Gene Symbol: TAB2
Description: TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Alias: CHTD2, MAP3K7IP2, TAB-2, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, TAK1-binding protein 2, mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Species: human
Products:     TAB2

Top Publications

  1. Wang C, Deng L, Hong M, Akkaraju G, Inoue J, Chen Z. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature. 2001;412:346-51 pubmed
    ..Here we report the purification and identification of TRIKA2, which is composed of TAK1, TAB1 and TAB2, a protein kinase complex previously implicated in IKK activation through an unknown mechanism...
  2. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. 2000;5:649-58 pubmed
    ..Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6...
  3. Cheung P, Nebreda A, Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem J. 2004;378:27-34 pubmed
    ..protein kinase (TAK1), termed TAB3 (TAK1-binding protein-3), which shares 48% amino acid sequence identity with TAB2. Our results indicate that two distinct TAK1 complexes are present in cells...
  4. Singhirunnusorn P, Suzuki S, Kawasaki N, Saiki I, Sakurai H. Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem. 2005;280:7359-68 pubmed
    ..RNA interference and overexpression experiments demonstrated that TAK1-binding protein TAB1 and TAB2 were involved in the phosphorylation of TAK1, but they regulated TAK1 phosphorylation differentially...
  5. Kishida S, Sanjo H, Akira S, Matsumoto K, Ninomiya Tsuji J. TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes Cells. 2005;10:447-54 pubmed
    ..TAK1-binding protein 2 (TAB2) was previously identified as an adaptor that links TAK1 to an upstream signaling intermediate, tumor necrosis ..
  6. Broglie P, Matsumoto K, Akira S, Brautigan D, Ninomiya Tsuji J. Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway. J Biol Chem. 2010;285:2333-9 pubmed publisher
    ..TAK1-binding protein 2 (TAB2) and its closely related protein, TAB3, are binding partners of TAK1 and have previously been identified as ..
  7. Kim S, Shim J, Chun E, Lee K. Reciprocal inhibition between the transforming growth factor-?-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein kinase kinase kinases and its suppression by TAK1-binding protein 2 (TAB2), an adapter . J Biol Chem. 2012;287:3381-91 pubmed publisher
    ..kinase 1 (TAK1)-TAK1-binding protein 1 (TAB1) complex negatively regulates ASK1-mediated signaling, and TAB2 reciprocally regulates TAK1-induced NF-?B and apoptosis signal-regulating kinase 1 (ASK1)-mediated AP-1 activations ..
  8. Ishitani T, Takaesu G, Ninomiya Tsuji J, Shibuya H, Gaynor R, Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 2003;22:6277-88 pubmed
    ..TAK1, a MAPKKK, is critical for both IL-1- and TNF-induced activation of the NF-kappaB pathway. TAB2, a TAK1-binding protein, is involved in IL-1-induced NF-kappaB activation by physically linking TAK1 to TRAF6...
  9. Kanayama A, Seth R, Sun L, Ea C, Hong M, Shaito A, et al. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004;15:535-48 pubmed
    ..of NF-kappaB and IKK requires an upstream kinase complex consisting of TAK1 and adaptor proteins such as TAB1, TAB2, or TAB3...

More Information

Publications129 found, 100 shown here

  1. Ea C, Deng L, Xia Z, Pineda G, Chen Z. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell. 2006;22:245-57 pubmed
    ..These results reveal the biochemical mechanism underlying the essential signaling function of NEMO and provide direct evidence that signal-induced site-specific ubiquitination of RIP1 is required for IKK activation. ..
  2. Tian Y, Zhang Y, Zhong B, Wang Y, Diao F, Wang R, et al. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. J Biol Chem. 2007;282:16776-82 pubmed
    ..Various studies have suggested that two homologous and structurally related adapter proteins TAB2 and TAB3 play redundant roles in TNF- and IL-1-mediated NF-kappaB activation pathways...
  3. Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, et al. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 1996;272:1179-82 pubmed
    ..The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells...
  4. Thiefes A, Wolf A, Doerrie A, Grassl G, Matsumoto K, Autenrieth I, et al. The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. EMBO Rep. 2006;7:838-44 pubmed
    ..mutant YopP(C172A), also suppresses basal and interleukin-1-inducible activation of endogenous TAK1, TAB1 and TAB2. YopP does not affect the interaction of TAK1, TAB1 and TAB2 but inhibits autophosphorylation of TAK1 at Thr 187 ..
