TDGF1

Summary

Gene Symbol: TDGF1
Description: teratocarcinoma-derived growth factor 1
Alias: CRGF, CRIPTO, teratocarcinoma-derived growth factor 1, cripto-1 growth factor, epidermal growth factor-like cripto protein CR1
Species: human
Products:     TDGF1

Top Publications

  1. Ciccodicola A, Dono R, Obici S, Simeone A, Zollo M, Persico M. Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J. 1989;8:1987-91 pubmed
    ..Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells. ..
  2. Kelber J, Panopoulos A, Shani G, Booker E, Belmonte J, Vale W, et al. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. Oncogene. 2009;28:2324-36 pubmed publisher
    b>Cripto is a developmental oncoprotein that signals via mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (PI3K)/Akt and Smad2/3 pathways...
  3. Yan Y, Liu J, Luo Y, E C, Haltiwanger R, Abate Shen C, et al. Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol. 2002;22:4439-49 pubmed
    The EGF-CFC gene Cripto encodes an extracellular protein that has been implicated in the signaling pathway for the transforming growth factor beta (TGF beta) ligand Nodal...
  4. Miyoshi N, Ishii H, Mimori K, Sekimoto M, Doki Y, Mori M. TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer. Int J Oncol. 2010;36:563-8 pubmed
    Teratocarcinoma-derived growth factor 1 (TDGF1) is a member of the epidermal growth factor-cripto FRL1 cryptic protein family and is involved in the activation of several different signaling pathways during embryonic development and ..
  5. Gray P, Shani G, Aung K, Kelber J, Vale W. Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling. Mol Cell Biol. 2006;26:9268-78 pubmed
    b>Cripto is a developmental oncoprotein and a member of the epidermal growth factor-Cripto, FRL-1, Cryptic family of extracellular signaling molecules...
  6. Normanno N, De Luca A, Bianco C, Maiello M, Carriero M, Rehman A, et al. Cripto-1 overexpression leads to enhanced invasiveness and resistance to anoikis in human MCF-7 breast cancer cells. J Cell Physiol. 2004;198:31-9 pubmed
    b>Cripto-1 (CR-1) is an epidermal growth factor (EGF)-CFC protein that has been shown to signal through nodal/Alk-4, PI3K/Akt, and/or ras/raf/MEK/MAPK pathways in mammalian cells, and that is frequently expressed in human primary breast ..
  7. Ebert A, Wechselberger C, Frank S, Wallace Jones B, Seno M, Martinez Lacaci I, et al. Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells. Cancer Res. 1999;59:4502-5 pubmed
    b>Cripto-1 (CR-1), a member of the epidermal growth factor-CFC peptide family, activates the ras/raf/mitogen-activated protein/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway...
  8. Brandt R, Normanno N, Gullick W, Lin J, Harkins R, Schneider D, et al. Identification and biological characterization of an epidermal growth factor-related protein: cripto-1. J Biol Chem. 1994;269:17320-8 pubmed
    The human and mouse cripto-1 (CR-1) genes can code for proteins related in structure to epidermal growth factor (EGF)...
  9. Friess H, Yamanaka Y, Buchler M, Kobrin M, Tahara E, Korc M. Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis. Int J Cancer. 1994;56:668-74 pubmed
    b>Cripto is a 188 amino-acid protein containing a central segment that shares amino-acid sequence homology with epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha)...

More Information

Publications73

  1. Kannan S, De Santis M, Lohmeyer M, Riese D, Smith G, Hynes N, et al. Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. J Biol Chem. 1997;272:3330-5 pubmed
    b>Cripto-1 (CR-1), a recently discovered protein of the epidermal growth factor (EGF) family, was found to interact with a high affinity, saturable binding site(s) on HC-11 mouse mammary epithelial cells and on several different human ..
  2. Bianco C, Castro N, Baraty C, Rollman K, Held N, Rangel M, et al. Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells. J Cell Physiol. 2013;228:1174-88 pubmed publisher
    Human Cripto-1 (CR-1) plays an important role in regulating embryonic development while also regulating various stages of tumor progression...
  3. Bianco C, Strizzi L, Mancino M, Rehman A, Hamada S, Watanabe K, et al. Identification of cripto-1 as a novel serologic marker for breast and colon cancer. Clin Cancer Res. 2006;12:5158-64 pubmed
    Human Cripto-1 (CR-1), a cell membrane glycosylphosphatidylinositol-anchored glycoprotein that can also be cleaved from the membrane, is expressed at high levels in several different types of human tumors...
