Gene Symbol: TCF7
Description: transcription factor 7
Alias: TCF-1, transcription factor 7, T-cell-factor-7, T-cell-specific transcription factor 1, transcription factor 7 (T-cell specific, HMG-box)
Species: human
Products:     TCF7

Top Publications

  1. van de Wetering M, Oosterwegel M, Dooijes D, Clevers H. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. EMBO J. 1991;10:123-32 pubmed
    ..These results identify TCF-1 as a T cell-specific transcription factor, which might play a role in the establishment of the mature T cell phenotype. ..
  2. van de Wetering M, Castrop J, Korinek V, Clevers H. Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol Cell Biol. 1996;16:745-52 pubmed
  3. Roose J, Molenaar M, Peterson J, Hurenkamp J, Brantjes H, Moerer P, et al. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature. 1998;395:608-12 pubmed
    ..These data indicate that expression of Tcf target genes is regulated by a balance between Armadillo and Groucho. ..
  4. Mao C, Byers S. Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials. Crit Rev Eukaryot Gene Expr. 2011;21:207-36 pubmed
    ..tuning of this transcriptional switch is also achieved by the cell-context-dependent expression of four members (TCF7, TCF7L1, TCF7L2, and LEF1) and numerous variants, which display differential DNA binding affinity and specificity, ..
  5. Brantjes H, Roose J, van de Wetering M, Clevers H. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res. 2001;29:1410-9 pubmed
    ..Although Grg-5 contains the GP homology domain that mediates HDAC binding in long Grg proteins, Grg-5 fails to bind this co-repressor, explaining how it can de-repress transcription. ..
  6. Smit L, Baas A, Kuipers J, Korswagen H, van de Wetering M, Clevers H. Wnt activates the Tak1/Nemo-like kinase pathway. J Biol Chem. 2004;279:17232-40 pubmed
    ..Thus, Wnt signal transduction through the canonical pathway activates beta-catenin/TCF, whereas Wnt signal transduction through the Tak1 pathway phosphorylates and inhibits TCF, which might function as a feedback mechanism. ..
  7. Ito K, Lim A, Salto Tellez M, Motoda L, Osato M, Chuang L, et al. RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell. 2008;14:226-37 pubmed publisher
    ..Taken together, these data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling. ..
  8. Hikasa H, Sokol S. Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2. J Biol Chem. 2011;286:12093-100 pubmed publisher
    ..These observations emphasize a critical role for Wnt/HIPK2-dependent TCF phosphorylation and suggest that TCF switching is an important mechanism of Wnt target gene activation in vertebrate embryos...
  9. Hoverter N, Ting J, Sundaresh S, Baldi P, Waterman M. A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs. Mol Cell Biol. 2012;32:3648-62 pubmed publisher
    ..The C-clamp-RCCG interaction was critical for TCF1E-mediated transcriptional control of p21-connected target gene promoters. Our results indicate that a rapid-response WNT/p21 circuit is driven by C-clamp target gene selection. ..

More Information

Publications155 found, 100 shown here

  1. Kel A, Boyarskikh U, Stegmaier P, Leskov L, Sokolov A, Yevshin I, et al. Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer. BMC Bioinformatics. 2019;20:119 pubmed publisher
    ..The markers include hypermethylated positions in regulatory regions of the following genes: CALCA, ENO1, MYC, PDX1, TCF7, ZNF43.
  2. Chen X, Shen Y, He M, Yang F, Yang P, Pang F, et al. Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/β-catenin signaling pathway. Biomed Pharmacother. 2019;112:108746 pubmed publisher
    ..DLX5, osteocalcin, collagen type I and BMP2) and components of the Wnt signaling pathway (β-catenin, Lef1, TCF7, c-jun, c-myc and cyclin D)...
