tau

Summary

Gene Symbol: tau
Description: microtubule associated protein tau
Alias: DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule-associated protein tau, G protein beta1/gamma2 subunit-interacting factor 1, PHF-tau, neurofibrillary tangle protein, paired helical filament-tau, protein phosphatase 1, regulatory subunit 103
Species: human
Products:     tau

Top Publications

  1. Van der Jeugd A, Hochgräfe K, Ahmed T, Decker J, Sydow A, Hofmann A, et al. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathol. 2012;123:787-805 pubmed publisher
    Neurofibrillary lesions of abnormal Tau are hallmarks of Alzheimer disease and frontotemporal dementias...
  2. Höglinger G, Melhem N, Dickson D, Sleiman P, Wang L, Klei L, et al. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nat Genet. 2011;43:699-705 pubmed publisher
    Progressive supranuclear palsy (PSP) is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease...
  3. Ferreira A, Bigio E. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Mol Med. 2011;17:676-85 pubmed publisher
    b>Tau dysfunction has been associated with a host of neurodegenerative diseases called tauopathies...
  4. Beck J, Rohrer J, Campbell T, Isaacs A, Morrison K, Goodall E, et al. A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. Brain. 2008;131:706-20 pubmed publisher
    ..in the progranulin gene (GRN) are a major cause of frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions (FTLD-U) but the distinguishing clinical and anatomical features of this subgroup remain ..
  5. Bunker J, Wilson L, Jordan M, Feinstein S. Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration. Mol Biol Cell. 2004;15:2720-8 pubmed
    The neural microtubule-associated protein tau binds to and stabilizes microtubules. Because of alternative mRNA splicing, tau is expressed with either 3 or 4 C-terminal repeats...
  6. Iovino M, Patani R, Watts C, Chandran S, Spillantini M. Human stem cell-derived neurons: a system to study human tau function and dysfunction. PLoS ONE. 2010;5:e13947 pubmed publisher
    Intracellular filamentous deposits containing microtubule-associated protein tau constitute a defining characteristic of many neurodegenerative disorders...
  7. Mata I, Yearout D, Alvarez V, Coto E, De Mena L, Ribacoba R, et al. Replication of MAPT and SNCA, but not PARK16-18, as susceptibility genes for Parkinson's disease. Mov Disord. 2011;26:819-23 pubmed publisher
    ..Our findings suggest that additional studies of PARK16-18 are necessary to establish the role of these loci in modifying risk for Parkinson's disease in European-derived populations. © 2011 Movement Disorder Society. ..
  8. Coppola G, Chinnathambi S, Lee J, Dombroski B, Baker M, Soto Ortolaza A, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012;21:3500-12 pubmed publisher
    Rare mutations in the gene encoding for tau (MAPT, microtubule-associated protein tau) cause frontotemporal dementia-spectrum (FTD-s) disorders, including FTD, progressive supranuclear palsy (PSP) and corticobasal syndrome, and a common ..
  9. Nalls M, Plagnol V, Hernandez D, Sharma M, Sheerin U, Saad M, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet. 2011;377:641-9 pubmed publisher
    ..These data provide an insight into the genetics of Parkinson's disease and the molecular cause of the disease and could provide future targets for therapies. Wellcome Trust, National Institute on Aging, and US Department of Defense. ..

More Information

Publications86

  1. Spencer C, Plagnol V, Strange A, Gardner M, Paisan Ruiz C, Band G, et al. Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet. 2011;20:345-53 pubmed publisher
    ..We found no support for the previously reported SNP association in 12q12/LRRK2. We also found an association of the two SNPs in 4q22/SNCA with the age of onset of the disease. ..
  2. Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. J Alzheimers Dis. 2012;28:377-87 pubmed publisher
    ..However, the gene-wide effect observed at MAPT indicates a possible contribution to disease risk which requires further study. ..
  3. Simón Sánchez J, Schulte C, Bras J, Sharma M, Gibbs J, Berg D, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009;41:1308-12 pubmed publisher
    ..14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease. ..