  4. Adkins H, Bianco C, Schiffer S, Rayhorn P, Zafari M, Cheung A, et al. Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo. J Clin Invest. 2003;112:575-87 pubmed
    b>Cripto, a cell surface-associated protein belonging to the EGF-CFC family of growth factor-like molecules, is overexpressed in many human solid tumors, including 70-80% of breast and colon tumors, yet how it promotes cell transformation ..
  5. Rangel M, Karasawa H, Castro N, Nagaoka T, Salomon D, Bianco C. Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer. Am J Pathol. 2012;180:2188-200 pubmed publisher
    ..b>Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family, together with the ..
  6. Bianco C, Strizzi L, Rehman A, Normanno N, Wechselberger C, Sun Y, et al. A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src. Cancer Res. 2003;63:1192-7 pubmed
    Human Cripto-1 (CR-1) is a member of the epidermal growth factor-Cripto FRL1 Cryptic family that has been shown to function as a coreceptor with the type I Activin serine-threonine kinase receptor ALK4 for the transforming growth factor ..
  7. Bianco C, Adkins H, Wechselberger C, Seno M, Normanno N, De Luca A, et al. Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. Mol Cell Biol. 2002;22:2586-97 pubmed
    b>Cripto-1 (CR-1), an epidermal growth factor-CFC (EGF-CFC) family member, has a demonstrated role in embryogenesis and mammary gland development and is overexpressed in several human tumors...
  8. Torres P, Florio P, Galleri L, Reis F, Borges L, Petraglia F. Activin A, activin receptor type II, nodal, and cripto mRNA are expressed by eutopic and ectopic endometrium in women with ovarian endometriosis. Reprod Sci. 2009;16:727-33 pubmed publisher
    ..Nodal is an activin competitor that requires the coreceptor cripto to assemble its signaling pathway through ActRI and ActRII...
  9. Reissmann E, Jornvall H, Blokzijl A, Andersson O, Chang C, Minchiotti G, et al. The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes Dev. 2001;15:2010-22 pubmed
    ..Both receptors can independently bind Xnr1. In addition, Cripto, an extracellular protein genetically implicated in Nodal signaling, can independently interact with both Xnr1 and ..
  10. Xu C, Liguori G, Persico M, Adamson E. Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development. 1999;126:483-94 pubmed
    b>Cripto-1(Cr1) protein encoded by the tdgf1 gene, is a secreted growth factor that is expressed early in embryonic development and is re-expressed in some tumors of the breast and colon...
  11. Jiang P, Zhu L, Fan Y, Zhao H. Clinicopathological and biological significance of cripto overexpression in human colon cancer. World J Gastroenterol. 2013;19:8630-7 pubmed publisher
    To assess the clinicopathological and biological significance of cripto in human colorectal cancer...
  12. De Luca A, Lamura L, Strizzi L, Roma C, D Antonio A, Margaryan N, et al. Expression and functional role of CRIPTO-1 in cutaneous melanoma. Br J Cancer. 2011;105:1030-8 pubmed publisher
    b>CRIPTO-1 (CR-1) is involved in the pathogenesis and progression of human carcinoma of different histological origin. In this study we addressed the expression and the functional role of CR-1 in cutaneous melanoma...
  13. Nagaoka T, Karasawa H, Turbyville T, Rangel M, Castro N, Gonzales M, et al. Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal. 2013;25:178-89 pubmed publisher
    b>Cripto-1 is implicated in multiple cellular events, including cell proliferation, motility and angiogenesis, through the activation of an intricate network of signaling pathways...
  14. Kelber J, Shani G, Booker E, Vale W, Gray P. Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal. J Biol Chem. 2008;283:4490-500 pubmed
    b>Cripto plays critical roles during embryogenesis and has been implicated in promoting the growth and spread of tumors...
  15. Chen F, Hou S, Fan H, Liu Y. MiR-15a-16 represses Cripto and inhibits NSCLC cell progression. Mol Cell Biochem. 2014;391:11-9 pubmed publisher
    ..study, downregulation of miR-15a-16 in nonsmall cell lung cancer (NSCLC) was found to be inversely correlated with Cripto. Results from the Luciferase reporter assay and Western blot analysis also confirmed that Cripto is a direct ..
  16. Strizzi L, Margaryan N, Gilgur A, Hardy K, Normanno N, Salomon D, et al. The significance of a Cripto-1 positive subpopulation of human melanoma cells exhibiting stem cell-like characteristics. Cell Cycle. 2013;12:1450-6 pubmed publisher
    b>Cripto-1 (CR-1) protein function differs according to cellular or extracellular expression. In this study, we explore the significance of cell surface CR-1 expression in human melanoma cells...
