TAP2

Summary

Gene Symbol: TAP2
Description: transporter 2, ATP binding cassette subfamily B member
Alias: ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11, antigen peptide transporter 2, ABC transporter, MHC 2, ATP-binding cassette, sub-family B (MDR/TAP), member 3, peptide supply factor 2, peptide transporter PSF2, peptide transporter involved in antigen processing 2, really interesting new gene 11 protein, transporter 2, ABC (ATP binding cassette), transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Species: human
Products:     TAP2

Top Publications

  1. Powis S, Tonks S, Mockridge I, Kelly A, Bodmer J, Trowsdale J. Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. Immunogenetics. 1993;37:373-80 pubmed
    TAP1 and TAP2 are two major histocompatibility complex (MHC) genes, located between HLA-DP and -DQ, whose products form a transporter molecule involved in endogenous antigen processing...
  2. Zhang S, Chabod J, Penfornis A, Reviron D, Tiberghien P, Wendling D, et al. TAP1 and TAP2 gene polymorphism in rheumatoid arthritis in a population in eastern France. Eur J Immunogenet. 2002;29:241-9 pubmed
    ..In this study, we examined the polymorphism of TAP1 and TAP2 genes in patients with rheumatoid arthritis (RA)...
  3. Correa P, Molina J, Pinto L, Arcos Burgos M, Herrera M, Anaya J. TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. Ann Rheum Dis. 2003;62:363-5 pubmed
    To determine the influence of TAP1 and TAP2 alleles in northwestern Colombian patients with systemic lupus erythematosus (SLE).
  4. Koch J, Guntrum R, Heintke S, Kyritsis C, Tampe R. Functional dissection of the transmembrane domains of the transporter associated with antigen processing (TAP). J Biol Chem. 2004;279:10142-7 pubmed
    ..time that the translocation pore of the transporter is composed of the predicted TM-(5-10) of TAP1 and TM-(4-9) of TAP2. Moreover, we demonstrate that the N-terminal domains of TAP1 and TAP2 are essential for recruitment of tapasin, ..
  5. Yu M, Huang C, Wu M, Wu J, Tsai F. Association of TAP2 gene polymorphisms in Chinese patients with rheumatoid arthritis. Clin Rheumatol. 2004;23:35-9 pubmed
    ..to investigate the association between the polymorphism of transporters associated with antigen processing ( TAP1/TAP2) genes and rheumatoid arthritis in Chinese patients...
  6. Procko E, Raghuraman G, Wiley D, Raghavan M, Gaudet R. Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I. Immunol Cell Biol. 2005;83:475-82 pubmed
    ..ER), MHC class I molecules transiently associate with the transporter associated with antigen processing (TAP1/TAP2) in an interaction that is bridged by tapasin...
  7. Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. Nature. 1990;348:741-4 pubmed
    ..This superfamily includes the human multidrug-resistance protein, and a series of transporters from bacteria and eukaryotic cells capable of transporting a range of substrates, including peptides. ..
  8. Gaudet R, Wiley D. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. EMBO J. 2001;20:4964-72 pubmed
    The transporter associated with antigen processing (TAP) is an ABC transporter formed of two subunits, TAP1 and TAP2, each of which has an N-terminal membrane-spanning domain and a C-terminal ABC ATPase domain...
  9. Takeuchi K, Abe S, Masuda S, Yuta A, Majima Y, Sakakura Y. Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese population. Ann Otol Rhinol Laryngol. 2002;111:460-3 pubmed
    Gene products of TAP1 and TAP2 (transporters associated with antigen processing) are involved in antigen presentation. It has been reported that polymorphisms in the TAP1 gene are associated with atopy in Tunisians...

More Information

Publications112 found, 100 shown here

  1. Kanagawa S, Morinobu A, Koshiba M, Kageyama G, Hayashi N, Yoshino S, et al. Association of the TAP2*Bky2 allele with presence of SS-A/Ro and other autoantibodies in Japanese patients with systemic lupus erythematosus. Lupus. 2003;12:258-65 pubmed
    We previously reported that a new allele of transporter associated with antigen processing (TAP) 2 gene, TAP2*Bky2 (Val577), was significantly increased in Japanese patients with Sjögren's syndrome (SS) and had a strong association with ..
  2. Leonhardt R, Keusekotten K, Bekpen C, Knittler M. Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex. J Immunol. 2005;175:5104-14 pubmed
    ..by recruiting MHC I and accessory chaperones to the N-terminal regions (N domains) of the TAP subunits TAP1 and TAP2. To investigate the function of the tapasin-docking sites of TAP in MHC I processing, we expressed N-terminally ..
  3. Alvarado Guerri R, Cabrera C, Garrido F, Lopez Nevot M. TAP1 and TAP2 polymorphisms and their linkage disequilibrium with HLA-DR, -DP, and -DQ in an eastern Andalusian population. Hum Immunol. 2005;66:921-30 pubmed
    ..We studied 105 unrelated individuals from Eastern Andalusia in Southern Spain for TAP1 and TAP2 polymorphisms and to detect linkage disequilibrium between TAP1 and TAP2 and between TAP1/TAP2 and human lymphocyte ..
