TACI

Summary

Gene Symbol: TACI
Description: TNF receptor superfamily member 13B
Alias: CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B, tumor necrosis factor receptor superfamily member 13B, transmembrane activator and CAML interactor, tumor necrosis factor receptor 13B
Species: human
Products:     TACI

Top Publications

  1. Salzer U, Chapel H, Webster A, Pan Hammarstrom Q, Schmitt Graeff A, Schlesier M, et al. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet. 2005;37:820-8 pubmed
    The functional interaction of BAFF and APRIL with TNF receptor superfamily members BAFFR, TACI and BCMA is crucial for development and maintenance of humoral immunity in mice and humans...
  2. Salzer U, Birmelin J, Bacchelli C, Witte T, Buchegger Podbielski U, Buckridge S, et al. Sequence analysis of TNFRSF13b, encoding TACI, in patients with systemic lupus erythematosus. J Clin Immunol. 2007;27:372-7 pubmed
    ..APRIL), and their receptors BAFF receptor (BAFFR), B cell maturation antigen (BCMA), and transmembrane activator and CAML interactor (TACI) are involved in the regulation of B cell homeostasis and differentiation...
  3. Poodt A, Driessen G, de Klein A, van Dongen J, van der Burg M, de Vries E. TACI mutations and disease susceptibility in patients with common variable immunodeficiency. Clin Exp Immunol. 2009;156:35-9 pubmed publisher
    The most prevalent primary immunodeficiency is common variable immunodeficiency (CVID). Mutations have been described in four genes, ICOS, CD19, BAFF-R and TNFRSF13B (encoding TACI), together associated with 10-15% of CVID cases...
  4. Xu L, Shu H. TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production. J Immunol. 2002;169:6883-9 pubmed
    ..TALL-1 has three receptors, including BCMA, TACI, and BAFF-R, which are mostly expressed by B lymphocytes...
  5. Bossen C, Schneider P. BAFF, APRIL and their receptors: structure, function and signaling. Semin Immunol. 2006;18:263-75 pubmed
    ..BAFF-R has a strong selectivity for BAFF; BCMA has a higher affinity for APRIL than for BAFF, while TACI binds both ligands equally well...
  6. Xia X, Treanor J, Senaldi G, Khare S, Boone T, Kelley M, et al. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. J Exp Med. 2000;192:137-43 pubmed
    ..receptor (TNFR) homologue transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). Murine TACI was subsequently isolated from the mouse B lymphoma A20 cells...
  7. von Bülow G, Bram R. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science. 1997;278:138-41 pubmed
    ..Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific ..
  8. Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol. 2000;1:252-6 pubmed
    ..APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-I (also called BLyS or BAFF) for receptor ..
  9. Castigli E, Wilson S, Garibyan L, Rachid R, Bonilla F, Schneider L, et al. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet. 2005;37:829-34 pubmed
    The tumor necrosis factor receptor family member TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor) mediates isotype switching in B cells...

More Information

Publications62

  1. Castigli E, Wilson S, Garibyan L, Rachid R, Bonilla F, Schneider L, et al. Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency. Nat Genet. 2007;39:430-1 pubmed
  2. Speletas M, Mamara A, Papadopoulou Alataki E, Iordanakis G, Liadaki K, Bardaka F, et al. TNFRSF13B/TACI alterations in Greek patients with antibody deficiencies. J Clin Immunol. 2011;31:550-9 pubmed publisher
    TNFRSF13B/TACI defects have recently been associated with common variable immunodeficiency (CVID) pathogenesis...
  3. Mohammadi J, Liu C, Aghamohammadi A, Bergbreiter A, Du L, Lu J, et al. Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency. J Clin Immunol. 2009;29:777-85 pubmed publisher
    ..Mutations in the gene encoding TACI (Transmembrane Activator and CAML Interactor, TNFRSF13B) were previously found to be associated with CVID...
  4. Moreaux J, Sprynski A, Dillon S, Mahtouk K, Jourdan M, Ythier A, et al. APRIL and TACI interact with syndecan-1 on the surface of multiple myeloma cells to form an essential survival loop. Eur J Haematol. 2009;83:119-29 pubmed publisher
    ..BLyS and APRIL share two receptors - transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B-cell maturation antigen (BCMA) - and BLyS binds to a third receptor, BAFF-R...
  5. Chiu A, Xu W, He B, Dillon S, Gross J, Sievers E, et al. Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood. 2007;109:729-39 pubmed
    ..Myeloid cells activate B cells by producing BAFF and APRIL, which engage TACI, BCMA, and BAFF-R receptors on the B cells. Here, we studied the role of BAFF and APRIL in HL...
