TBX3

Summary

Gene Symbol: TBX3
Description: T-box 3
Alias: TBX3-ISO, UMS, XHL, T-box transcription factor TBX3, T-box protein 3, bladder cancer related protein XHL
Species: human
Products:     TBX3

Top Publications

  1. Meneghini V, Odent S, Platonova N, Egeo A, Merlo G. Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects. Eur J Med Genet. 2006;49:151-8 pubmed
    ..Sequence analysis of TBX3 shows a new heterozygous mutation that causes a frame-shift (Nt...
  2. Bamshad M, Lin R, Law D, Watkins W, Krakowiak P, Moore M, et al. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nat Genet. 1997;16:311-5 pubmed
    ..We demonstrate that mutations in human TBX3, a member of the T-box gene family, cause ulnar-mammary syndrome in two families...
  3. Carlson H, Ota S, Song Y, Chen Y, Hurlin P. Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation. Oncogene. 2002;21:3827-35 pubmed
    b>Tbx3 is a member of the T-box family of transcription factors...
  4. Fan W, Huang X, Chen C, Gray J, Huang T. TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines. Cancer Res. 2004;64:5132-9 pubmed
    b>TBX3 is a transcription factor of the T-box gene family...
  5. Yarosh W, Barrientos T, Esmailpour T, Lin L, Carpenter P, Osann K, et al. TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases. Cancer Res. 2008;68:693-9 pubmed publisher
    b>TBX3 is a transcription factor of the T-box gene family. Mutations in the TBX3 gene can cause hypoplastic or absent mammary glands. Previous studies have shown that TBX3 might be associated with breast cancer...
  6. Rodriguez M, Aladowicz E, Lanfrancone L, Goding C. Tbx3 represses E-cadherin expression and enhances melanoma invasiveness. Cancer Res. 2008;68:7872-81 pubmed publisher
    The T-box transcription factors Tbx2 and Tbx3 are overexpressed in many cancers and in melanoma promote proliferation by actively suppressing senescence. Whether they also contribute to tumor progression via other mechanisms is not known...
  7. Boyd S, Mijatov B, Pupo G, Tran S, Gowrishankar K, Shaw H, et al. Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion. J Invest Dermatol. 2013;133:1269-77 pubmed publisher
    ..Here we identify a link between oncogenic B-RAF, the transcriptional repressor Tbx3, and E-cadherin...
  8. Bamshad M, Le T, Watkins W, Dixon M, Kramer B, Roeder A, et al. The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndrome. Am J Hum Genet. 1999;64:1550-62 pubmed
    ..Mutations that disrupt the DNA-binding domain of the T-box gene, TBX3, have been demonstrated to cause UMS...
  9. He M, Wen L, Campbell C, Wu J, Rao Y. Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. Proc Natl Acad Sci U S A. 1999;96:10212-7 pubmed
    ..We report here that ET is an ortholog of the human Tbx3 and that ET is a repressor of basal and activated transcription...

More Information

Publications106 found, 100 shown here

  1. Brummelkamp T, Kortlever R, Lingbeek M, Trettel F, MacDonald M, Van Lohuizen M, et al. TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J Biol Chem. 2002;277:6567-72 pubmed
    ..These data suggest that the hypoproliferative features of this genetic disorder may be caused, at least in part, by deregulated expression of p14(ARF). ..
  2. Coll M, Seidman J, Müller C. Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome. Structure. 2002;10:343-56 pubmed
    ..Mutations in human T-box genes TBX3, TBX5, and TBX1 cause severe genetic disorders known as Ulnar-Mammary syndrome (UMS), Holt-Oram syndrome (HOS), and ..
  3. Lee H, Cho H, Kim H, Bae Y, Baik H, Jung J. Tbx3, a transcriptional factor, involves in proliferation and osteogenic differentiation of human adipose stromal cells. Mol Cell Biochem. 2007;296:129-36 pubmed
    b>Tbx3 is a transcription factor, the mutation of which causes ulnar mammary syndrome (UMS) characterized by abnormality and hypoplasia of the mammary gland, teeth, limbs, hair and genitalia...
  4. Mowla S, Pinnock R, Leaner V, Goding C, Prince S. PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration. Biochem J. 2011;433:145-53 pubmed publisher
    The T-box transcription factor TBX3 provides an important link between embryonic development and cancer...
  5. Fillmore C, Gupta P, Rudnick J, Caballero S, Keller P, Lander E, et al. Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010;107:21737-42 pubmed publisher
    ..epithelial biology, estrogen signaling expands the pool of functional breast CSCs through a paracrine FGF/FGFR/Tbx3 signaling pathway...