  3. Lutgen V, Narasipura S, Sharma A, Min S, Al Harthi L. β-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes. J Neuroinflammation. 2016;13:242 pubmed publisher
  4. Li W, Jiang Z, Li T, Wei X, Zheng Y, Wu D, et al. Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes. Mol Cancer. 2015;14:26 pubmed publisher
    ..We found that KLF4 overexpression inhibited T cell-associated genes including NOTCH1, BCL11B, GATA3, and TCF7. Further mechanistic studies revealed that KLF4 directly bound to the promoters of NOTCH1, BCL2, and CXCR4 and ..
  5. Wei Q, Zhang J, Hong G, Chen Z, Deng W, He W, et al. Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ER?-Wnt/?-catenin signaling pathway. Biomed Pharmacother. 2016;84:931-939 pubmed publisher
    ..genes (Runx2, osteopotin, DLX5, osteocalcin, collagen type I, and ER?) and Wnt signal members (?-catenin, Lef1, TCF7, c-jun, c-myc, and cyclin D)...
  6. Frost J, Estivill X, Ramsay M, Tikly M. Dysregulation of the Wnt signaling pathway in South African patients with diffuse systemic sclerosis. Clin Rheumatol. 2019;38:933-938 pubmed publisher
    ..These two groups showed paradoxical gene expression of the genes TCF7, SOX17, and FRZB in affected and unaffected skin...
  7. Zhou R, Yuan Z, Liu J, Liu J. Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells. Mol Med Rep. 2016;13:4689-96 pubmed publisher
    ..of osteoblastic genes associated with the Wnt/??catenin pathway, including the mRNA of c?myc, cyclin D1, Lef1, Tcf7 and ??catenin as well as ??catenin protein...
  8. Nanjappa S, Heninger E, Wüthrich M, Gasper D, Klein B. Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog. 2012;8:e1002771 pubmed publisher
    ..Our work has implications for designing vaccines against fungal infections in immune suppressed patients. ..
  9. Liu C, Lin W, Wu C, Hsu S, Wang C, Chung J, et al. Lauryl Gallate Induces Apoptotic Cell Death through Caspase-dependent Pathway in U87 Human Glioblastoma Cells In Vitro. In Vivo. 2018;32:1119-1127 pubmed publisher
    ..Furthermore, LG also suppressed the expression of p-Akt, Pak1, Hif-1α and Hif-2α, β-catenin and Tcf-1 in U87 cells. These results suggest that LG induced apoptotic cell death via the caspase-dependent pathway in U87 cells. ..
  10. Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, et al. Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells. Immunity. 2018;48:937-950.e8 pubmed publisher
    ..Our results identify TOX as a transcriptional regulator of tissue-destructive CTLs in autoimmunity, offering a potential mechanistic link to microbial triggers. ..
  11. Komori T. Roles of Runx2 in Skeletal Development. Adv Exp Med Biol. 2017;962:83-93 pubmed publisher
    ..This enhancer is activated by an enhanceosome composed of Dlx5/6, Mef2, Tcf7, Ctnnb1, Sox5/6, Smad1, and Sp7...
  12. Abdelsamed H, Moustaki A, Fan Y, Dogra P, Ghoneim H, Zebley C, et al. Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis. J Exp Med. 2017;214:1593-1606 pubmed publisher phenotypic conversion into TEM cells and was coupled to increased methylation of the CCR7 and Tcf7 loci...
  13. Shen L, Zhang S, Li Q, Fu Y, Tang G, Jiang Y, et al. The Landscape of Non-Coding RNA in an Adult Pig Model of Intrauterine Growth Restriction. Cell Physiol Biochem. 2018;50:1764-1778 pubmed publisher
    ..05). Interestingly, our results identified ATF4-miR214-circRNA7964 and TCF7-miR22-3p-circRNA16347 as two competing endogenous networks, which were closely associated with the observed ..
  14. Chen D, Lin X, Zhang C, An G, Li Z, Dong B, et al. Activated Wnt signaling promotes growth and progression of AFP-producing gastric cancer in preclinical models. Cancer Manag Res. 2019;11:1349-1362 pubmed publisher
    ..decreased Axin 1 and pGSK3β, followed by cascade activation of β-catenin, downstream transcription factors TCF1/TCF7, and the target gene - c-Myc...
