Talin

Summary

Gene Symbol: Talin
Description: talin 1
Alias: ILWEQ, TLN, talin-1, talin-1
Species: human
Products:     Talin

Top Publications

  1. Defilippi P, Di Stefano P, Cabodi S. p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol. 2006;16:257-63 pubmed
    ..Here, we discuss recent developments that highlight a fundamental role in cell transformation and microbial pathogenesis and the implications of these developments on p130Cas function under normal and pathological conditions. ..
  2. Moes M, Rodius S, Coleman S, Monkley S, Goormaghtigh E, Tremuth L, et al. The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton. J Biol Chem. 2007;282:17280-8 pubmed
    ..protein that links integrins to actin filaments through two distinct integrin binding sites, one present in the talin head domain (IBS1) necessary for integrin activation and a second (IBS2) that we have previously mapped to talin ..
  3. Chen H, Appeddu P, Parsons J, Hildebrand J, Schaller M, Guan J. Interaction of focal adhesion kinase with cytoskeletal protein talin. J Biol Chem. 1995;270:16995-9 pubmed
    ..3, 258-262). Here, we report data suggesting a possible association of FAK with the cytoskeletal protein talin in NIH 3T3 cells...
  4. Humphries J, Wang P, Streuli C, Geiger B, Humphries M, Ballestrem C. Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol. 2007;179:1043-57 pubmed
    ..sites in the head and tail regions induces dramatic FA growth, which is mediated by their direct interaction with talin. This interaction leads to clustering of activated integrin and an increase in integrin residency time in FAs...
  5. Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg M. Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol. 2009;11:624-30 pubmed publisher
    ..b>Talin, an actin and beta-integrin tail-binding protein, is essential for integrin activation and focal adhesion ..
  6. Sakamoto S, McCann R, Dhir R, Kyprianou N. Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance. Cancer Res. 2010;70:1885-95 pubmed publisher
  7. Critchley D. Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion. Biochem Soc Trans. 2004;32:831-6 pubmed
    The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix...
  8. Calderwood D, Yan B, de Pereda J, Alvarez B, Fujioka Y, Liddington R, et al. The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem. 2002;277:21749-58 pubmed
    ..The head domain of talin binds to several integrin beta tails and activates integrins...
  9. Giannone G, Jiang G, Sutton D, Critchley D, Sheetz M. Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J Cell Biol. 2003;163:409-19 pubmed
    ..Thus, force-dependent activation of tyrosine kinases is independent of early force-dependent structural changes that require talin1 as part of a critical scaffold. ..

More Information

Publications139 found, 100 shown here

  1. Salgia R, Li J, Lo S, Brunkhorst B, Kansas G, Sobhany E, et al. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. J Biol Chem. 1995;270:5039-47 pubmed
    ..The predicted structure of paxillin implicates this molecule in protein-protein interactions involved in signal transduction from growth factor receptors and the BCR/ABL oncogene fusion protein to the cytoskeleton. ..
  2. Martel V, Racaud Sultan C, Dupe S, Marie C, Paulhe F, Galmiche A, et al. Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J Biol Chem. 2001;276:21217-27 pubmed
    b>Talin is a structural component of focal adhesion sites and is thought to be engaged in multiple protein interactions at the cytoplasmic face of cell/matrix contacts...
  3. Ling K, Doughman R, Firestone A, Bunce M, Anderson R. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature. 2002;420:89-93 pubmed
    ..regulates interactions between these proteins, including the interaction of vinculin with actin and talin. The binding of talin to beta-integrin is strengthened by PtdIns(4,5)P(2), suggesting that the basis of focal ..
  4. Tremuth L, Kreis S, Melchior C, Hoebeke J, Ronde P, Plançon S, et al. A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain. J Biol Chem. 2004;279:22258-66 pubmed
    The cytoskeletal protein talin, which provides a direct link between integrins and actin filaments, has been shown to contain two distinct binding sites for integrin beta subunits...
  5. Elliott P, Goult B, Kopp P, Bate N, Grossmann J, Roberts G, et al. The Structure of the talin head reveals a novel extended conformation of the FERM domain. Structure. 2010;18:1289-99 pubmed publisher
    ..The crystal structure of the N-terminal head of the integrin-associated cytoskeletal protein talin reported here reveals a novel FERM domain with a linear domain arrangement, plus an additional domain F0 packed ..
