tenascin X


Gene Symbol: tenascin X
Description: tenascin XB
Alias: EDS3, EDSCLL, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XBS, tenascin-X, growth-inhibiting protein 45, hexabrachion-like protein, tenascin XB1, tenascin XB2
Species: human
Products:     tenascin X

Top Publications

  1. Bristow J, Tee M, Gitelman S, Mellon S, Miller W. Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. J Cell Biol. 1993;122:265-78 pubmed
    ..Genetic data suggest that TN-X may be essential for life. ..
  2. Elefteriou F, Exposito J, Garrone R, Lethias C. Characterization of the bovine tenascin-X. J Biol Chem. 1997;272:22866-74 pubmed
    ..The functional role of this sequence is corroborated by cell adhesion on purified tenascin-X, which is inhibited by RGD peptides. Moreover, we demonstrate that this RGD site is conserved at the same location in the human molecule. ..
  3. Schalkwijk J, Zweers M, Steijlen P, Dean W, Taylor G, van Vlijmen I, et al. A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency. N Engl J Med. 2001;345:1167-75 pubmed
    ..This finding indicates that factors other than the collagens or collagen-processing enzymes can cause the syndrome and suggests a central role for tenascin-X in maintaining the integrity of collagenous matrix. ..
  4. Bristow J, Carey W, Egging D, Schalkwijk J. Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome. Am J Med Genet C Semin Med Genet. 2005;139C:24-30 pubmed
    ..Recent studies show that TNX effects on matrix extend beyond the collagen to the elastogenic pathway and matrix remodeling enzymes...
  5. Egging D, van den Berkmortel F, Taylor G, Bristow J, Schalkwijk J. Interactions of human tenascin-X domains with dermal extracellular matrix molecules. Arch Dermatol Res. 2007;298:389-96 pubmed
    Tenascin-X (TNX) is a large 450 kDa extracellular matrix protein expressed in a variety of tissues including skin, joints and blood vessels...
  6. Egging D, van Vlijmen Willems I, van Tongeren T, Schalkwijk J, Peeters A. Wound healing in tenascin-X deficient mice suggests that tenascin-X is involved in matrix maturation rather than matrix deposition. Connect Tissue Res. 2007;48:93-8 pubmed
    Tenascin-X (TNX) is an extracellular matrix glycoprotein whose absence in humans leads to a recessive form of Ehlers-Danlos Syndrome (EDS)...
  7. Gudbjartsson D, Bjornsdottir U, Halapi E, Helgadottir A, Sulem P, Jonsdottir G, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet. 2009;41:342-7 pubmed publisher
    ..2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls). ..
  8. Morel Y, Bristow J, Gitelman S, Miller W. Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus. Proc Natl Acad Sci U S A. 1989;86:6582-6 pubmed
  9. Burch G, Gong Y, Liu W, Dettman R, Curry C, Smith L, et al. Tenascin-X deficiency is associated with Ehlers-Danlos syndrome. Nat Genet. 1997;17:104-8 pubmed
    The tenascins are a family of large extracellular matrix proteins with at least three members: tenascin-X (TNX), tenascin-C (TNC, or cytotactin) and tenascin-R (TN-R, or restrictin)...

More Information

Publications117 found, 100 shown here

  1. Zweers M, van Vlijmen Willems I, van Kuppevelt T, Mecham R, Steijlen P, Bristow J, et al. Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology. J Invest Dermatol. 2004;122:885-91 pubmed
    Deficiency of the extracellular matrix protein tenascin-X (TNX) was recently described as the molecular basis of a new, recessive type of Ehlers-Danlos syndrome...
  2. Kamatani Y, Matsuda K, Ohishi T, Ohtsubo S, Yamazaki K, Iida A, et al. Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population. J Hum Genet. 2008;53:64-73 pubmed
    ..Our findings strongly imply that the TNXB gene is a candidate gene susceptible to SLE in the Japanese population. ..
  3. Zhao M, Wang W, Chen W, Ma C, Zhang F, Jiang K, et al. Genome survey, high-resolution genetic linkage map construction, growth-related quantitative trait locus (QTL) identification and gene location in Scylla paramamosain. Sci Rep. 2019;9:2910 pubmed publisher
    ..The results of this study will accelerate the genetic improvement and genome sequencing analysis of the mud crab. ..
  4. Nakayama K, Seike M, Noro R, Takeuchi S, Matsuda K, Kunugi S, et al. Tenascin XB Is a Novel Diagnostic Marker for Malignant Mesothelioma. Anticancer Res. 2019;39:627-633 pubmed publisher
    ..3% of MM cases were detected. These findings suggest that TNXB is a novel diagnostic biomarker for MM. A combination of detecting TNXB and calretinin may be useful for the differential diagnosis of MM from lung adenocarcinoma. ..
