telethonin

Summary

Gene Symbol: telethonin
Description: titin-cap
Alias: CMD1N, CMH25, LGMD2G, T-cap, TELE, telethonin, telethonin, 19 kDa sarcomeric protein, limb girdle muscular dystrophy 2G (autosomal recessive), teneurin C-terminal associated peptide, titin cap protein
Species: human
Products:     telethonin

Top Publications

  1. Valle G, Faulkner G, De Antoni A, Pacchioni B, Pallavicini A, Pandolfo D, et al. Telethonin, a novel sarcomeric protein of heart and skeletal muscle. FEBS Lett. 1997;415:163-8 pubmed
    In this paper we describe a novel 19 kDa sarcomeric protein named telethonin. The cDNA sequence discloses an open reading frame of 167 amino acids that does not resemble any known protein...
  2. Pinotsis N, Petoukhov M, Lange S, Svergun D, Zou P, Gautel M, et al. Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. J Struct Biol. 2006;155:239-50 pubmed
    ..into an antiparallel (2:1) sandwich complex by the N-terminal titin-binding segment of the Z-disk ligand telethonin/T-cap [Zou, P., Pinotsis, N., Lange, S., Song, Y.H., Popov, A., Mavridis, I., Mayans, O.M., Gautel, M...
  3. Bertz M, Wilmanns M, Rief M. The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc Natl Acad Sci U S A. 2009;106:13307-133310 pubmed publisher
    ..In skeletal muscle, the giant protein titin is anchored in the Z-disk by telethonin. Much of the structural integrity of the Z-disk hinges upon the titin-telethonin bond...
  4. Gregorio C, Trombitas K, Centner T, Kolmerer B, Stier G, Kunke K, et al. The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. J Cell Biol. 1998;143:1013-27 pubmed
  5. Faulkner G, Lanfranchi G, Valle G. Telethonin and other new proteins of the Z-disc of skeletal muscle. IUBMB Life. 2001;51:275-82 pubmed
    ..titin, nebulin, and alpha-actinin 2, several other Z-disc proteins have been recently discovered, including telethonin and myotilin that have been linked to limb girdle muscular dystrophies...
  6. Hayashi T, Arimura T, Itoh Satoh M, Ueda K, Hohda S, Inagaki N, et al. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol. 2004;44:2192-201 pubmed
    ..These observations suggest that the difference in clinical phenotype (HCM or DCM) may be correlated with the property of altered binding among the Z-disc components. ..
  7. Bos J, Poley R, Ny M, Tester D, Xu X, Vatta M, et al. Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin. Mol Genet Metab. 2006;88:78-85 pubmed
    TTN-encoded titin, CSRP3-encoded muscle LIM protein, and TCAP-encoded telethonin are Z-disc proteins essential for the structural organization of the cardiac sarcomere and the cardiomyocyte's stretch sensor...
  8. Lee E, Gao M, Pinotsis N, Wilmanns M, Schulten K. Mechanical strength of the titin Z1Z2-telethonin complex. Structure. 2006;14:497-509 pubmed
    Using molecular dynamics simulations, we have explored the mechanical strength of the titin Z1Z2-telethonin complex, namely, its ability to bear strong forces such as those encountered during passive muscle stretch...
  9. Moreira E, Vainzof M, Marie S, Sertié A, Zatz M, Passos Bueno M. The seventh form of autosomal recessive limb-girdle muscular dystrophy is mapped to 17q11-12. Am J Hum Genet. 1997;61:151-9 pubmed
    ..We suggest that this form, which, interestingly, clinically resembles AR Kugelberg-Welander disease, should be classified as LGMD2G. In addition, our results indicate the existence of still another locus causing severe LGMD.

More Information

Publications107 found, 100 shown here

  1. Mues A, van der Ven P, Young P, Fürst D, Gautel M. Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin. FEBS Lett. 1998;428:111-4 pubmed
    ..We describe here that the N-terminal titin immunoglobulin domains Z1 and Z2 interact specifically with telethonin in yeast two-hybrid analysis and protein binding assays...
  2. Mayans O, van der Ven P, Wilm M, Mues A, Young P, Fürst D, et al. Structural basis for activation of the titin kinase domain during myofibrillogenesis. Nature. 1998;395:863-9 pubmed
    ..Titin kinase phosphorylates the muscle protein telethonin in early differentiating myocytes, indicating that this kinase may act in myofibrillogenesis.
  3. Zou P, Gautel M, Geerlof A, Wilmanns M, Koch M, Svergun D. Solution scattering suggests cross-linking function of telethonin in the complex with titin. J Biol Chem. 2003;278:2636-44 pubmed
    b>Telethonin interacts specifically with the two Z-disk IG-like domains (Z1Z2) at the N terminus of titin, the largest presently known protein...