  6. Bass M, Smith B, Prigent S, Critchley D. Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix. Biochem J. 1999;341 ( Pt 2):257-63 pubmed
    Using recombinant talin polypeptides and an SDS/PAGE-blot overlay assay, we have previously identified three regions of talin that are involved in binding to vinculin [Gilmore, Wood, Ohanian, Jackson, Patel, Rees, Hynes and Critchley (..
  7. Cohen D, Chen H, Johnson R, Choudhury B, Craig S. Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin. J Biol Chem. 2005;280:17109-17 pubmed
    Vinculin is autoinhibited by an intramolecular interaction that masks binding sites for talin and F-actin...
  8. Beaty B, Wang Y, Bravo Cordero J, Sharma V, Miskolci V, Hodgson L, et al. Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis. J Cell Biol. 2014;205:737-51 pubmed publisher
    ..The role of the focal adhesion protein talin in regulating these structures is not known...
  9. Senetar M, Foster S, McCann R. Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin. Biochemistry. 2004;43:15418-28 pubmed
    ..I/LWEQ module proteins include the metazoan talins, the cellular slime mold talin homologues TalA and TalB, fungal Sla2p, and the metazoan Sla2 homologues Hip1 and Hip12 (Hip1R)...
  10. Patel B, Gingras A, Bobkov A, Fujimoto L, Zhang M, Liddington R, et al. The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod. J Biol Chem. 2006;281:7458-67 pubmed
    The talin rod contains approximately 11 vinculin binding sites (VBSs), each defined by hydrophobic residues in a series of amphipathic helices that are normally buried within the helical bundles that make up the rod...
  11. Kanamori H, Kawakami T, Effendi K, Yamazaki K, Mori T, Ebinuma H, et al. Identification by differential tissue proteome analysis of talin-1 as a novel molecular marker of progression of hepatocellular carcinoma. Oncology. 2011;80:406-15 pubmed publisher
    ..tandem mass spectrometry data from those peptide peaks identified 61 proteins, including a cytoskeletal protein, talin-1, as upregulated in HCC...
  12. Huang Y, Zhang X, Jiang W, Wang Y, Jin H, Liu X, et al. Discovery of serum biomarkers implicated in the onset and progression of serous ovarian cancer in a rat model using iTRAQ technique. Eur J Obstet Gynecol Reprod Biol. 2012;165:96-103 pubmed publisher
    ..These proteins could be used as diagnostic biomarkers for early detection, disease monitoring and therapeutic targets. ..
  13. Li W, Hu N, Wang Z, Yu K, Su H, Wang L, et al. Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population. PLoS ONE. 2013;8:e68999 pubmed publisher
    ..05). Our data suggest an association between specific genes in the EGFR signaling pathway and risk of GC and ESCC. Further studies are warranted to validate these associations and to investigate underlying mechanisms. ..
  14. Kang W, Kim S, Cho H, Jin J, Lee J, Joo K, et al. Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme. Oncotarget. 2015;6:27239-51 pubmed publisher
    ..These data implicate TLN1 as a novel therapeutic target for GBM to overcome resistance to anti-angiogenic therapies. ..
  15. van de Klundert M, van den Biggelaar M, Kootstra N, Zaaijer H. Hepatitis B Virus Protein X Induces Degradation of Talin-1. Viruses. 2016;8: pubmed
    ..To identify such host proteins, we systematically analyzed the HBx interactome. One HBx interacting protein, talin-1 (TLN1), was proteasomally degraded upon HBx expression...
  16. Jevnikar Z, Obermajer N, Doljak B, Turk S, Gobec S, Svajger U, et al. Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells. J Leukoc Biol. 2011;90:99-109 pubmed publisher
    ..C-terminal amino acids from the ?(2) cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form...
  17. Law D, Nannizzi Alaimo L, Phillips D. Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem. 1996;271:10811-5 pubmed
    ..The data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin. ..
  18. Zhu F, Zhuang Y, Wu B, Li J, He B. Rational Substitution of Surface Acidic Residues for Enhancing the Thermostability of Thermolysin. Appl Biochem Biotechnol. 2016;178:725-38 pubmed publisher
    ..dynamic (MD) simulation was performed to analyze two surface acidic residues (Asp37 and Glu119) of thermolysin (TLN) in mediating its thermostability...