  4. Koch J, Guntrum R, Tampe R. The first N-terminal transmembrane helix of each subunit of the antigenic peptide transporter TAP is essential for independent tapasin binding. FEBS Lett. 2006;580:4091-6 pubmed
    ..We found that the N-terminal domains of human TAP1 and TAP2 can independently bind to tapasin, thus providing two separate loading platforms for PLC assembly...
  5. Rufer E, Leonhardt R, Knittler M. Molecular architecture of the TAP-associated MHC class I peptide-loading complex. J Immunol. 2007;179:5717-27 pubmed
    ..MHC class I (MHC-I) and accessory chaperones to the N-terminal regions of the TAP subunits TAP1 and TAP2. Despite numerous studies have shown that the formation of the PLC is essential to facilitate proper MHC-I loading, ..
  6. Lee H, Lee A, Criswell L, Seldin M, Amos C, Carulli J, et al. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. Mol Med. 2008;14:293-300 pubmed publisher
    ..association signals were found in the extreme centromeric portion of the MHC, in regions containing the DOB1, TAP2, DPB1, and COL11A2 genes...
  7. Einstein M, Leanza S, Chiu L, Schlecht N, Goldberg G, Steinberg B, et al. Genetic variants in TAP are associated with high-grade cervical neoplasia. Clin Cancer Res. 2009;15:1019-23 pubmed publisher
    ..Five nonsynonymous single nucleotide polymorphisms (SNP) in TAP1 and TAP2 were genotyped using DNA collected in cervicovaginal lavage samples using microsphere array technology (Luminex ..
  8. Kordi Tamandani D, Sobti R, Shekari M, Husseini S, Suri V. No association of TAP1 and TAP2 genes polymorphism with risk of cervical cancer in north Indian population. J Assist Reprod Genet. 2009;26:173-8 pubmed publisher
    ..Mutations and/or polymorphism within these genes could alter the efficacy of the immune response which might be relevant for the development of autoimmune diseases and cancer...
  9. Kim K, Cho S, Choi S, Jeong J, Lee S, Park C, et al. TAP1 and TAP2 gene polymorphisms in Korean patients with allergic rhinitis. J Korean Med Sci. 2007;22:825-31 pubmed
    ..TAP1 and TAP2 genotyping were performed on 110 allergic rhinitis patients and 107 healthy controls...
  10. Oancea G, O Mara M, Bennett W, Tieleman D, Abele R, Tampe R. Structural arrangement of the transmission interface in the antigen ABC transport complex TAP. Proc Natl Acad Sci U S A. 2009;106:5551-6 pubmed publisher
    ..These results resolve the structural arrangement of the transmission interface and point to different functions of the cytosolic loops and coupling helices in substrate binding, signaling, and transport...
  11. Sheyhidin I, Hasim A, Zheng F, Ma H. Epigenetic changes within the promoter regions of antigen processing machinery family genes in Kazakh primary esophageal squamous cell carcinoma. Asian Pac J Cancer Prev. 2014;15:10299-306 pubmed
    ..we showed that the development of ESCCs was accompanied by partial or total loss of protein expression of HLA-B, TAP2, LMP7, tapasin and ERp57...
  12. Wang A, Liu F, Chen S, Wang M, Jia R, Zhu D, et al. Transcriptome Analysis and Identification of Differentially Expressed Transcripts of Immune-Related Genes in Spleen of Gosling and Adult Goose. Int J Mol Sci. 2015;16:22904-26 pubmed publisher
    ..interleukin 2 receptor alpha (IL2RA), MHC class I heavy chain (MHCIα), transporter of antigen processing 2 (TAP2) IgH, were confirmed by quantitative real-time PCR (qRT-PCR)...
  13. Zeidler R, Eissner G, Meissner P, Uebel S, Tampe R, Lazis S, et al. Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10. Blood. 1997;90:2390-7 pubmed
    ..Similarly, hIL-10 showed the same activity. Expression of the LMP2 and TAP1 genes but not expression of TAP2 or LMP7 is efficiently downregulated, indicating a specific IL-10 effect on the two divergently transcribed TAP1 ..
  14. Quadri S, Singal D. Peptide transport in human lymphoblastoid and tumor cells: effect of transporter associated with antigen presentation (TAP) polymorphism. Immunol Lett. 1998;61:25-31 pubmed
    ..Moreover, TAP2 polymorphisms have no influence on the peptide translocation in normal or tumor cell lines...
