Gene Symbol: TACR1
Description: tachykinin receptor 1
Alias: NK1R, NKIR, SPR, TAC1R, substance-P receptor, NK-1 receptor, NK-1R, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
Species: human
Products:     TACR1

Top Publications

  1. Fong T, Anderson S, Yu H, Huang R, Strader C. Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. Mol Pharmacol. 1992;41:24-30 pubmed
    ..These results indicate that multiple forms of the human neurokinin-1 receptor exist and the differential activation of intracellular effector may be involved in generating the complex biological effects of substance P. ..
  2. Lequin O, Bolbach G, Frank F, Convert O, Girault Lagrange S, Chassaing G, et al. Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P. Photoaffinity labeling and modeling studies. J Biol Chem. 2002;277:22386-94 pubmed
  3. Seneviratne C, Ait Daoud N, Ma J, Chen G, Johnson B, Li M. Susceptibility locus in neurokinin-1 receptor gene associated with alcohol dependence. Neuropsychopharmacology. 2009;34:2442-9 pubmed publisher
    ..Substance P (SP), a neurotransmitter in stress pathways, exerts its effects mainly through the neurokinin-1 receptor (NK1R)...
  4. De Felipe C, Herrero J, O Brien J, Palmer J, Doyle C, Smith A, et al. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature. 1998;392:394-7 pubmed
  5. Caberlotto L, Hurd Y, Murdock P, Wahlin J, Melotto S, Corsi M, et al. Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain. Eur J Neurosci. 2003;17:1736-46 pubmed
  6. Randolph G, Simon J, Arreaza M, Qiu P, Lachowicz J, Duffy R. Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant. Pharmacogenomics J. 2004;4:394-402 pubmed
    ..In all cases the Y192H variant was found to display properties similar to those of the wild-type receptor. ..
  7. Giegling I, Rujescu D, Mandelli L, Schneider B, Hartmann A, Schnabel A, et al. Tachykinin receptor 1 variants associated with aggression in suicidal behavior. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:757-61 pubmed
    ..We studied gene variants of Tachykinin Receptor 1 (TACR1-rs3771810, rs3771825, rs726506, rs1477157) in 167 German suicide attempters (affective spectrum n = 107, ..
  8. Perlis R, Purcell S, Fagerness J, Kirby A, Petryshen T, Fan J, et al. Family-based association study of lithium-related and other candidate genes in bipolar disorder. Arch Gen Psychiatry. 2008;65:53-61 pubmed publisher
    ..Recent developments suggest that a broader pool of genes may be associated with this disorder...
  9. Yan T, McQuillin A, Thapar A, Asherson P, Hunt S, Stanford S, et al. NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. J Psychopharmacol. 2010;24:27-38 pubmed publisher
    Mice with functional genetic ablation of the Tacr1 (substance P-preferring receptor) gene (NK1R-/-) are hyperactive...

More Information

Publications125 found, 100 shown here

  1. Chandra P, Hafizi S, Massey Chase R, Goodwin G, Cowen P, Harmer C. NK1 receptor antagonism and emotional processing in healthy volunteers. J Psychopharmacol. 2010;24:481-7 pubmed publisher
    ..Human models of emotional processing may provide a useful means of assessing the likely therapeutic potential of new treatments for depression. ..
  2. Blaine S, Claus E, Harlaar N, Hutchison K. TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence. Alcohol Clin Exp Res. 2013;37 Suppl 1:E125-30 pubmed publisher
    The tachykinin receptor 1 (TACR1) gene is a promising candidate gene in the search for the genetic basis of alcohol dependence (AD); TACR1 antagonists improve symptomology not only in preclinical models of AD but also in a clinical ..
  3. Page N, Bell N, Gardiner S, Manyonda I, Brayley K, Strange P, et al. Characterization of the endokinins: human tachykinins with cardiovascular activity. Proc Natl Acad Sci U S A. 2003;100:6245-50 pubmed
    ..Thus, EKA/B could be the endocrineparacrine agonists at peripheral SP receptors and there may be as yet an unidentified receptor(s) for EKC/D. ..
  4. Andersson G, Danielson P, Alfredson H, Forsgren S. Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon. Regul Pept. 2008;150:81-7 pubmed publisher
    ..In conclusion, it appears as if SPergic autocrine/paracrine effects occur in tendon tissue during the processes of tendinosis, hitherto unknown effects for human tendons. ..
  5. Hodges L, Weissman M, Haghighi F, Costa R, Bravo O, Evgrafov O, et al. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:65-73 pubmed publisher
    ..The genes encoding corticotropin releasing hormone receptor 1 (CRHR1), tachykinin receptor 1 (TACR1), gastrin releasing peptide (GRP), and gastrin releasing peptide receptor (GRPR) were selected as candidates for ..