  17. Gray P, Harrison C, Vale W. Cripto forms a complex with activin and type II activin receptors and can block activin signaling. Proc Natl Acad Sci U S A. 2003;100:5193-8 pubmed
    ..by nodal, Vg1, and growth and differentiation factor 1 requires a coreceptor from the epidermal growth factor-Cripto-FRL1-Cryptic protein family such as Cripto...
  18. Salomon D, Bianco C, De Santis M. Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia. Bioessays. 1999;21:61-70 pubmed
    ..b>Cripto-1 (CR-1, human; Cr-1, mouse)--also known as teratocarcinoma-derived growth factor-1--is a novel EGF-related ..
  19. Gray P, Vale W. Cripto/GRP78 modulation of the TGF-? pathway in development and oncogenesis. FEBS Lett. 2012;586:1836-45 pubmed publisher
    b>Cripto is a small, GPI-anchored signaling protein that regulates cellular survival, proliferation, differentiation and migration during normal developmental processes and tumorigenesis...
  20. Hentschke M, Kurth I, Borgmeyer U, Hübner C. Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3. J Biol Chem. 2006;281:33497-504 pubmed
    ..b>CRIPTO-1, a co-receptor for the morphogen nodal, is strongly expressed in undifferentiated cells and is rapidly down-..
  21. Watanabe K, Meyer M, Strizzi L, Lee J, Gonzales M, Bianco C, et al. Cripto-1 is a cell surface marker for a tumorigenic, undifferentiated subpopulation in human embryonal carcinoma cells. Stem Cells. 2010;28:1303-14 pubmed publisher
    ..In addition, genes that are associated with early embryogenesis are frequently expressed in cancer. Cripto-1 (CR-1), a glycosylphosphatidylinositol-linked glycoprotein, is expressed during early embryogenesis and in ..
  22. Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, et al. Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J Biol Chem. 2007;282:31643-55 pubmed
    b>Cripto-1 (CR-1) is a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein that has been shown to play an important role in embryogenesis and cellular transformation...
  23. Hamada S, Watanabe K, Hirota M, Bianco C, Strizzi L, Mancino M, et al. beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1. Biochem Biophys Res Commun. 2007;355:240-4 pubmed
    The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family...
  24. Adamson E, Minchiotti G, Salomon D. Cripto: a tumor growth factor and more. J Cell Physiol. 2002;190:267-78 pubmed
    b>Cripto, a growth factor with an EGF-like domain, and the first member of the EGF-CFC family of genes to be sequenced and characterized, contributes to deregulated growth of cancer cells...
  25. Zhong X, Zhang L, Jia S, Shi T, Niu Z, Du H, et al. Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer. Histopathology. 2008;52:560-8 pubmed publisher
    b>Cripto-1 may be capable of up-regulating signalling molecules associated with epithelial-to-mesenchymal transition (EMT), an important event characterized by loss of E-cadherin during malignant tumour progression and metastasis...
  26. Wu Z, Li G, Wu L, Weng D, Li X, Yao K. Cripto-1 overexpression is involved in the tumorigenesis of nasopharyngeal carcinoma. BMC Cancer. 2009;9:315 pubmed publisher
    Human Cripto-1, a member of the EGF-CFC family, is indispensable for early embryonic development...
  27. Mancino M, Strizzi L, Wechselberger C, Watanabe K, Gonzales M, Hamada S, et al. Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells. J Cell Physiol. 2008;215:192-203 pubmed
    Human Cripto-1 (CR-1) is a cell membrane protein that is overexpressed in several different types of human carcinomas. In the present study we investigated the mechanisms that regulate the expression of CR-1 gene in cancer cells...
  28. Xu C, Liguori G, Adamson E, Persico M. Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1. Dev Biol. 1998;196:237-47 pubmed
    ..Here we describe the involvement of a growth factor with an EGF-like domain, Cripto-1 (Cr-1), in cardiac differentiation...
  29. Ligtenberg M, Witt K, Gálvez Cancino F, Sette A, Lundqvist A, Lladser A, et al. Cripto-1 vaccination elicits protective immunity against metastatic melanoma. Oncoimmunology. 2016;5:e1128613 pubmed publisher
    ..b>Cripto-1 is frequently over-expressed in human carcinomas and melanomas, but is expressed only at low levels on normal ..
