TBX5

Summary

Gene Symbol: TBX5
Description: T-box 5
Alias: HOS, T-box transcription factor TBX5, T-box protein 5
Species: human
Products:     TBX5

Top Publications

  1. Akrami S, Winter R, Brook J, Armour J. Detection of a large TBX5 deletion in a family with Holt-Oram syndrome. J Med Genet. 2001;38:E44 pubmed
  2. Huang T, Lock J, Marshall A, Basson C, Seidman J, Seidman C. Causes of clinical diversity in human TBX5 mutations. Cold Spring Harb Symp Quant Biol. 2002;67:115-20 pubmed
  3. Borozdin W, Bravo Ferrer Acosta A, Bamshad M, Botzenhart E, Froster U, Lemke J, et al. Expanding the spectrum of TBX5 mutations in Holt-Oram syndrome: detection of two intragenic deletions by quantitative real time PCR, and report of eight novel point mutations. Hum Mutat. 2006;27:975-6 pubmed
    Mutations in the gene TBX5 cause Holt-Oram syndrome (HOS), an autosomal dominant disorder characterized by anterior (i.e., radial ray) upper limb malformations and congenital heart defects and/or cardiac conduction anomalies...
  4. Pfeufer A, van Noord C, Marciante K, Arking D, Larson M, Smith A, et al. Genome-wide association study of PR interval. Nat Genet. 2010;42:153-9 pubmed publisher
    ..Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes...
  5. Holm H, Gudbjartsson D, Arnar D, Thorleifsson G, Thorgeirsson G, Stefansdottir H, et al. Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet. 2010;42:117-22 pubmed publisher
    ..6 x 10(-7)). We identified one locus for heart rate (MYH6), four for PR interval (TBX5, SCN10A, CAV1 and ARHGAP24) and four for QRS duration (TBX5, SCN10A, 6p21 and 10q21)...
  6. Li Q, Newbury Ecob R, Terrett J, Wilson D, Curtis A, Yi C, et al. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat Genet. 1997;15:21-9 pubmed
    ..We have now identified a gene for this disorder (HOS1). The gene (TBX5) is a member of the Brachyury (T) family corresponding to the mouse Tbx5 gene...
  7. Basson C, Bachinsky D, Lin R, Levi T, Elkins J, Soults J, et al. Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet. 1997;15:30-5 pubmed
    ..Here, we demonstrate that mutations in the human TBX5 gene underlie this disorder. TBX5 was cloned from the disease locus on human chromosome 12q24...
  8. Hatcher C, Goldstein M, Mah C, Delia C, Basson C. Identification and localization of TBX5 transcription factor during human cardiac morphogenesis. Dev Dyn. 2000;219:90-5 pubmed
    Mutations in the TBX5 transcription factor gene cause human cardiac malformation in Holt-Oram syndrome...
  9. Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, et al. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet. 2001;28:276-80 pubmed
    ..Using the yeast two-hybrid system with Nkx2-5 as the 'bait', we isolated the T-box-containing transcription factor Tbx5; mutations in TBX5 cause heart and limb malformations in Holt-Oram syndrome (HOS)...

More Information

Publications115 found, 100 shown here

  1. Fan C, Liu M, Wang Q. Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome. J Biol Chem. 2003;278:8780-5 pubmed
    b>TBX5 is a T-box transcription factor that plays a critical role in organogenesis...
  2. Garg V, Kathiriya I, Barnes R, Schluterman M, King I, Butler C, et al. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature. 2003;424:443-7 pubmed
    ..Furthermore, the Gata4 mutation abrogated a physical interaction between Gata4 and TBX5, a T-box protein responsible for a subset of syndromic cardiac septal defects...
  3. Zaragoza M, Lewis L, Sun G, Wang E, Li L, Said Salman I, et al. Identification of the TBX5 transactivating domain and the nuclear localization signal. Gene. 2004;330:9-18 pubmed
    b>TBX5 is a member of the T-box gene family and encodes a transcription factor involved in cardiac and limb development...
  4. Reamon Buettner S, Borlak J. TBX5 mutations in non-Holt-Oram syndrome (HOS) malformed hearts. Hum Mutat. 2004;24:104 pubmed
    The T-box transcription factor Tbx5 is important in mammalian cardiac development. Mutations in the human TBX5 gene cause Holt-Oram syndrome (HOS), a disorder characterized by heart and upper limb deformities...
  5. McDermott D, Bressan M, He J, Lee J, Aftimos S, Brueckner M, et al. TBX5 genetic testing validates strict clinical criteria for Holt-Oram syndrome. Pediatr Res. 2005;58:981-6 pubmed
    ..syndrome characterized by congenital heart disease (CHD) and upper limb deformity, and caused by mutations in the TBX5 gene. To date, the sensitivity of TBX5 genetic testing for HOS has been unclear...
  6. Murakami M, Nakagawa M, Olson E, Nakagawa O. A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Natl Acad Sci U S A. 2005;102:18034-9 pubmed
    The T-box transcription factor TBX5 plays essential roles in cardiac and limb development...
