TCEB3

Summary

Gene Symbol: TCEB3
Description: transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
Alias: EloA, SIII, SIII p110, TCEB3A, RNA polymerase II transcription factor SIII subunit A1, elongin 110 kDa subunit, elongin-A, transcription elongation factor B alpha subunit, transcription elongation factor B polypeptide 3
Species: human

Top Publications

  1. ncbi Effects of HIV-1 Nef on cellular gene expression profiles
    Syed Shaheduzzaman
    HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biomed Sci 9:82-96. 2002
  2. ncbi Development and application of a thermal desorption method for the analysis of polar volatile organic compounds in workplace air
    R A Hallama
    Institute of Analytical Chemistry, Vienna University of Technology, Austria
    J Chromatogr A 809:47-63. 1998
  3. doi Microarray gene expression profiling of mouse brain mRNA in a model of lithium treatment
    Albert Chetcuti
    Schizophrenia Research Institute, Sydney, New South Wales, Australia
    Psychiatr Genet 18:64-72. 2008
  4. doi ATIII attenuates endotoxemia induced healing impairment in the colon
    Ricarda Diller
    Department of General Surgery, University Hospital of Munster, Germany
    J Surg Res 157:4-13. 2009
  5. pmc Hepatocyte growth factor-stimulated renal tubular mitogenesis: effects on expression of c-myc, c-fos, c-met, VEGF and the VHL tumour-suppressor and related genes
    S C Clifford
    Department of Pathology, University of Cambridge, UK
    Br J Cancer 77:1420-8. 1998
  6. ncbi Painting analysis of meiotic metaphase I configurations of the germ line-limited chromosomes in Acricotopus
    Wolfgang Staiber
    Institute of Genetics, University of Hohenheim, Stuttgart, Germany
    Chromosome Res 10:101-8. 2002
  7. ncbi [Manual and robotic laparoscopic liver resection. Two case-reviews]
    M Ryska
    Chirurgicá klinika 2 LF UK a UVN Praha
    Rozhl Chir 85:511-6. 2006
  8. pmc Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL
    Edwin R Smith
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 105:8575-9. 2008
  9. pmc Molecular cloning of an essential subunit of RNA polymerase II elongation factor SIII
    K P Garrett
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104
    Proc Natl Acad Sci U S A 91:5237-41. 1994
  10. pmc In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development
    Mark Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 24:9911-9. 2004

Research Grants

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. ncbi Effects of HIV-1 Nef on cellular gene expression profiles
    Syed Shaheduzzaman
    HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biomed Sci 9:82-96. 2002
    ..The results indicate that Nef expression can alter the expression of cellular genes and suggest that this alteration in cellular gene expression may serve to optimize the cell to support the subsequent stages of viral replication...
  2. ncbi Development and application of a thermal desorption method for the analysis of polar volatile organic compounds in workplace air
    R A Hallama
    Institute of Analytical Chemistry, Vienna University of Technology, Austria
    J Chromatogr A 809:47-63. 1998
    ..Carbosieve SIII, Carboxen 569, Carbopack B and Tenax TA were used as solid adsorbents...
  3. doi Microarray gene expression profiling of mouse brain mRNA in a model of lithium treatment
    Albert Chetcuti
    Schizophrenia Research Institute, Sydney, New South Wales, Australia
    Psychiatr Genet 18:64-72. 2008
    ..Even after five decades of use, the mood stabilizer lithium continues to be the mainstay of treatment for bipolar disorder in many countries. The mechanism of action for lithium, however, remains unclear...
  4. doi ATIII attenuates endotoxemia induced healing impairment in the colon
    Ricarda Diller
    Department of General Surgery, University Hospital of Munster, Germany
    J Surg Res 157:4-13. 2009
    ..Antithrombin (ATIII) is known to improve the microcirculation in sepsis. We hypothesized that it may also positively influence the healing of the colon anastomoses under endotoxemia...
  5. pmc Hepatocyte growth factor-stimulated renal tubular mitogenesis: effects on expression of c-myc, c-fos, c-met, VEGF and the VHL tumour-suppressor and related genes
    S C Clifford
    Department of Pathology, University of Cambridge, UK
    Br J Cancer 77:1420-8. 1998
    ..conditions for their culture in vitro and used these cells to investigate changes in mRNA levels of the VHL, elongin A, B and C, VEGF, c-myc, c-fos and c-met genes after HGF/SF exposure...
  6. ncbi Painting analysis of meiotic metaphase I configurations of the germ line-limited chromosomes in Acricotopus
    Wolfgang Staiber
    Institute of Genetics, University of Hohenheim, Stuttgart, Germany
    Chromosome Res 10:101-8. 2002
    ..lucidus. In some cases, pairing-like associations between SIII and K4, which is derived from SIII, were observed in metaphases, indicating the possibility of crossover events and ..
  7. ncbi [Manual and robotic laparoscopic liver resection. Two case-reviews]
    M Ryska
    Chirurgicá klinika 2 LF UK a UVN Praha
    Rozhl Chir 85:511-6. 2006
    ..Laparoscopic resection of the liver, compared to other laparoscopic procedures of the abdominal cavity, have become used in a clinical practice only in recent years. No literature data on robotic liver resections are available...
  8. pmc Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL
    Edwin R Smith
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 105:8575-9. 2008
    ..Although ELL and the elongation factor Elongin A have indistinguishable effects on RNA polymerase in vitro, the loss-of-function studies indicate that these ..