  19. Haage A, Goodwin K, Whitewood A, Camp D, Bogutz A, Turner C, et al. Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo. Cell Rep. 2018;25:2401-2416.e5 pubmed publisher
    ..Integrin adhesion receptors bind ECM ligands outside the cell and then, by binding the protein talin inside the cell, assemble an adhesion complex connecting to the cytoskeleton...
  20. Geng L, Burrow C, Li H, Wilson P. Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation. Biochim Biophys Acta. 2000;1535:21-35 pubmed
    ..analyses and in vitro binding assays have shown that polycystin-1 associates with the focal adhesion proteins talin, vinculin, p130Cas, FAK, alpha-actinin, paxillin and pp60c-src in subconfluent normal human fetal collecting ..
  21. Liyan L, Si W, Qian W, Yuhui S, Xiaoer W, Yuehua L, et al. Diffusion Kurtosis as an in vivo Imaging Marker of Early Radiation-Induced Changes in Radiation-Induced Temporal Lobe Necrosis in Nasopharyngeal Carcinoma Patients. Clin Neuroradiol. 2018;28:413-420 pubmed publisher
    ..We explored the value of DKI for the early detection of radiation-induced changes in temporal lobe necrosis (TLN) after radiotherapy (RT) for nasopharyngeal carcinoma (NPC)...
  22. Wu L, Chung Y. Tumor-Infiltrating T Cell Receptor-Beta Repertoires are Linked to the Risk of Late Chemoradiation-Induced Temporal Lobe Necrosis in Locally Advanced Nasopharyngeal Carcinoma. Int J Radiat Oncol Biol Phys. 2019;104:165-176 pubmed publisher
    Temporal lobe necrosis (TLN), a late complication of nasopharyngeal carcinoma (NPC) after concurrent chemoradiotherapy (CCRT), causes permanent neurologic deficits...
  23. Manevich E, Grabovsky V, Feigelson S, Alon R. Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. J Biol Chem. 2007;282:25338-48 pubmed
    ..b>Talin 1 maintained VLA-4 in a high affinity conformation, thereby promoting rapid VLA-4 adhesion strengthening to VCAM-1 ..
  24. Hirata H, Tatsumi H, Lim C, Sokabe M. Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions. Am J Physiol Cell Physiol. 2014;306:C607-20 pubmed publisher
    ..cytoskeleton is anchored to the extracellular matrix through integrin and a variety of linker proteins including talin and vinculin. The localization of vinculin at FAs depends on mechanical forces...
  25. Liu J, Wang Y, Goh W, Goh H, Baird M, Ruehland S, et al. Talin determines the nanoscale architecture of focal adhesions. Proc Natl Acad Sci U S A. 2015;112:E4864-73 pubmed publisher
    ..We demonstrate that talin plays a key structural role in regulating the nanoscale architecture of FAs, akin to a molecular ruler...
  26. Sun N, Critchley D, Paulin D, Li Z, Robson R. Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin. Exp Cell Res. 2008;314:1839-49 pubmed publisher
    ..Costameres are multi-protein assemblies enriched in the cytoskeletal proteins vinculin, alpha-actinin, and talin. We report herein a direct interaction of human alpha-synemin with the cytoskeletal protein talin by protein-..
  27. Xu Y, Ren X, Li Y, He Q, Tang X, Sun Y, et al. High expression of Talin-1 is associated with poor prognosis in patients with nasopharyngeal carcinoma. BMC Cancer. 2015;15:332 pubmed publisher
    b>Talin-1 is a cytoskeletal protein that plays an important role in tumourgenesis, migration and metastasis in several malignant tumors...
  28. Klann J, Remedios K, Kim S, Metz P, Lopez J, Mack L, et al. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 2017;198:4639-4651 pubmed publisher
    b>Talin, a cytoskeletal protein essential in mediating integrin activation, has been previously shown to be involved in the regulation of T cell proliferation and function...
  29. Khan M, Dedachi K, Matsui T, Kurita N, Borgatti M, Gambari R, et al. Dipeptide inhibitors of thermolysin and angiotensin I-converting enzyme. Curr Top Med Chem. 2012;12:1748-62 pubmed
    Thermolysin (TLN) and other thermolysin-like zinc metalloproteinases (TLPs),are important virulence factors for pathogenesis of bacterial infections by suppressing the innate immune system of the host...
  30. Bois P, Borgon R, Vonrhein C, Izard T. Structural dynamics of alpha-actinin-vinculin interactions. Mol Cell Biol. 2005;25:6112-22 pubmed
    ..association with vinculin's tail domain and which differ from the alterations in Vh1 provoked by the binding of talin. Surprisingly, alphaVBS binds to Vh1 in an inverted orientation compared to the binding of talin's VBSs to ..
