Gene Symbol: TAS2R14
Description: taste 2 receptor member 14
Alias: T2R14, TRB1, taste receptor type 2 member 14, taste receptor, family B, member 1, taste receptor, type 2, member 14
Species: human
Products:     TAS2R14

Top Publications

  1. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses. 2010;35:157-70 pubmed publisher
    ..Our data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs. ..
  2. Xu Q, Singh N, Hong H, Yan X, Yu W, Jiang X, et al. Hen protein-derived peptides as the blockers of human bitter taste receptors T2R4, T2R7 and T2R14. Food Chem. 2019;283:621-627 pubmed publisher
    ..quinine- or diphenhydramine-dependent calcium mobilization of HEK293T cells expressing human T2R4, T2R7, or T2R14 (P < 0.05)...
  3. Risso D, Morini G, Pagani L, Quagliariello A, Giuliani C, De Fanti S, et al. Genetic signature of differential sensitivity to stevioside in the Italian population. Genes Nutr. 2014;9:401 pubmed publisher
    ..Recently, TAS2R4 and TAS2R14 have been identified as the receptors that mediate the bitter off-taste of steviol glycosides in vitro...
  4. Martin L, Nachtigal M, Selman T, Nguyen E, Salsman J, Dellaire G, et al. Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival. Mol Cell Biochem. 2019;454:203-214 pubmed publisher
    ..of Tas2R subtype expression in several epithelial ovarian or prostate cancer cell lines, and the functionality of Tas2R14 was determined...
  5. Zhou Y, Wang Y, Krause K, Yang T, Dongus J, Zhang Y, et al. Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis. Nat Genet. 2018;50:638-644 pubmed publisher
    ..A triple trb1-2, trb2-1, and trb3-2 (trb1/2/3) mutant with a developmental phenotype and a transcriptome strikingly similar to ..
  6. Miyajima C, Inoue Y, Hayashi H. Pseudokinase tribbles 1 (TRB1) negatively regulates tumor-suppressor activity of p53 through p53 deacetylation. Biol Pharm Bull. 2015;38:618-24 pubmed publisher
    Tribbles 1 (TRB1) is one of the mammalian orthologs of Drosophila Tribbles, which regulates development and cell proliferation. TRB1 is suggested to act as a scaffold protein in signaling pathways for important cellular processes...
  7. Nowak S, Di Pizio A, Levit A, Niv M, Meyerhof W, Behrens M. Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14. Biochim Biophys Acta Gen Subj. 2018;1862:2162-2173 pubmed publisher
    ..Among these receptors three, TAS2R10, TAS2R14 and TAS2R46, exhibit extraordinary wide agonist profiles and hence contribute disproportionally high to the ..
  8. Freund J, Mansfield C, Doghramji L, Adappa N, Palmer J, Kennedy D, et al. Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling. J Biol Chem. 2018;293:9824-9840 pubmed publisher
    ..In HEK293T cells, PQS activated T2R4, -16, and -38, whereas HHQ activated T2R14. 2,4-Dihydroxyquinolone had no effect...
  9. Mancuso G, Borgonovo G, Scaglioni L, Bassoli A. Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception. Molecules. 2015;20:18907-22 pubmed publisher
    ..Among the alkaloids, skimmianine was active as a specific agonist of T2R14, whereas kokusaginin did not activate any of the tested receptors...

