Gene Symbol: TAB1
Description: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Alias: 3'-Tab1, MAP3K7IP1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, TAK1-binding protein 1, mitogen-activated protein kinase kinase kinase 7-interacting protein 1, transforming growth factor beta-activated kinase-binding protein 1
Species: human
Products:     TAB1

Top Publications

  1. Suzuki S, Singhirunnusorn P, Mori A, Yamaoka S, Kitajima I, Saiki I, et al. Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB. J Biol Chem. 2007;282:25177-81 pubmed
    ..ATF2, but not CREB, was a target for the TAK1-JNK pathway, and p38 negatively regulated TAK1 activity through TAB1 phosphorylation...
  2. Xia Z, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009;461:114-9 pubmed publisher
    ..These results indicate that unanchored polyubiquitin chains directly activate TAK1 and IKK, suggesting a new mechanism of protein kinase regulation. ..
  3. Scholz R, Sidler C, Thali R, Winssinger N, Cheung P, Neumann D. Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem. 2010;285:25753-66 pubmed publisher
    ..TAK1 autoactivation involves the interplay with TAK1-binding proteins (TAB), e.g. TAB1 and TAB2, and phosphorylation of several activation segment residues...
  4. Ninomiya Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature. 1999;398:252-6 pubmed
    ..Activated TAK1 phosphorylates NIK, which stimulates IKK-alpha activity. Our results indicate that TAK1 links TRAF6 to the NIK-IKK cascade in the IL-1 signalling pathway. ..
  5. Wang C, Deng L, Hong M, Akkaraju G, Inoue J, Chen Z. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature. 2001;412:346-51 pubmed
    ..Here we report the purification and identification of TRIKA2, which is composed of TAK1, TAB1 and TAB2, a protein kinase complex previously implicated in IKK activation through an unknown mechanism...
  6. Hasegawa M, Fujimoto Y, Lucas P, Nakano H, Fukase K, Nunez G, et al. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J. 2008;27:373-83 pubmed
    ..Thus, RICK polyubiquitination links TAK1 to IKK complexes, a critical step in Nod1/Nod2-mediated NF-kappaB activation. ..
  7. Kim S, Shim J, Chun E, Lee K. Reciprocal inhibition between the transforming growth factor-?-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein kinase kinase kinases and its suppression by TAK1-binding protein 2 (TAB2), an adapter . J Biol Chem. 2012;287:3381-91 pubmed publisher
    ..In this study we demonstrated that transforming growth factor-?-activated kinase 1 (TAK1)-TAK1-binding protein 1 (TAB1) complex negatively regulates ASK1-mediated signaling, and TAB2 reciprocally regulates TAK1-induced NF-?B and ..
  8. Ono K, Ohtomo T, Sato S, Sugamata Y, Suzuki M, Hisamoto N, et al. An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK. J Biol Chem. 2001;276:24396-400 pubmed
    ..TAK1 kinase activity is specifically activated by the TAK1-binding protein TAB1. The C-terminal 68-amino acid sequence of TAB1 (TAB1-C68) is sufficient for TAK1 interaction and activation...
  9. Ge B, Xiong X, Jing Q, Mosley J, Filose A, Bian D, et al. TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. J Biol Chem. 2003;278:2286-93 pubmed
    ..p38alpha autoactivation requires an interaction of p38alpha with TAB1 (transforming growth factor-beta-activated protein kinase 1-binding protein 1)...

More Information

Publications108 found, 100 shown here

  1. Walsh M, Kim G, Maurizio P, Molnar E, Choi Y. TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLoS ONE. 2008;3:e4064 pubmed publisher
    ..of TRAF6 is essential for formation and activation of a complex involving the kinase TAK1 and its adapters, TAB1 and TAB2...
  2. Kishimoto K, Matsumoto K, Ninomiya Tsuji J. TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J Biol Chem. 2000;275:7359-64 pubmed
    ..cytokines, including interleukin-1 (IL-1), or when ectopically expressed together with the TAK1-binding protein TAB1. However, this molecular mechanism of activation is not yet understood...
