TAL1

Summary

Gene Symbol: TAL1
Description: TAL bHLH transcription factor 1, erythroid differentiation factor
Alias: SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia protein 1, T-cell acute lymphocytic leukemia 1, T-cell leukemia/lymphoma protein 5, class A basic helix-loop-helix protein 17, stem cell protein, tal-1 product
Species: human
Products:     TAL1

Top Publications

  1. Park S, Sun X. The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition. J Biol Chem. 1998;273:7030-7 pubmed
    The Tal1 oncogene is a class II basic helix-loop-helix (bHLH) transcription factor, overexpressed in as much as 60% of T cell acute lymphoblastic leukemia cases...
  2. Chang P, Draheim K, Kelliher M, Miyamoto S. NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells. Cancer Res. 2006;66:6008-13 pubmed
    ..Here, we show that the transcription factor TAL1 (also known as SCL) binds to the promoter of the NFKB1 gene that encodes p50 and represses its transcription to set ..
  3. Ravet E, Reynaud D, Titeux M, Izac B, Fichelson S, Romeo P, et al. Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis. Blood. 2004;103:3326-35 pubmed
    The transcription factor TAL1 has major functions during embryonic hematopoiesis and in adult erythropoiesis and megakaryocytopoiesis...
  4. Lazrak M, Deleuze V, Noel D, Haouzi D, Chalhoub E, Dohet C, et al. The bHLH TAL-1/SCL regulates endothelial cell migration and morphogenesis. J Cell Sci. 2004;117:1161-71 pubmed
    The basic helix-loop-helix tal-1 gene (or scl), known for its fundamental role in embryonic and adult hematopoiesis in vertebrates, is also required for embryonic vascular remodeling...
  5. Wen J, Huang S, Pack S, Yu X, Brandt S, Noguchi C. Tal1/SCL binding to pericentromeric DNA represses transcription. J Biol Chem. 2005;280:12956-66 pubmed
    b>Tal1/SCL is a basic helix-loop-helix transcription factor critical for normal hematopoiesis...
  6. Aplan P, Lombardi D, Reaman G, Sather H, Hammond G, Kirsch I. Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia. Blood. 1992;79:1327-33 pubmed
    The SCL gene, initially discovered at the site of a translocation breakpoint associated with the development of a stem cell leukemia, encodes a protein that contains the highly conserved basic helix-loop-helix (bHLH) motif found in a ..
  7. Aplan P, Nakahara K, Orkin S, Kirsch I. The SCL gene product: a positive regulator of erythroid differentiation. EMBO J. 1992;11:4073-81 pubmed
    The SCL (tal-1, TCL5) gene is a member of the basic domain, helix-loop-helix (bHLH) class of putative transcription factors...
  8. Hsu H, Wadman I, Baer R. Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Proc Natl Acad Sci U S A. 1994;91:3181-5 pubmed
    Tumor-specific activation of the TAL1 gene occurs in approximately 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL)...
  9. Huang S, Brandt S. mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor. Mol Cell Biol. 2000;20:2248-59 pubmed
    Activation of the TAL1 (or SCL) gene is the most frequent gain-of-function mutation in T-cell acute lymphoblastic leukemia (T-ALL)...

More Information

Publications105 found, 100 shown here

  1. Ryan D, Duncan J, Lee C, Kuchel P, Matthews J. Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12. Proteins. 2008;70:1461-74 pubmed
    The nuclear proteins TAL1 (T-cell acute leukaemia protein 1) and LMO2 (LIM-only protein 2) have critical roles in haematopoietic development, but are also often aberrantly activated in T-cell acute lymphoblastic leukaemia...
  2. Kusy S, Gerby B, Goardon N, Gault N, Ferri F, Gerard D, et al. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med. 2010;207:2141-56 pubmed publisher
    b>TAL1 (also known as SCL) is expressed in >40% of human T cell acute lymphoblastic leukemias (T-ALLs)...
  3. Sanda T, LAWTON L, Barrasa M, Fan Z, Kohlhammer H, Gutierrez A, et al. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 2012;22:209-21 pubmed publisher
    The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the molecular pathogenesis of T-ALL...
  4. Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, et al. Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias. Genes Chromosomes Cancer. 1990;1:194-208 pubmed
    ..The translocation breakpoints involved the TCR delta gene on chromosome 14 and the SCL locus on chromosome band Ip32 that was recently shown to be activated by the t(1;14) translocation of the DU 528 ..
  5. Aplan P, Begley C, Bertness V, Nussmeier M, Ezquerra A, Coligan J, et al. The SCL gene is formed from a transcriptionally complex locus. Mol Cell Biol. 1990;10:6426-35 pubmed
    We describe the structural organization of the human SCL gene, a helix-loop-helix family member which we believe plays a fundamental role in hematopoietic differentiation. The SCL locus is composed of eight exons distributed over 16 kb...
