TERC

Summary

Gene Symbol: TERC
Description: telomerase RNA component
Alias: DKCA1, PFBMFT2, SCARNA19, TRC3, hTR
Species: human
Products:     TERC

Top Publications

  1. Feng J, Funk W, Wang S, Weinrich S, Avilion A, Chiu C, et al. The RNA component of human telomerase. Science. 1995;269:1236-41 pubmed
    ..Here, the cloning of the RNA component of human telomerase, termed hTR, is described...
  2. Collins K. Physiological assembly and activity of human telomerase complexes. Mech Ageing Dev. 2008;129:91-8 pubmed
    ..This review describes the current understanding of telomerase in humans, with particular focus on telomerase biogenesis and regulation in its cellular context. ..
  3. Sauerwald A, Sandin S, Cristofari G, Scheres S, Lingner J, Rhodes D. Structure of active dimeric human telomerase. Nat Struct Mol Biol. 2013;20:454-60 pubmed publisher
  4. Theimer C, Jady B, Chim N, Richard P, Breece K, Kiss T, et al. Structural and functional characterization of human telomerase RNA processing and cajal body localization signals. Mol Cell. 2007;27:869-81 pubmed
    The RNA component of human telomerase (hTR) includes H/ACA and CR7 domains required for 3' end processing, localization, and accumulation...
  5. Qiao F, Cech T. Triple-helix structure in telomerase RNA contributes to catalysis. Nat Struct Mol Biol. 2008;15:634-40 pubmed publisher
    ..The role of RNA in telomerase catalysis may have been acquired relatively recently or, alternatively, telomerase may be a molecular fossil representing an evolutionary link between RNA enzymes and RNP enzymes. ..
  6. DU H, Pumbo E, Ivanovich J, An P, Maziarz R, Reiss U, et al. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. Blood. 2009;113:309-16 pubmed publisher
    ..is a rare inherited form of bone marrow failure (BMF) caused by mutations in telomere maintaining genes including TERC and TERT...
  7. Atzmon G, Cho M, Cawthon R, Budagov T, Katz M, Yang X, et al. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A. 2010;107 Suppl 1:1710-7 pubmed publisher
    ..Thus, variations in human telomerase gene that are associated with better maintenance of telomere length may confer healthy aging and exceptional longevity in humans. ..
  8. Yamaguchi H, Baerlocher G, Lansdorp P, Chanock S, Nunez O, Sloand E, et al. Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood. 2003;102:916-8 pubmed
    Mutations in the human telomerase RNA (TERC) occur in autosomal dominant dyskeratosis congenita (DKC)...
  9. Levy D, Neuhausen S, Hunt S, Kimura M, Hwang S, Chen W, et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A. 2010;107:9293-8 pubmed publisher
    ..In addition, we confirmed the telomerase RNA component (TERC) as a gene associated with LTL (P = 1.1 x 10(-5))...

More Information

Publications80

  1. Chen J, Greider C. Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. EMBO J. 2003;22:304-14 pubmed
    ..These experiments identify essential residues of the telomerase RNA that regulate telomerase activity and processivity. ..
  2. Vulliamy T, Marrone A, Knight S, Walne A, Mason P, Dokal I. Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation. Blood. 2006;107:2680-5 pubmed
    ..In reviewing the mutation profile that is found in DC, we describe 9 novel mutations in the DKC1 gene and 3 novel TERC mutations responsible for the X-linked and autosomal dominant forms of the disease, respectively, but find that two ..
  3. Cronkhite J, Xing C, Raghu G, Chin K, Torres F, Rosenblatt R, et al. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med. 2008;178:729-37 pubmed publisher
    Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres...
  4. Heselmeyer Haddad K, Sommerfeld K, White N, Chaudhri N, Morrison L, Palanisamy N, et al. Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer. Am J Pathol. 2005;166:1229-38 pubmed
    ..almost invariably carry extra copies of chromosome arm 3q, resulting in a gain of the human telomerase gene (TERC)...
  5. Theimer C, Blois C, Feigon J. Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function. Mol Cell. 2005;17:671-82 pubmed
    Human telomerase contains a 451 nt RNA (hTR) and several proteins, including a specialized reverse transcriptase (hTERT)...
  6. Andersson S, Sowjanya P, Wangsa D, Hjerpe A, Johansson B, Auer G, et al. Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears. Am J Pathol. 2009;175:1831-47 pubmed publisher
    ..harbor additional copies of the chromosome arm 3q, resulting in genomic amplification of the human telomerase gene TERC. Here, we evaluated TERC amplification in routinely collected liquid based cytology (LBC) samples with ..
