Gene Symbol: TAC3
Description: tachykinin 3
Alias: HH10, NKB, NKNB, PRO1155, ZNEUROK1, tachykinin-3, gamma tachykinin 3, neurokinin b, neuromedin K, preprotachykinin B
Species: human
Products:     TAC3

Top Publications

  1. Rance N, Young W. Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women. Endocrinology. 1991;128:2239-47 pubmed
    ..35S-labeled cDNA probes complementary to mRNAs encoding estrogen receptor, substance-P (SP), neurokinin-B (NKB), POMC, cholecystokinin, dynorphin, CRF, enkephalin, galanin, neuropeptide-Y, GH-releasing hormone, and tyrosine ..
  2. Page N, Woods R, Gardiner S, Lomthaisong K, Gladwell R, Butlin D, et al. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. Nature. 2000;405:797-800 pubmed
    ..a precursor protein of 121 amino acids which gives rise to a mature peptide identical to the neuropeptide neurokinin B (NKB) of other mammalian species...
  3. Page N, Woods R, Lowry P. A regulatory role for neurokinin B in placental physiology and pre-eclampsia. Regul Pept. 2001;98:97-104 pubmed
    Tachykinin dogma has assumed, so far, that neurokinin B (NKB) is a neuropeptide that is not produced in any peripheral tissue even though its endogenous receptor, NK3, has been found in a number of locations throughout the human body...
  4. Brownbill P, Bell N, Woods R, Lowry P, Page N, Sibley C. Neurokinin B is a paracrine vasodilator in the human fetal placental circulation. J Clin Endocrinol Metab. 2003;88:2164-70 pubmed
    ..There is recent evidence that NKB is expressed by the syncytiotrophoblast of the human placenta, an organ that is not innervated...
  5. Laliberte C, DiMarzo L, Morrish D, Kaufman S. Neurokinin B causes concentration-dependent relaxation of isolated human placental resistance vessels. Regul Pept. 2004;117:123-6 pubmed
    Placental neurokinin B (NKB) was recently identified as the causative agent in preeclampsia, a condition characterized by increased maternal and feto-placental vascular resistance...
  6. Page N, Dakour J, Morrish D. Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia. Mol Hum Reprod. 2006;12:427-33 pubmed
    Elevated circulating levels of the tachykinin, neurokinin B (NKB), have been observed in women with pre-eclampsia during the third trimester of pregnancy...
  7. Torricelli M, Giovannelli A, Leucci E, Florio P, De Falco G, Torres P, et al. Placental neurokinin B mRNA expression increases at preterm labor. Placenta. 2007;28:1020-3 pubmed
    b>Neurokinin B (NKB) is a neuropeptide belonging to the family of tachykinins-related peptides that elicits contractility of human myometrial strips in vitro...
  8. Tofa K, Gebhardt S, Rebello G, Geissbuehler V, Moser R, Stolk M, et al. Altered circulating neurokinin B (NKB) levels are not due to sequence variants in the encoding genes. Eur J Obstet Gynecol Reprod Biol. 2008;140:135-6 pubmed
  9. Geissbuehler V, Hillermann R, Czarniecki J, Gebhardt S, Forst S, Eberhard J, et al. Third trimester plasma neurokinin B levels in women with and without preeclampsia. J Matern Fetal Neonatal Med. 2008;21:95-100 pubmed publisher
    This study was undertaken to measure neurokinin B (NKB) levels in pregnant women with and without preeclampsia (PE) in the third trimester...

More Information

Publications136 found, 100 shown here

  1. Topaloglu A, Reimann F, Guclu M, Yalin A, Kotan L, Porter K, et al. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nat Genet. 2009;41:354-358 pubmed publisher
    ..failure in which all affected individuals are homozygous for loss-of-function mutations in TAC3 (encoding Neurokinin B) or its receptor TACR3 (encoding NK3R)...
  2. Li Z, Zhao Y, Chen Q, Zou L, Wang Z. [Relationship between neurokinin B and endothelin-1 and hypertensive disorders complicating pregnancy]. Zhonghua Fu Chan Ke Za Zhi. 2008;43:584-8 pubmed
    To investigate the relationship between neurokinin B (NKB), endothelin-1 (ET-1) and the pathogenesis of hypertensive disorder complicating pregnancy (HDCP)...
  3. Young J, Bouligand J, Francou B, Raffin Sanson M, Gaillez S, Jeanpierre M, et al. TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans. J Clin Endocrinol Metab. 2010;95:2287-95 pubmed publisher
    Missense loss-of-function mutations in TAC3 and TACR3, the genes encoding neurokinin B and its receptor NK3R, respectively, were recently discovered in kindreds with nonsyndromic normosmic congenital hypogonadotropic hypogonadism (CHH), ..
  4. Gianetti E, Tusset C, Noel S, Au M, Dwyer A, Hughes V, et al. TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab. 2010;95:2857-67 pubmed publisher
    Mutations in TAC3 and TACR3 (encoding neurokinin B and its receptor) have been identified in Turkish patients with idiopathic hypogonadotropic hypogonadism (IHH), but broader populations have not yet been tested and genotype-phenotype ..