  9. pmc Molecular cloning of an essential subunit of RNA polymerase II elongation factor SIII
    K P Garrett
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104
    Proc Natl Acad Sci U S A 91:5237-41. 1994
    A transcription factor designated SIII was recently purified from mammalian cells and shown to regulate the activity of the RNA polymerase II elongation complex...
  10. pmc In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development
    Mark Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 24:9911-9. 2004
    ..Among these are the ELL family, DSIF, and the heterotrimeric elongin complex. Elongin A, the largest subunit of the elongin complex, is the transcriptionally active subunit, while the smaller elongin ..
  11. pmc The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26
    Marie Laure Diebold
    Département de Biologie et Génomique Structurales, IGBMC Institut de Génétique et Biologie Moléculaire et Cellulaire, UDS, CNRS, INSERM, Illkirch Cedex, France
    EMBO J 29:3979-91. 2010
    ..Importantly, the ARM subdomain of Iws1 is conserved in several transcription factors, including TFIIS, Elongin A and Med26...
  12. pmc The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
    A Pause
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:2156-61. 1997
    ..with elongin B and elongin C, two factors that stabilize and activate the transcription elongation factor elongin A. Here, Hs-CUL-2, a member of the recently identified multigene family, the cullins, is shown to specifically ..
  13. ncbi Comparison of nutshell granular activated carbons to commercial adsorbents for the purge-and-trap gas chromatographic analysis of volatile organic compounds
    L H Wartelle
    USDA ARS Southern Regional Research Center, New Orleans, LA 70179, USA
    J Chromatogr A 879:169-75. 2000
    ..hazelnut shells were compared to four commercially available adsorbents, namely, Tenax TA, Carboxen 569, Carbosieve SIII and coconut charcoal for their properties in purge-and-trap analysis...
  14. ncbi Analysis of N-acyl aminonaphthalene sulphonic acid derivatives with potential anti-human immunodeficiency virus activity by thin-layer chromatography and flame ionization detection
    C Madelaine-Dupuich
    Laboratoire des IMRCP, UA CNRS 470, , Toulouse, France
    J Chromatogr A 653:178-80. 1993
    ..These samples were applied to each type SIII Chromarod by a single injection and developed with pure methanol or a methanol-chloroform-ammonium hydroxide (35:55:..
  15. pmc Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog
    K P Garrett
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Proc Natl Acad Sci U S A 92:7172-6. 1995
    ..studies indicate that p18 activates SIII transcriptional activity above a basal level inherent in the SIII p110 and p15 subunits...
  16. ncbi Functional characterization of a mammalian transcription factor, Elongin A
    Takashi Yasukawa
    Department of Functional Genomics, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Biochem Biophys Res Commun 352:237-43. 2007
    b>Elongin A is the transcriptionally active subunit of the Elongin complex that strongly stimulates the rate of elongation by RNA polymerase II (pol II) by suppressing the transient pausing of the polymerase at many sites along the DNA ..
  17. ncbi Comparative analysis of mitochondrial genotype and aging
    J William O Ballard
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, 217B Biology Building, University of New South Wales, Sydney, NSW, Australia 2052
    Ann N Y Acad Sci 1114:93-106. 2007
    ..As expected we observed high divergence among the three distinct mitotypes and greatest mtDNA variability in siII-harboring flies...
  18. ncbi Molecular cloning of DNAs encoding the regulatory subunits of elongin from Saccharomyces cerevisiae and Drosophila melanogaster
    T Aso
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 241:334-40. 1997
    ..protein, which is capable of binding stably to the Elongin BC complex and preventing it from activating Elongin A. Here, we report the molecular cloning of a Saccharomyces cerevisiae genomic DNA encoding Elongin C subunit and ..
  19. doi Validation study of the s classification for melanoma patients with positive sentinel nodes: the Montreal experience
    Rami Younan
    Department of Surgery, Surgical Oncology Unit, University of Montreal Health Center, Montreal, QC, Canada
    Ann Surg Oncol 17:1414-21. 2010
    ..The S classification was described to predict the non-SLN status, hoping to identify a subset of patients who can be spared the CLND. We tried to validate the feasibility and usefulness of this classification...
  20. ncbi [Motor responses of the colon to stimulation of the sacral parasympathetic nucleus neurons]
    A A Dorofeeva
    Ross Fiziol Zh Im I M Sechenova 93:1188-95. 2007
    ..5 ms and frequency 10 Hz. It was shown that the microstimulation of the SPN neurons located within SI-SIII segments of spinal cord induced mainly the excitatory motor responses of all regions of the colon...
  21. pmc Radiographic results of combined Salter innominate and femoral osteotomy in Legg-Calvé-Perthes disease in older children
    Mahzad Javid
    Iran Mehr Hospital, 338 Zafar Avenue, 4th Floor, Tehran, Iran
    J Child Orthop 3:229-34. 2009
    ..The purpose of the study was to evaluate the radiographic outcomes of simultaneous femoral and pelvic osteotomies...
  22. ncbi Using mesoporous silica MCM-41 for in-line enrichment of atmospheric volatile organic compounds
    Tung Min Wu
    Department of Chemistry, National Central University, Chungli 320, Taiwan
    J Chromatogr A 1105:168-75. 2006
    ..Several commercially available microporous carbon molecular sieves, i.e., Carbosieve SIII, Carboxen 1000, Carboxen 1003, and Carbotrap purchased from Supelco, were employed to form either single sorbent ..
