TACC3

Summary

Gene Symbol: TACC3
Description: transforming acidic coiled-coil containing protein 3
Alias: ERIC-1, ERIC1, transforming acidic coiled-coil-containing protein 3
Species: human
Products:     TACC3

Top Publications

  1. Gómez Baldó L, Schmidt S, Maxwell C, Bonifaci N, Gabaldón T, Vidalain P, et al. TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle. 2010;9:1143-55 pubmed
    ..Here, TACC3 interactome mapping identified TSC2 and 15 other physical interactors, including the evolutionary conserved ..
  2. Williams S, Hurst C, Knowles M. Oncogenic FGFR3 gene fusions in bladder cancer. Hum Mol Genet. 2013;22:795-803 pubmed publisher
    ..FGFR3-transforming acid coiled coil 3 (TACC3) fusions resulting from 4p16...
  3. Lappin T, Mullan R, Stewart J, Morgan N, Thompson A, Maxwell A. AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains. Leuk Lymphoma. 2002;43:1455-9 pubmed
    ..Database searches employing the human TACC1 sequence revealed other novel genes, TACC2 and TACC3, with substantial sequence homology particularly in the C-terminal regions encoding the coiled coil domains...
  4. Sadek C, Pelto Huikko M, Tujague M, Steffensen K, Wennerholm M, Gustafsson J. TACC3 expression is tightly regulated during early differentiation. Gene Expr Patterns. 2003;3:203-11 pubmed
    ..Our current studies aim to delineate the expression pattern of TACC3 protein during cellular differentiation and in a variety of normal human tissues...
  5. Yao R, Kondoh Y, Natsume Y, Yamanaka H, Inoue M, Toki H, et al. A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells. Oncogene. 2014;33:4242-52 pubmed publisher
    ..In humans, TACC3 is aberrantly expressed in a variety of human cancers, but its biological significance remains to be elucidated...
  6. Piekorz R, Hoffmeyer A, Duntsch C, McKay C, Nakajima H, Sexl V, et al. The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J. 2002;21:653-64 pubmed
    b>TACC3 is a centrosomal/mitotic spindle-associated protein that is highly expressed in a cell cycle-dependent manner in hematopoietic lineage cells...
  7. Angrisano T, Lembo F, Pero R, Natale F, Fusco A, Avvedimento V, et al. TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters. Nucleic Acids Res. 2006;34:364-72 pubmed
    ..Here we show that another unrelated protein, TACC3, displays a similar activity on methylated genes...
  8. Singh D, Chan J, Zoppoli P, Niola F, Sullivan R, Castaño A, et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science. 2012;337:1231-5 pubmed publisher
    ..receptor (FGFR) genes (FGFR1 or FGFR3) to the transforming acidic coiled-coil (TACC) coding domains of TACC1 or TACC3, respectively...
  9. Duncan C, Killela P, Payne C, Lampson B, Chen W, Liu J, et al. Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. Oncotarget. 2010;1:265-77 pubmed
    ..Furthermore, we demonstrate that TACC3, an Aurora-A kinase substrate, on 4p16...

More Information

Publications106 found, 100 shown here

  1. Booth D, Hood F, Prior I, Royle S. A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO J. 2011;30:906-19 pubmed publisher
    ..In this study, we show that clathrin at the mitotic spindle is in a transforming acidic colied-coil protein 3 (TACC3)/colonic, hepatic tumour overexpressed gene (ch-TOG)/clathrin complex...
  2. Jeng J, Lin Y, Lin C, Shih H. Cdh1 controls the stability of TACC3. Cell Cycle. 2009;8:3537-44 pubmed
    Transforming acidic coiled-coil protein 3 (TACC3) was reported to be important for regulating mitotic spindle assembly and chromosome segregation...
  3. Lin C, Hu C, Shih H. Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. J Cell Biol. 2010;189:1097-105 pubmed publisher
    ..Aurora A regulates spindle assembly in part via phosphorylating human TACC3 on S558, which triggers TACC3 relocalization to mitotic spindles and stabilizes microtubules (MTs)...
  4. Lioutas A, Vernos I. Aurora A kinase and its substrate TACC3 are required for central spindle assembly. EMBO Rep. 2013;14:829-36 pubmed publisher
    ..We also identify TACC3 as an AurA substrate essential in central spindle formation.
  5. Gangisetty O, Lauffart B, Sondarva G, Chelsea D, Still I. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. Oncogene. 2004;23:2559-63 pubmed
    ..This raises the possibility that aberrant expression of one or more TACC proteins may affect gene regulation through their interaction with components of chromatin remodeling complexes, thus contributing to tumorigenesis. ..
