrences occurred after more than 5years post-treatment: 56% for pBCC and 14% for rBCC. Fewer recurrences occurred after treatment of high risk facial BCC with MMS compared to treatment with SE...
  2. Chen Z, Wang Z, Guo W, Zhang Z, Zhao F, Zhao Y, et al. TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma. Oncogene. 2015;34:3946-56 pubmed publisher
    Tripartite motif-containing protein 35 (TRIM35) is a member of RBCC family, which has a highly conserved order consisting of a RING domain followed by one or two B-Box domains and then a coiled-coil domain...
  3. Zhang X, Zhao H, Chen Y, Luo H, Yao B. Molecular characterization of a CpTRIM35-like protein and its splice variants from whitespotted bamboo shark (Chiloscyllium plagiosum). Biochem Biophys Res Commun. 2014;453:425-31 pubmed publisher
    ..Deduced CpTRIM35 has a RBCC-PRY/SPRY structure typical of TRIM proteins, and its splice variants (CpTRIM35-1-3) have different truncations at ..
  4. Mourão J, Novais C, Machado J, Peixe L, Antunes P. Metal tolerance in emerging clinically relevant multidrug-resistant Salmonella enterica serotype 4,[5],12:i:- clones circulating in Europe. Int J Antimicrob Agents. 2015;45:610-6 pubmed publisher
    ..Screening for copper (pcoA-pcoD/tcrB), silver/copper (silA-silE), mercury (merA), arsenic (arsB) and tellurite (terF) tolerance genes was performed by PCR/sequencing...
  5. Zhang X, Zhao H, Chen Y, Luo H, Yang P, Yao B. A zebrafish (Danio rerio) bloodthirsty member 20 with E3 ubiquitin ligase activity involved in immune response against bacterial infection. Biochem Biophys Res Commun. 2015;457:83-9 pubmed publisher
    ..Deduced btr20 represents a RBCC-B30.2 TRIM protein containing 544 amino acids...
  6. Lassot I, Robbins I, Kristiansen M, Rahmeh R, Jaudon F, Magiera M, et al. Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis. Cell Death Differ. 2010;17:1928-41 pubmed publisher
    ..In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical E3 ubiquitin ligases involved in the control of neuronal apoptosis upstream ..
  7. Tan H, Qi J, Chu G, Liu Z. Tripartite Motif 16 Inhibits the Migration and Invasion in Ovarian Cancer Cells. Oncol Res. 2017;25:551-558 pubmed publisher
    Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite motif (TRIM) protein family, has been shown to play a role in tumor development and progression...
  8. Zhao P, Guan H, Dai Z, Ma Y, Liu X, Wang X. Knockdown of Tripartite Motif-Containing Protein 37 (TRIM37) Inhibits the Proliferation and Tumorigenesis in Colorectal Cancer Cells. Oncol Res. 2017;25:115-122 pubmed publisher
    Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers...
  9. Lee A, Cingoz O, Sabo Y, Goff S. Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus. Virology. 2018;516:165-175 pubmed publisher
    ..The RBCC domain of Trim28 was sufficient for interaction with YY1, and acidic region 1 and zinc fingers of YY1 were ..
  10. Song K, Choi C, Lee H, Oh S, Woo S, Hong S, et al. HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells. Cancer Res. 2017;77:5039-5053 pubmed publisher
    ..i>Cancer Res; 77(18); 5039-53. ©2017 AACR. ..
  11. Pfirrmann T, Jandt E, Ranft S, Lokapally A, Neuhaus H, Perron M, et al. Hedgehog-dependent E3-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development. Proc Natl Acad Sci U S A. 2016;113:10103-8 pubmed publisher
    ..Here, we report that Mid1, a member of the RBCC/TRIM E3 ligase family, which was first identified in patients with the X-chromosome-linked Opitz BBB/G (OS) ..
  12. Pizarro F, Olivares M, Valenzuela C, Brito A, Weinborn V, Flores S, et al. The effect of proteins from animal source foods on heme iron bioavailability in humans. Food Chem. 2016;196:733-8 pubmed publisher
    ..Study 1 was focused on heme, red blood cell concentrate (RBCC), hemoglobin (Hb), RBCC+beef meat; study 2 on heme, heme+fish, chicken, and beef; and study 3 on heme and heme+..
  13. Flowers S, Beyer K, Perez M, Jeffe D. Early Environmental Field Research Career Exploration: An Analysis of Impacts on Precollege Apprentices. CBE Life Sci Educ. 2016;15: pubmed
    ..training with research assistance opportunities, and the subsequent Tyson Environmental Research Fellowships (TERF) program provides immersive internships on university field station-based research teams...
  14. Mélo S, Diniz A, de Lira V, de Oliveira Muniz S, da Silva G, Manso H, et al. Antioxidant and haematological biomarkers in different groups of horses supplemented with polyunsaturated oil and vitamin E. J Anim Physiol Anim Nutr (Berl). 2016;100:852-9 pubmed publisher
    ..three time periods (pretest, after 4 weeks and after 8 weeks) to analyse the following: the red blood cell count (RBCc); haemoglobin (Hb); haematocrit (HT); leucocytes; lymphocytes; platelets; the mean corpuscular volume (MCV); the ..
  15. Mourão J, Marçal S, Ramos P, Campos J, Machado J, Peixe L, et al. Tolerance to multiple metal stressors in emerging non-typhoidal MDR Salmonella serotypes: a relevant role for copper in anaerobic conditions. J Antimicrob Chemother. 2016;71:2147-57 pubmed publisher
    ..These genes were frequently co-located with merA?±?terF and/or antibiotic resistance genes in plasmids (100-270 kb; IncHI2/IncHI1/IncN/IncFIIA; mostly transferable by ..