  5. Porter L, Saptarshi N, Fang Y, Rathi S, den Hollander A, de Jong E, et al. Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes. Clin Epigenetics. 2019;11:6 pubmed publisher
    ..03 × 10-7), and Tenascin X (TNXB) (p = 6.30 × 10-6) genes in AMD...
  6. Gollapudi S, Tardiff J, Chandra M. The functional effect of dilated cardiomyopathy mutation (R144W) in mouse cardiac troponin T is differently affected by α- and β-myosin heavy chain isoforms. Am J Physiol Heart Circ Physiol. 2015;308:H884-93 pubmed publisher
    ..TnTR144W also decreased the impact of strained XBs on the recruitment of new XBs (γ) by 30% only in α-MHC fibers...
  7. Bodner Adler B, Bodner K, Kimberger O, Halpern K, Schneidinger C, Haslinger P, et al. The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study. Int Urogynecol J. 2018;: pubmed publisher
    ..001). No difference could be demonstrated between tenascin-X expression in patients with or without POP. Tenascin-X does not seem to play a major role in the pathogenesis of POP in postmenopausal women. ..
  8. Reda S, Gollapudi S, Chandra M. Developmental increase in β-MHC enhances sarcomere length-dependent activation in the myocardium. J Gen Physiol. 2019;: pubmed publisher
    ..Because kinetic differences in α- and β-MHC cross-bridges (XBs) are known to impart different cooperative effects on thin filaments, we hypothesize here that differences in α- ..
  9. Goindi S, Narula M, Kalra A. Microemulsion-Based Topical Hydrogels of Tenoxicam for Treatment of Arthritis. AAPS PharmSciTech. 2016;17:597-606 pubmed publisher
    Tenoxicam (TNX) is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, backache and pain...
  10. Lee H. Variants of the CYP21A2 and CYP21A1P genes in congenital adrenal hyperplasia. Clin Chim Acta. 2013;418:37-44 pubmed publisher
  11. Geiger E, Henrich D, Wutzler S, Schneidmüller D, Jakob H, Frank J, et al. The role of TNXB single-nucleotide polymorphisms in recurrent shoulder dislocation. J Orthop Res. 2013;31:295-9 pubmed publisher
    Tenascin-X (TNX) is an extra-cellular matrix glycoprotein associated with collagen fibril deposition...
  12. Zheng W, Rao S. Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysis. Arthritis Res Ther. 2015;17:202 pubmed publisher
    ..Our results ascertained the shared genetic risk profiles that predisposed individuals to RA and other diseases, which could have implications for identification of molecular targets for drug development, and classification of diseases. ..
  13. Mizuno K, Nakane A, Nishio H, Moritoki Y, Kamisawa H, Kurokawa S, et al. Involvement of the bone morphogenic protein/SMAD signaling pathway in the etiology of congenital anomalies of the kidney and urinary tract accompanied by cryptorchidism. BMC Urol. 2017;17:112 pubmed publisher
    ..Taken together, our findings suggested that the development of the kidney and urinary tract is intimately linked with that of male reproductive organs via BMP/SMAD signaling pathways. ..
  14. Shen D, Su P, Wu W. What kind of neutral halogen bonds can be modulated by solvent effects?. Phys Chem Chem Phys. 2018;20:26126-26139 pubmed publisher
    ..For the strong XBs in a polar solvent environment, polarization is even larger than the electrostatic interaction...
  15. Li B, Qiao L, An L, Wang W, Liu J, Ren Y, et al. Transcriptome analysis of adipose tissues from two fat-tailed sheep breeds reveals key genes involved in fat deposition. BMC Genomics. 2018;19:338 pubmed publisher
    ..Further studies are needed to investigate the roles of the candidate genes in fat deposition and in determining the meat quality of sheep. ..
  16. Tajuddin S, Schick U, Eicher J, Chami N, Giri A, Brody J, et al. Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. Am J Hum Genet. 2016;99:22-39 pubmed publisher
    ..These association results shed light on genetic mechanisms that regulate circulating WBC counts and suggest a prominent shared genetic architecture with inflammatory and autoimmune diseases. ..
  17. Boileau A, Lalem T, Vausort M, Zhang L, Devaux Y. A 3-gene panel improves the prediction of left ventricular dysfunction after acute myocardial infarction. Int J Cardiol. 2018;254:28-35 pubmed publisher
    ..A 3-gene panel can aid to predict LV dysfunction after MI. Further independent validation is required before considering these findings for molecular diagnostic assay development. ..