  15. Bomberger J, Ely K, Bangia N, Ye S, Green K, Green W, et al. Pseudomonas aeruginosa Cif protein enhances the ubiquitination and proteasomal degradation of the transporter associated with antigen processing (TAP) and reduces major histocompatibility complex (MHC) class I antigen presentation. J Biol Chem. 2014;289:152-62 pubmed publisher
    ..Cif enhances the ubiquitination and degradation of the transporter associated with antigen processing (TAP1 and TAP2), members of the ABC transporter family that play an essential role in antigen presentation and intracellular ..
  16. Hu G, Caza M, Bakkeren E, Kretschmer M, Bairwa G, Reiner E, et al. A P4-ATPase subunit of the Cdc50 family plays a role in iron acquisition and virulence in Cryptococcus neoformans. Cell Microbiol. 2017;19: pubmed publisher
    ..A comparison of phenotypes with mutants defective in genes encoding candidate flippases (designated APT1, APT2, APT3, and APT4) revealed similarities primarily between cdc50 and apt1 suggesting a potential functional ..
  17. Li S, Sjogren H, Hellman U, Pettersson R, Wang P. Cloning and functional characterization of a subunit of the transporter associated with antigen processing. Proc Natl Acad Sci U S A. 1997;94:8708-13 pubmed
    ..We propose that TAP is a trimeric complex consisting of TAP1, TAP2, and TAP-A that interacts transiently with class I HC/beta2-m...
  18. Geng J, Zaitouna A, Raghavan M. Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP). PLoS Pathog. 2018;14:e1007171 pubmed publisher
    ..Approximately 15% of tested HLA-B allotypes are expressed at relatively high levels on the surface of TAP1 or TAP2-deficient cells and occur in partially peptide-receptive forms and Endoglycosidase H sensitive forms on the cell ..
  19. Laud P, Loflin P, Jeevan A, Lawlor D. Transporter associated with antigen-processing-1 (TAP1) alleles in Gorilla gorilla: diversification of the locus postspeciation. Hum Immunol. 1996;50:91-102 pubmed
    ..2%) or between the two hominoid species (0.8%). Nucleotide substitution analysis demonstrates that TAP1 and TAP2 are evolving at comparable rates under similar selection pressures...
  20. Carbotti G, Nikpoor A, Vacca P, Gangemi R, Giordano C, Campelli F, et al. IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells. J Exp Clin Cancer Res. 2017;36:140 pubmed publisher
    ..triggered STAT1/3 phosphorylation and up-regulated the expression of surface HLA class I antigen and of TAP1 and TAP2 mRNA in four out of five SCLC cell lines tested...
  21. Robinson P, Leo P, Pointon J, Harris J, Cremin K, Bradbury L, et al. The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis. Genes Immun. 2016;17:46-51 pubmed publisher
    ..Secondary independent association with PSORS1C3 (P=4.7 × 10(-5)) and TAP2 (P=1.1 × 10(-5)) were observed in the major histocompatibility complex...
  22. Flori L, Rogel Gaillard C, Mariani V, Lemonnier G, Cochet M, Hugot K, et al. A combined transcriptomic approach to analyse the dialogue between pseudorabies virus and porcine cells. Dev Biol (Basel). 2008;132:99-104 pubmed
    ..Several genes involved in the MHC class I mediated antigenic pathway were downregulated including SLA-la, TAP1, TAP2, PSMB8 and PSMB9 genes...
  23. Huang P, Dong L, Lu X, Zhang Y, Chen H, Wang J, et al. Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study. BMC Infect Dis. 2014;14:716 pubmed publisher
    ..34 tagging-SNPs (single nucleotide polymorphisms) from 9 candidate genes (HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, TAP1, TAP2, LMP2, LMP7, and tapasin) in a Chinese population of paid blood donors with high risk of HCV infection...
  24. Ambagala A, Feng Z, Barletta R, Srikumaran S. Molecular cloning, sequencing, and characterization of bovine transporter associated with antigen processing 2 ( BoTAP2). Immunogenetics. 2002;54:30-8 pubmed
    ..BoTAP2 has approximately 80% homology, at the amino acid level, to its mammalian counterparts. Similar to human TAP2, BoTAP2 consists of seven putative transmembrane segments followed by an ATP-binding cassette...
  25. Grimholt U. Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. BMC Evol Biol. 2018;18:25 pubmed publisher
    ..At least in chicken, such MHCIa haplotypes of MHCIa, TAP2 and Tapasin are shown to influence the repertoire of pathogen epitopes being presented to CD8+ T-cells with ..
  26. Salazar Onfray F, Charo J, Petersson M, Freland S, Noffz G, Qin Z, et al. Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10. J Immunol. 1997;159:3195-202 pubmed
    ..peptides are delivered to the secretory pathway by TAP, which is formed by the association of MHC-encoded TAP1 and TAP2 gene products...
  27. Akuta N, Chayama K, Suzuki F, Someya T, Kobayashi M, Tsubota A, et al. Risk factors of hepatitis C virus-related liver cirrhosis in young adults: positive family history of liver disease and transporter associated with antigen processing 2(TAP2)*0201 Allele. J Med Virol. 2001;64:109-16 pubmed
    ..and family history were investigated, and the frequency of transporter associated with antigen processing 2 (TAP2) was determined. A family history of liver disease was present in 40.7% of Group LC but in 18...