  6. Marsters S, Yan M, Pitti R, Haas P, Dixit V, Ashkenazi A. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr Biol. 2000;10:785-8 pubmed
    ..BLyS interacts with the TNF receptor (TNFR) homologue TACI (transmembrane activator and CAML-interactor) [5], and treatment of mice with a TACI-Fc fusion protein abolishes ..
  7. Moreaux J, Cremer F, Reme T, Raab M, Mahtouk K, Kaukel P, et al. The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature. Blood. 2005;106:1021-30 pubmed
    ..In addition, osteoclasts produce very high levels of APRIL, unlike BM stromal cells. Myeloma cells (MMCs) express TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), the receptor of BAFF/APRIL, at ..
  8. Salzer U, Jennings S, Grimbacher B. To switch or not to switch--the opposing roles of TACI in terminal B cell differentiation. Eur J Immunol. 2007;37:17-20 pubmed
    The TNF superfamily ligands BAFF and APRIL and their three receptors BAFFR, BCMA, and TACI comprise a network that is critically involved in the development and function of humoral immunity...
  9. Zhang L, Radigan L, Salzer U, Behrens T, Grimbacher B, Diaz G, et al. Transmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immunodeficiency: clinical and immunologic outcomes in heterozygotes. J Allergy Clin Immunol. 2007;120:1178-85 pubmed
    Mutations in the gene coding for transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) have been identified in common variable immunodeficiency (CVID)...
  10. Novak A, Darce J, Arendt B, Harder B, Henderson K, Kindsvogel W, et al. Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood. 2004;103:689-94 pubmed
    ..MM cells studied expressed one or more of 3 known receptors (B-cell maturation antigen [BCMA], transmembrane activator and CAML interactor [TACI], and B-cell activating factor receptor [BAFF-R]) for BLyS; however, the pattern of ..
  11. Maia S, Pelletier M, Ding J, Hsu Y, Sallan S, Rao S, et al. Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival. PLoS ONE. 2011;6:e20787 pubmed publisher
    ..observed that primary leukemia B-cell precursors aberrantly express receptors of the BAFF-system, BAFF-R, BCMA, and TACI. These receptors are functional as their ligation triggers activation of NF-?B, MAPK/JNK, and Akt signaling...
  12. Yan M, Marsters S, Grewal I, Wang H, Ashkenazi A, Dixit V. Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol. 2000;1:37-41 pubmed
    ..We identified a B cell receptor for BLyS through expression cloning as TACI, an orphan TNF receptor homologue of unknown function...
  13. Darce J, Arendt B, Wu X, Jelinek D. Regulated expression of BAFF-binding receptors during human B cell differentiation. J Immunol. 2007;179:7276-86 pubmed
    ..Furthermore, we show that TACI is expressed by MB cells and PCs, as well as a subpopulation of activated CD27(neg) B cells...
  14. Salzer U, Bacchelli C, Buckridge S, Pan Hammarstrom Q, Jennings S, Lougaris V, et al. Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes. Blood. 2009;113:1967-76 pubmed publisher
    TNFRSF13B encodes transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), a B cell- specific tumor necrosis factor (TNF) receptor superfamily member...
  15. Barroeta Seijas A, Graziani S, Cancrini C, Finocchi A, Ferrari S, Miniero R, et al. The impact of TACI mutations: from hypogammaglobulinemia in infancy to autoimmunity in adulthood. Int J Immunopathol Pharmacol. 2012;25:407-14 pubmed
    Common variable immunodeficiency (CVID) is considered the most common symptomatic antibody deficiency and, although mainly reported in adults, it may present from childhood...
  16. Pan Hammarstrom Q, Salzer U, Du L, Bjorkander J, Cunningham Rundles C, Nelson D, et al. Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency. Nat Genet. 2007;39:429-30 pubmed
  17. Wada K, Maeda K, Tajima K, Kato T, Kobata T, Yamakawa M. Expression of BAFF-R and TACI in reactive lymphoid tissues and B-cell lymphomas. Histopathology. 2009;54:221-32 pubmed publisher
    ..factor family (BAFF-R) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) have been established as binding molecules to BAFF...
  18. Sakurai D, Hase H, Kanno Y, Kojima H, Okumura K, Kobata T. TACI regulates IgA production by APRIL in collaboration with HSPG. Blood. 2007;109:2961-7 pubmed
    Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) is a member of the tumor necrosis factor (TNF) receptor family that serves as a receptor for B-cell activating factor of the TNF family (BAFF) and as a ..