  7. Zhu Y, Gramolini A, Walsh M, Zhou Y, Slorach C, Friedberg M, et al. Tbx5-dependent pathway regulating diastolic function in congenital heart disease. Proc Natl Acad Sci U S A. 2008;105:5519-24 pubmed publisher
    ..Haploinsufficiency of the T-box transcription factor Tbx5 in mouse and man causes congenital heart defects (CHDs) as part of Holt-Oram syndrome (HOS)...
  8. Postma A, van de Meerakker J, Mathijssen I, Barnett P, Christoffels V, Ilgun A, et al. A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fibrillation. Circ Res. 2008;102:1433-42 pubmed publisher
    ..Mutations in T-box transcription factor 5 (TBX5) underlie this syndrome...
  9. Fan C, Chen Q, Wang Q. Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram syndrome via association with SC35. J Biol Chem. 2009;284:25653-63 pubmed publisher
    b>TBX5 is a T-box transcriptional factor required for cardiogenesis and limb development. TBX5 mutations cause Holt-Oram syndrome characterized by congenital heart defects and upper limb deformations...
  10. Stirnimann C, Ptchelkine D, Grimm C, Müller C. Structural basis of TBX5-DNA recognition: the T-box domain in its DNA-bound and -unbound form. J Mol Biol. 2010;400:71-81 pubmed publisher
    b>TBX5, a member of the T-box transcription factor family, plays an important role in heart and limb development...
  11. Leduc N, Ahomadégbé C, Agossou M, Aline Fardin A, Mahjoubi L, Dufrenot Petitjean Roget L, et al. Incidence of Lung Adenocarcinoma Biomarker in a Caribbean and African Caribbean Population. J Thorac Oncol. 2016;11:769-773 pubmed publisher
    ..3-kinase catalytic subunit alpha gene (PIK3CA), ROS proto-oncogene 1, receptor tyrosine kinase gene (ROS), and MMNG HOS Transforming gene (MET)...
  12. Reddy K, Reddy P. Testicular and epididymal toxicity induced by benzo(a)pyrene, alcohol, and their combination in Wistar rats. Toxicol Res (Camb). 2016;5:420-433 pubmed publisher
    ..to BaP or alcohol significantly decreased daily sperm production, sperm density, percentages of motile, viable, HOS-tail swelled sperm, testicular 3?- and 17?-hydroxysteroid dehydrogenase activity levels, mRNA levels of ..
  13. Wystrychowski W, Patlolla B, Zhuge Y, Neofytou E, Robbins R, Beygui R. Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum. Stem Cell Res Ther. 2016;7:84 pubmed publisher
    ..was initiated with exogenous overexpression of seven transcription factors (ESRRG, GATA4, MEF2C, MESP1, MYOCD, TBX5, ZFPM2) previously applied successfully for fibroblast transdifferentiation toward cardiomyocytes...
  14. Magierowski M, Magierowska K, Hubalewska Mazgaj M, Surmiak M, Sliwowski Z, Wierdak M, et al. Cross-talk between hydrogen sulfide and carbon monoxide in the mechanism of experimental gastric ulcers healing, regulation of gastric blood flow and accompanying inflammation. Biochem Pharmacol. 2018;149:131-142 pubmed publisher
    ..CSE), cystathionine-β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MST), heme oxygenases (HOs), nuclear factor (erythroid-derived 2)-like 2 (Nrf-2), cyclooxygenase (COX)-2, inducible nitric oxide synthase (..
  15. Shen Y, Zhao S, Wang S, Pan X, Zhang Y, Xu J, et al. S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma. EBioMedicine. 2019;40:210-223 pubmed publisher
    ..RNA sequencing was used to compare gene expression patterns between S1PR3-knockdown and control MNNG-HOS cells. In addition, metabolic alternations in OS cells were monitored by XF96 metabolic flux analyzer...
  16. Nelli G, Pamanji S. Di-n-butyl phthalate prompts interruption of spermatogenesis, steroidogenesis, and fertility associated with increased testicular oxidative stress in adult male rats. Environ Sci Pollut Res Int. 2017;24:18563-18574 pubmed publisher
    ..seminal vesicle tissue somatic indices, epididymal sperm count, motility, viability, and hypoosmotic swelling (HOS) sperm were significantly decreased with increased sperm morphological abnormalities in DBP-treated adult male rats...
  17. Zhang W, Li Q, Song C, Lao L. Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells. Tumour Biol. 2015;36:2531-9 pubmed publisher
    ..As a result, HOS osteosarcoma cells exhibited higher Beclin-1 expression...
  18. Tickle C. How the embryo makes a limb: determination, polarity and identity. J Anat. 2015;227:418-30 pubmed publisher
    ..in the embryo become determined to form a limb and express the key transcription factors Tbx4 (leg/hindlimb) or Tbx5 (wing/forelimb)...