  28. Chiang E, Henson M, Stroynowski I. Correction of defects responsible for impaired Qa-2 class Ib MHC expression on melanoma cells protects mice from tumor growth. J Immunol. 2003;170:4515-23 pubmed
    ..B78H1, unlike B16F1 and B16F10 sublines, is also selectively devoid of TAP2 and low molecular weight protein 7 as well as classical class I MHC K(b) and D(b) transcripts...
  29. Walker B, Hunt L, Sowa A, Skjødt K, Göbel T, Lehner P, et al. The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes. Proc Natl Acad Sci U S A. 2011;108:8396-401 pubmed publisher
    ..Here we report TAP1 and TAP2 sequences from 16 chicken lines, and show that both genes have high allelic polymorphism and moderate sequence ..
  30. Furukawa H, Murata S, Yabe T, Shimbara N, Keicho N, Kashiwase K, et al. Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome. J Clin Invest. 1999;103:755-8 pubmed
    ..the cell surface depends on the heterodimer of the transporter associated with antigen processing 1 and 2 (TAP1 and TAP2), which transport peptides cleaved by proteasome to the class I molecules...
  31. Ritz U, Momburg F, Pircher H, Strand D, Huber C, Seliger B. Identification of sequences in the human peptide transporter subunit TAP1 required for transporter associated with antigen processing (TAP) function. Int Immunol. 2001;13:31-41 pubmed
    The heterodimeric peptide transporter associated with antigen processing (TAP) consisting of the subunits TAP1 and TAP2 mediates the transport of cytosolic peptides into the lumen of the endoplasmic reticulum (ER)...
  32. Fromm S, Duady Ben Yaakov S, Schechter C, Ehrlich R. Assembly and cell surface expression of TAP-independent, chloroquine-sensitive and interferon-gamma-inducible class I MHC complexes in transformed fibroblast cell lines are regulated by tapasin. Cell Immunol. 2002;215:207-18 pubmed
    ..We now characterize a TAP-independent pathway that is operative in both TAP1- and TAP2-deficient Adenovirus (Ad)-transformed fibroblast cell lines...
  33. Qian Y, Wang G, Xue F, Chen L, Wang Y, Tang L, et al. Genetic association between TAP1 and TAP2 polymorphisms and ankylosing spondylitis: a systematic review and meta-analysis. Inflamm Res. 2017;66:653-661 pubmed publisher
    ..The aim of our meta-analysis was to investigate the contribution of TAP (TAP1 and TAP2) polymorphisms to the risk of AS...
  34. Mesa C, Thulien K, Moon D, Veniamin S, Magor K. The dominant MHC class I gene is adjacent to the polymorphic TAP2 gene in the duck, Anas platyrhynchos. Immunogenetics. 2004;56:192-203 pubmed
    ..In chickens, the dominantly expressed MHC class I gene lies adjacent to the transporter of antigen processing ( TAP2) gene...
  35. Pickering A, Lehr M, Miller R. Lifespan of mice and primates correlates with immunoproteasome expression. J Clin Invest. 2015;125:2059-68 pubmed publisher
    ..in other elements involved in MHC class I antigen presentation, including β-2 microglobulin, (TAP1), and TAP2. Fibroblasts from long-lived primates also appeared more responsive to IFN-γ than cells from short-lived primate ..
  36. van Hall T, Laban S, Koppers Lalic D, Koch J, Precup C, Asmawidjaja P, et al. The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1. J Immunol. 2007;178:657-62 pubmed
    ..to ICP47 and US6, strongly impairs the activity of the mouse transporter and mediates degradation of mouse TAP1 and TAP2. Inhibition of TAP was witnessed by a strong reduction of surface MHC class I display and a decrease in recognition ..
  37. Seyffer F, Tampe R. ABC transporters in adaptive immunity. Biochim Biophys Acta. 2015;1850:449-60 pubmed publisher
    ..Briefly, ATP-dependent flipping between inward- and outward-facing conformations allows directional transport of various solutes...
  38. Huang P, Zhang Y, Lu X, Xu Y, Wang J, Zhang Y, et al. Association of polymorphisms in HLA antigen presentation-related genes with the outcomes of HCV infection. PLoS ONE. 2015;10:e0123513 pubmed publisher
    ..Our study implicated that TAP2, HLA-DOA, HLA-DOB, and tapasin loci were novel candidate regions for susceptibility to HCV infection and viral ..
  39. Litviakov N, Cherdyntseva N, Tsyganov M, Slonimskaya E, Ibragimova M, Kazantseva P, et al. Deletions of multidrug resistance gene loci in breast cancer leads to the down-regulation of its expression and predict tumor response to neoadjuvant chemotherapy. Oncotarget. 2016;7:7829-41 pubmed publisher
    ..03 × 10(-11), Fisher test, Bonferroni-adjusted p = 1.73 × 10(-8)). In conclusion, our study for the first time demonstrates that deletion MDR gene loci can be used as predictive marker for tumor response to NAC. ..