  19. Gross J, Johnston J, Mudri S, Enselman R, Dillon S, Madden K, et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000;404:995-9 pubmed
    ..We have identified two TNF receptor family members, TACI and BCMA, that bind zTNF4...
  20. Moreaux J, Hose D, Jourdan M, Reme T, Hundemer M, Moos M, et al. TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines. Haematologica. 2007;92:803-11 pubmed
    BAFF and APRIL stimulate the growth of multiple myeloma (MM) cells. BAFF and APRIL share two receptors--TACI and BCMA--and BAFF binds to a third receptor, BAFF-R...
  21. Ju S, Wang Y, Ni H, Wang X, Jiang P, Kong X, et al. Correlation of expression levels of BLyS and its receptors with multiple myeloma. Clin Biochem. 2009;42:387-99 pubmed publisher
    ..52% (20/31) of these MM patients had significantly lower expression levels of TACI mRNA...
  22. Yaccoby S, Pennisi A, Li X, Dillon S, Zhan F, Barlogie B, et al. Atacicept (TACI-Ig) inhibits growth of TACI(high) primary myeloma cells in SCID-hu mice and in coculture with osteoclasts. Leukemia. 2008;22:406-13 pubmed
    ..BAFF binds to the TNF-related receptors such as B-cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI) and BAFFR, whereas APRIL binds to TACI and BCMA and to heparan sulfate proteoglycans (..
  23. Garibyan L, Lobito A, Siegel R, Call M, Wucherpfennig K, Geha R. Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest. 2007;117:1550-7 pubmed
    B cells from patients with common variable immunodeficiency (CVID) who are heterozygous for transmembrane activator and CAML interactor (TACI) mutation C104R, which abolishes ligand binding, fail to produce Igs in response to TACI ligand...
  24. López Mejías R, del Pozo N, Fernandez Arquero M, Ferreira A, Garcia Rodriguez M, de la Concha E, et al. Role of polymorphisms in the TNFRSF13B (TACI) gene in Spanish patients with immunoglobulin A deficiency. Tissue Antigens. 2009;74:42-5 pubmed publisher
    Mutations in the TNFRSF13B (TACI) gene have been associated with common variable immunodeficiency, and a role in immunoglobulin A deficiency (IgAD) has also been suggested...
  25. Zhang Y, Li J, Zhou N, Zhang Y, Wu M, Xu J, et al. The Unknown Aspect of BAFF: Inducing IL-35 Production by a CD5+CD1dhiFcγRIIbhi Regulatory B-Cell Subset in Lupus. J Invest Dermatol. 2017;137:2532-2543 pubmed publisher
    ..We further identified that BAFF-TACI interaction could induce the production of IL-35 through the classical NF-κB1 pathway...
  26. Hanitsch L, Löbel M, Mieves J, Bauer S, Babel N, Schweiger B, et al. Cellular and humoral influenza-specific immune response upon vaccination in patients with common variable immunodeficiency and unclassified antibody deficiency. Vaccine. 2016;34:2417-2423 pubmed publisher
    ..seasonal influenza with inactivated vaccine is recommended for patients with common variable immunodeficiency (CVID)...
  27. Mieves J, Wittke K, Freitag H, Volk H, Scheibenbogen C, Hanitsch L. Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID). Curr Allergy Asthma Rep. 2017;17:78 pubmed publisher
    ..Common variable immunodeficiency (CVID) is the most frequent and clinically relevant antibody deficiency disease and is by definition characterized by an ..
  28. Selenius J, Martelius T, Pikkarainen S, Siitonen S, Mattila E, Pietikäinen R, et al. Unexpectedly High Prevalence of Common Variable Immunodeficiency in Finland. Front Immunol. 2017;8:1190 pubmed publisher
    Common variable immunodeficiency (CVID) is the most common primary immunodeficiency. Prevalence varies greatly between countries and studies. Most diagnostic criteria include hypogammaglobulinemia and impaired vaccine response.
  29. Feuille E, Anooshiravani N, Sullivan K, Fuleihan R, Cunningham Rundles C. Autoimmune Cytopenias and Associated Conditions in CVID: a Report From the USIDNET Registry. J Clin Immunol. 2018;38:28-34 pubmed publisher
    Autoimmune cytopenia is frequently a presenting manifestation of common variable immune deficiency (CVID). Studies characterizing the CVID phenotype associated with autoimmune cytopenias have mostly been limited to large referral centers...