  7. Codd V, Mangino M, van der Harst P, Braund P, Kaiser M, Beveridge A, et al. Common variants near TERC are associated with mean telomere length. Nat Genet. 2010;42:197-9 pubmed publisher
    ..72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component...
  8. Sexton A, Collins K. The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation. Mol Cell Biol. 2011;31:736-43 pubmed publisher
    ..Here, we describe a motif of human telomerase RNA (hTR), not previously characterized in a cellular context, comprised of several guanosine tracts near the RNA 5' end...
  9. Chen J, Greider C. Functional analysis of the pseudoknot structure in human telomerase RNA. Proc Natl Acad Sci U S A. 2005;102:8080-5; discussion 8077-9 pubmed
    ..The mutational analysis further suggests that telomerase RNA can function independent of the proposed intermolecular pairings between pseudoknot regions on two RNA molecules. ..
  10. Mangino M, Hwang S, Spector T, Hunt S, Kimura M, Fitzpatrick A, et al. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet. 2012;21:5385-94 pubmed publisher
    ..Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated with the inter-individual LTL variation...
  11. Kedde M, le Sage C, Duursma A, Zlotorynski E, van Leeuwen B, Nijkamp W, et al. Telomerase-independent regulation of ATR by human telomerase RNA. J Biol Chem. 2006;281:40503-14 pubmed
    The human telomerase RNA (hTR), together with the telomerase reverse transcriptase, hTERT, constitute the core components of telomerase that is essential for telomere maintenance...
  12. Fu D, Collins K. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell. 2007;28:773-85 pubmed
  13. Zee R, Ridker P, Chasman D. Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study. Clin Chim Acta. 2011;412:199-202 pubmed publisher
    ..of 11 telomere-associated candidate genes (TERT, POT1, TNKS, TERF1, TNKS2, UCP2, TEP1, ACD, TERF2, TERF2IP, and TERC) were investigated in 23,294 Caucasian participants of the Women's Genome Health Study...
  14. Venteicher A, Meng Z, Mason P, Veenstra T, Artandi S. Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell. 2008;132:945-57 pubmed publisher
    ..have been identified thus far: the telomerase reverse transcriptase (TERT), the telomerase RNA component (TERC), and the TERC-binding protein dyskerin...
  15. Jones A, Beggs A, Carvajal Carmona L, Farrington S, Tenesa A, Walker M, et al. TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut. 2012;61:248-54 pubmed publisher
    ..Carriers of the common allele at SNP rs10936599, near the telomerase RNA component (TERC) locus, had significantly longer telomeres...
  16. Mitchell J, Collins K. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol Cell. 2000;6:361-71 pubmed
    ..Here, we elucidate structural requirements for function of the essential RNA component of human telomerase, hTR. Two motifs within the independently stable H/ACA domain of hTR are required for accumulation of the mature RNA in ..
  17. Chen J, Blasco M, Greider C. Secondary structure of vertebrate telomerase RNA. Cell. 2000;100:503-14 pubmed
    ..The proposed vertebrate telomerase RNA structure displays a strikingly similar topology to the previously determined ciliate telomerase RNA structure, implying an evolutionary conservation of the global architecture of telomerase RNA. ..
  18. Kim N, Zhang Q, Zhou J, Theimer C, Peterson R, Feigon J. Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA. J Mol Biol. 2008;384:1249-61 pubmed publisher
    ..The bulge U may serve as a hinge providing backbone flexibility in this region. ..
  19. Egan E, Collins K. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol Cell Biol. 2010;30:2775-86 pubmed publisher
    The H/ACA motif of human telomerase RNA (hTR) directs specific pathways of endogenous telomerase holoenzyme assembly, function, and regulation...
  20. Shen Q, Zhang Z, Yu L, Cao L, Zhou D, Kan M, et al. Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population. Eur J Hum Genet. 2011;19:721-3 pubmed publisher
    ..study has identified an association between leukocyte telomere length (LTL) and a locus at 3q26 that includes TERC. In order to evaluate the effects of the SNPs rs12696304 and rs16847897 near TERC in the population of mainland ..
  21. Calado R, Regal J, Hills M, Yewdell W, Dalmazzo L, Zago M, et al. Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A. 2009;106:1187-92 pubmed publisher
    ..samples from 133 consecutive patients with acute myeloid leukemia and 198 controls for variations in TERT and TERC genes...
