Gene Symbol: TARSH
Description: ABI family member 3 binding protein
Alias: NESHBP, TARSH, target of Nesh-SH3, ABI family, member 3 (NESH) binding protein, ABI gene family member 3-binding protein, ABI gene family, member 3 (NESH) binding protein, nesh-binding protein
Species: human
Products:     TARSH

Top Publications

  1. Willis Owen S, Thompson A, Kemp P, Polkey M, Cookson W, Moffatt M, et al. COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix. Sci Rep. 2018;8:12165 pubmed publisher
    ..COPD is accompanied by coordinated patterns of transcription in the quadriceps involving the mitochondria and extracellular matrix and including genes previously implicated in primary disease processes. ..
  2. Hodgkinson C, Gomez J, Payne A, Zhang L, Wang X, Dal Pra S, et al. Abi3bp regulates cardiac progenitor cell proliferation and differentiation. Circ Res. 2014;115:1007-16 pubmed publisher
    ..Abi3bp controlled CPC differentiation via integrin-β1, protein kinase C-ζ, and v-akt murine thymoma viral oncogene homolog. We have identified Abi3bp as a protein important for CPC differentiation and proliferation. ..
  3. Rose Martel M, Smiley S, Hincke M. Novel identification of matrix proteins involved in calcitic biomineralization. J Proteomics. 2015;116:81-96 pubmed publisher
    ..We hypothesize that these proteins regulate the earliest stages of eggshell calcification. The human homologs of these proteins are therefore potential candidates to play a role in otoconia biomineralization. ..
  4. Kimbrel N, Garrett M, Dennis M, Hauser M, Ashley Koch A, Beckham J. A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans. Psychiatry Res. 2018;269:64-69 pubmed publisher
    ..Additional work aimed at replicating and extending these findings is needed. ..
  5. Yang H, Chen W, Shi J, Huang D, Li J, Hu B, et al. Knockout of Abi3bp in mice does not affect their olfactory function, mental state and NNK-induced lung tumorigenesis. Acta Biochim Biophys Sin (Shanghai). 2016;48:820-6 pubmed publisher
    ..These data suggest that the function of Abi3bp in in vitro models does not translate to a similar role in the intact animal. Its depletion may be compensated by other genes, which needs to be addressed in future studies. ..
  6. Radder J, Gregory A, Leme A, Cho M, Chu Y, Kelly N, et al. Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility. Am J Respir Cell Mol Biol. 2017;57:367-375 pubmed publisher
    ..This is the first report of susceptibility to cigarette smoke-induced emphysema in 34 inbred strains of mice, and Abi3bp is identified as a potential contributor to this phenotype. ..
  7. Terauchi K, Shimada J, Uekawa N, Yaoi T, Maruyama M, Fushiki S. Cancer-associated loss of TARSH gene expression in human primary lung cancer. J Cancer Res Clin Oncol. 2006;132:28-34 pubmed
    We have previously identified mouse Tarsh as one of the cellular senescence-related genes and showed the loss of expression of TARSH mRNA in four human lung cancer cell lines...
  8. Wakoh T, Uekawa N, Terauchi K, Sugimoto M, Ishigami A, Shimada J, et al. Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression. Biochem Biophys Res Commun. 2009;380:807-12 pubmed publisher
    A novel target of NESH-SH3 (TARSH) was identified as a cellular senescence related gene in mouse embryonic fibroblasts (MEFs) replicative senescence, the expression of which has been suppressed in primary clinical lung cancer specimens...
  9. Cornejo Garcia J, Liou L, Blanca Lopez N, Doña I, Chen C, Chou Y, et al. Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. Pharmacogenomics. 2013;14:1857-69 pubmed publisher
    ..The associations described were different from those related to the metabolism of arachidonic acid and could provide new mechanisms underlying NSAID-induced AUA. ..

More Information


  1. Matsuda S, Iriyama C, Yokozaki S, Ichigotani Y, Shirafuji N, Yamaki K, et al. Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. J Hum Genet. 2001;46:483-6 pubmed
    ..Polymerase Chair reaction-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels localized the gene on human chromosome 3q12 near the marker D3S1271. ..
  2. Uekawa N, Terauchi K, Nishikimi A, Shimada J, Maruyama M. Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer. Biochem Biophys Res Commun. 2005;329:1031-8 pubmed
    ..We also show that mTARSH mRNA predominantly expressed in lung and that conspicuous expression of TARSH was drastically declined in all several lung cancer cell lines we tested...
  3. Zhang F, Guo X, Zhang Y, Wen Y, Wang W, Wang S, et al. Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease. Hum Genet. 2014;133:793-9 pubmed publisher
    ..Gene expression analysis also found that ABI3BP was up-regulated in KBD patients compared to healthy controls. Our results suggest that ABI3BP was a novel susceptibility gene for KBD. ..
  4. Latini F, Hemerly J, Oler G, Riggins G, Cerutti J. Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion. Endocr Relat Cancer. 2008;15:787-99 pubmed publisher
    ..Together, our data provide evidence that the loss of ABI3BP expression could play a functional role in thyroid tumorigenesis. Activation of ABI3BP or its pathway may represent a possible basis for targeted therapy of certain cancers. ..
  5. Perlis R, Huang J, Purcell S, Fava M, Rush A, Sullivan P, et al. Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry. 2010;167:1499-507 pubmed publisher
    ..They nonetheless provide suggestive evidence for multiple loci, which merit further investigation. ..
  6. Ding L, Abebe T, Beyene J, Wilke R, Goldberg A, Woo J, et al. Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations. Hum Genomics. 2013;7:16 pubmed publisher
    ..Variants that are associated with asthma across populations could be used to identify individuals who are at high risk for asthma regardless of genetic ancestry. ..