  6. Smith J, Mowla S, Prince S. Basal transcription of the human TBX3 gene, a key developmental regulator which is overexpressed in several cancers, requires functional NF-Y and Sp1 sites. Gene. 2011;486:41-6 pubmed publisher
    b>TBX3 is a member of the T-box family of genes that encode developmentally important transcription factors...
  7. Humtsoe J, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, et al. Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells. Exp Cell Res. 2012;318:379-90 pubmed publisher
    ..Importantly, the Tbx3 gene, a member of the T-box transcription factor, was strongly upregulated in SCC cells displaying an EMT-like ..
  8. Carlson H, Ota S, Campbell C, Hurlin P. A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome. Hum Mol Genet. 2001;10:2403-13 pubmed
    Mutations in Tbx3 are responsible for ulnar-mammary syndrome (UMS), an autosomal dominant disorder affecting limb, tooth, hair, apocrine gland and genital development...
  9. Lingbeek M, Jacobs J, Van Lohuizen M. The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. J Biol Chem. 2002;277:26120-7 pubmed
    ..are known to date, among which are the T-box genes TBX2, which resides on an amplicon in primary breast tumors, and TBX3, which is mutated in the human developmental disorder Ulnar-Mammary syndrome...
  10. Lomnytska M, Dubrovska A, Hellman U, Volodko N, Souchelnytskyi S. Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients. Int J Cancer. 2006;118:412-21 pubmed
    ..Truncated forms of cytosolic serine hydroxymethyl transferase (cSHMT), T-box transcription factor 3 (Tbx3) and utrophin were aberrantly expressed in samples from cancer patients as compared to samples from noncancerous ..
  11. Mommersteeg M, Hoogaars W, Prall O, de Gier de Vries C, Wiese C, Clout D, et al. Molecular pathway for the localized formation of the sinoatrial node. Circ Res. 2007;100:354-62 pubmed
    ..of the heart tube matures, Nkx2-5 suppresses pacemaker channel gene Hcn4 and T-box transcription factor gene Tbx3, thereby enforcing a progressive confinement of their expression to the forming Nkx2-5-negative sinoatrial node and ..
  12. Pfeufer A, van Noord C, Marciante K, Arking D, Larson M, Smith A, et al. Genome-wide association study of PR interval. Nat Genet. 2010;42:153-9 pubmed publisher
    ..of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes...
  13. Boogerd C, Wong L, van den Boogaard M, Bakker M, Tessadori F, Bakkers J, et al. Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43. Cell Mol Life Sci. 2011;68:3949-61 pubmed publisher
    b>Tbx3, a T-box transcription factor, regulates key steps in development of the heart and other organ systems. Here, we identify Sox4 as an interacting partner of Tbx3...
  14. Tobias I, Brooks C, Teichroeb J, Villagómez D, Hess D, Séguin C, et al. Small-Molecule Induction of Canine Embryonic Stem Cells Toward Naïve Pluripotency. Stem Cells Dev. 2016;25:1208-22 pubmed publisher
    ..propagated in 2iL exhibited significant induction of genes associated with the naïve pluripotent state (eg, REX1, TBX3) and downregulation of primed pluripotency markers (eg, OTX2, FGF5) (P?<?0.05)...
  15. Kim J, Nagappan A, Park H, Saralamma V, Hong G, Yumnam S, et al. Proteome profiling of lipopolysaccharide induced L6 rat skeletal muscle cells response to flavonoids from Scutellaria baicalensis Georgi. BMC Complement Altern Med. 2014;14:379 pubmed publisher
    ..and database searching, that's involved in inflammatory responses such vimentin, T-box transcription factor TBX3, annexin A1, annexin A2 and annexin A5...
  16. England J, Pang K, Parnall M, Haig M, Loughna S. Cardiac troponin T is necessary for normal development in the embryonic chick heart. J Anat. 2016;229:436-49 pubmed publisher
    ..PCR was performed to determine the expression of the shear stress responsive gene NOS3 and the conduction gene TBX3. Both genes were differentially expressed compared to controls...
  17. van de Nes J, Nelles J, Kreis S, Metz C, Hager T, Lohmann D, et al. Comparing the Prognostic Value of BAP1 Mutation Pattern, Chromosome 3 Status, and BAP1 Immunohistochemistry in Uveal Melanoma. Am J Surg Pathol. 2016;40:796-805 pubmed publisher
    ..dosage analysis of all BAP1 coding exons as well as methylation analysis of the promoter CpG island in a set of 66 UMs. The results were compared with the BAP1 protein expression as determined by immunohistochemistry and the tumor-..
  18. Spina E, de Leon J. Clinical applications of CYP genotyping in psychiatry. J Neural Transm (Vienna). 2015;122:5-28 pubmed publisher
    ..3) CYP2D6 PMs taking venlafaxine, aripiprazole, haloperidol, risperidone or zuclopenthixol; and (4) CYP2D6 UMs taking venlafaxine, aripiprazole, haloperidol, risperidone, zuclopenthixol or atomoxetine...
