Gene Symbol: TANGO
Description: MIA family member 3, ER export factor
Alias: ARNT, D320, TANGO, TANGO1, UNQ6077, transport and Golgi organization protein 1 homolog, C219-reactive peptide, melanoma inhibitory activity family, member 3, melanoma inhibitory activity protein 3, transport and Golgi organization protein 1
Species: human
Products:     TANGO

Top Publications

  1. McKeown P, Merlini P, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009;41:334-41 pubmed publisher
    ..SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with myocardial infarction risk. ..
  2. Saito K, Yamashiro K, Ichikawa Y, Erlmann P, Kontani K, Malhotra V, et al. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. Mol Biol Cell. 2011;22:2301-8 pubmed publisher
    ..In addition, cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII, by the interaction of their coiled-coil motifs...
  3. Saito K, Chen M, Bard F, Chen S, Zhou H, Woodley D, et al. TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites. Cell. 2009;136:891-902 pubmed publisher
    ..We now provide evidence that one of these proteins, TANGO1, is an integral membrane protein localized to endoplasmic reticulum (ER) exit sites, with a luminal SH3 domain and ..
  4. Engin A. Human Protein Kinases and Obesity. Adv Exp Med Biol. 2017;960:111-134 pubmed publisher
    ..monophosphate (AMP)-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR), N-terminal Per-ARNT-Sim (PAS) kinase are nutrient responsive protein kinases and important for proper regulation of glucose metabolism ..
  5. Bogacz A, Bartkowiak Wieczorek J, Mikołajczak P, Rakowska Mrozikiewicz B, Grzeskowiak E, Wolski H, et al. The influence of soybean extract on the expression level of selected drug transporters, transcription factors and cytochrome P450 genes encoding phase I drug-metabolizing enzymes. Ginekol Pol. 2014;85:348-53 pubmed
    ..Moreove, we also showed a slight decrease in the amount of mRNA for CAR, PXR and ARNT after 3 days...
  6. Harkitis P, Daskalopoulos E, Malliou F, Lang M, Marselos M, Fotopoulos A, et al. Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver. PLoS ONE. 2015;10:e0128708 pubmed publisher
    ..The expression of AhR, heat shock protein 90 (HSP90) and AhR nuclear translocator (ARNT) was suppressed by SULP in B[a]P-treated livers, whereas the AhRR expression was increased by the drug suggesting ..
  7. Pérez García A, Dongil P, Hurtado Carneiro V, Blazquez E, Sanz C, Alvarez E. High-fat diet alters PAS kinase regulation by fasting and feeding in liver. J Nutr Biochem. 2018;57:14-25 pubmed publisher
    ..Per-Arnt-Sim (PAS) kinase (PASK) controls glucose homeostasis and energy metabolism in response to nutritional status...
  8. Engin A. Circadian Rhythms in Diet-Induced Obesity. Adv Exp Med Biol. 2017;960:19-52 pubmed publisher
    ..peroxisome proliferator-activated receptor (PPAR) alpha increases the transcriptional level of brain and muscle ARNT-like 1 (BMAL1) in obese subjects...
  9. Lehnert K, Weirup L, Harding K, Harkonen T, Karlsson O, Teilmann J. Antarctic seals: Molecular biomarkers as indicators for pollutant exposure, health effects and diet. Sci Total Environ. 2017;599-600:1693-1704 pubmed publisher
    ..of xenobiotic biomarkers (aryl hydrocarbon receptor (AHR)), aryl hydrocarbon receptor nuclear translocator (ARNT) and peroxisome proliferator-activated receptor (PPAR?) and immune relevant cell mediators (cytokines interleukin-2 ..

More Information


  1. Cai Y, Pan L, Miao J, Liu T. Identification of interacting proteins with aryl hydrocarbon receptor in scallop Chlamys farreri by yeast two hybrid screening. Ecotoxicol Environ Saf. 2016;133:381-9 pubmed publisher
    The aryl hydrocarbon receptor (AhR) belongs to the basic-helix-loop helix (bHLH) Per-Arnt-Sim (PAS) family of transcription factors...
  2. Luyts K, Smulders S, Napierska D, Van Kerckhoven S, Poels K, Scheers H, et al. Pulmonary and hemostatic toxicity of multi-walled carbon nanotubes and zinc oxide nanoparticles after pulmonary exposure in Bmal1 knockout mice. Part Fibre Toxicol. 2014;11:61 pubmed publisher
    ..We used Bmal1 (brain and muscle ARNT-like protein-1) knockout (Bmal1(-/-)) mice which have a disturbed circadian rhythm and procoagulant phenotype, to ..
  3. Guo R, Pan L, Lin P, Zheng L. The detoxification responses, damage effects and bioaccumulation in the scallop Chlamys farreri exposed to single and mixtures of benzo[a]pyrene and chrysene. Comp Biochem Physiol C Toxicol Pharmacol. 2017;191:36-51 pubmed publisher
    ..Heat shock protein 90 (HSP90) and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA expression was significantly elevated at days 1, 10 and 15...