  16. Ding D, Bergmaier P, Sachs P, Klangwart M, Rückert T, Bartels N, et al. The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes. J Biol Chem. 2018;293:2711-2724 pubmed publisher
    ..We also found that the RING B-box coiled-coil (RBCC) domain in KAP1 and the proximal coupling of ubiquitin conjugation to ER degradation (CUE) domain in SMARCAD1 ..
  17. Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, et al. Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget. 2016;7:34688-702 pubmed publisher
    ..that CHK1 inhibitor AZD7762 alone significantly inhibited the growth of radioresistant breast cancer cells (RBCC)...
  18. Li L, Dong L, Qu X, Jin S, Lv X, Tan G. Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion. Int J Oncol. 2016;48:1639-49 pubmed publisher
    Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has been demonstrated to have significant effects on tumor migration by previous studies, but its specific contribution to ..
  19. Tomar D, Prajapati P, Lavie J, Singh K, Lakshmi S, Bhatelia K, et al. TRIM4; a novel mitochondrial interacting RING E3 ligase, sensitizes the cells to hydrogen peroxide (H2O2) induced cell death. Free Radic Biol Med. 2015;89:1036-48 pubmed publisher
    ..In current study, we studied the role of TRIM4, a member of the TRIM/RBCC protein family of RING E3 ligase, in regulation of hydrogen peroxide (H2O2) induced cell death...
  20. Stampella A, Di Marco S, Pirri D, de la Torre X, Botrè F, Donati F. Application of DNA-based forensic analysis for the detection of homologous transfusion of whole blood and of red blood cell concentrates in doping control. Forensic Sci Int. 2016;265:204-10 pubmed publisher
    ..white blood cells, the same procedure resulted effective also in detecting mixtures of red blood cell concentrates (RBCC) from leukodepletion procedure: DNA of the donor from the residual white blood cells resulted still detectable, ..
  21. Wallenhammar A, Anandapadamanaban M, Lemak A, Mirabello C, Lundström P, Wallner B, et al. Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain. PLoS ONE. 2017;12:e0181551 pubmed publisher
    ..motif-containing (TRIM) proteins are defined by the sequential arrangement of RING, B-box and coiled-coil domains (RBCC), where the B-box domain is a unique feature of the TRIM protein family...
  22. Ogawa S, Goto W, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, et al. Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. Biochem Biophys Res Commun. 1998;251:515-9 pubmed
    ..This gene was designated testis RING finger protein (terf) because the corresponding transcripts were detected almost exclusively in the testis by Northern ..
  23. Mandell M, Jain A, Arko Mensah J, Chauhan S, Kimura T, Dinkins C, et al. TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev Cell. 2014;30:394-409 pubmed publisher
    ..Thus, our study establishes that TRIMs can function both as regulators of autophagy and as autophagic cargo receptors, and reveals a basis for selective autophagy in mammalian cells. ..
  24. Aurino S, Piluso G, Saccone V, Cacciottolo M, D Amico F, Dionisi M, et al. Candidate-gene testing for orphan limb-girdle muscular dystrophies. Acta Myol. 2008;27:90-7 pubmed
    ..We identified a large number of variations in any of the genes in both patients and controls. Correlations with disease or possible modifying effects on the LGMD phenotype remain to be investigated. ..
  25. Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd M, Kimura T, et al. TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Dev Cell. 2016;39:13-27 pubmed publisher
    ..The cooperation between TRIM16 and Galectin-3 in targeting and activation of selective autophagy protects cells from lysosomal damage and Mycobacterium tuberculosis invasion. ..
  26. Rishi A, Hui Huang S, O Sullivan B, Goldstein D, Lu L, Ringash J, et al. Outcome following radiotherapy for head and neck basal cell carcinoma with 'aggressive' features. Oral Oncol. 2017;72:157-164 pubmed publisher
    ..HN-BCC patients were identified, including 38 (35%) presenting de novo and 70 (65%) treated for recurrence (rBCC). dRT was offered to 72 (66.7%) patients and PORT to 36 (33.3%). Median follow-up was 3.5years...
  27. Mojsa B, Mora S, Bossowski J, Lassot I, Desagher S. Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17. Cell Death Differ. 2015;22:274-86 pubmed publisher
  28. Endo H, Ikeda K, Urano T, Horie Inoue K, Inoue S. Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation. J Biochem. 2012;151:139-44 pubmed publisher
    b>Terf/TRIM17 is a tripartite motif protein that has been originally isolated from testis. Terf has been characterized to exhibit an E3 ubiquitin ligase activity and to undergo self-ubiquitination...
  29. Ogawa S, Saito T, Matsuda Y, Seki N, Hayashi A, Orimo A, et al. Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Cytogenet Cell Genet. 2000;89:56-8 pubmed
    RNF16 (ring finger protein 16; alias terf), a member of the RING finger family, has been shown to be exclusively expressed in the testis...
  30. Urano T, Usui T, Takeda S, Ikeda K, Okada A, Ishida Y, et al. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. Biochem Biophys Res Commun. 2009;383:263-8 pubmed publisher
    b>Terf/TRIM17 is a member of the TRIM family of proteins, which is characterized by the RING finger, B-box, and coiled-coil domains. In the present study, we found that terf interacts with TRIM44...
  31. Mandell M, Jain A, Kumar S, Castleman M, Anwar T, Eskelinen E, et al. TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. J Cell Sci. 2016;129:3562-3573 pubmed
    ..This study further expands the roles of TRIMs in regulating selective autophagy by showing that a single TRIM can, depending upon a target, either positively or negatively regulate autophagy. ..