  40. Meyer zu Horste G, Heidenreich H, Lehmann H, Ferrone S, Hartung H, Wiendl H, et al. Expression of antigen processing and presenting molecules by Schwann cells in inflammatory neuropathies. Glia. 2010;58:80-92 pubmed publisher
    ..cultured human Schwann cells increase the expression of proteasome subunit delta (Y), antigen peptide transporter TAP2, and HLA Class I and HLA Class II complexes in an inflammatory environment...
  41. Knittler M, Alberts P, Deverson E, Howard J. Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I molecules. Curr Biol. 1999;9:999-1008 pubmed
    ..To investigate the role of TAP in this process, mutations that block nucleotide binding were introduced into the ATP-binding site of TAP...
  42. Kobayashi T, Yokoyama I, Inoko H, Naruse T, Hayashi S, Morozumi K, et al. Significance of transporter associated with antigen processing gene polymorphism in living related renal transplantation. Hum Immunol. 2000;61:670-4 pubmed
    ..The purpose of this study was to examine whether MHC-encoded antigen processing (TAP1, TAP2, LMP2, DMA and DMB) gene polymorphisms were associated with the incidence and the severity of acute rejection after ..
  43. Abrami L, Dallavilla T, Sandoz P, Demir M, Kunz B, Savoglidis G, et al. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. elife. 2017;6: pubmed publisher
    ..We found that species rapidly interconvert through the action of ZDHHC16 and the Acyl Protein Thioesterase APT2, that each species varies in terms of turnover rate and activity, altogether allowing the cell to robustly tune its ..
  44. Russ G, Esquivel F, Yewdell J, Cresswell P, Spies T, Bennink J. Assembly, intracellular localization, and nucleotide binding properties of the human peptide transporters TAP1 and TAP2 expressed by recombinant vaccinia viruses. J Biol Chem. 1995;270:21312-8 pubmed
    ..TAP is comprised of two subunits, termed TAP1 and TAP2. We produced recombinant vaccinia viruses that direct synthesis of the TAP subunits, either individually or ..
  45. Neefjes J, Momburg F, Hammerling G. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science. 1993;261:769-71 pubmed
    ..Two MHC-encoded putative transporter proteins, TAP1 and TAP2, are required for efficient assembly of class I molecules and presentation of endogenous peptides...
  46. Zhang S, Penfornis A, Harraga S, Chabod J, Beurton I, Bresson Hadni S, et al. Polymorphisms of the TAP1 and TAP2 genes in human alveolar echinococcosis. Eur J Immunogenet. 2003;30:133-9 pubmed
    ..Six coding region variants (codons 333 and 637 in TAP1, and 379, 565, 651 and 665 in TAP2) were typed in 94 patients and 100 controls...
  47. Hansen J, Strassburger P, Thorgaard G, Young W, Du Pasquier L. Expression, linkage, and polymorphism of MHC-related genes in rainbow trout, Oncorhynchus mykiss. J Immunol. 1999;163:774-86 pubmed
    ..Aside from the expected polymorphisms associated with class I genes, LMP2 and TAP2 are polygenic...
  48. Daumke O, Knittler M. Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domains. Eur J Biochem. 2001;268:4776-86 pubmed
    ..TAP consists of two polypeptides (TAP1 and TAP2) each with an N-terminal transmembrane (TMD) and a C-terminal nucleotide binding domain (NBD)...
  49. Thuring C, Follin E, Geironson L, Freyhult E, Junghans V, Harndahl M, et al. HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma. Br J Cancer. 2015;113:952-62 pubmed publisher
    ..Moreover, tapasin also correlated to survival of glioblastoma patients. Some APM components, for example, TAP1/TAP2 and LMP2/LMP7, showed variable but coordinated expression, whereas ERAP1/ERAP2 displayed an imbalanced expression ..
  50. Fellerhoff B, Wank R. Transporter associated with antigen processing and the chaperone tapasin: are non-classical HLA genes keys to the pathogenesis of schizophrenia?. Med Hypotheses. 2009;72:535-8 pubmed publisher
    ..a small group of schizophrenic patients and control individuals allele frequencies of the transporter proteins TAP1/TAP2, which select the immunoproteasome-tailored peptides for transportation...
  51. Albanese M, Tagawa T, Bouvet M, Maliqi L, Lutter D, Hoser J, et al. Epstein-Barr virus microRNAs reduce immune surveillance by virus-specific CD8+ T cells. Proc Natl Acad Sci U S A. 2016;113:E6467-E6475 pubmed
    ..EBV miRNAs directly target the peptide transporter subunit TAP2 and reduce levels of the TAP1 subunit, MHC class I molecules, and EBNA1, a protein expressed in most forms of EBV ..