  5. Walsh M, Kim G, Maurizio P, Molnar E, Choi Y. TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLoS ONE. 2008;3:e4064 pubmed publisher
    ..TRAF6 is essential for formation and activation of a complex involving the kinase TAK1 and its adapters, TAB1 and TAB2. In order to assess independently the E3 ligase and ubiquitin substrate functions of TRAF6, we generated, ..
  6. Tareen S, Emerman M. Human Trim5? has additional activities that are uncoupled from retroviral capsid recognition. Virology. 2011;409:113-20 pubmed publisher
    ..homologs) has been shown to negatively regulate NF-kappaB activation by targeting upstream signaling intermediates TAB2 and TAB3 for degradation...
  7. Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya Tsuji J. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood. 2012;120:3846-57 pubmed publisher
    ..TAK1 binding proteins 1 and 2 (TAB1 and TAB2) are activators of TAK1, but their roles in embryonic TAK1 signaling have not been determined...
  8. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem. 2006;281:7863-72 pubmed
    ..Here we demonstrate that TAK1 mitogen-activated protein kinase kinase kinase and TAK1-binding protein 2 (TAB2), together with TRAF6, are recruited to LMP1 through its N-terminal transmembrane region...
  9. Windheim M, Stafford M, Peggie M, Cohen P. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase. Mol Cell Biol. 2008;28:1783-91 pubmed publisher
    ..Our data suggest a model in which the recruitment of the NEMO-IKK complex to K63-pUb-IRAK1 and the recruitment of the TAK1 complex to TRAF6 facilitate the TAK1-catalyzed activation of IKK by the TRAF6-IRAK1 complex. ..
  10. Xia Z, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009;461:114-9 pubmed publisher any target protein, directly activate TAK1 by binding to the ubiquitin receptor TAB2 (also known as MAP3K7IP2). This binding leads to autophosphorylation and activation of TAK1...
  11. Suzuki S, Singhirunnusorn P, Mori A, Yamaoka S, Kitajima I, Saiki I, et al. Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB. J Biol Chem. 2007;282:25177-81 pubmed
    ..Tax induced persistent overexpression of TAK1-binding protein 2 (TAB2), but not TAB3, which is essential for TAK1 activation...
  12. Oeckinghaus A, Wegener E, Welteke V, Ferch U, Arslan S, Ruland J, et al. Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. EMBO J. 2007;26:4634-45 pubmed
    ..Thus, our data demonstrate that induced Malt1 ubiquitination is critical for the engagement of CBM and IKK complexes, thereby directing TCR signals to the canonical NF-kappaB pathway. ..
  13. Scholz R, Sidler C, Thali R, Winssinger N, Cheung P, Neumann D. Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem. 2010;285:25753-66 pubmed publisher
    ..TAK1 autoactivation involves the interplay with TAK1-binding proteins (TAB), e.g. TAB1 and TAB2, and phosphorylation of several activation segment residues...
  14. Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, et al. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature. 2011;472:361-5 pubmed publisher
  15. Shi M, Deng W, Bi E, Mao K, Ji Y, Lin G, et al. TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. Nat Immunol. 2008;9:369-77 pubmed publisher
    ..that the tripartite-motif protein TRIM30alpha, a RING protein, was induced by TLR agonists and interacted with the TAB2-TAB3-TAK1 adaptor-kinase complex involved in the activation of transcription factor NF-kappaB...
  16. Rajput I, Ying H, Yajing S, Arain M, Weifen L, Ping L, et al. Saccharomyces boulardii and Bacillus subtilis B10 modulate TLRs and cytokines expression patterns in jejunum and ileum of broilers. PLoS ONE. 2017;12:e0173917 pubmed publisher
    ..Down streaming MyD88, TRAF6, TAB2 and NF-κB mRNA level noted higher, in the jejunum and ileum as compared to control group...
  17. Yong Kim S, Jeong S, Chah K, Jung E, Baek K, Kim S, et al. Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal. Mol Endocrinol. 2013;27:1958-68 pubmed publisher
    ..Through biochemical studies, we found that SIK1 and SIK3 interact with TGF-?-activated kinase 1-binding protein 2 (TAB2), and interrupt the functional complex of TAB2-TNF receptor-associated factor 6 (TRAF6)...
  18. Jermy A. Antiviral immunity: TRIM5 moonlights as a pattern recognition receptor. Nat Rev Microbiol. 2011;9:398 pubmed publisher
  19. Wang X, Jiang J, Lu Y, Shi G, Liu R, Cao Y. TAB2, an important upstream adaptor of interleukin-1 signaling pathway, is subject to SUMOylation. Mol Cell Biochem. 2014;385:69-77 pubmed publisher
    ..b>TAB2 (TAK1-binding protein 2) is an upstream adaptor protein in the IL-1 signaling pathway...