  4. Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, et al. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J Mol Biol. 2004;339:313-25 pubmed
    ..Here, we show that Ankrd2 is able to interact with the Z-disc protein telethonin as well as being able to interact with three transcription factors: YB-1, PML and p53...
  5. Zou P, Pinotsis N, Lange S, Song Y, Popov A, Mavridis I, et al. Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Nature. 2006;439:229-33 pubmed
    ..the giant muscle protein titin, is assembled into an antiparallel (2:1) sandwich complex by the Z-disk ligand telethonin. The pseudosymmetric structure of telethonin mediates a unique palindromic arrangement of two titin filaments, a ..
  6. Tian L, Li H, Jin B, Pan X, Man J, Zhang P, et al. MDM2 interacts with and downregulates a sarcomeric protein, TCAP. Biochem Biophys Res Commun. 2006;345:355-61 pubmed
    ..Further investigation will focus on the biological significance of MDM2-TCAP interaction in cardiac hypertrophy. ..
  7. Furukawa T, Ono Y, Tsuchiya H, Katayama Y, Bang M, Labeit D, et al. Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. J Mol Biol. 2001;313:775-84 pubmed
    ..We report here that minK specifically interacts with the sarcomeric Z-line component, T-cap (also called telethonin)...
  8. Nicholas G, Thomas M, Langley B, Somers W, Patel K, Kemp C, et al. Titin-cap associates with, and regulates secretion of, Myostatin. J Cell Physiol. 2002;193:120-31 pubmed
    ..These results suggest that T-cap, by interacting with Myostatin, controls Myostatin secretion in myogenic precursor cells without affecting the processing step of precursor Myostatin. ..
  9. Knoll R, Hoshijima M, Hoffman H, Person V, Lorenzen Schmidt I, Bang M, et al. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002;111:943-55 pubmed
    ..MLP interacts with and colocalizes with telethonin (T-cap), a titin interacting protein...
  10. Zhang R, Yang J, Zhu J, Xu X. Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly. Hum Mol Genet. 2009;18:4130-40 pubmed publisher
    Tcap/telethonin encodes a Z-disc protein that plays important roles in sarcomere assembly, sarcomere-membrane interaction and stretch sensing...
  11. Moreira E, Wiltshire T, Faulkner G, Nilforoushan A, Vainzof M, Suzuki O, et al. Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin. Nat Genet. 2000;24:163-6 pubmed
    ..2 Mb. The gene encoding telethonin, a sarcomeric protein, lies within this candidate region...
  12. Frey N, Olson E. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. J Biol Chem. 2002;277:13998-4004 pubmed
    ..calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin. In addition, we show that calsarcins interact with the PDZ-LIM domain protein ZASP/Cypher/Oracle, which also ..
  13. Waddell L, Tran J, Zheng X, Bönnemann C, Hu Y, Evesson F, et al. A study of FHL1, BAG3, MATR3, PTRF and TCAP in Australian muscular dystrophy patients. Neuromuscul Disord. 2011;21:776-81 pubmed publisher
    ..In conclusion, we have excluded these five genes as common causes of muscular dystrophy in Australia. Patients with reducing body myopathy may be initially diagnosed as muscular dystrophy. ..
  14. Fleischer I, Schæbel L, Albertsen N, Sørensen V, Andersen S. Diagnosis of osteoporosis in rural Arctic Greenland: a clinical case using plain chest radiography for secondary prevention and consideration of tools for primary prevention in remote areas. Rural Remote Health. 2017;17:3910 pubmed
    ..They are transferred to the hospital in the capital city Nuuk using existing tele-technology, and specialist evaluations are given in electronic records available at the coastal hospitals...
  15. Rimmer J, Thirumalai M, Young H, Pekmezi D, Tracy T, Riser E, et al. Rationale and design of the tele-exercise and multiple sclerosis (TEAMS) study: A comparative effectiveness trial between a clinic- and home-based telerehabilitation intervention for adults with multiple sclerosis (MS) living in the deep south. Contemp Clin Trials. 2018;71:186-193 pubmed publisher
    ..Clinical Trials.gov Identifier: NCT03117881. ..
  16. Zuppinger C, Gibbons G, Dutta Passecker P, Segiser A, Most H, Suter T. Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes. Eur J Histochem. 2017;61:2763 pubmed publisher
    ..for some muscle proteins, such as for myosin light chains, or incomplete organization in sarcomeres, such as for telethonin. These observations indicate that hiPSC-CMs can be considered genuine human cardiomyocytes of an early ..
