Gene Symbol: TEAD4
Description: TEA domain transcription factor 4
Alias: EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B, transcriptional enhancer factor TEF-3, TEA domain family member 4, related transcription enhancer factor 1B, transcription factor 13-like 1, transcription factor RTEF-1, transcriptional enhancer factor 1-related, transcriptional enhancer factor 3
Species: human
Products:     TEAD4

Top Publications

  1. Zhang H, Liu C, Zha Z, Zhao B, Yao J, Zhao S, et al. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009;284:13355-62 pubmed publisher
    ..Our study establishes a functional partnership between TAZ and TEAD under negative regulation by the Hippo signaling pathway. ..
  2. Xu M, Jin Y, Song Q, Wu J, Philbrick M, Cully B, et al. The endothelium-dependent effect of RTEF-1 in pressure overload cardiac hypertrophy: role of VEGF-B. Cardiovasc Res. 2011;90:325-34 pubmed publisher
    ..These results suggest that the RTEF-1-driven increase of VEGF-B plays an important role in communication between the endothelium and myocardium. ..
  3. Messmer Blust A, Zhang C, Shie J, Song Q, He P, Lubenec I, et al. Related transcriptional enhancer factor 1 increases endothelial-dependent microvascular relaxation and proliferation. J Vasc Res. 2012;49:249-59 pubmed publisher
    ..Understanding the effect of RTEF-1 in microvessel relaxation may provide beneficial knowledge in improving treatments in regards to ischemic vascular disorders. ..
  4. Stewart A, Richard C, Suzow J, Stephan D, Weremowicz S, Morton C, et al. Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family. Genomics. 1996;37:68-76 pubmed
    ..Phylogenetic analysis of all known TEF-1-related proteins identified human RTEF-1 as one of four vertebrate members of this multigene family and further suggests that these genes diverged in the earliest metazoan ancestors. ..
  5. Vassilev A, Kaneko K, Shu H, Zhao Y, DePamphilis M. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 2001;15:1229-41 pubmed
    ..Because TEAD-dependent transcription was limited by YAP65, and YAP65 also binds Src/Yes protein tyrosine kinases, we propose that YAP65 regulates TEAD-dependent transcription in response to mitogenic signals. ..
  6. Appukuttan B, McFarland T, Davies M, Atchaneeyasakul L, Zhang Y, Babra B, et al. Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina. Invest Ophthalmol Vis Sci. 2007;48:3775-82 pubmed
    ..Alternative spliced variants of human RTEF-1 transcripts are able to potentiate expression from the VEGF 5' proximal promoter region. ..
  7. Zhao B, Ye X, Yu J, Li L, Li W, Li S, et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008;22:1962-71 pubmed publisher
    ..Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP. ..
  8. Jin Y, Wu J, Song X, Song Q, Cully B, Messmer Blust A, et al. RTEF-1, an upstream gene of hypoxia-inducible factor-1?, accelerates recovery from ischemia. J Biol Chem. 2011;286:22699-705 pubmed publisher
    ..These results identify RTEF-1 as a regulator of HIF-1? transcription, which results in up-regulation of HIF-1? and acceleration of recovery from ischemia. ..
  9. An X, Jin Y, Philbrick M, Wu J, Messmer Blust A, Song X, et al. Endothelial cells require related transcription enhancer factor-1 for cell-cell connections through the induction of gap junction proteins. Arterioscler Thromb Vasc Biol. 2012;32:1951-9 pubmed publisher
    ..These findings provide novel insights into the transcriptional control of endothelial function in the coordination of cell-cell connections. ..

More Information

Publications104 found, 100 shown here

  1. Akizawa H, Yanagawa Y, Nagano M, Bai H, Takahashi M, Kawahara M. Significance of CCN2 expression in bovine preimplantation development. Anim Sci J. 2019;90:49-54 pubmed publisher
    ..We previously showed that the reciprocal regulation of CCN2 and TEAD4 is required for proper TE differentiation in bovine blastocysts; however, the function of CCN2 during early ..
  2. Hwang J, Kim A, Kim K, Il Park J, Oh H, Moon S, et al. TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression. Nat Commun. 2019;10:421 pubmed publisher
    ..TAZ physically interacts with c-Jun and Tead4 to induce Irs1 transcription. Finally, statin administration decreases TAZ, IRS1 level and insulin sensitivity...
  3. Kim E, Ahn B, Oh H, Lee Y, Lee J, Lee Y, et al. High Yes-associated protein 1 with concomitant negative LATS1/2 expression is associated with poor prognosis of advanced gastric cancer. Pathology. 2019;: pubmed publisher
    ..LATS1/2 (large tumour suppressor homolog 1 and 2), YAP1 (Yes-associated protein 1), and TEAD4 (TEA domain-containing sequence-specific transcription factors 4) are core components of the Hippo pathway, and ..