  5. Hrabovszky E, Sipos M, Molnár C, Ciofi P, Borsay B, Gergely P, et al. Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept. Endocrinology. 2012;153:4978-89 pubmed
    ..and in situ hybridization studies of sheep, goats, and rodents indicated that kisspeptin (KP), neurokinin B (NKB), and dynorphin A (DYN) are extensively colocalized in the hypothalamic arcuate nucleus, thus providing a ..
  6. Molnár C, Vida B, Sipos M, Ciofi P, Borsay B, Rácz K, et al. Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. Endocrinology. 2012;153:5428-39 pubmed publisher
    Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons...
  7. Hrabovszky E, Borsay B, Rácz K, Herczeg L, Ciofi P, Bloom S, et al. Substance P immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region. PLoS ONE. 2013;8:e72369 pubmed publisher
    Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate nucleus represent important upstream regulators of pulsatile gonadotropin-releasing hormone (GnRH) neurosecretion...
  8. Hrabovszky E, Ciofi P, Vida B, Horvath M, Keller E, Caraty A, et al. The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons. Eur J Neurosci. 2010;31:1984-98 pubmed publisher
    ..ii) sexual dimorphism, (iii) relationship to gonadotropin-releasing hormone (GnRH) neurons and (iv) neurokinin B content of kisspeptin-immunoreactive hypothalamic neurons in human autopsy samples...
  9. Rance N, Krajewski S, Smith M, Cholanian M, Dacks P. Neurokinin B and the hypothalamic regulation of reproduction. Brain Res. 2010;1364:116-28 pubmed publisher
    Loss-of-function mutations in the genes encoding either neurokinin B (NKB) or its receptor, NK3 (NK3R), result in hypogonadotropic hypogonadism, characterized by an absence of pubertal development and low circulating levels of LH and ..
  10. Maguire C, Song Y, Wu M, Leon S, Carroll R, Alreja M, et al. Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse. Endocrinology. 2017;158:2319-2329 pubmed publisher
    ..Unexpectedly, the response of Tac1-/- mice to central kisspeptin or senktide (neurokinin B receptor-agonist) administration was significantly decreased compared with controls, despite the preserved ..
  11. Eghlidi D, Garyfallou V, Kohama S, Urbanski H. Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques. J Mol Endocrinol. 2017;59:141-149 pubmed publisher
    ..in females, we did not find a significant age-associated increase in KISS1 (Kisspeptin) or TAC3 (Neurokinin B) expression in the ARC of males, most likely because the attenuation of circulating sex-steroid levels in the ..
  12. Padilla S, Johnson C, Barker F, Patterson M, Palmiter R. A Neural Circuit Underlying the Generation of Hot Flushes. Cell Rep. 2018;24:271-277 pubmed publisher
    ..Neurons in the arcuate nucleus of the hypothalamus that express kisspeptin and neurokinin B (Kiss1ARH neurons) are candidates for mediating hot flushes because they are negatively regulated by ..
  13. Skorupskaite K, George J, Veldhuis J, Anderson R. Neurokinin B regulates gonadotropin secretion, ovarian follicle growth and the timing of ovulation in healthy women. J Clin Endocrinol Metab. 2017;: pubmed publisher
    b>Neurokinin B (NKB) is obligate for human puberty, but its role in adult female gonadotropin secretion and ovarian follicle growth is unknown.
  14. Renukanthan A, Quinton R, Turner B, MacCallum P, Seal L, Davies A, et al. Kallmann syndrome patient with gender dysphoria, multiple sclerosis, and thrombophilia. Endocrine. 2015;50:496-503 pubmed publisher
    ..were negative for mutations in CHD7, FGF8, FGFR1, GNRH1, GNRHR, HS6ST1, KAL1, KISS1R, KISS1, NELF, PROK2, PROKR2, TAC3, and TACR3. The patient initially declined testosterone therapy with a view to undergo gender reassignment...
  15. Juiz N, Torrejón I, Burgos M, Torres A, Duffy T, Cayo N, et al. Alterations in Placental Gene Expression of Pregnant Women with Chronic Chagas Disease. Am J Pathol. 2018;188:1345-1353 pubmed publisher
    ..KISS1 and CGB5 were down-regulated, whereas KIF12, HLA-G, PRG2, TAC3, FN1, and ATXN3L were up-regulated...
  16. Yang J, Mamounis K, Yasrebi A, Roepke T. Regulation of gene expression by 17β-estradiol in the arcuate nucleus of the mouse through ERE-dependent and ERE-independent mechanisms. Steroids. 2016;107:128-38 pubmed publisher
    ..Furthermore, the NKB receptor, Tac3r, was suppressed by E2B in WT and KIKO females but not ERKO females, suggesting that ERα-..
  17. Marraudino M, Miceli D, Farinetti A, Ponti G, Panzica G, Gotti S. Kisspeptin innervation of the hypothalamic paraventricular nucleus: sexual dimorphism and effect of estrous cycle in female mice. J Anat. 2017;230:775-786 pubmed publisher
    ..in AVPV (with a higher signal in estrus) and ARC, and the strong co-localization between kisspeptin and NkB only in ARC and not in PVN suggested that the majority of the kisspeptin fibers found in the PVN might arise ..