  3. Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch R, et al. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science. 2002;295:1291-4 pubmed
    ..Rather it depends on interaction of p38alpha with TAB1 [transforming growth factor-beta-activated protein kinase 1 (TAK1)-binding protein 1] leading to ..
  4. Zhou H, Zheng M, Chen J, Xie C, Kolatkar A, Zarubin T, et al. Determinants that control the specific interactions between TAB1 and p38alpha. Mol Cell Biol. 2006;26:3824-34 pubmed
    Previous studies have revealed that transforming growth factor-beta-activated protein kinase 1 (TAB1) interacts with p38alpha and induces p38alpha autophosphorylation...
  5. Bottero V, Kerur N, Sadagopan S, Patel K, Sharma Walia N, Chandran B. Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. J Virol. 2011;85:1980-93 pubmed publisher
    ..Finally, inhibition of TAK1 by celastrol inhibited vGPCR-induced NF-?B activation, indicating this natural compound could be used as a potential therapeutic drug against KSHV malignancies involving vGPCR...
  6. Jiang Z, Ninomiya Tsuji J, Qian Y, Matsumoto K, Li X. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol. 2002;22:7158-67 pubmed
    ..IRAK then brings TRAF6 to TAK1, TAB1, and TAB2, which are preassociated on the membrane before stimulation to form the membrane-associated complex II...
  7. Thiefes A, Wolf A, Doerrie A, Grassl G, Matsumoto K, Autenrieth I, et al. The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. EMBO Rep. 2006;7:838-44 pubmed
    ..inactive mutant YopP(C172A), also suppresses basal and interleukin-1-inducible activation of endogenous TAK1, TAB1 and TAB2...
  8. Mendoza H, Campbell D, Burness K, Hastie J, Ronkina N, Shim J, et al. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J. 2008;409:711-22 pubmed mechanism by which p38alpha MAPK down-regulates TAK1 and showed that p38alpha MAPK phosphorylates TAB1 at Ser(423) and Thr(431)...
  9. Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, et al. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 1996;272:1179-82 pubmed
    ..The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1...
  10. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. 2000;5:649-58 pubmed
    ..These results define TAB2 as an adaptor linking TAK1 and TRAF6 and as a mediator of TAK1 activation in the IL-1 signaling pathway. ..
  11. Conner S, Kular G, Peggie M, Shepherd S, Schuttelkopf A, Cohen P, et al. TAK1-binding protein 1 is a pseudophosphatase. Biochem J. 2006;399:427-34 pubmed
    b>TAB1 [TAK1 (transforming growth factor-beta-activated kinase 1)-binding protein 1] is one of the regulatory subunits of TAK1, a protein kinase that lies at the head of three pro-inflammatory kinase cascades...
  12. Kim S, Kwak J, Na H, Kim J, Ding Y, Choi M. Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. J Biol Chem. 2009;284:22285-96 pubmed publisher
    ..b>TAB1 does not interact with TGF-beta receptors, but TAB1 is indispensable for TGF-beta1-induced TAK1 activation...
  13. Sakurai H, Nishi A, Sato N, Mizukami J, Miyoshi H, Sugita T. TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways. Biochem Biophys Res Commun. 2002;297:1277-81 pubmed
    ..protein kinase kinase kinase (MAP3K) is activated by its specific activator, TAK1-binding protein 1 (TAB1)...
  14. Singhirunnusorn P, Suzuki S, Kawasaki N, Saiki I, Sakurai H. Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem. 2005;280:7359-68 pubmed
    ..RNA interference and overexpression experiments demonstrated that TAK1-binding protein TAB1 and TAB2 were involved in the phosphorylation of TAK1, but they regulated TAK1 phosphorylation differentially...
  15. Sakurai H, Miyoshi H, Toriumi W, Sugita T. Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. J Biol Chem. 1999;274:10641-8 pubmed
    ..of the mitogen-activated protein kinase kinase kinase family, together with its activator TAK1-binding protein 1 (TAB1) stimulates NF-kappaB activation. Here we investigated the molecular mechanism of TAK1-induced NF-kappaB activation...