  19. Sai Siva Ram A, Pratap Reddy K, Girish B, Supriya C, Sreenivasula Reddy P. Arsenic aggravated reproductive toxicity in male rats exposed to lead during the perinatal period. Toxicol Res (Camb). 2018;7:1191-1204 pubmed publisher
    ..ventral prostate; (2) daily sperm production; (3) epididymal sperm density and (4) numbers of motile, viable, and HOS tail swelled sperm declined significantly in the rats exposed to either Pb or As...
  20. Sparić R, Mirković L, Ravilić U, Janjić T. Obstetric complications of placenta previa percreta. Vojnosanit Pregl. 2014;71:1163-6 pubmed
    ..rupture, cystostomy, fistula formation, ureteral stricture, intensive care unit admission, infection, and prolonged hos- pitalization, adult respiratory distress syndrome, renal failure, septicemia and even death...
  21. Sunami K, Furuta K, Tsuta K, Sasada S, Izumo T, Nakaoku T, et al. Multiplex Diagnosis of Oncogenic Fusion and MET Exon Skipping by Molecular Counting Using Formalin-Fixed Paraffin Embedded Lung Adenocarcinoma Tissues. J Thorac Oncol. 2016;11:203-12 pubmed publisher
    ..ROS1), B-Raf proto-oncogene, serine/threonine kinase gene (BRAF), and neuregulin 1 gene (NRG1) and intronic MMNG HOS Transforming gene (MET) mutations are druggable oncogene alterations in lung adenocarcinoma that cause expression ..
  22. Wilks A, Heinzl G. Heme oxygenation and the widening paradigm of heme degradation. Arch Biochem Biophys. 2014;544:87-95 pubmed publisher
    ..However, whereas the P450s promote cleavage of the ferric hydroperoxide OO bond to the oxoferryl species the HOs stabilize the ferric hydroperoxide promoting hydroxylation at the heme edge...
  23. Reddy K, Narayana Rao M, Murthy J, Reddy P. Lead aggravates the diabetic-induced reproductive toxicity in male Wistar rats. Toxicol Res (Camb). 2016;5:1465-1476 pubmed publisher
    ..Daily sperm production, epididymal sperm count, motile, viable and HOS-tail swelled sperms, serum testosterone levels and testicular 3?- and 17?-hydroxysteroid dehydrogenase activity ..
  24. Singh N, Bhatla S. Nitric oxide and iron modulate heme oxygenase activity as a long distance signaling response to salt stress in sunflower seedling cotyledons. Nitric Oxide. 2016;53:54-64 pubmed publisher
    ..Its catabolism is carried out by heme oxygenase (HOs; EC 1.14.99.3) which uses heme both as a prosthetic group and as a substrate...
  25. Kriz V, Korinek V. Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells. Genes (Basel). 2018;9: pubmed publisher
    ..kinase (YES1) leads to the formation of a transcriptional complex that includes YAP1, ?-catenin and T-box 5 (TBX5) DNA-binding protein...
  26. Gu J, Lu Y, Li F, Qiao L, Wang Q, Li N, et al. Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation. Cell Death Dis. 2014;5:e1469 pubmed publisher
    ..of this 150-bp enhancer and identification of its multiple binding factors, including AP1, MEF2, NFAT, Runx1 and TBX5. Using this enhancer as bait, we performed yeast one-hybrid assay and identified multiple candidate Col10a1-..
  27. Rommel C, Rösner S, Lother A, Barg M, Schwaderer M, Gilsbach R, et al. The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia. Circ Res. 2018;: pubmed publisher
    ..formation (Ryr2, Jph2, Gja5), potassium channels (Kcnh2, Kcnk3) as well as genes implicated in AF (Tbx5) were part of this ETV1-driven gene regulatory network...
  28. Park E, Takimoto K. A long-lasting cardiomyogenic gene expression by PEI-based transfection induces endogenous cardiac mRNAs in human adipose-derived stem cells. Biochem Biophys Res Commun. 2016;479:12-6 pubmed publisher
    ..to test whether a single introduction of cDNAs for the three cardiomyogenic reprogramming genes (GATA4, MEF2C, and TBX5) might be sufficient to induce transdifferentiation of hADSCs towards the cardiomyogenic lineage...
  29. Massoud S, Louka F, Ducharme G, Fischer R, Mautner F, Vančo J, et al. Copper(II) complexes based on tripodal pyrazolyl amines: Synthesis, structure, magnetic properties and anticancer activity. J Inorg Biochem. 2018;180:39-46 pubmed publisher
    ..was investigated against four human cancer cell lines: A2780 (ovarian), A2780R (cisplatin-resistant variant), HOS (aggressive bone tumors), CaCo2 (epithelial colorectal adenocarcinoma) and on healthy human hepatocytes...
  30. Wang Y, Shi S, Liu H, Meng L. Hypoxia Enhances Direct Reprogramming of Mouse Fibroblasts to Cardiomyocyte-Like Cells. Cell Reprogram. 2016;18:1-7 pubmed publisher
    ..cardiac-related genes and proteins increased at 4 weeks after transfer of three transcription factors (Gata4/Mef2c/Tbx5 [GMT]). However, beating cardiomyocyte cells were not detected...