  18. Dickinson S, Griffin B, Elmore M, Kriese Anderson L, Elmore J, Dyce P, et al. Transcriptome profiles in peripheral white blood cells at the time of artificial insemination discriminate beef heifers with different fertility potential. BMC Genomics. 2018;19:129 pubmed publisher
    ..expression levels between AI-pregnant and non-pregnant heifers yielded six DEGs (ALAS2, CNKSR3, LOC522763, SAXO2, TAC3, TFF2, eFDR?0.05)...
  19. Garcia A, Bezner K, Depena C, Yin W, Gore A. The effects of long-term estradiol treatment on social behavior and gene expression in adult female rats. Horm Behav. 2017;87:145-154 pubmed publisher
    ..nucleus (Pgr), bed nucleus of the stria terminalis (Oxtr, Esr2, Dnmt3a), and medial amygdala (Oxtr, Ar, Foxp1, Tac3)...
  20. Altmäe S, Segura M, Esteban F, Bartel S, Brandi P, Irmler M, et al. Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome. PLoS ONE. 2017;12:e0169223 pubmed publisher
    ..pathway and dysregulation of several genes including CCL2, FSTL3, IGFBP1, MMP12, PRG2, PRL, QSOX1, SERPINE2 and TAC3. Our global gene expression profiling approach demonstrates that maternal obesity creates a unique in utero ..
  21. Lomniczi A, Wright H, Castellano J, Matagne V, Toro C, Ramaswamy S, et al. Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression. Nat Commun. 2015;6:10195 pubmed publisher
    ..GATAD1 represses transcription of two key puberty-related genes, KISS1 and TAC3, directly, and reduces the activating histone mark H3K4me2 at each promoter via recruitment of histone demethylase ..
  22. Ortiz Cabrera N, Riveiro Alvarez R, Lopez Martinez M, Pérez Segura P, Aragón Gómez I, Trujillo Tiebas M, et al. Clinical Exome Sequencing Reveals MKRN3 Pathogenic Variants in Familial and Nonfamilial Idiopathic Central Precocious Puberty. Horm Res Paediatr. 2017;87:88-94 pubmed publisher
    ..75 years of age. We did not find any pathogenic variants in KISS1, KISS1R, LIN28, GNRH, GNRHR, TACR3, and TAC3. MKRN3 is the most frequent genetic cause of familial ICPP, so it is wise to screen for MKRN3 mutations in all ..
  23. Jovanovic I, Zivkovic M, Kostic M, Krstic Z, Djuric T, Licastro D, et al. Transcriptome-driven integrative exploration of functional state of ureter tissue affected by CAKUT. Life Sci. 2018;212:1-8 pubmed publisher
    ..By qRT-PCR the substantial increase of LCN2, PROM1, SOSTDC1, and decrease of INA, RASD1 and TAC3 mRNA levels was confirmed...
  24. Nguyen T, Baumgarth N. Innate B Cells Tell ILC How It's Done. Immunity. 2016;45:8-10 pubmed publisher
    ..In this issue of Immunity, Fan and colleagues now demonstrate that even earlier responding innate-like B cells (NKB) induce these protective ILC responses.
  25. Singh V, Singh L, Vasudevan M, Chattopadhyay I, Borthakar B, Rai A, et al. Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population. OMICS. 2015;19:688-99 pubmed publisher
    ..SEMG2, CD97, CTNND2, CADM3, OMD, NEFM, FBN2, CTNNB1, DLX6, UGT2B4, CCDC80, PZP, SERPINA4, TNFSF13B, NPC1, COL1A1, TAC3, BMP8A, and IL22RA2) with promoter hypomethylation and upregulation...
  26. Skorupskaite K, George J, Veldhuis J, Millar R, Anderson R. Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women. Neuroendocrinology. 2018;106:148-157 pubmed publisher
    b>Neurokinin B (NKB) and kisspeptin are obligate for normal gonadotropin secretion, and links between gonadotropin-releasing hormone (GnRH) pulsatility and vasomotor symptoms have been proposed...
  27. Nakamura S, Ito Y, Yamamoto K, Takahashi C, Dai M, Tanahashi M, et al. SB223412, a neurokinin-3 receptor-selective antagonist, suppresses testosterone secretion in male guinea pigs. Theriogenology. 2017;102:183-189 pubmed publisher
    ..The mechanism generating GnRH/LH pulses is thought to be governed by kisspeptin neurons, which coexpress neurokinin B (NKB) and dynorphin A (Dyn), in the arcuate nucleus (ARC)...
  28. Li Q, Millar R, Clarke I, Smith J. Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep. Neuroendocrinology. 2015;101:161-74 pubmed publisher
    Loss-of-function mutations in genes encoding kisspeptin or neurokinin B (NKB) or their receptors cause infertility...
  29. Xu H, Niu Y, Wang T, Liu S, Xu H, Wang S, et al. Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate. Biomed Res Int. 2015;2015:649698 pubmed publisher
    ..for 15 known causal IHH genes (KAL1, FGFR1, NELF, FGF8, CHD7, WDR11, SEMA3A, KISS1R, KISS1, PROKR2, PROK2, TAC3, TACR3, GNRH1, and GNRHR) in four KS with CLP patients and six IHH patients without CLP...