  19. Liang X, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann N, et al. Transcription factor ISL1 is essential for pacemaker development and function. J Clin Invest. 2015;125:3256-68 pubmed publisher
    ..several genes required for normal pacemaker function, including subunits of the L-type calcium channel, Ank2, and Tbx3. Other genes implicated in abnormal heart rhythm in humans were also direct ISL1 targets...
  20. Zacksenhaus E, Liu J, Jiang Z, Yao Y, Xia L, Shrestha M, et al. Transcription Factors in Breast Cancer-Lessons From Recent Genomic Analyses and Therapeutic Implications. Adv Protein Chem Struct Biol. 2017;107:223-273 pubmed publisher
    ..g., NOTCH1/2 for CSL/RBPJk) are induced. In contrast, constitutive (MYC, TBX3) and signal-induced (TP53, FOXA1) DB-TFs that do not mediate default repression are directly altered in breast ..
  21. Liu Q, MA L. Knockdown of thrombospondin 2 inhibits metastasis through modulation of PI3K signaling pathway in uveal melanoma cell line M23. Eur Rev Med Pharmacol Sci. 2018;22:6230-6238 pubmed publisher
    ..THBS2 was up-regulated in metastatic UMs. Relationship of THBS2 expression level with the clinicopathological factors demonstrated that the expression level ..
  22. Brinckmann M, Kaschina E, Altarche Xifró W, Curato C, Timm M, Grzesiak A, et al. Estrogen receptor alpha supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells. J Mol Cell Cardiol. 2009;47:66-75 pubmed publisher
    ..factors implicated in cardiogenic differentiation (GATA-4, Notch-2) and genes required for self-renewal (Tbx3, Akt), maintained a stable phenotype in vitro for more than 3 months...
  23. Zhao H, Han Z, Liu X, Gu J, Tang F, Wei G, et al. The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes. J Biol Chem. 2017;292:8507-8519 pubmed publisher
    ..Importantly, Chd4 repressed the transcription of T box protein 3 (Tbx3), a transcription factor with important functions in ESC fate determination...
  24. Botero A, Kapeller I, Cooper C, Clode P, Shlomai J, Thompson R. The kinetoplast DNA of the Australian trypanosome, Trypanosoma copemani, shares features with Trypanosoma cruzi and Trypanosoma lewisi. Int J Parasitol. 2018;48:691-700 pubmed publisher
    ..Minicircle Sequence is located at the replication origin of the minicircles, and is the binding site for the UMS binding protein, a protein involved in trypanosomatid survival and virulence...
  25. Costello I, Biondi C, Taylor J, Bikoff E, Robertson E. Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development. BMC Dev Biol. 2009;9:54 pubmed publisher
    ..We also observed an increase in non-canonical potency markers (Pramel7, Tbx3, Zscan4), germ cell markers (Aire, Tuba3a, Dnmt3l) as well as early endoderm markers (Dpp4, H19, Dcn)...
  26. Wiese C, Nikolova T, Zahanich I, Sulzbacher S, Fuchs J, Yamanaka S, et al. Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin. Int J Cardiol. 2011;147:95-111 pubmed publisher
    ..At advanced differentiation stages, sinus node-specific HCN4, Tbx2 and Tbx3 transcript levels were significantly up-regulated...
  27. Fujino N, Kubo H, Maciewicz R. Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype. Lab Invest. 2017;97:1047-1062 pubmed publisher
    ..of a unique profile of epithelial-to-mesenchymal transition transcription factors including SNAI2, HOXA5, TBX2 or TBX3. Finally, we observed that Axl was activated in hyperplasia of epithelial cells in idiopathic pulmonary fibrosis ..
  28. Xue C, Zhang J, Lv Z, Liu H, Huang C, Yang J, et al. Angiotensin II promotes differentiation of mouse c-kit-positive cardiac stem cells into pacemaker-like cells. Mol Med Rep. 2015;11:3249-58 pubmed publisher
    ..including hyperpolarization‑activated cyclic nucleotide‑gated (HCN)2, HCN4, T‑box (Tbx)2 and Tbx3, were significantly upregulated...
  29. Liu F, Lu M, Patel N, Schillinger K, Wang T, Patel V. GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and Function. Circ Cardiovasc Genet. 2015;8:284-93 pubmed publisher
    ..Finally, carboxyl zinc-finger deletion of Gata6 reduces cell-cycle exit of TBX3+ myocytes in the developing atrioventricular bundle during the period of atrioventricular node specification, which ..