  4. Smoter M, Bodnar L, Grala B, Stec R, Zieniuk K, Kozlowski W, et al. Tau protein as a potential predictive marker in epithelial ovarian cancer patients treated with paclitaxel/platinum first-line chemotherapy. J Exp Clin Cancer Res. 2013;32:25 pubmed publisher
    The aim of the study was to evaluate predictive and prognostic significance of microtubule-associated protein Tau in epithelial ovarian cancer (EOC) patients treated with paclitaxel and platinum-based chemotherapy.
  5. Flach K, Hilbrich I, Schiffmann A, Gärtner U, Krüger M, Leonhardt M, et al. Tau oligomers impair artificial membrane integrity and cellular viability. J Biol Chem. 2012;287:43223-33 pubmed publisher
    The microtubule-associated protein Tau is mainly expressed in neurons, where it binds and stabilizes microtubules. In Alzheimer disease and other tauopathies, Tau protein has a reduced affinity toward microtubules...
  6. Sahara N, Deture M, Ren Y, Ebrahim A, Kang D, Knight J, et al. Characteristics of TBS-extractable hyperphosphorylated tau species: aggregation intermediates in rTg4510 mouse brain. J Alzheimers Dis. 2013;33:249-63 pubmed publisher
    Conditional overexpression of four-repeat human tau containing the P301L missense mutation in the rTg4510 mouse model of tauopathy leads to progressive accumulation of neurofibrillary tangles and hyperphosphorylated, sarkosyl-insoluble ..
  7. Hinrichs M, Jalal A, Brenner B, Mandelkow E, Kumar S, Scholz T. Tau protein diffuses along the microtubule lattice. J Biol Chem. 2012;287:38559-68 pubmed publisher
    Current models for the intracellular transport of Tau protein suggest motor protein-dependent co-transport with microtubule fragments and diffusion of Tau in the cytoplasm, whereas Tau is believed to be stationary while bound to ..
  8. Wegmann S, Medalsy I, Mandelkow E, Müller D. The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush. Proc Natl Acad Sci U S A. 2013;110:E313-21 pubmed publisher
    The structure and properties of amyloid-like Tau fibrils accumulating in neurodegenerative diseases have been debated for decades...
  9. Meng S, Zhu Y, Guo T, Liu X, Chen J, Liang Y. Fibril-forming motifs are essential and sufficient for the fibrillization of human Tau. PLoS ONE. 2012;7:e38903 pubmed publisher
    The misfolding of amyloidogenic proteins including human Tau protein, human prion protein, and human ?-synuclein is involved in neurodegenerative diseases such as Alzheimer disease, prion disease, and Parkinson disease...
  10. Kimura T, Tsutsumi K, Taoka M, Saito T, Masuda Suzukake M, Ishiguro K, et al. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. J Biol Chem. 2013;288:7968-77 pubmed publisher
    Neurodegenerative diseases associated with the pathological aggregation of microtubule-associated protein Tau are classified as tauopathies...
  11. Mondragón Rodríguez S, Trillaud Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, et al. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. J Biol Chem. 2012;287:32040-53 pubmed publisher
    Amyloid-? and tau protein are the two most prominent factors in the pathology of Alzheimer disease. Recent studies indicate that phosphorylated tau might affect synaptic function...
  12. Bloom G. Amyloid-? and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol. 2014;71:505-8 pubmed publisher
    ..The soluble building blocks of these structures are amyloid-? (A?) peptides for plaques and tau for tangles...
  13. Colom Cadena M, Gelpi E, Marti M, Charif S, Dols Icardo O, Blesa R, et al. MAPT H1 haplotype is associated with enhanced ?-synuclein deposition in dementia with Lewy bodies. Neurobiol Aging. 2013;34:936-42 pubmed publisher
    The microtubule-associated protein tau (MAPT) H1 haplotype has been identified as a genetic risk factor for synucleinopathies. However, whether it modulates tau or ?-synuclein pathology remains unknown...
  14. Merino Serrais P, Benavides Piccione R, Blazquez Llorca L, Kastanauskaite A, Rabano A, Avila J, et al. The influence of phospho-? on dendritic spines of cortical pyramidal neurons in patients with Alzheimer's disease. Brain. 2013;136:1913-28 pubmed publisher
    ..Following intracellular injection, sections were immunostained for anti-Lucifer yellow and with tau monoclonal antibodies AT8 and PHF-1, which recognize tau phosphorylated at Ser202/Thr205 and at Ser396/404, ..