  30. Kang M, Oh Y, Shim Y, Baek J, Yang S, Hwang I. The usefulness of circulating levels of leptin, kisspeptin, and neurokinin B in obese girls with precocious puberty. Gynecol Endocrinol. 2018;34:627-630 pubmed publisher
    This study investigated the relationships of circulating leptin, kisspeptin, and neurokinin B (NKB) levels with precocious puberty (PP) in overweight/obese girls and evaluated the usefulness of these markers in the initiation of puberty...
  31. Ruiz Pino F, Garcia Galiano D, Manfredi Lozano M, Leon S, Sánchez Garrido M, Roa J, et al. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology. 2015;156:576-88 pubmed publisher
    Kisspeptin/neurokinin B/dynorphin (KNDy) neurons, which coexpress kisspeptins (Kps), neurokinin B (NKB), and dynorphin (Dyn), regulate gonadotropin secretion...
  32. Fergani C, Routly J, Jones D, Pickavance L, Smith R, Dobson H. KNDy neurone activation prior to the LH surge of the ewe is disrupted by LPS. Reproduction. 2017;154:281-292 pubmed publisher
    ..dopamine-, β-endorphin- or neuropeptide Y (NPY)-expressing cells, as well as those co-localising kisspeptin, neurokinin B (NKB) and dynorphin (termed KNDy)...
  33. Skorupskaite K, George J, Veldhuis J, Millar R, Anderson R. Neurokinin 3 receptor antagonism decreases gonadotropin and testosterone secretion in healthy men. Clin Endocrinol (Oxf). 2017;87:748-756 pubmed publisher
    Patients with mutations of neurokinin B (NKB) and its receptor show hypogonadotrophic hypogonadism, but there is little evidence for the importance of this pathway in reproductive function in normal men, or its functional hierarchy with ..
  34. Oishi S, Fujii N. Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin-3 receptor (NK3R) ligands. Biopolymers. 2016;106:588-97 pubmed publisher
    ..b>Neurokinin B (NKB) is a member of the tachykinin family of neuropeptides and positively regulates pulsatile GnRH secretion...
  35. Blasco V, Pinto F, Fernández Atucha A, Prados N, Tena Sempere M, Fernández Sánchez M, et al. Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome. J Assist Reprod Genet. 2019;36:113-120 pubmed publisher
    The neurokinin B (NKB)/NK3 receptor (NK3R) and kisspeptin (KISS1)/kisspeptin receptor (KISS1R), two systems essential for reproduction, are present in human granulosa cells (GCs) of healthy women and contribute to the control ..
  36. Ikegami K, Minabe S, Ieda N, Goto T, Sugimoto A, Nakamura S, et al. Evidence of involvement of neurone-glia/neurone-neurone communications via gap junctions in synchronised activity of KNDy neurones. J Neuroendocrinol. 2017;29: pubmed publisher
    ..A cohort of neurones expressing three neuropeptides, namely kisspeptin, encoded by the Kiss1 gene, neurokinin B (NKB) and dynorphin A, localised in the hypothalamic arcuate nucleus (ARC), so-called KNDy neurones, comprises ..
  37. Young J, George J, Tello J, Francou B, Bouligand J, Guiochon Mantel A, et al. Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications. Neuroendocrinology. 2013;97:193-202 pubmed publisher
    ..Kisspeptin and neurokinin B (NKB), neuropeptides secreted by the same neuronal population in the ventral hypothalamus, have emerged ..
  38. Yamamura T, Wakabayashi Y, Ohkura S, Navarro V, Okamura H. Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and luteinizing hormone secretion in goats. J Reprod Dev. 2015;61:20-9 pubmed publisher
    Recent evidence suggests that neurokinin B (NKB), a member of the neurokinin (tachykinin) peptide family, plays a pivotal role in gonadotropin-releasing hormone (GnRH) pulse generation...
  39. Murakawa H, Iwata K, Takeshita T, Ozawa H. Immunoelectron microscopic observation of the subcellular localization of kisspeptin, neurokinin B and dynorphin A in KNDy neurons in the arcuate nucleus of the female rat. Neurosci Lett. 2016;612:161-166 pubmed publisher
    KNDy neurons are named for their co-expression of three neuropeptides, kisspeptin, neurokinin B (NKB) and dynorphin A (DynA)...
  40. Grachev P, Porter K, Coolen L, McCosh R, Connors J, Hileman S, et al. Surge-Like Luteinising Hormone Secretion Induced by Retrochiasmatic Area NK3R Activation is Mediated Primarily by Arcuate Kisspeptin Neurones in the Ewe. J Neuroendocrinol. 2016;28: pubmed publisher
    The neuropeptides neurokinin B (NKB) and kisspeptin are potent stimulators of gonadotrophin-releasing hormone (GnRH)/luteinsing hormone (LH) secretion and are essential for human fertility...
  41. Dissen G, Adachi K, Lomniczi A, Chatkupt T, Davidson B, Nakai H, et al. Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update. Reprod Domest Anim. 2017;52 Suppl 2:354-358 pubmed publisher
    ..We selected the hypothalamus because it contains neurons expressing Kiss1 and Tac3, two genes essential for reproduction and fertility...