  6. Ono Y, Fukuhara N, Yoshie O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol. 1998;18:6939-50 pubmed
    Previously, we have shown that TAL1 and the LIM-only protein gene (LMO) are regularly coactivated in T-cell acute lymphoblastic leukemia (T-ALL)...
  7. Huang S, Qiu Y, Stein R, Brandt S. p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein. Oncogene. 1999;18:4958-67 pubmed
    Activation of the TAL1 (or SCL) gene, originally identified through its involvement by a recurrent chromosomal translocation, is the most frequent gain-of-function mutation recognized in T-cell acute lymphoblastic leukemia (T-ALL)...
  8. Calkhoven C, Muller C, Martin R, Krosl G, Pietsch H, Hoang T, et al. Translational control of SCL-isoform expression in hematopoietic lineage choice. Genes Dev. 2003;17:959-64 pubmed
    We investigated the translational regulation of SCL protein expression and its role in hematopoietic lineage choice...
  9. Delabesse E, Ogilvy S, Chapman M, Piltz S, Gottgens B, Green A. Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo. Mol Cell Biol. 2005;25:5215-25 pubmed
    The stem cell leukemia (SCL) gene, also known as TAL-1, encodes a basic helix-loop-helix protein that is essential for the formation of all hematopoietic lineages, including primitive erythropoiesis...
  10. Brunet de la Grange P, Armstrong F, Duval V, Rouyez M, Goardon N, Romeo P, et al. Low SCL/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells. Blood. 2006;108:2998-3004 pubmed
    Stem cell leukemia/T cell acute leukemia 1 (SCL/TAL1) plays a key role in the development of murine primitive hematopoiesis but its functions in adult definitive hematopoiesis are still unclear...
  11. Hu X, Li X, Valverde K, Fu X, NOGUCHI C, Qiu Y, et al. LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc Natl Acad Sci U S A. 2009;106:10141-6 pubmed publisher
    b>TAL1 is a critical transcription factor required for hematopoiesis. However, perturbation of its activity often leads to T cell leukemia...
  12. Palii C, Perez Iratxeta C, Yao Z, Cao Y, Dai F, Davison J, et al. Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages. EMBO J. 2011;30:494-509 pubmed publisher
    b>TAL1/SCL is a master regulator of haematopoiesis whose expression promotes opposite outcomes depending on the cell type: differentiation in the erythroid lineage or oncogenesis in the T-cell lineage...
  13. Finger L, Kagan J, Christopher G, Kurtzberg J, Hershfield M, Nowell P, et al. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A. 1989;86:5039-43 pubmed
    ..of chromosome 1 at band p32, adjacent to the chromosomal breakpoint, encodes a transcriptional unit designated TCL5 (T-cell leukemia/lymphoma 5)...
  14. Lecuyer E, Herblot S, Saint Denis M, Martin R, Begley C, Porcher C, et al. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood. 2002;100:2430-40 pubmed
    ..Stem cell leukemia (SCL, also known as TAL1 [T-cell acute lymphoblastic leukemia 1]) is a tissue-specific basic helix-loop-helix (bHLH) factor that plays a ..
  15. Reynaud D, Ravet E, Titeux M, Mazurier F, Renia L, Dubart Kupperschmitt A, et al. SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment. Blood. 2005;106:2318-28 pubmed
    ..Stem cell leukemia/T-cell acute lymphoblastic leukemia 1 (SCL/TAL1), a basic helix-loop-helix (bHLH) transcription factor, plays key roles in controlling the development of primitive ..
  16. Palomero T, Odom D, O Neil J, Ferrando A, Margolin A, Neuberg D, et al. Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood. 2006;108:986-92 pubmed
    ..b>TAL1/SCL is a basic helix-loop-helix (bHLH) transcription factor oncogene aberrantly expressed in 60% of human T-ALLs...
  17. Lecuyer E, Larivière S, Sincennes M, Haman A, Lahlil R, Todorova M, et al. Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction. J Biol Chem. 2007;282:33649-58 pubmed
    ..The basic helix-loop-helix factor SCL and the LIM-only protein LMO2 are components of transcription factor complexes that are essential for hematopoiesis...
  18. Dixit S, Kalkur C, Sattur A, Bornstein M, Melton F. Scleroderma and dentistry: Two case reports. J Med Case Rep. 2016;10:297 pubmed
    ..Her serological reports were positive for antinuclear antibodies against centromere B, Scl-70, and Ro-52. A hand and wrist radiograph revealed acro-osteolysis of the middle finger on her right hand...
  19. Adewuya O, Adebayo R, Ajibade A, Odunlami G, Akintomide A, Ogunyemi S, et al. Mixed connective tissue disease complicated by heart failure in Ile-Ife, Nigeria: management challenges in a resource-limited economy. Int Med Case Rep J. 2018;11:307-312 pubmed publisher
    ..normal, elevated rheumatoid factor, speckled antinuclear antibody pattern, negative anticentromere antibody, anti Scl-70 and anticyclic citrullinated peptide. Chest X-ray/CT revealed pulmonary fibrosis...
