TAP1

Summary

Gene Symbol: TAP1
Description: transporter 1, ATP binding cassette subfamily B member
Alias: ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, antigen peptide transporter 1, ABC transporter, MHC 1, ATP-binding cassette sub-family B member 2, ATP-binding cassette, sub-family B (MDR/TAP), member 2, peptide supply factor 1, peptide transporter PSF1, peptide transporter TAP1, peptide transporter involved in antigen processing 1, really interesting new gene 4 protein, transporter 1 ATP-binding cassette sub-family B, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter associated with antigen processing, transporter, ATP-binding cassette, major histocompatibility complex, 1
Species: human
Products:     TAP1

Top Publications

  1. Bahram S, Arnold D, Bresnahan M, Strominger J, Spies T. Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. Proc Natl Acad Sci U S A. 1991;88:10094-8 pubmed
    ..A previously described peptide supply factor (PSF1) is a member of the multidrug-resistance family of transporters and may pump cytosolic peptides into the membrane-..
  2. Einstein M, Leanza S, Chiu L, Schlecht N, Goldberg G, Steinberg B, et al. Genetic variants in TAP are associated with high-grade cervical neoplasia. Clin Cancer Res. 2009;15:1019-23 pubmed publisher
    The transporter associated with antigen processing (TAP) is essential in assembling MHC-I proteins...
  3. Jackson D, Capra J. TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility. Proc Natl Acad Sci U S A. 1993;90:11079-83 pubmed
    ..The recently described TAP (transporter associated with antigen processing) genes have been mapped approximately midway between DP and DQ...
  4. Furukawa H, Murata S, Yabe T, Shimbara N, Keicho N, Kashiwase K, et al. Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome. J Clin Invest. 1999;103:755-8 pubmed
    ..antigen (HLA) class I molecules on the cell surface depends on the heterodimer of the transporter associated with antigen processing 1 and 2 (TAP1 and TAP2), which transport peptides cleaved by proteasome to the class I ..
  5. Casp C, She J, McCormack W. Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo. Genes Immun. 2003;4:492-9 pubmed
    ..genetic association of vitiligo in Caucasian patients with an early age of onset with the transporter associated with antigen processing-1 (TAP1) gene...
  6. Colonna M, Bresnahan M, Bahram S, Strominger J, Spies T. Allelic variants of the human putative peptide transporter involved in antigen processing. Proc Natl Acad Sci U S A. 1992;89:3932-6 pubmed
    ..Among these, PSF1 and PSF2 encode subunits of a transporter, which presumably delivers cytosolic peptides across the endoplasmic ..
  7. Herget M, Kreissig N, Kolbe C, Scholz C, Tampe R, Abele R. Purification and reconstitution of the antigen transport complex TAP: a prerequisite for determination of peptide stoichiometry and ATP hydrolysis. J Biol Chem. 2009;284:33740-9 pubmed publisher
    The transporter associated with antigen processing (TAP) is an essential machine of the adaptive immune system that translocates antigenic peptides from the cytosol into the endoplasmic reticulum lumen for loading of major ..
  8. Kordi Tamandani D, Sobti R, Shekari M, Husseini S, Suri V. No association of TAP1 and TAP2 genes polymorphism with risk of cervical cancer in north Indian population. J Assist Reprod Genet. 2009;26:173-8 pubmed publisher
    b>Transporter associated with antigen processing (TAP), a member of the ATP-binding cassette transporter super family, is composed of two integral membrane proteins, TAP-1 and TAP-2...
  9. Verweij M, Koppers Lalic D, Loch S, Klauschies F, de la Salle H, Quinten E, et al. The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex. J Immunol. 2008;181:4894-907 pubmed
    ..changes of TAP required for the translocation of peptides into the endoplasmic reticulum, and 2) by targeting TAP1 and TAP2 for proteasomal degradation. At present, it is unknown whether UL49.5 interacts with TAP1, TAP2, or both...

More Information

Publications97

  1. Koch J, Guntrum R, Tampe R. The first N-terminal transmembrane helix of each subunit of the antigenic peptide transporter TAP is essential for independent tapasin binding. FEBS Lett. 2006;580:4091-6 pubmed
    ..We found that the N-terminal domains of human TAP1 and TAP2 can independently bind to tapasin, thus providing two separate loading platforms for PLC assembly...
  2. Koppers Lalic D, Reits E, Ressing M, Lipinska A, Abele R, Koch J, et al. Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Proc Natl Acad Sci U S A. 2005;102:5144-9 pubmed
    ..is the translocation of peptides from the cytoplasm into the endoplasmic reticulum by the transporter associated with antigen processing (TAP). Here, we identified the bovine herpesvirus 1-encoded UL49...