  17. Colacci M, De Almeida R, Chand D, Lovejoy S, Sephton D, Vercaemer B, et al. Characterization of the teneurin C-terminal associated peptide (TCAP) in the vase tunicate, Ciona intestinalis: A novel peptide system associated with energy metabolism and reproduction. Gen Comp Endocrinol. 2015;216:161-70 pubmed publisher
    ..intestinalis. Thus, C. intestinalis and tunicates in general may offer a simple model to investigate peptide interaction while providing information on how to control this invasive species. ..
  18. Piga M, Cangemi I, Mathieu A, Cauli A. Telemedicine for patients with rheumatic diseases: Systematic review and proposal for research agenda. Semin Arthritis Rheum. 2017;47:121-128 pubmed publisher
    To systematically review the scientific literature regarding tele-rheumatology and draw conclusions about feasibility, effectiveness, and patient satisfaction...
  19. Gitaka J, Natecho A, Mwambeo H, Gatungu D, Githanga D, Abuya T. Evaluating quality neonatal care, call Centre service, tele-health and community engagement in reducing newborn morbidity and mortality in Bungoma county, Kenya. BMC Health Serv Res. 2018;18:493 pubmed publisher
    ..The funding and ethical approvals have been obtained and the study commenced. PACTR201712002802638 Retrospectively registered on 5th December 2017 at Pan African Clinical Trials Registry. ..
  20. Deisz R, Marx G. [Telemedicine in the ICU - the possibilities and limitations of an innovation]. Med Klin Intensivmed Notfmed. 2016;111:723-728 pubmed
    ..In addition, tele-consulting significantly reduced the ICU- and hospital length of stay...
  21. Cécile P, Julien A, Andrea A, Agnès C, Cécile C, Clara T, et al. UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment. Cells. 2018;7: pubmed publisher
    ..We recently demonstrated that MuRF1, an E3 ubiquitin ligase known to bind to sarcomeric proteins (telethonin, α-actin, myosins) during catabolic situations, interacts with 5 different E2 enzymes and that these E2-MuRF1 ..
  22. Vinekar A, Jayadev C, Mangalesh S, Shetty B, Vidyasagar D. Role of tele-medicine in retinopathy of prematurity screening in rural outreach centers in India - a report of 20,214 imaging sessions in the KIDROP program. Semin Fetal Neonatal Med. 2015;20:335-45 pubmed publisher
    ..The report compares other "real-world" tele-ROP programs, summarizes the impact, and provides future strategies for outreach ROP screening in middle-income ..
  23. Sebothoma B, Khoza Shangase K. A comparison between video otoscopy and standard tympanometry findings in adults living with human immunodeficiency virus (HIV) in South Africa. S Afr J Commun Disord. 2018;65:e1-e7 pubmed publisher
    ..Lastly, tele-audiologic implications of the use of video otoscopy to increase access in resource-constrained contexts are raised. ..
  24. Lawford B, Bennell K, Hinman R. Consumer Perceptions of and Willingness to Use Remotely Delivered Service Models For Exercise Management of Knee and Hip Osteoarthritis: A Cross-Sectional Survey. Arthritis Care Res (Hoboken). 2017;69:667-676 pubmed publisher
    ..regression analyses were performed to determine whether participant characteristics influenced perceptions of tele-rehabilitation. A total of 330 people spanning metropolitan, regional, and rural Australia completed the survey...
  25. Lelonge Y, Varlet F, Varela P, Saitúa F, Fourcade L, Gutiérrez R, et al. Chemocauterization with trichloroacetic acid in congenital and recurrent tracheoesophageal fistula: a minimally invasive treatment. Surg Endosc. 2016;30:1662-6 pubmed publisher
    ..Under general anesthesia, a rigid pediatric bronchoscope with a 0° rod lens telescope and tele-monitoring was used to localize the TEF...
  26. Maldonado M, Maeyama K. The metabolism of histamine in rat hypothalamus and cortex after reserpine treatment. Neurochem Int. 2015;85-86:31-9 pubmed publisher
    The effect of reserpine on histamine (HA) and tele-methylhistamine (N(Ï„)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines...
  27. Vivek C, Vikrant K. Tele-ECG and 24-hour physician support over telephone for rural doctors can help early treatment of acute myocardial infarction in rural areas. J Telemed Telecare. 2016;22:203-6 pubmed publisher
    ..We therefore planned a Tele-Electrocardiography (Tele-ECG) based pilot project in Kangra District of Himachal Pradesh in India, which was ..
  28. Larinkari S, Liisanantti J, Ala Lääkkölä T, Meriläinen M, Kyngäs H, Ala Kokko T. Identification of tele-ICU system requirements using a content validity assessment. Int J Med Inform. 2016;86:30-6 pubmed publisher
    Telemedicine in intensive care (tele-ICU) involves the use of information technologies to deliver care instructions from a command center to remote hospitals...