  18. Pinheiro M, Drigo S, Tonhosolo R, Andrade S, Marchi F, Jurisica I, et al. HABP2 p.G534E variant in patients with family history of thyroid and breast cancer. Oncotarget. 2017;8:40896-40905 pubmed publisher
  19. Kim H, Woo S, Suh E, Ahn J, Park J, Hong H, et al. Identification of vinculin as a potential plasma marker for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;55:7166-76 pubmed publisher
    ..triosephosphate isomerase, protein S100A8, protein Z-dependent protease inhibitor, C-X-C motif chemokine 7, and tenascin X showed significantly differential expression in AMD patient plasma compared to control plasma...
  20. Zweers M, Peeters A, Graafsma S, Kranendonk S, van der Vliet J, den Heijer M, et al. Abdominal aortic aneurysm is associated with high serum levels of tenascin-X and decreased aneurysmal tissue tenascin-X. Circulation. 2006;113:1702-7 pubmed
    ..3; 95% confidence interval, 2.0 to 13.8). Tenascin-X expression is markedly decreased in AAA tissue, and AAA is associated with high serum concentrations of tenascin-X. ..
  21. Das B, Kumari R, Pant A, Sen Gupta S, Saxena S, Mehta O, et al. A novel, broad-range, CTXΦ-derived stable integrative expression vector for functional studies. J Bacteriol. 2014;196:4071-80 pubmed publisher
    ..genome forms intramolecular base-pairing interactions between two inversely oriented XerC and XerD binding sites (XBS) and generates a functional phage attachment site, attP(+), for integration...
  22. Belden J, Lotufo G, Biedenbach J, Sieve K, Rosen G. Application of POCIS for exposure assessment of munitions constituents during constant and fluctuating exposure. Environ Toxicol Chem. 2015;34:959-67 pubmed publisher
    ..aminodinitrotoluenes [ADNTs], diaminonitrotoluenes [DANTs], and hexahydro-1,3,5-trinitroso-1,3,5-triazine [TNX])...
  23. Murillo A, Muñoz M, Martín González D, Carrocera S, Martínez Nistal A, Gómez E. Low serum concentration in bovine embryo culture enhances early blastocyst rates on Day-6 with quality traits in the expanded blastocyst stage similar to BSA-cultured embryos. Reprod Biol. 2017;17:162-171 pubmed publisher
    ..minute FCS concentration improves EB rates on Day-6 leading, after one-day single culture without protein, to more XBs. The quality of XB produced with FCS compares well with XB produced with BSA in terms of apoptosis, lipid ..
  24. Wain L, Vaez A, Jansen R, Joehanes R, van der Most P, Erzurumluoglu A, et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017;: pubmed publisher
    ..Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation. ..
  25. Duggal D, Nagwekar J, Rich R, Huang W, Midde K, Fudala R, et al. Effect of a myosin regulatory light chain mutation K104E on actin-myosin interactions. Am J Physiol Heart Circ Physiol. 2015;308:H1248-57 pubmed publisher
    ..best studied when an individual XB makes a significant contribution to the overall signal, the number of observed XBs in an ex vivo ventricle was minimized to ∼20...
  26. Chang J, Zhong R, Tian J, Li J, Zhai K, Ke J, et al. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet. 2018;50:338-343 pubmed publisher
    ..0004), most likely due to an enhanced capacity of variant CYP26B1 to catabolize this agent. These findings emphasize the important role of rare coding variants in the development of ESCC. ..
  27. Herchenhan A, Uhlenbrock F, Eliasson P, Weis M, Eyre D, Kadler K, et al. Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells. J Biol Chem. 2015;290:16440-50 pubmed publisher
    ..Collectively, the data show the importance of LOX for the mechanical development of early collagenous tissues and that LOX is essential for correct collagen fibril shape formation. ..
  28. Malfait F. Vascular aspects of the Ehlers-Danlos Syndromes. Matrix Biol. 2018;71-72:380-395 pubmed publisher
    ..This review summarizes current knowledge on manifestations of vascular fragility in the different EDS subtypes. ..
  29. Razmazma H, Ebrahimi A. The effects of cation-? and anion-? interactions on halogen bonds in the [N?X?N]+ complexes: A comprehensive theoretical study. J Mol Graph Model. 2018;84:134-144 pubmed publisher
    ..sup>1JN?X and 1XJN?X have opposite signs in closed and shared shell XBs. The obtained potential curves can be applied as valuable data to describe the effect of ion-? interaction on the ..