  30. Marikawa Y, Tamashiro D, Fujita T, Alarcon V. Dual roles of Oct4 in the maintenance of mouse P19 embryonal carcinoma cells: as negative regulator of Wnt/β-catenin signaling and competence provider for Brachyury induction. Stem Cells Dev. 2011;20:621-33 pubmed publisher
    ..Microarray analysis revealed that Oct4 positively regulated the expression of Tdgf1, a critical component of Nodal signaling, which was required for the upregulation of Brachyury in response to Wnt/..
  31. Yoon H, Hong J, Shin W, Lee Y, Hong K, Lee J, et al. The role of Cripto-1 in the tumorigenesis and progression of oral squamous cell carcinoma. Oral Oncol. 2011;47:1023-31 pubmed publisher
    ..b>Cripto-1 is a member of the epidermal growth factor (EGF)-CFC protein family and is involved in the activation of several ..
  32. Wang B, Yan J, Peng Z, Wang J, Liu S, Xie X, et al. Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. Int J Cardiol. 2011;146:225-7 pubmed publisher
    The goal of our study was to identify potential pathogenic mutations in the TDGF1 gene in Chinese people with isolated CHD, particularly those with VSD, and to provide further insight into the etiology of CHD...
  33. Sun G, Yan S, Shi L, Wan Z, Jiang N, Fu L, et al. MicroRNA-15b suppresses the growth and invasion of glioma cells through targeted inhibition of cripto-1 expression. Mol Med Rep. 2016;13:4897-903 pubmed publisher
    ..Studies have identified that miR?15b is negatively correlated with cripto-1 expression in glioma cells, and these molecules serve an important role in cancer development and progression...
  34. Lee S, Jeon M, Kim J, Jeon I, Byun S. The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development. Mol Reprod Dev. 2015;82:967-75 pubmed publisher
    ..Our data further indicate that TGFBR1 and LIN28B maintain pluripotency by regulating POUV, NANOG, and CRIPTO. Therefore, gga-let-7 miRNAs act as post-transcriptional regulators of differentiation in blastodermal cells by ..
  35. Rangel M, Bertolette D, Castro N, Klauzinska M, Cuttitta F, Salomon D. Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer. Breast Cancer Res Treat. 2016;156:211-26 pubmed publisher
    ..The master regulators of embryonic development Cripto-1, Notch/CSL, and Wnt/β-catenin play key roles in modulating mammary gland morphogenesis and cell fate ..
  36. Aykul S, Parenti A, Chu K, Reske J, Floer M, Ralston A, et al. Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic. J Biol Chem. 2017;292:4138-4151 pubmed publisher
    ..of EGF-CFC proteins have been described, but their molecular functions, including how the mammalian homologs Cripto-1 and Cryptic recognize and regulate TGF-β family ligands, are less clear...
  37. Parisi S, D Andrea D, Lago C, Adamson E, Persico M, Minchiotti G. Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J Cell Biol. 2003;163:303-14 pubmed
    ..We have investigated the role of Cripto, an EGF-CFC factor, in the earliest stages of cardiomyogenesis...
  38. Focà A, Sanguigno L, Focà G, Strizzi L, Iannitti R, Palumbo R, et al. New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding. Int J Mol Sci. 2015;16:21342-62 pubmed publisher
    ..Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1...
  39. Zhang J, Zhao J, Xin Y. Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions. World J Gastroenterol. 2010;16:571-7 pubmed
    To explore the relationship between Cripto-1 (CR-1) and tyrosine phosphorylation STAT3 (p-STAT3) expressions in gastric cancer (GC) and gastric carcinogensis and metastasis...
  40. Wei B, Jin W, Ruan J, Xu Z, Zhou Y, Liang J, et al. Cripto-1 expression and its prognostic value in human bladder cancer patients. Tumour Biol. 2015;36:1105-13 pubmed publisher
    b>Cripto-1 is an important embryonic gene that involved in self-renewal and maintenance of pluripotency of stem cells...
  41. Tribulo P, Siqueira L, Oliveira L, Scheffler T, Hansen P. Identification of potential embryokines in the bovine reproductive tract. J Dairy Sci. 2018;101:690-704 pubmed publisher
    ..FGF1, FGF2, GRO1, HGF, IGF1, IL1B, IL8, SFRP1, SFRP4, WNT5A, and WNT16), and 7 at d 7 (CXCL16, FGF13, HDGFRP2, TDGF1, VEGFB, WNT7A, and WNT11)...