  4. Park B, Chang S, Lee G, Kang B, Kim J, Park H. Wnt3a disrupts GR-TEAD4-PPARγ2 positive circuits and cytoskeletal rearrangement in a β-catenin-dependent manner during early adipogenesis. Cell Death Dis. 2019;10:16 pubmed publisher
    ..Our findings that TEAD4 requires GR for its expression and for the ability to bind its own promoter and the hotspot region of Pparg2 gene ..
  5. Weiler S. [YAP induces chromosomal instability in liver cancer patients]. Pathologe. 2018;39:185-188 pubmed publisher
    ..HCC tissue microarrays were analyzed using immunohistochemistry. Together with the transcription factors TEAD4 and FOXM1, YAP induces the expression of genes which are responsible for the development of chromosomal ..
  6. Zhang W, Xu J, Li J, Guo T, Jiang D, Feng X, et al. The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex. J Biol Chem. 2018;293:17119-17134 pubmed publisher
    ..Interestingly, we found that the TEAD4 knockdown-mediated adipogenesis proceeded in a Yes-associated protein (YAP)/TAZ (Wwtr1)-independent manner and ..
  7. Kim K, Seibert J, Edea Z, Graves K, Kim E, Keating A, et al. Characterization of the acute heat stress response in gilts: III. Genome-wide association studies of thermotolerance traits in pigs. J Anim Sci. 2018;96:2074-2085 pubmed publisher
    ..The other important candidate genes associated with ΔRR (PAIP1, NNT, and TEAD4), ΔTR (LIMS2, TTR, and TEAD4), and ΔTS (ERBB4, FKBP1B, NFATC2, and ATP9A) have reported roles in the cellular ..
  8. Bum Erdene K, Zhou D, Gonzalez Gutierrez G, Ghozayel M, Si Y, Xu D, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chem Biol. 2019;26:378-389.e13 pubmed publisher
    ..Yap1 tightly binds to TEAD4 via a large flat interface, making the development of small-molecule orthosteric inhibitors highly challenging...
  9. Tome Garcia J, Erfani P, Nudelman G, Tsankov A, Katsyv I, Tejero R, et al. Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Nat Commun. 2018;9:4020 pubmed publisher
    ..To further characterize TEAD's functional role in GBM, we knockout TEAD1 or TEAD4 in patient-derived GBM lines using CRISPR-Cas9...
  10. Suasnavas E, Heywood S, Ward A, Cox L, O Grady M, Zhao Y, et al. Isolation and characterization of trophoblast-derived stem-like cells from peri-implantation porcine embryos. Anim Reprod Sci. 2015;154:128-41 pubmed publisher
    ..the presence (and relative abundance) of mRNA transcripts from genes involved in trophoblast function (CDX2, TEAD4, CYP17A1, HSD17B1, FGFR2, PLET, HAND1) as well as some genes known to mediate pluripotency (POU5F1, KLF4, CMYC)...
  11. Jiao S, Li C, Hao Q, Miao H, Zhang L, Li L, et al. VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nat Commun. 2017;8:14058 pubmed publisher
    ..Mechanistically, TEAD4 associates with TCF4 to form a complex and cobind target genes...
  12. Kumar R, Ray S, Home P, Saha B, Bhattacharya B, Wilkins H, et al. Regulation of energy metabolism during early mammalian development: TEAD4 controls mitochondrial transcription. Development. 2018;145: pubmed publisher
    ..Here, we show that conserved transcription factor TEAD4, which is essential for pre-implantation mammalian development, regulates this process by promoting mitochondrial ..
  13. Watanabe Y, Miyasaka K, Kubo A, Kida Y, Nakagawa O, Hirate Y, et al. Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Sci Rep. 2017;7:46135 pubmed publisher
    ..die at the preimplantation stage without forming a blastocoel, and Cdx2 is not turned on even though both Yap and Tead4 reside normally in nuclei...
  14. Cheng X, Xu S, Song C, He L, Lian X, Liu Y, et al. Roles of ER? during mouse trophectoderm lineage differentiation: revealed by antagonist and agonist of ER?. Dev Growth Differ. 2016;58:327-38 pubmed publisher
    ..Moreover, after MPP treatment, the expression levels of the genes related to TE specification, Tead4, Gata3 and Cdx2, were significantly reduced...
  15. Haider S, Meinhardt G, Saleh L, Fiala C, Pollheimer J, Knöfler M. Notch1 controls development of the extravillous trophoblast lineage in the human placenta. Proc Natl Acad Sci U S A. 2016;113:E7710-E7719 pubmed
    ..In contrast, Notch1 repressed syncytialization and expression of TEAD4 and p63, two regulators controlling self-renewal of villous cytotrophoblasts...