  42. Cholanian M, Krajewski Hall S, McMullen N, Rance N. Chronic oestradiol reduces the dendritic spine density of KNDy (kisspeptin/neurokinin B/dynorphin) neurones in the arcuate nucleus of ovariectomised Tac2-enhanced green fluorescent protein transgenic mice. J Neuroendocrinol. 2015;27:253-63 pubmed publisher
    Neurones in the arcuate nucleus that express neurokinin B (NKB), kisspeptin and dynorphin (KNDy) play an important role in the reproductive axis...
  43. Newton C, Anderson R, Millar R. Therapeutic Neuroendocrine Agonist and Antagonist Analogs of Hypothalamic Neuropeptides as Modulators of the Hypothalamic-Pituitary-Gonadal Axis. Endocr Dev. 2016;30:106-29 pubmed publisher
    ..The novel neuroendocrine peptides, kisspeptin (KP) and neurokinin B (NKB), were recently discovered as upstream regulators of GnRH, and inactivating mutations of KP and NKB ..
  44. Hua W, Luo L, Tian Y, Song M, Liu Y, Cui P, et al. Analysis of the serum concentrations of kisspeptin and neurokinin B in the geese during reproductive cycle and their localisation in the ovary. Anim Reprod Sci. 2014;151:78-84 pubmed publisher
    Kisspeptin and neurokinin B (NKB) have various functions. Their expression has been demonstrated in rat and human ovary, and estrogen affects their activity, suggesting a role for these molecules in the control of ovary function...
  45. Rance N. Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides. 2009;30:111-22 pubmed publisher
    ..menopause is accompanied by hypertrophy of neurons in the infundibular (arcuate) nucleus expressing KiSS-1, neurokinin B (NKB), substance P, dynorphin and estrogen receptor alpha (ERalpha) mRNA...
  46. Navarro V, Bosch M, Leon S, Simavli S, True C, Pinilla L, et al. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 2015;156:627-37 pubmed publisher
    Tachykinins are comprised of the family of related peptides, substance P (SP), neurokinin A (NKA), and neurokinin B (NKB)...
  47. Rodríguez Fuentes N, Reynoso Ducoing O, Rodríguez Hernández A, Ambrosio Hernández J, Piña Barba M, Zepeda Rodríguez A, et al. Isolation of human mesenchymal stem cells and their cultivation on the porous bone matrix. J Vis Exp. 2015;:e51999 pubmed publisher
    ..option for the delivery of MSCs from human amniotic membrane (AM-hMSCs) that employs bovine bone matrix Nukbone (NKB) as a scaffold...
  48. Weems P, Lehman M, Coolen L, Goodman R. The Roles of Neurokinins and Endogenous Opioid Peptides in Control of Pulsatile LH Secretion. Vitam Horm. 2018;107:89-135 pubmed publisher
    ..nucleus (ARC) that contains two stimulatory neuropeptides, critical for fertility in humans (kisspeptin and neurokinin B (NKB)) and the inhibitory endogenous opioid peptide (EOP), dynorphin, and are now known as KNDy (kisspeptin-NKB-..
  49. Zelikowsky M, Hui M, Karigo T, Choe A, Yang B, Blanco M, et al. The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Cell. 2018;173:1265-1279.e19 pubmed publisher
    ..multiple behavioral changes in mice and induced brain-wide upregulation of the neuropeptide tachykinin 2 (Tac2)/neurokinin B (NkB)...
  50. Pineda R, Sabatier N, Ludwig M, Millar R, Leng G. A Direct Neurokinin B Projection from the Arcuate Nucleus Regulates Magnocellular Vasopressin Cells of the Supraoptic Nucleus. J Neuroendocrinol. 2016;28: pubmed publisher
    Central administration of neurokinin B (NKB) agonists stimulates immediate early gene expression in the hypothalamus and increases the secretion of vasopressin from the posterior pituitary through a mechanism that depends on the ..
  51. Qi X, Zhou W, Li S, Liu Y, Ye G, Liu X, et al. Goldfish neurokinin B: Cloning, tissue distribution, and potential role in regulating reproduction. Gen Comp Endocrinol. 2015;221:267-77 pubmed publisher
    b>Neurokinin B (NKB) is a member of the tackykinin (TAC) family known to play a critical role in the neuroendocrine regulation of reproduction in mammals. However, its biological functions in teleosts are less clear...
  52. Ahn T, Fergani C, Coolen L, Padmanabhan V, Lehman M. Prenatal testosterone excess decreases neurokinin 3 receptor immunoreactivity within the arcuate nucleus KNDy cell population. J Neuroendocrinol. 2015;27:100-10 pubmed publisher
    ..In the ewe, neurones of the arcuate nucleus (ARC), which co-expresses kisspeptin, neurokinin B (NKB) and dynorphin (termed KNDy cells), play a key role in steroid feedback control of GnRH and show altered ..
  53. Merkley C, Coolen L, Goodman R, Lehman M. Evidence for Changes in Numbers of Synaptic Inputs onto KNDy and GnRH Neurones during the Preovulatory LH Surge in the Ewe. J Neuroendocrinol. 2015;27:624-35 pubmed publisher
    ..ARC kisspeptin cells that co-localise neurokinin B (NKB) and dynorphin (Dyn), are collectively referred to as KNDy (Kisspeptin/NKB/Dyn) neurones, and have been ..