  31. Weber A, Kuhns B, Cvetanovich G, Grzybowski J, Salata M, Nho S. Amateur and Recreational Athletes Return to Sport at a High Rate Following Hip Arthroscopy for Femoroacetabular Impingement. Arthroscopy. 2017;33:748-755 pubmed publisher
    ..questionnaire, modified Harris Hip Score (MHHS), and Hip Outcome Scores with Activities of Daily Living (HOS-ADL) and Sports-Specific (HOS-SS) subscales were collected...
  32. Cai X, Liu Y, Yang W, Xia Y, Yang C, Yang S, et al. Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma. J Orthop Res. 2016;34:932-41 pubmed publisher
    ..of tubular network structures and caused breakage of stress fibers in osteosarcoma cell lines U2OS and MNNG/HOS. Furthermore, MALAT1 knockdown delayed tumor growth in an osteosarcoma xenograft model...
  33. Zhang S, Qian J, Zhang Z, Shen L, Wu X, Hu X. Age- and Parkinson's disease-related evaluation of gait by General Tau Theory. Exp Brain Res. 2016;234:2829-40 pubmed publisher
    ..Fifteen patients with PD, 11 healthy old adults (HOs), and 15 healthy young adults (HYs) were recruited...
  34. Wang P, Qin W, Wang P, Huang Y, Liu Y, Zhang R, et al. Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase Genetic Susceptibility to Atrial Fibrillation. Sci Rep. 2018;8:3297 pubmed publisher
    ..In 2014, two new meta-GWAS identified 5 AF loci, including the NEURL locus, GJA1 locus, CAND2 locus, and TBX5 locus in the European ancestry populations and the NEURL locus and CUX2 locus in a Japanese population...
  35. Degen R, Nawabi D, Fields K, Wentzel C, Kelly B, Coleman S. Simultaneous Versus Staged Bilateral Hip Arthroscopy in the Treatment of Femoroacetabular Impingement. Arthroscopy. 2016;32:1300-7 pubmed publisher
    ..outcome scores, including the Modified Harris Hip Score (mHHS), the Hip Outcome Score-Activity of Daily Living (HOS-ADL), and the Hip Outcome Score-Sport-Specific Subscale (HOS-SSS) were obtained preoperatively at 6 months and 1 ..
  36. Wang F, Liu D, Zhang R, Yu L, Zhao J, Yang X, et al. A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population. Cell Discov. 2017;3:17026 pubmed publisher
    b>TBX5 is a vital transcription factor involved in cardiac development in a dosage-dependent manner...
  37. Hatcher C, Kim M, Mah C, Goldstein M, Wong B, Mikawa T, et al. TBX5 transcription factor regulates cell proliferation during cardiogenesis. Dev Biol. 2001;230:177-88 pubmed
    Mutations in human TBX5, a member of the T-box transcription factor gene family, cause congenital cardiac septation defects and isomerism in autosomal dominant Holt-Oram syndrome...
  38. Chandrasekaran S, Vemula S, Lindner D, Lodhia P, Suárez Ahedo C, Domb B. Preoperative Delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) for Patients Undergoing Hip Arthroscopy: Indices Are Predictive of Magnitude of Improvement in Two-Year Patient-Reported Outcomes. J Bone Joint Surg Am. 2015;97:1305-15 pubmed publisher
    ..Harris hip score (mHHS), the Nonarthritic Hip Score (NAHS), the Hip Outcome Score Activities of Daily Living (HOS-ADL), and the Hip Outcome Score Sport-Specific Subscale (HOS-SSS) as well as a visual analog scale (VAS) for pain ..
  39. Janne P, Shaw A, Camidge D, Giaccone G, Shreeve S, Tang Y, et al. Combined Pan-HER and ALK/ROS1/MET Inhibition with Dacomitinib and Crizotinib in Advanced Non-Small Cell Lung Cancer: Results of a Phase I Study. J Thorac Oncol. 2016;11:737-747 pubmed publisher
    ..Only one sample showed MMNG HOS Transforming gene (MET) amplification (the patient had progressive disease), whereas 59% (13 of 22) and 47% (14 of ..
  40. Mohamed T, Stone N, Berry E, Radzinsky E, Huang Y, Pratt K, et al. Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming. Circulation. 2017;135:978-995 pubmed publisher
    ..A combination of 3 cardiac transcription factors, Gata4, Mef2c, and Tbx5 (GMT), can convert fibroblasts into induced cardiomyocyte-like cells, albeit with low efficiency in vitro...
  41. Ma H, Wang L, Liu J, Qian L. Direct Cardiac Reprogramming as a Novel Therapeutic Strategy for Treatment of Myocardial Infarction. Methods Mol Biol. 2017;1521:69-88 pubmed
    ..that in a murine model of acute myocardial infarction, delivery of three transcription factors, Gata4, Mef2c, and Tbx5 converted endogenous cardiac fibroblasts into functional iCMs...