  20. Hu M, Xie X, Yang Q, Liao C, Ye W, Lin H, et al. TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms. J Immunol. 2015;195:4415-25 pubmed publisher
    ..signaling in IFN-β-primed immune cells, but not unprimed immune cells, by mediating degradation of Tab2 in a lysosomal-dependent process...
  21. Jeon J, Lee J, Park K, Byun H, Lee H, Lee Y, et al. Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. Biochem Pharmacol. 2014;89:515-25 pubmed publisher
    ..Taken together, the results suggest that the anti-IKK activity of brazilin is induced by targeting IKK upstream signaling components and subsequently disrupting proximal IL-1 receptor signaling complex formation. ..
  22. Avesani F, Romanelli M, Turci M, Di Gennaro G, Sampaio C, Bidoia C, et al. Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-?B activation. Virology. 2010;408:39-48 pubmed publisher
    ..We have compared the interaction of Tax-1 and Tax-2 with two key NF-?B signalling factors: TAK1-binding protein 2 (TAB2), an adaptor involved in the activation of TAK1 kinase, and RelA, the active subunit of the canonical RelA/p50 NF-?..
  23. de Silva S, Wu L. TRIM5 acts as more than a retroviral restriction factor. Viruses. 2011;3:1204-9 pubmed publisher
    ..Here we discuss the significance of these new findings in understanding TRIM5-mediated HIV restriction. ..
  24. Yao Q, Zhang L, Wan X, Chen J, Hu L, Ding X, et al. Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway. PLoS Pathog. 2014;10:e1004522 pubmed publisher
    ..methyltransferase that methylates a zinc-coordinating cysteine in the Npl4-like Zinc Finger (NZF) domains in TAB2/3 adaptors in the NF-κB pathway, but its mechanism of action and other human substrates are unknown...
  25. Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G. An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. Biochem Biophys Res Commun. 2009;381:412-7 pubmed publisher
    ..Conversely, knockdown of FBXW5 resulted in the prolonged activation of TAK1 upon IL-1beta stimulation. These results suggest that FBXW5 negatively regulates TAK1 in the IL-1beta signaling pathway. ..
  26. Weiss K, Applegate C, Wang T, Batista D. Familial TAB2 microdeletion and congenital heart defects including unusual valve dysplasia and tetralogy of fallot. Am J Med Genet A. 2015;167A:2702-6 pubmed publisher
    Haploinsufficiency of TAB2 was recently implicated as a cause for a variety of congenital heart defects...
  27. Moon G, Kim J, Min Y, Wi S, Shim J, Chun E, et al. Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling. Cell Signal. 2015;27:2524-33 pubmed publisher interrupting the complex between transforming growth factor beta-activated kinase 1 (TAK1) and TAK1 binding protein 2 (TAB2), which negatively regulates TAK1 activity...
  28. Vasilescu C, Ojala T, Brilhante V, Ojanen S, Hinterding H, Palin E, et al. Genetic Basis of Severe Childhood-Onset Cardiomyopathies. J Am Coll Cardiol. 2018;72:2324-2338 pubmed publisher
    ..on metabolic causes (PRKAG2, MRPL44, AARS2, HADHB, DNAJC19, PPA2, TAZ, BAG3), MAPK pathways (HRAS, PTPN11, RAF1, TAB2), development (NEK8 and TBX20), calcium signaling (JPH2, CALM1, CACNA1C), and the sarcomeric contraction cycle (..
  29. Sardi S, Murtie J, Koirala S, Patten B, Corfas G. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell. 2006;127:185-97 pubmed
    ..activation and presenilin-dependent cleavage of ErbB4, the receptor's intracellular domain forms a complex with TAB2 and the corepressor N-CoR...
  30. Cutrupi S, Reineri S, Panetto A, Grosso E, Caizzi L, Ricci L, et al. Targeting of the adaptor protein Tab2 as a novel approach to revert tamoxifen resistance in breast cancer cells. Oncogene. 2012;31:4353-61 pubmed publisher
    ..Under certain circumstances, as demonstrated in the case of interleukin-1? (IL-1?) treatment, the protein Tab2 interacts with ER?/NCoR and causes dismissal of NCoR from these genes, leading to loss of the antiproliferative ..