  23. ncbi Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array
    C Stocco
    Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois
    Endocrinology 142:4158-61. 2001
    ..cytochrome c oxidase IV, cathepsin H and L, and copper-zinc superoxide dismutase as well as elongation factor SIII, heat shock protein-60 and mitochondrial ATP synthase-D...
  24. pmc The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription
    Hua Zhang
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
    EMBO J 25:4223-33. 2006
    ..These results revealed a mechanism by which the proteasome machinery is recruited in ER-mediated gene transcription. Our experiments also provided evidence implicating SRC coactivators in gene transcription elongation...
  25. pmc Expression of Drosophila melanogaster xanthine dehydrogenase in Aspergillus nidulans and some properties of the recombinant enzyme
    Benjamin Adams
    School of Biological Sciences, University of Sussex, Brighton BN1 9QG, U K
    Biochem J 362:223-9. 2002
    ..Only a very weak "Fe/SIII" signal (g(1,2,3), 2.057, 1.930, 1...
  26. ncbi Unexpected Si:Al effect on the binary mixtures liquid phase adsorption selectivities in faujasite zeolites
    Inge Daems
    Department of Chemical Engineering, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
    J Am Chem Soc 127:11600-1. 2005
    ..The presence of cations on the SIII/SIII' site inside the supercages of NaX causes a more difficult hosting of benzene inside the supercages of NaX and ..
  27. doi Anti-platelet effect of cumanastatin 1, a disintegrin isolated from venom of South American Crotalus rattlesnake
    Manuel Da Silva
    Laboratorio de Fisiopatologia, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 20632, Caracas 1020, Venezuela
    Thromb Res 123:731-9. 2009
    ..Crude venom and SIII fraction significantly diminished platelet adhesion to fibrinogen (Fg) and to fibronectin (Fn)...
  28. doi Evaluation of adsorbents for volatile methyl siloxanes sampling based on the determination of their breakthrough volume
    L Lamaa
    Universite Lyon 1, CNRS, UMR 5256, IRCELYON, Institut de Recherches sur la Catalyse et l Environnement de Lyon, 2 avenue Albert Einstein, F 69626 Villeurbanne, France Conseil National de la Recherche Scientifique, Commission Libanaise de l Energie Atomique, Laboratoire d analyse de Pesticides et de Polluants Organiques, B P 11 8282, Riad El Solh, 1107 2260 Beyrouth, Lebanon Electronic address
    Talanta 115:881-6. 2013
    ..44 L g(-1) which can contribute to an underestimation in concentration during their quantification. Carbosieve SIII usually used for C2-C5, did not adsorb light VMS as it was expected, and breakthrough volume obtained for VMS are ..
  29. ncbi Characteristics of sensori-motor interaction in the primary and secondary somatosensory cortices in humans: a magnetoencephalography study
    T Wasaka
    Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, 444 8585, Japan
    Neuroscience 149:446-56. 2007
    ..was activated following unilateral stimulation, we analyzed SIIc (contralateral to stimulation) as well as SIIi (ipsilateral to stimulation)...
  30. ncbi Sentinel lymphonodectomy and s-classification: a successful strategy for better prediction and improvement of outcome of melanoma
    Hans Starz
    Department of Dermatology and Allergology, Klinikum Augsburg, Augsburg, Germany
    Ann Surg Oncol 11:162S-8S. 2004
    ..b>SIII metastases, defined by a depth of invasion (d) greater than 1 mm below the capsular level, imply a risk of more ..
  31. ncbi [Soluble interleukin 2 receptor (SIL-2R) in bronchoalveolar lavage fluid (BALF) of patients with sarcoidosis and atopic bronchial asthma]
    Renata Jankowska
    Katedra i Klinika Chorób Płuc AM, Wrocławiu
    Pneumonol Alergol Pol 70:347-52. 2002
    ..Significantly lower level of sII-2R in BALF was observed in patients with AO in comparison to S, SII and NAS (p < 0.005). We didn't find significant differences in sIL-2R levels between AO and SI, SIII, AS.
  32. ncbi S-classification of sentinel lymph node predicts axillary nonsentinel lymph node status in patients with breast cancer
    Astrid Maria Fink
    Department of Dermatology, Wilhelminenspital, Montleartstrasse 37, 1160, Vienna, Austria
    Ann Surg Oncol 15:848-53. 2008
    ..The aim of the present study was to identify patients with positive SN who are unlikely to have further metastases in the axillary lymph node basin, using a new classification of SN, namely the S-classification...
  33. ncbi Measurement of toxic volatile organic compounds in indoor air of semiconductor foundries using multisorbent adsorption/thermal desorption coupled with gas chromatography-mass spectrometry
    Chien Hou Wu
    Department of Atomic Science, National Tsing Hua University, Hsinchu 300, Taiwan
    J Chromatogr A 996:225-31. 2003
    ..factories were collected each hour on multisorbent tubes (including Carbopack B, Carbopack C, and Carbosieve SIII) with a 24-h automatic active sampling system and analyzed using adsorption/thermal desorption coupled with gas ..
  34. ncbi Deranged hypothetical proteins Rik protein, Nit protein 2 and mitochondrial inner membrane protein, Mitofilin, in fetal Down syndrome brain
    J K Myung
    Department of Pediatrics, Division of Neonatology, University of Vienna, Wahringer Gurtel 18, A 1090 Vienna, Austria
    Cell Mol Biol (Noisy-le-grand) 49:739-46. 2003
    ..6 kDa and Elongin A were comparable between groups...