  42. Singh V, Mathison M, Patel V, Sanagasetti D, Gibson B, Yang J, et al. MiR-590 Promotes Transdifferentiation of Porcine and Human Fibroblasts Toward a Cardiomyocyte-Like Fate by Directly Repressing Specificity Protein 1. J Am Heart Assoc. 2016;5: pubmed
    ..Lentivirus vectors expressing Gata4, Mef2c, and Tbx5 (GMT); Hand2 (H), Myocardin (My), or microRNA (miR)-590 were administered to rat, porcine, and human cardiac ..
  43. Ma Y, Xu X, Luo M. CXCR6 promotes tumor cell proliferation and metastasis in osteosarcoma through the Akt pathway. Cell Immunol. 2017;311:80-85 pubmed publisher
    ..study aimed to explore the expression levels and function of CXCR6 in OS tissues and osteosarcoma cell lines MG-63, HOS and U2OS...
  44. Husmann K, Ducommun P, Sabile A, Pedersen E, Born W, Fuchs B. Signal transduction and downregulation of C-MET in HGF stimulated low and highly metastatic human osteosarcoma cells. Biochem Biophys Res Commun. 2015;464:1222-1227 pubmed publisher
    ..its ligand hepatocyte growth factor (HGF) and the fusion oncogene product TPR-MET, first identified in human MNNG-HOS OS cells, have been described as cancer-causing factors in human cancers...
  45. Basson C, Huang T, Lin R, Bachinsky D, Weremowicz S, Vaglio A, et al. Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations. Proc Natl Acad Sci U S A. 1999;96:2919-24 pubmed
    To better understand the role of TBX5, a T-box containing transcription factor in forelimb and heart development, we have studied the clinical features of Holt-Oram syndrome caused by 10 different TBX5 mutations...
  46. Adachi N, Robinson M, Goolsbee A, Shubin N. Regulatory evolution of Tbx5 and the origin of paired appendages. Proc Natl Acad Sci U S A. 2016;113:10115-20 pubmed publisher
    ..To address this problem, we focused on T-box transcription factor 5 (Tbx5), a gene indispensable for pectoral appendage initiation and development...
  47. Yu Y, Wang Y, Ding W, Zhou J, Shi B. Preparation of highly-oxidized starch using hydrogen peroxide and its application as a novel ligand for zirconium tanning of leather. Carbohydr Polym. 2017;174:823-829 pubmed publisher
    A series of highly-oxidized starch (HOS) were prepared using H2O2 and a copper-iron catalyst as a desired ligand for zirconium tanning of leather...
  48. Irvin J, Ropelewski A, Perozich J. In silico analysis of heme oxygenase structural homologues identifies group-specific conservations. FEBS Open Bio. 2017;7:1480-1498 pubmed publisher
    ..Several other enzymes have homologous tertiary structures to HOs, while sharing little sequence homology...
  49. Nishimoto S, Wilde S, Wood S, Logan M. RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation. Cell Rep. 2015;12:879-91 pubmed publisher
    ..and that RA and β-catenin/TCF/LEF signaling act cooperatively with Hox gene inputs to directly regulate Tbx5 expression...
  50. Cvetanovich G, Levy D, Weber A, Kuhns B, Mather R, Salata M, et al. Do Patients With Borderline Dysplasia Have Inferior Outcomes After Hip Arthroscopic Surgery for Femoroacetabular Impingement Compared With Patients With Normal Acetabular Coverage?. Am J Sports Med. 2017;45:2116-2124 pubmed publisher
    ..The primary outcome measure was the Hip Outcome Score-Activities of Daily Living (HOS-ADL) at a minimum of 2 years postoperatively...
  51. Zhou H, Morales M, Hashimoto H, Dickson M, Song K, Ye W, et al. ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression. Genes Dev. 2017;31:1770-1783 pubmed publisher
    ..AKT1 in the presence of four cardiogenic transcription factors, GATA4, HAND2, MEF2C, and TBX5 (AGHMT), efficiently induces the cardiac gene program in mouse embryonic fibroblasts but not adult fibroblasts...
  52. Kokkinopoulos I, Ishida H, Saba R, Ruchaya P, Cabrera C, Struebig M, et al. Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo. PLoS ONE. 2015;10:e0140831 pubmed publisher
    ..Progressively, the nascent mesodermal gene Mesp1 terminated, and Nkx2-5+/Tbx5+ population rapidly replaced the Tbx5low+ population as the expression of the cardiac genes Tbx5 and Nkx2-5 ..
  53. Krych A, Sousa P, King A, Engasser W, Levy B. Intra-articular Diagnostic Injection Exhibits Poor Predictive Value for Outcome After Hip Arthroscopy. Arthroscopy. 2016;32:1592-600 pubmed publisher
    ..Outcomes were assessed with Modified Harris Hip Score and Hip Outcome Score (HOS). Univariate and multivariate models were performed to assess whether percent pain relief correlated with outcome...