  31. Wang J, Li B, Ge P, Li J, Wang Q, Gao G, et al. Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. Nat Immunol. 2015;16:237-45 pubmed publisher
    ..Our findings reveal how pathogens subvert innate immunity by coopting host ubiquitin and suggest a potential tuberculosis treatment via targeting of ubiquitin-PtpA interfaces. ..
  32. Hu M, Yang Q, Zhang J, Liu S, Zhang Y, Lin H, et al. TRIM38 inhibits TNF?- and IL-1?-triggered NF-?B activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014;111:1509-14 pubmed publisher
    ..TRIM38 constitutively interacted with critical components TGF-?-activated kinase 1 (TAK1)-binding protein 2/3 (TAB2/3) and promoted lysosome-dependent degradation of TAB2/3 independent of its E3 ubiquitin ligase activity...
  33. Huang C, Xu J, Zhong W, Xia Z, Wang S, Cheng D, et al. Sox9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic state. Stem Cell Res Ther. 2017;8:60 pubmed publisher
    ..Sox9 predominantly acts as a transcriptional activator at proximal enhancers of Wnt4, Tab2, Sox4, and Fzd8, but also functions as a potential transcriptional inhibitor at a distant enhancer of Cdk1...
  34. Takaesu G, Kobayashi T, Yoshimura A. TGF?-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy. J Biochem. 2012;151:157-66 pubmed publisher
    Transforming growth factor ?-activated protein kinase 1 (TAK1)-binding protein 2 (TAB2) and its close homolog TAB3 are initially characterized as adapter proteins essential for TAK1 activation in response to interleukin-1? and tumour ..
  35. Brand J, Humphreys K, Thompson D, Li J, Eriksson M, Hall P, et al. Volumetric mammographic density: heritability and association with breast cancer susceptibility loci. J Natl Cancer Inst. 2014;106: pubmed publisher
    ..0 × 10(-6) and 8.9 × 10(-7), respectively) and rs9485372 (TAB2; P = 1.8 × 10(-5) and 1.8 × 10(-3), respectively)...
  36. Wu C, Hsiao Y, Yeh K, Tsou T, Chen C, Wu M, et al. Upregulation of microRNA-4417 and Its Target Genes Contribute to Nickel Chloride-promoted Lung Epithelial Cell Fibrogenesis and Tumorigenesis. Sci Rep. 2017;7:15320 pubmed publisher
    ..Nickel increased miR-4417 expression and decreased its target gene TAB2 expression...
  37. Jiang Z, Ninomiya Tsuji J, Qian Y, Matsumoto K, Li X. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol. 2002;22:7158-67 pubmed
    ..IRAK then brings TRAF6 to TAK1, TAB1, and TAB2, which are preassociated on the membrane before stimulation to form the membrane-associated complex II...
  38. Zhang X, Sanmun D, Hu L, Fadeel B, Ernberg I. Epstein-Barr virus-encoded LMP1 promotes cisplatin-induced caspase activation through JNK and NF-kappaB signaling pathways. Biochem Biophys Res Commun. 2007;360:263-8 pubmed
    ..The current data support the notion that LMP1 modifies stress-induced apoptosis in epithelial cells through molecular interactions downstream of its C-terminal signaling domain. ..
  39. van Wijk S, Fiskin E, Dikic I. Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors. Nat Protoc. 2013;8:1449-58 pubmed publisher
    ..procedure deals with designing and validating the binding selectivity of GFP-tagged K63- and linear-linked sensors (TAB2 NZF and NEMO UBAN, respectively) in vitro...
  40. Arch R, Gedrich R, Thompson C. Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. Genes Dev. 1998;12:2821-30 pubmed
  41. Yu Q, Minoda Y, Yoshida R, Yoshida H, Iha H, Kobayashi T, et al. HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein. Biochem Biophys Res Commun. 2008;365:189-94 pubmed
    ..In this report, we investigated the role of TAK1-binding protein 2 (TAB2) in Tax-mediated TAK1 activation...
  42. Kim S, Kwak J, Na H, Kim J, Ding Y, Choi M. Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. J Biol Chem. 2009;284:22285-96 pubmed publisher
    ..We also show that TRAF6 and TAB2 are required for the interaction of TAK1 with TbetaRI and TGF-beta1-induced TAK1 activation in mouse mesangial ..
  43. Karim Z, Vemana H, Khasawneh F. MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation. PLoS ONE. 2015;10:e0119363 pubmed publisher
    ..and the interaction of IKKγ and MALT1; abrogates SNARE formation, and the association of MALT1 with TAK1 and TAB2, which are upstream of the CBM complex...