  54. Kunimura Y, Iwata K, Ishigami A, Ozawa H. Age-related alterations in hypothalamic kisspeptin, neurokinin B, and dynorphin neurons and in pulsatile LH release in female and male rats. Neurobiol Aging. 2017;50:30-38 pubmed publisher
    ..Kisspeptin (encoded by Kiss1) neurons in the arcuate nucleus coexpress neurokinin B (Tac3) and dynorphin (Pdyn) and are critical for regulating the GnRH/LH pulse...
  55. Francou B, Paul C, Amazit L, Cartes A, Bouvattier C, Albarel F, et al. Prevalence of KISS1 Receptor mutations in a series of 603 patients with normosmic congenital hypogonadotrophic hypogonadism and characterization of novel mutations: a single-centre study. Hum Reprod. 2016;31:1363-74 pubmed publisher
    ..The GNRHR, tachykinin receptor 3 (TACR3), gonadotrophin-releasing hormone 1 (GNRH1), tachykinin 3 (TAC3) and KISS1 genes were also sequenced...
  56. Fergani C, Navarro V. Expanding the Role of Tachykinins in the Neuroendocrine Control of Reproduction. Reproduction. 2016;153:R1-R14 pubmed
    ..manner to drive GnRH pulses under the coordinated autosynaptic action of its cotransmitters, the tachykinin neurokinin B (NKB, stimulatory) and dynorphin (inhibitory)...
  57. Osuka S, Iwase A, Nakahara T, Kondo M, Saito A, Bayasula -, et al. Kisspeptin in the Hypothalamus of 2 Rat Models of Polycystic Ovary Syndrome. Endocrinology. 2017;158:367-377 pubmed publisher
    ..Kisspeptin is coexpressed with neurokinin B (NKB) in the arcuate nucleus (ARC), the center of the gonadotropin-releasing hormone pulse generator that is ..
  58. Hu G, Lin C, He M, Wong A. Neurokinin B and reproductive functions: "KNDy neuron" model in mammals and the emerging story in fish. Gen Comp Endocrinol. 2014;208:94-108 pubmed publisher
    In mammals, neurokinin B (NKB), the gene product of the tachykinin family member TAC3, is known to be a key regulator for episodic release of luteinizing hormone (LH)...
  59. Akkoyun D, Akyüz A, Alpsoy Å, Gürel A, Güler N, DeÄŸirmenci H, et al. Plasma urotensin II and neurokinin B levels in acute myocardial infarction and stable coronary artery disease. Anatol J Cardiol. 2015;15:628-33 pubmed publisher
    This aim of the study is to investigate whether there are possible plasma urotensin-II (U-II) and neurokinin B (NKB) level changes in patients with acute myocardial infarction (AMI) or not and plasma urotensin-II (U-II) and neurokinin B (..
  60. Laoharatchatathanin T, Terashima R, Yonezawa T, Kurusu S, Kawaminami M. Augmentation of Metastin/Kisspeptin mRNA Expression by the Proestrous Luteinizing Hormone Surge in Granulosa Cells of Rats: Implications for Luteinization. Biol Reprod. 2015;93:15 pubmed publisher
    Variations in mRNA levels and sources of metastin/kisspeptin, neurokinin B (NKB), dynorphin, and kisspeptin receptor GPR54 were examined in the ovaries of cycling rats...
  61. Qiu J, Nestor C, Zhang C, Padilla S, Palmiter R, Kelly M, et al. High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons. elife. 2016;5: pubmed publisher
    Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal development and fertility...
  62. Liu Y, Tang H, Xie R, Li S, Liu X, Lin H, et al. Genetic Evidence for Multifactorial Control of the Reproductive Axis in Zebrafish. Endocrinology. 2017;158:604-611 pubmed publisher
    ..luteinizing hormone beta (lh?) was not significantly altered whereas the expression of neuropeptide Y (npy), tachykinin 3 (tac3), and secretogranin-II (sgII) was significantly increased in the triple knockout mutant, suggesting that ..
  63. Saedi S, Khoradmehr A, Mohammad Reza J, Tamadon A. The role of neuropeptides and neurotransmitters on kisspeptin/kiss1r-signaling in female reproduction. J Chem Neuroanat. 2018;92:71-82 pubmed publisher
    ..In female rodent, the kisspeptin (encoded by kiss1 gene), neurokinin B (Tac3) and dynorphin neurons form the basis for the "KNDy neurons" in the arcuate nucleus and play a ..
  64. Gutierrez Mecinas M, Furuta T, Watanabe M, Todd A. A quantitative study of neurochemically defined excitatory interneuron populations in laminae I-III of the mouse spinal cord. Mol Pain. 2016;12: pubmed publisher
    ..SST, preprotachykinin B (PPTB, the precursor of NKB), neurotensin, PKCγ or calretinin were detected with antibodies, while cells ..
  65. Duque E, Mangas A, Salinas P, Diaz Cabiale Z, Narvaez J, Coveñas R. Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem. Brain Struct Funct. 2013;218:131-49 pubmed publisher
    ..In the human brainstem, the proenkephalin system was more widely distributed than the prodynorphin system, and the preprotachykinin A system (neurokinin A) was more widely distributed than the preprotachykinin B system (neurokinin B).