  54. Tang C, Deng Y, Duan H, Zhang Y, Li Y, Qiu D, et al. The effect of maternal exposure to di-(2-ethylhexyl)-phthalate on fetal cardiac development in mice. J Appl Toxicol. 2018;38:834-842 pubmed publisher
    ..5/Gata4/Tbx5/Mef2c/Chf1 mRNA and protein expression, respectively...
  55. Wu Z, Chen S, Li Y, Li H, Chen J. Effect of centre-edge angle on clinical and quality of life outcomes after arthroscopic acetabular labral debridement. Int Orthop. 2016;40:1427-32 pubmed publisher
    ..Clinical outcomes were evaluated by modified Harris Hip Score (mHHS), Hip Outcome Score (HOS) for activities of daily living (ADL) and sports and Short Form 12 (SF-12)...
  56. Aung T, Roberto E, Wase A. Absent Left Main Coronary Artery and Separate Ostia of Left Coronary System in a Patient with Holt-Oram Syndrome and Sinus Node Dysfunction. Am J Case Rep. 2016;17:93-6 pubmed
    Holt-Oram syndrome (HOS) is a rare but significant syndrome consisting of structural heart defects, conduction abnormalities, and upper extremity anomalies...
  57. Palazzolo G, Quattrocelli M, Toelen J, Dominici R, Anastasia L, Tettamenti G, et al. Cardiac Niche Influences the Direct Reprogramming of Canine Fibroblasts into Cardiomyocyte-Like Cells. Stem Cells Int. 2016;2016:4969430 pubmed publisher
    ..We used a mix of transcription factors (GATA4, HAND2, TBX5, and MEF2C), known to be able to differentiate mouse and human somatic cells into ciCLMs...
  58. Gümbel D, Gelbrich N, Weiss M, Napp M, Daeschlein G, Sckell A, et al. New Treatment Options for Osteosarcoma - Inactivation of Osteosarcoma Cells by Cold Atmospheric Plasma. Anticancer Res. 2016;36:5915-5922 pubmed
    ..Human osteosarcoma cells (U2-OS and MNNG/HOS) were treated with cold atmospheric plasma and seeded in culture plates...
  59. Menge T, Briggs K, Dornan G, McNamara S, Philippon M. Survivorship and Outcomes 10 Years Following Hip Arthroscopy for Femoroacetabular Impingement: Labral Debridement Compared with Labral Repair. J Bone Joint Surg Am. 2017;99:997-1004 pubmed publisher
    ..The primary patient-reported outcome measure was the Hip Outcome Score (HOS) Activities of Daily Living (ADL) subscale...
  60. Kihara T, Kashitani K, Miyake J. In silico characterization of cell-cell interactions using a cellular automata model of cell culture. BMC Res Notes. 2017;10:283 pubmed publisher
    ..We used four types of cells; HeLa cells, human osteosarcoma (HOS) cells, rat mesenchymal stem cells (MSCs), and rat smooth muscle A7r5 cells...
  61. Nakagawa K, Anzai K. Stratum corneum lipid structure investigated by EPR spin-probe method: application of terpenes. Lipids. 2010;45:1081-7 pubmed publisher
    ..SC from the back of hairless mouse (HOS:HR-1) was stripped consecutively from one to three or four times using a glass plate coated with a cyanoacrylate ..
  62. Li Q, Guo Z, Chang Y, Yu X, Li C, Li H. Gata4, Tbx5 and Baf60c induce differentiation of adipose tissue-derived mesenchymal stem cells into beating cardiomyocytes. Int J Biochem Cell Biol. 2015;66:30-6 pubmed publisher
    ..In this study we have shown that the combination of Gata4, Tbx5 and Baf60c is sufficient for inducing ADMSCs to form cardiomyocytes...
  63. Morine M, Kohmoto T, Masuda K, Inagaki H, Watanabe M, Naruto T, et al. A unique TBX5 microdeletion with microinsertion detected in patient with Holt-Oram syndrome. Am J Med Genet A. 2015;167A:3192-6 pubmed publisher
    ..condition characterized by upper limb and congenital heart defects and caused by numerous germline mutations of TBX5 producing preterminal stop codons...
  64. Liu S, Gou L, Li A, Lou N, Gao H, Su J, et al. The Unique Characteristics of MET Exon 14 Mutation in Chinese Patients with NSCLC. J Thorac Oncol. 2016;11:1503-10 pubmed publisher
    ..Since the discovery of the MNNG HOS Transforming gene (MET) exon 14 mutation, it has been found to have the best potential to become one precise ..
  65. Hong K, Jin H, Lim J, Kim S, Go M, Oh B. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. J Hum Genet. 2010;55:336-41 pubmed publisher
  66. Sinner M, Tucker N, Lunetta K, Ozaki K, Smith J, Trompet S, et al. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation. 2014;130:1225-35 pubmed publisher
    ..13-1.23; P=6.5×10(-16)), GJA1 (rs13216675; RR=1.10; 95% CI, 1.06-1.14; P=2.2×10(-8)), TBX5 (rs10507248; RR=1.12; 95% CI, 1.08-1.16; P=5.7×10(-11)), and CAND2 (rs4642101; RR=1.10; 95% CI, 1.06-1.14; P=9...