  44. Hirata Y, Takahashi M, Morishita T, Noguchi T, Matsuzawa A. Post-Translational Modifications of the TAK1-TAB Complex. Int J Mol Sci. 2017;18: pubmed publisher
    ..status of TAK1 is tightly regulated by forming a complex with its binding partners, TAK1-binding proteins (TAB1, TAB2, and TAB3)...
  45. Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, et al. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-?. Nat Med. 2012;18:1077-86 pubmed publisher
    ..activation and inflammatory cytokine expression by targeting TGF-?-activated kinase 1/MAP3K7 binding protein 2 (TAB2), TAB3 and inhibitor of nuclear factor ?-B kinase subunit ? (IKK-?) and, consequently, represses autoimmune ..
  46. Tokarev A, Suarez M, Kwan W, Fitzpatrick K, Singh R, Guatelli J. Stimulation of NF-?B activity by the HIV restriction factor BST2. J Virol. 2013;87:2046-57 pubmed publisher
    ..HIV-1 Vpu counteracts each of these functions. ..
  47. Ji Y, Zhang P, Zhang X, Zhao Y, Deng K, Jiang X, et al. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Nat Commun. 2016;7:11267 pubmed publisher
    ..ROS, generated during hypertrophic progression, triggers TRAF6 auto-ubiquitination that facilitates recruitment of TAB2 and its binding to transforming growth factor beta-activated kinase 1 (TAK1), which, in turn, enables the direct ..
  48. Zhao Y, Wang H, Lu M, Qiao X, Sun B, Zhang W, et al. Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation. Mediators Inflamm. 2016;2016:6340457 pubmed publisher
    ..Specifically, the target genes regulated macrophage activation through the TRAF6-TAB2-TAK1-NIK/IKK-NF?B pathway...
  49. Yokota S, Okabayashi T, Yokosawa N, Fujii N. Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20. FASEB J. 2008;22:74-83 pubmed
    ..the infected cells, LPS treatment failed to induce the formation of active protein kinase complex containing TAK1, TAB2 and tumor necrosis factor receptor-associated factor 6 (TRAF6), dissociate from TLR complexes containing ..
  50. Shkoda A, Town J, Griese J, Romio M, Sarioglu H, Knöfel T, et al. The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. PLoS Biol. 2012;10:e1001376 pubmed publisher
    ..TNIK forms an activation-induced complex with the critical signaling mediators TRAF6, TAK1/TAB2, and IKK?, and mediates signalosome formation at LMP1...
  51. Lin Y, Luo Z. NLRP6 facilitates the interaction between TAB2/3 and TRIM38 in rheumatoid arthritis fibroblast-like synoviocytes. FEBS Lett. 2017;591:1141-1149 pubmed publisher
  52. Kim J, Kim B, Cai L, Choi H, Ohgi K, Tran C, et al. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature. 2005;434:921-6 pubmed
  53. Martin S, Wu Z, Gehlhaus K, Jones T, Zhang Y, Guha R, et al. RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. Curr Cancer Drug Targets. 2011;11:976-86 pubmed
    ..g. NF- κB, JNK, and p38 signaling). An analysis of TAK1 signaling pathway members revealed that the silencing of TAB2 also sensitizes MDA-MB-231 and HCT-116 cells towards CPT...
  54. Fujikawa H, Farooq M, Fujimoto A, Ito M, Shimomura Y. Functional studies for the TRAF6 mutation associated with hypohidrotic ectodermal dysplasia. Br J Dermatol. 2013;168:629-33 pubmed publisher
    ..the interaction of TRAF6 with transforming growth factor ?-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB 2) and ectodysplasin-A receptor-associated death domain protein (EDARADD)...
  55. Wauer T, Swatek K, Wagstaff J, Gladkova C, Pruneda J, Michel M, et al. Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. EMBO J. 2015;34:307-25 pubmed publisher
    ..While Lys63-linked poly-phosphoUb is recognized by the TAB2 NZF Ub binding domain (UBD), 10 out of 12 deubiquitinases (DUBs), including USP8, USP15 and USP30, are impaired in ..
  56. Li H, Yoon J, Won H, Ji H, Yuk H, Park K, et al. Isotrifoliol inhibits pro-inflammatory mediators by suppression of TLR/NF-κB and TLR/MAPK signaling in LPS-induced RAW264.7 cells. Int Immunopharmacol. 2017;45:110-119 pubmed publisher
    ..expression of TNF receptor associated factor 6, transforming growth factor beta-activated kinase 1 (TAK1), TAK1 binding protein 2 (TAB2), and TAB3...