  22. Cristofari G, Adolf E, Reichenbach P, Sikora K, Terns R, Terns M, et al. Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation. Mol Cell. 2007;27:882-9 pubmed
    ..Recently, the telomerase RNA subunit (hTR) was shown to accumulate in Cajal bodies (CBs), subnuclear structures implicated in ribonucleoprotein maturation...
  23. Weinrich S, Pruzan R, Ma L, Ouellette M, Tesmer V, Holt S, et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet. 1997;17:498-502 pubmed
    ..In addition to the human telomerase RNA component (hTR; ref...
  24. Cohen S, Graham M, Lovrecz G, Bache N, Robinson P, Reddel R. Protein composition of catalytically active human telomerase from immortal cells. Science. 2007;315:1850-3 pubmed
    ..Mass spectrometric sequencing of the protein components and molecular size determination indicated an enzyme composition of two molecules each of telomerase reverse transcriptase, telomerase RNA, and dyskerin. ..
  25. Goldman F, Bouarich R, Kulkarni S, Freeman S, DU H, Harrington L, et al. The effect of TERC haploinsufficiency on the inheritance of telomere length. Proc Natl Acad Sci U S A. 2005;102:17119-24 pubmed
    ..dominant dyskeratosis congenita (AD DC), a rare inherited bone marrow failure syndrome, is caused by mutations in TERC, the RNA component of telomerase...
  26. Ting N, Yu Y, Pohorelic B, Lees Miller S, Beattie T. Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase. Nucleic Acids Res. 2005;33:2090-8 pubmed
    ..Although there is no sequence similarity between TLC1 and the RNA component (hTR) of human telomerase, we show that human Ku70/80 interacts with hTR both in vitro and in a cellular context...
  27. Mitchell J, Wood E, Collins K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature. 1999;402:551-5 pubmed
    ..The pathology of DKC is consistent with compromised telomerase function leading to a defect in telomere maintenance, which may limit the proliferative capacity of human somatic cells in epithelia and blood. ..
  28. Vulliamy T, Marrone A, Szydlo R, Walne A, Mason P, Dokal I. Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC. Nat Genet. 2004;36:447-9 pubmed
    ..Here we show that disease anticipation is observed in families with this disease and that this is associated with progressive telomere shortening. ..
  29. Ly H, Blackburn E, Parslow T. Comprehensive structure-function analysis of the core domain of human telomerase RNA. Mol Cell Biol. 2003;23:6849-56 pubmed
    ..Additionally, we provide evidence that naturally occurring hTER sequence polymorphisms found in some patients with aplastic anemia can inhibit telomerase activity by disrupting critical structures within the hTER core domain. ..
  30. Ohtsuka T, Yamakage A, Yamazaki S. The polymorphism of telomerase RNA component gene in patients with systemic sclerosis. Br J Dermatol. 2002;147:250-4 pubmed
    ..01) and G/G plus G/A (81.1% and 94.9%, respectively; P < 0.01). These results showed the possible involvement of a telomerase abnormality in the emergence of abnormal fibroblast clones in SSc skin-derived fibroblasts. ..
  31. Zhao J, Bilsland A, Hoare S, Keith W. Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene. FEBS Lett. 2003;536:111-9 pubmed
    The proximal promoter of the telomerase RNA gene, hTR, contains four Sp1 sites and one CCAAT box. We have carried out a functional analysis of the role of these sequence elements...
  32. Prescott J, Kraft P, Chasman D, Savage S, Mirabello L, Berndt S, et al. Genome-wide association study of relative telomere length. PLoS ONE. 2011;6:e19635 pubmed publisher
    ..the inverse association of log relative telomere length with the minor allele variant [C] of rs16847897 at the TERC locus (per allele ??=?-0.03, P?=?0.003) identified by a previous genome-wide association study...
  33. Codd V, Nelson C, Albrecht E, Mangino M, Deelen J, Buxton J, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013;45:422-7, 427e1-2 pubmed publisher
    ..Five of the loci contain candidate genes (TERC, TERT, NAF1, OBFC1 and RTEL1) that are known to be involved in telomere biology...
  34. Marrone A, Sokhal P, Walne A, Beswick R, Kirwan M, Killick S, et al. Functional characterization of novel telomerase RNA (TERC) mutations in patients with diverse clinical and pathological presentations. Haematologica. 2007;92:1013-20 pubmed
    Functional characterization of heterozygous TERC (telomerase RNA component) and TERT (telomerase reverse transcriptase) mutations found in autosomal dominant dyskeratosis congenita (DC) and aplastic anemia (AA) shows that telomerase ..