  6. Lai J, Lai S, Tuluc F, Tansky M, Kilpatrick L, Leeman S, et al. Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor. Proc Natl Acad Sci U S A. 2008;105:12605-10 pubmed publisher
    The neurokinin-1 receptor (NK1R) has two naturally occurring forms that differ in the length of the carboxyl terminus: a full-length receptor consisting of 407 aa and a truncated receptor consisting of 311 aa...
  7. McCabe C, Cowen P, Harmer C. NK1 receptor antagonism and the neural processing of emotional information in healthy volunteers. Int J Neuropsychopharmacol. 2009;12:1261-74 pubmed publisher
    ..Such findings confirm animal studies which support a role for NK1 receptors in emotion. Such an approach may be useful in understanding the effects of novel drug treatments prior to full-scale clinical trials. ..
  8. Linnman C, Appel L, Furmark T, Söderlund A, Gordh T, Langstrom B, et al. Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain. Pain. 2010;149:64-70 pubmed publisher
    ..We conclude that the central NK1 receptor system is altered in human chronic pain. The results suggest that NK1 receptors in the vmPFC modulate motor inhibition, and contribute to fear and avoidance of movement. ..
  9. Berger M, Neth O, Ilmer M, Garnier A, Salinas Martín M, de Agustín Asencio J, et al. Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo. J Hepatol. 2014;60:985-94 pubmed publisher
    ..The substance P (SP)/neurokinin-1 receptor (NK1R) complex has been discovered to be pivotal in the development of a variety of human cancers, and NK1R antagonists, ..
  10. de Croft S, Boehm U, Herbison A. Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse. Endocrinology. 2013;154:2750-60 pubmed publisher
    ..However, the effects of NKB result from an unexpected activation of multiple tachykinin receptors. ..
  11. Gleason N, Gallos G, Zhang Y, Emala C. Propofol preferentially relaxes neurokinin receptor-2-induced airway smooth muscle contraction in guinea pig trachea. Anesthesiology. 2010;112:1335-44 pubmed publisher
  12. Barson J, Poon K, Ho H, Alam M, Sanzalone L, Leibowitz S. Substance P in the anterior thalamic paraventricular nucleus: promotion of ethanol drinking in response to orexin from the hypothalamus. Addict Biol. 2017;22:58-69 pubmed publisher
    ..ethanol drinking, similar to OX, and that SP receptor [neurokinin 1 receptor/tachykinin receptor 1 (NK1R)] antagonists in this subregion reduce ethanol drinking...
  13. Jobling P, Messenger J, Gibbins I. Differential expression of functionally identified and immunohistochemically identified NK(1) receptors on sympathetic neurons. J Neurophysiol. 2001;85:1888-98 pubmed
    ..Responses evoked by SP and senktide were resistant to PKC inhibitors, suggesting that the transduction mechanisms for the NK(1)-like receptor and the NK(3) receptor may be similar...
  14. Martinez A, Burmeister A, Ramesh G, Doyle Meyers L, Marriott I, Philipp M. Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis. J Neuroinflammation. 2017;14:37 pubmed publisher
    ..burgdorferi-associated neuroinflammatory responses and sequelae raises the intriguing possibility that such FDA-approved agents could be repurposed for use as an adjunctive therapy for the treatment of bacterial CNS infections. ..
  15. Wang G, Wang X, Liu S, Qu M, Xia Y, Needleman B, et al. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol. 2014;307:G719-31 pubmed publisher
  16. Levick S, Brower G, Janicki J. Substance P-mediated cardiac mast cell activation: An in vitro study. Neuropeptides. 2019;74:52-59 pubmed publisher
    ..That the response to substance P is receptor mediated and can be modulated by activation of other receptors (PPAR-γ), argues that substance P activation of cardiac mast cells has potential biological significance. ..
  17. Kaur J, Sharma S, Sandhu M, Sharma S. Neurokinin-1 receptor inhibition reverses ischaemic brain injury and dementia in bilateral common carotid artery occluded rats: possible mechanisms. Inflammopharmacology. 2016;24:133-43 pubmed publisher
    ..However, BADGE (30 mg/kg a, PPAR-? antagonist) prevented the ameliorative effect of aprepitant. Thus, it may be concluded that aprepitant attenuates vascular dysfunction and dementia in BCCAO rats by activating downstream PPAR-?. ..