  3. Yu M, Huang C, Wu M, Wu J, Tsai F. Association of TAP2 gene polymorphisms in Chinese patients with rheumatoid arthritis. Clin Rheumatol. 2004;23:35-9 pubmed
    ..was to investigate the association between the polymorphism of transporters associated with antigen processing ( TAP1/TAP2) genes and rheumatoid arthritis in Chinese patients...
  4. Correa P, Molina J, Pinto L, Arcos Burgos M, Herrera M, Anaya J. TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. Ann Rheum Dis. 2003;62:363-5 pubmed
    To determine the influence of TAP1 and TAP2 alleles in northwestern Colombian patients with systemic lupus erythematosus (SLE).
  5. Zhang S, Chabod J, Penfornis A, Reviron D, Tiberghien P, Wendling D, et al. TAP1 and TAP2 gene polymorphism in rheumatoid arthritis in a population in eastern France. Eur J Immunogenet. 2002;29:241-9 pubmed
    The 'transporter associated with antigen processing' (TAP) gene products are involved in the processing of endogenous peptides that bind to class I molecules...
  6. Takeuchi K, Abe S, Masuda S, Yuta A, Majima Y, Sakakura Y. Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese population. Ann Otol Rhinol Laryngol. 2002;111:460-3 pubmed
    Gene products of TAP1 and TAP2 (transporters associated with antigen processing) are involved in antigen presentation. It has been reported that polymorphisms in the TAP1 gene are associated with atopy in Tunisians...
  7. Gaudet R, Wiley D. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. EMBO J. 2001;20:4964-72 pubmed
    The transporter associated with antigen processing (TAP) is an ABC transporter formed of two subunits, TAP1 and TAP2, each of which has an N-terminal membrane-spanning domain and a C-terminal ABC ATPase domain...
  8. Zhu X, Zhang Y, Wang Q, Wang F. Polymorphisms of TAP, LMP and HLA-DM genes in the Chinese. Chin Med J (Engl). 2000;113:372-5 pubmed
    To investigate the distribution of antigen-processing genes transporter associated with antigen processing (TAP), low molecular weight proteasome (LMP2) and HLA-DM in the Shanghai population and to explore the possible role of these genes ..
  9. Ghanem E, Fritzsche S, Al Balushi M, Hashem J, Ghuneim L, Thomer L, et al. The transporter associated with antigen processing (TAP) is active in a post-ER compartment. J Cell Sci. 2010;123:4271-9 pubmed publisher
    ..It is mediated by the transporter associated with antigen processing (TAP) protein, which binds to peptide-receptive MHC class I molecules to form the MHC class I ..
  10. Cerundolo V, Alexander J, Anderson K, Lamb C, Cresswell P, McMichael A, et al. Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature. 1990;345:449-52 pubmed
    ..5), but in the present case the genetic defect can be mapped within the MHC locus on human chromosome 6. ..
  11. Ahn K, Meyer T, Uebel S, Sempe P, Djaballah H, Yang Y, et al. Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. EMBO J. 1996;15:3247-55 pubmed
    ..Since neither purified nor induced ICP47 inhibited photocrosslinking of 8-azido-ATP to TAP1 and TAP2 it seems that ICP47 does not prevent ATP from binding to TAP...
  12. Kanagawa S, Morinobu A, Koshiba M, Kageyama G, Hayashi N, Yoshino S, et al. Association of the TAP2*Bky2 allele with presence of SS-A/Ro and other autoantibodies in Japanese patients with systemic lupus erythematosus. Lupus. 2003;12:258-65 pubmed
    We previously reported that a new allele of transporter associated with antigen processing (TAP) 2 gene, TAP2*Bky2 (Val577), was significantly increased in Japanese patients with Sjögren's syndrome (SS) and had a strong association with ..
  13. Chen M, Abele R, Tampe R. Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing. J Biol Chem. 2003;278:29686-92 pubmed
    The transporter associated with antigen processing (TAP) plays a key role in the adaptive immune response by pumping antigenic peptides into the endoplasmic reticulum for subsequent loading of major histocompatibility complex class I ..
  14. Rufer E, Leonhardt R, Knittler M. Molecular architecture of the TAP-associated MHC class I peptide-loading complex. J Immunol. 2007;179:5717-27 pubmed
    ..peptide-receptive MHC class I (MHC-I) and accessory chaperones to the N-terminal regions of the TAP subunits TAP1 and TAP2...