  16. Zhong B, Bian L, Wang G, Zhou Y, Chen Y, Peng F. Identification of key genes involved in HER2-positive breast cancer. Eur Rev Med Pharmacol Sci. 2016;20:664-72 pubmed
    ..g. TCONS_00003876-EGR1, TCONS_00003876-FOS, lnc-HOXC4-3:1-FOS, lnc-HOXC4-3:1-BCL6B, lnc-TEAD4-1:1-FOS and lnc-TEAD4-1:1-BCL6B), meanwhile, co-expressed DEGs of TCONS_00003876, lnc-HOXC4-3:1 and lnc-TEAD4-1:1 ..
  17. Joshi S, Davidson G, Le Gras S, Watanabe S, Braun T, Mengus G, et al. TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo. PLoS Genet. 2017;13:e1006600 pubmed publisher
    ..We show that silencing of either Tead1, Tead2 or Tead4 did not effect primary myoblast (PM) differentiation, but that their simultaneous knockdown strongly impaired ..
  18. Alsalim H, Jafarpour F, Ghazvini Zadegan F, Nasr Esfahani M, Niasari Naslaji A. Epigenotoxic Effect of Dimethyl Sulfoxide on Buffalo Somatic Cells and Buffalo-Bovine Interspecies Somatic Cell Nuclear Transfer Embryos. Cell J. 2019;20:544-551 pubmed publisher
    ..blastocyst rates and gene expression (pluripotent genes: OCT4, NANOG, SOX2, and trophectodermal genes: CDX2 and TEAD4) of produced blastocysts...
  19. Hayashi S, Ochi H, Ogino H, Kawasumi A, Kamei Y, Tamura K, et al. Transcriptional regulators in the Hippo signaling pathway control organ growth in Xenopus tadpole tail regeneration. Dev Biol. 2014;396:31-41 pubmed publisher
    ..regulators during Xenopus tadpole tail regeneration by overexpressing a dominant-negative form of Yap (dnYap) or Tead4 (dnTead4) under a heat-shock promoter in transgenic animal lines...
  20. Li Y, Liu S, Ng E, Li R, Poulsen A, Hill J, et al. Structural and ligand-binding analysis of the YAP-binding domain of transcription factor TEAD4. Biochem J. 2018;475:2043-2055 pubmed publisher
    ..using NMR spectroscopy, we validated compounds that bind to these pockets and also identify the residues in mouse TEAD4 (mTEAD4) that interact with these compounds...
  21. Liu Y, Wang G, Liang Z, Mei Z, Wu T, Cui A, et al. Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis. Thorac Cancer. 2018;9:785-793 pubmed publisher
    ..Regulation of LOX by YAP and TEAD4 was explored by YAP or TEAD4 short hairpin RNA interference in a LoVo cell line...
  22. Górnikiewicz B, Ronowicz A, Krzemiński M, Sachadyn P. Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential. BMC Genomics. 2016;17:231 pubmed publisher
    ..enriched with a number of transcription factors binding motifs including those of Mfsd6l, Mef2c, Meis3, Tead4, and Runx1...
  23. Wang E, Cheng J, Thakur A, Yi Y, Tsai S, Hoodless P. YAP transcriptionally regulates ErbB2 to promote liver cell proliferation. Biochim Biophys Acta Gene Regul Mech. 2018;: pubmed publisher
    ..Analysis of ChIP-seq data revealed enrichment of the transcription factor TEAD4 at the ERBB2 promoter...
  24. Akizawa H, Kobayashi K, Bai H, Takahashi M, Kagawa S, Nagatomo H, et al. Reciprocal regulation of TEAD4 and CCN2 for the trophectoderm development of the bovine blastocyst. Reproduction. 2018;155:563-571 pubmed publisher
    ..TEA domain transcription factor 4 (TEAD4) is a well-known regulator to determine TE properties of blastomeres in rodent models...
  25. Hong Y, Hong K, Byun S, Choi H, Do J. Reprogramming of extraembryonic trophoblast stem cells into embryonic pluripotent state by fusion with Embryonic Stem Cells. Stem Cells Dev. 2018;: pubmed publisher
    ..They expressed the pluripotency markers Oct4 and Nanog, whereas the expression of Cdx2 and Tead4, trophoblast lineage markers, was diminished...
