TAGLN

Summary

Gene Symbol: TAGLN
Description: transgelin
Alias: SM22, SM22-alpha, SMCC, TAGLN1, WS3-10, transgelin, 22 kDa actin-binding protein, smooth muscle protein 22-alpha, transgelin variant 2
Species: human
Products:     TAGLN

Top Publications

  1. Li N, Zhang J, Liang Y, Shao J, Peng F, Sun M, et al. A controversial tumor marker: is SM22 a proper biomarker for gastric cancer cells?. J Proteome Res. 2007;6:3304-12 pubmed
    b>SM22, a dominant protein in smooth muscle cells (SMCs), has been widely reported to be abnormally expressed in many solid tumors. However, the expression patterns of SM22 are not consistent in all tumors, not even in the same ones...
  2. Thweatt R, Lumpkin C, Goldstein S. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. Biochem Biophys Res Commun. 1992;187:1-7 pubmed
  3. Lawson D, Harrison M, Shapland C. Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines. Cell Motil Cytoskeleton. 1997;38:250-7 pubmed
    In this report we investigate the expression and relationship of transgelin (Tg), a transformation and shape-change sensitive actin gelling protein found in fibroblasts and smooth muscle [Shapland et al., 1988: J. Cell. Biol...
  4. Prasad P, Stanton J, Assinder S. Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer. Cell Tissue Res. 2010;339:337-47 pubmed publisher
    b>Transgelin is an actin-binding protein shown to be tumour-suppressive. Loss of transgelin expression in transformed cells is associated with oncogenesis...
  5. Dos Santos Hidalgo G, Meola J, Rosa e Silva J, Paro de Paz C, Ferriani R. TAGLN expression is deregulated in endometriosis and may be involved in cell invasion, migration, and differentiation. Fertil Steril. 2011;96:700-3 pubmed publisher
    We found an increased expression of the TAGLN gene in endometriotic lesions compared with the eutopic endometrium of the same patients by real-time polymerase chain reaction...
  6. Zhou L, Zhang R, Zhang L, Sun Y, Yao W, Zhao A, et al. Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer. Cancer Sci. 2013;104:423-30 pubmed publisher
    b>Transgelin is a known actin-binding protein, which plays a role in regulating the functions of smooth muscle cells or fibroblasts...
  7. Yamamura H, Masuda H, Ikeda W, Tokuyama T, Takagi M, Shibata N, et al. Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation. J Biochem. 1997;122:157-67 pubmed
    ..The results imply a novel mechanism for transcriptional control of the SMC differentiation-specific gene promoter. ..
  8. Camoretti Mercado B, Forsythe S, LeBeau M, Espinosa R, Vieira J, Halayko A, et al. Expression and cytogenetic localization of the human SM22 gene (TAGLN). Genomics. 1998;49:452-7 pubmed
    SM22 is a 22-kDa protein identified variously as SM22, transgelin, WS3-10, or mouse p27. Though its precise function is unknown, it is abundant in smooth muscle and so may contribute to the physiology of this widespread tissue...
  9. Shields J, Rogers Graham K, Der C. Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways. J Biol Chem. 2002;277:9790-9 pubmed
    ..We further characterized transgelin as a gene whose expression was abolished by Ras...

More Information

Publications107 found, 100 shown here

  1. Zhang R, Zhou L, Li Q, Liu J, Yao W, Wan H. Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia. Am J Respir Cell Mol Biol. 2009;41:467-75 pubmed publisher
    ..present study, we found, using a proteomics-based method, that gelsolin-like actin-capping protein (CapG) and transgelin were preferentially expressed in human (h)PAMSCs under hypoxia compared with normoxia...
  2. Lin Y, Buckhaults P, Lee J, Xiong H, Farrell C, Podolsky R, et al. Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer. Neoplasia. 2009;11:864-73 pubmed
    ..b>Transgelin, a 23-kDa actin-binding protein, emerged as a top-ranked candidate biomarker of node status...
  3. Lee E, Han G, Park H, Song Y, Kim C. Transgelin promotes migration and invasion of cancer stem cells. J Proteome Res. 2010;9:5108-17 pubmed publisher
    ..The expression level of Transgelin was 25-fold higher in tumorigenic cells than nontumorigenic cells...
  4. Zhang R, Shi L, Zhou L, Zhang G, Wu X, Shao F, et al. Transgelin as a therapeutic target to prevent hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014;306:L574-83 pubmed publisher
    We previously observed that transgelin was preferentially expressed in human pulmonary arterial smooth muscle cells (PAMSCs) under hypoxia and that the upregulation of transgelin was independent of hypoxia-inducible factor 1? (HIF-1?)...
  5. Yu H, Konigshoff M, Jayachandran A, Handley D, Seeger W, Kaminski N, et al. Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis. FASEB J. 2008;22:1778-89 pubmed publisher
    ..Here, we identified the transgelin (tagln) gene as a novel immediate target of TGF-beta/Smad3-dependent gene expression in ATII cells using a Smad3 ..