  52. Praest P, Luteijn R, Brak Boer I, Lanfermeijer J, Hoelen H, Ijgosse L, et al. The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins. Mol Immunol. 2018;101:55-64 pubmed publisher
    ..This ER-resident transporter is composed of the proteins TAP1 and TAP2, and plays a crucial role in the loading of viral peptides onto MHC class I molecules...
  53. Xiao X, Hao J, Wen Y, Wang W, Guo X, Zhang F. Genome-wide association studies and gene expression profiles of rheumatoid arthritis: An analysis. Bone Joint Res. 2016;5:314-9 pubmed publisher
    ..For RA synovium, the top-ranked gene module is HLA-A, containing TAP2, HLA-A, HLA-C, TAPBP and LILRB1 genes...
  54. Lampton P, Goldstein C, Warner C. The role of tapasin in MHC class I protein trafficking in embryos and T cells. J Reprod Immunol. 2008;78:28-39 pubmed
    ..Here, we report the detection of mRNA for four chaperone molecules (TAP1, TAP2, calnexin and tapasin) in preimplantation embryos...
  55. Burrows C, Kosova G, Herman C, Patterson K, Hartmann K, Velez Edwards D, et al. Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes. PLoS Genet. 2016;12:e1005858 pubmed publisher
    ..Two eSNPs were associated with fecundability at a FDR of 5%; both were in the HLA region and were eQTLs for the TAP2 gene (P = 1.3x10-4) and the HLA-F gene (P = 4.0x10-4), respectively...
  56. Carrington M, Colonna M, Spies T, Stephens J, Mann D. Haplotypic variation of the transporter associated with antigen processing (TAP) genes and their extension of HLA class II region haplotypes. Immunogenetics. 1993;37:266-73 pubmed
    ..requires active transport of antigenic peptides across the endoplasmic reticulum by products of two genes, TAP1 and TAP2, which map in the major histocompatibility complex class II region...
  57. Kobayashi A, Maeda T, Maeda M. Membrane localization of transporter associated with antigen processing (TAP)-like (ABCB9) visualized in vivo with a fluorescence protein-fusion technique. Biol Pharm Bull. 2004;27:1916-22 pubmed
    ..protein belonging to subfamily B highly homologous to the TAP, a hetero-dimeric complex consisting of a TAP1 and a TAP2 subunit...
  58. Ozbaş Gerçeker F, Ozcelik U, Kiper N, Anadol D, Ayhan G, Yilmaz E, et al. Analysis of the modifying effects of TAP 1/2 genes on cystic fibrosis phenotype. Turk J Pediatr. 2002;44:91-7 pubmed
    Phenotypic variability has been reported in cystic fibrosis (CF) patients. TAP1 and TAP2 genes are encoding "the transporter associated with antigen processing" proteins...
  59. Bullido M, Martinez Garcia A, Artiga M, Aldudo J, Sastre I, Gil P, et al. A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers. Neurobiol Aging. 2007;28:519-23 pubmed
    ..Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case-control samples, especially in carriers of the ..
  60. Moschonas A, Kouraki M, Knox P, Thymiakou E, Kardassis D, Eliopoulos A. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol Cell Biol. 2008;28:6208-22 pubmed publisher
    ..of NF-kappaB and IRF-1 to the promoters of the genes encoding transporter for antigen processing 1 (TAP1), TAP2, tapasin, and low-molecular-mass polypeptides LMP2 and LMP10...
  61. Raghuraman G, Lapinski P, Raghavan M. Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes. J Biol Chem. 2002;277:41786-94 pubmed
    ..Two subunits, TAP1 and TAP2, are necessary and sufficient for peptide binding and peptide translocation across the endoplasmic reticulum ..
  62. Park S, Shin H, Shah M, Cho H, Anwar M, Achek A, et al. TLR4/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation. Biomaterials. 2017;126:49-60 pubmed publisher
    ..Among these, TAP2 specifically halted the TLR4, but not other TLRs signaling, which was further confirmed by the biophysical kinetic ..
  63. Bodmer J, Marsh S, Albert E, Bodmer W, Dupont B, Erlich H, et al. Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. Tissue Antigens. 1992;39:161-73 pubmed
  64. Herberg J, Sgouros J, Jones T, Copeman J, Humphray S, Sheer D, et al. Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. Eur J Immunol. 1998;28:459-67 pubmed
    ..The gene was centromeric of the HLA-DP locus between the HSET and HKE1.5 genes and within 500 kbp of the TAP1 and TAP2 genes. A homologous mouse EST was mapped to a syntenic position on chromosome 17, centromeric of the H-2 K locus...
  65. Shen W, Shen T, Yin B, Zheng J, Liu D, Feng M. [Distribution of tap1 and tap2 loci allelic and genotypic frequencies in Chinese Hans]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009;17:777-81 pubmed
    ..aimed to investigate the distribution and implication of tap1 (transporter associated with antigen processing) and tap2 loci allelic and genotypic frequencies...