  15. Zhao Y, Ji T, Luo Q, Yu J. Long non-coding RNA H19 induces hippocampal neuronal apoptosis via Wnt signaling in a streptozotocin-induced rat model of diabetes mellitus. Oncotarget. 2017;8:64827-64839 pubmed publisher
    ..These results suggest that lncRNA H19 induces hippocampal neuronal apoptosis via Wnt signaling, and that inhibition of lncRNA H19 may serve as a promising novel target for the treatment of cognitive decline in patients with DM...
  16. Harker J, Wong K, Dolgoter A, Zuniga E. Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity. J Immunol. 2015;195:1071-81 pubmed publisher
    ..virus-specific CD8(+) T cells showed a reduced proportion of memory cells, which expressed lower levels of Tcf7, and displayed diminished recall responses on secondary infection...
  17. Kennedy M, Chalamalasetty R, Thomas S, Garriock R, Jailwala P, Yamaguchi T. Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016;113:3545-50 pubmed publisher
    ..Because Sp5 is itself directly activated by Wnt signals, we propose that Sp5 is a Wnt/β-catenin pathway-specific transcript on factor that functions in a feed-forward loop to robustly activate select Wnt target genes. ..
  18. Lynch T, Anderson P, Rotti P, Tyler S, Crooke A, Choi S, et al. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 2018;22:653-667.e5 pubmed publisher
    ..MECs activate Wnt-regulated transcription factors (Lef-1/TCF7) following injury and Lef-1 induction in cultured MECs promoted transition to a basal cell phenotype...
  19. Yepes S, Torres M, López Kleine L. Regulatory network reconstruction reveals genes with prognostic value for chronic lymphocytic leukemia. BMC Genomics. 2015;16:1002 pubmed publisher
    ..b>TCF7 and its targets stood out for their roles in progression...
  20. Jatzek A, Tejera M, Singh A, Sullivan J, Plisch E, Suresh M. p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory. J Immunol. 2012;189:5119-28 pubmed publisher
    ..Collectively, these findings provide key insights into the mechanisms underlying the governance of peripheral CD4 T cell homeostasis and identify p27(Kip1) as a target to enhance vaccine-induced CD4 T cell memory. ..
  21. Utzschneider D, Delpoux A, Wieland D, Huang X, Lai C, Hofmann M, et al. Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1. Cell Rep. 2018;22:3454-3467 pubmed publisher chronic infections, as a loss of FOXO1 during a persistent viral infection led to a rapid decline of the TCF7 (a.k.a. TCF1)-expressing memory-like subset of CD8+ T cells...
  22. Ladle B, Li K, Phillips M, Pucsek A, Haile A, Powell J, et al. De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation. Proc Natl Acad Sci U S A. 2016;113:10631-6 pubmed publisher attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8(+) T cells...
  23. Herzig Y, Nevo S, Bornstein C, Brezis M, Ben Hur S, Shkedy A, et al. Transcriptional programs that control expression of the autoimmune regulator gene Aire. Nat Immunol. 2017;18:161-172 pubmed publisher
    ..specific demethylation of exon 2 and the proximal promoter, and the coordinated action of several transcription activators, including Irf4, Irf8, Tbx21, Tcf7 and Ctcfl, which acted on mTEC-specific accessible regions in the Aire locus.
  24. Kurtulus S, Madi A, Escobar G, Klapholz M, Nyman J, Christian E, et al. Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells. Immunity. 2018;: pubmed publisher
    ..T cells associated with response to checkpoint blockade in patients and was compromised in the absence of Tcf7. Expression of Tcf7/Tcf1 was requisite for the efficacy of diverse immunotherapies, highlighting the importance of ..
