TBC1D14

Summary

Gene Symbol: TBC1D14
Description: TBC1 domain family member 14
Alias: TBC1 domain family member 14
Species: human
Products:     TBC1D14

Top Publications

  1. Fuchs E, Haas A, Spooner R, Yoshimura S, Lord J, Barr F. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol. 2007;177:1133-43 pubmed
    ..These results suggest that Shiga toxin trafficking to the Golgi is a multistep process controlled by several Rab GAPs and their target Rabs and that this process is discrete from ligand-induced EGF receptor trafficking. ..
  2. Tempel W, Tong Y, Dimov S, Bochkarev A, Park H. First crystallographic models of human TBC domains in the context of a family-wide structural analysis. Proteins. 2008;71:497-502 pubmed publisher
  3. Oguchi M, Noguchi K, Fukuda M. TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells. PLoS ONE. 2017;12:e0174883 pubmed publisher
    ..Four of the 43 mammalian TBC proteins screened, i.e., TBC1D11, TBC1D12, TBC1D14, and EVI5, were found to colocalize well with transferrin receptor, a well-known recycling endosome marker...
  4. Longatti A, Lamb C, Razi M, Yoshimura S, Barr F, Tooze S. TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. J Cell Biol. 2012;197:659-75 pubmed publisher
    ..One of these putative RabGAPs, TBC1D14, colocalizes and interacts with the autophagy kinase ULK1...
  5. Lamb C, Nühlen S, Judith D, Frith D, Snijders A, Behrends C, et al. TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic. EMBO J. 2016;35:281-301 pubmed publisher
    ..We have previously identified the TBC domain-containing protein, TBC1D14, as a negative regulator of autophagy that controls delivery of membranes from RAB11-positive recycling endosomes ..