TEPP

Summary

Gene Symbol: TEPP
Description: testis, prostate and placenta expressed
Alias: testis, prostate and placenta-expressed protein, testicular tissue protein Li 196, testis/prostate/placenta-expressed protein
Species: human
Products:     TEPP

Top Publications

  1. Qiao H, He X, Zhang Q, Yuan H, Wang D, Li L, et al. Alpha-synuclein induces microglial migration via PKM2-dependent glycolysis. Int J Biol Macromol. 2019;129:601-607 pubmed publisher
    ..Additionally, the PKM2 activator TEPP-46 promoted migration ability in a-synuclein-treated microglia, compared to treatment with a-synuclein alone...
  2. Saleme B, Gurtu V, Zhang Y, Kinnaird A, Boukouris A, Gopal K, et al. Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity. Sci Transl Med. 2019;11: pubmed publisher
    ..Treatment with TEPP-46 (a compound that stabilizes tetrameric PKM2) suppressed doxorubicin-induced cardiomyocyte apoptosis, preventing ..
  3. Tee S, Park J, Hurd R, Brimacombe K, Boxer M, Massoud T, et al. PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose. Oncotarget. 2017;8:90959-90968 pubmed publisher
    ..We demonstrate that TEPP-46, a PKM2 activator, results in increased glucose consumption, providing the rationale for combining PKM2 ..
  4. Witney T, James M, Shen B, Chang E, Pohling C, Arksey N, et al. PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2. Sci Transl Med. 2015;7:310ra169 pubmed publisher
    ..In addition, systemic treatment of mice with the PKM2 activator TEPP-46 resulted in complete abrogation of the PET signal in intracranial GBM39 tumors...
  5. Palsson McDermott E, Dyck L, Zasłona Z, Menon D, McGettrick A, Mills K, et al. Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors. Front Immunol. 2017;8:1300 pubmed publisher
    ..LPS-induced expression of PD-L1 in primary macrophages was inhibited by the PKM2 targeting compound TEPP-46. Furthermore, RNA silencing of PKM2 inhibited LPS-induced PD-L1 expression...
  6. Carpenter V, Chen Y, Dolat L, Valdivia R. The Effector TepP Mediates Recruitment and Activation of Phosphoinositide 3-Kinase on Early Chlamydia trachomatis Vacuoles. mSphere. 2017;2: pubmed publisher
    ..b>TepP is the most abundant effector protein secreted early in infection, but its molecular function is poorly understood...
  7. Beinat C, Alam I, James M, Srinivasan A, Gambhir S. Development of [18F]DASA-23 for Imaging Tumor Glycolysis Through Noninvasive Measurement of Pyruvate Kinase M2. Mol Imaging Biol. 2017;19:665-672 pubmed publisher
    ..in HeLa cells, which was effectively blocked by pretreating cells with the structurally distinct PKM2 activator, TEPP-46. [18F]DASA-23 remained intact in human and mouse serum up to 120 min...
  8. Zhang H, Wang D, Li M, Plecitá Hlavatá L, D Alessandro A, Tauber J, et al. Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Circulation. 2017;136:2468-2485 pubmed publisher
    ..PTBP1 gene knockdown was achieved via PTBP1-siRNA; restoration of miR-124 was performed with miR-124 mimic. TEPP-46 and shikonin were used to manipulate PKM2 glycolytic function...
  9. Bera T, Hahn Y, Lee B, Pastan I. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Biochem Biophys Res Commun. 2003;312:1209-15 pubmed
    ..0kb in size and encodes for a protein of 30.7kDa molecular weight. We named this gene TEPP (expressed in testis, prostate, and placenta)...

More Information

Publications18

  1. Garin Muga A, Odriozola L, Martínez Val A, Del Toro N, Martínez R, Molina M, et al. Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence. J Proteome Res. 2016;15:4101-4115 pubmed
    ..As illustrative examples, DNAH3 and TEPP in spermatozoa, and UNCX and ATAD3C in HEK293 cells were some of the more robust and remarkable identifications in ..
  2. Li Z, Zheng W, Li H, Li C, Gong Z. Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. PLoS ONE. 2015;10:e0132319 pubmed publisher
    ..and causes incomplete glycolysis to favor anabolism and tumor growth, by treatment with a Pkm2-specific activator, TEPP-46, we further demonstrated that activation of Pkm2 suppressed the growth of oncogenic liver as well as ..
  3. Palsson McDermott E, Curtis A, Goel G, Lauterbach M, Sheedy F, Gleeson L, et al. Pyruvate kinase M2 regulates Hif-1? activity and IL-1? induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21:65-80 pubmed publisher
    ..Activation of PKM2 using two well-characterized small molecules, DASA-58 and TEPP-46, inhibited LPS-induced Hif-1? and IL-1?, as well as the expression of a range of other Hif-1?-dependent genes...
  4. Hahn Y. Molecular evolution of TEPP protein genes in metazoans. Biochem Genet. 2009;47:651-64 pubmed publisher
    b>TEPP is a gene expressed in human reproductive organs such as testis, prostate, and placenta...
  5. Ugarte Avilés T, Manterola C, Cartes Velasquez R, Otzen T. Impact of proximity of thermoelectric power plants on bronchial obstructive crisis rates. BMC Public Health. 2017;17:96 pubmed publisher
    ..Energy generated by thermoelectric power plants (TEPP) represents a relevant source of pollution...
  6. Qi W, Keenan H, Li Q, Ishikado A, Kannt A, Sadowski T, et al. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med. 2017;23:753-762 pubmed publisher
    ..Conversely, we found that pharmacological activation of PKM2 by a small-molecule PKM2 activator, TEPP-46, reversed hyperglycemia-induced elevation in toxic glucose metabolites and mitochondrial dysfunction, partially ..
  7. Wang F, Wang K, Xu W, Zhao S, Ye D, Wang Y, et al. SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1? Production and to Prevent DSS-Induced Colitis in Mice. Cell Rep. 2017;19:2331-2344 pubmed publisher
    ..Activation of PKM2 using TEPP-46 attenuates Sirt5-deficiency-mediated IL-1? upregulation in LPS-stimulated macrophages...
  8. Rochtus A, Winand R, Laenen G, Vangeel E, Izzi B, Wittevrongel C, et al. Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development. Clin Epigenetics. 2016;8:108 pubmed
    ..for the top six candidate genes ABAT, CNTNAP1, SLC1A6, SNED1, SOX18, and TEPP but only for the SOX18 locus a significant overall hypomethylation was observed (P value?=?0...
  9. He C, Bian Y, Xue Y, Liu Z, Zhou K, Yao C, et al. Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1. Sci Rep. 2016;6:21524 pubmed publisher
    ..Decreasing S202/203 phosphorylation by TEPP-46 treatment reversed these effects...