  25. Kueh H, Yui M, Ng K, Pease S, Zhang J, Damle S, et al. Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment. Nat Immunol. 2016;17:956-65 pubmed publisher
    ..Despite their necessity for Bcl11b expression, these inputs act in a stage-specific manner, providing a multitiered mechanism for developmental gene regulation. ..
  26. Wang X, Lei X, Wang J. Malondialdehyde regulates glucose-stimulated insulin secretion in murine islets via TCF7L2-dependent Wnt signaling pathway. Mol Cell Endocrinol. 2014;382:8-16 pubmed publisher
    ..Both upstream (PI3K and p-AKT) and downstream (TCF7L2 and TCF7) factors of Wnt pathway showed greatest changes. Knockdown of TCF7L2 blocked the MDA-induced GSIS elevation...
  27. Kim J, Choi H, Kim T, Leem S, Oh I. Regulation of mesenchymal stromal cells through fine tuning of canonical Wnt signaling. Stem Cell Res. 2015;14:356-68 pubmed publisher
  28. Zhao W, Li X, Peng Y, Qin Y, Pan J, Li J, et al. Sclerostin Antibody Reverses the Severe Sublesional Bone Loss in Rats After Chronic Spinal Cord Injury. Calcif Tissue Int. 2018;103:443-454 pubmed publisher
    ..of bone marrow cells, Scl-Ab inhibited osteoclastogenesis, and promoted osteoblastogenesis accompanied by increased Tcf7, ENC1, and the OPG/RANKL ratio expression, and decreased SOST expression...
  29. Saha S, Yin Y, Chae H, Cho S. Opposing Regulation of Cancer Properties via KRT19-Mediated Differential Modulation of Wnt/β-Catenin/Notch Signaling in Breast and Colon Cancers. Cancers (Basel). 2019;11: pubmed publisher
    ..catenin but not with RAC1, allowing the LEF/TCF transcription factor to bind primarily to the LEF1 and TCF7 promoter regions, whereas in breast cancer, KRT19 interacted with the β-catenin/RAC1 complex and led to ..
  30. Sade Feldman M, Yizhak K, Bjorgaard S, Ray J, de Boer C, Jenkins R, et al. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 2018;175:998-1013.e20 pubmed publisher
    ..A single transcription factor, TCF7, was visualized within CD8+ T cells in fixed tumor samples and predicted positive clinical outcome in ..
  31. Huang W, Wang P, Shen T, Hu C, Han Y, Song M, et al. Aluminum Trichloride Inhibited Osteoblastic Proliferation and Downregulated the Wnt/?-Catenin Pathway. Biol Trace Elem Res. 2017;177:323-330 pubmed publisher
    ..Taken together, these findings indicated that AlCl3 inhibits osteoblastic proliferation may be associated with the inactivation of Wnt/?-catenin signaling pathway. ..
  32. Karmaus P, Chen X, Lim S, Herrada A, Nguyen T, Xu B, et al. Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity. Nature. 2019;565:101-105 pubmed publisher
  33. Johnson J, Georgakilas G, Petrovic J, Kurachi M, Cai S, Harly C, et al. Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells. Immunity. 2018;48:243-257.e10 pubmed publisher
    ..These results indicate that a mechanism by which TCF-1 controls T cell fate is through its widespread ability to target silent chromatin and establish the epigenetic identity of T cells. ..
  34. Fan M, Xu J, Xiao Q, Chen F, Han X. Long non-coding RNA TCF7 contributes to the growth and migration of airway smooth muscle cells in asthma through targeting TIMMDC1/Akt axis. Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..Nevertheless, the role of lncRNA TCF7 (lncTCF7) in airway smooth muscle cells (ASMCs) is still covered...
  35. Wang Y, Zhang S, Xu Y, Zhang Y, Guan H, Li X, et al. Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 in human osteosarcoma. Tumour Biol. 2016;37:15211-15220 pubmed
    ..Finally, Western blot and Luciferase assays identified TCF7 as a target of miR-192...