  16. Sakurai H, Miyoshi H, Mizukami J, Sugita T. Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. FEBS Lett. 2000;474:141-5 pubmed
    ..Here, we characterized the molecular mechanisms of TAK1 activation by its specific activator TAB1. Autophosphorylation of two threonine residues in the activation loop of TAK1 was necessary for TAK1 activation...
  17. Cheung P, Nebreda A, Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem J. 2004;378:27-34 pubmed
    ..Our results indicate that two distinct TAK1 complexes are present in cells. One comprises TAK1 complexed with TAB1 and TAB2, and the other TAK1 complexed with TAB1 and TAB3...
  18. Mells G, Floyd J, Morley K, Cordell H, Franklin C, Shin S, et al. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat Genet. 2011;43:329-32 pubmed publisher
    ..New candidate genes include STAT4, DENND1B, CD80, IL7R, CXCR5, TNFRSF1A, CLEC16A and NFKB1. This study has considerably expanded our knowledge of the genetic architecture of PBC. ..
  19. Tokarev A, Suarez M, Kwan W, Fitzpatrick K, Singh R, Guatelli J. Stimulation of NF-?B activity by the HIV restriction factor BST2. J Virol. 2013;87:2046-57 pubmed publisher
    ..Consistent with a role for TAK1, BST2 coimmunoprecipitated with TAK1 and the TAK1-associated pseudophosphatase TAB1; these interactions required the YxY sequence in BST2...
  20. Wang S, Li M, Yin B, Li H, Xiao B, Lu K, et al. Shrimp TAB1 interacts with TAK1 and p38 and activates the host innate immune response to bacterial infection. Mol Immunol. 2017;88:10-19 pubmed publisher
    Mammalian TAB1 has been previously identified as transforming growth factor-? (TGF-?)-activated kinase 1 (TAK1) binding protein, which functions as the activator of TAK1 and p38...
  21. Gardner A, Fisher A, Richter C, Johnson G, Moisey E, Brodlie M, et al. The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. Am J Pathol. 2012;180:2293-308 pubmed publisher
    ..These data identify factors leading to and affected by accentuated and extended TAK1 phosphorylations potential novel therapeutic targets in inflammation-driven fibrotic diseases. ..
  22. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, et al. Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Genes Cells. 2001;6:1091-9 pubmed
    ..This study demonstrates that BMP2-induced neurite outgrowth in PC12 cells involves activation of the TAK1-p38 kinase pathway which is inhibited by Smad6 and Smad7. ..
  23. Du R, Zhou Y, Xia M, Lu M, Ding J, Hu G. α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes. J Neuroinflammation. 2018;15:258 pubmed publisher
    ..the association of β-arrestin2 with transforming growth factor-beta-activated kinase 1 (TAK1)-binding protein 1 (TAB1) and promoting TAK1-TAB1 interaction in astrocytes...
  24. Song P, Yang S, Hua H, Zhang H, Kong Q, Wang J, et al. The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells. J Biol Chem. 2019;294:5945-5955 pubmed publisher
    ..factor 6 (TRAF6) and transforming growth factor-β-activated kinase 1 (MAP3K7)-binding protein 1 (TAB1), which mediated the up-regulation of MCL-1 by GADD34...
  25. Emmerich C, Ordureau A, Strickson S, Arthur J, Pedrioli P, Komander D, et al. Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci U S A. 2013;110:15247-52 pubmed publisher
    ..Our study may help to resolve the debate about the relative importance of K63-pUb and M1-pUb chains in activating the canonical IKK complex. ..
  26. Huang H, Chiang C, Hung W, Hou M. Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer. Oncotarget. 2015;6:995-1007 pubmed
    ..We showed that activated TAK1 (as indicated by phospho-TAK1) and its binding protein TAB1 are strongly expressed in breast tumor tissues (77% and 74% respectively)...
