TAS2R4

Summary

Gene Symbol: TAS2R4
Description: taste receptor, type 2, member 4
Alias: T2R4, candidate taste receptor T2R4, taste receptor type 2 member 4
Species: human

Top Publications

  1. ncbi T2Rs function as bitter taste receptors
    J Chandrashekar
    Howard Hughes Medical Institute and Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Cell 100:703-11. 2000
  2. ncbi The good taste of genomics
    S Firestein
    Nature 404:552-3. 2000
  3. ncbi A family of candidate taste receptors in human and mouse
    H Matsunami
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 404:601-4. 2000
  4. ncbi A plethora of taste receptors
    S C Kinnamon
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA
    Neuron 25:507-10. 2000
  5. ncbi Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting
    T Ueda
    Department of Anatomy and Neuroscience, Nagoya City University Medical School, Nagoya, Japan
    Biochem Biophys Res Commun 285:147-51. 2001
  6. ncbi Functional expression of mammalian bitter taste receptors in Caenorhabditis elegans
    C Conte
    Neuroscience, Pharma Research, F Hoffmann La Roche, Basel 4070, Switzerland
    Biochimie 88:801-6. 2006
  7. ncbi Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults
    John E Hayes
    Department of Food Science, College of Agricultural Sciences, The Pennsylvania State University, 220 Food Science Building, University Park, PA 16802, USA
    Chem Senses 36:311-9. 2011
  8. ncbi Functional bitter taste receptors are expressed in brain cells
    Nisha Singh
    Department of Oral Biology, University of Manitoba, Winnipeg, MB, Canada R3E 0W2
    Biochem Biophys Res Commun 406:146-51. 2011

Scientific Experts

  • C Conte
  • Takashi Ueda
  • S C Kinnamon
  • John E Hayes
  • Nisha Singh
  • Fiona Parkinson
  • Linda M Bartoshuk
  • Maria Vrontakis
  • Valerie S Knopik
  • Valerie B Duffy
  • Margaret R Wallace
  • Prashen Chelikani
  • Deborah M Herbstman
  • J Chandrashekar
  • H Matsunami
  • S Firestein
  • N J Ryba
  • E Adler
  • L B Buck
  • L Feng
  • C S Zuker
  • M A Hoon
  • K L Mueller
  • J P Montmayeur
  • W Guo

Detail Information

Publications8

  1. ncbi T2Rs function as bitter taste receptors
    J Chandrashekar
    Howard Hughes Medical Institute and Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Cell 100:703-11. 2000
    ..Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds...
  2. ncbi The good taste of genomics
    S Firestein
    Nature 404:552-3. 2000
  3. ncbi A family of candidate taste receptors in human and mouse
    H Matsunami
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 404:601-4. 2000
    ..Another TRB gene is found on a human contig assigned to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil in humans...
  4. ncbi A plethora of taste receptors
    S C Kinnamon
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA
    Neuron 25:507-10. 2000
  5. ncbi Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting
    T Ueda
    Department of Anatomy and Neuroscience, Nagoya City University Medical School, Nagoya, Japan
    Biochem Biophys Res Commun 285:147-51. 2001
    ..The identification of nucleotide diversity and amino acid polymorphisms in human T2R receptors could help clarify individual differences in the acceptability and sensitivity to bitter compounds...
  6. ncbi Functional expression of mammalian bitter taste receptors in Caenorhabditis elegans
    C Conte
    Neuroscience, Pharma Research, F Hoffmann La Roche, Basel 4070, Switzerland
    Biochimie 88:801-6. 2006
    ..As a proof of the concept, we generated transgenic worms expressing human T2R4 or its mouse ortholog T2R8 receptors, which respond to two bitter tastants previously characterised as their ..
  7. ncbi Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults
    John E Hayes
    Department of Food Science, College of Agricultural Sciences, The Pennsylvania State University, 220 Food Science Building, University Park, PA 16802, USA
    Chem Senses 36:311-9. 2011
    ..A haploblock across TAS2R3, TAS2R4, and TAS2R5 explained some variability in the bitterness of espresso coffee...
  8. ncbi Functional bitter taste receptors are expressed in brain cells
    Nisha Singh
    Department of Oral Biology, University of Manitoba, Winnipeg, MB, Canada R3E 0W2
    Biochem Biophys Res Commun 406:146-51. 2011
    ..RT-PCR analysis revealed the presence of T2R4, T2R107 and T2R38 transcripts in the brain stem, cerebellum, cortex and nucleus accumbens...