  57. Yang Q, Kathiresan S, Lin J, Tofler G, O Donnell C. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. BMC Med Genet. 2007;8 Suppl 1:S12 pubmed
    ..Further study of additional strongly associated SNPs and linked regions may identify novel variants that influence the inter-individual variability in hemostatic factors and hematological phenotypes. ..
  58. Krishnan G, Chatterjee N. Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected]. Sci Rep. 2015;5:9887 pubmed publisher
    ..AEA lowers nuclear NF-κB and TAB2 for both variants while elevating IRAK1BP1 in activated Müller glia...
  59. Potter C, Cordell H, Barton A, Daly A, Hyrich K, Mann D, et al. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. Ann Rheum Dis. 2010;69:1315-20 pubmed publisher
    ..Validation of these findings in an independent cohort is now warranted. ..
  60. Lei X, Han N, Xiao X, Jin Q, He B, Wang J. Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex. J Virol. 2014;88:9830-41 pubmed publisher
    ..Here, we show that EV71 disables components of the TAB2 complex through the 3C protein...
  61. Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K. The K48-K63 Branched Ubiquitin Chain Regulates NF-?B Signaling. Mol Cell. 2016;64:251-266 pubmed publisher
    ..The K48-K63 branched linkage permits recognition by TAB2 but protects K63 linkages from CYLD-mediated deubiquitylation, thereby amplifying NF-?B signals...
  62. Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S, et al. MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. Nat Cell Biol. 2007;9:1419-27 pubmed
    ..In addition, MUC1-mediated activation of IKKbeta is dependent on TAK1 and TAB2. These findings indicate that MUC1 is important for physiological activation of IKKbeta and that overexpression of ..
  63. Liu X, Li H, Zhong B, Blonska M, Gorjestani S, Yan M, et al. USP18 inhibits NF-?B and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. J Exp Med. 2013;210:1575-90 pubmed publisher
    ..Our findings thus demonstrate a previously uncharacterized negative regulation of TAK1 activity during Th17 differentiation, suggesting that USP18 may be targeted to treat autoimmune diseases. ..
  64. Wade E, Daniel P, Jenkins Z, McInerney Leo A, Leo P, Morgan T, et al. Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia. Am J Hum Genet. 2016;99:392-406 pubmed publisher
    ..mutations in two genes-MAP3K7, encoding transforming growth factor ? (TGF-?)-activated kinase (TAK1), and TAB2, encoding TAK1-associated binding protein 2 (TAB2)...
  65. Min Y, Wi S, Kang J, Yang T, Park C, Park S, et al. Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6. Cell Death Dis. 2016;7:e2313 pubmed publisher
    ..The interaction between CRBN and TAK1 did not affect the association of the TAB1 and TAB2 proteins, which have pivotal roles in the activation of TAK1, whereas the CRBN-TRAF6 interaction critically ..
  66. Zhu J, Zhu F, Song W, Zhang B, Zhang X, Jin X, et al. Altered miR-370 expression in hepatic ischemia-reperfusion injury correlates with the level of nuclear kappa B (NF-?B) related factors. Gene. 2017;607:23-30 pubmed publisher
    ..Quantitative real-time PCR showed the levels of TAK1, TAB1, TAB2, IkB?, IKK?, p65 was elevated when improving the miR-370 levels, at the same time, Western blot showed the levels ..
  67. Sun J, Zhu X, Dong T, Zhang X, Liu Q, Li S, et al. An "up, no change, or down" system: Time-dependent expression of mRNAs in contused skeletal muscle of rats used for wound age estimation. Forensic Sci Int. 2017;272:104-110 pubmed publisher
    ..Levels of PUM2, TAB2, GJC1, and CHRNA1 mRNAs were detected in contused muscle using real-time PCR...
  68. Grimsey N, Aguilar B, Smith T, Le P, Soohoo A, Puthenveedu M, et al. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015;210:1117-31 pubmed publisher
    ..ligase and initiated recruitment of transforming growth factor-?-activated protein kinase-1 binding protein-2 (TAB2). The ubiquitin-binding domain of TAB2 was essential for recruitment to PAR1-containing endosomes...