  42. Perino M, Yamanaka S, Riordon D, Tarasova Y, Boheler K. Ascorbic acid promotes cardiomyogenesis through SMAD1 signaling in differentiating mouse embryonic stem cells. PLoS ONE. 2017;12:e0188569 pubmed publisher
    ..SMAD2/3 activator Activin A with AA had no significant effect, but the addition of the nodal co-receptor TDGF1 (Cripto) antagonized AA's cardiomyogenic-promoting ability...
  43. Bao S, Tang W, Wu B, Kim S, Li J, Li L, et al. Derivation of hypermethylated pluripotent embryonic stem cells with high potency. Cell Res. 2017;: pubmed publisher
    ..with the expression of both naive pluripotency genes, as well as mesodermal somatic genes; Eomes, Eras, Tdgf1, Evx1, hand1, Wnt5a and distinct repetitive elements. Conversion of established ESCs to ASCs is also achievable...
  44. Cruz C, Del Puerto H, Rocha A, Cavallo I, Clarizia A, Petraglia F, et al. Expression of Nodal, Cripto, SMAD3, phosphorylated SMAD3, and SMAD4 in the proliferative endometrium of women with endometriosis. Reprod Sci. 2015;22:527-33 pubmed publisher
    ..The effects of Nodal are modulated by the coreceptor Cripto and mediated by SMAD proteins...
  45. Li G, Kung A, Huang Q. Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women. Osteoporos Int. 2010;21:1009-20 pubmed publisher
    ..Thirty SNPs in five positional and functional candidate genes within 3p14-25 (PPARG, CRTAP, TDGF1, PTHR1, and FLNB) and rs7646054 in the ARHGEF3 gene were genotyped in a case-control cohort of 1,080 Chinese ..
  46. Watanabe K, Salomon D. Intercellular transfer regulation of the paracrine activity of GPI-anchored Cripto-1 as a Nodal co-receptor. Biochem Biophys Res Commun. 2010;403:108-13 pubmed publisher
    b>Cripto-1 (CR-1) is a glycosylphosphatidylinositol-anchored glycoprotein which acts as an obligate co-receptor of a TGFβ family ligand, Nodal...
  47. Spiller C, Feng C, Jackson A, Gillis A, Rolland A, Looijenga L, et al. Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. Development. 2012;139:4123-32 pubmed publisher
    ..Here, we show that signaling by the TGF? morphogen Nodal and its co-receptor Cripto is active during a crucial window of male germ cell development...
  48. Saccone S, Rapisarda A, Motta S, Dono R, Persico G, Della Valle G. Regional localization of the human EGF-like growth factor CRIPTO gene (TDGF-1) to chromosome 3p21. Hum Genet. 1995;95:229-30 pubmed
    The CRIPTO gene encodes a novel human growth factor structurally related to epidermal growth factor...
  49. Panico L, D Antonio A, Salvatore G, Mezza E, Tortora G, De Laurentiis M, et al. Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues. Int J Cancer. 1996;65:51-6 pubmed
    The expression of growth factors, such as transforming growth factor alpha (TGF alpha), amphiregulin (AR) and CRIPTO, a type-1 tyrosine-kinase growth factor receptor (erbB-2), and a tumor-suppressor gene (p53), that have been implicated ..
  50. Zhang H, Zhang B, Gao L, Zhang L, Zhu K, Cheng R, et al. Clinical significance of cripto-1 expression in lung adenocarcinoma. Oncotarget. 2017;8:79087-79098 pubmed publisher
    b>Cripto-1 can promote tumourigenesis and may be a potential prognostic biomarker in several malignancies, yet little is known about this protein in lung adenocarcinoma (LAC)...
  51. Hong S, Lee E, Park J, Jeon T, Bang S, Park S, et al. Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas. Oncol Rep. 2009;21:19-24 pubmed
    Human Cripto-1, a membrane-bound protein, plays an important role during early embryogenesis and has oncogenic properties, including cell transformation and enhancement of invasion...
  52. Williams T, Monticone S, Morello F, Liew C, Mengozzi G, Pilon C, et al. Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. Hypertension. 2010;55:1468-75 pubmed publisher
  53. Wang J, Wei W, Xu J, Guo Z, Xiao C, Zhang Y, et al. Elevated expression of Cripto-1 correlates with poor prognosis in hepatocellular carcinoma. Oncotarget. 2015;6:35116-28 pubmed publisher
    b>Cripto-1 could promote tumorigenesis in a wide range of carcinomas, yet little is known in hepatocellular carcinoma (HCC). The expression of Cripto-1 and MMP-9 were assessed by immunohistochemistry in 205 HCC specimens...