  4. Hill A, Heiden T, Heideman W, Peterson R. Potential roles of Arnt2 in zebrafish larval development. Zebrafish. 2009;6:79-91 pubmed publisher
    The aryl hydrocarbon receptor nuclear translocator (ARNT) is a basic helix-loop-helix-PAS heterodimeric transcription factor that dimerizes with other basic helix-loop-helix-PAS proteins to mediate biological responses...
  5. Righetti B, Mattos J, Siebert M, Daura Jorge F, Bezamat C, Fruet P, et al. Biochemical and molecular biomarkers in integument biopsies of free-ranging coastal bottlenose dolphins from southern Brazil. Chemosphere. 2019;225:139-149 pubmed publisher
    ..also quantified, as were the mRNA transcript levels of aryl hydrocarbon receptor (AhR), AhR nuclear translocator (ARNT), cytochrome P450 1A1-like (CYP1A1), metallothionein 2A (MT2A), GST-π, GPx-4, GR, interleukin 1 alpha (IL-1α), ..
  6. Faust D, Nikolova T, Wätjen W, Kaina B, Dietrich C. The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation. Arch Toxicol. 2017;91:967-982 pubmed publisher
    ..The antioxidant response factor Nrf2 was not activated following ICZ. Functional inhibition of the AhR and AhR-/ARNT-defective cell lines demonstrate that the AhR/ARNT pathway is mandatory for the observed ROS defence caused by ICZ, ..
  7. Kurita H, Schnekenburger M, Ovesen J, Xia Y, Puga A. The Ah receptor recruits IKK? to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation. Toxicol Sci. 2014;139:121-32 pubmed publisher
    ..Following activation and nuclear translocation, AHR heterodimerizes with the AHR nuclear translocator (ARNT) and binds to AHR response elements (AhREs) in the enhancer of target genes, of which Cyp1a1 is the prototype...
  8. Gilbert J, De Iuliis G, Tarleton M, McCluskey A, Sakoff J. (Z)-2-(3,4-Dichlorophenyl)-3-(1H-Pyrrol-2-yl)Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway. Mol Pharmacol. 2018;93:168-177 pubmed publisher
    ..For the first time, we identify (Z)-2-(3,4-dichlorophenyl)-3-(1H-pyrrol-2-yl)acrylonitrile as a new AhR ligand. ..
  9. Felgner S, Frahm M, Kocijancic D, Rohde M, Eckweiler D, Bielecka A, et al. aroA-Deficient Salmonella enterica Serovar Typhimurium Is More Than a Metabolically Attenuated Mutant. MBio. 2016;7: pubmed publisher
    ..deletion of aroA affected flagellin phase variation and gene expression of the virulence-associated genes arnT and ansB Finally, ?aroA strains displayed significantly improved tumor therapeutic activity...
  10. Honscha W, Dötsch K, Thomsen N, Petzinger E. Cloning and functional characterization of the bile acid-sensitive methotrexate carrier from rat liver cells. Hepatology. 2000;31:1296-304 pubmed
    ..Both cDNAs contain the binding site sequence for the dioxin/nuclear translocator responsive element (Ah/Arnt-receptor) in conjunction with a barbiturate recognition sequence (Barbie box)...
  11. Cai Y, Pan L, Miao J. Molecular evidence for the existence of an aryl hydrocarbon receptor pathway in scallops Chlamys farreri. Comp Biochem Physiol B Biochem Mol Biol. 2016;196-197:74-84 pubmed publisher
    ..of the residues and domains essential to the function of AhR, including basic helix-loop-helix (bHLH) and Per-ARNT-Sim (PAS) domains. Phylogenetic analysis demonstrated that it was clustered within the invertebrate AhR branch...
  12. Charron C, Dawson H, Albaugh G, Solverson P, Vinyard B, Solano Aguilar G, et al. A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans. J Nutr. 2015;145:2448-55 pubmed publisher
    ..be upregulated by garlic intake: aryl hydrocarbon receptor (AHR), aryl hydrocarbon receptor nuclear translocator (ARNT), hypoxia-inducible factor 1α (HIF1A), proto-oncogene c-Jun (JUN), nuclear factor of activated T cells (NFAT) ..
  13. Zimmermann C, Stévant I, Borel C, Conne B, Pitetti J, Calvel P, et al. Research resource: the dynamic transcriptional profile of sertoli cells during the progression of spermatogenesis. Mol Endocrinol. 2015;29:627-42 pubmed publisher
    ..endothelial PAS domain-containing protein 1 (EPAS1/Hif2α), aryl hydrocarbon receptor nuclear translocator (ARNT/Hif1β), and signal transducer and activator of transcription 1 (STAT1) as potential master regulators driving ..
  14. Wang W, Yin L, Bai L, Ma G, Zhao C, Xiang A, et al. Bmal1 interference impairs hormone synthesis and promotes apoptosis in porcine granulosa cells. Theriogenology. 2017;99:63-68 pubmed publisher
    ..In current study, we investigated the role of the key circadian clock gene, brain and muscle arnt-like protein-1 (Bmal1), on porcine granulosa cell hormone secretion and apoptosis...