  20. Shen L, Zhu J, Chen F, Lin W, Cai J, Zhong J, et al. RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study. BMC Cancer. 2015;15:970 pubmed publisher
    ..Consequently, primitive hematopoiesis was enhanced by upregulation of gata2 and scl, while erythropoiesis was downregulated due to the suppression of gata1...
  21. Bremer H, Lattwein E, Renneker S, Lilliehöök I, Rönnelid J, Hansson Hamlin H. Identification of specific antinuclear antibodies in dogs using a line immunoassay and enzyme-linked immunosorbent assay. Vet Immunol Immunopathol. 2015;168:233-41 pubmed publisher
    ..including the Ro-60 and Ro-52 subcomponents), SS-B, histidyl tRNA synthetase (Jo-1), topoisomerase I antigen (Scl-70), polymyositis-scleroderma antigen (PM-Scl) and proliferating cell nuclear antigen (PCNA) was also noted in ..
  22. Rudzki L, Ostrowska L, Pawlak D, Małus A, Pawlak K, Waszkiewicz N, et al. Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study. Psychoneuroendocrinology. 2019;100:213-222 pubmed publisher
    ..severity of psychiatric symptoms was assessed using Hamilton Depression Rating Scale (HAM-D 17), Symptom Checklist (SCL-90) and Perceived Stress Scale (PSS-10)...
  23. Kobayashi Y, Sahara T, Ohgiya S, Kamagata Y, Fujimori K. Systematic optimization of gene expression of pentose phosphate pathway enhances ethanol production from a glucose/xylose mixed medium in a recombinant Saccharomyces cerevisiae. AMB Express. 2018;8:139 pubmed publisher
    ..Although the activities and thermostabilities of the four PPP enzymes (transaldolase: TAL1, transketolase: TKL1, ribose-5-phosphate ketol-isomerase: RKI1 and D-ribulose-5-phosphate 3-epimerase: RPE1) can ..
  24. Morin F, Kavian N, Marut W, Chéreau C, Cerles O, Grange P, et al. Inhibition of EGFR Tyrosine Kinase by Erlotinib Prevents Sclerodermatous Graft-Versus-Host Disease in a Mouse Model. J Invest Dermatol. 2015;135:2385-2393 pubmed publisher
    ..Therefore, we tested whether Erlotinib, an EGFR tyrosine kinase inhibitor, can prevent sclerodermatous GVHD (Scl-GVHD). Scl-GVHD was induced in BALB/c mice by B10.D2 bone marrow and spleen cell transplantation...
  25. Buhmann C. Traumatized refugees: morbidity, treatment and predictors of outcome. Dan Med J. 2014;61:B4871 pubmed
    ..of PTSD, depression, anxiety, pain and somatization, quality of life and level of functioning (HTQ, HSCL-25, SCL-90, WHO-5, SDS, VAS, Hamilton, GAF)...
  26. Linde J, Simon G, Ludman E, Ichikawa L, Operskalski B, Arterburn D, et al. A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression. Ann Behav Med. 2011;41:119-30 pubmed publisher
    ..Mean Patient Health Questionnaire and Hopkins Symptom Checklist (SCL-20) scores indicated moderate to severe baseline depression...
  27. Holper L, Aleksandrowicz A, Müller M, Ajdacic Gross V, Haker H, Fallgatter A, et al. Brain correlates of verbal fluency in subthreshold psychosis assessed by functional near-infrared spectroscopy. Schizophr Res. 2015;168:23-9 pubmed publisher
    ..Based on the SCL-90-R subscales 'Paranoid Ideation' and 'Psychoticism' a total sample of 188 subjects was assigned to four groups ..
  28. Valge Archer V, Osada H, Warren A, Forster A, Li J, Baer R, et al. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc Natl Acad Sci U S A. 1994;91:8617-21 pubmed
    ..factors such as the LIM proteins RBTN1 and RBTN2 and the DNA-binding basic helix-loop-helix transcription factor TAL1 associated with T-cell acute lymphocytic leukemia...
  29. Langlands K, Yin X, Anand G, Prochownik E. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J Biol Chem. 1997;272:19785-93 pubmed
    ..the myogenic regulatory factors (MRFs: MyoD, myogenin, Myf-5 and MRF4/Myf-6), and the hematopoietic factors (Scl/Tal-1, Tal-2, and Lyl-1) were tested in a quantitative yeast 2-hybrid assay...
  30. Arrindell W, Urbán R, Carrozzino D, Bech P, Demetrovics Z, Roozen H. SCL-90-R emotional distress ratings in substance use and impulse control disorders: One-factor, oblique first-order, higher-order, and bi-factor models compared. Psychiatry Res. 2017;255:173-185 pubmed publisher
  31. Gelegen V, Tamam L. Prevalence and clinical correlates of intermittent explosive disorder in Turkish psychiatric outpatients. Compr Psychiatry. 2018;83:64-70 pubmed publisher
    ..SCID I) and the Structured Clinical Interview for DSM-IV personality disorders (SCID II), Symptom Checklist-90 (SCL-90), Wender Utah Rating Scale, Adult Attention Deficit Hyperactivity Disorder (ADHD) DSM-IV Based Diagnostic ..