  67. Wu G, Deng X, Song J, Chen F. Enhanced biological properties of biomimetic apatite fabricated polycaprolactone/chitosan nanofibrous bio-composite for tendon and ligament regeneration. J Photochem Photobiol B. 2018;178:27-32 pubmed publisher
    ..responses and biocompatibility of HAp-PCL/CS nanofibrous scaffolds were investigated with human osteoblast (HOS) cells for tendon regeneration and examined the primary osteoblast mechanism by in vitro method...
  68. Cross S, Ching Y, Li Q, Armstrong Buisseret L, Spranger S, Lyonnet S, et al. The mutation spectrum in Holt-Oram syndrome. J Med Genet. 2000;37:785-7 pubmed
  69. Smith J, Magnani J, Palmer C, Meng Y, Soliman E, Musani S, et al. Genome-wide association studies of the PR interval in African Americans. PLoS Genet. 2011;7:e1001304 pubmed publisher
    ..cohorts identified genome-wide significant associations with SNPs in SCN10A (rs6798015), MEIS1 (rs10865355), and TBX5 (rs7312625) that were highly correlated with SNPs identified in European and Asian GWA studies...
  70. Granados Riveron J, Pope M, Bu Lock F, Thornborough C, Eason J, Setchfield K, et al. Combined mutation screening of NKX2-5, GATA4, and TBX5 in congenital heart disease: multiple heterozygosity and novel mutations. Congenit Heart Dis. 2012;7:151-9 pubmed publisher
    ..Mutations of TBX5 cause Holt-Oram syndrome, which includes CHD as a clinical feature...
  71. Patel C, Silcock L, McMullan D, Brueton L, Cox H. TBX5 intragenic duplication: a family with an atypical Holt-Oram syndrome phenotype. Eur J Hum Genet. 2012;20:863-9 pubmed publisher
    Holt-Oram syndrome (HOS) is a rare autosomal dominant heart-hand syndrome due to mutations in the TBX5 transcription factor...
  72. Jhang W, Lee B, Kim G, Lee J, Yoo H. Clinical and molecular characterisation of Holt-Oram syndrome focusing on cardiac manifestations. Cardiol Young. 2015;25:1093-8 pubmed publisher
    Holt-Oram syndrome is characterised by CHD and limb anomalies. Mutations in TBX5 gene, encoding the T-box transcription factor, are responsible for the development of Holt-Oram syndrome, but such mutations are variably detected in 30-75% ..
  73. Zhang K, Xiang M, Zhou L, Liu J, Curry N, Heine Suñer D, et al. Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016;25:1140-51 pubmed publisher
    ..Our previous studies have demonstrated a genetic interaction between Tbx5 and Osr1 in the second heart field (SHF) for atrial septation...
  74. Hata Y, Kinoshita K, Mizumaki K, Yamaguchi Y, Hirono K, Ichida F, et al. Postmortem genetic analysis of sudden unexplained death syndrome under 50 years of age: A next-generation sequencing study. Heart Rhythm. 2016;13:1544-51 pubmed publisher
    ..Three cases with RYR2 or TBX5 variants showed possible pathogenic fibrosis of the cardiac conduction system...
  75. Hsia L, Ashley N, Ouaret D, Wang L, Wilding J, Bodmer W. Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers. Proc Natl Acad Sci U S A. 2016;113:E2162-71 pubmed publisher
    ..significantly differentially expressed in these two cell types: NKX2-3 and LRRC17 in myofibroblasts and SHOX2 and TBX5 in skin fibroblasts...
  76. Hickman J, Guo F, Camden M, Dunn N, Hanowski R. An observational study of the safety benefits of electronic logging devices using carrier-collected data. Traffic Inj Prev. 2017;18:312-317 pubmed publisher
    ..One way to limit fatigued driving is through prescriptive hours-of-service (HOS) regulations...
  77. Su W, Zhu P, Wang R, Wu Q, Wang M, Zhang X, et al. Congenital heart diseases and their association with the variant distribution features on susceptibility genes. Clin Genet. 2017;91:349-354 pubmed publisher
    ..Several susceptible genes, such as NKX2-5, GATA4 and TBX5, have been reported as closely related to heart and vessel development...
  78. Morris T, Picken A, Sharp D, Slater N, Hewitt C, Coopman K. The effect of Me2SO overexposure during cryopreservation on HOS TE85 and hMSC viability, growth and quality. Cryobiology. 2016;73:367-375 pubmed publisher
    ..We also saw a similar loss of membrane integrity and attachment efficiency after exposing osteoblast (HOS TE85) cells to Me2SO before, and after, cryopreservation...