  15. Huang Y, Zhu Z, Xie M, Xue J. Involvement of adenosine monophosphate-activated protein kinase in the influence of timed high-fat evening diet on the hepatic clock and lipogenic gene expression in mice. Nutr Res. 2015;35:792-9 pubmed publisher
    ..Accordingly, the hepatic clock genes, including clock, brain-muscle-Arnt-like 1, cryptochrome 2, and period 2, exhibited prominent changes in their expression rhythms and/or amplitudes...
  16. Beesley S, Lee J, Olcese J. Circadian clock regulation of melatonin MTNR1B receptor expression in human myometrial smooth muscle cells. Mol Hum Reprod. 2015;21:662-71 pubmed publisher
    ..examined the binding of the clock gene product brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like protein 1 (BMAL1) to the promoter of the hMTNR1B gene...
  17. Nikodemova M, Yee J, Carney P, Bradfield C, Malecki K. Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. Environ Int. 2018;113:249-258 pubmed publisher
    ..genes (GADD45A, DDB2, RAD51 and P53), two oxidative stress genes (FTH1, TXN), two hypoxia response genes (BN1P3lL, ARNT), and one gene associated with unfolded protein response (ATF6B)...
  18. Dittmann K, Rothmund M, Paasch A, Mayer C, Fehrenbacher B, Schaller M, et al. The nuclear aryl hydocarbon receptor is involved in regulation of DNA repair and cell survival following treatment with ionizing radiation. Toxicol Lett. 2016;240:122-9 pubmed publisher
    ..Knockdown of the co-activator ARNT, which is essential for transcriptional activation of AhR target genes, reduced AhR-dependent CYP1A expression in ..
  19. Mendiola M, Redondo A, Heredia Soto V, Herranz J, Berjón A, Hernandez A, et al. Predicting Response to Standard First-line Treatment in High-grade Serous Ovarian Carcinoma by Angiogenesis-related Genes. Anticancer Res. 2018;38:5393-5400 pubmed publisher
    ..Univariate analysis identified five genes [angiopoietin 1 (ANGPT1), aryl hydrocarbon receptor nuclear translocator (ARNT), CD34, epidermal growth factor (EGF) and matrix metallopeptidase 3 (MMP3)] as being statistically associated with ..
  20. Breit A, Miek L, Schredelseker J, Geibel M, Merrow M, Gudermann T. Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. J Biol Chem. 2018;293:17278-17290 pubmed publisher
    Brain and muscle ARNT-like protein-1 (BMAL-1) is an important component of the cellular circadian clock...
  21. Hwang H, Dornbos P, Steidemann M, Dunivin T, Rizzo M, LaPres J. Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol. 2016;304:121-32 pubmed publisher
    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor within the Per-Arnt-Sim (PAS) domain superfamily...
  22. Lidral A, Liu H, Bullard S, Bonde G, Machida J, Visel A, et al. A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1. Hum Mol Genet. 2015;24:3895-907 pubmed publisher
    ..7 kb element containing rs7850258 allele G is significantly more responsive to both MYC and ARNT than allele A...
  23. Ichihara S, Li P, Mise N, Suzuki Y, Izuoka K, Nakajima T, et al. Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling. Arch Toxicol. 2019;: pubmed publisher
    ..receptor (AHR) is a transcription factor that binds to DNA as a heterodimer with the AHR nuclear translocator (ARNT) after interaction with ligands, such as polycyclic and halogenated aromatic hydrocarbons and other xenobiotics...
  24. Wada T, Ichihashi Y, Suzuki E, Kosuge Y, Ishige K, Uchiyama T, et al. Deletion of Bmal1 Prevents Diet-Induced Ectopic Fat Accumulation by Controlling Oxidative Capacity in the Skeletal Muscle. Int J Mol Sci. 2018;19: pubmed publisher
    Brain and muscle arnt-like protein 1 (BMAL1), is a transcription factor known to regulate circadian rhythm. BMAL1 was originally characterized by its high expression in the skeletal muscle...
  25. Ekemen S, Uzay A, Başsüllü N, Dikicioğlu Çetin E, Matsuda K, Ince U, et al. Does it take three to tango? An unsuspected multimorbidity of CD8+ T cell lymphoproliferative disorder, malaria, and EBV infection. Malar J. 2018;17:349 pubmed publisher
    ..Notably, Plasmodium infection should be examined in patients from malaria endemic regions by pathological and molecular investigations. ..
  26. Ferlic P, Mannion A, Jeszenszky D, Porchet F, Fekete T, Kleinstück F, et al. Patient-reported outcome of surgical treatment for lumbar spinal epidural lipomatosis. Spine J. 2016;16:1333-1341 pubmed publisher
    ..and from our local Spine Surgery Outcomes Database, which we operate in connection with the International Spine Tango Registry...