  36. Zhang H, Yang J, Liang G, Gao X, Sang Y, Gui T, et al. Andrographolide Induces Cell Cycle Arrest and Apoptosis of Chondrosarcoma by Targeting TCF-1/SOX9 Axis. J Cell Biochem. 2017;118:4575-4586 pubmed publisher
    ..In conclusion, these results highlight the potential therapeutic effects of Andro in treatment of chondrosarcoma via targeting the TCF-1/SOX9 axis. J. Cell. Biochem. 118: 4575-4586, 2017. © 2017 Wiley Periodicals, Inc. ..
  37. Ma J, Wang R, Fang X, Ding Y, Sun Z. Critical role of TCF-1 in repression of the IL-17 gene. PLoS ONE. 2011;6:e24768 pubmed publisher
    ..This TCF-1-mediated repression of IL-17 is critical for peripheral T cells to generate balanced immune responses. ..
  38. Sharma A, Chen Q, Nguyen T, Yu Q, Sen J. T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes. J Immunol. 2012;188:3859-68 pubmed publisher
    ..Thus, TCF1 and β-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus. ..
  39. Pinnell N, Yan R, Cho H, Keeley T, Murai M, Liu Y, et al. The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia. Immunity. 2015;43:870-83 pubmed publisher
    ..In contrast to the Notch cofactor Maml, which is nonselective, Zmiz1 was selective. Thus, targeting the NOTCH1-ZMIZ1 interaction might combat leukemic growth while avoiding the intolerable toxicities of NOTCH inhibitors. ..
  40. Donnarumma T, Young G, Merkenschlager J, Eksmond U, Bongard N, Nutt S, et al. Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus. Cell Rep. 2016;17:1571-1583 pubmed publisher
    ..depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (encoding TCF-1) and by the expression of the inhibitory receptors PD-1 and LAG3...
  41. Ma J, Wang R, Fang X, Sun Z. ?-catenin/TCF-1 pathway in T cell development and differentiation. J Neuroimmune Pharmacol. 2012;7:750-62 pubmed publisher
    ..Therefore, in this review, we will focus on the function of ?-catenin/TCF-1 pathway in the regulation of thymic and peripheral T cell differentiation processes. ..
  42. Cui L, Guan Y, Qu Z, Zhang J, Liao B, Ma B, et al. WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors. J Clin Invest. 2013;123:1647-61 pubmed publisher
    ..The function of WNT signaling is primarily mediated by TCF7, which directly induces expression of Sox2 and Nestin...
  43. Masson F, Minnich M, Olshansky M, Bilic I, Mount A, Kallies A, et al. Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation. J Immunol. 2013;190:4585-94 pubmed publisher
    ..effector differentiation and instead programs CD8(+) T cells to adopt a memory fate with increased Eomesodermin and Tcf7 expression...
  44. Qu L, Li J, Zhao Z, Jiang H, Zhang Q. Differential Expression of miR-202 and Validation of Predicted Target Genes in the Skin Tissue of C57BL/6 Black Mice and BALB/c White Mice. DNA Cell Biol. 2017;36:443-450 pubmed publisher
    ..The expression of miR-202 target genes (wnt5a, kit, and tcf7) was examined by real-time quantitative polymerase chain reaction and western blot in the mouse skin tissue and ..
  45. Li Q, Hua Y, Yang Y, He X, Zhu W, Wang J, et al. T Cell Factor 7 (TCF7)/TCF1 Feedback Controls Osteocalcin Signaling in Brown Adipocytes Independent of the Wnt/β-Catenin Pathway. Mol Cell Biol. 2018;38: pubmed publisher
    ..b>T cell factor 7 (TCF7) belongs to the TCF/LEF1 family of DNA binding factors crucial for the canonical WNT/β-catenin pathway;..