  26. Weiler S, Pinna F, Wolf T, Lutz T, Geldiyev A, Sticht C, et al. Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer. Gastroenterology. 2017;152:2037-2051.e22 pubmed publisher
    ..box M1 [FOXM1]) or verteporfin (inhibitor of the interaction between YAP and TEA domain transcription factor 4 [TEAD4]). We performed co-immunoprecipitation and chromatin immunoprecipitation experiments...
  27. Qi Y, Yu J, Han W, Fan X, Qian H, Wei H, et al. A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferation. Nat Commun. 2016;7:ncomms11840 pubmed publisher
    ..We show that TEAD4, the transcription factor that mediates Hippo-YAP signalling, undergoes alternative splicing facilitated by the ..
  28. Droog M, Nevedomskaya E, Kim Y, Severson T, Flach K, Opdam M, et al. Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas. Cancer Res. 2016;76:3773-84 pubmed publisher
    ..network involving ERα and FOXA1 together with the enhancer-enriched transcriptional regulators p300, FOXM1, TEAD4, FNFIC, CEBP8, and TCF12...
  29. Kaan H, Chan S, Tan S, Guo F, Lim C, Hong W, et al. Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex. Sci Rep. 2017;7:2035 pubmed publisher
    ..Herein, we report the crystal structure of TAZ-TEAD4 complex, which reveals two binding modes. The first is similar to the published YAP-TEAD structure...
  30. Rajbhandari P, Lopez G, Capdevila C, Salvatori B, Yu J, Rodríguez Barrueco R, et al. Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. Cancer Discov. 2018;8:582-599 pubmed publisher
    ..A 10-protein transcriptional module-centered around a TEAD4-MYCN positive feedback loop-emerged as the regulatory driver of the high-risk subtype associated with MYCN ..
  31. Reinholt B, Bradley J, Jacobs R, Ealy A, Johnson S. Tissue organization alters gene expression in equine induced trophectoderm cells. Gen Comp Endocrinol. 2017;247:174-182 pubmed publisher
    ..Conformation did not affect expression of CDX2, POU5F1, TEAD4, ETS2, ELF3, GATA2 or TFAP2A, the core gene network of native TE...
  32. Man Q, Ma Y, Liu J, Zhao Y, Liu B, Zhao Y. Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior. Biomed Res Int. 2017;2017:4624890 pubmed publisher
    ..Importantly, the mRNA levels of transcription factors (TEAD1, TEAD4, and RUNX2) and cell cycle related genes (CDK2, PCNA), which interact with the transcriptional coactivators YAP/..
  33. O Driscoll C, Coulter J, Bressler J. Induction of a trophoblast-like phenotype by hydralazine in the p19 embryonic carcinoma cell line. Biochim Biophys Acta. 2013;1833:460-7 pubmed publisher
    ..trophoblast-like properties included the intermediary filament Troma-1/cytokeratin 8 and the transcription factor Tead4. A decrease in CpG methylation at three sites in the TEAD4 promoter and the B1 repeated sequence was observed...
  34. Troilo A, Benson E, Esposito D, Garibsingh R, Reddy E, Mungamuri S, et al. Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations. Oncotarget. 2016;7:28765-82 pubmed publisher
    ..tumor cells exhibiting high constitutive TEAD transcriptional activity was markedly inhibited by dominant negative TEAD4, which did not inhibit the growth of Hippo wild-type cells with low levels of regulatable TEAD-mediated ..
  35. Li W, Dong S, Wei W, Wang G, Zhang A, Pu P, et al. The role of transcriptional coactivator TAZ in gliomas. Oncotarget. 2016;7:82686-82699 pubmed publisher
    ..Using Co-immunoprecipitation TAZ was identified to bind to TEAD4. Therefore, our findings indicate that TAZ is overexpressed in glioma and translocated more into nucleus in high ..
  36. Sakurai N, Takahashi K, Emura N, Hashizume T, Sawai K. Effects of downregulating TEAD4 transcripts by RNA interference on early development of bovine embryos. J Reprod Dev. 2017;63:135-142 pubmed publisher
    Transcription factor TEA domain family transcription factor 4 (Tead4) is one of the key factors involved in the differentiation of the trophectoderm (TE) in murine embryos...
  37. Hou D, Su M, Li X, Li Z, Yun T, Zhao Y, et al. The Efficient Derivation of Trophoblast Cells from Porcine In Vitro Fertilized and Parthenogenetic Blastocysts and Culture with ROCK Inhibitor Y-27632. PLoS ONE. 2015;10:e0142442 pubmed publisher
    ..The expression of TR lineage markers, such as CDX2, KRT7, KRT18, TEAD4, ELF5 and HAND1, imprinted genes such as IGF2, PEG1 and PEG10, and telomerase activity related genes TERC and ..