  79. Caparica R, Yen C, Coudry R, Ou S, Varella Garcia M, Camidge D, et al. Responses to Crizotinib Can Occur in High-Level MET-Amplified Non-Small Cell Lung Cancer Independent of MET Exon 14 Alterations. J Thorac Oncol. 2017;12:141-144 pubmed publisher
    ..to MET inhibition has recently been described in NSCLC through two mechanisms: high-level amplification of the MNNG HOS Transforming gene (MET) (usually expressed relative to the chromosome 7 centromere [CEP7] when using fluorescence ..
  80. Chen H, Zhang X, Hou H, Wang J, Yang Q, Wang X, et al. Identification of a novel and functional mutation in the TBX5 gene in a patient by screening from 354 patients with isolated ventricular septal defect. Eur J Med Genet. 2017;60:385-390 pubmed publisher
    ..A number of genetic studies have linked TBX5 mutations to cardiac abnormalities...
  81. Hertig V, Matos Nieves A, Garg V, Villeneuve L, Mamarbachi M, Caland L, et al. Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis. J Cell Physiol. 2018;233:3218-3229 pubmed publisher
    ..mice, nestin staining was detected in atrial and ventricular cardiomyocytes and a subpopulation co-expressed Tbx5. At later stages of development, nestin immunoreactivity in cardiomyocytes gradually diminished and was absent in ..
  82. Horie M, Miyashita N, Mikami Y, Noguchi S, Yamauchi Y, Suzukawa M, et al. TBX4 is involved in the super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00193.2017 pubmed publisher
    ..factors important for lung mesenchyme development, including the T-box transcription factors TBX2, TBX4, and TBX5, were enriched in this lung-specific signature and were associated with super-enhancers...
  83. Wang X, Xu W, Wang S, Yu F, Feng J, Wang X, et al. Transdifferentiation of human MNNG/HOS osteosarcoma cells into vascular endothelial cells in vitro and in vivo. Oncol Rep. 2017;38:3153-3159 pubmed publisher
    ..However, whether human osteosarcoma MNNG/HOS cells can transdifferentiate into other types of cells has seldom been reported...
  84. Song Y, Li J. Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Biochem Biophys Res Commun. 2018;495:2369-2375 pubmed publisher
    ..suppressed the proliferation activity, induced cell cycle arrest in G0/G1 phase, and promoted apoptosis in HOS and MG-63 cells...
  85. Hofstetter G, Concin N, Marth C, Rinne T, Erdel M, Janecke A. Genetic analyses in a variant of Mayer-Rokitansky-Kuster-Hauser syndrome (MURCS association). Wien Klin Wochenschr. 2008;120:435-9 pubmed publisher
    ..1 as well as the TBX5/TBX3 region at 12q24.1...
  86. Yu J, Ma X, Cheung K, Li X, Tian L, Wang S, et al. Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer. Oncogene. 2010;29:6464-74 pubmed publisher
    T-box transcription factor 5 (TBX5) is a member of a phylogenetically conserved family of genes involved in the regulation of developmental processes. The function of TBX5 in cancer development is largely unclear...
  87. Shan J, Pang S, Qiao Y, Ma L, Wang H, Xing Q, et al. Functional analysis of the novel sequence variants within TBX5 gene promoter in patients with ventricular septal defects. Transl Res. 2012;160:237-8 pubmed publisher
  88. Rosenbluh J, Nijhawan D, Cox A, Li X, Neal J, Schafer E, et al. ?-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell. 2012;151:1457-73 pubmed publisher
    ..Specifically, we found that YAP1 and the transcription factor TBX5 form a complex with ?-catenin...
  89. Wang F, Yang X, Zhao J, Yu L, Zhang P, Duan W, et al. miR-10a and miR-10b target the 3'-untranslated region of TBX5 to repress its expression. Pediatr Cardiol. 2014;35:1072-9 pubmed publisher
    As a well-known transcription factor, TBX5 is involved in embryonic cardiac development. Although TBX5 functions in a dose-dependent manner, the posttranscriptional regulation of human TBX5 is poorly understood...
  90. Al Qattan M, Abou Al Shaar H. Molecular basis of the clinical features of Holt-Oram syndrome resulting from missense and extended protein mutations of the TBX5 gene as well as TBX5 intragenic duplications. Gene. 2015;560:129-36 pubmed publisher
    ..basis of the clinical features of Holt-Oram syndrome resulting from missense and extended protein mutations of the TBX5 gene as well as TBX5 intragenic duplications...
  91. Jeong H, Jung E, Sim Y, Kim S, Jang J, Hong K, et al. Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. Biochim Biophys Acta. 2015;1849:709-21 pubmed publisher
    ..We report that an Fbxo25-mediated SCF ubiquitination pathway regulates the protein levels and activities of Tbx5 and Nkx2-5 based on our studies using MG132, proteasome inhibitor, and the temperature sensitive ubiquitin system ..
  92. Becker J, May A, Gerges C, Anders M, Schmidt C, Veits L, et al. The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk. Cancer Med. 2016;5:888-91 pubmed publisher
    ..In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects ..