TAS2R38

Summary

Gene Symbol: TAS2R38
Description: taste 2 receptor member 38
Alias: PTC, T2R38, T2R61, taste receptor type 2 member 38, PTC bitter taste receptor, taste receptor type 2 member 61, taste receptor, type 2, member 38
Species: human
Products:     TAS2R38

Top Publications

  1. Reed D, Zhu G, Breslin P, Duke F, Henders A, Campbell M, et al. The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. Hum Mol Genet. 2010;19:4278-85 pubmed publisher
    ..For PROP, the peak association was within TAS2R38 (rs713598, A49P, P = 1.6 × 10(-104)), which accounted for 45.9% of the trait variance...
  2. Kim U, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science. 2003;299:1221-5 pubmed
    The ability to taste the substance phenylthiocarbamide (PTC) has been widely used for genetic and anthropological studies, but genetic studies have produced conflicting results and demonstrated complex inheritance for this trait...
  3. Drayna D, Coon H, Kim U, Elsner T, Cromer K, Otterud B, et al. Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum Genet. 2003;112:567-72 pubmed
    The ability to taste phenylthiocarbamide (PTC) shows complex inheritance in humans...
  4. Wooding S, Kim U, Bamshad M, Larsen J, Jorde L, Drayna D. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am J Hum Genet. 2004;74:637-46 pubmed
    The ability to taste phenylthiocarbamide (PTC) is a classic phenotype that has long been known to vary in human populations...
  5. Kim U, Drayna D. Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clin Genet. 2005;67:275-80 pubmed
    The ability or inability to taste the compound phenylthiocarbamide (PTC) is a classic inherited trait in humans and has been the subject of genetic and anthropological studies for over 70 years...
  6. Timpson N, Heron J, Day I, Ring S, Bartoshuk L, Horwood J, et al. Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children. BMC Genet. 2007;8:51 pubmed
    ..Our aim was to examine the relationships between bitter tasting ability and variation at the TAS2R38 locus and to assess the role of psychosocial factors in explaining residual, within group, variation in tasting ..
  7. Keller K, Reid A, MacDougall M, Cassano H, Song J, Deng L, et al. Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children. Obesity (Silver Spring). 2010;18:1194-200 pubmed publisher
    ..between PROP status and sex on BMI z-score, and (ii) to determine if sex also interacts with variations in TAS2R38 (phenylthiocarbamide (PTC) genotype) to influence weight status in 4-6 year olds...
  8. Dotson C, Shaw H, Mitchell B, Munger S, Steinle N. Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women. Appetite. 2010;54:93-9 pubmed publisher
    ..The principal genetic determinants of phenotypic variation in PROP taste sensitivity are alleles of the TAS2R38 gene, which encodes a chemosensory receptor sensitive to thiourea compounds including PROP and ..
  9. Carrai M, Steinke V, Vodicka P, Pardini B, Rahner N, Holinski Feder E, et al. Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin. PLoS ONE. 2011;6:e20464 pubmed publisher
    ..By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk ..

More Information

Publications111 found, 100 shown here

  1. Bufe B, Hofmann T, Krautwurst D, Raguse J, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. 2002;32:397-401 pubmed
    ..If the ability of TAS2R16 to detect substances with common molecular properties is typical of the bitter receptor family, it may explain how a few receptors permit the perception of numerous bitter substances...
  2. Prodi D, Drayna D, Forabosco P, Palmas M, Maestrale G, Piras D, et al. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Chem Senses. 2004;29:697-702 pubmed
    ..This region contains the TAS2R38 gene that encodes a member of the TAS2R bitter taste receptor family...
  3. Timpson N, Christensen M, Lawlor D, Gaunt T, Day I, Ebrahim S, et al. TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. Am J Clin Nutr. 2005;81:1005-11 pubmed
    ..Recent observations have implicated 2 common haplotypes of TAS2R38 in the determination of bitter compound-tasting ability...
  4. Cannon D, Baker T, Piper M, Scholand M, Lawrence D, Drayna D, et al. Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking. Nicotine Tob Res. 2005;7:853-8 pubmed
    Phenotypic evidence indicates that the ability to taste the bitter compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) may protect against cigarette smoking...
  5. Sandell M, Breslin P. Variability in a taste-receptor gene determines whether we taste toxins in food. Curr Biol. 2006;16:R792-4 pubmed
  6. Hayes J, Bartoshuk L, Kidd J, Duffy V. Supertasting and PROP bitterness depends on more than the TAS2R38 gene. Chem Senses. 2008;33:255-65 pubmed publisher
    Polymorphisms in the TAS2R38 gene provide insight to phenotypes long associated 6-n-propylthiouracil (PROP) and phenylthiocarbamide bitterness...
  7. Mangold J, Payne T, Ma J, Chen G, Li M. Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. J Med Genet. 2008;45:578-82 pubmed publisher
    ..To determine whether single nucleotide polymorphisms (SNPs) in TAS2R16 and TAS2R38 are associated with ND and if the effects differ by sex and ethnicity...
  8. Tepper B, Koelliker Y, Zhao L, Ullrich N, Lanzara C, d Adamo P, et al. Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. Obesity (Silver Spring). 2008;16:2289-95 pubmed publisher
    Variation in the bitter-taste receptor gene, TAS2R38 confers the ability to taste 6-n-propylthiouracil (PROP)...
  9. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses. 2010;35:157-70 pubmed publisher
    ..Our data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs. ..
  10. Lee R, Xiong G, Kofonow J, Chen B, Lysenko A, Jiang P, et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest. 2012;122:4145-59 pubmed publisher
    ..Moreover, common polymorphisms of the TAS2R38 gene were linked to significant differences in the ability of upper respiratory cells to clear and kill bacteria...
  11. Mennella J, Pepino M, Reed D. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics. 2005;115:e216-22 pubmed
    ..The present study tests the hypothesis that genetic variations in the newly discovered TAS2R38 taste gene as well as cultural differences are associated with differences in sensitivity to the bitter taste of ..
  12. Wang J, Hinrichs A, Bertelsen S, Stock H, Budde J, Dick D, et al. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. Alcohol Clin Exp Res. 2007;31:209-15 pubmed
    ..genetic transmittance of taste perception have previously demonstrated a correlation between genetic variation in TAS2R38 and sensitivity to bitter-taste compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP)...
  13. Calo C, Padiglia A, Zonza A, Corrias L, Contu P, Tepper B, et al. Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype. Physiol Behav. 2011;104:1065-71 pubmed publisher
    ..This variation is associated with polymorphisms in the bitter receptor gene TAS2R38 and the taste-bud trophic factor gustin gene...
  14. Campbell M, Ranciaro A, Froment A, Hirbo J, Omar S, Bodo J, et al. Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa. Mol Biol Evol. 2012;29:1141-53 pubmed publisher
    ..genetic basis and evolutionary history of bitter taste sensitivity, we sequenced a 2,975 bp region encompassing TAS2R38, a bitter taste receptor gene, in 611 Africans from 57 populations in West Central and East Africa with diverse ..
  15. Aslani F, Sebastian T, Keidel M, Fröhlich S, Elsässer H, Schuppe H, et al. Resistance to apoptosis and autophagy leads to enhanced survival in Sertoli cells. Mol Hum Reprod. 2017;23:370-380 pubmed publisher
    ..Primary rat peritubular cells (PTC) and immortalized rat 93RS2 SC were used as controls...
  16. Aslani F, Schuppe H, Guazzone V, Bhushan S, Wahle E, Lochnit G, et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. Hum Reprod. 2015;30:417-31 pubmed publisher
    ..on rat testicular cross sections with antibodies against testicular macrophages (TM), peritubular cells (PTC) and Sertoli cells (SC)...
  17. Triggiani V, Guastamacchia E, Renzulli G, Giagulli V, Tafaro E, Licchelli B, et al. Papillary thyroid carcinoma in Peutz-Jeghers syndrome. Thyroid. 2011;21:1273-7 pubmed publisher
    ..Its occurrence with differentiated thyroid cancer, particularly papillary thyroid carcinoma (PTC), even if rare, has been described...
  18. Lee J, Seol M, Jeong S, Lee C, Ku C, Kang S, et al. A metabolic phenotype based on mitochondrial ribosomal protein expression as a predictor of lymph node metastasis in papillary thyroid carcinoma. Medicine (Baltimore). 2015;94:e380 pubmed publisher
    ..Cross-sectional observational study was conducted to classify papillary thyroid cancer (PTC) by the expression of MRP L44 (MRPL44) messenger RNA (mRNA), and to investigate the clinicopathological features...
  19. Huang C, Jap T. A systematic review of genetic studies of thyroid disorders in Taiwan. J Chin Med Assoc. 2015;78:145-53 pubmed publisher
    ..between miR146b and the BRAF mutation, which was associated with poor prognosis of papillary thyroid carcinoma (PTC). Susceptibility to Graves' disease (GD) was linked to the human leukocyte antigen (HLA) region...
  20. Shen X, Cheng S, Peng Y, Song H, Li H. Attenuation of early liver fibrosis by herbal compound "Diwu Yanggan" through modulating the balance between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition. BMC Complement Altern Med. 2014;14:418 pubmed publisher
    ..and Western blot analysis demonstrated that after DWYG treatment the expressions of Hh ligand Shh, receptor Smo and Ptc, and transcription factor Gli1 in CCl4-induced fibrotic liver tissues were dramatically repressed...
  21. Sarasin A, Bounacer A, Lepage F, Schlumberger M, Suarez H. Mechanisms of mutagenesis in mammalian cells. Application to human thyroid tumours. C R Acad Sci III. 1999;322:143-9 pubmed
    ..out that the presence has been observed, in a vast majority of radiation-induced papillary thyroid carcinomas (PTC), of an activated ret proto-oncogene originated by the fusion of the tyrosine kinase 3' domain of this gene with ..
  22. Thompson L, Herrera H, Lau S. Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations. Head Neck Pathol. 2017;11:175-185 pubmed publisher
    ..A cancer diagnosis [all papillary thyroid carcinoma (PTC)] was made after the Sistrunk procedure (SP), with a Bethesda Category V or VI classification preoperatively by ..
  23. Wang C, Saar V, Leung K, Chen L, Wong G. Human amyloid ? peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Neurobiol Dis. 2018;109:88-101 pubmed publisher
    ..elegans to the top 60 genes related to human AD confirmed an overlap of 8 genes: patched homolog 1, PTCH1 (ptc-3), the Rab GTPase activating protein, TBC1D16 (tbc-16), the WD repeat and FYVE domain-containing protein 3, WDFY3 (..
  24. Buryk M, Picarsic J, Creary S, Shaw P, Simons J, Deutsch M, et al. Identification of Unique, Heterozygous Germline Mutation, STK11 (p.F354L), in a Child with an Encapsulated Follicular Variant of Papillary Thyroid Carcinoma within Six Months of Completing Treatment for Neuroblastoma. Pediatr Dev Pathol. 2015;18:318-23 pubmed publisher
    Papillary thyroid carcinoma (PTC) is rare in children, although it is a known secondary malignancy after treatment for neuroblastoma (NB). The interval between NB treatment completion and PTC is usually more than 5 years...
  25. Kato M, Ninomiya H, Maeda M, Tanaka N, Ilmiawati C, Yoshinaga M. Commentary to Gorelenkova Miller and Mieyal (2015): sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases. Arch Toxicol. 2016;90:1017-8 pubmed publisher
    ..Since C376 of Ret-PTC-1 or its equivalent is most highly conserved and crucial for activity in PTKs, the cysteine could be one of major ..
  26. Song J, Taylor S, Trites J, Rigby M, Bullock M, Merrimen J, et al. Tumor-to-tumor metastases: papillary thyroid carcinoma into a clear cell renal cell carcinoma. J Otolaryngol Head Neck Surg. 2017;46:17 pubmed publisher
    ..This finding established a diagnosis of a tumor-to-tumor metastasis of PTC to CCRCC. Subsequent ultrasound and CT of the head and neck revealed a heterogeneously hypodense 3...
  27. Miller J, Chan C, Pearce D. The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013;22:2723-34 pubmed publisher
    ..We contend that NMD targets PTCs in NCL gene transcripts for degradation. A number of PTC mutations in CLN1, CLN2 and CLN3 lead to a significant decrease in mRNA transcripts and a corresponding decrease in ..
  28. Wilson D, Leventigiannis G, Barr C, Morgan J. ECG predictors of T wave oversensing in subcutaneous implantable cardioverter defibrillators. Int J Cardiol. 2016;220:27-31 pubmed publisher
    ..7±28.7 vs. 105.9±24.6, P=0.007), time to peak T wave (corrected for heart rate, pTc) (403.9±22.6 vs. 347.8±41.4, P=0.006), QTc interval (500.4±41.2 vs. 446.8±49.7, P=0.021), and R:T ratio (3.5±1...
  29. Kim M, Lee J, Lee S, Choi J, Kim T, Ban E, et al. Transaxillary robotic modified radical neck dissection: a 5-year assessment of operative and oncologic outcomes. Surg Endosc. 2017;31:1599-1606 pubmed publisher
    ..approach has been reported to be a safe and meticulous technique in patients with papillary thyroid carcinoma (PTC) and lateral neck node metastasis (N1b)...
  30. Yu D, Jiang Q, Xu Y, Xia W. The shelf life extension of refrigerated grass carp (Ctenopharyngodon idellus) fillets by chitosan coating combined with glycerol monolaurate. Int J Biol Macromol. 2017;101:448-454 pubmed publisher
    ..value, K value, and shear force), microbiological (total viable counts (TVC), psychrophilic bacteria counts (PTC), Pseudomonads and H2S-producing bacteria) and sensorial characteristics...
  31. Ko Y, Hwang T, Kim J, Choi Y, Lee S, Han H, et al. Diagnostic Limitation of Fine-Needle Aspiration (FNA) on Indeterminate Thyroid Nodules Can Be Partially Overcome by Preoperative Molecular Analysis: Assessment of RET/PTC1 Rearrangement in BRAF and RAS Wild-Type Routine Air-Dried FNA Specimens. Int J Mol Sci. 2017;18: pubmed publisher
    ..The results of RET/PTC1 rearrangement in 10 FNA and paired FFPE papillary thyroid carcinoma (PTC) specimens showed complete correlation. Twenty-nine (38...
  32. Zhang S, Zhang L, Feng X, Yang H. Incidence and risk factors for postoperative shoulder imbalance in scoliosis: a systematic review and meta-analysis. Eur Spine J. 2018;27:358-369 pubmed publisher
    ..RSH ≥20 mm as the criterion of PSI, our results showed that Risser sign, postoperative RSH, correction rate of PTC at follow-up, and LC at follow-up were contributing to PSI...