  6. Schmidt S, Schneider L, Essmann F, Cirstea I, Kuck F, Kletke A, et al. The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene. 2010;29:6184-92 pubmed publisher
    ..Unlike PTX, knockdown of TACC3 did not trigger a cell death response, but instead resulted in a progressive loss of the pro-apoptotic Bcl-2 ..
  7. Fu W, Tao W, Zheng P, Fu J, Bian M, Jiang Q, et al. Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. J Cell Sci. 2010;123:3645-51 pubmed publisher
    Transforming acidic coiled-coil-containing protein 3 (TACC3) has been implicated in mitotic spindle assembly, although the mechanisms involved are largely unknown...
  8. Ulisse S, Baldini E, Toller M, Delcros J, Guého A, Curcio F, et al. Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues. Endocr Relat Cancer. 2007;14:827-37 pubmed
    ..Among the Aurora-A substrates identified, transforming acidic coiled-coil (TACC3), a member of the TACC family, plays an important role in cell cycle progression and alterations of its expression ..
  9. Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff J. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. Proc Natl Acad Sci U S A. 2000;97:14352-7 pubmed
    ..at centrosomes during mitosis; TACC2 is strongly concentrated at centrosomes throughout the cell cycle; and TACC3 is strongly concentrated in a more diffuse region around centrosomes during mitosis...
  10. Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, et al. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J Biol Chem. 2007;282:29273-83 pubmed
    ..By employing gene targeting, we have recently described a nonredundant and essential role of TACC3 in regulating cell proliferation...
  11. Yim E, Tong S, Ho E, Bae J, Um S, Park J. Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells. Oncol Rep. 2009;21:549-57 pubmed
    ..b>TACC3 mRNA and protein levels decreased after paclitaxel treatment in a time- and dose-dependent manner, and the ..
  12. Parker B, Annala M, Cogdell D, Granberg K, Sun Y, Ji P, et al. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest. 2013;123:855-65 pubmed publisher
    ..We performed whole transcriptome sequencing to identify fusion genes in glioma and discovered FGFR3-TACC3 fusions in 4 of 48 glioblastoma samples from patients both of mixed European and of Asian descent, but not in any ..
  13. Ha G, Park J, Breuer E. TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways. Cancer Lett. 2013;332:63-73 pubmed publisher
    Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family, essential for mitotic spindle dynamics and centrosome integrity during mitosis...
  14. Still I, Vince P, Cowell J. The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. Genomics. 1999;58:165-70 pubmed
    ..We have now characterized the human and mouse TACC3 cDNAs, and demonstrate that this gene is upregulated in various cancer cell lines, and at Embryonic Day 15 in mice,..
  15. McKeveney P, Hodges V, Mullan R, Maxwell P, Simpson D, Thompson A, et al. Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells. Br J Haematol. 2001;112:1016-24 pubmed
    ..In addition to erythroid precursor cells, ERIC-1/TACC3 is expressed at high levels in the testes, at moderate levels in the thymus and peripheral leucocytes, and at ..
  16. Kiemeney L, Sulem P, Besenbacher S, Vermeulen S, Sigurdsson A, Thorleifsson G, et al. A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Nat Genet. 2010;42:415-9 pubmed publisher
    ..3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC...
  17. Tsai H, Chou M, Wu C, Wan M, Kuo Y, Chen J, et al. Seasonal Distribution and Genotyping of Antibiotic Resistant Strains of ListeriaInnocua Isolated from A River Basin Categorized by ERIC-PCR. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..The more commonly detected types, such as ERIC1 and ERIC12, were also more likely to be resistant to two or more antibiotics...
  18. Thakur H, Singh M, Nagel Steger L, Kremer J, Prumbaum D, Fansa E, et al. The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner. J Biol Chem. 2014;289:74-88 pubmed publisher
    The cancer-associated, centrosomal adaptor protein TACC3 (transforming acidic coiled-coil 3) and its direct effector, the microtubule polymerase chTOG (colonic and hepatic tumor overexpressed gene), play a crucial function in centrosome-..
  19. Nwagbara B, Faris A, Bearce E, Erdogan B, Ebbert P, Evans M, et al. TACC3 is a microtubule plus end-tracking protein that promotes axon elongation and also regulates microtubule plus end dynamics in multiple embryonic cell types. Mol Biol Cell. 2014;25:3350-62 pubmed publisher
    ..The centrosome-associated protein TACC3, a member of the transforming acidic coiled-coil (TACC) domain family, has been implicated in regulating several ..