  35. ncbi Sympatric Drosophila simulans flies with distinct mtDNA show difference in mitochondrial respiration and electron transport
    Subhash D Katewa
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia
    Insect Biochem Mol Biol 37:213-22. 2007
    ..respiration, proton leak and electron transport of Drosophila simulans males with distinct mtDNA haplogroups (siII and -III) that were collected in sympatry in Kenya...
  36. ncbi Elongin from Saccharomyces cerevisiae
    C M Koth
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8
    J Biol Chem 275:11174-80. 2000
    ..elongation factor that was first identified in mammalian systems and is composed of the three subunits, elongin A, B, and C...
  37. pmc The Role of Elongin BC-Containing Ubiquitin Ligases
    Fumihiko Okumura
    Division of Biological Science, Graduate School of Science, Nagoya University Nagoya, Aichi, Japan
    Front Oncol 2:10. 2012
    ..The Elongin BC complex enhances the transcriptional activity of Elongin A. "Classical" SOCS box-containing proteins interact with the Elongin BC complex and have ubiquitin ligase ..
  38. pmc Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens
    Christopher D O Cooper
    Nuffield Department of Clinical Laboratory Sciences, Oxford NIHR Biomedical Research Centre, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 6:e23916. 2011
    ..b>TCEB3, BECN1, and two previously uncharacterised proteins, c14orf93 and ZBTB44, were preferentially recognised by ..
  39. doi Prediction of additional lymph node positivity and clinical outcome of micrometastases in sentinel lymph nodes in cutaneous melanoma: a multi-institutional study of 450 patients in Japan
    Kenjiro Namikawa
    Department of Dermatology, National Cancer Center Hospital, Tokyo, Japan
    J Dermatol 39:130-7. 2012
    ..3 mm, sii >0.3 to ≤ 1.0 mm, siii >1...
  40. pmc Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein
    A Pause
    Molecular Oncology Group, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 96:9533-8. 1999
    ..Thus, it seems possible that pVHL/elongin BC/hCUL-2 complex will possess ubiquitin ligase activity targeting specific proteins for degradation by the proteasome...
  41. doi A new double-tracer gas single-breath washout to assess early cystic fibrosis lung disease
    Florian Singer
    Division of Respiratory Medicine, Dept of Paediatrics, University Hospital of Bern, Bern, Switzerland
    Eur Respir J 41:339-45. 2013
    ..3% helium was applied during one tidal breath. Outcomes were SBW phase III slope (SIII(DTG)), MBNW-derived lung clearance index (LCI), and indices of acinar (S(acin)) and conductive (S(cond)) ..
  42. ncbi Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation
    Marlyse A Debrincat
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Biol Chem 282:4728-37. 2007
    ..The targeting of CKB for degradation by Asb-9 was primarily SOCS box-dependent and suggests that Asb-9 acts as a specific ubiquitin ligase regulating levels of this evolutionarily conserved enzyme...
  43. ncbi Assessment of left ventricular hypertrophy in patients with essential hypertension. A rational basis for the electrocardiogram
    P V Fragola
    Department of Internal Medicine, School of Cardiovascular Diseases, II University of Rome, Italy
    Am J Hypertens 6:164-9. 1993
    ..In the whole group the Lewis index ((RI - RIII)+(SIII - SI) > or = 17 mm) showed a slight superiority in diagnosing LVH (sensitivity = 43%) in comparison to the ..
  44. ncbi Extracorporeal membrane oxygenation as a platform for recovery: a case report of a child with pulmonary hemorrhage, refractory hypoxemic respiratory failure, and new onset goodpasture syndrome
    Abdallah Dalabih
    Department of Pediatrics, Division of Pediatric Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Extra Corpor Technol 44:75-7. 2012
    ..VV ECMO was performed with an SIII Sorin roller head pump with integrated servo regulator and a Quadrox D Bioline coated oxygenator...
  45. doi Naturally occurring mitochondrial DNA haplotypes exhibit metabolic differences: insight into functional properties of mitochondria
    Nicolas Pichaud
    Laboratoire de Biologie Intégrative, Departement de Biologie, Universite du Quebec a Rimouski, 300 Allee des Ursulines, Rimouski, Quebec, Canada G5L 3A1
    Evolution 66:3189-97. 2012
    ..In this study, we determined the differences in catalytic properties of mitochondria dictated by divergences in the siII and siIII haplogroups of Drosophila simulans using introgressions of siII mtDNA type into the siIII nuclear ..
  46. doi Mitochondrial haplotype divergences affect specific temperature sensitivity of mitochondrial respiration
    Nicolas Pichaud
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia
    J Bioenerg Biomembr 45:25-35. 2013
    ..simulans fly lines harboring the siII and siIII haplotypes in a common nuclear genetic background...
  47. doi The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathway
    Hiroshi Kanno
    Department of Neurosurgery, Yokohama City University School of Medicine, Yokohama, Japan
    Int J Oncol 42:881-6. 2013
    ..and neurospheres in soft agar, capacity for implantation into SCID mice and expression of CD133, STAT3, JAK2, Elongin A, PTEN and VHL...