  32. Tsuzuki S, Hong D, Gupta R, Matsuo K, Seto M, Enver T. Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med. 2007;4:e172 pubmed
  33. Saffari M, Pakpour A, Yaghobidoot M, Al Zaben F, Koenige H. Cross-cultural adaptation of the spinal cord lesion-related coping strategies questionnaire for use in Iran. Injury. 2015;46:1539-44 pubmed publisher
    ..validity and reliability of the Iranian version of the spinal cord lesion-related coping strategies questionnaire (SCL CSQ-I) in persons with spinal cord injury (SCI)...
  34. Westerhof G, Beernink J, Sools A. Who Am I? A Life Story Intervention for Persons With Intellectual Disability and Psychiatric Problems. Intellect Dev Disabil. 2016;54:173-86 pubmed publisher
    ..The current study provides a first evaluation of the intervention. A symptom checklist (SCL-90) was used in a pre- and post-follow-up design, and a qualitative evaluation of the intervention was carried out ..
  35. Bian S, Jin J, Dong J, Li Q, Yu J, Tang C, et al. A higher baseline somatization score at sea level as an independent predictor of acute mountain sickness. Physiol Behav. 2016;167:202-208 pubmed publisher
    ..aimed to identify the predictive values of psychological factors that are evaluated by the Symptoms Checklist-90 (SCL-90) for acute mountain sickness (AMS)...
  36. Durmaz O, Kemer S, Mutluer T, Bütün E. Psychiatric dimensions in mothers of children with primary nocturnal enuresis: A controlled study. J Pediatr Urol. 2017;13:62.e1-62.e6 pubmed publisher
    ..including the Eysenck Personality Questionnaire Revised Abbreviated (EPQR-A), the Symptom Checklist-90 (SCL-90-R), and the Childhood Trauma Questionnaire (CTQ), in addition to a sociodemographic form including 9 structured "..
  37. Cruz Domínguez M, García Collinot G, Saavedra M, Medina G, Carranza Muleiro R, Vera Lastra O, et al. Clinical, biochemical, and radiological characterization of the calcinosis in a cohort of Mexican patients with systemic sclerosis. Clin Rheumatol. 2017;36:111-117 pubmed publisher
    ..Patients with calcinosis had a higher score of Rodnan scale, Mesdger DSS, and frequency of anti-nucleolar and anti-Scl-70 antibodies compared to those without calcinosis...
  38. Lappalainen P, Langrial S, Oinas Kukkonen H, Tolvanen A, Lappalainen R. Web-based acceptance and commitment therapy for depressive symptoms with minimal support: a randomized controlled trial. Behav Modif. 2015;39:805-34 pubmed publisher
    ..were evaluated with standardized self-reporting measures (Beck Depression Inventory [BDI-II], Symptom Checklist-90 [SCL-90], Acceptance and Action Questionnaire [AAQ-2], Five Facet Mindfulness Questionnaire [FFMQ], Automatic Thoughts ..
  39. Midrio P, Mosiello G, Ausili E, Gamba P, Marte A, Lombardi L, et al. Peristeen(®) transanal irrigation in paediatric patients with anorectal malformations and spinal cord lesions: a multicentre Italian study. Colorectal Dis. 2016;18:86-93 pubmed publisher
    ..9% to 9.8% and in SCLs from 31.7% to 10%. At T0, the Bristol Stool Scale types were 1-2 in 45% of ARMs and 77.5% of SCL patients, whereas at T1 types 1-2 were recorded in only 2.5% of SCL patients. QoL improved in both groups...
  40. Li W, Xu Q, He Y, Liu Y, Yang S, Wang Z, et al. Anti-Tumor Effect of Steamed Codonopsis lanceolata in H22 Tumor-Bearing Mice and Its Possible Mechanism. Nutrients. 2015;7:8294-307 pubmed publisher
    ..lanceolata (SCL) and what mechanisms are involved remain largely unknown...
  41. Sorbara L, Zimmerman A, Mitchell G, Richdale K, Lam D, Kinoshita B, et al. Multicenter Testing of a Risk Assessment Survey for Soft Contact Lens Wearers With Adverse Events: A Contact Lens Assessment in Youth Study. Eye Contact Lens. 2018;44:21-28 pubmed publisher
    ..among participants with serious and significant (S&S) contact lens-related corneal inflammatory events, those with other events (non-S&S), and healthy controls matched for age, gender, and soft contact lens (SCL) wear frequency.
  42. Zhang K, Liu J, Guo Y, Li Y, Ma X, Lei Z. Synthesis of temperature, pH, light and dual-redox quintuple-stimuli-responsive shell-crosslinked polymeric nanoparticles for controlled release. Mater Sci Eng C Mater Biol Appl. 2018;87:1-9 pubmed publisher
    Herein, we prepared a novel quintuple-stimuli-responsive shell-crosslinked (SCL) nanocontainer in respond to temperature, pH, light, and oxidation or reduction species...