  30. Dubost A, Micol D, Lethias C, Listrat A. New insight of some extracellular matrix molecules in beef muscles. Relationships with sensory qualities. Animal. 2016;10:821-8 pubmed publisher
  31. Adasme Carreño F, Alzate Morales J, Ireta J. Modeling cooperative effects in halogen-bonded infinite linear chains. Phys Chem Chem Phys. 2017;19:18529-18538 pubmed publisher
    ..This outcome reveals differences in the nature of the XBs formed in these molecular systems...
  32. Otabe K, Nakahara H, Hasegawa A, Matsukawa T, Ayabe F, Onizuka N, et al. Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. J Orthop Res. 2015;33:1-8 pubmed publisher
    ..Thus, MKX is a key factor for tenogenic differentiation of MSCs. ..
  33. Reda S, Chandra M. Cardiomyopathy mutation (F88L) in troponin T abolishes length dependency of myofilament Ca2+ sensitivity. J Gen Physiol. 2018;150:809-819 pubmed publisher
    ..of TnT is important for modulating the muscle length-mediated recruitment of new force-bearing cross-bridges (XBs), we hypothesize that the F87L mutation causes molecular changes that are linked to the length-dependent activation ..
  34. Riel A, Decato D, Sun J, Massena C, Jessop M, Berryman O. The intramolecular hydrogen bonded-halogen bond: a new strategy for preorganization and enhanced binding. Chem Sci. 2018;9:5828-5836 pubmed publisher
    ..NMR solution studies established the efficacy of the HB-XB. The receptor with HB-XBs (G2XB) displayed a nearly 9-fold increase in halide binding over control receptors...
  35. Sakiyama T, Kubo A, Sasaki T, Yamada T, Yabe N, Matsumoto K, et al. Recurrent gastrointestinal perforation in a patient with Ehlers-Danlos syndrome due to tenascin-X deficiency. J Dermatol. 2015;42:511-4 pubmed publisher
  36. Wang K, Zhao S, Zhang Q, Yuan J, Liu J, Ding X, et al. Whole-exome sequencing reveals known and novel variants in a cohort of intracranial vertebral-basilar artery dissection (IVAD). J Hum Genet. 2018;63:1119-1128 pubmed publisher
    ..002) (DISCO study, http://www.discostudy.org/ , n = 2248). Our study provided a mutational landscape for patients with isolated IVAD. ..
  37. Kramer M, Pierredon S, Ribaux P, Tille J, Petignat P, Cohen M. Secretome Identifies Tenascin-X as a Potent Marker of Ovarian Cancer. Biomed Res Int. 2015;2015:208017 pubmed publisher
    ..Using this method, we determined tenascin-X as a new potent marker for serous ovarian cancer. ..
  38. Friedenberg S, Meurs K, Mackay T. Evaluation of artificial selection in Standard Poodles using whole-genome sequencing. Mamm Genome. 2016;27:599-609 pubmed
  39. Morano D, Berto S, Lapucci C, Walczer Baldinazzo L, Prandstraller D, Farina A. Levels of Circulating mRNA for the Tenascin-X (TNXB) Gene in Maternal Plasma at the Second Trimester in Pregnancies with Isolated Congenital Ventricular Septal Defects. Mol Diagn Ther. 2018;22:235-240 pubmed publisher
    ..The positive predictive value of this molecular marker in the general population should be assessed through prospective studies. ..
  40. Chen W, Xu Z, Nishitani M, Van Ryzin C, McDonnell N, Merke D. Complement component 4 copy number variation and CYP21A2 genotype associations in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Hum Genet. 2012;131:1889-94 pubmed publisher
    ..In this study, we performed comprehensive genetic analysis of the RP-C4-CYP21-TNX (RCCX) region in 127 unrelated 21-OHD patients (100 classic, 27 nonclassic)...
  41. Morissette R, Merke D, McDonnell N. Transforming growth factor-β (TGF-β) pathway abnormalities in tenascin-X deficiency associated with CAH-X syndrome. Eur J Med Genet. 2014;57:95-102 pubmed publisher
  42. Yamada K, Watanabe A, Takeshita H, Matsumoto K. A method for quantification of serum tenascin-X by nano-LC/MS/MS. Clin Chim Acta. 2016;459:94-100 pubmed publisher
    Complete deficiency of an extracellular matrix tenascin-X (TNX) leads to a classical type of Ehlers-Danlos syndrome (EDS). TNX haploinsufficiency is a cause of hypermobility type of EDS...
  43. Grune J, Beyhoff N, Smeir E, Chudek R, Blumrich A, Ban Z, et al. Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone's Antifibrotic Activity. Hypertension. 2018;71:599-608 pubmed publisher
    ..Antifibrotic actions of finerenone were accompanied by a significant inhibition of profibrotic cardiac TNX (tenascin-X) expression, a regulation absent with eplerenone...