  48. pmc Specific binding of antigen onto human T lymphocytes
    A Durandy
    J Clin Invest 77:1557-64. 1986
    ..did not bind [3H]mannan, and that mannan-specific blast cells did not bind tritiated pneumococcal polysaccharide SIII, indicate the specificity of mannan binding. Mannan binding was reversible and saturable...
  49. doi Aging-related decline in somatosensory inhibition of the human cerebral cortex
    Chia Hsiung Cheng
    Institute of Brain Science, National Yang Ming University, Taipei 112, Taiwan
    Exp Brain Res 226:145-52. 2013
    ..Based on equivalent current dipole modeling, PPS ratios of the contralateral (SIIc) and ipsilateral (SIIi) secondary somatosensory cortices were higher in elderly than in young subjects (p < 0.001 in SIIc and p = 0...
  50. ncbi The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C
    C S Brower
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 274:13629-36. 1999
    ..BC complex, which was originally identified as a positive regulator of RNA polymerase II elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau tumor suppressor and suppressor of ..
  51. pmc Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif
    Xiaodan Wang
    National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University, Changchun, Jilin Province, People s Republic of China
    Retrovirology 10:94. 2013
    ..EloB and EloC were initially reported as positive regulatory subunits of the Elongin (SIII) complex...
  52. ncbi cDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs
    H Chen
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Genomics 27:389-98. 1995
    ..search revealed that Ocp2 shares significant sequence similarity with p15, a subunit of transcription factor SIII that regulates the activity of the RNA polymerase II elongation complex...
  53. ncbi Triboelectric charging and dissipation characteristics of the Maquet Quadrox-D membrane oxygenator
    Melissa S Alberts
    University of lowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Extra Corpor Technol 41:105-9. 2009
    ..A Quadrox-D oxygenator was evaluated using a Stockert SIII pump head, Cincinnati subzero H/E, and a custom adult extracorporeal membrane oxygenation tubing pack with 1/2" PVC ..
  54. ncbi The influence of intermittent forces during daytime application of the SIII appliance
    Christian Sander
    Department of Orthodontics, University of Ulm, Germany
    J Orofac Orthop 65:237-45. 2004
    Daytime application of the SIII appliance results in mainly intermittent forces. Permanent force occurs only for a few minutes, if at all. These intermittent forces may be as high as 40 N in individual cases...
  55. ncbi Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A
    K Miyata
    Department of Functional Genomics, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi, Japan
    Cell Death Differ 14:716-26. 2007
    b>Elongin A is a transcription elongation factor that increases the overall rate of mRNA chain elongation by RNA polymerase II. To gain more insight into the physiological functions of Elongin A, we generated Elongin A-deficient mice...
  56. ncbi [Surgical management of intrahepatic cholelithiasis--two case reviews]
    V Visokai
    Chirurgická klinika FTN Praha a 1 LF UK
    Rozhl Chir 86:370-5. 2007
    ..The commonest signs include: cholangoitis, obstruction icterus, liver absces and secondary biliary cirrhosis. Although a wide range of treatment methods is available, in some cases, surgical management is the only alternative...
  57. ncbi [Thyroid carcinoma. A descriptive retrospective study]
    Carolina C Gonzalez
    Servicio de Endocrinologia, Hospital Privado de Cordoba, Naciones Unidas 346, 5016 Cordoba, Argentina
    Medicina (B Aires) 66:526-32. 2006
    ..Papillary thyroid carcinoma (PTC) in 96%. The 63% was SI; 14% SII; 19% SIII and 4% SIV...
  58. pmc Sympatric Drosophila simulans flies with distinct mtDNA show age related differences in mitochondrial metabolism
    Subhash D Katewa
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia
    Insect Biochem Mol Biol 37:923-32. 2007
    ..For this study we have used flies harboring distinct siII and siIII mtDNA types...
  59. ncbi Mitochondrial DNA variation is associated with measurable differences in life-history traits and mitochondrial metabolism in Drosophila simulans
    J William O Ballard
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia
    Evolution 61:1735-47. 2007
    ..c oxidase genes show that there are 76 synonymous and two nonsynonymous fixed differences among flies harboring siII compared with siIII mtDNA...
  60. doi Structural and thermodynamic study on short metal alkanoates: lithium propanoate and pentanoate
    F J Martínez Casado
    E S R F BM16, 38043 Grenoble, France
    J Phys Chem B 113:12896-902. 2009
    ..1 +/- 0.5) K. For lithium pentanoate, two solid-to-solid transitions (SIII-SII and SII-SI), at T(ss) = (205.5 +/- 0.5) K and T(ss) = (325.2 +/- 0...
  61. ncbi Assessment of air pollution tolerance index of some trees in Moradabad city, India
    Anamika Tripathi
    Ecology Research Laboratory, Departmentof Botany, Hindu College, Moradabad 244 001, India
    J Environ Biol 30:545-50. 2009
    ..Azadirachta indica and Grewelia robusta was taken from residential (SI), industrial (SII) and commercial (SIII) area of the city as this florais very much common to the Brass city and is planted on the roadside...
  62. doi Thermal sensitivity of mitochondrial metabolism in two distinct mitotypes of Drosophila simulans: evaluation of mitochondrial plasticity
    Nicolas Pichaud
    Laboratoire de Biologie Intégrative, Departement de Biologie, Universite du Quebec a Rimouski, 300 Allee des Ursulines, Rimouski, Quebec, Canada, G5L 3A1
    J Exp Biol 213:1665-75. 2010
    ..of temperature of mitochondrial respiration and several key enzymes of mitochondrial metabolism in two mitotypes (siII and siIII) of Drosophila simulans...