  27. Chen Z, Zhang D, Li M, Wang B. Costunolide ameliorates lipoteichoic acid-induced acute lung injury via attenuating MAPK signaling pathway. Int Immunopharmacol. 2018;61:283-289 pubmed publisher
    ..Furthermore, costunolide treatment reduced the phosphorylation of TAK1 and inhibited the interaction of TAK1 with Tab1. In conclusion, we have demonstrated that costunolide protects against LTA-induced ALI via inhibiting TAK1-mediated ..
  28. Schimpl M, Schüttelkopf A, Borodkin V, van Aalten D. Human OGA binds substrates in a conserved peptide recognition groove. Biochem J. 2010;432:1-7 pubmed publisher
    ..amino acids lining this groove in human OGA were mutated and the activity on three different substrate proteins [TAB1 (transforming growth factor-β-activated protein kinase 1-binding protein 1), FoxO1 (forkhead box O1) and CREB (..
  29. Alpay M, Backman L, Cheng X, Dukel M, Kim W, Ai L, et al. Oxidative stress shapes breast cancer phenotype through chronic activation of ATM-dependent signaling. Breast Cancer Res Treat. 2015;151:75-87 pubmed publisher
    ..DNA damage-responsive signaling pathway as knockdown of two proteins involved in this signaling pathway, ERC1 and TAB1, results in loss of NF-κB basal activity...
  30. Yang C, Chiu L, Tan T. TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Cell Signal. 2016;28:145-51 pubmed publisher
    ..reported that DUSP14 negatively regulates T-cell activation and immune responses by interfering activation of TAB1-TAK1 complex. However, the molecular mechanism that regulates the phosphatase activity of DUSP14 remains unclear...
  31. Zhang L, Ding X, Cui J, Xu H, Chen J, Gong Y, et al. Cysteine methylation disrupts ubiquitin-chain sensing in NF-?B activation. Nature. 2011;481:204-8 pubmed publisher
    ..Given the prevalence of zinc-finger motifs and activation of cysteine thiol by zinc binding, methylation of zinc-finger cysteine might regulate other eukaryotic pathways in addition to NF-?B signalling. ..
  32. Hsiao H, Thatcher T, Levy E, Fulton R, Owens K, Phipps R, et al. Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. J Immunol. 2014;193:4980-7 pubmed publisher
    ..MAPK and NF-κB pathways, by inhibiting the formation of a poly(I:C)-induced signaling complex composed of TAK1, TAB1 (TAK1 binding protein), and TRAF6 (TNF receptor-associated factor 6)...
  33. Aashaq S, Batool A, Andrabi K. TAK1 mediates convergence of cellular signals for death and survival. Apoptosis. 2019;24:3-20 pubmed publisher
    ..TAK1 along with its binding partners TAB1, TAB2 and TAB3 displays a complex pattern of regulation that includes serious crosstalk with major signaling ..
  34. Ninomiya Tsuji J, Kajino T, Ono K, Ohtomo T, Matsumoto M, Shiina M, et al. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J Biol Chem. 2003;278:18485-90 pubmed
    ..Furthermore, in vivo 5Z-7-oxozeaenol was able to inhibit picryl chloride-induced ear swelling. Thus, 5Z-7-oxozeaenol blocks proinflammatory signaling by selectively inhibiting TAK1 MAPKKK. ..
  35. Liu Q, Zhang S, Chen G, Zhou H. E3 ubiquitin ligase Nedd4 inhibits AP-1 activity and TNF-α production through targeting p38α for polyubiquitination and subsequent degradation. Sci Rep. 2017;7:4521 pubmed publisher
    ..It has been reported that ubiquitination of Tak1 and TAB1 upstream of p38α can regulate p38α activation respectively. However, p38α ubiquitination is not yet clear...
  36. Tan B, Mu R, Chang Y, Wang Y, Wu M, Tu H, et al. RNF4 negatively regulates NF-κB signaling by down-regulating TAB2. FEBS Lett. 2015;589:2850-8 pubmed publisher
    ..We showed that RNF4 interacts with the TAK1-TAB2-TAB3 complex, but not TAB1. Further, we found that RNF4 specifically down-regulated TAB2 through a lysosomal pathway, and knockdown of RNF4 ..