  6. Assinder S, Stanton J, Prasad P. Transgelin: an actin-binding protein and tumour suppressor. Int J Biochem Cell Biol. 2009;41:482-6 pubmed publisher
    b>Transgelin is a shape change sensitive 22 kDa actin-binding protein of the calponin family. It contains a C-terminal calponin-like module (CLIK(23)) and an upstream positively charged amino acid region required for actin binding...
  7. Zhao L, Wang H, Deng Y, Wang S, Liu C, Jin H, et al. Transgelin as a suppressor is associated with poor prognosis in colorectal carcinoma patients. Mod Pathol. 2009;22:786-96 pubmed publisher
    ..Among them, transgelin, a 22 kDa protein also called SM22, was identified as a novel tumor suppressor protein, but little is known ..
  8. Dvoráková M, Nenutil R, Bouchal P. Transgelins, cytoskeletal proteins implicated in different aspects of cancer development. Expert Rev Proteomics. 2014;11:149-65 pubmed publisher
    b>Transgelin is an abundant protein of smooth muscle cells, where its role has been primarily studied...
  9. McDaniel K, Meng F, Wu N, Sato K, Venter J, Bernuzzi F, et al. Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice‡. Hepatology. 2017;65:544-559 pubmed publisher
    ..Enhanced expression of FoxA2 was observed in BDL mouse liver after SMCC cell therapy...
  10. Schuliga M, Royce S, Langenbach S, Berhan A, Harris T, Keenan C, et al. The Coagulant Factor Xa Induces Protease-Activated Receptor-1 and Annexin A2-Dependent Airway Smooth Muscle Cytokine Production and Cell Proliferation. Am J Respir Cell Mol Biol. 2016;54:200-9 pubmed publisher
    ..mRNA for cytokines (IL-6), cell cycle-related protein (cyclin D1), and proremodeling proteins (FGF-2, PDGF-B, CTGF, SM22, and PAI-1) after 3-hour incubation (P < 0.05; n = 4)...
  11. Hashemi Gheinani A, Burkhard F, Rehrauer H, Aquino Fournier C, Monastyrskaya K. MicroRNA MiR-199a-5p regulates smooth muscle cell proliferation and morphology by targeting WNT2 signaling pathway. J Biol Chem. 2015;290:7067-86 pubmed publisher
    ..Overexpression of miR-199a-5p in the bladder SMCs significantly increased cell size and up-regulated SM22, SM α-actin, and SM myosin heavy chain mRNA and protein levels...
  12. Caraballo L, Coronado S. Parasite allergens. Mol Immunol. 2018;100:113-119 pubmed publisher
    ..Ani s 1, Ani s 4, Ani s 7 and Ani s 9; Necator americanus NaASP2q and Nacal1 and Schistosoma mansoni SmVAL4 and Sm22.6...
  13. Howard M, Greineder C, Hood E, Muzykantov V. Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation. J Control Release. 2014;177:34-41 pubmed publisher
    ..Both streptavidin-biotin and SATA/SMCC conjugation chemistries provided binding of 125-150 Ab molecules per liposome...
  14. Lin M, Chen T, Leaf E, Speer M, Giachelli C. Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice. Am J Pathol. 2015;185:1958-69 pubmed publisher
    ..SMC-specific deletion using SM22-recombinase transgenic allele mice (Runx2(ΔSM)) led to viable mice with normal bone and arterial morphology...
  15. Tsukada T, Isowa Y, Kito K, Yoshida S, Toneri S, Horiguchi K, et al. Identification of TGFβ-induced proteins in non-endocrine mouse pituitary cell line TtT/GF by SILAC-assisted quantitative mass spectrometry. Cell Tissue Res. 2019;376:281-293 pubmed publisher
    ..Upregulation of many pericyte markers (CSPG4, NES, ACTA, TAGLN, COL1A1, THBS1, TIMP3 and FLNA) supports our previous hypothesis that TGFβ reinforces pericyte properties...
  16. Zhang X, Liu J, Tang P, Liu Z, Guo G, Sun Q, et al. Identification of a New Uncompetitive Inhibitor of Adenosine Deaminase from Endophyte Aspergillus niger sp. Curr Microbiol. 2018;75:565-573 pubmed publisher
    ..We showed that compound 2 was a new uncompetitive inhibitor of ADA with high cytotoxic effect on HepG2 and SMCC-7721 cells (the IC50 values were 0.347 and 0.380 mM, respectively)...
  17. Yoshiyama S, Chen Z, Okagaki T, Kohama K, Nasu Kawaharada R, Izumi T, et al. Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type. Atherosclerosis. 2014;237:464-70 pubmed publisher
    ..63-fold), high-molecular-weight caldesmon (0.40-fold) and SM22 (0.66-fold), which concern differentiated VSMC, were decreased...
  18. Zou Y, Chen Z, Jennings B, Zhao G, Gu Q, Bhattacharya A, et al. Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation. Sci Rep. 2018;8:1468 pubmed publisher
    ..VSMC differentiation marker genes, including SMA and SM22, were downregulated in DGCR8 iKO mice. The majority of miRNAs were downregulated in DGCR8iKO mice...