  20. Javle M, Churi C, Kang H, Shroff R, Janku F, Surapaneni R, et al. HER2/neu-directed therapy for biliary tract cancer. J Hematol Oncol. 2015;8:58 pubmed publisher
    ..One patient developed HER2/neu amplification as a secondary event after FGFR-directed therapy for FGF3-TACC3 gene fusion...
  21. Lee J, Kim K, Sung H, Jeon H, Jeong B, Seo S, et al. Molecular Characterization of Urothelial Carcinoma of the Bladder and Upper Urinary Tract. Transl Oncol. 2017;11:37-42 pubmed publisher
    ..We also identified five translocations in the entire study population, including one case with FGFR3-TACC3 (Chr4) fusion...
  22. Qin A, Johnson A, Ross J, Miller V, Ali S, Schrock A, et al. Detection of Known and Novel FGFR Fusions in Non-Small Cell Lung Cancer by Comprehensive Genomic Profiling. J Thorac Oncol. 2019;14:54-62 pubmed publisher
    ..37 fibroblast growth factor receptor gene 3 (FGFR3)-transforming acidic coiled-coil containing protein 3 gene (TACC3) fusion-positive cases, two fibroblast growth factor receptor 2 (FGFR2)-shootin 1 gene (KIAA1598 [also known as ..
  23. Gulluni F, Martini M, De Santis M, Campa C, Ghigo A, Margaria J, et al. Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2? Scaffolding Function. Cancer Cell. 2017;32:444-459.e7 pubmed publisher
    ..of class II phosphoinositide 3-OH kinase ? (PI3K-C2?) acting as limiting scaffold protein organizing clathrin and TACC3 complex crosslinking K-fibers...
  24. Zhao C, He X, Li H, Zhou J, Han X, Wang D, et al. Downregulation of TACC3 inhibits tumor growth and migration in osteosarcoma cells through regulation of the NF-κB signaling pathway. Oncol Lett. 2018;15:6881-6886 pubmed publisher
    b>TACC3, a member of the transforming acidic coiled-coil protein (TACC) family, is a multifunctional protein that is involved in various biological functions, including proliferation and differentiation of tumor cells, cancer progression ..
  25. Ohoka N, Nagai K, Hattori T, Okuhira K, Shibata N, Cho N, et al. Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway. Cell Death Dis. 2014;5:e1513 pubmed publisher
    ..In this study, we designed and synthesized novel small molecules called SNIPER(TACC3)s, which target the spindle regulatory protein transforming acidic coiled-coil-3 (TACC3)...
  26. Yao R, Oyanagi J, Natsume Y, Kusama D, Kato Y, Nagayama S, et al. Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells. Oncogene. 2016;35:6109-6119 pubmed publisher
    ..This system was used to evaluate the potential of a cancer-related spindle protein, Tacc3, as a target of cancer therapy, as its disruption led to the suppression of tumor formation in an animal model of ..
  27. Burgess S, Bayliss R, Pfuhl M. Solution NMR assignment of the cryptic sixth TOG domain of mini spindles. Biomol NMR Assign. 2015;9:411-3 pubmed publisher
    ..Instead it forms part of a binding site for TACC3 family proteins...
  28. Best S, Harapas C, Kersbergen A, Rathi V, Asselin Labat M, Sutherland K. FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium. Oncogene. 2018;37:6096-6104 pubmed publisher
    ..of a genetic fusion between fibroblast growth factor receptor 3 (FGFR3) and transforming acidic coiled-coil 3 (TACC3) in non-small cell lung cancer (NSCLC), providing a novel target for FGFR inhibition...
  29. Ha G, Kim J, Breuer E, Breuer E. TACC3 is essential for EGF-mediated EMT in cervical cancer. PLoS ONE. 2013;8:e70353 pubmed publisher
    The third member of transforming acidic coiled-coil protein (TACC) family, TACC3, has been shown to be an important player in the regulation of centrosome/microtubule dynamics during mitosis and found to be deregulated in a variety of ..
  30. Petschnigg J, Kotlyar M, Blair L, Jurisica I, Stagljar I, Ketteler R. Systematic Identification of Oncogenic EGFR Interaction Partners. J Mol Biol. 2017;429:280-294 pubmed publisher
    ..Depletion of TACC3 from cells using small hairpin RNA (shRNA) knockdown or small-molecule targeting reduced mitogenic signaling in ..
  31. Bellmunt J, Lalani A, Jacobus S, Wankowicz S, Polacek L, Takeda D, et al. Everolimus and pazopanib (E/P) benefit genomically selected patients with metastatic urothelial carcinoma. Br J Cancer. 2018;119:707-712 pubmed publisher
    ..clinical benefit (one CR, two PR, one SD) had mutations in TSC1/TSC2 or mTOR and a 5th patient with PR had a FGFR3-TACC3 fusion...