  66. Oride A, Kanasaki H, Mijiddorj T, Sukhbaatar U, Ishihara T, Kyo S. Regulation of kisspeptin and gonadotropin-releasing hormone expression in rat placenta: study using primary cultures of rat placental cells. Reprod Biol Endocrinol. 2015;13:90 pubmed publisher
    ..After stimulation with estradiol, GnRH, kisspeptin, and neurokinin B (NKB), changes in placental GnRH, kisspeptin, and human chorionic gonadotropin (hCG) mRNA expression were ..
  67. Warrington J. Placental ischemia increases seizure susceptibility and cerebrospinal fluid cytokines. Physiol Rep. 2015;3: pubmed publisher
    ..utero-placental perfusion, increases susceptibility to seizures, cerebrospinal fluid (CSF) inflammation, and neurokinin B (NKB) expression in brain and plasma...
  68. Mittelman Smith M, Krajewski Hall S, McMullen N, Rance N. Ablation of KNDy Neurons Results in Hypogonadotropic Hypogonadism and Amplifies the Steroid-Induced LH Surge in Female Rats. Endocrinology. 2016;157:2015-27 pubmed publisher
    In the human infundibular (arcuate) nucleus, a subpopulation of neurons coexpress kisspeptin and neurokinin B (NKB), 2 peptides required for normal reproductive function...
  69. Yu Y, Yu C, Yin T, Ou S, Sun X, Wen X, et al. Functionalized poly (ionic liquid) as the support to construct a ratiometric electrochemical biosensor for the selective determination of copper ions in AD rats. Biosens Bioelectron. 2017;87:278-284 pubmed publisher
    ..The specific recognition of Cu2+ was accomplished by employing neurokinin B (NKB) for the first time, which could bind to Cu2+ to form a [CuII(NKB)2] ..
  70. Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, et al. Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma. Anticancer Res. 2016;36:6335-6341 pubmed
    b>Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system...
  71. Kuo C, Pavlidis S, Loza M, Baribaud F, Rowe A, Pandis I, et al. T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED. Eur Respir J. 2017;49: pubmed publisher
    ..i>TSLPR), TAC2 (characterised by interferon-, tumour necrosis factor-?- and inflammasome-associated genes) and TAC3 (characterised by genes of metabolic pathways, ubiquitination and mitochondrial function)...
  72. Zmora N, Wong T, Stubblefield J, Levavi Sivan B, Zohar Y. Neurokinin B regulates reproduction via inhibition of kisspeptin in a teleost, the striped bass. J Endocrinol. 2017;233:159-174 pubmed publisher
    Kisspeptin and neurokinin B (NKB) are neuropeptides co-expressed in the mammalian hypothalamus and coordinately control GnRH signaling...
  73. Gómez Lizárraga K, Flores Morales C, Del Prado Audelo M, Álvarez Pérez M, Piña Barba M, Escobedo C. Polycaprolactone- and polycaprolactone/ceramic-based 3D-bioplotted porous scaffolds for bone regeneration: A comparative study. Mater Sci Eng C Mater Biol Appl. 2017;79:326-335 pubmed publisher
    ..The ceramics used for the composite were bovine bone filling Nukbone® (NKB), and hydroxyapatite (HA) with 5%, 10% or 20% wt. The scaffolds were fabricated in a cellular lattice structure (i...
  74. Dao D, Perez E, Teng Y, Dani J, De Biasi M. Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling. J Neurosci. 2014;34:4273-84 pubmed publisher
    ..NK1; L-732138, 10 ?m) and NK3 (SB222200, 2 ?m) antagonists and mimicked by NK1 (substance P, 100 nm) and NK3 (neurokinin B [NKB], 100 nm) agonists...
  75. Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, et al. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016;45:131-44 pubmed publisher
    ..Here we have shown that a lymphocyte subpopulation natural killer-like B (NKB) cells existed in spleen and mesenteric lymph nodes (MLNs)...
  76. Leka Emiri S, Chrousos G, Kanaka Gantenbein C. The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). J Endocrinol Invest. 2017;40:789-802 pubmed publisher
    ..that the secretion of GnRH is regulated by kisspeptin as well as by permissive or opposing signals mediated by neurokinin B and dynorphin...
  77. Toro C, Wright H, Aylwin C, Ojeda S, Lomniczi A. Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty. Nat Commun. 2018;9:57 pubmed publisher
    ..Preceding puberty, MLL1 changes the chromatin configuration at the promoters of Kiss1 and Tac3, two genes required for puberty to occur, from repressive to permissive...
  78. Chen H, Xiao L, Liu Y, Li S, Li G, Zhang Y, et al. Neurokinin B signaling in hermaphroditic species, a study of the orange-spotted grouper (Epinephelus coioides). Gen Comp Endocrinol. 2018;260:125-135 pubmed publisher
    b>Neurokinin B (NKB) plays important roles in the mammalian reproductive axis by modulating the release of gonadotropin-releasing hormone (GnRH) and gonadotropins...
  79. Silveira L, Tusset C, Latronico A. Impact of mutations in kisspeptin and neurokinin B signaling pathways on human reproduction. Brain Res. 2010;1364:72-80 pubmed publisher
    ..Since then, several loss-of-function mutations affecting the kisspeptin receptor and neurokinin B and its receptor were associated with sporadic and familial IHH without olfactory abnormalities or other ..