  29. Ward M, Ullrich F, MacKinney A, Bell A, Shipp S, Mueller K. Tele-emergency utilization: In what clinical situations is tele-emergency activated?. J Telemed Telecare. 2016;22:25-31 pubmed publisher
    b>Tele-emergency provides audio/visual communication between a central emergency care centre (tele-emergency hub) and a distant emergency department (remote ED) for real-time emergency care consultation...
  30. Kesapli M, Akyol C, Gungor F, Akyol A, Guven D, Kaya G. Inflight Emergencies During Eurasian Flights. J Travel Med. 2015;22:361-7 pubmed publisher
    ..Adding automated external defibrillator and pulse oximetry to recommended kits and training can help facilitate staff decisions such as emergency landings and tele-assistance.
  31. Pyles L, Hemmati P, Pan J, Yu X, Liu K, Wang J, et al. Initial Field Test of a Cloud-Based Cardiac Auscultation System to Determine Murmur Etiology in Rural China. Pediatr Cardiol. 2017;38:656-662 pubmed publisher
    ..They had digital heart sounds and phonocardiograms collected with the HeartLink tele auscultation system, and underwent echocardiography by a cardiology resident from the First Affiliated Hospital of ..
  32. Sockalingam S, Arena A, Serhal E, Mohri L, Alloo J, Crawford A. Building Provincial Mental Health Capacity in Primary Care: An Evaluation of a Project ECHO Mental Health Program. Acad Psychiatry. 2018;42:451-457 pubmed publisher
    ..urban-rural disparities in access to specialist care by building primary care provider (PCP) capacity through tele-education. Evidence supporting the use of this model for mental health care is limited...
  33. Bañuelos Cabrera I, Cuéllar Herrera M, Velasco A, Velasco F, Alonso Vanegas M, Carmona F, et al. Pharmacoresistant temporal lobe epilepsy modifies histamine turnover and H3 receptor function in the human hippocampus and temporal neocortex. Epilepsia. 2016;57:e76-80 pubmed publisher
    Experiments were designed to evaluate the tissue content of tele-methylhistamine (t-MeHA) and histamine as well as H3 receptor (H3 Rs) binding and activation of the heterotrimeric guanine nucleotide binding αi/o proteins (Gαi/o) ..
  34. Ravenscroft S, Pointon A, Williams A, Cross M, Sidaway J. Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues. Toxicol Sci. 2016;152:99-112 pubmed publisher
    ..of genes that encode proteins critical in cardiac Ca(2+ )handling (S100A1), sarcomere assembly (telethonin/TCAP) and β-adrenergic receptor signalling...
  35. van den Berg M, Crotty M, Liu E, Killington M, Kwakkel G, Van Wegen E. Early Supported Discharge by Caregiver-Mediated Exercises and e-Health Support After Stroke: A Proof-of-Concept Trial. Stroke. 2016;47:1885-92 pubmed publisher
    ..investigated the effects of an 8-week program of caregiver-mediated exercises commenced in hospital combined with tele-rehabilitation services on patient self-reported mobility and caregiver burden...
  36. Singh A, Dutta M, Sharma D. Unique identification code for medical fundus images using blood vessel pattern for tele-ophthalmology applications. Comput Methods Programs Biomed. 2016;135:61-75 pubmed publisher
    Identification of fundus images during transmission and storage in database for tele-ophthalmology applications is an important issue in modern era...
  37. Brennan Jones C, Eikelboom R, Bennett R, Tao K, Swanepoel D. Asynchronous interpretation of manual and automated audiometry: Agreement and reliability. J Telemed Telecare. 2016;: pubmed
    Remote interpretation of automated audiometry offers the potential to enable asynchronous tele-audiology assessment and diagnosis in areas where synchronous tele-audiometry may not be possible or practical...
  38. Kabata P, Waldman W, Sein Anand J. [Toxicological consultation data management system based on experience of Pomeranian Center of Toxicology]. Med Pr. 2015;66:635-44 pubmed publisher
    In this paper the structure of poisonings is described, based on the material collected from tele-toxicology consults by the Pomeranian Center of Toxicology in Gdańsk and harvested from its Electronic Poison Information Management ..
  39. Ambrosino N, Vitacca M, Dreher M, Isetta V, Montserrat J, Tonia T, et al. Tele-monitoring of ventilator-dependent patients: a European Respiratory Society Statement. Eur Respir J. 2016;48:648-63 pubmed publisher
    ..The need to reduce healthcare costs and to increase safety has prompted the development of tele-monitoring for home ventilatory assistance...