  33. Sharma K. Comparing sensory experience in bitter taste perception of phenylthiocarbamide within and between human twins and singletons: intrapair differences in thresholds and genetic variance estimates. Anthropol Anz. 2008;66:211-24 pubmed
    Quantitative genetic studies revealed that not all of the phenotypic variance in PTC taste perception is heritable...
  34. Kim S, Lee J, Woo J, Park I, Choe J, Kim J, et al. BRAF V600E mutation: Differential impact on central lymph node metastasis by tumor size in papillary thyroid carcinoma. Head Neck. 2016;38 Suppl 1:E1203-9 pubmed publisher
    ..of prophylactic central neck dissection is one of debating issues in the treatment of papillary thyroid carcinoma (PTC). In a previous study, the predictive value of BRAF mutation for lymph node metastasis was only significant in 0...
  35. Kim S, Woo J, Lee J, Park I, Choe J, Kim J, et al. Prophylactic Central Neck Dissection Might Not Be Necessary in Papillary Thyroid Carcinoma: Analysis of 11,569 Cases from a Single Institution. J Am Coll Surg. 2016;222:853-64 pubmed publisher
    ..central neck dissection (pCND) remain controversial in clinically node-negative (cN0) papillary thyroid carcinoma (PTC). The purpose of this study was to investigate the clinical impact of pCND with a large group of cN0 PTC patients...
  36. Ito Y, Hirokawa M, Miyauchi A, Higashiyama T, Kihara M, Miya A. Prognostic Significance of the Proportion of Tall Cell Components in Papillary Thyroid Carcinoma. World J Surg. 2017;41:742-747 pubmed publisher
    Tall cell variant (TCV) of papillary thyroid carcinoma (PTC) shows a poorer prognosis than conventional PTC. The World Health Organization (WHO) classification defines TCV as the tall cell component (TCC) in ≥50% of PTC lesions...
  37. Elwir S, Thompson J, Amateau S, Trikudanathan G, Attam R, Hassan M, et al. Endoscopic Management of Biliary Leaks and Strictures After Living Donor Liver Transplantation: Optimizing Techniques for Successful Management. Dig Dis Sci. 2017;62:244-252 pubmed publisher
    ..Advanced endoscopic techniques obviate the need for PTC and/or surgery and allow successful management in almost all LDLT recipients presenting with BC and in patients ..
  38. Yamamoto T, Takabatake Y, Takahashi A, Kimura T, Namba T, Matsuda J, et al. High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney. J Am Soc Nephrol. 2017;28:1534-1551 pubmed publisher
    ..In mice with induced PTC-specific ablation of autophagy, PTCs of HFD-mice exhibited greater accumulation of ubiquitin-positive protein ..
  39. Chen Q, Wei T, Wang X, Li Z, Du Z, Zhu J. The total number of prelaryngeal and pretracheal lymph node metastases: is it a reliable predictor of contralateral central lymph node metastasis in papillary thyroid carcinoma?. J Surg Res. 2017;214:162-167 pubmed publisher
    Central lymph node (CLN) metastasis in papillary thyroid carcinoma (PTC) is common and being able to predict CLN metastasis helps surgeons determine individualized therapy...
  40. Jang J, Shim H, Kwon H, Chung H, Jung P, Kim S, et al. Improvement of outcomes in patients with pelvic fractures and hemodynamic instability after the establishment of a Korean regional trauma center. Eur J Trauma Emerg Surg. 2019;45:107-113 pubmed publisher
    ..Patients were divided into two groups: the pre-trauma center (PTC) group (n = 23) and trauma center (TC) group (n = 27). Sixteen (32.0%) patients died of exsanguination...
  41. Tam A, Ozdemir D, Aydin C, Bestepe N, Ulusoy S, Sungu N, et al. Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer. Endocrine. 2018;59:565-572 pubmed publisher
    ..serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC)...
  42. Zou M, Baitei E, Al Rijjal R, Parhar R, Al Mohanna F, Kimura S, et al. KRAS(G12D)-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1. Lab Invest. 2015;95:1269-77 pubmed publisher
    ..Differential SPRY1 expression was demonstrated: increased in FTC and reduced in papillary thyroid cancer (PTC)...
  43. Yoon M, Jung S, Kim T, Ha T, Urm S, Park J, et al. Relationships between transporter expression and the status of BRAF V600E mutation and F-18 FDG uptake in papillary thyroid carcinomas. Endocr Res. 2016;41:64-9 pubmed publisher
    ..We retrospectively analyzed data of 52 PTC patients (41 women and 11 men; mean age, 52.4 ± 14.5 years)...
  44. Rusinek D, Swierniak M, Chmielik E, Kowal M, Kowalska M, Cyplinska R, et al. BRAFV600E-Associated Gene Expression Profile: Early Changes in the Transcriptome, Based on a Transgenic Mouse Model of Papillary Thyroid Carcinoma. PLoS ONE. 2015;10:e0143688 pubmed publisher
    The molecular mechanisms driving the papillary thyroid carcinoma (PTC) are still poorly understood...