  38. Jang J, Kim M, Lee Y, Lee J, Kim D, Song S, et al. RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3. Oncogene. 2017;36:999-1011 pubmed publisher
    ..using mammalian homologs reveled that LATS1/2-mediated YAP phosphorylation-facilitated dissociation of the YAP-TEAD4 complex and association of the YAP-RUNX3 complex...
  39. Alarcon V. Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo. Biol Reprod. 2010;83:347-58 pubmed publisher
    ..Pard6b knockdown also diminished the expression of CDX2, a TE-lineage transcription factor, in the outer cells. TEAD4, a transcriptional activator that is required for Cdx2 expression and cavity formation, was not essential for the ..
  40. Sun C, De Mello V, Mohamed A, Ortuste Quiroga H, Garcia Munoz A, Al Bloshi A, et al. Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function. Stem Cells. 2017;35:1958-1972 pubmed publisher
    ..Finally, TAZ operates through Tead4 to enhance myogenic differentiation...
  41. Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, et al. Targeting IRF3 as a YAP agonist therapy against gastric cancer. J Exp Med. 2018;215:699-718 pubmed publisher
    ..IRF3 interacts with both YAP and TEAD4 in the nucleus to enhance their interaction, promoting nuclear translocation and activation of YAP...
  42. Kang W, Huang T, Zhou Y, Zhang J, Lung R, Tong J, et al. miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis. Cell Death Dis. 2018;9:92 pubmed publisher
    ..The regulation of YAP1, TEAD4, and CTGF expression by miR-375 was evaluated by qRT-PCR, western blot, and luciferase reporter assays, ..
  43. Emura N, Sakurai N, Takahashi K, Hashizume T, Sawai K. OCT-4 expression is essential for the segregation of trophectoderm lineages in porcine preimplantation embryos. J Reprod Dev. 2016;62:401-8 pubmed publisher
    ..Real-time RT-PCR analysis revealed no difference in the levels of SOX2, TEAD4, FGF4 and FGFR1-IIIc, all of which are known to be regulated by OCT-4, between the OCT-4-siRNA-injected morulae ..
  44. Ma Y, Liu Y, Pan J. Verteporfin induces apoptosis and eliminates cancer stem-like cells in uveal melanoma in the absence of light activation. Am J Cancer Res. 2016;6:2816-2830 pubmed
    ..We found that verteporfin disrupted the interaction between YAP and TEAD4 in UM cells and decreased the expression of YAP targeted downstream genes...
  45. Soncin F, Khater M, To C, Pizzo D, Farah O, Wakeland A, et al. Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development. Development. 2018;145: pubmed publisher
    ..a human-specific marker of proliferative cytotrophoblast, where it is co-expressed with the transcription factor TEAD4. As TEAD4 is involved in trophectoderm specification in the mouse, we posit a regulatory role for VGLL1 in early ..
  46. Jacquemin P, Depetris D, Mattei M, Martial J, Davidson I. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. Genomics. 1999;55:127-9 pubmed
  47. Vaudin P, Delanoue R, Davidson I, Silber J, Zider A. TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation. Development. 1999;126:4807-16 pubmed
    ..Expression of TDU in Drosophila by means of the UAS-GAL4 system shows that this human protein can substitute for Vg in wing formation. We propose that TDU is a specific coactivator for the mammalian TEFs. ..
  48. Jung D, Park S, Kim K, Kim C, Song S. CG200745, an HDAC inhibitor, induces anti-tumour effects in cholangiocarcinoma cell lines via miRNAs targeting the Hippo pathway. Sci Rep. 2017;7:10921 pubmed publisher
    ..This was accompanied by downregulation of YAP, TEAD4, TGF-β2, SMAD3, NOTCH3, HES5, Axl, and Gas6 and upregulation of the miRNAs miR-22-3p, miR-22-5p, miR-194-5p, miR-..
  49. Mesrouze Y, Meyerhofer M, Bokhovchuk F, Fontana P, Zimmermann C, Martin T, et al. Effect of the acylation of TEAD4 on its interaction with co-activators YAP and TAZ. Protein Sci. 2017;26:2399-2409 pubmed publisher
    ..In this report we have studied the effect of TEAD4 acylation on its interaction with YAP and the other co-activator transcriptional co-activator with PDZ-binding ..
  50. Karasseva N, Tsika G, Ji J, Zhang A, Mao X, Tsika R. Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions. Mol Cell Biol. 2003;23:5143-64 pubmed
  51. Liu X, Zhao D, James L, Li J, Zeng H. Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor. FASEB J. 2011;25:1188-97 pubmed publisher
    Transcription enhancer factor 3 (TEF3) is known to regulate the expression of muscle-specific genes and to play important roles in muscle development and diseases...