  30. Segal J, Ward C. Novel peptides for deciphering structural and signalling functions of E-cadherin in mouse embryonic stem cells. Sci Rep. 2017;7:41827 pubmed publisher
    ..Alanine scanning mutation of Epep revealed residues critical for Tbx3, Klf4 and Esrrb transcript repression, cell-cell contact abrogation, cell survival in suspension, STAT3 ..
  31. Miao Z, Liu X, Xu H, Wang Z, Zhao T, Song Y, et al. Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion. Virchows Arch. 2016;469:505-513 pubmed
    The objective of the current study was to investigate the expression pattern of Tbx3 and its clinicopathological significance in patients with gastric cancer...
  32. Hamadeh I, Klinker K, Borgert S, Richards A, Li W, Mangal N, et al. Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections. Pharmacogenet Genomics. 2017;27:190-196 pubmed publisher
    ..Of 70 patients included (mean age 52.5±18 years), 39% were RMs or UMs. Compared with patients with the other phenotypes, RMs/UMs had a lower steady-state trough concentration (4.26±2...
  33. Chen D, Qiao Y, Meng H, Pang S, Huang W, Zhang H, et al. Genetic analysis of the TBX3 gene promoter in ventricular septal defects. Gene. 2013;512:185-8 pubmed publisher
    ..Genetic causes and underlying molecular mechanisms for CHD remain largely unknown. T-box transcription factor 3 (TBX3) plays a critical role in the developing heart in a dose-dependent manner...
  34. Kang J, Zuo Y, Guo Q, Wang H, Liu Q, Xia G, et al. Xylaria hypoxylon Lectin as Adjuvant Elicited Tfh Cell Responses. Scand J Immunol. 2015;82:436-42 pubmed publisher
    ..response of FMDV antigen (146S), C57BL/6 mice were immunized with 146S combined with Xylaria hypoxylon lectin (XHL). The oil formulation (146S/Oil) was served as control group...
  35. Husse B, Franz W. Generation of cardiac pacemaker cells by programming and differentiation. Biochim Biophys Acta. 2016;1863:1948-52 pubmed publisher
    ..Another key transcription factor is Tbx3 specifically expressed in the cardiac conduction system including the sinoatrial node and sufficient for the ..
  36. Lu X, Wang L, Lin X, Huang J, Charles Gu C, He M, et al. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. Hum Mol Genet. 2015;24:865-74 pubmed publisher
    ..MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIGN, ULK4, GUCY1A3, HFE, TBX3-TBX5, and TBX3) at a suggestive level of P = 1.81 × 10(-3) to 5.16 × 10(-8)...
  37. Baumann J, Affolter B. The paradoxical role of urinary macromolecules in the aggregation of calcium oxalate: a further plea to increase diuresis in stone metaphylaxis. Urolithiasis. 2016;44:311-7 pubmed publisher
    ..crystals (CaOx) which seems to occur in stone formation despite a protecting coat of urinary macromolecules (UMs)...
  38. Kriegel A, Baker M, Liu Y, Liu P, Cowley A, Liang M. Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes. Hypertension. 2015;66:793-9 pubmed publisher
    ..family, GOSR2 by miR-27a-3p, JAG1 by miR-21-5p, SH2B3 by miR-30a-5p, miR-98, miR-181a-5p, and the miR-125 family, TBX3 by the miR-92 family, ADRA1B by miR-22-3p, ADRA2A by miR-30a-5p and miR-30e-5p, ADRA2B by miR-30e-5p, ADRB1 by the ..
  39. Mouti M, Dee C, Coupland S, Hurlstone A. Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish. Oncotarget. 2016;7:39654-39670 pubmed publisher
    ..summary, our findings demonstrate a weak correlation between oncogenic GNAQQ209P mutation and sustained ERK1/2-MAPK activation, implying that ERK1/2 signalling is unlikely to be instrumental in the maintenance of GNAQQ209P-driven UMs.
  40. Tanteles G, Nicolaou N, Syrimis A, Metaxa R, Nicolaou M, Christophidou Anastasiadou V, et al. Novel TBX3 mutation in a family of Cypriot ancestry with ulnar-mammary syndrome. Clin Dysmorphol. 2017;26:61-65 pubmed publisher
    Ulnar-mammary syndrome (UMS) is an autosomal dominant disorder resulting from TBX3 haploinsufficiency...
  41. Schneider M, Scheffer K, Bund T, Boukhallouk F, Lambert C, Cotarelo C, et al. The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs. J Virol. 2013;87:4461-74 pubmed publisher
    ..and immunofluorescence analyses confirmed the L2-TBX2 interaction and revealed that L2 also interacts with TBX3, another member of the T-box family...