  27. Zhang D, Zhang J, Wang Y, Liu Y, Liu G, Li X. Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism. Nutrients. 2015;7:7437-50 pubmed publisher
    Per-Arnt-Sim Kinase (PASK) is an evolutionarily-conserved nutrient-responsive protein kinase that regulates lipid and glucose metabolism, mitochondrial respiration, phosphorylation, and gene expression...
  28. Furukawa Hibi Y, Nagai T, Yun J, Yamada K. Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene. Neuroreport. 2015;26:827-32 pubmed publisher
    Neuronal Per Arnt Sim domain 4 (Npas4), a brain-specific helix-loop-helix transcription factor, was recently shown to regulate the development of GABAergic inhibitory neurons...
  29. Smit E, Souza T, Jennen D, Kleinjans J, van den Beucken T. Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics. Toxicology. 2017;390:74-82 pubmed publisher
    ..Finally, knock-down of ARNT reduced ?-H2AX in response to BaP, which was associated with reduced CYP1A1 expression...
  30. Semplici F, Mondragon A, Macintyre B, Madeyski Bengston K, Persson Kry A, Barr S, et al. Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production. Diabetologia. 2016;59:1938-47 pubmed publisher
    Per-Arnt-Sim kinase (PASK) is a nutrient-regulated domain-containing protein kinase previously implicated in the control of insulin gene expression and glucagon secretion...
  31. Talari N, Panigrahi M, Madigubba S, Phanithi P. Overexpression of aryl hydrocarbon receptor (AHR) signalling pathway in human meningioma. J Neurooncol. 2018;137:241-248 pubmed publisher
    ..We report the up regulation of AHR pathway genes like aryl hydrocarbon receptor nuclear translocator (ARNT), aldehyde dehydrogenase1family memberA3 (ALDH1A3), cytochrome P450, family1, subfamily A polypeptide1 (CYP1A1) and ..
  32. Girer N, Murray I, Omiecinski C, Perdew G. Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression. J Biol Chem. 2016;291:15378-87 pubmed publisher
    ..Using EMSA, we demonstrate that the AHR-ARNT heterodimer binds to a specific DRE that overlaps binding sequences for peroxisome proliferator-activated receptor ?..
  33. Gardella K, Muro I, Fang G, Sarkar K, Mendez O, Wright C. Aryl hydrocarbon receptor nuclear translocator (ARNT) isoforms control lymphoid cancer cell proliferation through differentially regulating tumor suppressor p53 activity. Oncotarget. 2016;7:10710-22 pubmed publisher
    The aryl hydrocarbon receptor nuclear translocator (ARNT) is involved in xenobiotic and hypoxic responses, and we previously showed that ARNT also regulates nuclear factor-κB (NF-κB) signaling by altering the DNA binding activity of ..
  34. Nakashima K, Ogiwara T, Hirai T, Tanaka T, Murata H, Kaburagi K, et al. Gerontoxanthone B from Maclura cochinchinensis var. gerontogea exhibits anti-inflammatory potential as an aryl hydrocarbon receptor agonist. Bioorg Med Chem. 2017;25:4253-4258 pubmed publisher
    ..receptor (AhR) is a ligand-dependent transcriptional factor belonging to the basic helix-loop-helix-Per-Ahr/Arnt-Sim family. In this study, we evaluated the AhR agonistic activities of 12 xanthones isolated from the roots of M...
  35. Joshi A, Hossain E, Elferink C. Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein 2 Selectively Induces Stanniocalcin 2 Expression. Mol Pharmacol. 2017;92:366-374 pubmed publisher
    ..depends on its binding to the xenobiotic response element (XRE) in partnership with the AhR nuclear translocator (Arnt)...
  36. Rojas Pirela M, Rigden D, Michels P, Cáceres A, Concepcion J, Quiñones W. Structure and function of Per-ARNT-Sim domains and their possible role in the life-cycle biology of Trypanosoma cruzi. Mol Biochem Parasitol. 2018;219:52-66 pubmed publisher
    Per-ARNT-Sim (PAS) domains of proteins play important roles as modules for signalling and cellular regulation processes in widely diverse organisms such as Archaea, Bacteria, protists, plants, yeasts, insects and vertebrates...
  37. Hanieh H, Mohafez O, Hairul Islam V, Alzahrani A, Bani Ismail M, Thirugnanasambantham K. Novel Aryl Hydrocarbon Receptor Agonist Suppresses Migration and Invasion of Breast Cancer Cells. PLoS ONE. 2016;11:e0167650 pubmed publisher
    ..It induces formation of Ahr/Ahr nuclear translocator (Arnt) heterodimer to promote the expression of cytochrome P450 family 1 subfamily A member 1 (Cyp1a1)...
  38. Ma W, Goldberg J. TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats. Proc Natl Acad Sci U S A. 2016;113:10061-6 pubmed publisher
    ..coat protein complex II (COPII)-coated carriers at endoplasmic reticulum (ER) exit sites by the receptor molecule TANGO1/cTAGE5...