  15. Procko E, Raghuraman G, Wiley D, Raghavan M, Gaudet R. Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I. Immunol Cell Biol. 2005;83:475-82 pubmed
    ..exit from the endoplasmic reticulum (ER), MHC class I molecules transiently associate with the transporter associated with antigen processing (TAP1/TAP2) in an interaction that is bridged by tapasin...
  16. Koch J, Guntrum R, Heintke S, Kyritsis C, Tampe R. Functional dissection of the transmembrane domains of the transporter associated with antigen processing (TAP). J Biol Chem. 2004;279:10142-7 pubmed
    The transporter associated with antigen processing (TAP1/2) translocates cytosolic peptides of proteasomal degradation into the endoplasmic reticulum (ER) lumen...
  17. Oancea G, O Mara M, Bennett W, Tieleman D, Abele R, Tampe R. Structural arrangement of the transmission interface in the antigen ABC transport complex TAP. Proc Natl Acad Sci U S A. 2009;106:5551-6 pubmed publisher
    The transporter associated with antigen processing (TAP) represents a focal point in the immune recognition of virally or malignantly transformed cells by translocating proteasomal degradation products into the endoplasmic reticulum-lumen ..
  18. Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. Nature. 1990;348:741-4 pubmed
    ..This superfamily includes the human multidrug-resistance protein, and a series of transporters from bacteria and eukaryotic cells capable of transporting a range of substrates, including peptides. ..
  19. Plewnia G, Schulze K, Hunte C, Tampe R, Koch J. Modulation of the antigenic peptide transporter TAP by recombinant antibodies binding to the last five residues of TAP1. J Mol Biol. 2007;369:95-107 pubmed
    The transporter associated with antigen processing (TAP) plays a pivotal role in the major histocompatibility complex (MHC) class I mediated immune response against infected or malignantly transformed cells...
  20. Alvarado Guerri R, Cabrera C, Garrido F, Lopez Nevot M. TAP1 and TAP2 polymorphisms and their linkage disequilibrium with HLA-DR, -DP, and -DQ in an eastern Andalusian population. Hum Immunol. 2005;66:921-30 pubmed
    b>Transporter associated with antigen processing (TAP) molecules are involved in the processing of endogenous peptides that bind to major histocompatibility complex (MHC) class I molecules...
  21. Lim E, Lim J, Kim E, Kim Y, Shin J, Seok P, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016;8: pubmed
    ..These data demonstrate that XB exhibits anti-diabetic, hypolipogenic, and anti-inflammatory effects via regulation of the miR-122a/33a axis in db/db mice. ..
  22. Dong P, Pan L, Zhang X, Zhang W, Wang X, Jiang M, et al. Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice. J Ethnopharmacol. 2017;198:479-488 pubmed publisher
  23. Ip B, Liu C, Lichtenstein A, von Lintig J, Wang X. Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice. J Nutr. 2015;145:268-76 pubmed publisher
    ..Sex disparity of BCO2-KO mice was observed in the outcomes of HSFD-induced liver steatosis and plasma lipids. ..
  24. Dorenbos R, Stein T, Kabel J, Bruand C, Bolhuis A, Bron S, et al. Thiol-disulfide oxidoreductases are essential for the production of the lantibiotic sublancin 168. J Biol Chem. 2002;277:16682-8 pubmed
    ..Notably BdbB cannot complement BdbC in competence development, showing that these two closely related thiol-disulfide oxidoreductases have different, but partly overlapping, substrate specificities...
  25. Kim H, Lee H, Lew B, Sim W, Kim Y, Lee S, et al. Association between TAP1 gene polymorphisms and alopecia areata in a Korean population. Genet Mol Res. 2015;14:18820-7 pubmed publisher
    The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways...
  26. Wang Y, Chen Z, Liao Y, Mei C, Peng H, Wang M, et al. Angiotensin II increases the cholesterol content of foam cells via down-regulating the expression of ATP-binding cassette transporter A1. Biochem Biophys Res Commun. 2007;353:650-4 pubmed
    ..2) The content of cholesterol was negatively correlated with ABCA1. The results suggest the promoting effects of AngII on the forming of foam cells are in a dose-dependent manner via down-regulating the expression of ABCA1...
  27. Ripperger A, Benndorf R. The C421A (Q141K) polymorphism enhances the 3'-untranslated region (3'-UTR)-dependent regulation of ATP-binding cassette transporter ABCG2. Biochem Pharmacol. 2016;104:139-47 pubmed publisher
    ..Moreover, tissue-specific variation in ABCG2 3'-UTR processing may profoundly affect ABCG2 expression levels in individuals carrying the C421A mutation. ..