  80. Skorupskaite K, George J, Anderson R. Role of a neurokinin B receptor antagonist in the regulation of ovarian function in healthy women. Lancet. 2015;385 Suppl 1:S92 pubmed publisher
    Patients with loss-of-function mutation in neurokinin B (NKB) and its receptor show hypogonadotropic hypogonadism characterised by failure to progress through puberty, indicating the involvement of this newly described hypothalamic ..
  81. Hassaneen A, Naniwa Y, Suetomi Y, Matsuyama S, Kimura K, Ieda N, et al. Immunohistochemical characterization of the arcuate kisspeptin/neurokinin B/dynorphin (KNDy) and preoptic kisspeptin neuronal populations in the hypothalamus during the estrous cycle in heifers. J Reprod Dev. 2016;62:471-477 pubmed
    ..To characterize kisspeptin neurons in the bovine hypothalamus, the co-localizations of kisspeptin and neurokinin B (NKB) or kisspeptin and dynorphin A (Dyn) were examined...
  82. Narayanaswamy S, Prague J, Jayasena C, Papadopoulou D, Mizamtsidi M, Shah A, et al. Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men. J Clin Endocrinol Metab. 2016;101:3429-36 pubmed publisher
    A subpopulation of hypothalamic neurons colocalize three neuropeptides, namely kisspeptin, neurokinin B (NKB), and dynorphin, collectively termed KNDy neurons...
  83. Skorupskaite K, George J, Veldhuis J, Millar R, Anderson R. Interactions Between Neurokinin B and Kisspeptin in Mediating Estrogen Feedback in Healthy Women. J Clin Endocrinol Metab. 2016;101:4628-4636 pubmed
    Kisspeptin and neurokinin B (NKB) are obligate for normal gonadotropin secretion, but their hierarchy is unexplored in normal women. To investigate the interaction between kisspeptin and NKB on estrogen-regulated LH secretion...
  84. Weems P, Smith J, Clarke I, Coolen L, Goodman R, Lehman M. Effects of Season and Estradiol on KNDy Neuron Peptides, Colocalization With D2 Dopamine Receptors, and Dopaminergic Inputs in the Ewe. Endocrinology. 2017;158:831-841 pubmed publisher
    ..Recent findings suggest that kisspeptin/neurokinin B/dynorphin (KNDy) neurons of the arcuate nucleus (ARC) play a key role in conveying this negative feedback ..
  85. Wang T, Chen S, Wang S, Shi L, Wang C, Zhang J, et al. Targeting neurokinin-3 receptor: a novel anti-angiogenesis strategy for cancer treatment. Oncotarget. 2017;8:40713-40723 pubmed publisher
    ..Although Neurokinin B, the selective natural agonist of neurokinin-3 receptor, have been shown to exhibit anti-angiogenesis activity, ..
  86. Tian Y, Wu L, Oxender D, Chung F. The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. J Biol Chem. 1996;271:20250-7 pubmed
    ..The resulting chimeric receptors not only retained high affinities for their natural ligands substance P and neurokinin B but also exhibited surprisingly high affinities for other naturally occurring tachykinins including neurokinin ..
  87. Navarro V. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47 pubmed publisher
    ..Recently, the neuropeptides kisspeptin (encoded by Kiss1) and neurokinin B (NKB, encoded by TAC3 in humans and Tac2 in rodents) have been placed as essential gatekeepers of puberty...
  88. Shi G, Zeng Q, Zhao Z, Li W, Dou J. Variation of CD4+CD25+Foxp3+ Regulatory T Cells and Th17 Cells in the Peripheral Blood of Human Liver Allograft Patients With Long-term Survival. Transplant Proc. 2017;49:1834-1840 pubmed publisher
    ..who survived for 3-10 years were in the Tac2 group (n = 15), and those who survived for >10 years were in the Tac3 group (n = 12). Healthy individuals were recruited in the control group (n = 20)...
  89. Iwasa T, Matsuzaki T, Yano K, Yanagihara R, Mayila Y, Irahara M. The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats. Gynecol Endocrinol. 2018;34:437-441 pubmed publisher
    ..the administration of testosterone or estradiol suppressed the hypothalamic mRNA levels of kisspeptin and neurokinin B, both of which are positive regulators of GnRH, whereas it did not affect the hypothalamic mRNA levels of the ..
  90. Bonner T, Affolter H, Young A, Young W. A cDNA encoding the precursor of the rat neuropeptide, neurokinin B. Brain Res. 1987;388:243-9 pubmed
    ..a cDNA clone from a rat cerebral cortex library which encodes the 116 amino acid precursor of the neuropeptide, neurokinin B. The precursor has 68% amino acid homology to the bovine precursor and encodes a single peptide of the ..
  91. Brunelleschi S, Bordin G, Colangelo D, Viano I. Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis. Neuropeptides. 1998;32:215-23 pubmed
    ..namely NK1, NK2 and NK3, are known to preferentially interact with substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), respectively...
  92. Schlembach D, Scalera F, Fischer T, Marx S, Beinder E, Garfield R. Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women. Am J Obstet Gynecol. 2003;189:1418-22 pubmed
    The purpose of this study was to examine neurokinin B levels in serum from preeclamptic and normotensive and to investigate the role of neurokinin B in preeclampsia...