  18. Munoz M, Recio S, Rosso M, Redondo M, Covenas R. The antiproliferative action of [D-Arg(1), D-Phe(5), D-Trp(7,9), LEU(11)] substance P analogue antagonist against small-cell- and non-small-cell lung cancer cells could be due to the pharmacological profile of its tachykinin receptor antagonist. J Physiol Pharmacol. 2015;66:421-6 pubmed
  19. Skogh A, Lesniak A, Gaugaz F, Svensson R, Lindeberg G, Fransson R, et al. Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration. Eur J Pharm Sci. 2017;109:533-540 pubmed publisher
  20. Sekizawa S, Joad J, Pinkerton K, Bonham A. Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure. Br J Pharmacol. 2011;163:782-91 pubmed publisher
    ..Our findings reveal a novel NK(1) receptor function in the primate brainstem and support the hypothesis that chronic exposure to SHS in children causes tachykinin-related neuroplastic changes in the CNS. ..
  21. Burmeister A, Johnson M, Chauhan V, Moerdyk Schauwecker M, Young A, Cooley I, et al. Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P. J Neuroinflammation. 2017;14:245 pubmed publisher
  22. Grobman M, Krumme S, Outi H, Dodam J, Reinero C. Acute neurokinin-1 receptor antagonism fails to dampen airflow limitation or airway eosinophilia in an experimental model of feline asthma. J Feline Med Surg. 2016;18:176-81 pubmed publisher
    ..A single injection of maropitant given immediately post-allergen challenge was ineffective at blunting clinical signs, AHR and airway eosinophilia, and cannot be recommended as treatment for feline status asthmaticus. ..
  23. Masumoto H, Katori Y, Kawase T, Cho B, Murakami G, Shibata S, et al. False positive reactivity of a substance P-antibody in the ectodermal/epithelial plug of the nose, ear, eye and perineum of the human and mouse fetuses. Okajimas Folia Anat Jpn. 2010;87:33-40 pubmed
    ..Which substance it crossed remains unknown. ..
  24. Saidi M, Kamali S, Ruiz A, Beaudry F. Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions. Neurochem Res. 2015;40:2304-16 pubmed publisher
    ..The results obtained revealed that PC1 and PC2 are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 protein. ..
  25. Zhao Q, Wang W, Wang R, Cheng Y. TRPV1 and neuropeptide receptor immunoreactivity and expression in the rat lung and brainstem after lung ischemia-reperfusion injury. J Surg Res. 2016;203:183-92 pubmed publisher
    ..neuropeptide receptor expressions, including calcitonin receptor-like receptor (CRLR) and neurokinin 1 receptor (NK1R), after lung ischemia-reperfusion injury (LIRI) remain uncharacterized...
  26. Grobman M, Graham A, Outi H, Dodam J, Reinero C. Chronic neurokinin-1 receptor antagonism fails to ameliorate clinical signs, airway hyper-responsiveness or airway eosinophilia in an experimental model of feline asthma. J Feline Med Surg. 2016;18:273-9 pubmed publisher
    ..669) compared with placebo. Chronic administration of maropitant was ineffective at blunting clinical signs, AHR and airway eosinophilia in experimental feline asthma and thus cannot be recommended as a novel treatment for this disorder. ..
  27. Lundstrom K, Pham H, Dinh L. Interaction of Plant Extracts with Central Nervous System Receptors. Medicines (Basel). 2017;4: pubmed publisher
    ..However, additional investigations related to plant extracts and their isolated compounds, as well as their application in animal models and the conducting of clinical trials, are required. ..
  28. Matak I, Tékus V, Bölcskei K, Lackovic Z, Helyes Z. Involvement of substance P in the antinociceptive effect of botulinum toxin type A: Evidence from knockout mice. Neuroscience. 2017;358:137-145 pubmed publisher
    ..in mice lacking the gene encoding for SP/neurokinin A (tac1-/-) or SP-preferred receptor neurokinin 1 (tac1r-/-), compared to control C57Bl/6J wild type animals...
  29. Gauda E, Bamford O, Northington F. Lack of induction of substance P gene expression by hypoxia and absence of neurokinin 1-receptor mRNAs in the rat carotid body. J Auton Nerv Syst. 1998;74:100-8 pubmed
  30. Wang D, Fan S. Microfluidic Surface Plasmon Resonance Sensors: From Principles to Point-of-Care Applications. Sensors (Basel). 2016;16: pubmed publisher
    Surface plasmon resonance (SPR) is a label-free, highly-sensitive, and real-time sensing technique...
  31. Pankratenko A, Atabekova A, Lazareva E, Baksheeva V, Zhironkina O, Zernii E, et al. Plant-specific 4/1 polypeptide interacts with an endoplasmic reticulum protein related to human BAP31. Planta. 2017;245:193-205 pubmed publisher
    ..Analyses of purified proteins expressed in bacterial cells carried out in vitro with the surface plasmon resonance (SPR) spectroscopy revealed that the N...
  32. Wen Y, Hao J, Guo X, Xiao X, Wu C, Wang S, et al. SWGDT: A sliding window-based genotype dependence testing tool for genome-wide susceptibility gene scan. J Biomed Inform. 2015;57:38-41 pubmed publisher
    ..SWGDT analysis of KBD GWAS data identified a novel candidate gene TACR1 for KBD...