  15. Stoeck K, Sanchez Juan P, Gawinecka J, Green A, Ladogana A, Pocchiari M, et al. Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years. Brain. 2012;135:3051-61 pubmed publisher
    ..dementia diagnoses, their potential influence on 14-3-3 specificity as well as results of other dementia markers (tau, phosphorylated tau and amyloid-?(1-42)) and evaluated the specificity of 14-3-3 in Creutzfeldt-Jakob disease ..
  16. Lee S, Tartaglia M, Yener G, Genc S, Seeley W, Sanchez Juan P, et al. Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease. Alzheimer Dis Assoc Disord. 2013;27:302-9 pubmed publisher
    Recently, Coppola and colleagues demonstrated that a rare microtubule-associated protein tau (MAPT) sequence variant, c.454G>A (p...
  17. Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang Y. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proc Natl Acad Sci U S A. 2013;110:4604-9 pubmed publisher
    ..disease (AD) and related tauopathy patients contain neurofibrillary tangles composed of hyperphosphorylated tau protein...
  18. Wang Q, Wang N, Shao G, QIAN J, Shen D, Fei Y, et al. Relationship between gastric cancer tau protein expression and paclitaxel sensitivity. Pathol Oncol Res. 2013;19:429-35 pubmed publisher
    The abnormal expression of Tau protein in breast cancer tissue affects paclitaxel sensitivity. The abnormal expression also exists in gastric carcinoma...
  19. Combs B, Gamblin T. FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions. Biochemistry. 2012;51:8597-607 pubmed publisher
    FTDP-17 mutations in the tau gene lead to early onset frontotemporal dementias characterized by the pathological aggregation of the microtubule-associated protein tau...
  20. Duan A, Goodson H. Taxol-stabilized microtubules promote the formation of filaments from unmodified full-length Tau in vitro. Mol Biol Cell. 2012;23:4796-806 pubmed publisher
    b>Tau is a neuronal protein that stabilizes the microtubule (MT) network, but it also forms filaments associated with Alzheimer's disease...
  21. Killick R, Ribe E, Al Shawi R, Malik B, Hooper C, Fernandes C, et al. Clusterin regulates ?-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry. 2014;19:88-98 pubmed publisher
    ..and KLF10 (Krüppel-like factor-10) that, when individually silenced, protected against A? neurotoxicity and/or tau phosphorylation...
  22. Chabrier M, Cheng D, Castello N, Green K, LaFerla F. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiol Dis. 2014;64:107-17 pubmed publisher
    ..the best indicator of cognitive impairment In Alzheimer's disease (AD), yet the respective contributions of A? and tau, particularly human wild-type tau, to synapse loss remain undefined...
  23. Richet E, Pooler A, Rodriguez T, Novoselov S, Schmidtke G, Groettrup M, et al. NUB1 modulation of GSK3? reduces tau aggregation. Hum Mol Genet. 2012;21:5254-67 pubmed publisher
    Abnormal phosphorylation of the microtubule-associated protein tau in neurodegenerative disorders, including Alzheimer's disease (AD) and frontotemporal lobar degeneration, is associated with disrupted axonal transport and synaptic ..
  24. Tai H, Serrano Pozo A, Hashimoto T, Frosch M, Spires Jones T, Hyman B. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am J Pathol. 2012;181:1426-35 pubmed publisher
    ..Tangles are composed of misfolded hyperphosphorylated tau proteins; however, the link between tau abnormalities and synaptic dysfunction remains unclear...
  25. Pooler A, Noble W, Hanger D. A role for tau at the synapse in Alzheimer's disease pathogenesis. Neuropharmacology. 2014;76 Pt A:1-8 pubmed publisher
    Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau neurofibrillary tangles along with steady cognitive decline...
  26. Héraud C, Goufak D, Ando K, Leroy K, Suain V, Yilmaz Z, et al. Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice. Neurobiol Dis. 2014;62:100-12 pubmed publisher
    ..The mechanisms leading to this enhanced tau pathology are not well understood...