  45. Chigerwe M, Heller M, Balcomb C, Angelos J. Use of a percutaneous transabdominal catheter for management of obstructive urolithiasis in goats, sheep, and potbellied pigs: 69 cases (2000-2014). J Am Vet Med Assoc. 2016;248:1287-90 pubmed publisher
    OBJECTIVE To evaluate the use of a percutaneous transabdominal catheter (PTC) for urinary bladder drainage in goats, sheep, and potbellied pigs with obstructive urolithiasis. DESIGN Retrospective case series...
  46. Rabiee S, Nadoushan M, Rayeni N, Ansari I. Correlation between human epidermal growth factor receptor 2 oncoprotein expression and some prognostic factors in papillary thyroid carcinoma. Indian J Pathol Microbiol. 2017;60:324-327 pubmed publisher
    Thyroid cancer is one of the increasing cancer diagnoses in the United States. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer...
  47. An H, Ko G, Lee J, Lee J, Kim D, Yang J, et al. Programmed Death-Ligand 1 Expression and Its Correlation with Lymph Node Metastasis in Papillary Thyroid Carcinoma. J Pathol Transl Med. 2017;: pubmed publisher
    ..However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited...
  48. Rossi E, Martini M, Bizzarro T, Capodimonti S, Cenci T, Lombardi C, et al. Uncommon BRAF mutations in the follicular variant of thyroid papillary carcinoma: New insights. Cancer Cytopathol. 2015;123:593-602 pubmed publisher
    ..antibody (VE1) immunocytochemical and molecular findings of BRAF mutations in PTCs and in the follicular variant of PTC (FVPC)...
  49. Ji Y, Yoo H, Song C, Park C, Lee C, Tae K. Predictive factors and pattern of central lymph node metastasis in unilateral papillary thyroid carcinoma. Auris Nasus Larynx. 2016;43:79-83 pubmed publisher
    Prophylactic central neck dissection (CND) for papillary thyroid carcinoma (PTC) remains controversial...
  50. Lee Y, Eun Y, Chung J, Kim S, Chon S, Oh S, et al. Single Nucleotide Polymorphism of Interleukin-18 and Interleukin-18 Receptor and the Risk of Papillary Thyroid Cancer. Exp Clin Endocrinol Diabetes. 2015;123:598-603 pubmed publisher
    ..polymorphisms are associated with the development and clinicopathological features of papillary thyroid carcinoma (PTC)...
  51. Yoon S, An Y, Lee S, So E, Kim J, Chung Y, et al. Relation Between F-18 FDG Uptake of PET/CT and BRAFV600E Mutation in Papillary Thyroid Cancer. Medicine (Baltimore). 2015;94:e2063 pubmed publisher
    ..mutation and F-18 fluorodeoxyglucose (FDG) uptake are potential prognostic factors of papillary thyroid cancer (PTC)...
  52. Basar M, Ahmad M, Cho J, Ibrahim F. Performance evaluation of power transmission coils for powering endoscopic wireless capsules. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:2263-6 pubmed publisher
    ..We validated our analysis by comparing the computed data with data measured from a fabricated Helmholtz PTC. This analysis disclosed that at the same excitation power, all the PTCs are able to transfer same amount of ..
  53. Hsu Y, Liu C, Yang P, Tsai C, Lee J, Cheng S. Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer. World J Surg. 2016;40:2922-2929 pubmed publisher
    Age is an important prognostic factor for papillary thyroid cancer (PTC). However, little is known about why advanced age is associated with poor prognosis. The study investigated the changes in transcriptional profiling related to age...
  54. Behringer M, Hall D. Selection on Position of Nonsense Codons in Introns. Genetics. 2016;204:1239-1248 pubmed publisher
    ..pathway degrades aberrant mRNAs, which it recognizes by the presence of an in-frame premature termination codon (PTC). We investigated whether selection has shaped the location of PTCs in introns to reduce waste and facilitate NMD...
  55. Pyo J, Sohn J, Kang G. Diagnostic assessment of intraoperative cytology for papillary thyroid carcinoma: using a decision tree analysis. J Endocrinol Invest. 2017;40:305-311 pubmed publisher
    ..characteristics and the diagnostic usefulness of intraoperative cytology (IOC) for papillary thyroid carcinoma (PTC). In addition, using decision tree analysis, effective features for accurate cytological diagnosis were sought...
  56. Al Homsi A, Goodyke A, McLane M, Abdel Mageed S, Cole K, Muilenburg M, et al. Post-Transplantation Cyclophosphamide and Ixazomib Combination Rescues Mice Subjected to Experimental Graft-versus-Host Disease and Is Superior to Either Agent Alone. Biol Blood Marrow Transplant. 2017;23:255-261 pubmed publisher
    ..Such approaches include, among others, the use of post-transplantation cyclophosphamide (PTC) and proteasome inhibitors...