  31. Teja A, Musmade P, Khade A, Dengale S. Simultaneous improvement of solubility and permeability by fabricating binary glassy materials of Talinolol with Naringin: Solid state characterization, in-vivo in-situ evaluation. Eur J Pharm Sci. 2015;78:234-44 pubmed publisher
    The aim of the current study was to prepare binary amorphous forms of Talinolol (TLN) by using Naringin (NRG) as a stabilizing agent...
  32. Alimba C, Bakare A. In vivo micronucleus test in the assessment of cytogenotoxicity of landfill leachates in three animal models from various ecological habitats. Ecotoxicology. 2016;25:310-9 pubmed publisher
    ..NAs occurred in the order; BN > BL > LB > NT in the catfish and BN > BudN > TLN > TN in quail...
  33. Li J, Ghatak S, El Masry M, Das A, Liu Y, Roy S, et al. Topical Lyophilized Targeted Lipid Nanoparticles in the Restoration of Skin Barrier Function following Burn Wound. Mol Ther. 2018;26:2178-2188 pubmed publisher
    Lyophilized keratinocyte-targeted nanocarriers (TLNκ) loaded with locked nucleic acid (LNA) modified anti-miR were developed for topical application to full thickness burn injury...
  34. Luo D, Zhan S, Xia W, Huang L, Ge W, Wang T. Proteomics study of serum exosomes from papillary thyroid cancer patients. Endocr Relat Cancer. 2018;25:879-891 pubmed publisher
    ..In the serum exosomes of PTC patients with LNM, integrin-associated proteins are obviously upregulated. These proteomic findings will contribute to elucidation of the pathophysiological functions of tumour-derived exosomes. ..
  35. Domadia P, Li Y, Bhunia A, Mohanram H, Tan S, Bhattacharjya S. Functional and structural characterization of the talin F0F1 domain. Biochem Biophys Res Commun. 2010;391:159-65 pubmed publisher
    The globular head domain of talin, a large multi-domain cytoplasmic protein, is required for inside-out activation of the integrins, a family of heterodimeric transmembrane cell adhesion molecules...
  36. Curto C, Geneson J, Morrison K. Fixed Points of Competitive Threshold-Linear Networks. Neural Comput. 2019;31:94-155 pubmed publisher
    ..The fixed points of a TLN, including both stable and unstable equilibria, play a critical role in shaping its emergent dynamics...
  37. Smith A, Carrasco Y, Stanley P, Kieffer N, Batista F, Hogg N. A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. J Cell Biol. 2005;170:141-51 pubmed
    ..b>Talin is essential for the stability and formation of the LFA-1 zone...
  38. Kalli A, Sansom M. Interactions of peripheral proteins with model membranes as viewed by molecular dynamics simulations. Biochem Soc Trans. 2014;42:1418-24 pubmed publisher
  39. Wang X, Ying H, He X, Zhou Z, Wu Y, Hu C. Treatment of cerebral radiation necrosis with nerve growth factor: A prospective, randomized, controlled phase II study. Radiother Oncol. 2016;120:69-75 pubmed publisher
    ..to test the efficacy of Nerve Growth Factor (NGF) for the treatment of symptomatic temporal lobe necrosis (TLN). Patients with progressive TLN were randomly assigned to either the control or the study group in a 1:1 ratio...
  40. Wei X, Sun Y, Wu Y, Zhu J, Gao B, Yan H, et al. Downregulation of Talin-1 expression associates with increased proliferation and migration of vascular smooth muscle cells in aortic dissection. BMC Cardiovasc Disord. 2017;17:162 pubmed publisher
    This study aimed to assessed whether Talin-1 is involved in the pathogenesis of aortic dissection via regulating vascular smooth muscle cell (VSMC) biological function...
  41. Bromberger T, Klapproth S, Rohwedder I, Zhu L, Mittmann L, Reichel C, et al. Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice. Blood. 2018;: pubmed publisher
  42. Lagarrigue F, Kim C, Ginsberg M. The Rap1-RIAM-talin axis of integrin activation and blood cell function. Blood. 2016;128:479-87 pubmed publisher
    ..We discuss how talin binding to the integrin ? cytoplasmic domain, in conjunction with the plasma membrane, induces long-range ..