  39. Wang Z, Gu H, Yang F, Xie H, Sheng L, Li M. [Intramuscular injection of lentivirus-mediated EPAS1 gene improves hind limb ischemia and its mechanism in a rat model of peripheral artery vascular disease]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1539-1543 pubmed
    Objective To investigate the effect of over-expressed endothelial Per-Arnt-Sim domain protein 1 (EPAS1) on peripheral arterial disease (PAD) in a rat model...
  40. Tavares Carreón F, Fathy Mohamed Y, Andrade A, Valvano M. ArnT proteins that catalyze the glycosylation of lipopolysaccharide share common features with bacterial N-oligosaccharyltransferases. Glycobiology. 2016;26:286-300 pubmed publisher
    b>ArnT is a glycosyltransferase that catalyzes the addition of 4-amino-4-deoxy-l-arabinose (l-Ara4N) to the lipid A moiety of the lipopolysaccharide...
  41. Dumbell R, Leliavski A, Matveeva O, Blaum C, Tsang A, Oster H. Dissociation of Molecular and Endocrine Circadian Rhythms in Male Mice Lacking Bmal1 in the Adrenal Cortex. Endocrinology. 2016;157:4222-4233 pubmed
    ..to be important coordinators of glucocorticoid release and loss of the core clock component Brain and muscle Arnt-like protein-1 leads to ablation of behavioral and physiological rhythms, hypocortisolism, impaired ACTH, and ..
  42. Hunter S, Vonk A, Mullen Grey A, Riddick D. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Drug Metab Dispos. 2017;45:118-129 pubmed publisher
    The aryl hydrocarbon receptor (AHR) nuclear translocator (ARNT), as the AHR's heterodimerization partner, and NADPH-cytochrome P450 oxidoreductase (POR), as the key electron donor for all microsomal P450s, are independent and ..
  43. Sullivan A, Peet D, Whitelaw M. MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors. FEBS J. 2016;283:3488-502 pubmed publisher
    Transcription factors of the basic helix-loop-helix (bHLH) PER-ARNT-SIM (PAS) family generally have critical and nonredundant biological roles, but some bHLH PAS proteins compete for common cofactors or recognise similar DNA elements...
  44. Højgaard K, Christiansen S, Bouzinova E, Wiborg O. Disturbances of diurnal phase markers, behavior, and clock genes in a rat model of depression; modulatory effects of agomelatine treatment. Psychopharmacology (Berl). 2018;235:627-640 pubmed publisher
    ..histochemistry to measure the expression levels of the core clock genes, period (Per) 1 and 2 and bone and muscle ARNT-like protein 1 (Bmal1), in multiple brain regions believed to be implicated in depression...
  45. Gabel C, Cuesta Vargas A, Qian M, Vengust R, Berlemann U, Aghayev E, et al. The Oswestry Disability Index, confirmatory factor analysis in a sample of 35,263 verifies a one-factor structure but practicality issues remain. Eur Spine J. 2017;26:2007-2013 pubmed publisher
    ..Analysis of pooled baseline ODI LBP patient data from the international Spine Tango registry of EUROSPINE, the Spine Society of Europe. The sample, with n = 35,263 (55...
  46. Momma T, Okayama H, Saitou M, Sugeno H, Yoshimoto N, Takebayashi Y, et al. Expression of circadian clock genes in human colorectal adenoma and carcinoma. Oncol Lett. 2017;14:5319-5325 pubmed publisher
    ..2, cryptochrome 1 (Cry1), circadian locomoter output cycles protein kaput (Clock), brain and muscle ARNT-like protein 1 (Bmal1) and casein kinase 1? (CK1?) were retrospectively examined in 51 cases of ..
  47. Lefta M, Campbell K, Feng H, Jin J, Esser K. Development of dilated cardiomyopathy in Bmal1-deficient mice. Am J Physiol Heart Circ Physiol. 2012;303:H475-85 pubmed publisher
    ..Mice lacking the core circadian clock gene, brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like protein (Bmal1), are behaviorally arrhythmic, die prematurely, and display a wide range of organ pathologies...
  48. Abendroth J, Frando A, Phan I, Staker B, Myler P, Edwards T, et al. Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein. Protein Sci. 2017;: pubmed publisher
    ..that combines one cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA (GAF) domain and two Per-ARNT-Sim (PAS) domains. GAF and PAS domains are typically sensor domains that are linked to signaling effector molecules...
  49. Poniah P, Mohd Zain S, Abdul Razack A, Kuppusamy S, Karuppayah S, Sian Eng H, et al. Genome-wide copy number analysis reveals candidate gene loci that confer susceptibility to high-grade prostate cancer. Urol Oncol. 2017;35:545.e1-545.e11 pubmed publisher
    ..The CNV gain regions were 1q21.3, 15q15, 7p12.1, and a novel CNV in PCa 12q23.1, harboring ARNT, THBS1, SLC5A8, and DDC genes that are crucial in the p53 and cancer pathways...