  33. Ketz J, Maceroli M, Shields E, Sanders R. Peroneal Tendon Instability in Intra-Articular Calcaneus Fractures: A Retrospective Comparative Study and a New Surgical Technique. J Orthop Trauma. 2016;30:e82-7 pubmed publisher
    ..Operative notes were reviewed to confirm intraoperative testing for superior peroneal retinaculum (SPR) integrity and peroneal tendon stability...
  34. Eletxigerra U, Martinez Perdiguero J, Barderas R, Pingarrón J, Campuzano S, Merino S. Surface plasmon resonance immunosensor for ErbB2 breast cancer biomarker determination in human serum and raw cancer cell lysates. Anal Chim Acta. 2016;905:156-62 pubmed publisher
    A highly sensitive surface plasmon resonance (SPR) immunosensor for the important ErbB2 breast cancer biomarker has been developed...
  35. Fantini M, Succo G, Crosetti E, Borragán Torre A, Demo R, Fussi F. Voice Quality After a Semi-Occluded Vocal Tract Exercise With a Ventilation Mask in Contemporary Commercial Singers: Acoustic Analysis and Self-Assessments. J Voice. 2017;31:336-341 pubmed publisher
    ..Significant changes after the warm-up exercise included jitter, shimmer, and singing power ratio (SPR) in the experimental group. No significant changes were recorded in the control group...
  36. Bee J, Machiesky L, Peng L, Jusino K, Dickson M, Gill J, et al. Identification of an IgG CDR sequence contributing to co-purification of the host cell protease cathepsin D. Biotechnol Prog. 2017;33:140-145 pubmed publisher
    ..Surface plasmon resonance (SPR) was used to detect binding between immobilized CHO cathepsin D and a panel of mAbs...
  37. Bright F, Vink R, Byard R, Duncan J, Krous H, Paterson D. Abnormalities in substance P neurokinin-1 receptor binding in key brainstem nuclei in sudden infant death syndrome related to prematurity and sex. PLoS ONE. 2017;12:e0184958 pubmed publisher
    ..The neuropeptide substance P (SP) and its tachykinin neurokinin-1 receptor (NK1R) have been shown to play an integral role in the modulation of homeostatic function in the medulla, including ..
  38. Vasantharaj S, Sripriya N, Shanmugavel M, Manikandan E, Gnanamani A, Senthilkumar P. Surface active gold nanoparticles biosynthesis by new approach for bionanocatalytic activity. J Photochem Photobiol B. 2018;179:119-125 pubmed publisher
    ..Enhanced surface plasmon resonance (SPR) absorbance UV visible optical spectra were detected in the range of 552, 548, 558 and 536 nm...
  39. Yu K, Creagh A, Haynes C, Kizhakkedathu J. Modulation of Multivalent Protein Binding on Surfaces by Glycopolymer Brush Chemistry. Methods Mol Biol. 2016;1367:183-93 pubmed publisher
    ..The Surface Plasmon Resonance (SPR) spectroscopy analysis identified that by varying the spatial distribution (3D organization) of carbohydrate ..
  40. Bothra S, Upadhyay Y, Kumar R, Sahoo S. Applications of vitamin B6 cofactor pyridoxal 5'-phosphate and pyridoxal 5'-phosphate crowned gold nanoparticles for optical sensing of metal ions. Spectrochim Acta A Mol Biomol Spectrosc. 2017;174:1-6 pubmed publisher
    ..the PLP was functionalized over AuNPs surface, the wine red colour of PLP-AuNPs was turned to purplish-blue and the SPR band at ~525nm was red-shifted upon addition of Al3+, Cd2+ and Pb2+ due to the ..
  41. Tamburrini A, Achilli S, Vasile F, Sattin S, Vivès C, Colombo C, et al. Facile access to pseudo-thio-1,2-dimannoside, a new glycomimetic DC-SIGN antagonist. Bioorg Med Chem. 2017;25:5142-5147 pubmed publisher
    ..Its affinity for DC-SIGN was measured by SPR and found to be comparable to the corresponding O-linked analog, offering good opportunities for further ..
  42. Khan S, Runguo W, Tahir K, Jichuan Z, Zhang L. Catalytic reduction of 4-nitrophenol and photo inhibition of Pseudomonas aeruginosa using gold nanoparticles as photocatalyst. J Photochem Photobiol B. 2017;170:181-187 pubmed publisher
    ..Strong Plasmon resonance (SPR) of AuNPs was observed at 560nm, which indicates the formation of gold nanoparticles...
