Gene Symbol: TBC1D14
Description: TBC1 domain family member 14
Alias: TBC1 domain family member 14
Fuchs E, Haas A, Spooner R, Yoshimura S, Lord J, Barr F. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol. 2007;177:1133-43 pubmed
..These results suggest that Shiga toxin trafficking to the Golgi is a multistep process controlled by several Rab GAPs and their target Rabs and that this process is discrete from ligand-induced EGF receptor trafficking. ..
Tempel W, Tong Y, Dimov S, Bochkarev A, Park H. First crystallographic models of human TBC domains in the context of a family-wide structural analysis. Proteins. 2008;71:497-502 pubmed publisher
Oguchi M, Noguchi K, Fukuda M. TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells. PLoS ONE. 2017;12:e0174883 pubmed publisher
..Four of the 43 mammalian TBC proteins screened, i.e., TBC1D11, TBC1D12, TBC1D14, and EVI5, were found to colocalize well with transferrin receptor, a well-known recycling endosome marker...
Longatti A, Lamb C, Razi M, Yoshimura S, Barr F, Tooze S. TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. J Cell Biol. 2012;197:659-75 pubmed publisher
..One of these putative RabGAPs, TBC1D14, colocalizes and interacts with the autophagy kinase ULK1...
Lamb C, NÃ¼hlen S, Judith D, Frith D, Snijders A, Behrends C, et al
. TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic. EMBO J. 2016;35:281-301 pubmed publisher
..We have previously identified the TBC domain-containing protein, TBC1D14, as a negative regulator of autophagy that controls delivery of membranes from RAB11-positive recycling endosomes ..