  42. Ben S, Cooper Dehoff R, Flaten H, Evero O, Ferrara T, Spritz R, et al. Multiplex SNaPshot-a new simple and efficient CYP2D6 and ADRB1 genotyping method. Hum Genomics. 2016;10:11 pubmed publisher
    ..8 %) extensive metabolizers (EMs), and 5 (4.2 %) ultra-rapid metabolizers (UMs). We genotyped two variants in the ?1-adrenoreceptor, rs1801253 (Gly389Arg) and rs1801252 (Ser49Gly)...
  43. Colasanto M, Eyal S, Mohassel P, Bamshad M, BONNEMANN C, Zelzer E, et al. Development of a subset of forelimb muscles and their attachment sites requires the ulnar-mammary syndrome gene Tbx3. Dis Model Mech. 2016;9:1257-1269 pubmed
    ..Mutations in the T-box transcription factor, TBX3, have previously been identified as the genetic cause of ulnar-mammary syndrome (UMS), characterized by distinctive ..
  44. Arendt L, St Laurent J, Wronski A, Caballero S, Lyle S, Naber S, et al. Human breast progenitor cell numbers are regulated by WNT and TBX3. PLoS ONE. 2014;9:e111442 pubmed publisher
    ..To examine the effects of WNT signaling and TBX3 expression on progenitor activity in the breast, primary human mammary epithelial cells (MEC) were isolated from ..
  45. Kader A, Li Y, Dong K, Irwin D, Zhao Q, He X, et al. Population Variation Reveals Independent Selection toward Small Body Size in Chinese Debao Pony. Genome Biol Evol. 2015;8:42-50 pubmed publisher
    ..More interestingly, we found a candidate gene TBX3, which had not been observed in previous studies on horse body size that displayed the highest differentiation and ..
  46. Kispert A. T-Box Genes in the Kidney and Urinary Tract. Curr Top Dev Biol. 2017;122:245-278 pubmed publisher
    ..and discuss the body of evidence that Tbx18 and other members of the T-box gene family, namely, Tbx1, Tbx2, Tbx3, and Tbx20, play additional roles in development and homeostasis of other components of the excretory system in ..
  47. Sheeba C, Logan M. The Roles of T-Box Genes in Vertebrate Limb Development. Curr Top Dev Biol. 2017;122:355-381 pubmed publisher
    ..All four members of Tbx2 subfamily (Tbx2, Tbx3, Tbx4, Tbx5) and three members of Tbx1 (Tbx1, Tbx15, Tbx18), Brachyury (T) and Eomes (Tbr2) are expressed in the ..
  48. Marouf C, Göhler S, Filho M, Hajji O, Hemminki K, Nadifi S, et al. Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population. BMC Cancer. 2016;16:165 pubmed publisher
    ..polymorphisms (SNPs) in 13 genes (APOBEC3A, APOBEC3B, ARID1B, ATR, MAP3K1, MLL2, MLL3, NCOR1, RUNX1, SF3B1, SMAD4, TBX3, TTN), which were located in the core promoter, 5'-and 3'UTR or which were nonsynonymous SNPs to assess their ..
  49. Qiao Y, Lipovsky C, HICKS S, Bhatnagar S, Li G, Khandekar A, et al. Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice. Circ Res. 2017;121:549-563 pubmed publisher
    ..of key transcriptional regulators of sinus node and atrial conduction, including Nkx2-5 (NK2 homeobox 5), Tbx3, and Tbx5 are dysregulated...
  50. Chen Z, Lu G, Ji T. [Expression of TBX3 mRNA and its role in the pathogenesis and metastasis of breast cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:87-9 pubmed
    To explore the role of TBX3 gene in the pathogenesis of breast cancer...
  51. Mori T, Sukeda A, Sekine S, Shibata S, Ryo E, Okano H, et al. SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas. Invest Ophthalmol Vis Sci. 2017;58:5445-5451 pubmed publisher
    ..SOX10 was expressed diffusely in all 11 UMs and in surrounding uveal or choroidal melanocytes, but not in the APCEs or nontumorous pigmented epithelia...
  52. McManus E, McCarthy S, Carson R, Sahm L. Impact of a Universal Medication Schedule on rationalising and understanding of medication; a randomised controlled trial. Res Social Adm Pharm. 2018;14:831-838 pubmed publisher
    ..To assess the impact of a Universal Medication Schedule (UMS) on the knowledge and consolidation of a prescription drug regimen compared to standard pharmacy labelling...
  53. Ang L, Tan A, Autio M, Goh S, Choo S, Lee K, et al. A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells. Cell Rep. 2018;22:2190-2205 pubmed publisher
    ..This efficiently generated 94.1% ± 7.35% TBX3+HNF4A+ human liver bud progenitors and 81.5% ± 3...