  44. Chen W, Kim M, Shanbhag S, Arai A, VanRyzin C, McDonnell N, et al. The phenotypic spectrum of contiguous deletion of CYP21A2 and tenascin XB: quadricuspid aortic valve and other midline defects. Am J Med Genet A. 2009;149A:2803-8 pubmed publisher
    ..The genes encoding 21-hydroxylase, CYP21A2, and tenascin-X (TNX), TNXB, are located within the HLA complex, in a region of high gene density termed the RCCX module...
  45. Imai A, Matsunami K, Ichigo S, Takagi H. Minodronic acid suppresses gonadotropin-releasing hormone agonist-induced bone remodeling biomarkers: a retrospective pilot study. Gynecol Endocrinol. 2016;32:250-2 pubmed publisher
    ..Women receiving a GnRHa had a significant increase in urinary DPD and TNX at 6 months while minodronic acid during GnRHa therapy improved urinary levels of DPD and NTX to near baseline...
  46. Men C, Chai H, Song X, Li Y, Du H, Ren Q. Identification of DNA methylation associated gene signatures in endometrial cancer via integrated analysis of DNA methylation and gene expression systematically. J Gynecol Oncol. 2017;28:e83 pubmed publisher
    ..PCDHs clusters, DDP6, and TNXB were firstly found to be associated with tumorigenesis, and may be novel candidate biomarkers for EC. ..
  47. Carignano H, Roldan D, Beribe M, Raschia M, Amadio A, Nani J, et al. Genome-wide scan for commons SNPs affecting bovine leukemia virus infection level in dairy cattle. BMC Genomics. 2018;19:142 pubmed publisher
    ..Data obtained represent a step forward to understand the biology of BLV-bovine interaction, and provide genetic information potentially applicable to selective breeding programs. ..
  48. Egging D, Peeters A, Grebenchtchikov N, Geurts Moespot A, Sweep C, Den Heijer M, et al. Identification and characterization of multiple species of tenascin-X in human serum. FEBS J. 2007;274:1280-9 pubmed
    We analysed the diversity of tenascin-X (TNX) species in serum and studied parameters that could affect determination of TNX levels in serum...
  49. Kesselmeier M, Pütter C, Volckmar A, Baurecht H, Grallert H, Illig T, et al. High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation. World J Biol Psychiatry. 2018;19:187-199 pubmed publisher
    ..We confirm genes like TNXB previously described to comprise differentially methylated sites, and highlight further sites that might be specifically involved in AN starvation processes. ..
  50. Liang Y, Kuo D, Allen H, Di Toro D. Experimental determination of solvent-water partition coefficients and Abraham parameters for munition constituents. Chemosphere. 2016;161:429-437 pubmed publisher
    ..HMX), hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX), hexahydro-1,3-dinitroso-5- nitro-1,3,5-triazine (DNX), 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitrobenzene (TNB), ..
  51. Morissette R, Chen W, Perritt A, Dreiling J, Arai A, Sachdev V, et al. Broadening the Spectrum of Ehlers Danlos Syndrome in Patients With Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. 2015;100:E1143-52 pubmed publisher
    ..necessary for cortisol biosynthesis, and TNXB, encoding the extracellular matrix glycoprotein tenascin-X (TNX)...
  52. Chandra V, Gollapudi S, Chandra M. Rat cardiac troponin T mutation (F72L)-mediated impact on thin filament cooperativity is divergently modulated by α- and β-myosin heavy chain isoforms. Am J Physiol Heart Circ Physiol. 2015;309:H1260-70 pubmed publisher
    ..TnTF72L increased the negative impact of strained XBs on the force-bearing XBs by 39% in α-MHC fibers but had no effect in β-MHC fibers...
  53. Won J, Borden R. Impact of glycerin and lignosulfonate on biodegradation of high explosives in soil. J Contam Hydrol. 2016;194:1-9 pubmed publisher
    ..under anaerobic conditions, without accumulation of TNT or RDX daughter products (2-ADNT, 4-ADNT, MNX, DNX, and TNX)...
  54. Heerspink B, Pandey S, Boukhalfa H, Ware D, Marina O, Perkins G, et al. Fate and transport of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and its degradation products in sedimentary and volcanic rocks, Los Alamos, New Mexico. Chemosphere. 2017;182:276-283 pubmed publisher
    ..to determine the extent of adsorption-desorption and transport of RDX and its degradation products (MNX, DNX, and TNX) in major rock types that are within the RDX plume...