  63. doi The TFIIS and TFIIS-like genes from Medicago truncatula are involved in oxidative stress response
    Anca Macovei
    Dipartimento di Genetica e Microbiologia, Via Ferrata 1, 27100 Pavia, Italy
    Gene 470:20-30. 2011
    ..by highly conserved leucine (L) and tryptophan (W) residues, also found in the canonical TFIIS protein, elongin A (transcription elongation factor S-III) and CRSP70 (cofactor required for Sp1 activation), while a proline-rich ..
  64. pmc Multiple hybridization events between Drosophila simulans and Drosophila mauritiana are supported by mtDNA introgression
    Maria D S Nunes
    Institut für Populationsgenetik, Veterinärmedizinische Universität Wien, Vienna, Austria
    Mol Ecol 19:4695-707. 2010
    ..These haplotypes diverged quite recently from haplotypes of the siII group present in cosmopolitan populations of D. simulans...
  65. ncbi Influence of moisture content and temperature on the dielectric permittivity of zeolite NaY
    Markus Kraus
    Helmholtz Centre for Environmental Research UFZ, Department of Environmental Engineering, Permoserstr 15, 04318 Leipzig, Germany
    Phys Chem Chem Phys 13:4119-25. 2011
    ..activation energy of the cations on SII sites, cations in the zeolite NaY are moving from SII sites to unoccupied SIII sites when the water content is increasing...
  66. pmc An examination of somatosensory area SIII in ferret cortex
    W Alex Foxworthy
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Somatosens Mot Res 28:1-10. 2011
    ..are consistent with previous work in ferrets as well as with the location, physiology, and connectivity of area SIII in cats...
  67. doi Involvement of the sacral parasympathetic nucleus in the innervation of the descending colon and rectum in cats
    A A Dorofeeva
    Corticovisceral Physiology Laboratory, St Petersburg, Russia
    Neurosci Behav Physiol 39:207-10. 2009
    ..receive innervation from neurons in the sacral parasympathetic nucleus located in spinal cord segments SI, SII, and SIII. The largest number of labeled cells was seen in segment SII...
  68. pmc Ameliorative Effect of Active Principle Isolated from Seeds of Eugenia jambolana on Carbohydrate Metabolism in Experimental Diabetes
    Suman Bala Sharma
    Department of Biochemistry, University College of Medical Sciences, University of Delhi, Delhi 110095, India
    Evid Based Complement Alternat Med 2011:789871. 2011
    ..Ethanolic extract upon chromatographic purification yielded partially purified hypoglycemic principle (SIII) which on further purification by sephadex LH 20 yielded pharmacological active compound LH II...
  69. pmc Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1
    Takashi Yasukawa
    Department of Functional Genomics, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    EMBO J 27:3256-66. 2008
    ..degradation of the largest subunit of pol II (Rpb1) following UV-irradiation are significantly suppressed in Elongin A-deficient cells; however, in both cases suppression is rescued by transfection of wild-type Elongin A...
  70. ncbi [DDP-sensitivity-related genes in 10 lung cancer cell lines]
    Chun Hong Li
    Internal Medicine Department, Third Affiliated Hospital, Harbin Medical University, China
    Zhonghua Zhong Liu Za Zhi 30:418-21. 2008
    ..To search for genes related to cisplatin (DDP) sensitivity in small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) cell lines...
  71. doi Hemolysis during cardiac extracorporeal membrane oxygenation: a case-control comparison of roller pumps and centrifugal pumps in a pediatric population
    Jonathan Byrnes
    Department of Pediatrics Section of Critical Care, University of Arkansas Medical Sciences, Little Rock, Arkansas, USA
    ASAIO J 57:456-61. 2011
    ..ECMO with Levitronix Centrimag (Centrimag group [CG]) were matched to 14 patients supported with Stockert-Shiley SIII (Stockert-Shiley group [SSG]) at a single institution from July 2007 to July 2009...
  72. ncbi [Optimization of use of prehospital emergency physicians after new dispatch and guidance instructions]
    Michael Kanstrup Dahl
    Region Nordjylland
    Ugeskr Laeger 170:1629-33. 2008
    ..Based on the severity gauge Severity of Injury/Illness Index (SIII) which grades injury/illness into eight levels, we examined the effect of implementing new dispatch and guidance ..
  73. doi Common structural features characterize interstitial intrachromosomal Xp and 18q triplications
    Roberto Giorda
    Istituto Scientifico E Medea, Bosisio Parini LC, Italy
    Am J Med Genet A 155:2681-7. 2011
    ..located within complex segmental duplications, one containing the VCX gene cluster on chromosome Xp, the other the TCEB3 genes on chromosome 18q. A proximal duplicated region is also present in both patients...
  74. ncbi Phytoplankton as index of water quality with reference to industrial pollution
    T R Shashi Shekhar
    Department of Chemistry, East West Institute of Technology, Bangalore, India
    J Environ Biol 29:233-6. 2008
    In this paper Shannon-Weaver (SI-3.58-4.07, SII-3.1-3.72, SIII-1.64-2.25, SIV-2.54-2.95 and SV-3.09-3...