  19. Kang H, Fan Y, Zhao P, Ren C, Wang Z, Deng X. Regional specific modulation of the glycocalyx and smooth muscle cell contractile apparatus in conduit arteries of tail-suspended rats. J Appl Physiol (1985). 2016;120:537-45 pubmed publisher
    ..The relative mRNA levels of syndecan-2, 3, 4, glypican-1, smooth muscle protein 22 (SM22), smoothelin (SMTN), and calponin were enhanced to 1.40, 1.53, 1.70, 1.90, 2.93, 2.30, and 5...
  20. Acosta A, Hamedani F, Meeks J, Wu S. Primary Ureteral Thyroid Transcription Factor 1-Positive Small Cell Neuroendocrine Carcinoma: Case Report and Review of the Literature. Int J Surg Pathol. 2015;23:472-7 pubmed publisher
    ..Recently, new chemotherapeutic regimens have shown some potential benefit for the treatment of urinary SmCC, albeit not achieving curative results...
  21. Cao Y, Matsubara T, Zhao C, Gao W, Peng L, Shan J, et al. Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment. Sci Rep. 2017;7:9307 pubmed publisher
    ..NNMT-ASO and ApoB-ASO are chemically conjugated with T3 using a non-cleavable sulfo-SMCC linker. Both NNMT-ASO-T3 (NAT3) and ApoB-ASO-T3 (AAT3) enhance thyroid hormone receptor activity...
  22. Li H, Qin X, Yang J, Ouyang C, Wu J, Jiang X, et al. Smooth muscle-specific LKB1 deletion exaggerates angiotensin II-induced abdominal aortic aneurysm in mice. J Mol Cell Cardiol. 2019;130:131-139 pubmed publisher
    ..muscle-specific LKB1 (LKB1SMKO) were generated by cross-breeding LKB1flox/flox mice with SM22-CreERT2 transgenic mice and induced in adult mice by tamoxifen treatment...
  23. Hibino N, Cismowski M, Lilly B, McConnell P, Shinoka T, Cheatham J, et al. Potential Molecular Mechanism of Retrograde Aortic Arch Stenosis in the Hybrid Approach to Hypoplastic Left Heart Syndrome. Ann Thorac Surg. 2015;100:1013-9; discussion 1019-20 pubmed publisher
    ..VSMC differentiation markers (β-actin, SM22, and calponin) and signaling pathways for VSMC modulation (transforming growth factor-β1, Notch, and platelet ..
  24. Zhang Q, Yue X, Jiang Y, Han T, Xin H. FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells. Sci Rep. 2017;7:396 pubmed publisher
    ..Ectopic expression of FAM46C in two HCC cell lines, SMCC-7721 and SK-Hep-1, significantly repressed cell proliferation, and increased cells population in G2/M phase and ..
  25. Tang D, Chen Y, He H, Huang J, Chen W, Peng W, et al. Integrated analysis of mRNA, microRNA and protein in systemic lupus erythematosus-specific induced pluripotent stem cells from urine. BMC Genomics. 2016;17:488 pubmed publisher
    ..Western blot and Q-PCR confirmed AK4 protein and mRNA up-regulation. The findings also showed that TAGLN's protein and mRNA level were down-regulated in SLE-iPSCs, both miR-371a-5p and let-7a-5p in SLE-iPSC were down-..
  26. Shudo Y, Cohen J, Goldstone A, Macarthur J, Patel J, Edwards B, et al. Isolation and trans-differentiation of mesenchymal stromal cells into smooth muscle cells: Utility and applicability for cell-sheet engineering. Cytotherapy. 2016;18:510-7 pubmed publisher
    ..3?±?6.9%, FN 65.1?±?6.5%, LM 59.3?±?7.0%, Control 39.9?±?3.1%; P?=?0.02, SM22; Col IV 56.0?±?7.7%, FN 74.2?±?6.7%, LM 60.4?±?8.7%, Control 44.9?±?3...
  27. Limmer F, Schinner E, Castrop H, Vitzthum H, Hofmann F, Schlossmann J. Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration. FEBS J. 2015;282:3786-98 pubmed publisher
    ..cGKIα-rescue mice expressed cGKIα only under the control of the smooth muscle-specific transgelin (SM22) promoter in a cGKI deficient background...
  28. Chen X, Howatt D, Balakrishnan A, Moorleghen J, Wu C, Cassis L, et al. Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis-Brief Report. Arterioscler Thromb Vasc Biol. 2016;36:1085-9 pubmed publisher
    ..ACE was depleted from SMCs by breeding female ACE floxed mice with male SM22-Cre transgenic mice...
  29. Lu C, Liu M, Clinton M, Culshaw G, Argyle D, Corcoran B. Developmental pathways and endothelial to mesenchymal transition in canine myxomatous mitral valve disease. Vet J. 2015;206:377-84 pubmed publisher
    ..basement membrane disarray (NID1, LAMA2 and CTSS), mesenchymal and endothelial cell differentiation (MYH11 and TAGLN) and EndoMT (ACTA2, SNAI1, CTNNB1, HAS2, CDH5, and NOTCH1), with fold changes from +15.35 (ACTA2) to -5.52 (LAMA2)...