  43. Zhang J, Li L, Baldwin A, Friedman A, Paz Priel I. Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells. PLoS ONE. 2015;10:e0130441 pubmed publisher
    ..1 and diminished Gata1, Klf1, and SCL/Tal1 in IKKβ deficient Lineage-Sca1+c-Kit+ (LSK) cells...
  44. Peabody M, Laird M, Vlasschaert C, Lo R, Brinkman F. PSORTdb: expanding the bacteria and archaea protein subcellular localization database to better reflect diversity in cell envelope structures. Nucleic Acids Res. 2016;44:D663-8 pubmed publisher
    Protein subcellular localization (SCL) is important for understanding protein function, genome annotation, and has practical applications such as identification of potential vaccine components or diagnostic/drug targets...
  45. Andreeva E, Brenner M, Theorell T, Goldberg M. Risk of psychological ill health and methods of organisational downsizing: a cross-sectional survey in four European countries. BMC Public Health. 2017;17:758 pubmed publisher
    ..in telephone interviews with brief subscales from Hospital Anxiety Scale (HADS-A), Hopkins Symptom Checklist (SCL-CD6) and Maslach Burnout Inventory (MBI-GS). Data were analyzed using logistic regression...
  46. Cristofoli F, De Keersmaecker B, De Catte L, Vermeesch J, Van Esch H. Novel STIL Compound Heterozygous Mutations Cause Severe Fetal Microcephaly and Centriolar Lengthening. Mol Syndromol. 2017;8:282-293 pubmed publisher
    STIL (SCL/TAL1 interrupting locus) is a core component of the centriole duplication process. STIL mutations have been associated with both autosomal recessive primary microcephaly (MCPH) and holoprosencephaly...
  47. Reischauer S, Stone O, Villasenor A, Chi N, Jin S, Martin M, et al. Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 2016;535:294-8 pubmed publisher
    ..Epistasis experiments reveal that it functions upstream of etv2 and tal1, the earliest expressed endothelial and haematopoietic transcription factor genes identified to date...
  48. Farsam V, Basu A, Gatzka M, Treiber N, Schneider L, Mulaw M, et al. Senescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration. Oncotarget. 2016;7:83554-83569 pubmed publisher
    ..Silencing Chemerin in senescent fibroblasts or the CCRL2 and GPR1 receptors in the SCL-1 cSCC cell line abrogates the Chemerin-mediated chemotaxis...
  49. Orellana Rios C, Radbruch L, Kern M, Regel Y, Anton A, Sinclair S, et al. Mindfulness and compassion-oriented practices at work reduce distress and enhance self-care of palliative care teams: a mixed-method evaluation of an "on the job" program. BMC Palliat Care. 2017;17:3 pubmed publisher
    ..were the Perceived Stress Questionnaire, the Maslach Burnout Inventory, the somatic complaints subscale of the SCL-90-R, the Emotion Regulation Skills Questionnaire, the Hospital Anxiety and Depression Scale, and a Goal Attainment ..
  50. Hase M, Balmaceda U, Hase A, Lehnung M, Tumani V, Huchzermeier C, et al. Eye movement desensitization and reprocessing (EMDR) therapy in the treatment of depression: a matched pairs study in an inpatient setting. Brain Behav. 2015;5:e00342 pubmed publisher
    ..The EMDR group showed a greater reduction in depressive symptoms as measured by the SCL-90-R depression subscale. This difference was significant even when adjusted for duration of treatment...
  51. Martel C, Vignaud G, Liozon E, Magy L, Gallouedec G, Ly K, et al. Contribution of dot-blot assay to the diagnosis and management of myositis: a three-year practice at a university hospital centre. Clin Exp Rheumatol. 2016;34:918-924 pubmed
    ..the prescriptions of an IIM specific dot-blot assay (8 autoantigens including Jo-1, PL-7, PL-12, SRP, Mi-2, Ku, PM/Scl and Scl-70) over a 38-month period...
  52. Zhang S, Li Z, Liu Z, Miao G, Liu B. MicroRNA15b regulates apoptosis of cutaneous squamous cell carcinoma SCL-1 cell line: a mechanism study. Eur Rev Med Pharmacol Sci. 2017;21:227-233 pubmed
    ..study was focused on the effect of microRNA15b on cell viability and apoptosis of cutaneous squamous cell carcinoma SCL-1 cell line. MicroRNA15b and control microRNA were synthesized and transfected into SCL-1 cells, respectively...
  53. Morse A, Schindeler A, McDonald M, Kneissel M, Kramer I, Little D. Sclerostin antibody augments the anabolic bone formation response in a mouse model of mechanical tibial loading. J Bone Miner Res. 2017;: pubmed publisher
    ..Antibodies targeting and neutralizing sclerostin (Scl-Ab) have been shown to increase bone mass and reduce fracture risk...