  27. Daebel V, Chinnathambi S, Biernat J, Schwalbe M, Habenstein B, Loquet A, et al. ?-Sheet core of tau paired helical filaments revealed by solid-state NMR. J Am Chem Soc. 2012;134:13982-9 pubmed publisher
    One of the hallmarks of Alzheimer's disease is the self-assembly of the microtubule-associated protein tau into fibers termed "paired helical filaments" (PHFs)...
  28. Gu G, Wu D, Lund H, Sunnemark D, Kvist A, Milner R, et al. Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease. J Alzheimers Dis. 2013;33:699-713 pubmed publisher
    ..of Alzheimer's disease (AD), is most likely caused by inappropriate phosphorylation and/or dephosphorylation of tau, eventually leading to the accumulation of NFTs...
  29. Ando K, Brion J, Stygelbout V, Suain V, Authelet M, Dedecker R, et al. Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol. 2013;125:861-78 pubmed publisher
    ..in situ with neurofibrillary tangles, co-localising with conformationally abnormal and hyperphosphorylated tau in LOAD, familial AD and Down syndrome cases. PHF-tau proteins co-immunoprecipitated with PICALM...
  30. Furgerson M, Fechheimer M, Furukawa R. Model Hirano bodies protect against tau-independent and tau-dependent cell death initiated by the amyloid precursor protein intracellular domain. PLoS ONE. 2012;7:e44996 pubmed publisher
    ..plaques and neurofibrillary tangles, which are primarily composed of amyloid precursor protein (APP) and tau, respectively. These proteins and their role in the mechanism of neurodegeneration have been extensively studied...
  31. Trabzuni D, Wray S, Vandrovcova J, Ramasamy A, Walker R, Smith C, et al. MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Hum Mol Genet. 2012;21:4094-103 pubmed publisher
    The MAPT (microtubule-associated protein tau) locus is one of the most remarkable in neurogenetics due not only to its involvement in multiple neurodegenerative disorders, including progressive supranuclear palsy, corticobasal ..
  32. Chien D, Bahri S, Szardenings A, Walsh J, Mu F, Su M, et al. Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. J Alzheimers Dis. 2013;34:457-68 pubmed publisher
    Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease...
  33. Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen K, et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry. 2013;18:1225-34 pubmed publisher
    ..14-1.26) (P=3.8 × 10(-11))). Interestingly, decreased expression of the Drosophila BIN1 ortholog Amph suppressed Tau-mediated neurotoxicity in three different assays...
  34. Luk C, Compta Y, Magdalinou N, Marti M, Hondhamuni G, Zetterberg H, et al. Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three- and four-repeat tau isoforms in tauopathies. J Neurochem. 2012;123:396-405 pubmed publisher
    Characteristic tau isoform composition of the insoluble fibrillar tau inclusions define tauopathies, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and frontotemporal dementia with parkinsonism linked to ..
  35. King A, Al Sarraj S, Troakes C, Smith B, Maekawa S, Iovino M, et al. Mixed tau, TDP-43 and p62 pathology in FTLD associated with a C9ORF72 repeat expansion and p.Ala239Thr MAPT (tau) variant. Acta Neuropathol. 2013;125:303-10 pubmed publisher
    ..Ala239Thr variant in MAPT (microtubule associated protein tau) gene not previously associated with tau pathology...
  36. Sanders D, Kaufman S, DeVos S, Sharma A, Mirbaha H, Li A, et al. Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron. 2014;82:1271-88 pubmed publisher
    Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies...
  37. Cavallini A, Brewerton S, Bell A, Sargent S, Glover S, Hardy C, et al. An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease. J Biol Chem. 2013;288:23331-47 pubmed publisher
    ..the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia...
  38. Irwin D, Lee V, Trojanowski J. Parkinson's disease dementia: convergence of ?-synuclein, tau and amyloid-? pathologies. Nat Rev Neurosci. 2013;14:626-36 pubmed publisher
    ..In addition, up to 50% of patients with PDD also develop sufficient numbers of amyloid-? plaques and tau-containing neurofibrillary tangles for a secondary diagnosis of Alzheimer's disease, and these pathologies may act ..