  55. Mandaviya P, Aïssi D, Dekkers K, Joehanes R, Kasela S, Truong V, et al. Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis. Epigenomics. 2017;9:1403-1422 pubmed publisher
    ..8-kb spanning domain (TNXB/ATF6B) at chromosome 6. We identified novel epigenetic loci associated with Hcy levels, of which specific role needs to be further validated. ..
  56. Hashimoto K, Kajitani N, Miyamoto Y, Matsumoto K. Wound healing-related properties detected in an experimental model with a collagen gel contraction assay are affected in the absence of tenascin-X. Exp Cell Res. 2018;363:102-113 pubmed publisher
    Patients with tenascin-X (TNX)-deficient type Ehlers-Danlos syndrome (EDS) do not exhibit delayed wound healing, unlike classic type EDS patients, who exhibit mutations in collagen genes...
  57. Sakai H, Yokota S, Kajitani N, Yoneyama T, Kawakami K, Yasui Y, et al. A potential contribution of tenascin-X to blood vessel formation in peripheral nerves. Neurosci Res. 2017;124:1-7 pubmed publisher
    Tenascin-X (TNX), an extracellular matrix protein, is abundantly expressed in peripheral nerves. However, the physiological role of TNX in peripheral nerves remains unknown...
  58. Gitelman S, Bristow J, Miller W. Mechanism and consequences of the duplication of the human C4/P450c21/gene X locus. Mol Cell Biol. 1992;12:2124-34 pubmed
    ..Nevertheless, XA is transcribed into a stable 2.6-kb polyadenylated RNA that is expressed uniquely in the adrenal gland. ..
  59. Elahi S, Homstad A, Vaidya H, Stout J, Hall G, Wu G, et al. Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux. Pediatr Nephrol. 2016;31:247-53 pubmed publisher
  60. Mamidi R, Li J, Gresham K, Verma S, Doh C, Li A, et al. Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium. Circ Heart Fail. 2017;10: pubmed publisher
    Omecamtiv mecarbil (OM) enhances systolic function in vivo by directly binding the myosin cross-bridges (XBs) in the sarcomere...
  61. Tee M, Thomson A, Bristow J, Miller W. Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X. Genomics. 1995;28:171-8 pubmed
    ..RNase protection assays, cDNA cloning, and RT/PCR show that adrenal cells contain a novel transcript, termed short XB (XB-S), which has the same open reading frame as TN-X.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  62. Speek M, Barry F, Miller W. Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes. Hum Mol Genet. 1996;5:1749-58 pubmed
    ..RACE cloning and RNase protection experiments reveal no such alternate splicing. The TN-X gene appears to be unique in having both its 5' and 3' ends buried in other genes. ..
  63. Liu L, Wei J, Zhang X, Li X, Shen Y, Liu S, et al. Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population. Neurosci Lett. 2004;355:149-51 pubmed
    A recent study demonstrated that the tenascin X (TNXB) gene was associated with schizophrenia in a British population...
  64. Fust G, Arason G, Kramer J, Szalai C, Duba J, Yang Y, et al. Genetic basis of tobacco smoking: strong association of a specific major histocompatibility complex haplotype on chromosome 6 with smoking behavior. Int Immunol. 2004;16:1507-14 pubmed
  65. Zweers M, Dean W, van Kuppevelt T, Bristow J, Schalkwijk J. Elastic fiber abnormalities in hypermobility type Ehlers-Danlos syndrome patients with tenascin-X mutations. Clin Genet. 2005;67:330-4 pubmed
    ..a clinically distinct, recessive type of EDS caused by deficiency of the extracellular matrix protein tenascin-X (TNX). Interestingly, haploinsufficiency of TNX is associated with the dominantly inherited hypermobility type of EDS...
  66. Egging D, van Vlijmen Willems I, Choi J, Peeters A, van Rens D, Veit G, et al. Analysis of obstetric complications and uterine connective tissue in tenascin-X-deficient humans and mice. Cell Tissue Res. 2008;332:523-32 pubmed publisher
    Tenascin-X (TNX) is a large, multi-domain, extracellular matrix glycoprotein. Complete deficiency of TNX in humans leads to a recessive form of Ehlers-Danlos syndrome (EDS), and TNX haploinsufficiency is a cause of hypermobility type EDS...
  67. Kahn N, Meister M, Eberhardt R, Muley T, Schnabel P, Bender C, et al. Early detection of lung cancer by molecular markers in endobronchial epithelial-lining fluid. J Thorac Oncol. 2012;7:1001-8 pubmed publisher
    ..Our study suggests that the analysis of specific biomarkers in ELF collected by BMS could be a potentially useful adjunct to other diagnostic techniques aiming at the preoperative diagnosis of malignant pulmonary nodules. ..