  50. Min H, Kim K, Wee G, Kim E, Jang W. Bmal1 induces osteoblast differentiation via regulation of BMP2 expression in MC3T3-E1 cells. Life Sci. 2016;162:41-6 pubmed publisher
    Mammalian circadian rhythms regulate many metabolic processes. Recent studies suggest that brain and muscle Arnt-like 1 (BMAL1), an important component of mammalian circadian rhythm, is associated with insulin signaling...
  51. Sobottke R, Herren C, Siewe J, Mannion A, Röder C, Aghayev E. Predictors of improvement in quality of life and pain relief in lumbar spinal stenosis relative to patient age: a study based on the Spine Tango registry. Eur Spine J. 2017;26:462-472 pubmed publisher
    ..The study was performed on the basis of Spine Tango registry data. The database query resulted in 4768 patients from 40 international Spine Tango centres...
  52. Kleinstueck F, Fekete T, Jeszenszky D, Haschtmann D, Mannion A. Adult degenerative scoliosis: comparison of patient-rated outcome after three different surgical treatments. Eur Spine J. 2016;25:2649-56 pubmed publisher
    ..Our local spine surgery database (part of the Eurospine Spine Tango Registry) was used to acquire the data from patients with ADS undergoing D, SF or LF...
  53. Talay M, Richman E, Snell N, Hartmann G, Fisher J, Sorkaç A, et al. Transsynaptic Mapping of Second-Order Taste Neurons in Flies by trans-Tango. Neuron. 2017;96:783-795.e4 pubmed publisher
    ..Here we describe trans-Tango, a technique for anterograde transsynaptic circuit tracing and manipulation...
  54. Skallerup P, Nejsum P, Jørgensen C, Goring H, Karlskov Mortensen P, Archibald A, et al. Detection of a quantitative trait locus associated with resistance to Ascaris suum infection in pigs. Int J Parasitol. 2012;42:383-91 pubmed
    ..001) and adult worm burden(P < 0.0001), whereas the other SNP (ARNT) was associated with adult worm burden (P < 0.025) in these populations...
  55. Bressler J, Folsom A, Couper D, Volcik K, Boerwinkle E. Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study. Am J Epidemiol. 2010;171:14-23 pubmed publisher
    ..This study demonstrates that genetic variants revealed in a case-control genome-wide association study enriched for early disease onset may play a role in the genetic etiology of CHD in the general population. ..
  56. Pillai R, Paglialunga S, Hoang M, Cousteils K, Prentice K, Bombardier E, et al. Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo. Diabetologia. 2015;58:2832-42 pubmed publisher
    It has been suggested that the transcription factor ARNT/HIF1β is critical for maintaining in vivo glucose homeostasis and pancreatic beta cell glucose-stimulated insulin secretion (GSIS)...
  57. Lesne E, Krammer E, Dupre E, Locht C, Lensink M, Antoine R, et al. Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella. MBio. 2016;7:e02089 pubmed publisher
    ..Following its transmembrane segment, BvgS harbors a cytoplasmic Per-Arnt-Sim (PAS) domain and then a predicted 2-helix coiled coil that precede the dimerization-histidine-phosphotransfer ..
  58. Santos A, Nogueira C, Ortega Bellido M, Malhotra V. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. J Cell Biol. 2016;213:343-54 pubmed publisher
    ..vesicles, so how are these bulky cargoes exported from the endoplasmic reticulum (ER)? We have shown that TANGO1 located at the ER exit site is necessary for procollagen export...
  59. Xue T, Song C, Wang Q, Wang Y, Chen G. Investigations of the CLOCK and BMAL1 Proteins Binding to DNA: A Molecular Dynamics Simulation Study. PLoS ONE. 2016;11:e0155105 pubmed publisher
    The circadian locomotor output cycles kaput (CLOCK), and brain and muscle ARNT-like 1 (BMAL1) proteins are important transcriptional factors of the endogenous circadian clock...
  60. Zajda K, Ptak A, Rak A, Fiedor E, Grochowalski A, Milewicz T, et al. Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines. Toxicology. 2017;389:1-12 pubmed publisher
    ..mixtures on the expression of the aryl hydrocarbon receptor (AHR), aryl hydrocarbon receptor nuclear translocator (ARNT) and aryl hydrocarbon receptor repressor (AHRR) genes, as well as the expression and activity of target genes ..
  61. Mouralidarane A, Soeda J, Sugden D, Bocianowska A, Carter R, Ray S, et al. Maternal obesity programs offspring non-alcoholic fatty liver disease through disruption of 24-h rhythms in mice. Int J Obes (Lond). 2015;39:1339-48 pubmed publisher
    ..We demonstrate hypermethylation of BMAL-1 (brain and muscle Arnt like-1) and Per2 promoter regions and altered 24-h rhythmicity of hepatic pro-inflammatory and fibrogenic mediators...