  32. Nahm J, Kim H, Lee H, Cho J, Choi Y, Yoon Y, et al. Transforming acidic coiled-coil-containing protein 3 (TACC3) overexpression in hepatocellular carcinomas is associated with "stemness" and epithelial-mesenchymal transition-related marker expression and a poor prognosis. Tumour Biol. 2016;37:393-403 pubmed publisher
    ..3 locus containing the TACC3 gene, which has previously not been described in HCCs...
  33. Daly C, Castanaro C, Zhang W, Zhang Q, Wei Y, Ni M, et al. FGFR3-TACC3 fusion proteins act as naturally occurring drivers of tumor resistance by functionally substituting for EGFR/ERK signaling. Oncogene. 2017;36:471-481 pubmed publisher
    ..RNA sequencing revealed that resistant cells express FGFR3-TACC3 fusion proteins, which were validated as drivers of the resistant phenotype by several approaches, including ..
  34. Nixon F, Honnor T, Clarke N, Starling G, Beckett A, Johansen A, et al. Microtubule organization within mitotic spindles revealed by serial block face scanning electron microscopy and image analysis. J Cell Sci. 2017;130:1845-1855 pubmed publisher
    ..We use these tools to show that microtubule order in mitotic spindles is sensitive to the level of TACC3 on the spindle.
  35. Karkera J, Cardona G, Bell K, Gaffney D, Portale J, Santiago Walker A, et al. Oncogenic Characterization and Pharmacologic Sensitivity of Activating Fibroblast Growth Factor Receptor (FGFR) Genetic Alterations to the Selective FGFR Inhibitor Erdafitinib. Mol Cancer Ther. 2017;16:1717-1726 pubmed publisher
    ..In a phase I study, a heavily pretreated bladder cancer patient with an FGFR3-TACC3 translocation experienced a partial response when treated with erdafitinib...
  36. Frattini V, Pagnotta S, Tala -, Fan J, Russo M, Lee S, et al. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 2018;553:222-227 pubmed publisher
    ..We have previously described gene fusions of FGFR3-TACC3 (F3-T3) in 3% of human glioblastoma cases...
  37. Di Stefano A, Fucci A, Frattini V, Labussiere M, Mokhtari K, Zoppoli P, et al. Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma. Clin Cancer Res. 2015;21:3307-17 pubmed publisher
    ..We also analyzed expression of the FGFR3 and TACC3 components of the fusions...
  38. Mahdipour M, Leitoguinho A, Zacarias Silva R, van Tol H, Stout T, Rodrigues G, et al. TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes. PLoS ONE. 2015;10:e0132591 pubmed publisher
    ..We used bovine oocytes to study the expression and function of TACC3 during meiosis...
  39. Fielding A, Lim S, Montgomery K, Dobreva I, Dedhar S. A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Oncogene. 2011;30:521-34 pubmed publisher
    ..in a focal adhesion-independent, but centrosome-dependent, manner through the microtubule regulating proteins TACC3 and ch-TOG...
  40. Gutiérrez Caballero C, Burgess S, Bayliss R, Royle S. TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation. Biol Open. 2015;4:170-9 pubmed publisher
    The interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved...
  41. O Regan L, Sampson J, Richards M, Knebel A, Roth D, Hood F, et al. Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. J Cell Biol. 2015;209:349-58 pubmed publisher
    ..Mechanistically, Hsp72 associates with the K-fiber-stabilizing proteins, ch-TOG and TACC3, and promotes their interaction with each other and recruitment to spindle microtubules (MTs)...
  42. Chou C, Loh J, Yang M, Lin C, Hong M, Cho C, et al. AIBp regulates mitotic entry and mitotic spindle assembly by controlling activation of both Aurora-A and Plk1. Cell Cycle. 2015;14:2764-76 pubmed publisher
    ..Our data show that depletion of AIBp results in the mis-localization of TACC3 and ch-TOG, but not CEP192 and CEP215, suggesting that loss of AIBp dominantly affects the Aurora-A substrate to ..
  43. Tamura R, Yoshihara K, Saito T, Ishimura R, Martínez Ledesma J, Xin H, et al. Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions. Oncogenesis. 2018;7:4 pubmed publisher
    ..We detected 445 high confidence fusion transcripts and identified four samples that harbored FGFR3-TACC3 fusion as an attractive therapeutic target. The frequency of FGFR3-TACC3-fusion-positive cervical cancer is also 1...