  54. Xu C, Sheng Z, Hu H, Hao K, Wang Q, Yu L. Elevated expression of Cripto-1 correlates with poor prognosis in non-small cell lung cancer. Tumour Biol. 2014;35:8673-8 pubmed publisher
    Human Cripto-1 (CR-1) plays an important oncogenic role during tumorigenesis and is overexpressed in a wide range of carcinomas, yet little is known about CR-1 in non-small cell lung cancer (NSCLC)...
  55. Xu C, Cao L, Wei Y, Yu L. Serum cripto-1 as a clinical marker for lung cancer. Int J Biol Markers. 2015;30:e369-73 pubmed publisher
    b>Cripto-1 (CR-1) plays an important role in angiogenesis related to tumor growth, in concert with vascular endothelial growth factor (VEGF), and enhanced expression of CR-1 has been reported in lung cancer tissue...
  56. Shan Y, Li S. Expression of Cripto-1 gene protein and Activin-A in human lung adenocarcinoma tissue. Pak J Pharm Sci. 2015;28:739-43 pubmed
    To research the expression in human lung adenocarcinoma tissue of Cripto-1 (teratocarcinoma derived growth factor-1) gene protein and Activin-A gene protein, and explore the relationship and clinical significance between the two gene ..
  57. Ruggiero D, Nappo S, Nutile T, Sorice R, Talotta F, Giorgio E, et al. Genetic variants modulating CRIPTO serum levels identified by genome-wide association study in Cilento isolates. PLoS Genet. 2015;11:e1004976 pubmed publisher
    b>Cripto, the founding member of the EGF-CFC genes, plays an essential role in embryo development and is involved in cancer progression...
  58. Klauzinska M, Bertolette D, Tippireddy S, Strizzi L, Gray P, Gonzales M, et al. Cripto-1: an extracellular protein - connecting the sequestered biological dots. Connect Tissue Res. 2015;56:364-80 pubmed publisher
    b>Cripto-1 (CR-1) is a multifunctional embryonic protein that is re-expressed during inflammation, wound repair, and malignant transformation...
  59. Liu Y, Qin Z, Yang K, Liu R, Xu Y. Cripto-1 promotes epithelial-mesenchymal transition in prostate cancer via Wnt/?-catenin signaling. Oncol Rep. 2017;37:1521-1528 pubmed publisher
    The Cripto-1 (CR-1) derived EGF-CFC family was overexpressed in tumor development enhancing proliferation, epithelial-mesenchymal transition (EMT) and migration of tumor cells...
  60. Park K, Raffeld M, Moon Y, Xi L, Bianco C, Pham T, et al. CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance. J Clin Invest. 2014;124:3003-15 pubmed publisher
  61. Zoni E, Chen L, Karkampouna S, Granchi Z, Verhoef E, La Manna F, et al. CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer. Oncogene. 2017;36:4739-4749 pubmed publisher
    b>CRIPTO (CR-1, TDGF1) is a cell surface/secreted oncoprotein actively involved in development and cancer...
  62. Calvanese L, Focà A, Sandomenico A, Focà G, Caporale A, Doti N, et al. Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy. Bioorg Med Chem. 2017;25:6589-6596 pubmed publisher
    ..Targeting of Nodal signaling, which occurs via the binding to Cripto-1 co-receptor, results in inhibition of cell aggressiveness and reduced tumor growth...
  63. Park S, Do H, Han M, Choi W, Kim J. The expression of the embryonic gene Cripto-1 is regulated by OCT4 in human embryonal carcinoma NCCIT cells. FEBS Lett. 2017;: pubmed publisher
    b>Cripto-1 and OCT4, expressed in stem cells and cancers, play important roles in tumorigenesis. Here, we demonstrate that Cripto-1 expression is regulated by OCT4 in human embryonic carcinoma NCCIT cells...
  64. Bandeira C, Urban Borbely A, Pulcineli Vieira Francisco R, Schultz R, Zugaib M, Bevilacqua E. Tumorigenic factor CRIPTO-1 is immunolocalized in extravillous cytotrophoblast in placenta creta. Biomed Res Int. 2014;2014:892856 pubmed publisher
    b>CRIPTO-(CR)1 is a protein associated with tumorigenesis and metastasis. Here we demonstrate that CR-1 expression in normal and creta placentas is associated with various degrees of uterine invasion...