  30. Chen J, Xu L, Fang W, Han J, Wang K, Zhu K. Identification of PA28β as a potential novel biomarker in human esophageal squamous cell carcinoma. Tumour Biol. 2017;39:1010428317719780 pubmed publisher
    ..Compared to their expression in the adjacent normal epithelia, 12 proteins, including transgelin (TAGLN), were upregulated in ESCC tissues; 17 proteins, including proteasome activator 28-beta subunit (PA28β), ..
  31. Hu D, Mohanta S, Yin C, Peng L, Ma Z, Srikakulapu P, et al. Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β Receptors. Immunity. 2015;42:1100-15 pubmed publisher
    ..Atherosclerosis was markedly exacerbated in Apoe(-/-)Ltbr(-/-) and to a similar extent in aged Apoe(-/-)Ltbr(fl/fl)Tagln-cre mice...
  32. Kim T, Lee H, Lee S, Kim E, Kim K, Paik S, et al. SM22?-induced activation of p16INK4a/retinoblastoma pathway promotes cellular senescence caused by a subclinical dose of ?-radiation and doxorubicin in HepG2 cells. Biochem Biophys Res Commun. 2010;400:100-5 pubmed publisher
    Smooth muscle protein 22-alpha (SM22?) is known as a transformation- and shape change-sensitive actin cross-linking protein found in smooth muscle tissue and fibroblasts; however, its functional role remains uncertain...
  33. Cheng S, Ramachandran B, Behrmann A, Shao J, Mead M, Smith C, et al. Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals. Circ Res. 2015;117:142-56 pubmed publisher
    Wnt signaling regulates key aspects of diabetic vascular disease. We generated SM22-Cre;LRP6(fl/fl);LDLR(-/-) mice to determine contributions of Wnt coreceptor low-density lipoprotein receptor-related protein 6 (LRP6) in the vascular ..
  34. Correia A, Moonen J, Brinker M, Krenning G. FGF2 inhibits endothelial-mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-β signaling. J Cell Sci. 2016;129:569-79 pubmed publisher
    ..endothelial sprouting capacity and induces the expression of the mesenchymal marker SM22α (also known as TAGLN). We identified ALK5 (also known as TGFBR1), TGFBR2 and SARA (also known as ZFYVE9) as direct miR-20a targets...
  35. Shu Y, Zhang F, Bi W, Dong L, Zhang D, Chen R, et al. SM22α inhibits vascular inflammation via stabilization of IκBα in vascular smooth muscle cells. J Mol Cell Cardiol. 2015;84:191-9 pubmed publisher
    Smooth muscle (SM) 22α, an actin-binding protein, is down-regulated in atherosclerotic arteries. Disruption of SM22α promotes arterial inflammation through activation of reactive oxygen species (ROS)-mediated nuclear factor (NF)-κ..
  36. Croner R, Sevim M, Metodiev M, Jo P, Ghadimi M, Schellerer V, et al. Identification of Predictive Markers for Response to Neoadjuvant Chemoradiation in Rectal Carcinomas by Proteomic Isotope Coded Protein Label (ICPL) Analysis. Int J Mol Sci. 2016;17:209 pubmed publisher
    ..The protein expression of regulated proteins such as PLEC1, TKT, HADHA and TAGLN was validated successfully by immunohistochemistry...
  37. Vizlin Hodzic D, Zhai Q, Illes S, Södersten K, Truvé K, Parris T, et al. Early onset of inflammation during ontogeny of bipolar disorder: the NLRP2 inflammasome gene distinctly differentiates between patients and healthy controls in the transition between iPS cell and neural stem cell stages. Transl Psychiatry. 2017;7:e1010 pubmed publisher
    ..addition, we have also identified several cytoskeleton-associated genes as DEGs from the NSC stage, such as TMP2, TAGLN and ACTA2; the former two genes are recognised for the first time to be associated with BD...
  38. Edgington R, Spillane K, Papageorgiou G, Wray W, Ishiwata H, Labarca M, et al. Functionalisation of Detonation Nanodiamond for Monodispersed, Soluble DNA-Nanodiamond Conjugates Using Mixed Silane Bead-Assisted Sonication Disintegration. Sci Rep. 2018;8:728 pubmed publisher
    ..using the heterobifunctional crosslinker sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfo-SMCC)...
  39. Singh J, Boopathi E, Addya S, Phillips B, Rigoutsos I, Penn R, et al. Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a. Am J Physiol Gastrointest Liver Physiol. 2016;311:G964-G973 pubmed publisher
    ..of multiple, predicted targets (Eln, Col3a1, Col1a1, Zeb2, Myocd, Srf, Smad1, Smad2, Rhoa/Rock2, Fn1, Tagln v2, Klf4, and Acta2) involved in regulation of smooth muscle contractility...
  40. Zhou H, Fang Y, Weinberger P, Ding L, Cowell J, Hudson F, et al. Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility. BMC Cancer. 2016;16:55 pubmed publisher
    b>Transgelin is an actin-binding protein that promotes motility in normal cells...