  54. Hong K, Lim J, Kim J, Tabara Y, Ueshima H, Miki T, et al. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. Hum Mol Genet. 2014;23:6659-67 pubmed publisher
    ..In addition, C allele of rs17026156 increases PR interval (beta ± SE, 2.39 ± 0.40 ms) and exists far more frequently in East Asians (0.46) than in Europeans and Africans (0.05 and 0.08, respectively). ..
  55. Russell R, Ilg M, Lin Q, Wu G, Lechel A, Bergmann W, et al. A Dynamic Role of TBX3 in the Pluripotency Circuitry. Stem Cell Reports. 2015;5:1155-1170 pubmed publisher
    ..b>TBX3 is the earliest expressed member of the T-box transcription factor family and is involved in maintenance and ..
  56. Hadjimichael C, Chanoumidou K, Nikolaou C, Klonizakis A, Theodosi G, Makatounakis T, et al. Promyelocytic Leukemia Protein Is an Essential Regulator of Stem Cell Pluripotency and Somatic Cell Reprogramming. Stem Cell Reports. 2017;8:1366-1378 pubmed publisher
    ..bodies, PML influences cell-fate decisions between mesoderm and endoderm by controlling the expression of Tbx3. PML loss compromises the reprogramming ability of embryonic fibroblasts to induced pluripotent stem cells by ..
  57. Bai Y, Feng M, Liu S, Wei H, Li L, Zhang X, et al. Differential gene expression in mouse spermatogonial stem cells and embryonic stem cells. Int J Mol Med. 2016;38:423-32 pubmed publisher
    ..Furthermore, the gene expression of N-Myc, Dppa2, Tbx3, Nr5a2, Prmt5, Tet3, Parp1, Max, Tert and Trf1 in the mSSCs (l) was markedly higher in comparison to that in the ..
  58. Hofstetter G, Concin N, Marth C, Rinne T, Erdel M, Janecke A. Genetic analyses in a variant of Mayer-Rokitansky-Kuster-Hauser syndrome (MURCS association). Wien Klin Wochenschr. 2008;120:435-9 pubmed publisher
    ..1 as well as the TBX5/TBX3 region at 12q24.1...
  59. Chen Z, Lv G, Ji T. [Tbx3 upregulation may be one of the malignant biomarkers of breast cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:765-7 pubmed
    To explore the role of abnormal Tbx3 expression in the pathogenesis of breast cancer. The total RNA of 4 breast cancer cell lines and 5 normal breast samples was extracted by routine Trizol method...
  60. Lüdtke T, Rudat C, Wojahn I, Weiss A, Kleppa M, Kurz J, et al. Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung. Dev Cell. 2016;39:239-253 pubmed publisher
    ..Here, we show by analysis of conditional double mutants that the two T-box transcription factor genes Tbx2 and Tbx3 act together in the lung mesenchyme to maintain branching morphogenesis...
  61. Wollnik B, Kayserili H, Uyguner O, Tukel T, Yuksel Apak M. Haploinsufficiency of TBX3 causes ulnar-mammary syndrome in a large Turkish family. Ann Genet. 2002;45:213-7 pubmed
    ..Mutation analysis of the TBX3 gene showed a novel one base-pair insertion at position 89 (designated 88_89insA) in the coding region...
  62. Zweier C, Sticht H, Aydin Yaylagül I, Campbell C, Rauch A. Human TBX1 missense mutations cause gain of function resulting in the same phenotype as 22q11.2 deletions. Am J Hum Genet. 2007;80:510-7 pubmed
    ..We therefore conclude that TBX1 gain-of-function mutations can result in the same phenotypic spectrum as haploinsufficiency caused by loss-of-function mutations or deletions. ..
  63. Christoffels V, Smits G, Kispert A, Moorman A. Development of the pacemaker tissues of the heart. Circ Res. 2010;106:240-54 pubmed publisher
    ..It will also shed light on the etiology of inborn and acquired errors of nodal tissues. ..
  64. Zhang J, He M, Qi Dong -, Xie W, Chen Y, Lin M, et al. Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression. Integr Cancer Ther. 2011;10:85-91 pubmed publisher
    ..Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were ..
  65. Ho J, Levy D, Rose L, Johnson A, Ridker P, Chasman D. Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study. J Hypertens. 2011;29:62-9 pubmed publisher
    ..Using this strategy, we report a newly identified blood pressure locus, BLK-GATA4, that may further understanding of the complex genetic pathways regulating blood pressure. ..
  66. Kato N, Takeuchi F, Tabara Y, Kelly T, Go M, Sim X, et al. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet. 2011;43:531-8 pubmed publisher
    ..included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all ..
  67. Martin N, Benhamed M, Nacerddine K, Demarque M, Van Lohuizen M, Dejean A, et al. Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J. 2012;31:95-109 pubmed publisher
    ..Collectively, our findings indicate that PML and TBX2 act in an autoregulatory loop to control the effective execution of the senescence program. ..