  69. Simmonds M, Heward J, Carr Smith J, Foxall H, Franklyn J, Gough S. Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. J Clin Endocrinol Metab. 2006;91:1056-61 pubmed
    ..six DNA variants, two of which (M55V and 001Msp) are present in nuclear factor-kappaB inhibitors SUMO-4 and MAP3K7IP2 and four of which (fcrl3_3, fcrl3_4, fcrl3_5, and fcrl3_6) modulate nuclear factor-kappaB binding and production ..
  70. Brand J, Li J, Humphreys K, Karlsson R, Eriksson M, Ivansson E, et al. Identification of two novel mammographic density loci at 6Q25.1. Breast Cancer Res. 2015;17:75 pubmed publisher
    ..1, both of which are known breast cancer susceptibility loci: rs9485370 in the TAB2 gene (P = 4.8 × 10(-9) for percent MD and P = 2...
  71. Takagawa T, Kitani A, Fuss I, Levine B, Brant S, Peter I, et al. An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis. Sci Transl Med. 2018;10: pubmed publisher
    ..Next, we found that membrane-associated LRRK2 (in association with TAB2) caused inactivation of Beclin-1 and inhibition of autophagy...
  72. Zhuang Z, Sun L, Kong L, Hu J, Yu M, Reinach P, et al. Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB. Cell Signal. 2006;18:964-70 pubmed
    ..Activation of TAK1 in mammals is mediated by two TAK1-binding proteins, TAB1 and TAB2, but the role of the TAB proteins in the immune response of Drosophila has not yet been established...
  73. Qiu H, Huang F, Xiao H, Sun B, Yang R. TRIM22 inhibits the TRAF6-stimulated NF-?B pathway by targeting TAB2 for degradation. Virol Sin. 2013;28:209-15 pubmed publisher
    ..of TRAF6, and interact with and degrade transforming growth factor-? activated kinase 1 binding protein 2 (TAB2), and that these effects could be partially rescued by a TRIM22 RING domain deletion mutant...
  74. Sanna M, da Silva Correia J, Luo Y, Chuang B, Paulson L, Nguyen B, et al. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. J Biol Chem. 2002;277:30454-62 pubmed
  75. Komander D, Reyes Turcu F, Licchesi J, Odenwaelder P, Wilkinson K, Barford D. Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 2009;10:466-73 pubmed publisher
    ..essential modifier) binds to linear chains exclusively, whereas the NZF (Npl4 zinc finger) domain of TAB2 (TAK1 binding protein 2) is Lys 63 specific. Our results highlight remarkable specificity determinants within the ubiquitin system. ..
  76. Zhang X, Smits A, van Tilburg G, Jansen P, Makowski M, Ovaa H, et al. An Interaction Landscape of Ubiquitin Signaling. Mol Cell. 2017;65:941-955.e8 pubmed publisher
    ..UbIA-MS reveals linkage-selective diubiquitin interactions in multiple cell types. For example, we identify TAB2 and TAB3 as novel K6 diubiquitin interactors and characterize UCHL3 as a K27-linkage selective interactor that ..
  77. Morlino S, Castori M, Dordoni C, Cinquina V, Santoro G, Grammatico P, et al. A novel MAP3K7 splice mutation causes cardiospondylocarpofacial syndrome with features of hereditary connective tissue disorder. Eur J Hum Genet. 2018;26:582-586 pubmed publisher
    ..frontometaphyseal dysplasia also comprise variants in FLNA (type 1) and two patients with a heterozygous variant in TAB2 (type 3). We report on a 7-year-old girl with CSCFS due to the novel heterozygous c.737-7A>G variant in MAP3K7...
  78. Zhou Y, Wu P, Yuan X, Li J, Shi X. Interleukin-17A inhibits cell autophagy under starvation and promotes cell migration via TAB2/TAB3-p38 mitogen-activated protein kinase pathways in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 2016;20:250-63 pubmed
    ..inhibited starvation-induced autophagy and maintained cell viability through activating TAK1-binding protein 2 (TAB2 and TAK1-binding protein 3 (TAB3)-inducing p38 mitogen-activated protein kinase (MAPK) in Huh7 and HepG2 HCC cells...
  79. Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D. Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain. Nat Struct Mol Biol. 2009;16:1328-30 pubmed publisher
    The protein kinase TAK1 is activated by binding to Lys63 (K63)-linked ubiquitin chains through its subunit TAB2. Here we analyze crystal structures of the TAB2 NZF domain bound to Lys63-linked di- and triubiquitin, revealing that TAB2 ..