  39. Scholz T, Mandelkow E. Transport and diffusion of Tau protein in neurons. Cell Mol Life Sci. 2014;71:3139-50 pubmed publisher
    In highly polarized and elongated cells such as neurons, Tau protein must enter and move down the axon to fulfill its biological task of stabilizing axonal microtubules...
  40. He W, Zhang D, Jiang J, Liu P, Wu C. The relationships between the chemosensitivity of human gastric cancer to paclitaxel and the expressions of class III ?-tubulin, MAPT, and survivin. Med Oncol. 2014;31:950 pubmed publisher
    ..out to investigate the relationships between the expressions of class III ?-tubulin, microtubule-associated protein tau (MAPT), survivin, and the sensitivity of primary gastric cancer (GC) to paclitaxel treatment...
  41. Yin X, Jin N, Gu J, Shi J, Zhou J, Gong C, et al. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. J Biol Chem. 2012;287:30497-506 pubmed publisher
    b>Tau exon 10, which encodes the second microtubule-binding repeat, is regulated by alternative splicing. Its alternative splicing generates Tau isoforms with three- or four-microtubule-binding repeats, named 3R-tau and 4R-tau...
  42. Chai X, Dage J, Citron M. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiol Dis. 2012;48:356-66 pubmed publisher
    The microtubule-associated protein tau plays a critical role in the pathogenesis of Alzheimer's disease and several related disorders...
  43. Kumar S, Tepper K, Kaniyappan S, Biernat J, Wegmann S, Mandelkow E, et al. Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity. J Biol Chem. 2014;289:20318-32 pubmed publisher
    Several neurodegenerative diseases are characterized by the aggregation and posttranslational modifications of Tau protein...
  44. Michel C, Kumar S, Pinotsi D, Tunnacliffe A, St George Hyslop P, Mandelkow E, et al. Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology. J Biol Chem. 2014;289:956-67 pubmed publisher
    Understanding the formation and propagation of aggregates of the Alzheimer disease-associated Tau protein in vivo is vital for the development of therapeutics for this devastating disorder...
  45. Spillantini M, Goedert M. Tau pathology and neurodegeneration. Lancet Neurol. 2013;12:609-22 pubmed publisher
    The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and filamentous tau protein is at the centre of many human neurodegenerative diseases, collectively referred to as tauopathies...
  46. Karch C, Jeng A, Goate A. Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies. J Biol Chem. 2012;287:42751-62 pubmed publisher
    Tauopathies are a class of neurodegenerative diseases marked by intracellular aggregates of hyperphosphorylated Tau. These diseases may occur by sporadic mechanisms in which genetic variants represent risk factors for disease, as is the ..
  47. Rossi G, Conconi D, Panzeri E, Redaelli S, Piccoli E, Paoletta L, et al. Mutations in MAPT gene cause chromosome instability and introduce copy number variations widely in the genome. J Alzheimers Dis. 2013;33:969-82 pubmed publisher
    ..main function of promoting polymerization and stabilization of microtubules, other roles are being attributed to tau, now considered a multifunctional protein...
  48. Schindowski K, Bretteville A, Leroy K, Bégard S, Brion J, Hamdane M, et al. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol. 2006;169:599-616 pubmed
    b>Tau transgenic mice are valuable models to investigate the role of tau protein in Alzheimer's disease and other tauopathies...
  49. Jensen P, Hager H, Nielsen M, Hojrup P, Gliemann J, Jakes R. alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J Biol Chem. 1999;274:25481-9 pubmed
    ..The microtubule-associated protein tau was identified as a ligand by alpha-synuclein affinity chromatography of human brain cytosol...
  50. Russ C, Powell J, Zhao J, Baker M, Hutton M, Crawford F, et al. The microtubule associated protein Tau gene and Alzheimer's disease--an association study and meta-analysis. Neurosci Lett. 2001;314:92-6 pubmed
    Several studies have suggested an association between polymorphisms and an extended haplotype of the microtubule associated protein tau gene and Alzheimer's disease (AD) in synergy with apolipoprotein E (APOE) epsilon 4 status...