  68. Kandimalla R, van Tilborg A, Kompier L, Stumpel D, Stam R, Bangma C, et al. Genome-wide analysis of CpG island methylation in bladder cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic markers. Eur Urol. 2012;61:1245-56 pubmed publisher
    ..In the validation set, methylation of the T-box 2 (TBX2), T-box 3 (TBX3), GATA binding protein 2 (GATA2), and Zic family member 4 (ZIC4) genes was associated with progression to muscle-..
  69. Esmailpour T, Huang T. TBX3 promotes human embryonic stem cell proliferation and neuroepithelial differentiation in a differentiation stage-dependent manner. Stem Cells. 2012;30:2152-63 pubmed publisher
    T-box 3 (Tbx3) is a member of the T-box family of genes. Mutations that result in the haploinsufficiency of TBX3 cause ulnar mammary syndrome in humans characterized by mammary gland hypoplasia as well as other congenital defects...
  70. Zhao Z, Tian W, Wang L, Wang H, Qin X, Xing Q, et al. Genetic and functional analysis of the TBX3 gene promoter in indirect inguinal hernia. Gene. 2015;554:101-4 pubmed publisher
    ..b>TBX3 is a member of the T-box family of transcription factors that are essential to the embryonic development...
  71. Peres J, Kwesi Maliepaard E, Rambow F, Larue L, Prince S. The tumour suppressor, miR-137, inhibits malignant melanoma migration by targetting the TBX3 transcription factor. Cancer Lett. 2017;405:111-119 pubmed publisher
    The transcription factor, TBX3, is a key driver of malignant melanoma and any drug that impacts its expression is likely to have an impact on the treatment of this highly aggressive and treatment resistant cancer...
  72. Moreno Marín N, Barrasa E, Morales Hernández A, Paniagua B, Blanco Fernández G, Merino J, et al. Dioxin Receptor Adjusts Liver Regeneration After Acute Toxic Injury and Protects Against Liver Carcinogenesis. Sci Rep. 2017;7:10420 pubmed publisher
    ..Stem-like CK14 + and TBX3 + and pluripotency-expressing OCT4 + and NANOG + cells expanded sooner in AhR-/- than in AhR+/+ ..
  73. Yang L, Cai C, Lin L, Qyang Y, Chung C, Monteiro R, et al. Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006;133:1575-85 pubmed
    ..Bmp signaling in Isl1-expressing progenitors is required for expression of T-box transcription factors Tbx2 and Tbx3 in heart and limb. Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome...
  74. Levy D, Ehret G, Rice K, Verwoert G, Launer L, Dehghan A, et al. Genome-wide association study of blood pressure and hypertension. Nat Genet. 2009;41:677-87 pubmed publisher
    ..P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1)...
  75. Yoo N, Kim M, Lee S. Mutations in exon 2 of TBX3 are rare in common human tumors. APMIS. 2014;122:161-3 pubmed publisher
  76. Peres J, Prince S. The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion. Mol Cancer. 2013;12:117 pubmed publisher
    The T-box transcription factor, TBX3, is overexpressed in several cancers and has been proposed as a chemotherapeutic target...
  77. Liu Y, El Serag H, Jiao L, Lee J, Moore D, Franco L, et al. WNT signaling pathway gene polymorphisms and risk of hepatic fibrosis and inflammation in HCV-infected patients. PLoS ONE. 2013;8:e84407 pubmed publisher
    ..as the best interaction model for predicting risk of fibrosis; whereas race/ethnicity, FZD1 rs1346665, and TBX3 rs1520177 as the best interaction model for predicting risk of inflammation...
  78. Krstic M, MacMillan C, Leong H, Clifford A, Souter L, Dales D, et al. The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer. BMC Cancer. 2016;16:671 pubmed publisher
    b>TBX3 is a T-box transcription factor repressor that is elevated in metastatic breast cancer and is believed to promote malignancy of tumor cells, possibly by promoting cell survival and epithelial-mesenchymal transition...
  79. Komatsubara K, Jeter J, Carvajal R, Margolin K, Schadendorf D, Hauschild A. Advances in the Treatment of Advanced Extracutaneous Melanomas and Nonmelanoma Skin Cancers. Am Soc Clin Oncol Educ Book. 2017;37:641-650 pubmed publisher
    ..Similarly, less common extracutaneous melanomas, such as mucosal (MMs) and uveal (UMs), are unique biologic and clinical entities that require distinct diagnostic and management considerations...
  80. Li Z, Li X, Xu L, Tao Y, Yang C, Chen X, et al. Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4. Oncol Rep. 2017;38:2705-2716 pubmed publisher
    ..we screened the target genes of PAK4 by PCR array and found that 23 genes were upregulated (including TP53I3, TBX3, EEF1A2, CDKN1A, IFNB1 and MAPK8IP2) and 20 genes were downregulated (including TNFSF8, Bcl2-A1, Bcl2L1, SOCS3, ..