  52. Meng J, Tang H, Zhou K, Shen W, Guo H. TFF3 and survivin expressions associate with a lower survival rate in gastric cancer. Clin Exp Med. 2013;13:297-303 pubmed publisher
    ..Patients with gastric cancer can increase the survival rate through an earlier diagnosis and appropriate treatment. ..
  53. Yuan H, Liu H, Liu Z, Zhu D, Amos C, Fang S, et al. Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival. Int J Cancer. 2015;137:638-45 pubmed publisher
    ..e., MST1, MST2, SAV1, LATS1, LATS2, MOB1A, MOB1B, YAP1, TEAD1, TEAD2, TEAD3 and TEAD4) from the dataset of our previously published CM genome-wide association study and comprehensively analyzed their ..
  54. Valencia Sama I, Zhao Y, Lai D, Janse van Rensburg H, Hao Y, Yang X. Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor. J Biol Chem. 2015;290:16906-17 pubmed publisher
    ..Altogether, this study provides novel evidence that the Hippo component TAZ can function as a co-repressor and regulate biological functions by negatively regulating downstream cellular genes. ..
  55. Pobbati A, Han X, Hung A, Weiguang S, Huda N, Chen G, et al. Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure. 2015;23:2076-86 pubmed publisher
    ..Therefore, our studies discover a novel way of targeting TEAD transcription factors and set the stage for therapeutic development of specific TEAD-YAP inhibitors against human cancers. ..
  56. Lin K, Moroishi T, Meng Z, Jeong H, Plouffe S, Sekido Y, et al. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017;19:996-1002 pubmed publisher
    ..Our data reveal a mechanism governing TEAD nucleocytoplasmic shuttling and show that TEAD localization is a critical determinant of Hippo signalling output. ..
  57. Tsuchida C, Sakuramoto Tsuchida S, Taked M, Itaya Hironaka A, Yamauchi A, Misu M, et al. Expression of REG family genes in human inflammatory bowel diseases and its regulation. Biochem Biophys Rep. 2017;12:198-205 pubmed publisher
    ..The promoters contain consensus transcription factor binding sequences for MZF1, RTEF1/TEAD4, and STAT3 in REG I?, and HLTF/FOXN2F in REG I?, respectively...
  58. Liu X, Zhao D, Qin L, Li J, Zeng H. Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells. J Biol Chem. 2008;283:34159-67 pubmed publisher
    ..We further showed that knockdown of TEF3, not other members of TEF family inhibited VEGF-A(165)-induced DSCR1-1L expression...
  59. Liu Y, Wang G, Yang Y, Mei Z, Liang Z, Cui A, et al. Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner. Oncogene. 2016;35:2789-800 pubmed publisher
    ..pathway dysregulation in tumor development and progression, we investigated its downstream transcription factor TEAD4 in colorectal cancer (CRC)...
  60. Obier N, Cauchy P, Assi S, Gilmour J, Lie A Ling M, Lichtinger M, et al. Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate. Development. 2016;143:4324-4340 pubmed
    ..Furthermore, AP-1 is required for de novo binding of TEAD4, a transcription factor connected to Hippo signalling...
  61. Hsu D, Guo Y, Alberts G, Copeland N, Gilbert D, Jenkins N, et al. Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation. J Biol Chem. 1996;271:13786-95 pubmed
    ..These results indicate that increased expression of a TEF-1-related protein may be important for both mitogen-stimulated fibroblast proliferation and skeletal muscle cell differentiation. ..
  62. Jacquemin P, Hwang J, Martial J, Dolle P, Davidson I. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. J Biol Chem. 1996;271:21775-85 pubmed
    ..These observations suggest additional roles for the TEF proteins in central nervous system development and organogenesis. ..
  63. Chan S, Lim C, Huang C, Chong Y, Gunaratne H, Hogue K, et al. WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ. Oncogene. 2011;30:600-10 pubmed publisher
    ..These results suggest that the WW domain-mediated interaction with Wbp2 promotes the transforming ability of TAZ. ..
  64. Appukuttan B, McFarland T, Stempel A, Kassem J, Hartzell M, Zhang Y, et al. The related transcriptional enhancer factor-1 isoform, TEAD4(216), can repress vascular endothelial growth factor expression in mammalian cells. PLoS ONE. 2012;7:e31260 pubmed publisher
    ..We have previously shown that isoforms of the transcriptional enhancer factor 1-related (TEAD4) protein can enhance the production of VEGF...
  65. Luca G, Haba Rubio J, Dauvilliers Y, Lammers G, Overeem S, Donjacour C, et al. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. J Sleep Res. 2013;22:482-95 pubmed publisher
    ..28E-07) with the age at onset of excessive daytime sleepiness, and rs12425451 near the transcription factor TEAD4 (P = 1.97E-07) with the age at onset of cataplexy...