  68. Merke D, Chen W, Morissette R, Xu Z, Van Ryzin C, Sachdev V, et al. Tenascin-X haploinsufficiency associated with Ehlers-Danlos syndrome in patients with congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2013;98:E379-87 pubmed publisher
    ..A subset of parents had clinical findings. Clinical evaluation for connective tissue dysplasia should be routinely performed in CAH patients, especially those harboring a CYP21A2 deletion. ..
  69. Weidinger S, Willis Owen S, Kamatani Y, Baurecht H, Morar N, Liang L, et al. A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Hum Mol Genet. 2013;22:4841-56 pubmed publisher
    ..Our results indicate that the pathogenesis of AD incorporates immune and epidermal barrier defects with combinations of specific and overlapping effects at individual loci. ..
  70. Scholfield M, Ford M, Carlsson A, Butta H, Mehl R, Ho P. Structure-Energy Relationships of Halogen Bonds in Proteins. Biochemistry. 2017;56:2794-2802 pubmed publisher
    ..In this study, we have designed and engineered halogen bonds (XBs) site-specifically to study their structure-energy relationship in a model protein, T4 lysozyme...
  71. Kurihara K, Sato I. Distribution of tenascin-C and -X, and soft X-ray analysis of the mandibular symphysis during mandible formation in the human fetus. Okajimas Folia Anat Jpn. 2004;81:49-55 pubmed
  72. Goepel C. Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with and without pelvic organ prolapse. Acta Histochem. 2008;110:204-9 pubmed
    ..These data indicate a complex architecture of the extracellular matrix in the uterosacral ligaments, with marked differences in tenascin and elastin expression between postmenopausal women with or without POP...
  73. Vignal C, Bansal A, Balding D, Binks M, Dickson M, Montgomery D, et al. Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. Arthritis Rheum. 2009;60:53-62 pubmed publisher
    ..These results confirm the polygenic contribution of the MHC to RA and implicate 2 additional non-DRB1 susceptibility loci. The role of the HLA-DQ locus in RA has been a subject of controversy, but in our data, it appears to be spurious. ..
  74. Matsumoto K, Satoh K, Maniwa T, Araki A, Maruyama R, Oda T. Noticeable decreased expression of tenascin-X in calcific aortic valves. Connect Tissue Res. 2012;53:460-8 pubmed publisher
    ..We confirmed decreased levels of these proteins in CAVs by Western blot analyses. These results indicated that massive destruction of the extracellular matrix occurs in CAVs. ..
  75. Lu X, Wang L, Lin X, Huang J, Charles Gu C, He M, et al. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. Hum Mol Genet. 2015;24:865-74 pubmed publisher
    ..81 × 10(-3) to 5.16 × 10(-8). These findings provide new mechanistic insights into the regulation of blood pressure and potential targets for treatments. ..
  76. Salmon C, Giorgetti A, Paes Leme A, Domingues R, Sallum E, Alves M, et al. Global proteome profiling of dental cementum under experimentally-induced apposition. J Proteomics. 2016;141:12-23 pubmed publisher
    ..the interaction between EIA and time (12 proteins), including serpin 1a, procollagen C-endopeptidase enhancer, tenascin X (TNX), and asporin (ASPN)...
  77. Mustoe C, Gunabalasingam M, Yu D, Patrick B, Kennepohl P. Probing covalency in halogen bonds through donor K-edge X-ray absorption spectroscopy: polyhalides as coordination complexes. Faraday Discuss. 2017;203:79-91 pubmed publisher
    The properties of halogen bonds (XBs) in solid-state I2X- and I4X- materials (where X = Cl, Br) are explored using donor K-edge X-ray absorption spectroscopy (XAS) to experimentally determine ..
  78. Rupert K, Rennebohm R, Yu C. An unequal crossover between the RCCX modules of the human MHC leading to the presence of a CYP21B gene and a tenascin TNXB/TNXA-RP2 recombinant between C4A and C4B genes in a patient with juvenile rheumatoid arthritis. Exp Clin Immunogenet. 1999;16:81-97 pubmed
    ..III region is comprised of four genes arranged in tandem: RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin X (TNX). Variations in the number and genes of the RCCX modules may lead to genetic and/or autoimmune diseases...
  79. Ikuta T, Ariga H, Matsumoto K. Extracellular matrix tenascin-X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation. Genes Cells. 2000;5:913-927 pubmed
    An extracellular matrix tenascin-X (TNX) is highly expressed in muscular tissues, especially heart and skeletal muscle, and is also prominent around blood vessels. The precise in vivo role of TNX remains to be elucidated...