  43. Sun R, Zhang L, Zhang Z, Chen G, Jiang F. Realizing high-rate sulfur reduction under sulfate-rich conditions in a biological sulfide production system to treat metal-laden wastewater deficient in organic matter. Water Res. 2018;131:239-245 pubmed publisher
    ..In the 169-day trial, an average sulfide production rate (SPR) as high as 47 ± 9 mg S/L-h was achieved in the absence of sulfate, and the average SPR under sulfate-rich ..
  44. Zhang R, Eckert T, Lütteke T, Hanstein S, Scheidig A, Bonvin A, et al. Structure-Function Relationships of Antimicrobial Peptides and Proteins with Respect to Contact Molecules on Pathogen Surfaces. Curr Top Med Chem. 2016;16:89-98 pubmed
    ..in which various biophysical techniques such as NMR (Nuclear Magnetic Resonance), AFM (Atomic Force Microscopy), SPR (Surface Plasmon Resonance) and X-ray crystallography can be combined with biochemical and cell-biological methods ..
  45. Bignami F, Rama P, Ferrari G. Substance P and its Inhibition in Ocular Inflammation. Curr Drug Targets. 2016;17:1265-74 pubmed
    ..In addition, it will review the therapeutic effects of SP blockade to control ocular inflammation (i) in animal models and (ii) in highly prevalent human diseases. ..
  46. Miyazaki C, Pereira T, Mascagni D, de Moraes M, Ferreira M. Monoamine oxidase B layer-by-layer film fabrication and characterization toward dopamine detection. Mater Sci Eng C Mater Biol Appl. 2016;58:310-5 pubmed publisher
    ..The LbL film growth was monitored by surface plasmon resonance (SPR) by gold resonance angle shift analysis after each bilayer deposition...
  47. Höldrich M, Sievers Engler A, Lämmerhofer M. Gold nanoparticle-conjugated pepsin for efficient solution-like heterogeneous biocatalysis in analytical sample preparation protocols. Anal Bioanal Chem. 2016;408:5415-27 pubmed publisher
    ..nanoparticles were further characterized by Vis spectroscopy in terms of the surface plasmon resonance (SPR) band, by dynamic light scattering (DLS) with regard to hydrodynamic diameters, and in view of their ? potentials ..
  48. Piriya V S A, Joseph P, Daniel S C G K, Lakshmanan S, Kinoshita T, Muthusamy S. Colorimetric sensors for rapid detection of various analytes. Mater Sci Eng C Mater Biol Appl. 2017;78:1231-1245 pubmed publisher
    ..The visible sensing mechanism based on Surface Plasmon Resonance (SPR) using metal nanoparticles like Au, Ag, thin film interference using SiO2 and colorimetric array-based ..
  49. Shellaiah M, Simon T, Venkatesan P, Sun K, Ko F, Wu S. Nanodiamonds conjugated to gold nanoparticles for colorimetric detection of clenbuterol and chromium(III) in urine. Mikrochim Acta. 2017;185:74 pubmed publisher
    ..by monitoring the color change from wine red to purple blue, or by colorimetric measurement of the so-called SPR peaks at 651 and 710 nm. The color changes are due to aggregation, and this is confirmed by TEM and DLS data...
  50. Dang Z, Maselli D, Spinetti G, Sangalli E, Carnelli F, Rosa F, et al. Sensory neuropathy hampers nociception-mediated bone marrow stem cell release in mice and patients with diabetes. Diabetologia. 2015;58:2653-62 pubmed publisher
    ..BM and circulating HSPCs expressing the neurokinin 1 receptor (NK1R), which is the main SP receptor, were measured by flow cytometry...
  51. Matsishin M, Ushenin I, Rachkov A, Solatkin A. SPR Detection and Discrimination of the Oligonucleotides Related to the Normal and the Hybrid bcr-abl Genes by Two Stringency Control Strategies. Nanoscale Res Lett. 2016;11:19 pubmed publisher
    In this study, we applied two stringency control strategies for surface plasmon resonance (SPR) detection of DNA hybridization and discrimination of completely and partially complementary 24-mer sequences...
  52. Lin Y, Kazlova V, Ramakrishnan S, Murray M, Fast D, Chandra A, et al. Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study. Phytomedicine. 2016;23:18-26 pubmed publisher
    ..a number of genes involved in reduction of bone resorption including cathepsin G (CTSG) and tachykinin receptor 1 (TACR1)...
  53. Saragas N, Ferrao P, Mayet Z, Eshraghi H. Peroneal tendon dislocation/subluxation - Case series and review of the literature. Foot Ankle Surg. 2016;22:125-30 pubmed publisher
    ..The procedures varied from pure repair of the superior peroneal retinaculum (SPR), reattachment of the SPR, groove-deepening or a combination of the above...
  54. Wu G, Yeung S, Chen F. Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Dexamethasone Sodium Phosphate. Int J Pharm Compd. 2017;21:66-75 pubmed
    ..No loss of potency of any admixed component occurred in the samples stored at the temperature ranges studied. ..