  57. Welch W, Tojo A, Wilcox C. Roles of NO and oxygen radicals in tubuloglomerular feedback in SHR. Am J Physiol Renal Physiol. 2000;278:F769-76 pubmed
    ..Microperfusion of tempol (10(-4) M) into the efferent arteriole (EA) supplying the peritubular capillaries (PTC) blunted TGF. The response to tempol was significantly (P< 0...
  58. Zhao S, Wang Q, Li Z, Ma X, Wu L, Ji H, et al. LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-κB activation in papillary thyroid carcinoma. J Exp Clin Cancer Res. 2015;34:146 pubmed publisher
    ..increased over the past few decades, and the most frequent types of this cancer are papillary thyroid carcinoma (PTC) and small primary tumors. In PTC, oncogene activation is known to occur at a high frequency...
  59. Caleo A, Landolfi L, Vitale M, Di Crescenzo V, Vatrella A, De Rosa G, et al. The diagnostic accuracy of fine-needle cytology of Hurthle cell lesions; A comprehensive cytological, clinical and ultrasonographic experience. Int J Surg. 2016;28 Suppl 1:S65-9 pubmed publisher
    ..Two cases were diagnosed suspect HC papillary thyroid carcinoma (PTC) and classified THY4 and 2 cases were diagnosed HC-PTC and classified THY5...
  60. Sullivan M, Graham P, Alexander E, Ruan D, Nehs M, Gawande A, et al. Prevalence of Contralateral Tumors in Patients with Follicular Variant of Papillary Thyroid Cancer. J Am Coll Surg. 2017;224:1021-1027 pubmed publisher
    ..5%) and included fvPTC (n = 40), classical PTC (n = 22), tall cell PTC (n = 2), and follicular carcinoma (n = 1)...
  61. Zhang D, Liu X, Wei B, Qiao G, Jiang T, Chen Z. Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. Int J Endocrinol. 2017;2017:2645904 pubmed publisher
    ..lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown...
  62. Viola D, Giani C, Mazzeo S, Ugolini C, Ciampi R, Molinaro E, et al. KIF5B/RET Rearrangement in a Carcinoma of the Thyroid Gland: A Case Report of a Fatal Disease. J Clin Endocrinol Metab. 2017;102:3091-3096 pubmed publisher
    The diffuse sclerosing variant of papillary thyroid cancer (DSV-PTC) is a rare variant of papillary thyroid cancer (PTC) with different clinicopathological features compared with conventional PTC...
  63. Kim Y, Kim M, Jeon S, Kim J, Kim C, Bae J, et al. Prognostic implication of histological features associated with EHD2 expression in papillary thyroid carcinoma. PLoS ONE. 2017;12:e0174737 pubmed publisher
    Papillary thyroid carcinoma (PTC) is a heterogeneous tumor with various histological and molecular subtypes. EHD2 is involved in endocytosis and endosomal recycling...
  64. Inoue H, Yamakawa Kobayashi K, Suzuki Y, Nakano T, Hayashi H, Kuwano T. A case study on the association of variation of bitter-taste receptor gene TAS2R38 with the height, weight and energy intake in Japanese female college students. J Nutr Sci Vitaminol (Tokyo). 2013;59:16-21 pubmed
    ..Variation of one bitter taste receptor gene, TAS2R38, which is associated with the differential sensitivity to phenylthiocarbamide (PTC) and 6-n-propylthiouracil (..
  65. Latorre R, Huynh J, Mazzoni M, Gupta A, Bonora E, Clavenzani P, et al. Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects. PLoS ONE. 2016;11:e0147468 pubmed publisher
    ..The aims of this study were to test whether T2R38 expression is altered in overweight/obese (OW/OB) compared to normal weight (NW) subjects and characterize the ..
  66. Wang J, Ma J, Liu Q, Hu Y, Dong Y. Cd(ii)-MOF-IM: post-synthesis functionalization of a Cd(ii)-MOF as a triphase transfer catalyst. Chem Commun (Camb). 2016;52:6989-92 pubmed publisher
    ..Moreover, they can be easily recovered and reused under the PTC conditions...
  67. Liang Y, Zuo T. Papillary Thyroid Carcinoma Cervical Lymph Node Metastasis with Cystic Change Differentiated from Congenital Cystic Lesions with the Assistance of Immunohistochemistry: A Case Study. Head Neck Pathol. 2017;11:301-305 pubmed publisher
    Diagnosis of cystic papillary thyroid carcinoma (PTC) lymph node metastasis at head neck region can be a challenge in the absence of known PTC history...
  68. Carrai M, Campa D, Vodicka P, Flamini R, Martelli I, Slyskova J, et al. Association between taste receptor (TAS) genes and the perception of wine characteristics. Sci Rep. 2017;7:9239 pubmed publisher
    ..We observed several interesting associations, among which the association between several TAS2R38 gene single nucleotide polymorphisms (P = 0...