  66. Hammond S, Johnson R, Kalams S, Walker B, Takiguchi M, Safrit J, et al. An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL. J Immunol. 1995;154:6140-56 pubmed
  67. Kumagai S, Kanagawa S, Morinobu A, Takada M, Nakamura K, Sugai S, et al. Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjögren's syndrome. Arthritis Rheum. 1997;40:1685-92 pubmed
  68. Velarde G, Ford R, Rosenberg M, Powis S. Three-dimensional structure of transporter associated with antigen processing (TAP) obtained by single Particle image analysis. J Biol Chem. 2001;276:46054-63 pubmed
    ..Immunoaffinity-purified TAP particles comprising TAP1 and TAP2 polypeptides, and TAP2 particles alone were characterized after detergent solubilization and studied by electron ..
  69. Park B, Lee S, Kim E, Cho K, Riddell S, Cho S, et al. Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. Cell. 2006;127:369-82 pubmed publisher
    ..These results establish a link between thiol-based redox regulation and antigen processing...
  70. Ramos P, Langefeld C, Bera L, Gaffney P, Noble J, Moser K. Variation in the ATP-binding cassette transporter 2 gene is a separate risk factor for systemic lupus erythematosus within the MHC. Genes Immun. 2009;10:350-5 pubmed publisher
    ..We tested if variation in the TAP genes (TAP1 and TAP2) is associated with SLE...
  71. Shi C, Qian Y, Su J, Luo S, Gu J, You H, et al. Genetic variation in the LMP/TAP gene and outcomes of hepatitis B virus infection in the Chinese population. Epidemiol Infect. 2011;139:674-82 pubmed publisher
    ..These findings indicated that genetic polymorphisms of the LMP/TAP gene might be an important factor in determining the outcome of HBV infection. ..
  72. Yang X, Sun J, Gao Y, Tan A, Zhang H, Hu Y, et al. Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects. PLoS Genet. 2012;8:e1002916 pubmed publisher
    ..Our study is the first GWAS report which shows genetic components influence the levels of complement C3 and C4. Our significant findings provide novel insights of their related autoimmune, infectious diseases, and molecular mechanisms...
  73. Natter C, Polterauer S, Rahhal Schupp J, Cacsire Castillo Tong D, Pils S, Speiser P, et al. Association of TAP gene polymorphisms and risk of cervical intraepithelial neoplasia. Dis Markers. 2013;35:79-84 pubmed publisher
    ..TAP seems to facilitate the detection of HPV by MHC-I molecules and contributes to successful eradication of HPV. TAP polymorphisms could have an important impact on the course of HPV infection...
  74. Gan C, Yusof R, Othman S. Different serotypes of dengue viruses differently regulate the expression of the host cell antigen processing machinery. Acta Trop. 2015;149:8-14 pubmed publisher
    ..Cellular RNA were isolated from infected cells and the gene expressions of LMP2, LMP7, TAP1, TAP2, TAPBP, CALR, CANX, PDIA3, HLA-A and HLA-B were analyzed via quantitative PCR...
  75. Geng J, Pogozheva I, Mosberg H, Raghavan M. Use of Functional Polymorphisms To Elucidate the Peptide Binding Site of TAP Complexes. J Immunol. 2015;195:3436-48 pubmed publisher
    TAP1/TAP2 complexes translocate peptides from the cytosol to the endoplasmic reticulum lumen to enable immune surveillance by CD8(+) T cells...
  76. Middleton D, Megaw G, Cullen C, Hawkins S, Darke C, Savage D. TAP1 and TAP2 polymorphism in multiple sclerosis patients. Hum Immunol. 1994;40:131-4 pubmed
    The frequency of TAP1 and TAP2 gene polymorphisms in MS patients was compared with that of a normal population...
  77. Powis S. Major histocompatibility complex class I molecules interact with both subunits of the transporter associated with antigen processing, TAP1 and TAP2. Eur J Immunol. 1997;27:2744-7 pubmed
    ..as described here, in the TAP-deficient human cell line T2, MHC class I molecules interact with a transfected rat TAP2 polypeptide in addition to rat TAP1. Furthermore, this interaction with TAP2 also involves calreticulin and tapasin...
  78. Morrice N, Powis S. A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules. Curr Biol. 1998;8:713-6 pubmed
    ..ERp57 co-purified with the rat TAP complex (comprising TAP1 and TAP2), and associated with MHC class I molecules at an early stage in their biosynthesis...
  79. Regnault A, Lankar D, Lacabanne V, Rodriguez A, Thery C, Rescigno M, et al. Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med. 1999;189:371-80 pubmed
    ..proteasomal degradation and is dependent on functional peptide transporter associated with antigen processing, TAP1-TAP2. By promoting DC maturation and presentation on both MHC class I and II molecules, ICs should efficiently sensitize ..