  44. Rostkova E, Burgess S, Bayliss R, Pfuhl M. Solution NMR assignment of the C-terminal domain of human chTOG. Biomol NMR Assign. 2018;12:221-224 pubmed publisher
    ..It was shown that the C-terminal domain is important for the interaction with the TACC domain in TACC3 during the assembly of k-fibres in a ternary complex that also includes clathrin...
  45. Lin Z, Wang M, He S, Cai Z, Huang W. TACC3 transcriptionally upregulates E2F1 to promote cell growth and confer sensitivity to cisplatin in bladder cancer. Cell Death Dis. 2018;9:72 pubmed publisher
    Accumulating evidence has shown that transforming acidic coiled-coil 3 (TACC3) is deregulated in a broad spectrum of cancers...
  46. Wang L, Šuštić T, Leite De Oliveira R, Lieftink C, Halonen P, van de Ven M, et al. A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma. Eur Urol. 2017;71:858-862 pubmed publisher
    ..inhibitor AZD4547 using a short hairpin RNA library targeting the human kinome in the UCC cell line RT112 (FGFR3-TACC3 translocation)...
  47. Erdogan B, Cammarata G, Lee E, Pratt B, Francl A, Rutherford E, et al. The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development. Neural Dev. 2017;12:3 pubmed publisher
    ..b>TACC3 is a + TIP that we have previously implicated in regulating MT dynamics within axons...
  48. Lucaj C, Evans M, Nwagbara B, Ebbert P, Baker C, Volk J, et al. Xenopus TACC1 is a microtubule plus-end tracking protein that can regulate microtubule dynamics during embryonic development. Cytoskeleton (Hoboken). 2015;72:225-34 pubmed publisher
    ..We recently demonstrated that the transforming acidic coiled-coil (TACC) domain family member, TACC3, can function as a +TIP to regulate microtubule dynamics in Xenopus laevis embryonic cells...
  49. Nozad S, Sheehan C, Gay L, Elvin J, Vergilio J, Suh J, et al. Comprehensive genomic profiling of malignant phyllodes tumors of the breast. Breast Cancer Res Treat. 2017;162:597-602 pubmed publisher
    ..8%), MED12 (45.8%), CDKN2A/B (33.3%), and MLL2 (33.3%). Targetable kinase fusions including KIAA1549-BRAF or FGFR3-TACC3 were identified in 2/24 (8.3%) tumors...
  50. Dhami J, Hirshfield K, Ganesan S, Hellmann M, Rojas V, Amorosa J, et al. Comprehensive Genomic Profiling Aids in Treatment of a Metastatic Endometrial Cancer. Cold Spring Harb Mol Case Stud. 2018;: pubmed publisher
    FGFR-TACC fusions, including FGFR3-TACC3, have been identified as potential oncogenic drivers and actionable alterations in a number of different cancer types...
  51. Jiang F, Kuang B, Que Y, Lin Z, Yuan L, Xiao W, et al. The clinical significance of transforming acidic coiled-coil protein 3 expression in non-small cell lung cancer. Oncol Rep. 2016;35:436-46 pubmed publisher
    The relationship between TACC3, a member of the transforming acidic coiled-coil proteins (TACCs) family, and lung carcinoma remains unclear...
  52. Wang Z, Zhang C, Sun L, Liang J, Liu X, Li G, et al. FGFR3, as a receptor tyrosine kinase, is associated with differentiated biological functions and improved survival of glioma patients. Oncotarget. 2016;7:84587-84593 pubmed publisher
    Activation of receptor tyrosine kinases is common in Malignancies. FGFR3 fusion with TACC3 has been reported to have transforming effects in primary glioblastoma and display oncogenic activity in vitro and in vivo...
  53. Ou S, Horn L, Cruz M, Vafai D, Lovly C, Spradlin A, et al. Emergence of FGFR3-TACC3 fusions as a potential by-pass resistance mechanism to EGFR tyrosine kinase inhibitors in EGFR mutated NSCLC patients. Lung Cancer. 2017;111:61-64 pubmed publisher
    ..reports have demonstrated that actionable receptor tyrosine kinase fusions such as EML4-ALK, CCDC6-RET, and FGFR3-TACC3 can potentially confer resistance to EGFR TKIs...
  54. Campo L, Breuer E. Inhibition of TACC3 by a small molecule inhibitor in breast cancer. Biochem Biophys Res Commun. 2018;498:1085-1092 pubmed publisher
    Studies have shown that transforming acidic coiled-coil protein 3 (TACC3), a key component of centrosome-microtubule dynamic networks, is significantly associated with various types of human cancer...