  30. Suso J, Posso Osorio I, Jimenez C, Naranjo Escobar J, Ospina F, Sanchez A, et al. Profile of BAFF and its receptors' expression in lupus nephritis is associated with pathological classes. Lupus. 2018;27:708-715 pubmed publisher
    ..for BAFF, its receptors (transmembrane activator and calcium modulator and cyclophilin ligand interaction (TACI), protein maturation of B cells (BCMA), and BAFF-receptor (BAFF-R)), and CD20 expression was performed...
  31. Desjardins M, Beland M, Dembele M, Lejtenyi D, Drolet J, Lemire M, et al. Modulation of the Interleukin-21 Pathway with Interleukin-4 Distinguishes Common Variable Immunodeficiency Patients with More Non-infectious Clinical Complications. J Clin Immunol. 2018;38:45-55 pubmed publisher
    Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and clinical manifestations such as infections, autoimmunity, and malignancy...
  32. Nguyen J, Green A, Wilson M, Derisi J, Gundling K. Neurologic Complications of Common Variable Immunodeficiency. J Clin Immunol. 2016;36:793-800 pubmed
    ..Though rare, neurologic complications have been described in a small number of case reports and case series of CVID patients...
  33. Sazzini M, Zuntini R, Farjadian S, Quinti I, Ricci G, Romeo G, et al. An evolutionary approach to the medical implications of the tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) gene. Genes Immun. 2009;10:566-78 pubmed publisher
    Coding variants in tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) have been implicated in common variable immunodeficiency (CVID), but the functional effects of such mutations in relation to the development of the ..
  34. Ramesh M, Hamm D, Simchoni N, Cunningham Rundles C. Clonal and constricted T cell repertoire in Common Variable Immune Deficiency. Clin Immunol. 2017;178:1-9 pubmed publisher
    ..to examine the structure and composition of the T cell receptor β chain in Common Variable Immune Deficiency (CVID)...
  35. Lougaris V, Gallizzi R, Vitali M, Baronio M, Salpietro A, Bergbreiter A, et al. A novel compound heterozygous TACI mutation in an autosomal recessive common variable immunodeficiency (CVID) family. Hum Immunol. 2012;73:836-9 pubmed publisher
    ..genetic causes are only known in less than 15% of patients and encompass mutations in the genes encoding for ICOS, TACI, BAFF-R, CD19, CD20, CD81 and MSH5. TACI is the most frequently mutated gene among CVID patients...
  36. Nagai M, Hirayama K, Ebihara I, Kobayashi M. Serum soluble levels of the transmembrane activator and calcium-modulator and cyclophilin-ligand interactor in MPO-ANCA-associated renal vasculitis. Clin Exp Nephrol. 2015;19:759-60 pubmed publisher
  37. Hanley P, Sutter J, Goodman N, Du Y, Sekiguchi D, Meng W, et al. Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes. Clin Immunol. 2017;183:336-343 pubmed publisher
    ..and controls, some T1D subjects exhibited reduced proportions of B cells that expressed transmembrane activator and CAML interactor (TACI) and Fas receptor (FasR)...
  38. Lucena J, Burillo Sanz S, Nunez Roldan A, Sanchez B. Incidence of the C104R TACI Mutation in Patients With Primary Antibody Deficiency. J Investig Allergol Clin Immunol. 2015;25:378-9 pubmed
  39. Tran N, Schneider P, Santiago Raber M. TACI-dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosus. Eur J Immunol. 2017;47:713-723 pubmed publisher
    ..a proliferation-inducing ligand), a member of the TNF superfamily, regulates plasma-cell survival and binds to TACI (transmembrane activator CAML interactor) and BCMA (B-cell maturation antigen)...
  40. Chinen J, Martinez Gallo M, Gu W, Cols M, Cerutti A, Radigan L, et al. Transmembrane activator and CAML interactor (TACI) haploinsufficiency results in B-cell dysfunction in patients with Smith-Magenis syndrome. J Allergy Clin Immunol. 2011;127:1579-86 pubmed publisher
    Heterozygous deleterious mutations in the gene encoding the tumor necrosis factor receptor superfamily member 13b (TNFRSF13B), or transmembrane activator and CAML interactor (TACI), have been associated with the development of common ..
  41. Jasek M, Wagner M, Sobczynski M, Wolowiec D, Kuliczkowski K, Woszczyk D, et al. Polymorphisms in genes of the BAFF/APRIL system may constitute risk factors of B-CLL--a preliminary study on a Polish population. Tissue Antigens. 2015;86:279-84 pubmed publisher
    ..20 SNPs of BAFF, APRIL, BAFF-R, transmembrane activator and calcium modulator and cyclophilin-ligand interactor (TACI), B-cell maturation antigen (BCMA) genes and the risk and outcome of B-CLL in 187 patients and 296 healthy subjects ..
