TAS2R1

Summary

Gene Symbol: TAS2R1
Description: taste 2 receptor member 1
Alias: T2R1, TRB7, taste receptor type 2 member 1, taste receptor, family B, member 7, taste receptor, type 2, member 1
Species: human
Products:     TAS2R1

Top Publications

  1. Weiss L, Arking D, Daly M, Chakravarti A. A genome-wide linkage and association scan reveals novel loci for autism. Nature. 2009;461:802-8 pubmed publisher
    ..however, genotyping of top hits in additional families revealed an SNP on chromosome 5p15 (between SEMA5A and TAS2R1) that was significantly associated with autism (P = 2 x 10(-7))...
  2. Dai W, You Z, Zhou H, Zhang J, Hu Y. Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies. J Recept Signal Transduct Res. 2011;31:229-40 pubmed publisher
    ..This indicates that the control switch we proposed may be universal in T2Rs. Besides, our results also suggest that the formation of a short helical segment in ICL2 may be necessary for the activation of hTAS2R1. ..
  3. Yoshida Y, Wang Z, Tehrani K, Pendleton E, Tanaka R, Mortensen L, et al. Bitter taste receptor T2R7 and umami taste receptor subunit T1R1 are expressed highly in Vimentin-negative taste bud cells in chickens. Biochem Biophys Res Commun. 2019;: pubmed publisher
    ..In the chicken genome, bitter (T2R1, T2R2, and T2R7) and umami (T1R1 and T1R3) taste receptor genes have been found...
  4. Hirose N, Kawabata Y, Kawabata F, Nishimura S, Tabata S. Bitter taste receptor T2R1 activities were compatible with behavioral sensitivity to bitterness in chickens. Biochem Biophys Res Commun. 2015;460:464-8 pubmed publisher
    ..We cloned one of the bitter taste receptors, T2R1, from the chicken palate, constructed several biosensor-cells expressing chicken T2R1 (cT2R1), and determined a ..
  5. Tsutsui K, Otoh M, Sakurai K, Suzuki Hashido N, Hayakawa T, Misaka T, et al. Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys. BMC Evol Biol. 2016;16:208 pubmed
    ..We found that TAS2R1 and TAS2R4 orthologs differ in sensitivity among the NWM species for colchicine and camphor, respectively...
  6. Dey B, Kawabata F, Kawabata Y, Yoshida Y, Nishimura S, Tabata S. Identification of functional bitter taste receptors and their antagonist in chickens. Biochem Biophys Res Commun. 2017;482:693-699 pubmed publisher
    ..There are three putative chicken bitter taste receptors, chicken T2R1 (cT2R1), cT2R2 and cT2R7, which were identified using genome information and cell-based assays...
  7. Su Y, Li D, Gaur U, Wang Y, Wu N, Chen B, et al. Genetic diversity of bitter taste receptor gene family in Sichuan domestic and Tibetan chicken populations. J Genet. 2016;95:675-81 pubmed
    ..Previous research had revealed that chicken has only three bitter taste receptor genes (Tas2r1, Tas2r2 and Tas2r7)...
  8. Khor S, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, et al. Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. Peerj. 2013;1:e66 pubmed publisher
    ..This is the first GWAS of HLA-DQB1*06:02 negative EHS, and the identification of these three new susceptibility loci should provide additional insights to the pathophysiological pathway of this condition. ..
  9. Wölfle U, Elsholz F, Kersten A, Haarhaus B, Müller W, Schempp C. Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes. Skin Pharmacol Physiol. 2015;28:137-46 pubmed publisher
    ..Here, we show for the first time the expression of TAS2R1 and TAS2R38 in human skin...

More Information

Publications20

  1. An S, Wang W, Koziol White C, Ahn K, Lee D, Kurten R, et al. TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. Am J Physiol Lung Cell Mol Physiol. 2012;303:L304-11 pubmed publisher
    ..These findings portend a favorable therapeutic profile for TAS2R agonists for the treatment of bronchospasm in asthma or chronic obstructive lung disease. ..
  2. Upadhyaya J, Pydi S, Singh N, Aluko R, Chelikani P. Bitter taste receptor T2R1 is activated by dipeptides and tripeptides. Biochem Biophys Res Commun. 2010;398:331-5 pubmed publisher
    ..this study, we tested the ability of the bitter tasting tri- and di-peptides to activate the human bitter receptor, T2R1. In addition, we tested the ability of peptide inhibitors of the blood pressure regulatory protein, angiotensin ..
  3. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses. 2010;35:157-70 pubmed publisher
    ..Our data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs. ..
  4. Kinnamon S. A plethora of taste receptors. Neuron. 2000;25:507-10 pubmed
  5. Chandrashekar J, Mueller K, Hoon M, Adler E, Feng L, Guo W, et al. T2Rs function as bitter taste receptors. Cell. 2000;100:703-11 pubmed
    ..Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds. ..
  6. Sharma P, Panebra A, Pera T, Tiegs B, Hershfeld A, Kenyon L, et al. Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2016;310:L365-76 pubmed publisher
  7. Wölfle U, Haarhaus B, Seiwerth J, Cawelius A, Schwabe K, Quirin K, et al. The Herbal Bitter Drug Gentiana lutea Modulates Lipid Synthesis in Human Keratinocytes In Vitro and In Vivo. Int J Mol Sci. 2017;18: pubmed publisher
    ..a characteristic bitter compound of Gentiana lutea extract (GE), binds to the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes, and stimulates the synthesis of epidermal barrier proteins...
  8. Shan L, Wu Q, Wang L, Zhang L, Wei F. Lineage-specific evolution of bitter taste receptor genes in the giant and red pandas implies dietary adaptation. Integr Zool. 2018;13:152-159 pubmed publisher
    ..The purifying selection on TAS2R1, TAS2R9 and TAS2R38 in the giant panda, and TAS2R62 in the red panda, has been strengthened throughout the course ..
  9. Firestein S. The good taste of genomics. Nature. 2000;404:552-3 pubmed
  10. Singh N, Pydi S, Upadhyaya J, Chelikani P. Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs). J Biol Chem. 2011;286:36032-41 pubmed publisher
    ..In this study, the bitter receptor T2R1 was used to systematically investigate the role of 15 transmembrane amino acids in T2Rs, including 13 highly ..
  11. Matsunami H, Montmayeur J, Buck L. A family of candidate taste receptors in human and mouse. Nature. 2000;404:601-4 pubmed
    ..Another TRB gene is found on a human contig assigned to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil in humans. ..