  55. Nixon F, Gutiérrez Caballero C, Hood F, Booth D, Prior I, Royle S. The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle. elife. 2015;4: pubmed publisher
    ..Molecular manipulation of the mesh by overexpression of TACC3 causes disorganization of the K-fiber MTs...
  56. Burgess S, Peset I, Joseph N, Cavazza T, Vernos I, Pfuhl M, et al. Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly. PLoS Genet. 2015;11:e1005345 pubmed publisher
    The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation...
  57. Men X, Shibata Y, Takeshita T, Yamashita Y. Identification of Anion Channels Responsible for Fluoride Resistance in Oral Streptococci. PLoS ONE. 2016;11:e0165900 pubmed publisher
    ..BLAST studies showed that two types of eriCs (eriC1 and eriC2) and two types of crcBs (crcB1 and crcB2) are present across 18 oral streptococci, which were identified ..
  58. Burgess S, Mukherjee M, Sabir S, Joseph N, Gutiérrez Caballero C, Richards M, et al. Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix. EMBO J. 2018;37: pubmed publisher
    Aurora-A regulates the recruitment of TACC3 to the mitotic spindle through a phospho-dependent interaction with clathrin heavy chain (CHC)...
  59. Shaver T, Lehmann B, Beeler J, Li C, Li Z, Jin H, et al. Diverse, Biologically Relevant, and Targetable Gene Rearrangements in Triple-Negative Breast Cancer and Other Malignancies. Cancer Res. 2016;76:4850-60 pubmed publisher
    ..tyrosine kinase (MERTK) and discovered a clinical occurrence and cell line model of the targetable FGFR3-TACC3 fusion in TNBC...
  60. Rutherford E, Carandang L, Ebbert P, Mills A, Bowers J, Lowery L. Xenopus TACC2 is a microtubule plus end-tracking protein that can promote microtubule polymerization during embryonic development. Mol Biol Cell. 2016;27:3013-3020 pubmed
    ..We previously showed that TACC1 and TACC3, members of the transforming acidic coiled-coil protein family, can act as +TIPs to regulate MT dynamics in ..
  61. Prashar Y, Weissman S. Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs. Proc Natl Acad Sci U S A. 1996;93:659-63 pubmed
    ..These and other results suggest that this approach is suitable for the systematic, expeditious, and nearly exhaustive elucidation of subtle changes in the patterns of gene expression in cells with altered physiologic states. ..
  62. Fu W, Chen H, Wang G, Luo J, Deng Z, Xin G, et al. Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly. Proc Natl Acad Sci U S A. 2013;110:15295-300 pubmed publisher
    ..Here we show that transforming acidic coiled-coil-containing protein 3 (TACC3) is essential for kinetochore capture and proper K-fiber formation in HeLa cells...
  63. Ha G, Kim J, Petersson A, Oh S, Denning M, Patel T, et al. TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition. Oncogene. 2015;34:1667-78 pubmed publisher
    Deregulation of the transforming acidic coiled-coil protein 3 (TACC3), an important factor in the centrosome-microtubule system, has been linked to a variety of human cancer types...
  64. Du Y, Liu L, Wang C, Kuang B, Yan S, Zhou A, et al. TACC3 promotes colorectal cancer tumourigenesis and correlates with poor prognosis. Oncotarget. 2016;7:41885-41897 pubmed publisher
    ..Transforming acidic coiled-coil protein-3 (TACC3), a frequently aberrantly expressed oncogene, is an important biomarker in various human cancers...
  65. He J, Yao W, Wang J, Schemmer P, Yang Y, Liu Y, et al. TACC3 overexpression in cholangiocarcinoma correlates with poor prognosis and is a potential anti-cancer molecular drug target for HDAC inhibitors. Oncotarget. 2016;7:75441-75456 pubmed publisher
    ..Microarray analysis revealed that TACC3 mRNA was down-regulated in CCA cells treated with TSA...
  66. Ohoka N, Nagai K, Shibata N, Hattori T, Nara H, Cho N, et al. SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. Cancer Sci. 2017;108:1032-1041 pubmed publisher
    ..molecule SNIPER (Specific and Nongenetic IAP-dependent Protein ERaser) against transforming acidic coiled-coil-3 (TACC3), SNIPER(TACC3), that induces proteasomal degradation of TACC3 protein...
  67. Li Q, Ye L, Guo W, Wang M, Huang S, Peng X. Overexpression of TACC3 is correlated with tumor aggressiveness and poor prognosis in prostate cancer. Biochem Biophys Res Commun. 2017;486:872-878 pubmed publisher
    Transforming acidic coiled-coil (TACC3), a member of the TACC family, has been shown to be deregulated in various cancers and involved in tumor progression...