  80. Sugimoto Y, Kuzushita N, Takehara T, Kanto T, Tatsumi T, Miyagi T, et al. A single nucleotide polymorphism of the low molecular mass polypeptide 7 gene influences the interferon response in patients with chronic hepatitis C. J Viral Hepat. 2002;9:377-84 pubmed
    ..The distributions of TAP1*, TAP2*, and LMP2 genes between sustained-responders and nonresponders did not differ...
  81. Penfornis A, Yan G, Shi L, Faustman D. Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis. Hum Immunol. 2003;64:156-67 pubmed
    The human transporter associated with antigen processing (TAP1 and TAP2) genes are located in the human leukocyte antigen (HLA) class II region of the genome and encode proteins that form a heterodimer essential for the transport of ..
  82. Chen M, Abele R, Tampe R. Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing. J Biol Chem. 2003;278:29686-92 pubmed
    ..TAP is a heterodimer consisting of TAP1 and TAP2. Each subunit is composed of a transmembrane domain and a nucleotide-binding domain, which energizes the peptide ..
  83. Kiper N, Gerçeker F, Utine E, Yalcin E, Pekcan S, Cobanoglu N, et al. TAP1 and TAP2 gene polymorphisms in childhood cystic echinococcosis. Parasitol Int. 2010;59:283-5 pubmed publisher
    ..For an overview of allelic distribution of TAP1 and TAP2 genes, genotypes of 85 patients with CE and 100 controls were studied...
  84. Bravo M, Colmenero J, Queipo Ortuño M, Martin J, Lavado R, Alonso A, et al. No association of TAP and LMP genetic polymorphism in human brucellosis and its complications. Hum Immunol. 2010;71:708-11 pubmed publisher
    ..This study suggests that larger studies will be needed to confirm or rule out the possible association of the TAP2A/TAP2F genotype or other possible associations with focal forms of brucellosis...
  85. Kamei H, Masuda S, Nakamura T, Oike F, Takada Y, Hamajima N. Association of transporter associated with antigen processing (TAP) gene polymorphisms in donors with acute cellular rejection in living donor liver transplantation. J Gastrointestin Liver Dis. 2013;22:167-71 pubmed
    ..Transporter associated with antigen processing (TAP1 and TAP2) are involved in major histocompatibility complex (MHC) class I antigen-mediated processing and presentation to ..
  86. Tuncel J, Haag S, Yau A, Norin U, Baud A, Lönnblom E, et al. Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat. PLoS Genet. 2014;10:e1004151 pubmed publisher
    ..We mapped this effect to the transporter associated with antigen processing 2 (Tap2) in the MHC-II region and the classical MHC class I gene(s) (RT1-A) in the MHC-I region...
  87. Hinz A, Jedamzick J, Herbring V, Fischbach H, Hartmann J, Parcej D, et al. Assembly and function of the major histocompatibility complex (MHC) I peptide-loading complex are conserved across higher vertebrates. J Biol Chem. 2014;289:33109-17 pubmed publisher
    ..We found that avian and mammalian TAP1 and TAP2 form heterodimeric complexes across taxa...
  88. Singal D, Ye M, Qiu X, D SOUZA M. Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis. Clin Exp Rheumatol. 1994;12:29-33 pubmed
    ..In this study we investigated the polymorphisms in the ATP-binding domain of the TAP2 gene and examined the relationship of these polymorphisms to susceptibility to rheumatoid arthritis (RA)...
  89. Braud V, McMichael A, Cerundolo V. Differential processing of influenza nucleoprotein in human and mouse cells. Eur J Immunol. 1998;28:625-35 pubmed
    ..of mouse cells with recombinant vaccinia viruses encoding the full-length nucleoprotein and the human TAP1 and TAP2 peptide transporter complex failed to restore presentation...
  90. Neisig A, Melief C, Neefjes J. Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction. J Immunol. 1998;160:171-9 pubmed
    ..The restricted peptide binding of certain HLA-C alleles provides one explanation for the reduced expression of HLA-C molecules at the cell surface. Other mechanisms will be discussed...
  91. Keicho N, Tokunaga K, Nakata K, Taguchi Y, Azuma A, Tanabe K, et al. Contribution of TAP genes to genetic predisposition for diffuse panbronchiolitis. Tissue Antigens. 1999;53:366-73 pubmed
    ..Genes of the molecules implicated in the class I pathway, TAP1, TAP2 and LMP2, which are located in the HLA region of the sixth chromosome were analyzed in 76 patients with diffuse ..
  92. Tang J, Freedman D, Allen S, Karita E, Musonda R, Braga C, et al. Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans. Genes Immun. 2001;2:32-40 pubmed
    The protein forms of transporter associated with antigen processing, subunit 2 (TAP2), differ either by amino acid substitutions (Thr374Ala, Ile379Val, Ile467Val, Thr565Ala, Val577Met, Cys651Arg, and Ala665Thr) or by a truncation (..