  46. Billingsley J, Rajakumar P, Connole M, Salisch N, Adnan S, Kuzmichev Y, et al. Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling. PLoS Pathog. 2015;11:e1004740 pubmed publisher
    ..over time, while expression of transcription factors associated with quiescence or memory differentiation, such as TCF7, BCOR and EOMES, increased...
  47. Barra M, Richards D, Hofer A, Delacher M, Feuerer M. Premature expression of Foxp3 in double-negative thymocytes. PLoS ONE. 2015;10:e0127038 pubmed publisher
    ..In this study, we surprisingly identify Foxp3+ immature thymocytes at the double-negative (DN) stage in transcription factor 7 (Tcf7)-deficient mice...
  48. Mazzola M, Raheja R, Murugaiyan G, Rajabi H, Kumar D, Pertel T, et al. Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation. J Neuroinflammation. 2015;12:245 pubmed publisher
    ..These results reveal a previously unknown mechanism of the effect of FTY720 on human CD4+ T cell modulation in multiple sclerosis and demonstrate the role of TCF-1 in human T cell activation and effector function. ..
  49. Zheng H, Lin Z, Zhang Y, Zhou C, Liu X, Wu S. [Oxidized low-density lipoprotein modulates differentiation of murine memory CD8+ T cell subpopulations]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1098-1103 pubmed
  50. Wu B, Chen M, Gao M, Cong Y, Jiang L, Wei J, et al. Down-regulation of lncTCF7 inhibits cell migration and invasion in colorectal cancer via inhibiting TCF7 expression. Hum Cell. 2019;32:31-40 pubmed publisher
    ..Long noncoding RNA TCF7 (lncTCF7) has been shown to play critical roles in human CRC development and progression, but the molecular ..
  51. Muranski P, Borman Z, Kerkar S, Klebanoff C, Ji Y, Sanchez Perez L, et al. Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity. 2011;35:972-85 pubmed publisher
    ..In addition, we found that Th17 cells had high expression of Tcf7, a direct target of the Wnt and β-catenin signaling axis, and accumulated β-catenin, a feature observed in ..
  52. Ouyang K, Leandro Gomez Amaro R, Stachura D, Tang H, Peng X, Fang X, et al. Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014;5:4814 pubmed publisher
    ..These data indicate that IP3R-mediated Ca(2+) signalling reinforces Tcf-1 activity to both ensure normal development and prevent thymocyte neoplasia. ..
  53. Hoverter N, Zeller M, McQuade M, GARIBALDI A, Busch A, Selwan E, et al. The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition. Nucleic Acids Res. 2014;42:13615-32 pubmed publisher
    ..Two vertebrate TCFs (TCF-1/TCF7 and TCF-4/TCF7L2) use the C-clamp as an alternatively spliced domain to regulate cell-cycle progression, but how ..
  54. Xu X, Tang X, Guo W, Yang K, Ren T. TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma. Tumour Biol. 2016;37:14129-14140 pubmed
    ..Also, TCF-1 can be of important prognostic value and a promising therapeutic target for DDCS patients. ..
  55. Allan D, Cerdeira A, Ranjan A, Kirkham C, Aguilar O, Tanaka M, et al. Transcriptome analysis reveals similarities between human blood CD3- CD56bright cells and mouse CD127+ innate lymphoid cells. Sci Rep. 2017;7:3501 pubmed publisher
    ..In line with the latter hypothesis, among transcription factors known to impact ILC or NK cell development, GATA3, TCF7 (TCF-1), AHR, SOX4, RUNX2, and ZEB1 transcript levels are higher in CD56bright cells, while IKZF3 (..
  56. Chen Y, Yu D. TCF-1 at the Tfh and Th1 Divergence. Trends Immunol. 2015;36:758-60 pubmed publisher
  57. Yu Q, Sharma A, Oh S, Moon H, Hossain M, Salay T, et al. T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol. 2009;10:992-9 pubmed publisher
    ..Thus, TCF-1 initiates T(H)2 differentiation of activated CD4(+) T cells by promoting GATA-3 expression and suppressing IFN-gamma expression. ..