  35. Vulliamy T, Marrone A, Dokal I, Mason P. Association between aplastic anaemia and mutations in telomerase RNA. Lancet. 2002;359:2168-70 pubmed
    ..Germline mutations in the gene encoding the RNA component of telomerase (hTR) have been seen in the autosomal dominant form of dyskeratosis congenita--an inherited syndrome characterised by ..
  36. Mezzasoma L, Antognelli C, Del Buono C, Stracci F, Cottini E, Cochetti G, et al. Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer. BMC Urol. 2010;10:17 pubmed publisher
    ..Aim of this study is to investigate the role of human telomerase RNA (hTR), human telomerase reverse transcriptase (hTERT) and CDC28 protein kinase regulatory subunit 2 (CKS2) in bladder ..
  37. Mefford M, Zappulla D. Physical Connectivity Mapping by Circular Permutation of Human Telomerase RNA Reveals New Regions Critical for Activity and Processivity. Mol Cell Biol. 2016;36:251-61 pubmed publisher
    ..The telomerase enzyme minimally requires an RNA (hTR) and a specialized reverse transcriptase protein (TERT) for activity in vitro...
  38. Trahan C, Dragon F. Dyskeratosis congenita mutations in the H/ACA domain of human telomerase RNA affect its assembly into a pre-RNP. RNA. 2009;15:235-43 pubmed publisher
    ..Like all H/ACA RNAs, the H/ACA domain of nascent human telomerase RNA (hTR) forms a pre-RNP with H/ACA proteins NAF1, dyskerin, NOP10, and NHP2 in vivo...
  39. Jung S, Park N, Shin J, Park B, Kim C, Lee J, et al. Prognostic impact of telomere maintenance gene polymorphisms on hepatocellular carcinoma patients with chronic hepatitis B. Hepatology. 2014;59:1912-20 pubmed publisher
    ..026). These observations suggest that the SNPs of telomere maintenance genes play a potential role in the development of HCC and the survival of HCC patients with chronic HBV infections. ..
  40. Xin Z, Beauchamp A, Calado R, Bradford J, Regal J, Shenoy A, et al. Functional characterization of natural telomerase mutations found in patients with hematologic disorders. Blood. 2007;109:524-32 pubmed
    ..Inherited telomerase gene mutations, therefore, operate by various mechanisms to shorten telomere lengths, leading to limited marrow stem cell reserve and renewal capacity in patients with hematologic disorders. ..
  41. Serakinci N, Hoare S, Kassem M, Atkinson S, Keith W. Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell. Regen Med. 2006;1:125-31 pubmed
    ..b>hTR expression is also increased in TSA-treated hMSCs, concomitant with changes in Pol II and TFIIB dynamics.
  42. Biron Shental T, Kitay Cohen Y, Tene T, Sharony R, Amiel A. Increased TERC gene copy number in amniocytes from fetuses with trisomy 18 or a sex chromosome aneuploidy. Gene. 2012;506:46-9 pubmed publisher
    ..lengthens telomeres and has enhanced expression in numerous malignancies; one of its components is encoded by the TERC gene...
  43. Nicholls C, Pinto A, Li H, Li L, Wang L, Simpson R, et al. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component. Proc Natl Acad Sci U S A. 2012;109:13308-13 pubmed publisher
    ..We report here that GAPDH interacts with the telomerase RNA component (TERC), inhibits telomerase activity, and induces telomere shortening and breast cancer cell senescence...
  44. Zheng X, Liang P, Zheng Y, Yi P, Liu Q, Han J, et al. Clinical significance of hTERC gene detection in exfoliated cervical epithelial cells for cervical lesions. Int J Gynecol Cancer. 2013;23:785-90 pubmed publisher
    ..89%, and the specificity was 93.75%. Detection of abnormal amplification of the hTERC gene can assist in screening cervical lesions and identifying CIN I/II patients with a high progression risk. ..
  45. Sukenik Halevy R, Amiel A, Kidron D, Liberman M, Ganor Paz Y, Biron Shental T. Telomere homeostasis in trophoblasts and in cord blood cells from pregnancies complicated with preeclampsia. Am J Obstet Gynecol. 2016;214:283.e1-283.e7 pubmed publisher
    ..The TERC gene encodes the RNA template of the telomerase...