  42. Guffroy A, Mourot Cottet R, Gerard L, Gies V, Lagresle C, Pouliet A, et al. Neutropenia in Patients with Common Variable Immunodeficiency: a Rare Event Associated with Severe Outcome. J Clin Immunol. 2017;37:715-726 pubmed publisher
    Common variable immunodeficiency (CVID) is characterized by infections and hypogammaglobulinemia. Neutropenia is rare during CVID. The French DEFI study enrolled patients with primary hypogammaglobulinemia...
  43. Lee J, Jabara H, Garibyan L, Rauter I, Sannikova T, Dillon S, et al. The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency. J Allergy Clin Immunol. 2010;126:1234-41.e2 pubmed publisher
    TNFRSF13B, which encodes transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), is mutated in 10% of patients with common variable immunodeficiency...
  44. Azzu V, Elias J, Duckworth A, Davies S, Brais R, Kumararatne D, et al. Liver transplantation in adults with liver disease due to common variable immunodeficiency leads to early recurrent disease and poor outcome. Liver Transpl. 2017;: pubmed publisher
    Common variable immunodeficiency (CVID) is the commonest from of primary immunodeficiency characterized by antibody deficiency, recurrent bacterial infections and autoimmunity...
  45. Mamara A, Germenis A, Kompoti M, Palassopoulou M, Mandala E, Banti A, et al. TACI expression and signaling in chronic lymphocytic leukemia. J Immunol Res. 2015;2015:478753 pubmed publisher
    b>TACI is a membrane receptor of BAFF and APRIL, contributing to the differentiation and survival of normal B cells...
  46. Inoue K, Mineharu Y, Inoue S, Yamada S, Matsuda F, Nozaki K, et al. Search on chromosome 17 centromere reveals TNFRSF13B as a susceptibility gene for intracranial aneurysm: a preliminary study. Circulation. 2006;113:2002-10 pubmed
    ..69, 95% confidence interval 0.52 to 0.92, P=0.012) compared with the major haplotype after adjustment for covariates. We propose that TNFRSF13B is one of the susceptibility genes for IA. ..
  47. Castigli E, Geha R. TACI, isotype switching, CVID and IgAD. Immunol Res. 2007;38:102-11 pubmed
    Common Variable Immunodeficiency (CVID) is the most prevalent human primary immunodeficiency requiring medical attention...
  48. Waldrep M, Zhuang Y, Schroeder H. Analysis of TACI mutations in CVID & RESPI patients who have inherited HLA B*44 or HLA*B8. BMC Med Genet. 2009;10:100 pubmed publisher
    Recent reports have suggested that Common Variable Immunodeficieny (CVID) can present as an autosomal dominant trait dependent on the inheritance of a set of uncommon mutations/alleles of TACI (transmembrane activator and calcium-..
  49. Ameratunga R, Lehnert K, Woon S, Gillis D, Bryant V, Slade C, et al. Review: Diagnosing Common Variable Immunodeficiency Disorder in the Era of Genome Sequencing. Clin Rev Allergy Immunol. 2018;54:261-268 pubmed publisher
    Common variable immunodeficiency disorders (CVID) are an enigmatic group of often heritable conditions, which may manifest for the first time in early childhood or as late as the eighth decade of life...
  50. Holm K, Syljuåsen R, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, et al. TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency. PLoS ONE. 2017;12:e0185708 pubmed publisher
    ..of normal peripheral blood B-cells, and of B-cells from patients diagnosed with Common variable immunodeficiency (CVID). The TLR9-mediated survival is enhanced by the vitamin A metabolite retinoic acid (RA)...
  51. Li K, Yu W, Cao R, Zhu Z, Zhao G. Microglia-mediated BAFF-BAFFR ligation promotes neuronal survival in brain ischemia injury. Neuroscience. 2017;363:87-96 pubmed publisher
    ..Furthermore, blocking BAFF-BAFFR ligation with TACI-Ig abrogated these therapeutic benefits...
  52. Saurabh K, Nag V, Khera D, Elhence P. Giardiasis mimicking celiac disease in a patient of common variable immunodeficiency. Trop Parasitol. 2017;7:125-127 pubmed publisher
    ..In patients of common variable immunodeficiency (CVID), who present with features of CD, coinfection, especially with G...
  53. van Schouwenburg P, Davenport E, Kienzler A, Marwah I, Wright B, Lucas M, et al. Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders. Clin Immunol. 2015;160:301-14 pubmed publisher
    ..Here, we performed whole genome sequencing (WGS) of 34 CVID patients (94% sporadic) and combined them with transcriptomic profiling (RNA-sequencing of B cells) from three ..