  80. Imaizumi T, Tanaka H, Tajima A, Yokono Y, Matsumiya T, Yoshida H, et al. IFN-? and TNF-? synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells. Am J Nephrol. 2010;32:462-8 pubmed publisher
    ..with miR-155 mimic, siRNA against transforming growth factor-?-activated kinase-1 (TAK1)-binding protein 2 (TAB2) or siRNA against nuclear factor-?B (NF-?B). IFN-? and TNF-? synergistically induced the expression of miR-155...
  81. Zhao L, Zhang Y. miR-342-3p affects hepatocellular carcinoma cell proliferation via regulating NF-κB pathway. Biochem Biophys Res Commun. 2015;457:370-7 pubmed publisher
    ..algorithms we found that miR-342-3p is related to the NF-κB pathway and luciferase assay found that IKK-γ, TAB2 and TAB3 are miR-342-3p target genes...
  82. Wang S, Li H, Qian Z, Song X, Zhang Z, Zuo H, et al. Identification and functional characterization of the TAB2 gene from Litopenaeus vannamei. Fish Shellfish Immunol. 2015;46:206-16 pubmed publisher
    In Drosophila, TAB2, an important intermediate in the IMD signaling pathway, plays critical roles in the innate immune response in response to bacterial and viral infection...
  83. Deacon K, Blank J. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem. 1997;272:14489-96 pubmed
    ..These observations suggest that regulation of p38 and JNK1 pathways by MEKK3 may involve distinct mechanisms to prevent p38 activation but to allow JNK1 activation. ..
  84. Owerbach D, Piña L, Gabbay K. A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes. Diabetes. 2004;53:1890-3 pubmed
    The IDDM5 gene, which is identified by whole-genome searches, is located on chromosome 6q25. TAB2 (MAP3K7IP2 [mitogen-activating protein kinase kinase kinase 7 interacting protein 2]) is a potential candidate gene for type 1 diabetes ..
  85. Morlon A, Smahi A, Munnich A. [New genes candidates for ectodermal dysplasia: TAB2, TRAF6 and TAK1]. Med Sci (Paris). 2006;22:229-30 pubmed
  86. Hong S, Lim S, Li A, Lee C, Lee Y, Lee E, et al. Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. Nat Immunol. 2007;8:504-13 pubmed
    ..Here we show that the TGF-beta-induced signaling protein Smad7 bound to TAB2 and TAB3, which are adaptors that link the kinase TAK1 to 'upstream' regulators in the proinflammatory tumor ..
  87. Niu J, Shi Y, Iwai K, Wu Z. LUBAC regulates NF-?B activation upon genotoxic stress by promoting linear ubiquitination of NEMO. EMBO J. 2011;30:3741-53 pubmed publisher
    ..Therefore, LUBAC-dependent NEMO linear ubiquitination is critical for genotoxic NF-?B activation and protects cells from DNA damage-induced apoptosis. ..
  88. Li W, Zhu H, Zhao X, Brancho D, Liang Y, Zou Y, et al. Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein. Mol Cell Biol. 2015;35:2464-78 pubmed
    ..We propose that altered endosomal trafficking due to malformations of MVBs and subsequent atypical signaling kinetic may account for a toxic gain of function in CMT1C pathogenesis. ..
  89. Zhang J, MacArtney T, Peggie M, Cohen P. Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. Biochem J. 2017;474:2235-2248 pubmed publisher activate the 'master' protein kinase TGFβ-activated kinase 1 (TAK1) by interacting with its TAK1-binding 2 (TAB2) and TAB3 subunits...
  90. Liu X, Seh C, Cheung P. HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway. FEBS Lett. 2008;582:4023-31 pubmed publisher
    ..Our results suggest that Hsp90 is required for the folding and stability of TAK1 but is displaced and no longer required when TAK1 is complexed to TAK1-binding protein-1 (TAB1). ..
  91. Gao D, Wang R, Li B, Yang Y, Zhai Z, Chen D. WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. Cell Mol Life Sci. 2009;66:2573-84 pubmed publisher
    ..WDR34 interacted with TAK1, TAK1-binding protein 2 (TAB2), TAK1-binding protein 3 (TAB3) and tumor necrosis factor receptor-associated factor 6 (TRAF6) in overexpression ..
  92. Thienpont B, Zhang L, Postma A, Breckpot J, Tranchevent L, Van Loo P, et al. Haploinsufficiency of TAB2 causes congenital heart defects in humans. Am J Hum Genet. 2010;86:839-49 pubmed publisher
    ..genes in this locus for a role in CHDs identified the TGF-beta-activated kinase 1/MAP3K7 binding protein 2 gene (TAB2) as the top-ranking candidate gene...