  43. Soslau G, Mason C, Lynch S, Benjamin J, Ashak D, Prakash J, et al. Intracellular matrix metalloproteinase-2 (MMP-2) regulates human platelet activation via hydrolysis of talin. Thromb Haemost. 2014;111:140-53 pubmed publisher
    ..MMP-2 functions intracellularly to regulate agonist-induced platelet aggregations via the hydrolytic activation of talin, the presumed final activating factor of glycoprotein (GP)IIb/IIIa integrin (the inside-out signal)...
  44. Nanda S, Hoang T, Patel P, Zhang H. Vinculin regulates assembly of talin: ?3 integrin complexes. J Cell Biochem. 2014;115:1206-16 pubmed publisher
    Vinculin is a talin-binding protein that promotes integrin-mediated cell adhesion, but the mechanisms are not understood...
  45. Alsebaey A, Ahmedy E. Talin-1 and Non-invasive Fibrosis Models in the Assessment of Patients with Hepatocellular Carcinoma. Asian Pac J Cancer Prev. 2016;17:4077-82 pubmed
    ..The aim was to assess the role of serum talin-1 and non-invasive brosis in patients with HCC...
  46. Li X, Sun Y, Huang S, Chen Y, Chen X, Li M, et al. Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway. EBioMedicine. 2019;39:69-82 pubmed publisher
    ..Inhibition of AZIN2-sv induced angiogenesis and myocardial regeneration simultaneously, thus, AZIN2-sv could be an ideal therapeutic target for improving myocardial repair after MI. FUND: National Natural Science Foundations of China. ..
  47. Bouvard D, Vignoud L, Dupe Manet S, Abed N, Fournier H, Vincent Monegat C, et al. Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha. J Biol Chem. 2003;278:6567-74 pubmed
    ..adhesions, which may result from the ability of ICAP-1 alpha to inhibit the association of beta(1A) integrin with talin, which is crucial for the assembly of these structures...
  48. Anastasi G, Cutroneo G, Gaeta R, Di Mauro D, Arco A, Consolo A, et al. Dystrophin-glycoprotein complex and vinculin-talin-integrin system in human adult cardiac muscle. Int J Mol Med. 2009;23:149-59 pubmed
    ..and they appear to comprise two protein complexes, the dystrophin-glycoprotein complex (DGC) and the vinculin-talin-integrin system...
  49. Moulik M, Vatta M, Witt S, Arola A, Murphy R, McKenna W, et al. ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol. 2009;54:325-33 pubmed publisher
    ..The M184I mutation results in loss of CARP binding with Talin 1 and FHL2, and the P105S mutation in loss of Talin 1 binding...
  50. Pelchen Matthews A, Giese S, Mlcochova P, Turner J, Marsh M. ?2 integrin adhesion complexes maintain the integrity of HIV-1 assembly compartments in primary macrophages. Traffic. 2012;13:273-91 pubmed publisher
    ..is clustered at these coated domains, and that the coats themselves contain the cytoskeletal linker proteins talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton...
  51. Tekeli İ, Atessahin A, Sakin F, Aslan A, Ceribasi S, Yipel M. Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats. Inflammopharmacology. 2018;: pubmed publisher
    To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats...
  52. Yoshida M, Westlin W, Wang N, Ingber D, Rosenzweig A, Resnick N, et al. Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton. J Cell Biol. 1996;133:445-55 pubmed
    ..vinculin, filamin, paxillin, as well as focal adhesion kinase (FAK), were copurified by this procedure, however talin was not...
  53. Yan B, Calderwood D, Yaspan B, Ginsberg M. Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. J Biol Chem. 2001;276:28164-70 pubmed
    b>Talin links integrin beta cytoplasmic domains to the actin cytoskeleton and is involved in the clustering and activation of these receptors...
  54. Jin J, Tien P, Cheng C, Song J, Huang C, Lin S, et al. Talin1 phosphorylation activates ?1 integrins: a novel mechanism to promote prostate cancer bone metastasis. Oncogene. 2015;34:1811-21 pubmed publisher
    ..Immunohistochemical staining demonstrated that talin S425 phosphorylation is significantly increased in human bone metastases when compared with normal tissues, ..