More Information


  1. Zhou Y, Hartwig B, James G, Schneeberger K, Turck F. Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. Plant Cell. 2016;28:87-101 pubmed publisher
    ..Two enhancing mutations were mapped to TELOMERE REPEAT BINDING PROTEIN1 (TRB1) and its paralog TRB3...
  2. Sakai S, Miyajima C, Uchida C, Itoh Y, Hayashi H, Inoue Y. Tribbles-Related Protein Family Members as Regulators or Substrates of the Ubiquitin-Proteasome System in Cancer Development. Curr Cancer Drug Targets. 2016;16:147-56 pubmed
    ..Tribbles genes are evolutionary conserved, and three TRB genes (TRB1, TRB2 and TRB3) have been identified in mammals...
  3. Miyajima C, Itoh Y, Inoue Y, Hayashi H. Positive Regulation of Interleukin-2 Expression by a Pseudokinase, Tribbles 1, in Activated T Cells. Biol Pharm Bull. 2015;38:1126-33 pubmed publisher
    Tribbles 1 (TRB1), a member of the Tribbles family, is a pseudokinase that is conserved among species and implicated in various human diseases including leukemia, cardiovascular diseases, and metabolic disorders...
  4. Hyland P, Zhang H, Yang Q, Yang H, Hu N, Lin S, et al. Pathway, in silico and tissue-specific expression quantitative analyses of oesophageal squamous cell carcinoma genome-wide association studies data. Int J Epidemiol. 2016;45:206-20 pubmed publisher
    ..candidate pathways (and genes) for ESCC risk included taste transduction (KEGG_hsa04742; TAS2R13, TAS2R42, TAS2R14, TAS2R46,TAS2R50), long-patch base excision repair (Reactome_pid; POLD2) and the metabolics pathway (..
  5. Schrumpfová P, Vychodilová I, Hapala J, SchoÅ™ová Å, Dvořáček V, Fajkus J. Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo. Plant Mol Biol. 2016;90:189-206 pubmed publisher
    Recently we characterised TRB1, a protein from a single-myb-histone family, as a structural and functional component of telomeres in Arabidopsis thaliana...
  6. Zheng K, Lu P, Delpapa E, Bellve K, Deng R, Condon J, et al. Bitter taste receptors as targets for tocolytics in preterm labor therapy. FASEB J. 2017;31:4037-4052 pubmed publisher
    ..In human myometrial cells, knockdown of TAS2R14 but not TAS2R10 inhibits ChQ's reversal effect on an oxytocin-induced rise in [Ca2+]i ..
  7. Li C, Lin F, Li Y, Wei W, Wang H, Qin L, et al. A ?-glucosidase hyper-production Trichoderma reesei mutant reveals a potential role of cel3D in cellulase production. Microb Cell Fact. 2016;15:151 pubmed publisher
    ..The T. reesei recombinant strain TRB1 was constructed from T. reesei RUT-C30 by the T-DNA-based mutagenesis...
  8. Hernández Puga G, Mendoza A, León Del Río A, Orozco A. Jab1 is a T2-dependent coactivator or a T3-dependent corepressor of TRB1-mediated gene regulation. J Endocrinol. 2017;232:451-459 pubmed publisher
    ..looked for specific coregulators recruited by the long isoform of the teleostean thyroid hormone receptor beta 1 (L-Trb1) when bound to the bioactive TH, 3,5-T2 (T2)...
  9. Jaggupilli A, Singh N, Upadhyaya J, Sikarwar A, Arakawa M, Dakshinamurti S, et al. Analysis of the expression of human bitter taste receptors in extraoral tissues. Mol Cell Biochem. 2017;426:137-147 pubmed publisher
    ..pattern of TAS2R expression with TAS2R3, 4, 5, 10, 13, 19, and 50 transcripts expressed at moderate levels and TAS2R14 and TAS2R20 (or TASR49) at high levels in the various tissues analyzed...
  10. Oliver V, van Bysterveldt K, Cadzow M, Steger B, Romano V, Markie D, et al. A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions. Ophthalmology. 2016;123:709-22 pubmed publisher
    ..Two variants segregated in 06NZ-TRB1 with ERED: COL17A1 c.3156C→T and DNAJC9 c.334G→A. The COL17A1 c...
  11. Hariri B, McMahon D, Chen B, Freund J, Mansfield C, Doghramji L, et al. Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor. J Biol Chem. 2017;292:8484-8497 pubmed publisher
    ..We also demonstrate that sinonasal ciliated epithelial cells express T2R14, which closely co-localizes (<7 nm) with the T2R38 isoform...
  12. Roland W, Vincken J, Gouka R, Van Buren L, Gruppen H, Smit G. Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. J Agric Food Chem. 2011;59:11764-71 pubmed publisher
    ..Furthermore, the bioactive isoflavonoids equol and coumestrol activated both receptors, indicating that their sensory impact should be considered when used as food ingredients. ..
  13. Campa D, Vodicka P, Pardini B, Naccarati A, Carrai M, Vodickova L, et al. A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer. BMC Med Genet. 2010;11:88 pubmed publisher
    ..b>TAS2R14 is one of the better characterized members of the taste receptor family and has several polymorphic variants...
  14. Zhang Y, Wang X, Li X, Peng S, Wang S, Huang C, et al. Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies. Sci Rep. 2017;7:12174 pubmed publisher
    ..The aim of this study was to identify natural direct TAS2R14 agonists from Radix Bupleuri that can inhibit mast cell degranulation...
  15. Kim D, Pauer S, Yong H, An S, Liggett S. ?2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function. J Biol Chem. 2016;291:17616-28 pubmed publisher
    ..We find, however, that co-expression of ?2-adrenergic receptors (?2AR) in HEK-293T routes TAS2R14 to the cell surface by forming receptor heterodimers...
  16. Chandrashekar J, Mueller K, Hoon M, Adler E, Feng L, Guo W, et al. T2Rs function as bitter taste receptors. Cell. 2000;100:703-11 pubmed
    ..Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds. ..
  17. Kim D, Woo J, Geffken E, An S, Liggett S. Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G?i1,2,3. Am J Respir Cell Mol Biol. 2017;56:762-771 pubmed publisher
    ..experiments in human embryonic kidney-293T cells, we confirmed an agonist-dependent physical interaction between TAS2R14 and G?i2...
  18. Karaman R, Nowak S, Di Pizio A, Kitaneh H, Abu Jaish A, Meyerhof W, et al. Probing the Binding Pocket of the Broadly Tuned Human Bitter Taste Receptor TAS2R14 by Chemical Modification of Cognate Agonists. Chem Biol Drug Des. 2016;88:66-75 pubmed publisher
    ..One of the most broadly tuned human bitter taste receptors is the TAS2R14 recognizing an enormous variety of chemically diverse synthetic and natural bitter compounds, including numerous ..
  19. Le Nevé B, Foltz M, Daniel H, Gouka R. The steroid glycoside H.g.-12 from Hoodia gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu-80 cells. Am J Physiol Gastrointest Liver Physiol. 2010;299:G1368-75 pubmed publisher
    ..g.-12 could activate human bitter receptors. The steroid glycoside activated selectively TAS2R7 and TAS2R14, both heterologously expressed in HEK 293 cells...
  20. Matsunami H, Montmayeur J, Buck L. A family of candidate taste receptors in human and mouse. Nature. 2000;404:601-4 pubmed
    ..Another TRB gene is found on a human contig assigned to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil in humans. ..
  21. Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W. Members of RTP and REEP gene families influence functional bitter taste receptor expression. J Biol Chem. 2006;281:20650-9 pubmed
    ..Finally, expression analyses demonstrate RTP and REEP gene expression in human circumvallate papillae and testis, both of which are sites of TAS2R gene expression. ..
  22. Kinnamon S. A plethora of taste receptors. Neuron. 2000;25:507-10 pubmed