  46. Wang D, Hu E, Wu P, Yuan W, Xu S, Sun Z, et al. Genetic variant near TERC influencing the risk of gliomas with older age at diagnosis in a Chinese population. J Neurooncol. 2015;124:57-64 pubmed publisher
    A recent genome-wide association study has identified an association between rs1920116 near TERC and high-grade glioma in populations of European ancestry...
  47. Tu Z, Zhang A, Wu R, Jiang J, Li Y, Wulan N, et al. Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders. Cancer Genet Cytogenet. 2009;191:10-6 pubmed publisher
    To evaluate genomic amplification of the human telomerase RNA gene (TERC) as a supportive approach to cytopathology or histopathology in diagnosis of low-grade and high-grade uterine cervical lesions, 1,033 Chinese women at three medical ..
  48. Borie R, Tabèze L, Thabut G, Nunes H, Cottin V, Marchand Adam S, et al. Prevalence and characteristics of TERT and TERC mutations in suspected genetic pulmonary fibrosis. Eur Respir J. 2016;48:1721-1731 pubmed publisher
    Telomerase reverse transcriptase (TERT) or telomerase RNA (TERC) gene mutation is a major monogenic cause of pulmonary fibrosis. Sequencing of TERT/TERC genes is proposed to patients with familial pulmonary fibrosis...
  49. Li Y, Wulan N, Liu Z, Li J, Wang C, Zhou Y, et al. [Amplification and clinical significance of hTERC gene in the cervical exfoliated cells from natural population in Shenzhen]. Zhonghua Liu Xing Bing Xue Za Zhi. 2009;30:946-50 pubmed
    ..The evidence of hTERC, with or without amplification, might serve as a prognostic indicator to measure the grade of lesion. ..
  50. Calado R, Pintão M, Rocha V, Falcão R, Bitencourt M, Silva W, et al. Lack of mutations in the human telomerase RNA component (hTERC) gene in Fanconi's anemia. Haematologica. 2004;89:1012-3 pubmed
    ..Only one patient was heterozygous for the G58A polymorphism. No other mutation or deletion was found. We conclude that hTERC gene mutations do not contribute to telomere shortening in FA. ..
  51. Theimer C, Finger L, Trantirek L, Feigon J. Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA. Proc Natl Acad Sci U S A. 2003;100:449-54 pubmed
  52. Walbott H, Machado Pinilla R, Liger D, Blaud M, Rety S, Grozdanov P, et al. The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. Genes Dev. 2011;25:2398-408 pubmed publisher
    ..We propose that Shq1p operates as a Cbf5p chaperone during RNP assembly by acting as an RNA placeholder, thereby preventing Cbf5p from nonspecific RNA binding before association with an H/ACA RNA and the other core RNP proteins. ..
  53. Al Khaldi R, Mojiminiyi O, AlMulla F, Abdella N. Associations of TERC Single Nucleotide Polymorphisms with Human Leukocyte Telomere Length and the Risk of Type 2 Diabetes Mellitus. PLoS ONE. 2015;10:e0145721 pubmed publisher
    ..were reported for SNP rs12696304 and rs16847897 near the non-coding Ribose Nucleic Acid (RNA) molecule component (TERC) of telomerase enzyme on 3q26...
  54. Shukla S, Schmidt J, Goldfarb K, Cech T, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nat Struct Mol Biol. 2016;23:286-92 pubmed publisher
    Mutations in the human telomerase RNA component (hTR), the telomerase ribonucleoprotein component dyskerin (DKC1) and the poly(A) RNase (PARN) can lead to reduced levels of hTR and to dyskeratosis congenita (DC)...
  55. de Lange T, Jacks T. For better or worse? Telomerase inhibition and cancer. Cell. 1999;98:273-5 pubmed
  56. Wang Y, Yesselman J, Zhang Q, Kang M, Feigon J. Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human. Proc Natl Acad Sci U S A. 2016;113:E5125-34 pubmed publisher
    ..The organization of the t/PK on telomerase reverse transcriptase for medaka and human is modeled based on the cryoEM structure of Tetrahymena telomerase, providing insight into function. ..
  57. Pooley K, Bojesen S, Weischer M, Nielsen S, Thompson D, Amin Al Olama A, et al. A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet. 2013;22:5056-64 pubmed publisher
    ..2 (BCL2L1). We additionally confirmed (Ptrend < 5 × 10(-14)) the previously reported loci at 3q26.2 (TERC), 5p15.3 (TERT) and 10q24...