  54. Ciocca G, Solano C, Di Lorenzo G, Limoncin E, Mollaioli D, Carosa E, et al. Bisexuality among a cohort of university students: prevalence and psychological distress. Int J Impot Res. 2018;30:79-84 pubmed publisher
    ..The cross-sectional analysis for psychological symptoms, with the Symptoms Check List-90 Revised (SCL-90-R), revealed that bisexual subjects have statistically significant higher scores on some symptomatic scales ..
  55. McGregor B, Syrjala K, Dolan E, Langer S, Redman M. The effect of pre-transplant distress on immune reconstitution among adult autologous hematopoietic cell transplantation patients. Brain Behav Immun. 2013;30 Suppl:S142-8 pubmed publisher
    ..2-14 days before admission using the Cancer and Treatment Distress (CTXD) scale, and the Symptom Checklist-90-R (SCL-90-R) anxiety and depression subscales...
  56. Niderla Bielińska J, Gula G, Flaht Zabost A, Jankowska Steifer E, Czarnowska E, Radomska Leśniewska D, et al. 3-D reconstruction and multiple marker analysis of mouse proepicardial endothelial cell population. Microvasc Res. 2015;102:54-69 pubmed publisher
    ..proepicardial ECs express both early and late EC-specific markers such as CD31, Flk-1, Lyve-1 and Tie-2 but not SCL/Tal1, vWF, Dll4 or Notch1...
  57. Jiang X, Luo X, Zhou N. Two Polyhydroxyalkanoate Synthases from Distinct Classes from the Aromatic Degrader Cupriavidus pinatubonensis JMP134 Exhibit the Same Substrate Preference. PLoS ONE. 2015;10:e0142332 pubmed publisher
    ..and PhaC2 were shown to exhibit typical class I PHA synthase substrate specificity to make short-chain-length (SCL) PHA from 3-hydroxybutyryl-CoA and failed to make medium-chain-length (MCL) PHA from 3-hydroxyoctanoyl-CoA...
  58. Schür R, Boks M, Geuze E, Prinsen H, Verhoeven Duif N, Joels M, et al. Development of psychopathology in deployed armed forces in relation to plasma GABA levels. Psychoneuroendocrinology. 2016;73:263-270 pubmed publisher
    ..Mental health problems and depressive symptoms were measured with the Dutch revised Symptom Checklist (SCL-90) and PTSD symptoms with the Dutch Self-Rating Inventory for PTSD (SRIP)...
  59. Sundquist J, Palmer K, Johansson L, Sundquist K. The effect of mindfulness group therapy on a broad range of psychiatric symptoms: A randomised controlled trial in primary health care. Eur Psychiatry. 2017;43:19-27 pubmed publisher
    ..of psychiatric symptoms were evaluated at baseline and at the 8-week follow-up using the Symptom Checklist-90 (SCL-90). Mindful attention awareness was also evaluated using the Mindful Attention Awareness Scale (MAAS)...
  60. Begley C, Aplan P, Denning S, Haynes B, Waldmann T, Kirsch I. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proc Natl Acad Sci U S A. 1989;86:10128-32 pubmed
    We have identified the human gene, SCL. We discovered this gene because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid and lymphoid differentiation ..
  61. Chen Q, Yang C, Tsan J, Xia Y, Ragab A, Peiper S, et al. Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. J Exp Med. 1990;172:1403-8 pubmed
    ..Hence, the translocated allele of tal-1 is truncated in a manner that reduces its amino acid coding potential. ..
  62. Wadman I, Li J, Bash R, Forster A, Osada H, Rabbitts T, et al. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J. 1994;13:4831-9 pubmed
    ..RBTN1 and RBTN2 encode highly related proteins that possess cysteine-rich LIM motifs. TAL1, TAL2 and LYL1 encode a unique subgroup of basic helix-loop-helix (bHLH) proteins that share exceptional homology ..
  63. Goardon N, Schuh A, Hajar I, Ma X, Jouault H, Dzierzak E, et al. Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation. Blood. 2002;100:491-500 pubmed
    ..Altogether, these results enlighten the fine-tuning of TAL-1 expression during adult hematopoiesis and indicate why TAL-1 expression has to be switched off in the lymphoid lineages. ..
  64. Nie L, Wu H, Sun X. Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP. J Biol Chem. 2008;283:684-92 pubmed
    ..Here, we show that Notch signaling also accelerated the degradation of Tal1/SCL (T cell acute leukemia 1/stem cell leukemia) protein, a basic helix-loop-helix protein involved in the ..
  65. Sudhakar N, Nirmala K, Rajalekshmy K, Rajkumar T. Does TAL-1 deletion contribute to the high incidence of T-cell acute lymphoblastic leukemia in South Indian patients?. Asian Pac J Cancer Prev. 2008;9:127-30 pubmed
    ..Hence the present study indicates that TAL-1 deletion alone does not contribute to the high incidence of T-ALL in South Indian patients. ..