  55. Chen L, Cao Y, Zhang H, Lv D, Zhao Y, Liu Y, et al. Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure. J Ethnopharmacol. 2018;219:359-368 pubmed publisher
    ..The affinity between proteins and ingredients was determined using surface plasmon resonance (SPR) assays...
  56. Wickham R. Evolving treatment paradigms for chemotherapy-induced nausea and vomiting. Cancer Control. 2012;19:3-9 pubmed
    ..The cost of using older, less expensive antiemetics may be outweighed by the expenditures to rescue patients after suboptimal prophylaxis, as well as the indirect costs of missed work and lost productivity. ..
  57. Lee T, Hirst D, Aguilar M. New insights into the molecular mechanisms of biomembrane structural changes and interactions by optical biosensor technology. Biochim Biophys Acta. 2015;1848:1868-85 pubmed publisher
    ..One of the most commonly used optical biosensor technologies is surface plasmon resonance (SPR) and there have been an increasing number of studies reporting the use of this technique for investigating ..
  58. Becherer T, Heinen S, Wei Q, Haag R, Weinhart M. In-depth analysis of switchable glycerol based polymeric coatings for cell sheet engineering. Acta Biomater. 2015;25:43-55 pubmed publisher
    ..Protein adsorption experiments on copolymer coated planar surfaces with surface plasmon resonance (SPR) spectroscopy reveal the ability of the tested thermoresponsive coatings to be switched between highly protein ..
  59. Goldfinch R, Allerton R, Khanduri S, Pettit L. The impact of the introduction of a palliative Macmillan consultant radiographer at one UK cancer centre. Br J Radiol. 2016;89:20160286 pubmed publisher
    ..Continued audit of the role is required to ensure that it complements SpR training...
  60. Nazmul Islam M, Yadav S, Hakimul Haque M, Munaz A, Islam F, Al Hossain M, et al. Optical biosensing strategies for DNA methylation analysis. Biosens Bioelectron. 2017;92:668-678 pubmed publisher
    ..been developed for analyzing DNA methylation using fluorescence, Raman spectroscopy, surface plasmon resonance (SPR), electrochemiluminescence and colorimetric readouts...
  61. Zhang Z, Zheng W, Xie H, Chai R, Wang J, Zhang H, et al. Up-regulated expression of substance P in CD8+ T cells and NK1R on monocytes of atopic dermatitis. J Transl Med. 2017;15:93 pubmed publisher
    ..However, little is known about the expression of substance P (SP) and its receptor NK1R in blood leukocytes of patients with AD...
  62. Commerford T. How many geriatricians should, at minimum, be staffing health regions in Australia?. Australas J Ageing. 2018;37:17-22 pubmed publisher
    ..There has never been a yardstick SPR, which 'defines' a satisfactory level of geriatrician manpower in any particular Australian hospital catchment...
  63. Wang H, Yang K, Hsu S, Huang M. Photothermal effects from Au-Cu2O core-shell nanocubes, octahedra, and nanobars with broad near-infrared absorption tunability. Nanoscale. 2016;8:965-72 pubmed publisher
    ..nanocrystals have become useful by illuminating Au-Cu2O nanocubes and octahedra having a surface plasmon resonance (SPR) absorption band in the near-infrared (NIR) region from octahedral Au cores with 808 nm light for heat generation...
  64. Damborský P, Švitel J, Katrlík J. Optical biosensors. Essays Biochem. 2016;60:91-100 pubmed publisher
    ..The main focus is placed on the most widely used optical biosensors which are surface plasmon resonance (SPR)-based biosensors including SPR imaging and localized SPR...
  65. Hao K, He Y, Lu H, Pu S, Zhang Y, Dong H, et al. High-sensitive surface plasmon resonance microRNA biosensor based on streptavidin functionalized gold nanorods-assisted signal amplification. Anal Chim Acta. 2017;954:114-120 pubmed publisher
    ..probe and streptavidin functionalized gold nanorods (Stre-GNRs) as tag for the enhanced surface plasmon resonance (SPR) signal...
  66. Liu F, Zhang X, Ling P, Liao J, Zhao M, Mei L, et al. Immunomodulatory effects of xanthan gum in LPS-stimulated RAW 264.7 macrophages. Carbohydr Polym. 2017;169:65-74 pubmed publisher
    ..We also analyzed the binding affinity of XG to Toll-like receptor 4 (TLR4) with surface plasmon resonance (SPR) analysis and observed that XG decreased NO, IL-6 and TNF-? secretion into the culture medium and iNOS and COX-2 ..
  67. Berger M, Von Schweinitz D. Therapeutic Innovations for Targeting Childhood Neuroblastoma: Implications of the Neurokinin-1 Receptor System. Anticancer Res. 2017;37:5911-5918 pubmed
    ..To this rep?rtoir?, the neurokinin-1 receptor (NK1R) system was recently added...