  41. Singh R, Setiady Y, Ponte J, Kovtun Y, Lai K, Hong E, et al. A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells. Mol Cancer Ther. 2016;15:1311-20 pubmed publisher
    ..molecule (anti-EpCAM) and anti-EGFR antibodies with maytansinoid payloads were prepared using CX or a noncleavable SMCC linker (CX and SMCC ADCs)...
  42. Lv P, Miao S, Shu Y, Dong L, Liu G, Xie X, et al. Phosphorylation of smooth muscle 22? facilitates angiotensin II-induced ROS production via activation of the PKC?-P47phox axis through release of PKC? and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cel. Circ Res. 2012;111:697-707 pubmed publisher
    ..The recent study indicates that SM22? disruption can independently promote arterial inflammation through activation of reactive oxygen species (ROS)-..
  43. Singh N, Sreenivas V, Sheoran A, Sharma S, Gupta K, Khuller G, et al. Serodiagnostic potential of immuno-PCR using a cocktail of mycobacterial antigen 85B, ESAT-6 and cord factor in tuberculosis patients. J Microbiol Methods. 2016;120:56-64 pubmed publisher
    ..anti-human IgG antibody through a chemical linker succinimidyl 4-[N-maleimidomethyl]-cyclohexane-1-carboxylate (SMCC)...
  44. Yan L, Shi G. [Effect of IFN-α on hepatic cancer SMCC-7721 cell via PI3K/Akt signaling pathway and related mechanism research]. Zhonghua Yi Xue Za Zhi. 2015;95:2960-3 pubmed
    This study explored how interferon alpha (IFN-α) influenced liver cancer SMCC-7721 cell via PI3K/Akt signaling pathway. The effect of IFN-α on the viability of SMCC-7721 cell was measured by MTT assay...
  45. Kim M, Shin S, Lim C, Kim J, Um S, Kim D. Polyaspartamide-based graft copolymers encapsulating iron oxide nanoparticles for imaging and fluorescence labelling of immune cells. Biomater Sci. 2017;5:305-312 pubmed publisher
    ..EA), ethylenediamine (EDA), 4-(N-maleimidomethyl) cyclohexane carboxylic acid N-hydroxysuccinimide ester (SMCC), and fluorescein isothiocyanate (FITC) was coated on the iron oxide NPs...
  46. Komersová A, Lochař V, Myslíková K, Mužíková J, Bartos M. Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders. Eur J Pharm Sci. 2016;95:36-45 pubmed publisher
    ..Methocel™ K4M Premium CR or Methocel™ K100M Premium CR were used as controlled release agents and Prosolv® SMCC 90 or Disintequik™ MCC 25 were used as co-processed dry binders...
  47. Xia K, Zhang P, Hu J, Hou H, Xiong M, Xiong J, et al. Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells. Oncol Lett. 2018;15:4344-4350 pubmed publisher
    ..The present study aimed to investigate whether simvastatin (SV) is able to induce SMCC-7721 cell apoptosis through the Wnt/β-catenin signaling pathway...
  48. HNASKO R. Bioconjugation of Antibodies to Horseradish Peroxidase (HRP). Methods Mol Biol. 2015;1318:43-50 pubmed publisher
    ..In this chapter, we describe a process by which Sulfo-SMCC is used to generate a stable maleimide-activated HRP that is reactive with sulfhydryl groups generated in ..
  49. Wang K, Li Y, Shi G, Tsai H, Luo C, Cheng M, et al. Membrane-Bound Thrombomodulin Regulates Macrophage Inflammation in Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2015;35:2412-22 pubmed publisher
    ..TM in vivo, transgenic mice with myeloid- (LysMcre/TM(flox/flox)) and vascular smooth muscle cell-specific (SM22-cre(tg)/TM(flox/flox)) TM ablation and their respective wild-type controls (TM(flox/flox) and SM22-cre(tg)/TM(+/+)) ..
  50. Zhang J, Link D. Targeting of Mesenchymal Stromal Cells by Cre-Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells. J Bone Miner Res. 2016;31:2001-2007 pubmed publisher
    ..Finally, we introduce a new tissue-specific Cre-recombinase, Tagln-Cre, which efficiently targets osteoblasts, a majority of CAR cells, and both venous sinusoidal and arteriolar ..
  51. Maleszewska M, Gjaltema R, Krenning G, Harmsen M. Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22α expression in endothelial cells in response to interleukin-1β and transforming growth factor-β2. Cell Signal. 2015;27:1589-96 pubmed publisher
    Smooth muscle-22α (SM22α), encoded by transgelin (TAGLN), is expressed in mesenchymal lineage cells, including myofibroblasts and smooth muscle cells...
  52. Yuan Y, Shi Y, Li C, Kim J, Cai W, Han Z, et al. DeepGene: an advanced cancer type classifier based on deep learning and somatic point mutations. BMC Bioinformatics. 2016;17:476 pubmed publisher
    ..cancer types/subtypes, which may contribute to more accurate somatic point mutation based cancer classification (SMCC)...