  55. Yang X, Yao W, Li Q, Liu H, Shi H, Gao Y, et al. Mechanism of Tang Luo Ning effect on attenuating of oxidative stress in sciatic nerve of STZ-induced diabetic rats. J Ethnopharmacol. 2015;174:1-10 pubmed publisher
    Tang Luo Ning recipe (TLN), a traditional Chinese herbal medicine based on Huangqi Guizhi Wuwu decoction, has been used clinically to treat diabetic peripheral neuropathy in China...
  56. Zhang B, Mo Z, Du W, Wang Y, Liu L, Wei Y. Intensity-modulated radiation therapy versus 2D-RT or 3D-CRT for the treatment of nasopharyngeal carcinoma: A systematic review and meta-analysis. Oral Oncol. 2015;51:1041-1046 pubmed publisher
    ..46; p=0.0004). In addition, the radiation-induced chronic toxicities rate of trismus and temporal lobe neuropathy (TLN) were also significantly lower in the IMRT group than in the control group (OR=0.18; 95% CI 0.04-0.83; p=0.03; OR=0...
  57. Li X, Zhou Q, Sunkara M, Kutys M, Wu Z, Rychahou P, et al. Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I ? by HECTD1 regulates focal adhesion dynamics and cell migration. J Cell Sci. 2013;126:2617-28 pubmed publisher
    Phosphatidylinositol 4-phosphate 5-kinase type I ? (PIPKI?90) binds talin and localizes at focal adhesions (FAs). Phosphatidylinositol (4,5)-bisphosphate (PIP2) generated by PIPKI?90 is essential for FA formation and cell migration...
  58. Chen Y, Zheng H, Liang G, Wang D, Qiu J, Fang Y. Comparison of Transperitoneal and Retroperitoneal Laparoscopic Nephrectomy for Nonfunctional Tuberculous Kidneys: A Single-Center Experience. J Laparoendosc Adv Surg Tech A. 2018;28:325-329 pubmed publisher
    ..and safety between retroperitoneal laparoscopic nephrectomy (RLN) and transperitoneal laparoscopic nephrectomy (TLN) for nonfunctional tuberculous kidneys (NTK)...
  59. Lin Y, Cheng Y, Huang J, Lin H, Yang B. Zap70 controls the interaction of talin with integrin to regulate the chemotactic directionality of T-cell migration. Mol Immunol. 2010;47:2022-9 pubmed publisher
    ..Instead of direct interacting with F-actin, Zap70 formed a complex with talin which is an integrin scaffold for F-actin...
  60. Wernimont S, Wiemer A, Bennin D, Monkley S, Ludwig T, Critchley D, et al. Contact-dependent T cell activation and T cell stopping require talin1. J Immunol. 2011;187:6256-67 pubmed publisher
    ..These results indicate that T cell proliferation requires sustained, talin1-mediated T cell-APC interactions and that talin1 is necessary for F-actin polarization and the stability of the IS. ..
  61. Garvalov B, Higgins T, Sutherland J, Zettl M, Scaplehorn N, Kocher T, et al. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol. 2003;161:33-9 pubmed
    ..However, using RNAi ablation, we demonstrate that zyxin is required to recruit Tes, as well as Mena and VASP, but not vinculin or paxillin, to focal adhesions. ..
  62. von Essen M, Rahikainen R, Oksala N, Raitoharju E, Seppälä I, Mennander A, et al. Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study. Atherosclerosis. 2016;255:43-53 pubmed publisher
    ..b>Talin and vinculin proteins are among the major constituents of FAs contributing to cellular well-being and ..
  63. Luo G, Herrera A, Horowits R. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. Biochemistry. 1999;38:6135-43 pubmed
    ..Finally, talin binds with high affinity to the LIM domain of N-RAP...
  64. Boyle T, Perales D, Rimsza J, Alam T, Boye D, Sears J, et al. Synthesis and characterization of thallium-salen derivatives for use as underground fluid flow tracers. Dalton Trans. 2018;47:4162-4174 pubmed publisher
    ..For 1, an additional TlN interaction was solved for each metal center; whereas, for 2, one of the two molecules in the matrix has a weak TlN ..
  65. Ringer P, Weißl A, Cost A, Freikamp A, Sabass B, Mehlich A, et al. Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1. Nat Methods. 2017;14:1090-1096 pubmed publisher
    ..Application of these techniques to new talin biosensors reveals an intramolecular tension gradient across talin-1 that is established upon integrin-mediated ..