  80. Kato A, Endo T, Abiko S, Ariga H, Matsumoto K. Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. Exp Cell Res. 2008;314:2661-73 pubmed publisher
    XB-S is an amino-terminal truncated protein of tenascin-X (TNX) in humans. The levels of the XB-S transcript, but not those of TNX transcripts, were increased upon hypoxia...
  81. Zhuang S, Linhananta A, Li H. Phenotypic effects of Ehlers-Danlos syndrome-associated mutation on the FnIII domain of tenascin-X. Protein Sci. 2010;19:2231-9 pubmed publisher
    Tenascin-X (TNX) is an extracellular matrix (ECM) protein and interacts with a wide variety of molecules in the ECM as well as on the membrane...
  82. Wang J, Sun S, Zhang L, Wang Z, Ye L, Liu L, et al. Further study of genetic association between the TNXB locus and schizophrenia. Psychiatr Genet. 2011;21:216 pubmed publisher
  83. Chung S, Taylor K, Graham R, Nititham J, Lee A, Ortmann W, et al. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet. 2011;7:e1001323 pubmed publisher
    ..Lack of strong SNP associations may suggest that other types of genetic variation or non-genetic factors such as environmental exposures have a greater impact on susceptibility to anti-dsDNA - SLE. ..
  84. Matsumoto K. [Vascular Calcification - Pathological Mechanism and Clinical Application - . Extracellular matrix tenascin-X in calcific aortic valves]. Clin Calcium. 2015;25:701-10 pubmed publisher
    We previously disclosed a novel extracellular matrix tenascin-X (TNX) , the largest member of the tenascin family. So far, we have made efforts to elucidate the roles of TNX...
  85. Demirdas S, Dulfer E, Robert L, Kempers M, van Beek D, Micha D, et al. Recognizing the tenascin-X deficient type of Ehlers-Danlos syndrome: a cross-sectional study in 17 patients. Clin Genet. 2017;91:411-425 pubmed publisher
    The tenascin-X (TNX) deficient type Ehlers-Danlos syndrome (EDS) is similar to the classical type of EDS...
  86. Yang Z, Mendoza A, Welch T, Zipf W, Yu C. Modular variations of the human major histocompatibility complex class III genes for serine/threonine kinase RP, complement component C4, steroid 21-hydroxylase CYP21, and tenascin TNX (the RCCX module). A mechanism for gene deletions and disease ass. J Biol Chem. 1999;274:12147-56 pubmed
    ..As shown by definitive RFLPs, the tandemly arranged genes RP, C4, CYP21, and TNX are duplicated together as a discrete genetic unit termed the RCCX module...
  87. Jaatinen T, Chung E, Ruuskanen O, Lokki M. An unequal crossover event in RCCX modules of the human MHC resulting in the formation of a TNXB/TNXA hybrid and deletion of the CYP21A. Hum Immunol. 2002;63:683-9 pubmed
    ..central region of the human major histocompatibility complex contains tandemly arranged genes of RP, C4, CYP21, and TNX. The C4 gene region is prone to rearrangements that generates duplications, conversions, and deletions...
  88. Koppens P, Smeets H, de Wijs I, Degenhart H. Mapping of a de novo unequal crossover causing a deletion of the steroid 21-hydroxylase (CYP21A2) gene and a non-functional hybrid tenascin-X (TNXB) gene. J Med Genet. 2003;40:e53 pubmed
  89. Lévy P, Ripoche H, Laurendeau I, Lazar V, Ortonne N, Parfait B, et al. Microarray-based identification of tenascin C and tenascin XB, genes possibly involved in tumorigenesis associated with neurofibromatosis type 1. Clin Cancer Res. 2007;13:398-407 pubmed
    ..Anti-TNC antibodies, already used successfully in clinical trials to treat malignant human gliomas, may be an appropriate new therapeutic strategy for NF1. ..
  90. McKinnon E, Morahan G, Nolan D, James I. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. Diabetes Obes Metab. 2009;11 Suppl 1:92-100 pubmed publisher
    ..While many of the associations can be attributed to LD between the SNPs and the dominant HLA-DRB/DQA/DQB loci, there is also evidence of additional modifying effects. ..
  91. Yang X, Sun J, Gao Y, Tan A, Zhang H, Hu Y, et al. Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects. PLoS Genet. 2012;8:e1002916 pubmed publisher
    ..Our study is the first GWAS report which shows genetic components influence the levels of complement C3 and C4. Our significant findings provide novel insights of their related autoimmune, infectious diseases, and molecular mechanisms...