  68. Meng X, Shi M, Chen J, Liao Y, Hu B, Hireche A. Association between the TACC3 rs798766 Polymorphism and Risk of Urinary Bladder Cancer: A Synthesis Based on Current Evidence. Dis Markers. 2017;2017:7850708 pubmed publisher
    A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature...
  69. Sarkar S, Ryan E, Royle S. FGFR3-TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle. Open Biol. 2017;7: pubmed publisher
    Fibroblast growth factor receptor 3-transforming acidic coiled-coil containing protein 3 (FGFR3-TACC3; FT3) is a gene fusion resulting from rearrangement of chromosome 4 that has been identified in many cancers including those of the ..
  70. Matsuda K, Miyoshi H, Hiraoka K, Yokoyama S, Haraguchi T, Hashiguchi T, et al. Clinicopathological and prognostic value of transforming acidic coiled-coil-containing protein 3 (TACC3) expression in soft tissue sarcomas. PLoS ONE. 2017;12:e0188096 pubmed publisher
    Transforming acidic coiled-coil-containing protein 3 (TACC3), a microtubule regulator, is associated with various cancers. However, the relationship between TACC3 and soft tissue sarcomas (STS) remains unclear...
  71. Kim J, Ha G, Campo L, Breuer E. Negative regulation of BRCA1 by transforming acidic coiled-coil protein 3 (TACC3). Biochem Biophys Res Commun. 2018;496:633-640 pubmed publisher
    ..Mounting evidence indicates that the transforming acidic coiled-coil 3 (TACC3) plays an important role in the centrosome-microtubule network during mitosis and gene expression, and that ..
  72. Tien A, Lin M, Su L, Hong Y, Cheng T, Lee Y, et al. Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol Cell Proteomics. 2004;3:93-104 pubmed
    ..Four potential Aurora substrates and/or interacting proteins, TACC3, survivin, Hec1, and hsNuf2, were identified and empirically validated...
  73. Mori D, Yano Y, Toyo oka K, Yoshida N, Yamada M, Muramatsu M, et al. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol. 2007;27:352-67 pubmed
    ..In addition, NDEL1 is required for centrosome targeting of TACC3 through the interaction with TACC3...
  74. Cyr A, Nimmakayalu M, Longmuir S, Patil S, Keppler Noreuil K, Shchelochkov O. A novel 4p16.3 microduplication distal to WHSC1 and WHSC2 characterized by oligonucleotide array with new phenotypic features. Am J Med Genet A. 2011;155A:2224-8 pubmed publisher
    ..oligonucleotide microarray, we have identified a novel submicroscopic duplication involving dosage sensitive genes TACC3, FGFR3, and LETM1...
  75. Zhu X, Cao Q, Li X, Wang Z. Knockdown of TACC3 inhibits trophoblast cell migration and invasion through the PI3K/Akt signaling pathway. Mol Med Rep. 2016;14:3437-42 pubmed publisher
    ..Transforming acidic coiled?coil protein 3 (TACC3), a member of the TACC domain family, is important in the regulation of cell differentiation, migration and ..
  76. Johnson A, Severson E, Gay L, Vergilio J, Elvin J, Suh J, et al. Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures. Oncologist. 2017;22:1478-1490 pubmed publisher
    ..Rearrangements were identified in 35% of pLGGs, including KIAA1549-BRAF, QKI-RAF1, FGFR3-TACC3, CEP85L-ROS1, and GOPC-ROS1 fusions. Among pHGGs, GA were identified in 96.8% (152/157)...
  77. Steadman B, Schmidt P, Shanks R, Lapierre L, Goldenring J. Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus. J Biol Chem. 2002;277:30165-76 pubmed publisher
    ..Two-hybrid binary assays demonstrate interaction of both TACC3 and TACC4 with AKAP350A and AKAP350B...
  78. Leonard D, Ajuh P, Lamond A, Legerski R. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. Biochem Biophys Res Commun. 2003;308:793-801 pubmed
    ..Although many members of the DExH/D helicase superfamily have been linked to pre-mRNA splicing, this is the first SNF2 family member to be implicated in this pathway. ..
  79. Blower M, Nachury M, Heald R, Weis K. A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell. 2005;121:223-34 pubmed
    ..Furthermore, we provide evidence that RNA associates with the mitotic spindle and that it plays a direct, translation-independent role in spindle assembly. Our studies reveal an unexpected function for RNA in spindle morphogenesis. ..
  80. Yuan L, Liu Z, Lin Z, Xu L, Zhong Q, Zeng M. Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma. Cancer Biol Ther. 2014;15:1613-21 pubmed publisher
    ..we found that fibroblast growth factor receptor 3-transforming acidic coiled-coil-containing protein 3 (FGFR3-TACC3) fusion transcripts are recurrently detected in NPC...