  69. Neu Yilik G, Raimondeau E, Eliseev B, Yeramala L, Amthor B, Deniaud A, et al. Dual function of UPF3B in early and late translation termination. EMBO J. 2017;36:2968-2986 pubmed publisher
    ..unknown functions of UPF3B during the early and late phases of translation termination suggest that UPF3B is involved in the crosstalk between the NMD machinery and the PTC-bound ribosome, a central mechanistic step of RNA surveillance.
  70. Soylu S, Arikan A, Teksoz S, Ozcan M, Bukey Y. Skin metastasis on the neck: an unusual presentation of recurrence of papillary thyroid carcinoma. Gland Surg. 2017;6:594-597 pubmed publisher
    Skin metastasis of papillary thyroid carcinoma (PTC) is rare. Here, two cases of skin metastases of PTC are presented. Both of the patients were females, one is 83 and the other is 65 years old...
  71. Pogach M, Cao Y, Millien G, Ramirez M, Williams M. Key developmental regulators change during hyperoxia-induced injury and recovery in adult mouse lung. J Cell Biochem. 2007;100:1415-29 pubmed
    ..upon their known or putative roles in lung development and organogenesis: TTF-1, FGF9, FGF10, BMP4, PDGF-A, VEGF, Ptc, Shh, Sca-1, BCRP, CD45, and Cyclin-D2...
  72. Ramos Lopez O, Roman S, Martinez Lopez E, Gonzalez Aldaco K, Ojeda Granados C, Sepulveda Villegas M, et al. Association of a novel TAS2R38 haplotype with alcohol intake among Mexican-Mestizo population. Ann Hepatol. 2015;14:729-34 pubmed
    Alcohol intake has been associated with the bitter taste receptor T2R38. TAS2R38 gene expresses two common haplotypes: PAV and AVI. It has been reported that AVI homozygotes consume more alcohol than heterozygotes and PAV homozygotes...
  73. Kuba S, Yamanouchi K, Hayashida N, Maeda S, Adachi T, Sakimura C, et al. Total thyroidectomy versus thyroid lobectomy for papillary thyroid cancer: Comparative analysis after propensity score matching: A multicenter study. Int J Surg. 2017;38:143-148 pubmed publisher
    In patients with papillary thyroid carcinoma (PTC), the role of total thyroidectomy (TT) versus that of thyroid lobectomy (TL) has been controversial...
  74. Scieżyńska A, Ruszkowska E, Szulborski K, Rydz K, Wierzbowska J, Kosińska J, et al. Processing of OPA1 with a novel N-terminal mutation in patients with autosomal dominant optic atrophy: Escape from nonsense-mediated decay. PLoS ONE. 2017;12:e0183866 pubmed publisher
    ..majority of patients it is caused by OPA1 mutations and those predicted to introduce a premature termination codon (PTC) are frequently detected...
  75. Wang Y, Barnes E. Theoretical Studies of the Glycosidation of 2-O-Substituted 5-Fluorouracil: N-Regioselective Synthesis with the Phase-Transfer-Catalysis Method. J Phys Chem A. 2017;121:8866-8883 pubmed publisher
    ..observed N-regioselective glycosidation of 2-O-substituted 5-fluorouracil (5-FU) via the phase-transfer-catalysis (PTC) method was investigated computationally...
  76. Antonello Z, Hsu N, Bhasin M, Roti G, Joshi M, Van Hummelen P, et al. Vemurafenib-resistance via de novo RBM genes mutations and chromosome 5 aberrations is overcome by combined therapy with palbociclib in thyroid carcinoma with BRAFV600E. Oncotarget. 2017;8:84743-84760 pubmed publisher
    Papillary thyroid carcinoma (PTC) is the most frequent endocrine tumor. BRAFV600E represents the PTC hallmark and is targeted with selective inhibitors (e.g. vemurafenib)...
  77. Spencer J, Barclay M, Gallagher M, Winkler R, Unlu I, Wu Y, et al. Comparing postdeposition reactions of electrons and radicals with Pt nanostructures created by focused electron beam induced deposition. Beilstein J Nanotechnol. 2017;8:2410-2424 pubmed publisher
    ..the effect observed with AH, densification of the structure was observed during the postdeposition purification of PtC x deposits created from MeCpPtMe3 using atomic oxygen (AO), although the limited ..
  78. Liang Z, Xie W, Zhao M, Cheng G, Wu M. DDR2 facilitates papillary thyroid carcinoma epithelial mesenchymal transition by activating ERK2/Snail1 pathway. Oncol Lett. 2017;14:8114-8121 pubmed publisher
    ..epithelial-mesenchymal transition (EMT); however, the expression profile of DDR2 in papillary thyroid carcinoma (PTC) with local metastasis and the effect of DDR2 on PTC cells remain unknown...
  79. Shigeoka T, Kato S, Kawaichi M, Ishida Y. Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity. Nucleic Acids Res. 2012;40:6887-97 pubmed publisher
    ..Here we show that stable RNA secondary structures between a PTC and a downstream exon-exon junction increase the levels of potential NMD substrates...