  28. Xiao L, Zhang W, Jing T, Zhang M, Miao Z, Wei D, et al. Genome-wide identification, phylogenetic analysis, and expression profiles of ATP-binding cassette transporter genes in the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae). Comp Biochem Physiol Part D Genomics Proteomics. 2018;25:1-8 pubmed publisher
    ..dorsalis. These data suggest that ABC transporter genes might play key roles in xenobiotic metabolism and biosynthesis in B. dorsalis. ..
  29. Feng M, Yin B, Shen T, Huang H, Zheng J, Qian K, et al. Determination of TAP1 and TAP2 polymorphism in the Chinese Han population by real-time TaqMan polymerase chain reaction. Tissue Antigens. 2008;72:441-7 pubmed publisher
    The heterodimeric transporter associated with antigen processing (TAP) complex plays a key role in immune surveillance...
  30. Sukriti S, Pati N, Bose S, Hissar S, Sarin S. Impaired antigen processing and presentation machinery is associated with immunotolerant state in chronic hepatitis B virus infection. J Clin Immunol. 2010;30:419-25 pubmed publisher
    ..processing and transport to major histocompatibility complex class I molecules, namely due to low molecular weight protein (LMP) 2 and 7 and transporter associated with antigen processing (TAP) 1 and 2 genes could be playing a role.
  31. Yano H, Tamura Y, Kobayashi K, Tanemoto M, Uchida S. Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease. Clin Exp Nephrol. 2014;18:50-5 pubmed publisher
    ..We evaluated the expression of the UA transporter in the intestinal tract--the ATP-binding cassette transporter G2 (ABCG2)--in a 5/6 nephrectomy rat model of CKD...
  32. Kubitz R, Dröge C, Kluge S, Stross C, Walter N, Keitel V, et al. Autoimmune BSEP disease: disease recurrence after liver transplantation for progressive familial intrahepatic cholestasis. Clin Rev Allergy Immunol. 2015;48:273-84 pubmed publisher
    ..This review will summarize the current knowledge including diagnosis, pathomechanisms, and management of "autoimmune BSEP disease." ..
  33. Schmitz G, Grandl M. The molecular mechanisms of HDL and associated vesicular trafficking mechanisms to mediate cellular lipid homeostasis. Arterioscler Thromb Vasc Biol. 2009;29:1718-22 pubmed publisher
    ..This review summarizes the current knowledge of the molecular mechanisms of HDL and associated vesicular trafficking mechanisms to mediate cellular lipid homeostasis...
  34. Reimann S, Poschmann G, Kanonenberg K, Stühler K, Smits S, Schmitt L. Interdomain regulation of the ATPase activity of the ABC transporter haemolysin B from Escherichia coli. Biochem J. 2016;473:2471-83 pubmed publisher
    ..These results assign an interdomain regulatory role for the CLD modulating the hydrolytic activity of HlyB. ..
  35. Matschulla T, Berry R, Gerke C, Döring M, Busch J, Paijo J, et al. A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle. Sci Rep. 2017;7:2933 pubmed publisher
    The transporter associated with antigen processing (TAP) translocates antigenic peptides into the endoplasmic reticulum (ER) lumen for loading onto MHC class I molecules...
  36. Sui J, Mo Q, Li X, Ma J, Ren Y, Gao W, et al. [Transporter associated with antigen processing 1 637A/G gene polymorphisms and susceptibility to nasopharyngeal carcinoma in Han population in Yunnan Province, China]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010;45:238-43 pubmed
    To study the relationship between 637A/G gene polymorphisms of the transporter associated with antigen processing 1 gene and nasopharyngeal carcinomas (NPC) and to find out the susceptible genes of NPC in Han population in Yunnan Province,..
  37. Kockx M, Guo D, Traini M, Gaus K, Kay J, Wimmer Kleikamp S, et al. Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase 2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway. J Biol Chem. 2009;284:24144-54 pubmed publisher
    ..Taken together, these results establish a novel mechanism for the pro-atherosclerotic effects of CsA, and establish for the first time a role for PP2B in regulating the intracellular transport and secretion of apoE...
  38. Karasinska J, Rinninger F, Lutjohann D, Ruddle P, Franciosi S, Kruit J, et al. Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J Neurosci. 2009;29:3579-89 pubmed publisher
    ..Moreover, our findings also demonstrate that specific changes in brain cholesterol metabolism can lead to alterations in cholesterol uptake from plasma to brain...