  75. ncbi Grading as a prognostic factor: review of 209 primary gastric cancer patients
    G B Secco
    Cattedra di Semeiotica Chirurgica B, Genova, Italy
    Tumori 75:494-7. 1989
    ..All patients were followed up for a minimum of 5 years. There were 25 SI cases (12%), 22 SII (10.5%), 55 SIII (26.3%) and 107 SIV (51.2%). Tumor grade according to Broders classification showed 50 cases of G1 lesions (23...
  76. ncbi Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development
    S C Clifford
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Birmingham, U K
    Genes Chromosomes Cancer 26:20-8. 1999
    ..VHL forms a multimeric complex with two subunits (B and C) of the SIII (elongin) transcriptional elongation complex and CUL2, a member of the cullin family...
  77. pmc Geographic distribution and inheritance of three cytoplasmic incompatibility types in Drosophila simulans
    C Montchamp-Moreau
    CNRS UA 693 Dynamique du Génome et Evolution, Universite Paris VI, France
    Genetics 129:399-407. 1991
    ..Both W and R types were found among mainland and island populations harboring the worldwide mitochondrial type SiII. Type S incompatibility could be involved in the reinforcement of the geographical isolation of SiI populations.
  78. ncbi Separation of paralytic shellfish poisoning toxins on Chromarods-SIII by thin-layer chromatography with the Iatroscan (mark 5) and flame thermionic detection
    W M Indrasena
    Canadian Institute of Fisheries Technology, Department of Food Science and Technology, DalTech, Dalhousie University, Halifax, Nova Scotia, Canada
    J Chromatogr A 855:657-68. 1999
    Thin-layer chromatography (TLC) on Chromarods-SIII with the Iatroscan (Mark-5) and a flame thermionic detector (FTID) was used to develop a rapid method for the detection of paralytic shellfish poisoning (PSP) toxins...
  79. ncbi Structural organization and chromosome location of the mouse elongin A gene (Tceb3)
    T Aso
    Department of Viral Oncology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Cytogenet Cell Genet 86:259-62. 1999
    b>Elongin A is the transcriptionally active subunit of the Elongin complex, which strongly increases the rate of elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites within transcription ..
  80. pmc Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein
    M Ohh
    Department of Adult Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 104:1583-91. 1999
    ..These results are consistent with the view that diminished binding of pVHL to the elongins plays a causal role in VHL disease...
  81. ncbi Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis
    T Aso
    Department of Viral Oncology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 170 8455, Japan
    J Biol Chem 275:6546-52. 2000
    ..B and C subunits, the latter of which bind stably to each other to form a binary complex that interacts with Elongin A and strongly induces its transcriptional activity...
  82. ncbi Novel roles for elongin C in yeast
    T Jackson
    Department of Biochemistry SL43, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, USA
    Biochim Biophys Acta 1491:161-76. 2000
    Mammalian Elongin C is a 112-amino acid protein that binds to the von Hippel-Lindau (VHL) tumor suppressor and to Elongin A, the transcriptionally active subunit of the RNA polymerase II elongation factor, SIII...
  83. ncbi Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70
    V Booth
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 275:31266-8. 2000
    ..Domain I is conserved in evolution from yeast to human species and is homologous to the transcription factors elongin A and CRSP70...
  84. pmc Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C
    M V Botuyan
    Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 96:9033-8. 1999
    Elongin is a heterotrimeric transcription elongation factor composed of subunits A, B, and C in mammals. Elongin A and C are F-box-containing and SKP1 homologue proteins, respectively, and are therefore of interest for their potential ..
  85. ncbi Expression of the von Hippel-Lindau-binding protein-1 (Vbp1) in fetal and adult mouse tissues
    M Hemberger
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin Dahlem, Germany, Fakultät für Biologie III, Universitat Freiburg, Freiburg, Germany
    Hum Mol Genet 8:229-36. 1999
    ..of transcriptional elongation by preventing the association of elongin B and C with the catalytic subunit elongin A. Alterations in the human VHL gene lead to VHL disease which is associated with various rare neoplasias, ..
  86. pmc The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
    T Kamura
    Howard Hughes Medical Institute HHMI, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104 USA
    Genes Dev 12:3872-81. 1998
    ..BC complex was identified initially as a positive regulator of RNA polymerase II (Pol II) elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau (VHL) tumor suppressor complex, in which ..
  87. ncbi Inhibition of transcription elongation by the VHL tumor suppressor protein
    D R Duan
    Urologic Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 269:1402-6. 1995
    ..Here, a cellular transcription factor, Elongin (SIII), is identified as a functional target of the VHL protein...
  88. ncbi A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII
    K P Garrett
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation Oklahoma City 73104
    Gene 150:413-4. 1994
    A full-length cDNA encoding a human homolog of the 15-kDa subunit (p15) of RNA polymerase II elongation factor SIII was isolated and sequenced...
  89. ncbi A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin
    T Aso
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Gene 168:277-8. 1996
    A full-length cDNA encoding a human homolog of the approx. 110-kDa subunit (elongin A; El A) of the RNA polymerase II transcription factor, elongin, was isolated and sequenced...
  90. ncbi Early neurogenesis of the Drosophila brain
    A Younossi-Hartenstein
    Department of Cellular Molecular and Developmental Biology, University of California Los Angeles 90024, USA
    J Comp Neurol 370:313-29. 1996
    ..b>SIII neuroblasts (Pa1-4, Pp1-2, Dp2) arise during stage 10, SIV neuroblasts (Pa5-6, Pp3-4, Da1, T1-2) during early stage ..