  58. Glasspool R, Burns S, Hoare S, Svensson C, Keith W. The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes. Neoplasia. 2005;7:614-22 pubmed
    ..CtBP can be found within a histone-modifying complex and it is possible that a CtBP complex, associating with the SP1 sites, represses transcription from the telomerase promoters by modifying chromatin structure. ..
  59. Martadinata H, Phan A. Formation of a stacked dimeric G-quadruplex containing bulges by the 5'-terminal region of human telomerase RNA (hTERC). Biochemistry. 2014;53:1595-600 pubmed publisher
    ..investigate the structure formed by the first 18-nt of the 5'-terminal region of the human telomerase RNA (hTERC or hTR) using gel electrophoresis and UV, CD, and NMR spectroscopy...
  60. Penzo M, Ludovini V, Treré D, Siggillino A, Vannucci J, Bellezza G, et al. Dyskerin and TERC expression may condition survival in lung cancer patients. Oncotarget. 2015;6:21755-60 pubmed
    ..modification of uridine on ribosomal and small nuclear RNAs and the stabilization of the telomerase RNA component (TERC). In human tumors dyskerin expression was found to be associated with both rRNA modification and TERC levels...
  61. Pruzan R, Pongracz K, Gietzen K, Wallweber G, Gryaznov S. Allosteric inhibitors of telomerase: oligonucleotide N3'-->P5' phosphoramidates. Nucleic Acids Res. 2002;30:559-68 pubmed
    ..N3'-->P5' phosphoramidates (NPs) we have identified a region of the human telomerase RNA subunit (hTR) approximately 100 nt downstream from the template region whose structural integrity appears crucial for telomerase ..
  62. Visnovsky J, Kudela E, Farkasova A, Balharek T, Krkoska M, Danko J. Amplification of TERT and TERC genes in cervical intraepithelial neoplasia and cervical cancer. Neuro Endocrinol Lett. 2014;35:518-22 pubmed
    ..In our study we focused on the analysis of the amplification patterns of telomerase genes TERT and TERC. We included 39 patients in our study between January 2012 and April 2013...
  63. Wang X, Liu J, Xi H, Cai L. The significant diagnostic value of human telomerase RNA component (hTERC) gene detection in high-grade cervical lesions and invasive cancer. Tumour Biol. 2014;35:6893-900 pubmed publisher
    ..84). The DOR estimate was performed, and the result was 17.37. Our meta-analysis showed that the detection of genomic amplification of hTERC is a noninvasive and effective approach for high-grade cervical lesions and invasive cancer. ..
  64. Figueroa J, Ye Y, Siddiq A, Garcia Closas M, Chatterjee N, Prokunina Olsson L, et al. Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet. 2014;23:1387-98 pubmed publisher
  65. Zhou J, Zhang H, Chen Q, Han D, Pei F, Zhang L, et al. Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma. World J Gastroenterol. 2003;9:1808-14 pubmed
    ..the relationship between telomerase activity and its subunit expression and the inhibitory effect of antisense hTR on pancreatic carcinogenesis...
  66. Wisman G, Hollema H, Helder M, Knol A, Van der Meer G, Krans M, et al. Telomerase in relation to expression of p53, c-Myc and estrogen receptor in ovarian tumours. Int J Oncol. 2003;23:1451-9 pubmed
    ..In conclusion, these data suggest that p53 expression (e.g. p53 mutation) as well as c-Myc expression may have a role in regulation of telomerase activity in ovarian tumours. ..
  67. Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, et al. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature. 2009;461:230-5 pubmed publisher
    ..These observations identify a mammalian RdRP composed of TERT in complex with RMRP. ..
  68. Nakamura A, Suda T, Honma T, Takahashi T, Igarashi M, Waguri N, et al. Increased hTR expression during transition from adenoma to carcinoma is not associated with promoter methylation. Dig Dis Sci. 2004;49:1504-12 pubmed
    Human telomerase RNA component (hTR) expression, which increases in the majority of cancer cells with an acquisition of telomerase activity, was concomitantly evaluated with methylation status and human telomerase reverse transcriptase (..
  69. Chen G, Wen J, Tinoco I. Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA. RNA. 2007;13:2175-88 pubmed
    ..Possible nonnative structures and folding pathways are discussed. ..
  70. Baena Del Valle J, Zheng Q, Esopi D, Rubenstein M, Hubbard G, Moncaliano M, et al. MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer. J Pathol. 2018;244:11-24 pubmed publisher
    Telomerase consists of at least two essential elements, an RNA component hTR or TERC that contains the template for telomere DNA addition and a catalytic reverse transcriptase (TERT)...