  39. Francone O, Subbaiah P, Van Tol A, Royer L, Haghpassand M. Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Biochemistry. 2003;42:8569-78 pubmed
    ..Taken together, these observations suggest that ABCA1 is necessary for the adequate lipidation of apoAI, which enables the interaction with LCAT and subsequent maturation...
  40. Lin H, Tsai C, Tsai F, Chen W, Chen H, Fan S. Transporter associated with antigen processing gene 1 codon 333 and codon 637 polymorphisms are associated with primary open-angle glaucoma. Mol Diagn. 2004;8:245-52 pubmed
    ..In this study, we evaluated the association between primary open-angle glaucoma (POAG) and the transporter associated with antigen processing (TAP) gene polymorphisms...
  41. Asp L, Beraki S, Kristensson K, Ogren S, Karlsson H. Neonatal infection with neurotropic influenza A virus affects working memory and expression of type III Nrg1 in adult mice. Brain Behav Immun. 2009;23:733-41 pubmed publisher
    ..In addition to wild type mice, immunodeficient (Tap1(-/-)) mice lacking functional CD8(+) T cells, were included in the study to model the potential influence of a ..
  42. Kolovou V, Kolovou G, Marvaki A, Karakosta A, Vasilopoulos G, Kalogiani A, et al. ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses. Lipids Health Dis. 2011;10:56 pubmed publisher
    ..The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808 (R1587K)] and lipid profile in Greek young nurses...
  43. Lee J, Park Y, Koo S. ATP-binding cassette transporter A1 and HDL metabolism: effects of fatty acids. J Nutr Biochem. 2012;23:1-7 pubmed publisher
    ..Further studies are warranted to better understand the role of dietary fatty acids in HDL metabolism and their effects on cardiovascular health...
  44. Jonsson N, Klafke G, Corley S, Tidwell J, Berry C, Koh Tan H. Molecular biology of amitraz resistance in cattle ticks of the genus Rhipicephalus. Front Biosci (Landmark Ed). 2018;23:796-810 pubmed
  45. Narita S, Kanamaru K, Matsuyama S, Tokuda H. A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals. Mol Microbiol. 2003;49:167-77 pubmed
    ..Taken together, these results indicate that the mutation causes destabilization of the LolCDE complex and concomitantly prevents the accurate recognition of lipoprotein-sorting signals...
  46. Singh S, Mishra B. Major histocompatibility complex linked databases and prediction tools for designing vaccines. Hum Immunol. 2016;77:295-306 pubmed publisher
    ..predictions could be further improved by integrating proteasome cleavage (in conjugation with transporter associated with antigen processing (TAP) binding) prediction, as well as T cell receptor binding prediction...
  47. Zivanović B, Ullrich K, Steffens B, Spasić S, Galland P. The effect of auxin (indole-3-acetic acid) on the growth rate and tropism of the sporangiophore of Phycomyces blakesleeanus and identification of auxin-related genes. Protoplasma. 2018;255:1331-1347 pubmed publisher
    ..Our observations imply that IAA represents an intrinsic element of the sensory transduction of Phycomyces and that its mode of action must very likely differ in several respects from that operating in plants. ..
  48. Simone L, Wang X, Tuli A, McIlhaney M, Solheim J. Influence of the tapasin C terminus on the assembly of MHC class I allotypes. Immunogenetics. 2009;61:43-54 pubmed publisher
    ..domain disrupted K(d) folding and release from tapasin, but not interaction with transporter associated with antigen processing (TAP), indicating that the mechanism whereby the tapasin transmembrane/cytoplasmic domain ..
  49. Reddy S, Hama S, Ng C, Grijalva V, Navab M, Fogelman A. ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. Arterioscler Thromb Vasc Biol. 2002;22:1877-83 pubmed
    ..Therefore, we evaluated whether ABCA1 participates in LDL oxidation...
  50. Köhler S, Vahdati S, Scholz M, Wiese M. Structure activity relationships, multidrug resistance reversal and selectivity of heteroarylphenyl ABCG2 inhibitors. Eur J Med Chem. 2018;146:483-500 pubmed publisher
    ..1 μm. ..
  51. Selbo P, Weyergang A, Eng M, Bostad M, Mælandsmo G, Høgset A, et al. Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug. J Control Release. 2012;159:197-203 pubmed publisher
    ..This important findings warrant further development of the PCI technology as a strategy for efficient and site-specific eradication of MDR cells and CSC...