  68. Breault Turcot J, Masson J. Microdialysis SPR: diffusion-gated sensing in blood. Chem Sci. 2015;6:4247-4254 pubmed publisher
    ..To solve this problem, a dialysis chamber was introduced to a surface plasmon resonance (SPR) biosensor to create a diffusion gate for large molecules...
  69. Mustafa G, Hou J, Tsuda S, Nelson R, Sinharoy A, Wilkie Z, et al. Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI). Neuropharmacology. 2016;107:27-39 pubmed publisher
    ..IHC) studies revealed significant alterations in the expression of the serotonin (5-HT), neurokinin 1 receptor (NK1R), norepinephrine (NE), and gamma-aminobutyric acid (GABA) in the caudal trigeminal nucleus, thalamic VPL/VPM ..
  70. Wei X, Shao C, Li X, Lu N, Wang K, Zhang Z, et al. Facile in situ synthesis of plasmonic nanoparticles-decorated g-C3N4/TiO2 heterojunction nanofibers and comparison study of their photosynergistic effects for efficient photocatalytic H2 evolution. Nanoscale. 2016;8:11034-43 pubmed publisher
    ..photoactivities are attributed to the strong photosynergistic effect between the surface plasmon resonance (SPR) and the heterojunction interface sensitization, which results in the improvement of charge-carrier generation and ..
  71. David S, Polonschii C, Gheorghiu M, Bratu D, Gheorghiu E. Biosensing Based on Magneto-Optical Surface Plasmon Resonance. Methods Mol Biol. 2017;1571:73-88 pubmed publisher
    ..new approach presents improved plasmonic and magnetic properties, yet a structural stability similar to standard Au-SPR chips, allowing for bioaffinity assays in saline solutions...
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    ..applicability of three different categories of nanoplasmonic sensing techniques, namely surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR) and surface-enhanced Raman scattering (SERS), for the detection of ..
  73. Bornhop D, Kammer M, Kussrow A, Flowers R, Meiler J. Origin and prediction of free-solution interaction studies performed label-free. Proc Natl Acad Sci U S A. 2016;113:E1595-604 pubmed publisher
    ..In particular, label-free methods have flourished, such as NMR, mass spectrometry (MS), surface plasmon resonance (SPR), biolayer interferometry (BLI), and backscattering interferometry (BSI), which can facilitate assays without ..
  74. Sajfutdinow M, Uhlig K, Prager A, Schneider C, Abel B, Smith D. Nanoscale patterning of self-assembled monolayer (SAM)-functionalised substrates with single molecule contact printing. Nanoscale. 2017;9:15098-15106 pubmed publisher
    ..by atomic force microscopy (AFM), contact angle goniometry, cyclic voltammetry and surface plasmon resonance (SPR) spectroscopy...
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    ..Actions of the SP/NK-1R complex may contribute to the immune disorder underlying OLP and trigger stimuli to induce cell proliferation. These results indicate that this complex might play a role in the malignant transformation of OLP. ..
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    ..The observed pattern of NK1 receptor distribution in the brain might have functional significance for brain-related disorders showing age- and sex-related differences in prevalence. ..
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    A versatile and sensitive surface plasmon resonance (SPR) biosensor based on two layers of graphene oxide-gold nanoparticles (GO-AuNPs) composites was designed for the detection of microRNA (miRNA) and small molecule adenosine...
  78. Saleem S, Ahmed B, Khan M, Al Shaeri M, Musarrat J. Inhibition of growth and biofilm formation of clinical bacterial isolates by NiO nanoparticles synthesized from Eucalyptus globulus plants. Microb Pathog. 2017;111:375-387 pubmed publisher
    ..The XRD analysis revealed the average size of NiO-NPs as 19 nm. The UV-Vis spectroscopic data showed a strong SPR of NiO-NPs with a characteristic spectral peak at 396 nm...
  79. Zada A, Qu Y, Ali S, Sun N, Lu H, Yan R, et al. Improved visible-light activities for degrading pollutants on TiO2/g-C3N4 nanocomposites by decorating SPR Au nanoparticles and 2,4-dichlorophenol decomposition path. J Hazard Mater. 2018;342:715-723 pubmed publisher
    ..nanocomposites are attributed to the extended visible-light response due to the surface plasmonic resonance (SPR) of decorated Au and its catalytic function, and to the enhanced charge separation by transferring electrons from ..
  80. Smith R, Chua R, Carnachan S, Tan C, Sims I, Hinkley S, et al. Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation. Tissue Eng Part A. 2017;: pubmed publisher
    ..no significant effect on binding affinity toward BMP2 was observed, based on competitive surface plasmon resonance (SPR) and differential scanning fluorimetry (DSF) assays...