  53. Palacios M, Tampe R, del Campo M, Zhong T, López M, Salazar Onfray F, et al. Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside. Eur J Med Chem. 2018;150:74-86 pubmed publisher
    ..obtained from Concholepas concholepas (CCH) and Fissurella latimarginata (FLH), coupled through sulfo-SMCC to P10, a mimetic peptide of GD2, the major ganglioside constituent of neuroectodermal tumors, and incorporating ..
  54. Liao X, Li S, Lou Z, Chen Z, Bartlam M. Crystallization and preliminary crystallographic analysis of transgelin. Protein Pept Lett. 2007;14:209-11 pubmed
    b>Transgelin was solubly expressed in E. coli. Crystals of transgelin have been grown at 291K using sodium formate or PEG-4000 as precipitants. X-ray diffraction by the crystal extends to 2.3 A resolution...
  55. Gerolymos M, Karagianni F, Papasotiriou M, Kalliakmani P, Sotsiou F, Charonis A, et al. Expression of transgelin in human glomerulonephritis of various etiology. Nephron Clin Pract. 2011;119:c74-82 pubmed publisher
    Activation of myofibroblasts occurs during kidney injury. Genomic and proteomic studies suggest that transgelin represents a protein that may be involved in renal injury...
  56. Fan H, Lu P, Xu L, Qin Y, Li J. Synchronous occurrence of hereditary gastric adenocarcinoma, gastrointestinal stromal tumor, and esophageal small cell and squamous carcinoma in situ: an extremely rare case report. BMC Cancer. 2017;17:720 pubmed publisher
    ..Small-cell carcinoma (SmCC) is a rare histological type of esophageal carcinoma, accounting for 0.4% to 2.8% of all esophageal tumors...
  57. Xu R, Ho Y, Ritchie R, Li L. Human SM22 alpha BAC encompasses regulatory sequences for expression in vascular and visceral smooth muscles at fetal and adult stages. Am J Physiol Heart Circ Physiol. 2003;284:H1398-407 pubmed
    The SM22 alpha gene has widely been used to study the regulatory mechanisms of smooth muscle cell (SMC) gene expression during cardiovascular development...
  58. Li M, Li S, Lou Z, Liao X, Zhao X, Meng Z, et al. Crystal structure of human transgelin. J Struct Biol. 2008;162:229-36 pubmed publisher
    b>Transgelin (TAGLN), also known as smooth muscle protein 22 (SM22), is a highly conserved protein found in smooth muscle tissues of adult vertebrates...
  59. Kim T, Moon J, Lee H, Cho E, Paik S, Kim I. SM22alpha inhibits cell proliferation and protects against anticancer drugs and gamma-radiation in HepG2 cells: involvement of metallothioneins. FEBS Lett. 2009;583:3356-62 pubmed publisher
    ..This study provides the first demonstration of SM22alpha-induced blockage of cell proliferation and cellular resistance to overcome the detrimental effects of damaging agents. ..
  60. Rho J, Roehrl M, Wang J. Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma. J Proteome Res. 2009;8:5610-8 pubmed publisher
    ..From these candidate spots, three proteins overexpressed in cancer were identified by mass spectrometry as transgelin (TAGLN, SM22-alpha, WS3-10), transgelin-2 (TAGLN2), and cyclophilin A (PPIA)...
  61. Kim T, Cho E, Paik S, Kim I. Hypoxia-induced SM22? in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy. FEBS Lett. 2012;586:303-9 pubmed publisher
    ..Thus, therapies that overcome cellular resistance during hypoxia are necessary. SM22? is an actin-binding protein found in smooth muscle, fibroblasts, and some epithelium...
  62. Xie X, Liu Y, Liu Y, Du B, Li Y, Han M, et al. Reduced expression of SM22 is correlated with low autophagy activity in human colorectal cancer. Pathol Res Pract. 2013;209:237-43 pubmed publisher
    ..Recent studies have pointed to deregulation of autophagy as a novel pathogenesis of human malignancy. SM22 is considered as a tumor suppressor...
  63. Sahasrabuddhe N, Barbhuiya M, Bhunia S, Subbannayya T, Gowda H, Advani J, et al. Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics. Biochem Biophys Res Commun. 2014;446:863-9 pubmed publisher
    ..Downregulated proteins included serine protease HTRA1 and transgelin, which have been reported to be downregulated in several other cancers...
  64. Bu J, Bu X, Liu B, Chen F, Chen P. Increased Expression of Tissue/Salivary Transgelin mRNA Predicts Poor Prognosis in Patients with Oral Squamous Cell Carcinoma (OSCC). Med Sci Monit. 2015;21:2275-81 pubmed publisher
    b>Transgelin is supposed to be a tumor suppression gene and it is down-regulated in a variety of human cancers. However, the role of transgelin in different cancers is still very controversial...
  65. Yang Z, Chang Y, Miyamoto H, Ni J, Niu Y, Chen Z, et al. Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth. Mol Endocrinol. 2007;21:343-58 pubmed
    ..Here we describe transgelin as the first ARA54-associated negative modulator for AR...