  51. Glatz D, Rujescu D, Tang Y, Berendt F, Hartmann A, Faltraco F, et al. The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease. J Neurochem. 2006;96:635-44 pubmed
    Pathological inclusions containing fibrillar aggregates of hyperphosphorylated tau protein are a characteristic feature in tauopathies, which include Alzheimer's disease (AD)...
  52. Wegiel J, Kaczmarski W, Barua M, Kuchna I, Nowicki K, Wang K, et al. Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. J Neuropathol Exp Neurol. 2011;70:36-50 pubmed publisher
    ..DYRK1A phosphorylates cytoplasmic tau protein and appears in intraneuronal neurofibrillary tangles (NFTs)...
  53. van Harten A, Kester M, Visser P, Blankenstein M, Pijnenburg Y, van der Flier W, et al. Tau and p-tau as CSF biomarkers in dementia: a meta-analysis. Clin Chem Lab Med. 2011;49:353-66 pubmed publisher
    To evaluate the value of total tau (tau) and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) in the differential diagnosis of dementia, more specifically: dementia with Lewy Bodies (DLB), frontotemporal lobar degeneration (FTLD), ..
  54. Ittner L, Ke Y, Götz J. Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem. 2009;284:20909-16 pubmed publisher
    In Alzheimer disease (AD) and frontotemporal dementia the microtubule-associated protein Tau becomes progressively hyperphosphorylated, eventually forming aggregates...
  55. Fidani L, Kalinderi K, Bostantjopoulou S, Clarimon J, Goulas A, Katsarou Z, et al. Association of the Tau haplotype with Parkinson's disease in the Greek population. Mov Disord. 2006;21:1036-9 pubmed
    We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece...
  56. Nacharaju P, Lewis J, Easson C, Yen S, Hackett J, Hutton M, et al. Accelerated filament formation from tau protein with specific FTDP-17 missense mutations. FEBS Lett. 1999;447:195-9 pubmed
    b>Tau is the major component of the neurofibrillar tangles that are a pathological hallmark of Alzheimers' disease...
  57. Poorkaj P, Grossman M, Steinbart E, Payami H, Sadovnick A, Nochlin D, et al. Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. Arch Neurol. 2001;58:383-7 pubmed
    Mutations in the tau gene have been reported in families with frontotemporal dementia (FTD) linked to chromosome 17...
  58. Ribe E, Perez M, Puig B, Gich I, Lim F, Cuadrado M, et al. Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice. Neurobiol Dis. 2005;20:814-22 pubmed
    ..has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this type of dementia remains controversial...
  59. Huang D, Weisgraber K, Goedert M, Saunders A, Roses A, Strittmatter W. ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neurosci Lett. 1995;192:209-12 pubmed
    ..Isoform specific interactions of ApoE have been shown with the microtubule-associated protein tau, which forms the neurofibrillary tangle in this disease...
  60. Frost B, Ollesch J, Wille H, Diamond M. Conformational diversity of wild-type Tau fibrils specified by templated conformation change. J Biol Chem. 2009;284:3546-51 pubmed publisher
    ..sporadic and genetic neurodegenerative diseases characterized by aggregation of the microtubule-associated protein Tau. Tau pathology occurs in over 20 phenotypically distinct neurodegenerative diseases, including Alzheimer disease ..
  61. Morley J, Xie S, Hurtig H, Stern M, Colcher A, Horn S, et al. Genetic influences on cognitive decline in Parkinson's disease. Mov Disord. 2012;27:512-8 pubmed publisher
    ..We examined whether variations in apolipoprotein E (APOE), microtubule-associated protein tau (MAPT), or catechol-O-methytransferase (COMT) genotypes are associated with cognitive decline in PD...
  62. Lu P, Wulf G, Zhou X, Davies P, Lu K. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature. 1999;399:784-8 pubmed
    ..tangle, which contains paired helical filaments (PHFs) composed of the microtubule-associated protein tau. Tau is hyperphosphorylated in PHFs, and phosphorylation of tau abolishes its ability to bind microtubules and ..
  63. Refenes N, Bolbrinker J, Tagaris G, Orlacchio A, Drakoulis N, Kreutz R. Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson's disease. BMC Neurol. 2009;9:26 pubmed publisher
    The extended tau haplotype (H1) that covers the entire human microtubule-associated protein tau (MAPT) gene has been implicated in Parkinson's disease (PD)...