  58. Zhu P, Xu X, Lin X. Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning. Biol Open. 2015;4:1376-86 pubmed publisher
    ..By interrogating the transcription circuit of foxj1a regulation, we found that both Lef1 and Tcf7 bind to a consensus element in the foxj1a promoter region...
  59. Ma H, Li W, Bi P, Wang Q, Li J, Yang B. hsa-miR-93 regulates MUCIN family gene expression via WNT/β-catenin pathway in intrahepatic stone disease. Clin Res Hepatol Gastroenterol. 2018;42:453-461 pubmed publisher
    ..Then mucins and Wnt pathway proteins were detected by the immunoblotting, and the target gene TCF7 were validated using the dual luciferase assay...
  60. Sharma A, Berga Bolaños R, Sen J. T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development. PLoS ONE. 2014;9:e115803 pubmed publisher
    ..Here we demonstrate that T cell factor (TCF)-1, encoded by the Tcf7 gene, is critical for the extended lifetime of DP thymocytes...
  61. Li P, Hu Y, Yi J, Li J, Yang J, Wang J. Identification of potential biomarkers to differentially diagnose solid pseudopapillary tumors and pancreatic malignancies via a gene regulatory network. J Transl Med. 2015;13:361 pubmed publisher
    ..could correctly differentiate SPN from PanNET, while hsa-miR-204 and 4 TFs such as SOX9, TCF7 and PPARD etc. were demonstrated as the potential markers for SPN versus PDAC...
  62. Ravindranath A, Cadigan K. The Role of the C-Clamp in Wnt-Related Colorectal Cancers. Cancers (Basel). 2016;8: pubmed publisher
    ..Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans...
  63. Rouskas K, Cauchi S, Raverdy V, Yengo L, Froguel P, Pattou F. Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients. Surg Obes Relat Dis. 2014;10:679-83 pubmed publisher
    ..b>Transcription factor 7-like 2 (TCF7 L2) gene variation (rs7903146, C: wild-type allele, T: risk-allele) is the strongest ..
  64. Wu X, Sun X, Chen C, Bai C, Wang X. Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study. Crit Care. 2014;18:508 pubmed publisher
    ..Downregulation of TCF7 in PBMCs was found to be associated with the severity of COPD...
  65. Xu L, Cao Y, Xie Z, Huang Q, Bai Q, Yang X, et al. The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection. Nat Immunol. 2015;16:991-9 pubmed publisher
    ..Thus, TCF-1 functions as an important hub upstream of the Bcl-6-Blimp1 axis to initiate and secure the differentiation of T(FH) cells during acute viral infection. ..
  66. Miron M, Kumar B, Meng W, Granot T, Carpenter D, Senda T, et al. Human Lymph Nodes Maintain TCF-1hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life. J Immunol. 2018;201:2132-2140 pubmed publisher
    ..These findings establish human LN as reservoirs for memory T cells with high capacities for expansion and diverse recognition and important targets for immunotherapies. ..
  67. Wang O, Huang Y, Wu H, Zheng B, Lin J, Jin P. LncRNA LOC728196/miR-513c axis facilitates glioma carcinogenesis by targeting TCF7. Gene. 2018;679:119-125 pubmed publisher
    ..Mechanistic studies further demonstrated that LOC728196 acts as the sponge for miR-513c to upregulate TCF7 expression. We observed a reciprocal inhibition between LOC728196 and miR-513c...
  68. Liu Y, Lin J, Zhai S, Sun C, Xu C, Zhou H, et al. MicroRNA-214 Suppresses Ovarian Cancer by Targeting β-Catenin. Cell Physiol Biochem. 2018;45:1654-1662 pubmed publisher
    ..The expression of β-catenin, Cyclin D1, and c-Myc was suppressed by the overexpression of miR-214. These results suggested that miR-214 may serve as a tumor suppressor of ovarian cancer by targeting the β-catenin pathway. ..
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