  40. Liu C, Scott K, Lim R, Taylor S, Calvo R. EQClinic: a platform for learning communication skills in clinical consultations. Med Educ Online. 2016;21:31801 pubmed publisher
    ..b>Tele-conference systems have been used in verbal communication skills training...
  41. Wilson S, Hair L, Hertzberg J, Kirby A, Olsen M, Lindquist J, et al. Abstinence Reinforcement Therapy (ART) for rural veterans: Methodology for an mHealth smoking cessation intervention. Contemp Clin Trials. 2016;50:157-65 pubmed publisher
    ..Reinforcement Therapy (ART) which combines evidenced based cognitive-behavioral telephone counseling (TC), a tele-medicine clinic for access to nicotine replacement (NRT), and mobile contingency management (mCM) or a control ..
  42. Merone M, Pedone C, Capasso G, Incalzi R, Soda P. A Decision Support System for Tele-Monitoring COPD-Related Worrisome Events. IEEE J Biomed Health Inform. 2017;21:296-302 pubmed publisher
    ..The experiments on data collected from 22 COPD patients tele-monitored at home for six months show that the system recognition performance is better than the one achieved by ..
  43. Møller D, Pham T, Gustafsson F, Hedley P, Ersbøll M, Bundgaard H, et al. The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy. Eur J Heart Fail. 2009;11:1031-5 pubmed publisher
  44. Rekosz J, Kasznicka M, Kwiatkowska D, Mączyńska Mazuruk R, Kołak K, Mierzejewska B, et al. Standard 12-lead electrocardiogram tele-transmission: Support in diagnosing cardiovascular diseases in operations undertaken by Warsaw-area basic medical rescue teams between 2009 and 2013. Cardiol J. 2015;22:675-82 pubmed publisher
    ..A tele-transmission and teleconsultation system (TTaTC) supports the team without a physician...
  45. Aggravi M, De Momi E, DiMeco F, Cardinale F, Casaceli G, Riva M, et al. Hand-tool-tissue interaction forces in neurosurgery for haptic rendering. Med Biol Eng Comput. 2016;54:1229-41 pubmed publisher
    Haptics provides sensory stimuli that represent the interaction with a virtual or tele-manipulated object, and it is considered a valuable navigation and manipulation tool during tele-operated surgical procedures...
  46. Pani D, Piga M, Barabino G, Crabolu M, Uras S, Mathieu A, et al. Home tele-rehabilitation for rheumatic patients: impact and satisfaction of care analysis. J Telemed Telecare. 2017;23:292-300 pubmed publisher
    Introduction In this paper, we evaluated patients' perspectives on the use of a system for home tele-rehabilitation, designed for subjects with low computer literacy suffering hand impairment due to rheumatic diseases...
  47. Gogia S, Maeder A, Mars M, Hartvigsen G, Basu A, Abbott P. Unintended Consequences of Tele Health and their Possible Solutions. Contribution of the IMIA Working Group on Telehealth. Yearb Med Inform. 2016;:41-46 pubmed
    ..Much can be done to prevent such problems, such as a need for standardization with related clinical studies for devices as well as processes used for telehealth is underlined, besides evaluation of outcomes of projects undertaken. ..
  48. Sgandurra G, Lorentzen J, Inguaggiato E, Bartalena L, Beani E, Cecchi F, et al. A randomized clinical trial in preterm infants on the effects of a home-based early intervention with the 'CareToy System'. PLoS ONE. 2017;12:e0173521 pubmed publisher
    CareToy system is an innovative tele-rehabilitative tool, useful in providing intensive, individualized, home-based, family-centred Early Intervention (EI) in infants...
  49. Ward M, Jaana M, Natafgi N. Systematic review of telemedicine applications in emergency rooms. Int J Med Inform. 2015;84:601-16 pubmed publisher
    ..applications for hospital-based emergency care, which aims to synthesize the existing evidence on the impact of tele-emergency applications that could inform future efforts and research in this area...
  50. Lejeune G, Brixtel R, Doucet A, Lucas N. Multilingual event extraction for epidemic detection. Artif Intell Med. 2015;65:131-43 pubmed publisher
    This paper presents a multilingual news surveillance system applied to tele-epidemiology...
  51. Hu D, Cheng T, Xie K, Lam R. Microengineered Conductive Elastomeric Electrodes for Long-Term Electrophysiological Measurements with Consistent Impedance under Stretch. Sensors (Basel). 2015;15:26906-20 pubmed publisher
    ..microengineered electrodes can provide a more convenient and stable bio-potential measurement platform, making tele-medical care more achievable with reduced technical barriers for instrument installation performed by patients/..