  62. Sun D, Zheng Q, Zhang H. Molecular dynamics investigation of stereoselective inhibition mechanism of HIF-2?/ARNT heterodimer. J Mol Recognit. 2017;: pubmed publisher
    ..the binding of ligand A (S, R)-24 begets the significant conformation changes of ?-sheets and interrupts the HIF-2?/ARNT heterodimerization, which may be attributed to the disruption of the hydrogen bond and salt bridge interactions ..
  63. Adler E, Corona R, Lee J, Rodriguez Malave N, Mhawech Fauceglia P, Sowter H, et al. The PAX8 cistrome in epithelial ovarian cancer. Oncotarget. 2017;8:108316-108332 pubmed publisher
    ..that PAX8 binding sites overlapping superenhancers or enhancers, but not promoters, were enriched for JUND/B and ARNT/AHR motifs...
  64. Polonikov A, Bushueva O, Bulgakova I, Freidin M, Churnosov M, Solodilova M, et al. A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility. Pharmacogenet Genomics. 2017;27:57-69 pubmed publisher
    ..We found that SNP rs2228099 of ARNT is associated with an increased risk of EH (odds ratio=1.20 95% confidence interval: 1.01-1.44, P=0...
  65. Weisenburger S, Boening D, Schomburg B, Giller K, Becker S, Griesinger C, et al. Cryogenic optical localization provides 3D protein structure data with Angstrom resolution. Nat Methods. 2017;14:141-144 pubmed publisher
    ..We demonstrate COLD by determining the conformational state of the cytosolic Per-ARNT-Sim domain from the histidine kinase CitA of Geobacillus thermodenitrificans and resolving the four biotin sites of ..
  66. Zheng Y, Xie J, Huang X, Dong J, Park M, Chan W. Binding studies using Pichia pastoris expressed human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins. Protein Expr Purif. 2016;122:72-81 pubmed publisher
    ..enhancer as the heterodimer, which is consisted of AHR and the aryl hydrocarbon receptor nuclear translocator (ARNT)...
  67. Mori H, Yao Y, Learman B, Kurozumi K, Ishida J, Ramakrishnan S, et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016;6:21520 pubmed publisher
    ..With hypoxia, the stabilized HIF-α and aryl hydrocarbon receptor nuclear translocator (ARNT, also known as HIF-β) heterodimer bind to hypoxia response elements (HREs) and regulate expression of target ..
  68. Lesne E, Dupré E, Lensink M, Locht C, Antoine R, Jacob Dubuisson F. Coiled-Coil Antagonism Regulates Activity of Venus Flytrap-Domain-Containing Sensor Kinases of the BvgS Family. MBio. 2018;9: pubmed publisher
    ..In BvgS, helical linkers connect periplasmic Venus flytrap (VFT) perception domains to a cytoplasmic Per-Arnt-Sim (PAS) domain and the PAS domain to the dimerization/histidine phosphotransfer (DHp) domain of the kinase...
  69. Yang M, Lin P, Hsiao H, Hsu J, Lin H, Hsu C, et al. Up-regulation of PER3 Expression Is Correlated with Better Clinical Outcome in Acute Leukemia. Anticancer Res. 2015;35:6615-22 pubmed
    ..cryptochrome 1 (CRY1), cryptochrome 2 (CRY2), brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like 1 (BMAL1), and timeless (TIM) was significantly down-regulated, while that of CK1ε was significantly up-..
  70. Lee H, Nah S, Chang S, Kim H, Kwon J, Lee S, et al. PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility. Mol Med Rep. 2017;16:422-428 pubmed publisher
    ..The mammalian clock genes, which include circadian locomotor output cycles kaput, brain and muscle Arnt-like protein 1, period and cryptochrome, regulate circadian rhythms...
  71. Fala A, Oliveira J, Adamoski D, Aricetti J, Dias M, Dias M, et al. Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. Sci Rep. 2015;5:12698 pubmed publisher
  72. Bock K. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-mediated deregulation of myeloid and sebaceous gland stem/progenitor cell homeostasis. Arch Toxicol. 2017;91:2295-2301 pubmed publisher
    ..receptor (AHR), a multifunctional, ligand-activated transcription factor of the basic helix-loop-helix/Per-Arnt-Sim family...
  73. Cui H, Gu X, Chen J, Xie Y, Ke S, Wu J, et al. Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[?]-pyrene-induced DNA damage. Toxicol Lett. 2017;275:67-76 pubmed publisher
    ..We have utilized three well-characterized cell lines, i.e. Hepa1c1c7, AhR +/+; Bpr lacks AhR obligatory partner ARNT; Tao, lacks AhR, to analyze pivotal role of AhR/ARNT complex in mediating the BaP-induced DNA damages using comet ..
  74. Jiang L, Shi S, Shi Q, Zhang H, Hu R, Wang M. Similarity in the functions of HIF-1? and HIF-2? proteins in cervical cancer cells. Oncol Lett. 2017;14:5643-5651 pubmed publisher
    ..Hypoxia inducible factor (HIF)-1, composed of a constitutively expressed ?-subunit (HIF-?/ARNT) and one of the three known oxygen-regulated ?-subunits, HIF-1?, HIF-2?, or HIF-3?, mediates the tumour cell ..