  64. Schweers O, Schönbrunn Hanebeck E, Marx A, Mandelkow E. Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure. J Biol Chem. 1994;269:24290-7 pubmed
    We have studied the conformation of tau protein and Alzheimer paired helical filaments (PHF) by several spectroscopic, scattering, and imaging methods revealing the overall shape and the conformation of the polypeptide backbone...
  65. Goedert M, Spillantini M, Potier M, Ulrich J, Crowther R. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J. 1989;8:393-9 pubmed
    We have isolated cDNA clones encoding a 383-amino acid isoform of the human microtubule-associated protein tau. It differs from previously determined tau sequences by the presence of an additional repeat of 31 amino acids, giving four, ..
  66. Hasegawa M, Morishima Kawashima M, Takio K, Suzuki M, Titani K, Ihara Y. Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain. J Biol Chem. 1992;267:17047-54 pubmed
    b>Tau with unusually slow mobilities in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was purified from the Sarkosyl-insoluble pellet of Alzheimer's disease brain homogenates...
  67. Duda J, Giasson B, Mabon M, Miller D, Golbe L, Lee V, et al. Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred. Acta Neuropathol. 2002;104:7-11 pubmed
    ..Immunoelectron microscopy demonstrated fibrillar alpha-synuclein-immunoreactive aggregates. Unexpected tau neuritic and less frequent perikaryal inclusions were also observed...
  68. Ingelson M, Fabre S, Lilius L, Andersen C, Viitanen M, Almkvist O, et al. Increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein E epsilon4. Neuroreport. 2001;12:905-9 pubmed
    The tau gene has an important role in frontotemporal dementia (FTD) as pathogenic mutations have been found in hereditary forms of the disease...
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    We have previously demonstrated in a transgenic rat model of tauopathy that human misfolded truncated tau derived from Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo...
  70. Tsuboi Y. [Clinical, pathological, and genetic characteristics of frontotemporal dementia and parkinsonism linked to chromosome 17 with mutations in the MAPT and PGRN]. Brain Nerve. 2009;61:1285-91 pubmed
    ..dementia and parkinsonism linked to chromosome 17 (FTDP-17) with mutations in microtubule-associated protein tau (MAPT) and progranulin (PGRN). Research on FTDP-17 has greatly progressed over the years...
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    The microtubule-associated protein tau is able to interact with actin and serves as a cross-linker between the microtubule and actin networks. The microtubule-binding domain of tau is known to be involved in its interaction with actin...
  72. Sze C, Su M, Pugazhenthi S, Jambal P, Hsu L, Heath J, et al. Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. J Biol Chem. 2004;279:30498-506 pubmed
    Numerous enzymes hyperphosphorylate Tau in vivo, leading to the formation of neurofibrillary tangles (NFTs) in the neurons of Alzheimer's disease (AD)...
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    Cognitive demise correlates with progressive brain tauopathy in dementing patients. Improved cognition of young Tau.P301L mice contrasts with dysfunction later in life and remains unexplained (Boekhoorn et al., 2006)...
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    Hyperphosphorylation of the microtubule associated protein tau is detected in the brains of individuals with a range of neurodegenerative diseases including Alzheimer's disease (AD)...
  75. Rossi G, Dalprà L, Crosti F, Lissoni S, Sciacca F, Catania M, et al. A new function of microtubule-associated protein tau: involvement in chromosome stability. Cell Cycle. 2008;7:1788-94 pubmed
    b>Tau is a microtubule-associated protein that promotes assembly and stabilization of cytoskeleton microtubules...
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    ..Here, we provide in vitro and in vivo evidence that HDAC6 interacts with tau, a microtubule-associated protein that forms neurofibrillary tangles in Alzheimer's disease...
  77. Folwell J, Cowan C, Ubhi K, Shiabh H, Newman T, Shepherd D, et al. Abeta exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease. Exp Neurol. 2010;223:401-9 pubmed publisher
    Alzheimer's disease (AD) is characterised by neurofibrillary tangles composed of hyper-phosphorylated tau, and neuritic plaques composed of misfolded amyloid peptide (Abeta(42))...