  66. Leguillette R, Laviolette M, Bergeron C, Zitouni N, Kogut P, Solway J, et al. Myosin, transgelin, and myosin light chain kinase: expression and function in asthma. Am J Respir Crit Care Med. 2009;179:194-204 pubmed publisher
    ..We observed an increased expression of the fast myosin heavy chain isoform, transgelin, and myosin light chain kinase in patients with asthma...
  67. Middelberg R, Ferreira M, Henders A, Heath A, Madden P, Montgomery G, et al. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. BMC Med Genet. 2011;12:123 pubmed publisher
    ..Our study demonstrated the usefulness of examining multiple phenotypes jointly and highlights an anomalous effect on CRP, which is increasingly recognised as a marker of cardiovascular risk as well as of inflammation. ..
  68. Thompson O, Moghraby J, Ayscough K, Winder S. Depletion of the actin bundling protein SM22/transgelin increases actin dynamics and enhances the tumourigenic phenotypes of cells. BMC Cell Biol. 2012;13:1 pubmed publisher
    b>SM22 has long been studied as an actin-associated protein...
  69. Elsner M, Rauser S, Maier S, Schöne C, Balluff B, Meding S, et al. MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma. J Proteomics. 2012;75:4693-704 pubmed publisher
    ..This article is part of a Special Issue entitled: Translational Proteomics. ..
  70. Robin Y, Penel N, Pérot G, Neuville A, Velasco V, Ranchere Vince D, et al. Transgelin is a novel marker of smooth muscle differentiation that improves diagnostic accuracy of leiomyosarcomas: a comparative immunohistochemical reappraisal of myogenic markers in 900 soft tissue tumors. Mod Pathol. 2013;26:502-10 pubmed publisher
    ..were evaluated (smooth muscle actin, desmin, h-caldesmon and calponin), and compared with a novel marker, transgelin. The diagnostic performance of each marker was statistically assessed in terms of sensitivity (Se), specificity (..
  71. Rao D, Kimler B, Nothnick W, Davis M, Fan F, Tawfik O. Transgelin: a potentially useful diagnostic marker differentially expressed in triple-negative and non-triple-negative breast cancers. Hum Pathol. 2015;46:876-83 pubmed publisher
    ..For the remainder, identification of target markers for effective treatment strategies remains a challenge. Transgelin (TGLN) is a 22-kd actin-binding protein of the calponin family...
  72. Li Y, He Q, Hu X, Liu Y, Cheng X, Li X, et al. Improved performance of collagen scaffolds crosslinked by Traut's reagent and Sulfo-SMCC. J Biomater Sci Polym Ed. 2017;28:629-647 pubmed publisher
    ..In previous studies, we affirmed that Traut's reagent (2-Iminothiolane hydrochloride) and Sulfo-SMCC (4-(N-Maleimidomethyl) cyclohexane-1-carboxylic acid 3-sulpho-N-hydroxysuccinimide ester sodium salt) could ..
  73. Schellekens D, Reisinger K, Lenaerts K, Hadfoune M, Olde Damink S, Buurman W, et al. SM22 a Plasma Biomarker for Human Transmural Intestinal Ischemia. Ann Surg. 2018;268:120-126 pubmed publisher
    To evaluate the diagnostic potential of smooth muscle protein of 22?kDa (SM22) as plasma biomarker for the detection of transmural intestinal ischemia...
  74. Li Y, Run L, Shi T, Zhang Y. CTRP9 regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and migration via TGF-?1/ERK1/2 signaling pathway. Biochem Biophys Res Commun. 2017;490:1319-1325 pubmed publisher
    ..augmented hypoxia-mediated differentiation by elevating the expression level of differentiation markers ?-SMA and SM22. Mechanistically, anti-proliferative effects conferred by CTRP9 are mediated through suppression of TGF-?1/ERK1/2 ..
  75. Li L, Liu Z, Mercer B, Overbeek P, Olson E. Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells. Dev Biol. 1997;187:311-21 pubmed
  76. Chen Q, Gu Y, Zhou C, Hu L, Peng C. [Expression of Calponin-1 and Transgelin in human uterine smooth muscles in non-labor and labor situation]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35:1073-9 pubmed publisher
    ..Immunohistochemical technology and Western blot were used to determine the expression of Calponin-1 and Transgelin in the 2 groups...
  77. Fehrholz M, Speer C, Kunzmann S. Caffeine and rolipram affect Smad signalling and TGF-?1 stimulated CTGF and transgelin expression in lung epithelial cells. PLoS ONE. 2014;9:e97357 pubmed publisher
    ..Connective tissue growth factor (CTGF), a downstream mediator of TGF-?, and transgelin, a binding and stabilising protein of the cytoskeleton, are both regulated by TGF-?1 and play an important role ..
  78. Zhao M, Huang J, Gui K, Xiong M, Cai G, Xu J, et al. The downregulation of miR-144 is associated with the growth and invasion of osteosarcoma cells through the regulation of TAGLN expression. Int J Mol Med. 2014;34:1565-72 pubmed publisher
    ..We identified TAGLN as a downstream target of miR-144 and demonstrated that its expression is upregulated in osteosarcoma cell lines ..