  52. Calhoun P, Datta S, Olsen M, Smith V, Moore S, Hair L, et al. Comparative Effectiveness of an Internet-Based Smoking Cessation Intervention Versus Clinic-Based Specialty Care for Veterans. J Subst Abuse Treat. 2016;69:19-27 pubmed publisher
    ..this project was to examine the effectiveness of an Internet-based smoking cessation intervention combined with a tele-health medication clinic for nicotine replacement therapy (NRT) compared to referral to clinic-based smoking ..
  53. Robertson T, Levine A, Verceles A, Buchner J, Lantry J, Papali A, et al. Remote tele-mentored ultrasound for non-physician learners using FaceTime: A feasibility study in a low-income country. J Crit Care. 2017;40:145-148 pubmed publisher
    ..We conducted a study to determine if a remote tele-intensivist could mentor geographically removed LMIC providers to obtain quality and clinically useful US images...
  54. Levine A, McCurdy M, Zubrow M, Papali A, Mallemat H, Verceles A. Tele-intensivists can instruct non-physicians to acquire high-quality ultrasound images. J Crit Care. 2015;30:871-5 pubmed publisher
    Intensive care unit telemedicine (tele-ICU) uses audiovisual systems to remotely monitor and manage patients. Intensive care unit ultrasound can augment an otherwise limited bedside evaluation...
  55. Kim C, Kang B, Choi H, Lim T, Oh J, Chee Y. Clinical application of real-time tele-ultrasonography in diagnosing pediatric acute appendicitis in the ED. Am J Emerg Med. 2015;33:1354-9 pubmed publisher
    We investigated the effectiveness of tele-mentored ultrasonography between emergency medicine (EM) residents and remote experts in diagnosing acute appendicitis...
  56. Gil Pagés M, Solana J, Sanchez Carrion R, Tormos J, Enseñat Cantallops A, García Molina A. A customized home-based computerized cognitive rehabilitation platform for patients with chronic-stage stroke: study protocol for a randomized controlled trial. Trials. 2018;19:191 pubmed publisher
    ..if chronic stroke patients with cognitive impairment could benefit from cognitive training through a customized tele-rehabilitation platform ("Guttmann, NeuroPersonalTrainer"®, GNPT®)...
  57. Udeagu C, Shah S, Toussaint M, Pickett L. Sociodemographic Differences in Clients Preferring Video-Call Over In-person Interview: A Pilot Study of HIV Tele-partner Services. AIDS Behav. 2017;21:3078-3086 pubmed publisher
    ..These results provide evidence of the potential effectiveness of video-call interviews for specific populations. ..
  58. Caffery L, Taylor M, Gole G, Smith A. Models of care in tele-ophthalmology: A scoping review. J Telemed Telecare. 2017;:1357633X17742182 pubmed publisher
    ..Synthesis of findings was performed narratively. The scoping review included 78 articles describing 62 discrete tele-ophthalmic models of care...
  59. Itoh Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Koyanagi T, et al. Titin mutations as the molecular basis for dilated cardiomyopathy. Biochem Biophys Res Commun. 2002;291:385-93 pubmed
    ..were found in the Z-line region of titin and decreased binding affinities of titin to Z-line proteins T-cap/telethonin and alpha-actinin, respectively, in yeast two-hybrid assays...
  60. Mazzone A, Strege P, Tester D, Bernard C, Faulkner G, De Giorgio R, et al. A mutation in telethonin alters Nav1.5 function. J Biol Chem. 2008;283:16537-44 pubmed publisher
    ..A 42-year-old male patient was found to have a mutation in the gene TCAP, encoding for the small protein telethonin. Telethonin was found to be expressed in the human gastrointestinal smooth muscle, co-localized with Na(v)1...
  61. Hershberger R, Parks S, Kushner J, Li D, Ludwigsen S, Jakobs P, et al. Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy. Clin Transl Sci. 2008;1:21-6 pubmed publisher
    ..0%) with three titin-cap or telethonin (TCAP) mutations, three probands (1.0%) with two LIM domain binding 3 (LDB3) mutations, and one proband (0...
  62. Hirtle Lewis M, Desbiens K, Ruel I, Rudzicz N, Genest J, Engert J, et al. The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN. Clin Cardiol. 2013;36:628-33 pubmed publisher
    ..Despite high locus and allele heterogeneity, we demonstrate that a prioritized gene study, combined with next-generation exome-sequencing data, can be fruitful for the identification of DCM mutations. ..
  63. Van Oosterhout J, Heemskerk C, de Baar M, van der Helm F, Abbink D. Tele-manipulation With Two Asymmetric Slaves: Two Operators Perform Better Than One. IEEE Trans Haptics. 2017;: pubmed publisher
    Certain tele-manipulation tasks require manipulation by two asymmetric slaves, for example a crane for hoisting and a dexterous robotic arm for fine manipulation...
  64. Cornelis N, Buys R, Fourneau I, Dewit T, Cornelissen V. Exploring physical activity behaviour - needs for and interest in a technology-delivered, home-based exercise programme among patients with intermittent claudication. Vasa. 2017;:1-9 pubmed publisher
    ..Home-based exercise seems an appealing alternative; especially since technological advances, such as tele-coaching and tele-monitoring, may facilitate the process and support patients when adopting a physically active ..
  65. Katoh M, Katoh M. Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon. Int J Oncol. 2004;24:757-63 pubmed
    ..The evolutionary recombination hotspot and oncogenomic recombination hotspot might be clustered around the fragile sites within the human genome. ..
  66. Torres Zenteno A, Fernandez F, Palomino García A, Moniche F, Escudero I, Jiménez Hernández M, et al. Mobile platform for treatment of stroke: A case study of tele-assistance. Health Informatics J. 2016;22:676-90 pubmed publisher
    This article presents the technological solution of a tele-assistance process for stroke patients in acute phase in the Seville metropolitan area...
  67. Renn B, Arean P. Psychosocial Treatment Options for Major Depressive Disorder in Older Adults. Curr Treat Options Psychiatry. 2017;4:1-12 pubmed publisher
    ..b>Tele-mental health represents one such exciting new way of improving access and uptake of treatment by older adults...
  68. He H, Hu Z, Tserennadmid S, Chen S, Liu X. Novel Muscle-Specific Genes TCAP, TNNI1, and FHL1 in Cattle: SNVs, Linkage Disequilibrium, Combined Genotypes, Association Analysis of Growth Performance, and Carcass Quality Traits and Expression Studies. Anim Biotechnol. 2017;:1-10 pubmed publisher
    ..These data support the high potentials of the TCAP, TNNI1, and FHL1 as marker genes to improve the growth performance and carcass quality traits of Qinchuan cattle or other animals selection programs...
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    The tele-ICU is designed to leverage, not replace, the need for bedside clinical expertise in the diagnosis, treatment, and assessment of various critical illnesses...
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    ..Compared with traditional Sanger-based sequencing, test cost and turn around time were reduced by approximately 50%. The DCM CardioChip is a highly efficient screening test with a projected clinical sensitivity of 26-29%. ..
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    Telemedicine can be used for education as well as clinical care. Wearable platforms now allow a remote student to "tele-present" cases to "Tele-Attending" elsewhere in real time...
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    Mutations of the human telethonin gene have recently been shown to cause limb girdle muscular dystrophy type 2G in three Brazilian families...
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    ..study, we analyzed the feasibility and early results of a perioperative, video-based educational program and tele-health home monitoring model on postoperative care management and readmissions for patients undergoing liver ..
  75. Panlaqui O, Broadfield E, Champion R, Edington J, Kennedy S. Outcomes of telemedicine intervention in a regional intensive care unit: a before and after study. Anaesth Intensive Care. 2017;45:605-610 pubmed
    ..means that critically ill patients in our regional centre can continue to receive specialist care remotely through tele-ICU consultations thus avoiding the need for patient transport...
  76. Ni M, Brown L, Lawler D, Ellis T, Deangelis T, Latham N, et al. The rehabilitation enhancing aging through connected health (REACH) study: study protocol for a quasi-experimental clinical trial. BMC Geriatr. 2017;17:221 pubmed publisher
    ..of this study is to evaluate the preliminary effectiveness of a physical therapy program, augmented with mobile tele-health technology, on mobility function and healthcare utilization among older adults...
  77. Groft S, Posada de la Paz M. Preparing for the Future of Rare Diseases. Adv Exp Med Biol. 2017;1031:641-648 pubmed publisher
    ..b>Tele Health and Tele Medicine may provide the necessary access to expert clinicians with a better understanding of ..
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    ..We demonstrate that Siva specifically interacts with the heart and skeletal muscle protein telethonin. The expression of Siva is increased in heart tissue of CVB3-infected mice and the proteins colocalize in ..
  79. Anczykowski J, Willems S, Hoffmann B, Meinertz T, Blankenberg S, Patten M. Early Detection of Symptomatic Paroxysmal Cardiac Arrhythmias by Trans-Telephonic ECG Monitoring: Impact on Diagnosis and Treatment of Atrial Fibrillation. J Cardiovasc Electrophysiol. 2016;27:1032-7 pubmed publisher
    ..patients' treatment and outcome, we investigated, whether self-guided, trans-telephonic event-recorder monitoring (Tele-ECG) improves diagnosis and influences treatment options...
  80. Yin H, Douglas G, Cai Y, Liu C, Copetti D. Remediation of internal phosphorus loads with modified clays, influence of fluvial suspended particulate matter and response of the benthic macroinvertebrate community. Sci Total Environ. 2018;610-611:101-110 pubmed publisher
    ..This study indicates that to sustain a low P flux across the sediment-water interface in shallow, turbid lakes, repeat dosing of geoengineering materials, temporally aligned to the deposition of fluvial SPM, may be required. ..
  81. Akhigbe T, Zolnourian A, Bulters D. Mentoring models in neurosurgical training: Review of literature. J Clin Neurosci. 2017;45:40-43 pubmed publisher
    ..Language, all of them described mentoring model used including simulation, distance, collaborative, facilitative tele-mentoring and peer mentoring...
  82. Sarfo F, Adamu S, Awuah D, Sarfo Kantanka O, Ovbiagele B. Potential role of tele-rehabilitation to address barriers to implementation of physical therapy among West African stroke survivors: A cross-sectional survey. J Neurol Sci. 2017;381:203-208 pubmed publisher
    ..b>Tele-rehabilitation could be a viable avenue to address unmet rehabilitation needs in LMICs...
  83. Ferrer J, Chaumont T, Trujillo L, Fernandez I, Guerrero J, Stewart P, et al. New tele-diagnostic model using volume sweep imaging for rural areas. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:2622-2625 pubmed publisher
    ..This paper implements a new model for tele-ultrasound (US) based on volumetric sweep imaging protocols specially designed for the acquisition of US...
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    ..sensor, which do not require any manual intervention or expert guidance, is cost effective and hence are ideal for tele rehabilitation purpose. Stability analysis is done during Single Limb Stance (SLS) exercise...
  85. Francis A, Sunitha B, Vinodh K, Polavarapu K, Katkam S, Modi S, et al. Novel TCAP mutation c.32C>A causing limb girdle muscular dystrophy 2G. PLoS ONE. 2014;9:e102763 pubmed publisher
    TCAP encoded telethonin is a 19 kDa protein, which plays an important role in anchoring titin in Z disc of the sarcomere, and is known to cause LGMD2G, a rare muscle disorder characterised by proximal and distal lower limb weakness, calf ..
  86. Crundall Goode A, Goode K, Clark A. What impact do anxiety, depression, perceived control and technology capability have on whether patients with chronic heart failure take-up or continue to use home tele-monitoring services? Study design of ADaPT-HF. Eur J Cardiovasc Nurs. 2017;16:283-289 pubmed publisher
    Home tele-monitoring (HTM) is used to monitor the clinical signs and symptoms of patients with chronic heart failure (CHF) in order to reduce unplanned hospital admissions...
  87. Moffet H, Tousignant M, Nadeau S, Mérette C, Boissy P, Corriveau H, et al. Patient Satisfaction with In-Home Telerehabilitation After Total Knee Arthroplasty: Results from a Randomized Controlled Trial. Telemed J E Health. 2017;23:80-87 pubmed publisher
    ..This study aims to compare satisfaction level of patients following in-home telerehabilitation (TELE) after TKA to one of the patients following a usual face-to-face home visit (STD) rehabilitation...
  88. Aguas M, Del Hoyo J, Faubel R, Valdivieso B, Nos P. Telemedicine in the treatment of patients with inflammatory bowel disease. Gastroenterol Hepatol. 2017;40:641-647 pubmed publisher
    ..Telemedicine and its various applications (telemanagement, teleconsulting and tele-education) enable closer follow-up and provide education resources that promote patient empowerment, encouraging ..
  89. Tan H, Su W, Wang P, Zhang W, Sattler M, Zou P. Expression and purification of a difficult sarcomeric protein: Telethonin. Protein Expr Purif. 2017;140:74-80 pubmed publisher
    b>Telethonin anchors the N-terminal region of titin in the Z-disk of the sarcomere by binding to two immunoglobulin-like (Ig) domains (Z1 and Z2) of titin (Z1Z2)...
  90. Muñoz P, Micó G, Bru L, PASTOR D, Pérez D, Doménech J, et al. Silicon Nitride Photonic Integration Platforms for Visible, Near-Infrared and Mid-Infrared Applications. Sensors (Basel). 2017;17: pubmed publisher
    ..photonics is on the rise owing to the broadband nature of the material, allowing applications of biophotonics, tele/datacom, optical signal processing and sensing, from visible, through near to mid-infrared wavelengths...
  91. Moon B, Yu S, Ko S, Park S, Paik J. Continuous digital zooming using local self-similarity-based super-resolution for an asymmetric dual camera system. J Opt Soc Am A Opt Image Sci Vis. 2017;34:991-1003 pubmed publisher
    ..zooming method using a super-resolution (SR) algorithm based on the local self-similarity between the wide- and tele-view images acquired by an asymmetric dual camera system...