  52. Murano T, Yamaguchi T, Tatsuno I, Suzuki M, Noike H, Takanami T, et al. Subfraction analysis of circulating lipoproteins in a patient with Tangier disease due to a novel ABCA1 mutation. Clin Chim Acta. 2016;452:167-72 pubmed publisher
  53. Kabir I, Li Z, Bui H, Kuo M, Gao G, Jiang X. Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism. J Biol Chem. 2016;291:7651-60 pubmed publisher
    ..Importantly, small intestine Lpcat3 deficiency has a much bigger effect on plasma lipid levels than that of liver deficiency. Thus, inhibition of small intestine Lpcat3 might constitute a novel approach for treating hyperlipidemia. ..
  54. Ueno M, Itoh M, Sugihara K, Asano M, Takakura N. Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration. Blood. 2009;113:555-62 pubmed publisher
    ..Previously, we isolated a novel evolutionarily conserved DNA replication factor, PSF1 (partner of SLD5-1), from an HSC-specific cDNA library...
  55. Molday R. ATP-binding cassette transporter ABCA4: molecular properties and role in vision and macular degeneration. J Bioenerg Biomembr. 2007;39:507-17 pubmed
  56. Kobayashi Y, Sugiura T, Imajyo I, Shimoda M, Ishii K, Akimoto N, et al. Knockdown of the T-box transcription factor Brachyury increases sensitivity of adenoid cystic carcinoma cells to chemotherapy and radiation in vitro: implications for a new therapeutic principle. Int J Oncol. 2014;44:1107-17 pubmed publisher
    ..Therefore, Brachyury knockdown may be a useful therapeutic tool for sensitizing CSCs to conventional chemoradiotherapy...
  57. Yu X, Murao K, Imachi H, Li J, Nishiuchi T, Hosomi N, et al. Hyperglycemia suppresses ABCA1 expression in vascular smooth muscle cells. Horm Metab Res. 2010;42:241-6 pubmed publisher
    ..These results indicate that the glucose-induced suppression of ABCA1 expression is partially mediated by the activation of the p38-MAPK pathway...
  58. Peng F, Yang R. Prediction and analysis of three gene families related to leaf rust (Puccinia triticina) resistance in wheat (Triticum aestivum L.). BMC Plant Biol. 2017;17:108 pubmed publisher
    ..The genes containing nonsynonymous SNPs are promising candidates that can be investigated in future studies as potential new sources of leaf rust resistance in wheat breeding. ..
  59. Adorni M, Favari E, Ronda N, Granata A, Bellosta S, Arnaboldi L, et al. Free cholesterol alters macrophage morphology and mobility by an ABCA1 dependent mechanism. Atherosclerosis. 2011;215:70-6 pubmed publisher
    ..To investigate whether the morphological and functional changes typical of cell immobilization induced by free cholesterol (FC) accumulation in macrophages is related to the activity of the ATP-binding cassette transporter (ABCA1)...
  60. Davis W, Boyd J, Ile K, Tew K. Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. Biochim Biophys Acta. 2004;1683:89-100 pubmed
    ..Addition of progesterone or U18666A to CHO cells elevated ABCA2 expression. Finally, we found that ABCA2 expression was elevated in Niemann-Pick type C1 (NPC1) fibroblasts and in Familial Hypercholesterolemia (FHC) fibroblasts...
  61. Johnsen A, France J, Nagy N, Askew D, Abdul Karim F, Gerson S, et al. Systemic deficits in transporter for antigen presentation (TAP)-1 or proteasome subunit LMP2 have little or no effect on tumor incidence. Int J Cancer. 2001;91:366-72 pubmed
    ..have not revealed increased tumor incidence in mice with deficits in T-cell immunity, including mice lacking TAP1 (a subunit of the transporter for antigen presentation) or LMP2 (a regulated subunit of the 20S proteasome)...
  62. Beck S, Kelly A, Radley E, Khurshid F, Alderton R, Trowsdale J. DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. J Mol Biol. 1992;228:433-41 pubmed
    ..LMP7), thought to be involved in the proteolytic degradation of cytoplasmic antigens and two ABC transporter genes (TAP1 and TAP2), thought to be involved in pumping of the degraded peptides across the endoplasmic reticulum membrane...
  63. Henze U, Berger Bachi B. Penicillin-binding protein 4 overproduction increases beta-lactam resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 1996;40:2121-5 pubmed
    ..The role of the AbcA transporter in methicillin resistance remained unknown...
  64. Ikeda I, Kudo M, Hamada T, Nagao K, Oshiro Y, Kato M, et al. Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats. J Nutr Sci Vitaminol (Tokyo). 2009;55:252-6 pubmed
    ..These observations suggest that increased biliary excretion of cholesterol in SPI and HMF groups is caused by the enhanced expression of Abcg5/Abcg8...