  91. ncbi Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3
    S P DiMarco
    Howard Hughes Medical Institute, Emory University School of Medicine, Atlanta, Georgia, 30322, USA
    Genomics 36:185-8. 1996
    ..3. Since another elongation factor, SIII, has been implicated in human carcinogenesis and since the interval within which the human SII gene maps is ..
  92. pmc The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex
    T Aso
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    EMBO J 15:5557-66. 1996
    ..small regulatory B and C subunits, which bind stably to each other to form a binary complex that interacts with elongin A and strongly induces its transcriptional activity...
  93. ncbi Nonrandom partition of mitochondria in heteroplasmic Drosophila
    E De Stordeur
    Laboratoire de Zoogéographie, Universite Paul Valery, Montpellier, France
    Heredity (Edinb) 79:615-23. 1997
    ..microinjections between eggs were performed involving three lineages of Drosophila simulans, carrying the siI, siII or siIII mtDNA type, respectively, and two strains of Drosophila mauritiana carrying the maI or maII mtDNA type...
  94. ncbi Factors regulating the transcriptional elongation activity of RNA polymerase II
    A Shilatifard
    Department of Biochemistry, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    FASEB J 12:1437-46. 1998
    ..Shilatifard, A. Factors regulating the transcriptional elongation activity of RNA polymerase II...
  95. ncbi Muscle cross-sectional area is associated with specific site of bone in prepubertal girls: a quantitative magnetic resonance imaging study
    A Heinonen
    School of Human Kinetics, University of British Columbia, Vancouver, Canada
    Bone 29:388-92. 2001
    ..The tibial cross-sectional areas were subdivided into three anatomical sectors (SI-SIII), with the tibial centroid as origin...
  96. pmc A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes
    Liora Z Strichman-Almashanu
    Department of Medicine, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Genome Res 12:543-54. 2002
    ..At least two gDMRs mapped near imprinted genes, HYMA1 and a novel homolog of Elongin A and Elongin A2, which we term Elongin A3...
  97. pmc The RNA polymerase II general elongation factors
    D Reines
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Trends Biochem Sci 21:351-5. 1996
    ..To date, five general elongation factors [P-TEFb, SII, TFIIF, Elongin (SIII) and ELL] have been defined biochemically...
  98. pmc Differential fitness of mitochondrial DNA in perturbation cage studies correlates with global abundance and population history in Drosophila simulans
    J William O Ballard
    Department of Biological Science, University of Iowa, Iowa City, IA 52242, USA
    Proc Biol Sci 271:1197-201. 2004
    ..have a significant and repeatable effect on the frequency of flies with specific genotypes in population cages (siII > -III > -I) and that coadapted mitonuclear interactions are greatest in the siI type...
  99. ncbi Cryogenic trapping for determination of odor concentration
    J Masuda
    Osaka City Institute of Public Health and Environmental Sciences, Tojo cho 8 34, Tennoji ku, Osaka 543 0026, Japan
    Water Sci Technol 50:121-4. 2004
    ..To measure odor below the limit, a condensing procedure using solid sorbents (Tenax-TA, Unicarbon B and Carbosieve SIII) has been developed and used in Japan...
  100. pmc Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53
    Paola Blanchette
    McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 24:9619-29. 2004
    ..Here we show that, like other elongin BC-interacting proteins, including elongin A, von Hippel-Lindau protein, and Muf1, the interaction of E4orf6 is mediated by the BC-box motif; however, E4orf6 ..
  101. ncbi Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A
    Mark Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Health Sciences Center, Saint Louis, Missouri 63104, USA
    J Biol Chem 280:4017-20. 2005
    The elongation stage of transcription by RNA polymerase II (Pol II) has emerged as an essential regulated step. Elongin A (EloA) is the largest subunit of the Elongin complex that can increase the catalytic rate of mRNA synthesis by Pol ..

Research Grants8

  1. RNA POLYMERASE II ELONGATION COMPLEX STRUCTURE/FUNCTION
    Daniel Reines; Fiscal Year: 1999
    ..Specific elongation factors improve the efficiency of RNA chain synthesis. Two such factors, TFIIF and SIII (elongin), are implicated in human diseases including cancer, demonstrating that perturbation of transcript ..
  2. BIOCHEMISTRY OF EUKARYOTIC MESSENGER RNA SYNTHESIS
    RONALD C contact CONAWAY; Fiscal Year: 2010
    ..organized along the following lines: (1) Further analysis of the mechanism of action of Pol II elongation factor Elongin A and of its newly described role in UV-induced ubiquitination of Pol II...
  3. MECHANISM OF ACTIVITIES OF TAT AND REV OF HIV1
    PHILLIP SHARP; Fiscal Year: 2001
    ..The laboratory has also shown that the pol II elongation factor SIII increases polymerase processivity, and reduces Tat activation, suggesting that Tat may function through ..
  4. Drosophila simulans as a model for aging research
    John Ballard; Fiscal Year: 2002
    ..simulans has the potential to be a robust, heuristic model with respect to delineation of the mechanisms by which inherited mtDNA variants given rise to observed variation in rates of aging in humans. ..
  5. EVOLUTIONARY GENETICS OF MALE REPRODUCTIVE TRAITS IN MUS
    MATTHEW DEAN; Fiscal Year: 2006
    ..These studies will help uncover the genetic basis of male reproductive fitness in a natural population of house mice. ..