  66. Qiao C, Jiang Y, Deng C, Huang Z, Teng K, Chen L, et al. Characterization of the transcriptional activation domains of human TEF3-1 (transcription enhancer factor 3 isoform 1). Arch Biochem Biophys. 2015;569:54-61 pubmed publisher
    b>TEF3-1 (transcription enhancer factor 3 isoform 1) is a human transcriptional factor, which has a N-terminal TEA/ATTS domain supposedly for DNA binding and C-terminal PRD and STY domains for transcriptional activation...
  67. Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, et al. DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. Oncogene. 2017;36:4362-4369 pubmed publisher
    ..b>TEAD4 acts as a critical downstream effector of the evolutionarily conserved Hippo signaling pathway...
  68. Mesrouze Y, Bokhovchuk F, Meyerhofer M, Fontana P, Zimmermann C, Martin T, et al. Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD. elife. 2017;6: pubmed publisher
  69. Zhou Y, Huang T, Zhang J, Wong C, Zhang B, Dong Y, et al. TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. Oncogene. 2017;36:6518-6530 pubmed publisher
    ..Their functional roles were determined by in vitro and in vivo studies. The clinicopathological association of TEAD4 in gastric cancer (GC) was studied using immunohistochemistry on tissue microarray...
  70. Byun M, Hwang J, Kim A, Kim K, Park J, Oh H, et al. SRC activates TAZ for intestinal tumorigenesis and regeneration. Cancer Lett. 2017;410:32-40 pubmed publisher
    ..of TAZ at Tyr316 by cSRC stimulates nuclear localization and facilitates transcriptional enhancer factor TEF-3 (TEAD4)-mediated transcription...
  71. Chen H, Baty C, Maeda T, Brooks S, Baker L, Ueyama T, et al. Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation. Circulation. 2004;110:2980-7 pubmed
    ..This mechanism may underlie some defects in cardiac conduction. ..
  72. Sakai N, Terami H, Suzuki S, Haga M, Nomoto K, Tsuchida N, et al. Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. J Endocrinol. 2008;198:489-97 pubmed publisher
    ..In addition, the gain of function studies indicated that sex-determining region Y (SRY)-box 15 (SOX15), TEA domain family member 4, KIAA1257 (a gene of unknown function), ADAM metallopeptidase with thrombospondin type 1 motif 6, ..
  73. Xie Q, Chen J, Feng H, Peng S, Adams U, Bai Y, et al. YAP/TEAD-mediated transcription controls cellular senescence. Cancer Res. 2013;73:3615-24 pubmed publisher
    ..Taken together, our findings define the critical role of YAP in the regulation of cellular senescence and provide a novel insight into a potential chemotherapeutic avenue for tumor suppression. ..
  74. He P, Philbrick M, An X, Wu J, Messmer Blust A, Li J. Endothelial differentiation gene-1, a new downstream gene is involved in RTEF-1 induced angiogenesis in endothelial cells. PLoS ONE. 2014;9:e88143 pubmed publisher
    ..Gi/Go protein coupled receptor pathway plays a role in RTEF-1 driven angiogenesis in endothelial cells. ..
  75. Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed publisher
    ..Our study establishes a molecular mechanism and functional significance of AMPK in linking cellular energy status to the Hippo-YAP pathway. ..
  76. Wang C, Nie Z, Zhou Z, Zhang H, Liu R, Wu J, et al. The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1. Oncotarget. 2015;6:17685-97 pubmed
    ..Here we found that TEAD4 was expressed in breast cancer cell lines, especially in triple negative breast cancers (TNBC) cell lines...
  77. Sun S, Cheng B, Sun P, Wu X, Wu Q, He P. RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation. Exp Biol Med (Maywood). 2015;240:1606-13 pubmed publisher
    ..These results reveal that RTEF-1 is a potential anti-oxidation gene and can prevent H2O2-induced endothelial cell oxidative damage by activating Klotho. ..
  78. Liu X, Li H, Rajurkar M, Li Q, Cotton J, Ou J, et al. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016;14:1169-1180 pubmed publisher
    ..Here, we characterize Tead4-mediated transcriptional networks in a diverse range of cancer cells, including neuroblastoma, colorectal, lung, ..
  79. Mori S, Takeuchi T, Ishii Y, Yugawa T, Kiyono T, Nishina H, et al. Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor. J Virol. 2017;91: pubmed publisher
    ..Reporter assays in HEK293 cells showed that exogenously expressed TEAD4 induced A3B promoter activation through binding to these sites...