  65. Evans D, Beil F. The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia. J Mol Med (Berl). 2003;81:264-70 pubmed
  66. Huwait E, Greenow K, Singh N, Ramji D. A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression. Cell Signal. 2011;23:542-9 pubmed publisher
    ..These studies reveal a novel role for JNK and PI3K/AKT signaling in the LXR-regulated expression in macrophages of several key genes implicated in atherosclerosis...
  67. Abe Dohmae S, Ikeda Y, Matsuo M, Hayashi M, Okuhira K, Ueda K, et al. Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. J Biol Chem. 2004;279:604-11 pubmed
    ..The data indicated that human ABCA7 would compensate the function of ABCA1 for release of cell cholesterol in a certain condition(s), but post-transcriptional regulation of their activity is different...
  68. Clee S, Zwinderman A, Engert J, Zwarts K, Molhuizen H, Roomp K, et al. Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Circulation. 2001;103:1198-205 pubmed
    ..However, the extent to which common variation within this gene influences plasma lipid levels and CAD in the general population is unknown...
  69. Buchmann J, Meyer C, Neschen S, Augustin R, Schmolz K, Kluge R, et al. Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity. Endocrinology. 2007;148:1561-73 pubmed
    ..01). Our data indicate a previously unrecognized role of ABCG1 in the regulation of energy balance and triglyceride storage...
  70. Setiadi A, David M, Seipp R, Hartikainen J, Gopaul R, Jefferies W. Epigenetic control of the immune escape mechanisms in malignant carcinomas. Mol Cell Biol. 2007;27:7886-94 pubmed
    Downregulation of the transporter associated with antigen processing 1 (TAP-1) has been observed in many tumors and is closely associated with tumor immunoevasion mechanisms, growth, and metastatic ability...
  71. Aquino Galvez A, Camarena A, Montaño M, Juarez A, Zamora A, Gonzalez Avila G, et al. Transporter associated with antigen processing (TAP) 1 gene polymorphisms in patients with hypersensitivity pneumonitis. Exp Mol Pathol. 2008;84:173-7 pubmed publisher
    ..The distribution of single nucleotide polymorphisms (SNPs) in TAP1 genes was analyzed in 73 hypersensitivity pneumonitis (HP) patients and 58 normal subjects...
  72. Strader L, Monroe Augustus M, Rogers K, Lin G, Bartel B. Arabidopsis iba response5 suppressors separate responses to various hormones. Genetics. 2008;180:2019-31 pubmed publisher
  73. Chen Y, Li M, Islam I, You L, Wang Y, Li Z, et al. Allelic-specific expression in relation to Bombyx mori resistance to Bt toxin. Insect Biochem Mol Biol. 2014;54:53-60 pubmed publisher
    ..The potential role of allelic-specific gene regulation in insect resistance to Bt toxins is discussed. ..
  74. Ning Y, Ren S, Zhao F, Yin L. Overexpression of the steroidogenic acute regulatory protein increases the expression of ATP-binding cassette transporters in microvascular endothelial cells (bEnd.3). J Zhejiang Univ Sci B. 2010;11:350-6 pubmed publisher
    ..3)...
  75. Oram J, Vaughan A, Stocker R. ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol. J Biol Chem. 2001;276:39898-902 pubmed
    ..These studies provide evidence that ABCA1 mediates secretion of cellular alpha-TOH into the HDL metabolic pathway, a process that may facilitate vitamin transport between tissues and influence lipid oxidation...
  76. Woebking B, Velamakanni S, Federici L, Seeger M, Murakami S, van Veen H. Functional role of transmembrane helix 6 in drug binding and transport by the ABC transporter MsbA. Biochemistry. 2008;47:10904-14 pubmed publisher
    ..This study demonstrates for the first time the significance of TMH 6 for drug binding and transport by MsbA. Based on these data, a possible mechanism for alternating access of drug-binding surfaces in MsbA is discussed...
  77. Hang L, Hsia T, Chen W, Chen H, Tsai F. TAP1 gene AccI polymorphism is associated with atopic bronchial asthma. J Clin Lab Anal. 2003;17:57-60 pubmed
    ..A transporter associated with the antigen processing 1 gene (TAP1) is involved in antigen processing, and is therefore considered to play a role in the pathogenesis of bronchial ..
  78. Dugan G, Hewitt E. Dependence of the localization and function of the human cytomegalovirus protein US6 on the transporter associated with antigen processing. J Gen Virol. 2009;90:2234-8 pubmed publisher
    Human cytomegalovirus protein US6 inhibits the transporter associated with antigen processing (TAP), which transports peptides into the endoplasmic reticulum (ER) for binding to major histocompatibility complex (MHC) class I molecules...