  66. Genini M, Schwalbe P, Scholl F, Schafer B. Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma. Int J Cancer. 1996;66:571-7 pubmed
    ..osteoblast-specific factor-2 (OSF-2), 22-kDa smooth-muscle protein (SM22), clone A3351 (homologous to mouse talin), testican, thrombospondin-1 and thrombospondin-2 suggests involvement of these proteins in the genesis of the ..
  67. Cerecedo D, Cisneros B, Suárez Sánchez R, Hernández González E, Galván I. beta-Dystroglycan modulates the interplay between actin and microtubules in human-adhered platelets. Br J Haematol. 2008;141:517-28 pubmed publisher
    ..Altogether our data are indicative of a dynamic co-participation of actin filaments and microtubules in modulating focal contacts to achieve platelet function. ..
  68. Murakami M, Kameda K, Tsumoto H, Tsuda T, Masuda K, Utsunomiya R, et al. TLN-58, an Additional hCAP18 Processing Form, Found in the Lesion Vesicle of Palmoplantar Pustulosis in the Skin. J Invest Dermatol. 2017;137:322-331 pubmed publisher
    ..In-gel digestion analysis and protein sequencing confirmed the additional form as TLN-58...
  69. Wong J, Campbell D, Ngo N, Yeung F, Cheng G, Tang C, et al. Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes. BMC Med Genomics. 2016;9:75 pubmed
    ..The data is consistent with the rarity and sporadic presentation of CDD. ..
  70. Shoeman R, Hartig R, Hauses C, Traub P. Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease. Cell Biol Int. 2002;26:529-39 pubmed
    ..These included fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin...
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  72. Manso A, Okada H, Sakamoto F, Moreno E, Monkley S, Li R, et al. Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2017;114:E6250-E6259 pubmed publisher
    ..The ubiquitously expressed cytoskeletal protein talin (Tln) is a component of muscle costameres that links integrins ultimately to the sarcomere...
  73. Shattil S. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 2005;15:399-403 pubmed
    ..Here, the biochemical basis for and biological significance of this integrin-SFK interaction is summarized, and I propose a general mechanism for initiation of outside-in integrin signaling. ..
  74. Li Y, Tang R, Puan K, Law S, Tan S. The cytosolic protein talin induces an intermediate affinity integrin alphaLbeta2. J Biol Chem. 2007;282:24310-9 pubmed
    ..At least three alphaLbeta2 affinity states (low, intermediate, and high) were described. The cytosolic protein talin connects alphaLbeta2 to the actin filament...
  75. Fang K, Zhang J, Ren Y, Qian Y. Talin-1 correlates with reduced invasion and migration in human hepatocellular carcinoma cells. Asian Pac J Cancer Prev. 2014;15:2655-61 pubmed
    b>Talin-1 is a cytoskeleton protein that participates in cell migration and plays a role in tumor formation, migration, and metastasis in different types of cancer...
  76. Pagán A, Paterson K, Blythe H, Liversedge S. An inhibitory influence of transposed-letter neighbors on eye movements during reading. Psychon Bull Rev. 2016;23:278-84 pubmed publisher
    ..we extended these findings by investigating the effects of prior exposure to a word's transposed-letter neighbor (TLN) earlier in a sentence. TLNs are constituted from the same letters, but in different orders...
  77. Sateriale A, Miller P, Huston C. Knockdown of Five Genes Encoding Uncharacterized Proteins Inhibits Entamoeba histolytica Phagocytosis of Dead Host Cells. Infect Immun. 2016;84:1045-1053 pubmed publisher
    ..Two of the five encoded proteins, which we named E. histolytica ILWEQ (EhILWEQ) and E...
  78. Martel V, Vignoud L, Dupe S, Frachet P, Block M, Albiges Rizo C. Talin controls the exit of the integrin alpha 5 beta 1 from an early compartment of the secretory pathway. J Cell Sci. 2000;113 ( Pt 11):1951-61 pubmed
    b>Talin is a major cytosolic protein that links the intracellular domains of beta1 and beta3 integrins to the cytoskeleton. It is required for focal adhesion assembly...
  79. Ulmer T, Yaspan B, Ginsberg M, Campbell I. NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution. Biochemistry. 2001;40:7498-508 pubmed
    ..this reverse-turn tendency and markedly reduced the affinity of the head domain of the cytoskeletal protein, talin for the beta3 tail...
  80. Singh K, Al Greene N, Verriere T, Coburn L, Asim M, Barry D, et al. The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria. PLoS Pathog. 2016;12:e1005984 pubmed publisher
    ..rodentium to the colonic epithelium and decreased expression of Talin-1, a focal adhesion protein involved in the attachment of the bacterium...