  66. Diffner E, Beck D, Gudgin E, Thoms J, Knezevic K, Pridans C, et al. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. Blood. 2013;121:2289-300 pubmed publisher
  67. Zhou Y, Kurukuti S, Saffrey P, Vukovic M, Michie A, Strogantsev R, et al. Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL. Blood. 2013;122:4199-209 pubmed publisher
    b>TAL1 is an important regulator of hematopoiesis and its expression is tightly controlled despite complexities in its genomic organization...
  68. Kochanska G, Brock R, Boldt L. A cascade from disregard for rules of conduct at preschool age to parental power assertion at early school age to antisocial behavior in early preadolescence: Interplay with the child's skin conductance level. Dev Psychopathol. 2017;29:875-885 pubmed publisher
    ..This process may be particularly likely for children with low skin conductance level (SCL)...
  69. Kara E, Manna D, Løset G, Schneider E, Craik C, Kanse S. Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thromb Haemost. 2017;117:1750-1760 pubmed publisher
    ..Applying phage display and positional scanning substrate combinatorial library (PS-SCL) approaches we have characterised the specificity of FSAP towards small peptides...
  70. Kogawa M, Khalid K, Wijenayaka A, Ormsby R, Evdokiou A, Anderson P, et al. Recombinant sclerostin antagonizes effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size. Am J Physiol Cell Physiol. 2018;314:C53-C61 pubmed publisher
    ..Moreover, it appears that sclerostin, acting on osteocytes, can negate this effect by modulating the dimensions of the lacunocanalicular porosity and the composition of the periosteocyte matrix. ..
  71. Vitelli L, Condorelli G, Lulli V, Hoang T, Luchetti L, Croce C, et al. A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts. Mol Cell Biol. 2000;20:5330-42 pubmed
    ..These data indicate that this pentameric complex assembled in maturing erythroblasts plays an important regulatory role in c-kit downmodulation; hypothetically, the complex may regulate the expression of other critical erythroid genes. ..
  72. Baron M. Induction of embryonic hematopoietic and endothelial stem/progenitor cells by hedgehog-mediated signals. Differentiation. 2001;68:175-85 pubmed
    ..Despite the identification of genes such as Flk1, SCL/tal-1, Cbfa2/Runx1/AML1 and CD34 that are expressed during the induction of primitive hematopoiesis and ..
  73. McCormack M, Hall M, Schoenwaelder S, Zhao Q, Ellis S, Prentice J, et al. A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood. 2006;108:2248-56 pubmed
    ..Here we show in mice that the transcription factor Scl is critical for platelet production after chemotherapy and in thrombopoiesis induced by administration of TPO...
  74. Terme J, Lhermitte L, Asnafi V, Jalinot P. TGF-beta induces degradation of TAL1/SCL by the ubiquitin-proteasome pathway through AKT-mediated phosphorylation. Blood. 2009;113:6695-8 pubmed publisher
    T-cell acute lymphoblastic leukemia 1 (TAL1), also known as stem cell leukemia (SCL), plays important roles in differentiation of hematopoietic and endothelial cells and is deregulated in a high percentage of T-cell acute lymphoblastic ..
  75. Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, et al. T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. J Biol Chem. 2012;287:36720-31 pubmed publisher
    ..DNA binding of the basic helix-loop-helix transcription factor, TAL1/SCL, is required for normal erythropoiesis...
  76. Fleskens V, Mokry M, van der Leun A, Huppelschoten S, Pals C, Peeters J, et al. FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2. Oncogene. 2016;35:4141-8 pubmed publisher
    T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex...
  77. Shindi R, Almehairi A, Negm O, Kalsheker N, Gale N, Shale D, et al. Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease. Clin Immunol. 2017;183:344-353 pubmed publisher
    ..the autoantigenic specificities of IgM AAbs compared to IgG AAbs in the COPD sera: for example, AAbs to histone and scl-70 were mainly IgG, whereas AAbs to CENP-B and La/ssB were mainly IgM; by contrast, IgM and IgG AAbs to collagen-V ..
  78. Lafosse E, Romín D, Esteve Taboada J, Wolffsohn J, Talens Estarelles C, García Lázaro S. Comparison of the influence of corneo-scleral and scleral lenses on ocular surface and tear film metrics in a presbyopic population. Cont Lens Anterior Eye. 2018;41:122-127 pubmed publisher
    To assess and compare the effect of the corneo-scleral lenses (C-ScL) and scleral lenses (ScL) on tear film parameters and central corneal thickness (CCT) in healthy presbyopic subjects...
  79. Yoo H, Jin S, Lee Y, Song C, Ji Y, Tae K. The role of psychological factors in the development of burning mouth syndrome. Int J Oral Maxillofac Surg. 2018;47:374-378 pubmed publisher
    ..The Symptom Checklist-90-Revised (SCL-90-R) questionnaire was used to evaluate the role of psychological factors in the development of BMS...