  80. Moberg P, Li M, Kanes S, Gur R, Kamath V, Turetsky B. Association of schizophrenia with the phenylthiocarbamide taste receptor haplotype on chromosome 7q. Psychiatr Genet. 2012;22:286-9 pubmed publisher
    ..taste sensitivity is an inherited trait determined primarily by allelic variation of the taste-receptor gene TAS2R38 on chromosome 7q...
  81. Wölfle U, Elsholz F, Kersten A, Haarhaus B, Müller W, Schempp C. Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes. Skin Pharmacol Physiol. 2015;28:137-46 pubmed publisher
    ..Here, we show for the first time the expression of TAS2R1 and TAS2R38 in human skin...
  82. Gil S, Coldwell S, Drury J, Arroyo F, Phi T, Saadat S, et al. Genotype-specific regulation of oral innate immunity by T2R38 taste receptor. Mol Immunol. 2015;68:663-70 pubmed publisher
    The bitter taste receptor T2R38 has been shown to regulate mucosal innate immune responses in the upper airway epithelium...
  83. Adam B, Smith R, Rosales I, Matsunami M, Afzali B, Oura T, et al. Chronic Antibody-Mediated Rejection in Nonhuman Primate Renal Allografts: Validation of Human Histological and Molecular Phenotypes. Am J Transplant. 2017;17:2841-2850 pubmed publisher
    ..confirmed the association between three-gene set expression and AMR and highlighted the ambiguity of v lesions and ptc lesions between AMR and T cell-mediated rejection (TCMR)...
  84. Wu Y, Zhang Y, Sun Y, Yu J, Wang P, Ma H, et al. Up-Frameshift Protein UPF1 Regulates Neurospora crassa Circadian and Diurnal Growth Rhythms. Genetics. 2017;206:1881-1893 pubmed publisher
    ..factors play a conserved role in regulating the surveillance of NMD targets including premature termination codon (PTC)-containing transcripts and normal transcripts...
  85. Marotta V, Sciammarella C, Chiofalo M, Gambardella C, Bellevicine C, Grasso M, et al. Hashimoto's thyroiditis predicts outcome in intrathyroidal papillary thyroid cancer. Endocr Relat Cancer. 2017;24:485-493 pubmed publisher
    Hashimoto's thyroiditis (HT) seems to have favourable prognostic impact on papillary thyroid cancer (PTC), but data were obtained analysing all disease stages...
  86. Janus D, Wojcik M, Drabik G, Wyrobek Ł, Starzyk J. Ultrasound variants of autoimmune thyroiditis in children and adolescents and their clinical implication in relation to papillary thyroid carcinoma development. J Endocrinol Invest. 2018;41:371-380 pubmed publisher
    The prevalence of autoimmune thyroiditis (AIT) and papillary thyroid carcinoma (PTC) is rising in children and adolescents, and the coincidence of AIT and PTC is as high as 6.3-43%...
  87. Gerbracht J, Boehm V, Gehring N. Plasmid transfection influences the readout of nonsense-mediated mRNA decay reporter assays in human cells. Sci Rep. 2017;7:10616 pubmed publisher
    ..assesses the fidelity of transcripts and eliminates mRNAs containing a premature translation termination codon (PTC). When studying mRNA degradation pathways, reporter mRNAs are commonly expressed in cultivated cells...
  88. Li L, Wang X, Sharvan R, Gao J, Qu S. Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways. Biomed Pharmacother. 2017;95:1225-1231 pubmed publisher
    ..We therefore examined the effect of berberine on papillary thyroid carcinoma (PTC, the most common subtype) and anaplastic thyroid carcinoma (ATC, the most malignant and aggressive subtype)...
  89. Rosney D, F Noe M, J Horvath P. Powerful Tools for Caregivers, a Group Psychoeducational Skill-Building Intervention for Family Caregivers. J Caring Sci. 2017;6:187-198 pubmed publisher
    ..Powerful Tools for Caregivers (PTC) is a national program that aims to empower caregivers to better care for themselves and enhance their self-..
  90. Saporito D, Brock P, Hampel H, Sipos J, Fernandez S, Liyanarachchi S, et al. Penetrance of a rare familial mutation predisposing to papillary thyroid cancer. Fam Cancer. 2018;17:431-434 pubmed publisher
    ..33 that we observed in affected mutation carriers differs greatly from the ratio of approximately 3:1 observed in PTC, supporting a central role of the mutation...
  91. Lv T, Zhu C, Di Z. Risk factors stratifying malignancy of nodules in contralateral thyroid lobe in patients with pre-operative ultrasound indicated unilateral papillary thyroid carcinoma: A retrospective analysis from single centre. Clin Endocrinol (Oxf). 2017;: pubmed publisher
    Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma with a favourable clinical outcome...
  92. Liang J, Cai W, Feng D, Teng H, Mao F, Jiang Y, et al. Genetic landscape of papillary thyroid carcinoma in the Chinese population. J Pathol. 2017;: pubmed publisher
    ..understanding pathogenic mechanisms of this disease; while so far, the genetic landscape in Chinese patients with PTC remains uncharacterized...