  75. Sadowska A, Paukszto L, Nynca A, Szczerbal I, Orlowska K, Swigonska S, et al. Transcript variations, phylogenetic tree and chromosomal localization of porcine aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) genes. J Genet. 2017;96:75-85 pubmed
    ..AhR requires aryl hydrocarbon receptor nuclear translocator (ARNT) to form an active transcription complex and promote the activation of genes which have dioxin responsive element ..
  76. Ko H. In science communication, why does the idea of a public deficit always return? How do the shifting information flows in healthcare affect the deficit model of science communication?. Public Underst Sci. 2016;25:427-32 pubmed publisher
    ..Given the many stakeholders dancing together in a multidirectional tango of communication, we need to ask how much does the deficit model apply to the health field? History dictates that ..
  77. Tafiadis D, Kosma E, Chronopoulos S, Papadopoulos A, Toki E, Vassiliki S, et al. Acoustic and Perceived Measurements Certifying Tango as Voice Treatment Method. J Voice. 2018;32:256.e13-256.e24 pubmed publisher
    ..This study was designed to examine the effect of tango on adult acoustic voice parameters...
  78. Betti C, Schymkowitz J, Rousseau F, Russinova E. Selective Knockdowns in Maize by Sequence-Specific Protein Aggregation. Methods Mol Biol. 2018;1676:109-127 pubmed publisher
    ..The presence of APRs in a target protein can be predicted by a dedicated algorithm, such as TANGO. Synthetic aggregation-prone proteins are designed by expressing specific APRs fused to a fluorescent carrier for ..
  79. Konieczka P, Smulikowska S. Viscosity negatively affects the nutritional value of blue lupin seeds for broilers. Animal. 2017;:1-10 pubmed publisher
    ..reference lupin-free diet and 10 test diets containing one of five lupin seeds; Kadryl, Regent, Dalbor, Bojar and Tango, mixed with the reference diet at a ratio of 25 : 75 or 32 : 68 dry matter (DM) (low or high level of inclusion) ..
  80. Tang X, Shao J, Qin X. Crystal structure of the PAS domain of the hEAG potassium channel. Acta Crystallogr F Struct Biol Commun. 2016;72:578-85 pubmed publisher
    ..The cytoplasmic parts of the subunits present a Per-Arnt-Sim (PAS) domain at the N-terminus and a cyclic nucleotide-binding homology domain at the C-terminus...
  81. Zehnder P, Aghayev E, Fekete T, Haschtmann D, Pigott T, Mannion A. Influence of previous surgery on patient-rated outcome after surgery for degenerative disorders of the lumbar spine. Eur Spine J. 2016;25:2553-62 pubmed publisher
    ..The study included 4940 patients with lumbar degenerative disease documented in the Spine Tango Registry of EUROSPINE, the Spine Society of Europe, from 2004 to 2015...
  82. Lee J, Tokumoto M, Hwang G, Lee M, Satoh M. Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity. Sci Rep. 2017;7:17287 pubmed publisher
    ..In this study, we demonstrated that Cd decreased the activity of the ARNT transcription factor, and knockdown of ARNT significantly decreased the viability of human proximal tubular HK-2 ..
  83. Li S, Zhai J, Liu J, Hong Y, Zhao W, Zhao A, et al. BMAL1 facilitates trophoblast migration and invasion via SP1-DNMT1/DAB2IP pathway in recurrent spontaneous abortion. Oncotarget. 2017;8:89451-89464 pubmed publisher
    ..Brain and muscle ARNT-like protein 1 (BMAL1) is considered as a crucial role in fertility, and polymorphism of BMAL1 gene has been ..
  84. Badin P, Sopariwala D, Lorca S, Narkar V. Muscle Arnt/Hif1? Is Dispensable in Myofiber Type Determination, Vascularization and Insulin Sensitivity. PLoS ONE. 2016;11:e0168457 pubmed publisher
    Aryl Hydrocarbon Receptor Nuclear Translocator/ hypoxia-inducible factor 1 beta (ARNT/ HIF1?), a member of bHLH-PAS family of transcriptional factors, plays a critical role in metabolic homeostasis, insulin resistance and glucose ..
  85. Militi S, Maywood E, Sandate C, Chesham J, Barnard A, Parsons M, et al. Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking. Proc Natl Acad Sci U S A. 2016;113:2756-61 pubmed publisher
    ..We describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutation, early doors (Edo), in the PER-ARNT-SIM (PAS) domain dimerization region of period 2 (PER2) (I324N) that accelerates the circadian clock of Per2(Edo/..
  86. Liu Y, Machuca M, Beckham S, Gunzburg M, Roujeinikova A. Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains. Acta Crystallogr D Biol Crystallogr. 2015;71:2127-36 pubmed publisher
    ..crystallographic analysis of the structure and ligand-induced conformational changes of the periplasmic tandem Per-Arnt-Sim (PAS) sensing domain (PTPSD) of a characterized MCP chemoreceptor...