  79. Guo Z, Wang Q, Lai W, Zha Z, Liu Y, Wu P. [A novel polymorphism in the ATP-binding cassette transporter A1 gene (M233V) in Chinese patients with coronary artery disease]. Zhonghua Xin Xue Guan Bing Za Zhi. 2006;34:1101-4 pubmed
    ..To identify ATP-binding cassette transporter A1 (ABCA1) gene polymorphism in Chinese patients with coronary artery disease (CAD)...
  80. Kato M, Ito Y, Tanaka Y, Sato M, Imaizumi K, Inoue N, et al. SHRSP/Izm and WKY/NCrlCrlj rats having a missense mutation in Abcg5 deposited plant sterols in the body, but did not change their biliary secretion and lymphatic absorption-comparison with Jcl:Wistar and WKY/Izm rats. Biosci Biotechnol Biochem. 2012;76:660-4 pubmed
    ..Our observations suggest that plant sterol deposition in rat strains with the missense mutation in Abcg5 cDNA can occur, despite there being no significant change in the biliary secretion or lymphatic absorption of plant sterols...
  81. Sunder S, Hanumanth S, Gaddam S, Jonnalagada S, Valluri V. Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus-tuberculosis co-infection. Hum Immunol. 2011;72:908-11 pubmed publisher
    ..I binding peptides are carried from cytosol to the lumen of the endoplasmic reticulum (ER) by transporter associated with antigen processing (TAP), an integral ER membrane protein composed of two subunits, TAP1 and TAP2...
  82. Huang S, Chen R, Wan L, Tsai F, Chen W. TAP 2 gene Msp-I polymorphism might be associated with calcium oxalate stone disease. Urol Int. 2005;75:264-8 pubmed
    ..Our aim was to investigate the relationship between stone disease and 5 polymorphic sites of the TAP gene (TAP1-1, 1-2, 2-1, 2-2, 2-3).
  83. Lewis R, Shroyer N, Singh N, Allikmets R, Hutchinson A, Li Y, et al. Genotype/Phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease. Am J Hum Genet. 1999;64:422-34 pubmed
    ..These findings support the hypothesis that compound heterozygous ABCR mutations are responsible for STGD1 and that some heterozygous ABCR mutations may enhance susceptibility to AMD...
  84. Ishikawa T, Kajimoto Y, Inoue Y, Ikegami Y, Kuroiwa T. Critical role of ABCG2 in ALA-photodynamic diagnosis and therapy of human brain tumor. Adv Cancer Res. 2015;125:197-216 pubmed publisher
    ..In this context, it is of great interest to develop ABCG2 inhibitors that can be applied to PDD or PDT for the therapy of brain tumor and other tumors. ..
  85. Hotta N, Abe Dohmae S, Taguchi R, Yokoyama S. Preferential incorporation of shorter and less unsaturated acyl phospholipids into high density lipoprotein-like particles in the ABCA1- and ABCA7-mediated biogenesis with apoA-I. Chem Phys Lipids. 2015;187:1-9 pubmed publisher
    ..The results are consistent with the view that assembly of HDL particles with extracellular apoA-I is primarily with the cellular phospholipid molecules being regulated in part by their physicochemical nature. ..
  86. Wang M, Franklin V, Marcel Y. In vivo reverse cholesterol transport from macrophages lacking ABCA1 expression is impaired. Arterioscler Thromb Vasc Biol. 2007;27:1837-42 pubmed
    ..However, it is yet to be established that the ABCA1 effect is related to specific changes in RCT from the macrophages in vivo...
  87. Li Q, Wei X, Yin R. Association of ATP binding cassette transporter G8 rs4148217 SNP and serum lipid levels in Mulao and Han nationalities. Lipids Health Dis. 2012;11:46 pubmed publisher
    ..Mulao nationality is an isolated minority in China. The aim of this study was to evaluate the association of ABCG8 rs4148217 SNP and several environmental factors with serum lipid levels in the Guangxi Mulao and Han populations...
  88. Kage K, Fujita T, Sugimoto Y. Role of Cys-603 in dimer/oligomer formation of the breast cancer resistance protein BCRP/ABCG2. Cancer Sci. 2005;96:866-72 pubmed
    ..Our findings suggest that Cys-603 is an important residue in the covalent bridge between BCRP monomers but that a functioning unit of BCRP may not necessarily require covalent linkages...