  81. Suhail T, Singh P, Manna T. Suppression of centrosome protein TACC3 induces G1 arrest and cell death through activation of p38-p53-p21 stress signaling pathway. Eur J Cell Biol. 2015;94:90-100 pubmed publisher
    The centrosome regulates diverse cellular processes, including cell proliferation and differentiation. TACC3, a member of the human transforming acidic coiled-coil protein family, is a key centrosomal protein that is up-regulated in many ..
  82. Granberg K, Annala M, Lehtinen B, Kesseli J, Haapasalo J, Ruusuvuori P, et al. Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas. Neuro Oncol. 2017;19:1206-1216 pubmed publisher
    ..Gene fusions involving FGFR3 and transforming acidic coiled-coil protein 3 (TACC3) have been detected in diffuse gliomas and other malignancies, and fusion-positive cases have responded well to ..
  83. Thakur H, Singh M, Nagel Steger L, Prumbaum D, Fansa E, Gremer L, et al. Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division. Biol Chem. 2013;394:1411-23 pubmed publisher
    ..on members of the transforming acidic coiled coil (TACC) family of centrosomal adaptor proteins, in particular TACC3, in which their subcellular localization at the mitotic spindle apparatus is controlled by Aurora-A kinase-..
  84. Figueroa J, Ye Y, Siddiq A, Garcia Closas M, Chatterjee N, Prokunina Olsson L, et al. Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet. 2014;23:1387-98 pubmed publisher
  85. Guo Y, Scheuermann T, Partch C, Tomchick D, Gardner K. Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization. J Biol Chem. 2015;290:7707-21 pubmed publisher
    ..with the C-terminal fragment of a coiled-coil coactivator protein, transforming acidic coiled-coil coactivator 3 (TACC3)...
  86. Yun M, Rong J, Lin Z, He Y, Zhang J, Peng Z, et al. High expression of transforming acidic coiled coil-containing protein 3 strongly correlates with aggressive characteristics and poor prognosis of gastric cancer. Oncol Rep. 2015;34:1397-405 pubmed publisher
    Transforming acidic coiled coil-containing protein 3 (TACC3) is well understood to regulate mitotic spindle dynamics and centrosome integrity during mitosis...
  87. Cheeseman L, Harry E, McAinsh A, Prior I, Royle S. Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. J Cell Sci. 2013;126:2102-13 pubmed publisher
    ..Here, we have used 'knocksideways' to rapidly (?5 minutes) and specifically remove TACC3-ch-TOG-clathrin non-motor complexes from kinetochore fibers (K-fibers)...
  88. Huang Z, Lin Z, Xiao Y, Cao X, Zhu L, Zeng M, et al. High expression of TACC3 in esophageal squamous cell carcinoma correlates with poor prognosis. Oncotarget. 2015;6:6850-61 pubmed
    To analyze the expression of the transforming acidic coiled-coil protein 3 (TACC3) in esophageal squamous cell carcinoma (ESCC) samples, and to identify whether TACC3 can serve as a biomarker for the diagnosis and prognosis of ESCC, qPCR,..
  89. Rothman N, Garcia Closas M, Chatterjee N, Malats N, Wu X, Figueroa J, et al. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010;42:978-84 pubmed publisher
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. ..
  90. Capelletti M, Dodge M, Ercan D, Hammerman P, Park S, Kim J, et al. Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma. Clin Cancer Res. 2014;20:6551-8 pubmed publisher
    ..7% of Asian and 31% of Caucasian tumor specimens. We identified a FGFR3-TACC3 fusion event in one of 24 patients from this subset using targeted NGS...
  91. Nelson K, Meyer A, Siari A, Campos A, Motamedchaboki K, Donoghue D. Oncogenic Gene Fusion FGFR3-TACC3 Is Regulated by Tyrosine Phosphorylation. Mol Cancer Res. 2016;14:458-69 pubmed publisher
    ..a frequently identified fusion protein between FGFR3 and transforming acidic coiled-coil containing protein 3 (TACC3), frequently identified in glioblastoma, lung cancer, bladder cancer, oral cancer, head and neck squamous cell ..
  92. Bielle F, Di Stefano A, Meyronet D, Picca A, Villa C, Bernier M, et al. Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features. Brain Pathol. 2017;: pubmed publisher
    ..Here, we report a series of 30 adult diffuse gliomas with an in frame FGFR3-TACC3 oncogenic fusion (n?=?27 WHO grade IV and n?=?3 WHO grade II) as well as their histological and molecular features...