  81. Stevens K, Lindstrom S, Scott C, Thompson D, Sellers T, Wang X, et al. Identification of a novel percent mammographic density locus at 12q24. Hum Mol Genet. 2012;21:3299-305 pubmed publisher
    ..03 × 10(-8)). Rs1265507 is located between the genes TBX5 and TBX3, which are members of the phylogenetically conserved T-box gene family and encode transcription factors involved in ..
  82. Kumar P P, Franklin S, Emechebe U, Hu H, Moore B, Lehman C, et al. TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome. PLoS Genet. 2014;10:e1004247 pubmed publisher
    b>TBX3 is a member of the T-box family of transcription factors with critical roles in development, oncogenesis, cell fate, and tissue homeostasis. TBX3 mutations in humans cause complex congenital malformations and Ulnar-mammary syndrome...
  83. Verweij N, Mateo Leach I, van den Boogaard M, van Veldhuisen D, Christoffels V, Hillege H, et al. Genetic determinants of P wave duration and PR segment. Circ Cardiovasc Genet. 2014;7:475-81 pubmed publisher
    ..Through genome-wide association we also identified genetic variants specifically associated with P wave duration which might be relevant for cardiac biology. ..
  84. Wensing L, Campos A. TBX3, a downstream target of TGF-β1, inhibits mesangial cell apoptosis. Exp Cell Res. 2014;328:340-50 pubmed publisher
    ..Here we show that TGF-β1 regulates TBX3 gene expression in MC. This gene encodes for two main isoforms, TBX3.1 and TBX3+2α. TBX3...
  85. Wang H, Meng Q, Shan Z, Yuan Z, Huang X. Overexpression of Tbx3 predicts poor prognosis of patients with resectable pancreatic carcinoma. Asian Pac J Cancer Prev. 2015;16:1397-401 pubmed
    To determine the expressions of Tbx3, a member of subgroup belonging to T-box family, and its prognostic value in pancreatic carcinoma...
  86. Sano M, Kamitsuji S, Kamatani N, Tabara Y, Kawaguchi T, Matsuda F, et al. Genome-Wide Association Study of Absolute QRS Voltage Identifies Common Variants of TBX3 as Genetic Determinants of Left Ventricular Mass in a Healthy Japanese Population. PLoS ONE. 2016;11:e0155550 pubmed publisher
    ..voltage in Japanese individuals and SNP rs7301743[G], which maps near the gene encoding T-box transcription factor Tbx3. Meta-analysis of two independent Japanese datasets demonstrated a marginally significant association of SNP ..
  87. Chen L, Deng Z, Zhou J, Ji R, Zhang X, Zhang C, et al. Tbx18-dependent differentiation of brown adipose tissue-derived stem cells toward cardiac pacemaker cells. Mol Cell Biochem. 2017;433:61-77 pubmed publisher
    ..The expression of Tbx3 and shox2, the other two important transcription factors in the development of pacemaker cells, was decreased by ..
  88. Hong K, Jin H, Lim J, Kim S, Go M, Oh B. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. J Hum Genet. 2010;55:336-41 pubmed publisher
  89. Gudmundsson J, Besenbacher S, Sulem P, Gudbjartsson D, Olafsson I, Arinbjarnarson S, et al. Genetic correction of PSA values using sequence variants associated with PSA levels. Sci Transl Med. 2010;2:62ra92 pubmed publisher
    ..We propose that a personalized PSA cutoff value, based on genotype, should be used when deciding to perform a prostate biopsy. ..
  90. Joss S, Kini U, Fisher R, Mundlos S, Prescott K, Newbury Ecob R, et al. The face of Ulnar Mammary syndrome?. Eur J Med Genet. 2011;54:301-5 pubmed publisher
    Ulnar Mammary syndrome (UMS) is an autosomal disorder caused by haploinsufficiency of the TBX3 gene. There is marked intrafamilial variation in expression of the syndrome...
  91. Burgucu D, Guney K, Sahinturk D, Ozbudak I, Ozel D, Ozbilim G, et al. Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma. BMC Cancer. 2012;12:481 pubmed publisher
    ..Tbx2 and Tbx3, both of which are transcriptional repressors, have been found to be amplified or over-expressed in various cancer ..
  92. Li J, Weinberg M, Zerbini L, Prince S. The oncogenic TBX3 is a downstream target and mediator of the TGF-?1 signaling pathway. Mol Biol Cell. 2013;24:3569-76 pubmed publisher
    The T-box transcription factor, TBX3, plays an important role in embryonic development, and haploinsufficiency of TBX3 causes ulnar-mammary syndrome...