  80. Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo Sakamoto Y, Koide N, et al. TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase. Biochem Biophys Res Commun. 2017;486:385-390 pubmed publisher
    TEA domain transcription factor 4 (TEAD4), which has critical functions in the process of embryonic development, is expressed in various cancers...
  81. Hosseini S, Moulavi F, TanhaieVash N, Shams Esfandabadi N, Nasr Esfahani M, Shirazi A. Evidence of Oocyte Polarity in Bovine; Implications for Intracytoplasmic Sperm Injection and Somatic Cell Nuclear Transfer. Cell J. 2017;19:482-491 pubmed publisher
    ..The relative abundances of Nanog, Oct4, Fgf4 and Tead4 were significantly higher in HNS oocyte fragment compared t0 FS...
  82. Stelitano D, Peche L, Dalla E, Monte M, Piazza S, Schneider C. GTSE1: a novel TEAD4-E2F1 target gene involved in cell protrusions formation in triple-negative breast cancer cell models. Oncotarget. 2017;8:67422-67438 pubmed publisher
    ..Here, we identified GTSE1 as a novel target gene of the TEAD4 transcription factor, highlighting a role for the YAP and TAZ coactivators in the transcriptional regulation of ..
  83. Messmer Blust A, Philbrick M, Guo S, Wu J, He P, Guo S, et al. RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium. Circ Res. 2012;111:991-1001 pubmed
    ..In contrast, vascular endothelial cadherin/RTEF-1-overexpressing(1) transgenic mice (VE-Cad/RTEF1) demonstrated improved glucose clearance and insulin sensitivity in response to a high-fat diet...
  84. Hau J, Erdmann D, Mesrouze Y, Furet P, Fontana P, Zimmermann C, et al. The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences. Chembiochem. 2013;14:1218-25 pubmed publisher
    ..This convergent optimization of the YAP/TAZ TEAD binding site suggests that the similarity in the affinities of binding of YAP to TEAD and of TAZ to TEAD is important for Hippo pathway functionality. ..
  85. Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014;25:166-80 pubmed publisher
    ..These findings suggest that disruption of YAP-TEADs interaction by a VGLL4-mimicking peptide may be a promising therapeutic strategy against YAP-driven human cancers. ..
  86. Wang W, Xiao Z, Li X, Aziz K, Gan B, Johnson R, et al. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol. 2015;17:490-9 pubmed publisher
  87. Lv X, Liu C, Wang Z, Sun Y, Xiong Y, Lei Q, et al. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep. 2015;16:975-85 pubmed publisher
    ..Our study indicates a potential molecular basis for cell growth-promoting function of PARD3 by modulating the Hippo pathway signaling in response to cell contact and cell polarity signals. ..
  88. Teng K, Deng C, Xu J, Men Q, Lei T, Di D, et al. Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer. Oncotarget. 2016;7:13827-41 pubmed publisher
    TEF3-1 (transcriptional enhancer factor 3 isoform 1), also known as TEAD4 (TEA domain family member 4), was recently revealed as an oncogenic character in cancer development...
  89. Kusama K, Bai R, Sakurai T, Bai H, Ideta A, Aoyagi Y, et al. A transcriptional cofactor YAP regulates IFNT expression via transcription factor TEAD in bovine conceptuses. Domest Anim Endocrinol. 2016;57:21-30 pubmed publisher
    ..YAP was expressed in bovine conceptuses and transfection of YAP or TEAD4, a transcription factor partner of YAP, expression plasmid increased the luciferase activity of IFNT2 and IFN-tau-..
  90. Suzuki M, Kondo A, Ogino I, Arai H, Tomita T, Sredni S. Overexpression of TEAD4 in atypical teratoid/rhabdoid tumor: New insight to the pathophysiology of an aggressive brain tumor. Pediatr Blood Cancer. 2017;64: pubmed publisher
    ..Furthermore, we investigated the function of this gene by mutating it in rhabdoid tumor cells. TEAD4 amplification was detected in the primary cell lines and its overexpression was confirmed at mRNA and protein ..
  91. Tang J, Yu C, Bao Y, Chen L, Chen J, Yang S, et al. TEAD4 promotes colorectal tumorigenesis via transcriptionally targeting YAP1. Cell Cycle. 2017;:1-23 pubmed publisher
    TEAD4 (TEA domain family member 4) was recently revealed as an oncogenic character in tumorigenesis. However, its role remains unclear in colorectal tumorigenesis...
  92. Edwards D, Ngwa V, Wang S, Shiuan E, Brantley Sieders D, Kim L, et al. The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ. Sci Signal. 2017;10: pubmed publisher
    ..The regulatory DNA elements of both SLC1A5 and GLS contain TEAD binding sites and were bound by TEAD4 in an EphA2-dependent manner...