  80. Shen Y, Zhu X, Sun K. [Analysis of occupational health examination data of operation and maintenance personnel in wind farm]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2017;35:627-629 pubmed publisher
    ..2013?3?7????????????????????????17?????????????151???????????????????????336??????????????????????????????????scl-90???????????????nmq??????????????????? ??? ????????????????88.7%?scl-90????????????p<0...
  81. Cheng J, Hsu H, Hwang L, Baer R. Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. Oncogene. 1993;8:677-83 pubmed
    b>TAL1 gene rearrangement is observed in nearly 30% of patients with T-cell acute lymphoblastic leukemia (T-ALL), and thus it represents the most common genetic lesion associated with this disease...
  82. Correia N, Melão A, Póvoa V, Sarmento L, Gómez de Cedrón M, Malumbres M, et al. microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. Oncotarget. 2016;7:8268-81 pubmed publisher
    The transcription factor TAL1 is a proto-oncogene whose aberrant expression in committed T-cell precursors is associated with the development of T-cell acute lymphoblastic leukemia (T-ALL)...
  83. Gomez P, von Gunten A, Danuser B. Autonomic nervous system reactivity within the valence-arousal affective space: Modulation by sex and age. Int J Psychophysiol. 2016;109:51-62 pubmed publisher
    ..heart rate (HR) decelerated with increasing self-reported unpleasantness, whereas skin conductance level (SCL) and pupil size (PS) increased with increasing self-rated arousal...
  84. Wang F, Song W, Zhao H, Ma Y, Li Y, Zhai D, et al. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Res. 2017;27:416-439 pubmed publisher
    ..Mechanistically, miR-124 targets TAL1 and c-MYB, two transcription factors involved in normal erythropoiesis...
  85. Frazer L, Santschi E, Fischer K. The impact of subchondral bone cysts on local bone stresses in the medial femoral condyle of the equine stifle joint. Med Eng Phys. 2017;48:158-167 pubmed publisher
    Subchondral lucency (SCL), also referred to as subchondral bone cysts, can cause clinical problems in horses and humans...
  86. Sun C, Chen M, Ruan Z, Han R, Wang W, Wang F, et al. [Study on Myelopoietic Functions of miR-191 by Using Zebrafish Model]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1172-1177 pubmed publisher
    ..The antisense RNA probes with high sensitivity and specificity of erythroid genes (gata 1, scl, hbbe 3, lmo 2) and myelomonocytic genes (pu...
  87. Karamanolis G, Denaxas K, Panopoulos S, Bournia K, Zorbala A, Kamberoglou D, et al. Severe oesophageal disease and its associations with systemic sclerosis. Clin Exp Rheumatol. 2017;35 Suppl 106:82-85 pubmed
    ..characteristics, patient-reported symptoms, SSc subtypes, pulmonary fibrosis, cutaneous ulcers, and anti-Scl-70 positivity were compared between SSc patients with or without scleroderma oesophagus...
  88. Dedeoğlu R, Adrovic A, Oztunc F, Sahin S, Barut K, Kasapcopur O. New Insights into Cardiac Involvement in Juvenile Scleroderma: A Three-Dimensional Echocardiographic Assessment Unveils Subclinical Ventricle Dysfunction. Pediatr Cardiol. 2017;38:1686-1695 pubmed publisher
    ..were lower in the JSSc patients with interstitial lung fibrosis, arthritis, muscle weakness, weight loss, and anti-scl 70 antibodies than in the JSSc patients without these variables. We found that a GCS of <34...
  89. Stanulovic V, Cauchy P, Assi S, Hoogenkamp M. LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage. Nucleic Acids Res. 2017;45:9874-9888 pubmed publisher
    ..Genome-wide approaches indicated that LMO2 is required at the haemangioblast stage to position the TAL1/LMO2/LDB1 complex to regulatory elements that are important for the establishment of the haematopoietic ..
  90. Reiter S, Eli I, Friedman Rubin P, Emodi Perlman A, Ziv Baran T, Winocur E. Comparing Axis II Scores According to the RDC/TMD and DC/TMD in Israeli Patients. J Oral Facial Pain Headache. 2017;31:323–330 pubmed publisher
    To use the Symptom Checklist-90-Revised (SCL-90-R)-based instruments of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and the Primary Care Evaluation of Mental Disorders (PRIME-MD)-based instruments of the ..
  91. Siegel P, Warren R, Jacobson G, Merritt E. Masking exposure to phobic stimuli reduces fear without inducing electrodermal activity. Psychophysiology. 2017;: pubmed publisher
    ..b>SCL increases during VBE were strongly negatively correlated with the reduction of self-reported fear of the tarantula: ..
  92. Cross M, Heyworth C, Murrell A, Bockamp E, Dexter T, Green A. Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line. Oncogene. 1994;9:3013-6 pubmed
    ..Here, we report that the genes for the lineage-restricted transcription factors SCL, GATA-1 and GATA-2 are expressed in all multipotent, IL-3-dependent, haemopoietic progenitor cell lines tested...