  81. Lim J, Dupuy A, Critchley D, Caron E. Rap1 controls activation of the ?(M)?(2) integrin in a talin-dependent manner. J Cell Biochem. 2010;111:999-1009 pubmed publisher
    The small GTPase Rap1 and the cytoskeletal protein talin regulate binding of C3bi-opsonised red blood cells (RBC) to integrin ?(M)?(2) in phagocytic cells, although the mechanism has not been investigated...
  82. Bledzka K, Liu J, Xu Z, Perera H, Yadav S, Bialkowska K, et al. Spatial coordination of kindlin-2 with talin head domain in interaction with integrin ? cytoplasmic tails. J Biol Chem. 2012;287:24585-94 pubmed publisher
    Both talin head domain and kindlin-2 interact with integrin ? cytoplasmic tails, and they function in concert to induce integrin activation...
  83. Tang H, Yao L, Tao X, Yu Y, Chen M, Zhang R, et al. miR-9 functions as a tumor suppressor in ovarian serous carcinoma by targeting TLN1. Int J Mol Med. 2013;32:381-8 pubmed publisher
    ..In addition, we demonstrate that the focal adhesion protein, talin 1 (TLN1), whose expression has been associated with OSC development and progression to metastasis, is a direct ..
  84. Insua Y, Cámara J, Vázquez E, Fernández A, Rivera F, Silva M, et al. Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study. Int J Mol Sci. 2017;18: pubmed publisher
    ..53 vs. 11.70; OS: 10.37 vs. 24.13; months). In conclusion, our CTCs detection panel demonstrated efficacy for early treatment response assessment in mCRC patients, and with increased reliability compared to CT scan. ..
  85. Truttmann M, Misselwitz B, Huser S, Hardt W, Critchley D, Dehio C. Bartonella henselae engages inside-out and outside-in signaling by integrin ?1 and talin1 during invasome-mediated bacterial uptake. J Cell Sci. 2011;124:3591-602 pubmed publisher
    ..This is the first example of a bacterial entry process that fully exploits the bi-directional signaling capacity of integrin receptors in a talin1-specific manner. ..
  86. Webb R. Smooth muscle contraction and relaxation. Adv Physiol Educ. 2003;27:201-6 pubmed
    ..Removal of Ca(2+) from the cytosol and stimulation of myosin phosphatase initiate the process of smooth muscle relaxation...
  87. Wu Q, Zhang J, Koh W, Yu Q, Zhu X, Amsterdam A, et al. Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB J. 2015;29:4989-5005 pubmed publisher
    b>Talin (tln) binds and activates integrins to couple extracellular matrix-bound integrins to the cytoskeleton; however, its role in heart development is not well characterized...
  88. Luna E, Hitt A. Cytoskeleton--plasma membrane interactions. Science. 1992;258:955-64 pubmed
    ..General organizational themes are beginning to emerge from examination of this biochemical diversity. ..
  89. Salgia R, Sattler M, Pisick E, Li J, Griffin J. p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl. Exp Hematol. 1996;24:310-3 pubmed
    ..Here we show that certain focal adhesion proteins are also part of this complex, including paxillin and talin. The sites in paxillin required to bind to p120c-Cbl in this complex have been partially mapped...
  90. Izard T, Vonrhein C. Structural basis for amplifying vinculin activation by talin. J Biol Chem. 2004;279:27667-78 pubmed
    b>Talin interactions with vinculin are essential for focal adhesions. Curiously, talin contains three noncontiguous vinculin binding sites (VBS) that can bind individually to the vinculin head (Vh) domain...
  91. Mazaki Y, Hashimoto S, Sabe H. Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins. J Biol Chem. 1997;272:7437-44 pubmed
    ..to vinculin, and gamma bound to vinculin but only weakly to focal adhesion kinase, although both bound equally to talin. No additional proteins were found to bind to beta and gamma over those binding to alpha...
  92. Patil S, Jedsadayanmata A, Wencel Drake J, Wang W, Knezevic I, Lam S. Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic t. J Biol Chem. 1999;274:28575-83 pubmed
    ..motif in the beta(3) cytoplasmic tail and has been suggested to mediate the interaction of beta(3) integrins with talin. In the present study, we performed a double mutation (N744Q/P745A) in the integrin beta(3) subunit to test the ..