  81. Michna A. Macroion adsorption-electrokinetic and optical methods. Adv Colloid Interface Sci. 2017;250:95-131 pubmed publisher
    ..potential/current measurements and optical methods, such as reflectometry, ellipsometry, surface plasmon resonance (SPR), optical waveguide lightmode spectroscopy (OWLS), colloid enhancement, and fluorescence technique, for mono- and ..
  82. Rai G, Brimacombe K, Mott B, Urban D, Hu X, Yang S, et al. Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem. 2017;60:9184-9204 pubmed publisher
    ..was demonstrated using the cellular thermal shift assay (CETSA), and drug-target residence time was determined via SPR. Analysis of these data suggests that drug-target residence time (off-rate) may be an important attribute to ..
  83. Dab C, Awada C, Merlen A, Ruediger A. Near-field chemical mapping of gold nanostructures using a functionalized scanning probe. Phys Chem Chem Phys. 2017;19:31063-31071 pubmed publisher
    We report on photochemical and photophysical properties produced by Surface Plasmon Resonance (SPR) on metallic nanograins by means of high resolution Functionalized Tip-Enhanced Raman Spectroscopy (F-TERS)...
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    ..These studies demonstrate that both the extracellular and transmembrane domains of the neurokinin-1 receptor are involved in the binding of substance P and related peptides. ..
  85. Munoz M, Berger M, Rosso M, González Ortega A, Carranza A, Coveñas R. Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts. Int J Oncol. 2014;44:137-46 pubmed publisher
    ..Aprepitant is a selective high?affinity antagonist of the human neurokinin?1 (NK?1) receptor (NK1R) with robust antitumor activity...
  86. Nakashima K, Murakami H, Yokoyama K, Omori S, Wakuda K, Ono A, et al. A Phase II study of palonosetron, aprepitant, dexamethasone and olanzapine for the prevention of cisplatin-based chemotherapy-induced nausea and vomiting in patients with thoracic malignancy. Jpn J Clin Oncol. 2017;47:840-843 pubmed publisher
    ..However, standard antiemetic therapy is not completely effective in all patients...
  87. Ginting R, Kaur S, Lim D, Kim J, Lee J, Lee S, et al. Plasmonic Effect of Gold Nanostars in Highly Efficient Organic and Perovskite Solar Cells. ACS Appl Mater Interfaces. 2017;9:36111-36118 pubmed publisher
    ..in the improved optical absorption, where the improvement in OSCs was attributed to surface plasmon resonance (SPR) and in PSCs was attributed to both SPR and the backscattering effect...
  88. Kim S, Park J, Wark A, Jhung S, Lee H. Tandem Femto- and Nanomolar Analysis of Two Protein Biomarkers in Plasma on a Single Mixed Antibody Monolayer Surface Using Surface Plasmon Resonance. Anal Chem. 2017;89:12562-12568 pubmed publisher
    ..continues to be difficult for surface-based bioaffinity detection platforms such as surface plasmon resonance (SPR)...
  89. Yu K, Yau Y, Sinha A, Tan T, Kickhoefer V, Rome L, et al. Modulation of the Vault Protein-Protein Interaction for Tuning of Molecular Release. Sci Rep. 2017;7:14816 pubmed publisher
    ..The apparent affinity constants determined using surface plasmon resonance (SPR) biosensor technology are 262?±?4?nM for iMVP/INT, 1800?±?160?nM for iMVP/INT?C15 at pH 7.4...
  90. Guo C, Su F, Song Y, Hu B, Wang M, He L, et al. Aptamer-Templated Silver Nanoclusters Embedded in Zirconium Metal-Organic Framework for Bifunctional Electrochemical and SPR Aptasensors toward Carcinoembryonic Antigen. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..capacity of trace CEA, further concurrently being exploited as scaffold for surface plasmon resonance spectroscopy (SPR) and electrochemical biosensors...
  91. Kim J, Zeng Z, Xiao L, Schultz Z. Elucidating Protein- Ligand Recognition with Combined Surface Plasmon Resonance and Surface Enhanced Raman Spectroscopy. Anal Chem. 2017;: pubmed publisher
    ..Surface plasmon resonance (SPR) spectroscopy is an advanced tool to measure the binding events, yet the ability to distinguish between specific ..
  92. Deng Y, Tang L, Feng C, Zeng G, Wang J, Zhou Y, et al. Construction of plasmonic Ag modified phosphorous-doped ultrathin g-C3N4 nanosheets/BiVO4 photocatalyst with enhanced visible-near-infrared response ability for ciprofloxacin degradation. J Hazard Mater. 2018;344:758-769 pubmed publisher
    ..Considering the SPR effect of metallic Ag and the established local electric field around the interfaces, a dual Z-scheme electrons ..