  79. Xie X, Nie X, Wu J, Zhang F, Zhao L, Lin Y, et al. Smooth muscle 22α facilitates angiotensin II-induced signaling and vascular contraction. J Mol Med (Berl). 2015;93:547-58 pubmed publisher
    Smooth muscle 22α (SM22α) is involved in stress fiber formation and enhances contractility in vascular smooth muscle cells (VSMCs)...
  80. Zhang Y, Liao R, Li H, Liu L, Chen X, Chen H. Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma. Med Sci Monit. 2015;21:2659-65 pubmed publisher
    ..Immunohistochemical streptavidin-peroxidase method was used to determine the expressions of Cofilin-1 and transgelin in 68 patients with esophageal squamous cell carcinoma (ESCC) and 48 individuals with normal esophageal tissues...
  81. Webber J, Spary L, Mason M, Tabi Z, Brewis I, Clayton A. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget. 2016;7:20124-39 pubmed publisher
    ..Proteomics highlighted disease-related cytoskeleton alterations such as elevated Transgelin (TAGLN)...
  82. Uynuk Ool T, Rothdiener M, Walters B, Hegemann M, Palm J, Nguyen P, et al. The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces. J Tissue Eng Regen Med. 2017;11:3508-3522 pubmed publisher
    ..was measured by atomic force microscopy and the expression of smooth muscle cell (SMC) marker genes (ACTA2, TAGLN, CNN1) by quantitative reverse-transcription polymerase chain reaction. Cyclic stretch was applied with 2...
  83. Neethu B, Ghangrekar M. Electricity generation through a photo sediment microbial fuel cell using algae at the cathode. Water Sci Technol. 2017;76:3269-3277 pubmed publisher
    ..Sediment microbial carbon-capture cell (SMCC), a modified SMFC, uses algae grown in the overlying water of sediment and is considered as a promising system for ..
  84. Chainiaux F, Magalhaes J, Eliaers F, Remacle J, Toussaint O. UVB-induced premature senescence of human diploid skin fibroblasts. Int J Biochem Cell Biol. 2002;34:1331-9 pubmed
    ..Third, the steady-state level of the mRNA of three senescence-associated genes, i.e. fibronectin, osteonectin and SM22, was increased in HDFs at 72 h after three and five exposures to UVB...
  85. Yeo M, Park H, Kim D, Kim Y, Cheong J, Lee K, et al. Loss of SM22 is a characteristic signature of colon carcinogenesis and its restoration suppresses colon tumorigenicity in vivo and in vitro. Cancer. 2010;116:2581-9 pubmed publisher
    We previously found the down-expression of SM22 in an experimental animal model of colorectal cancer by performing a proteomic analysis...
  86. Lisitskaia K, Krakhmaleva I, Shishkin S. [A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]. Mol Gen Mikrobiol Virusol. 2010;:34-7 pubmed
    ..for allele discrimination, we examined nine known SNPs in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer (PC)...
  87. Dong L, Lv P, Han M. Roles of SM22? in cellular plasticity and vascular diseases. Cardiovasc Hematol Disord Drug Targets. 2012;12:119-25 pubmed
    b>SM22? is a shape change and transformation sensitive 22 kDa actin-binding protein of the calponin family. It is ubiquitous to vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation...
  88. Shi X, Guo L, Seedial S, Takayama T, Wang B, Zhang M, et al. Local CXCR4 Upregulation in the Injured Arterial Wall Contributes to Intimal Hyperplasia. Stem Cells. 2016;34:2744-2757 pubmed publisher
    ..It remains unknown, however, whether locally induced CXCR4 expression in SM22 expressing vascular SMCs plays a role in neointima formation...
  89. Mitarai H, Wada N, Hasegawa D, Yoshida S, Sonoda M, Tomokiyo A, et al. Transgelin mediates transforming growth factor-?1-induced proliferation of human periodontal ligament cells. J Periodontal Res. 2017;52:984-993 pubmed publisher
    ..b>Transgelin is a cytoskeleton-associated protein with an Smad-binding element in its gene promoter region...
  90. Meng T, Liu L, Hao R, Chen S, Dong Y. Transgelin-2: A potential oncogenic factor. Tumour Biol. 2017;39:1010428317702650 pubmed publisher
    ..As a member of actin-binding proteins, Transgelin-2 is expressed in smooth muscle cells and non-smooth muscle cells, and its gene, TAGLN2, is differently ..
  91. Aarup A, Nielsen C, Bisgaard L, Bot I, El Ali H, Kjaer A, et al. Uremia does not affect neointima formation in mice. Sci Rep. 2017;7:6496 pubmed publisher
    ..e., myocardin, α-smooth muscle actin, SM22-alpha, and smooth muscle myosin heavy chain) in both wt and Apoe -/- mice...
  92. Liu R, Hossain M, Chen X, Jin J. Mechanoregulation of SM22?/Transgelin. Biochemistry. 2017;56:5526-5538 pubmed publisher
    SM22?, also named transgelin, is an actin filament-associated protein in smooth muscle and fibroblasts. Three decades after its discovery, the biological function of SM22? remains under investigation...