  37. Culver C, Sundqvist A, Mudie S, Melvin A, Xirodimas D, Rocha S. Mechanism of hypoxia-induced NF-kappaB. Mol Cell Biol. 2010;30:4901-21 pubmed publisher
    ..IKK and the IKK kinase TAK1, like that for inflammatory inducers of NF-κB, but the TAK1-associated proteins TAB1 and TAB2 are not essential...
  38. Oho M, Nakano R, Nakayama R, Sakurai W, Miyamoto A, Masuhiro Y, et al. TIPE2 (Tumor Necrosis Factor ?-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal. J Biol Chem. 2016;291:22650-22660 pubmed
    ..TIPE2 interfered with the formation of the TAK1-TAB1-TAB2 complex and subsequently inhibited activation of TAK1 and its downstream molecules...
  39. Lee S, Choi Y, Cho N. Association between pathologic factors and ERG expression in prostate cancer: finding pivotal networking. J Cancer Res Clin Oncol. 2018;144:1665-1683 pubmed publisher
    ..Regulatory network analysis identified NOTCH1, MEF2C, STAT3, LCK, CACNA2D3, PCSK7, MEF2A, PDZD2, TAB1, and ASGR1 as pivotal genes...
  40. Cossu F, Milani M, Grassi S, Malvezzi F, Corti A, Bolognesi M, et al. NF023 binding to XIAP-BIR1: searching drugs for regulation of the NF-κB pathway. Proteins. 2015;83:612-20 pubmed publisher
    ..It has been shown that the XIAP-BIR1 (X-BIR1) domain is involved in the interaction with TAB1, an upstream adaptor for TAK1 kinase activation, which in turn couples with the NF-κB survival pathway...
  41. Qian Y, Commane M, Ninomiya Tsuji J, Matsumoto K, Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J Biol Chem. 2001;276:41661-7 pubmed
    ..The goal of this study was to understand how IRAK activates the intermediate proteins TRAF6, TAK1, TAB1, and TAB2...
  42. McGovern D, Jones M, Taylor K, Marciante K, Yan X, Dubinsky M, et al. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Hum Mol Genet. 2010;19:3468-76 pubmed publisher
    ..immunity (EXOC2), dendritic cell biology [CADM1 (IGSF4)], macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 (a physiological trait that regulates gastrointestinal mucosal expression of blood group A and B ..
  43. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H. BRAM1, a BMP receptor-associated molecule involved in BMP signalling. Genes Cells. 1998;3:257-64 pubmed
    ..BRAM1, a BMPR-IA associated molecule, was isolated using the yeast two-hybrid system, and found to associate specifically with BMPR-IA. BRAM1 may thus serve as an interacting protein in the BMP signal pathway. ..
  44. Tanno M, Bassi R, Gorog D, Saurin A, Jiang J, Heads R, et al. Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. Circ Res. 2003;93:254-61 pubmed
    ..04), suggesting an MKK-independent activation mechanism by ischemia. Hence, we examined p38-MAPK activation by TAB1-associated autophosphorylation...
  45. Chen H, Liu Y, Li D, Song J, Xia M. PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation. IUBMB Life. 2016;68:145-55 pubmed publisher
    ..Mechanistically, we revealed that TGF-β-activated kinase 1 (TAK1) and its adaptor protein TAK1 binding protein 1 (TAB1) played a dominant role in the regulatory effects of PGC-1β...
  46. Dong N, Tang X, Yuan X, Song H, Li J. [TAK1 promotes epithelial-mesenchymal transition of lens epithelial cells]. Zhonghua Yan Ke Za Zhi. 2016;52:278-84 pubmed publisher
    ..TAK1 was overexpressed in the HLE B-3 cell line by transfecting TAK1-pcDNA3 and TAK1-binding protein 1 (TAB1)-pcDNA3 plasmids...
  47. Zhu J, Li Q, He J, Liu G. Expression of TAK1/TAB1 expression in non-small cell lung carcinoma and adjacent normal tissues and their clinical significance. Int J Clin Exp Pathol. 2015;8:15801-7 pubmed
    ..of transforming growth factor beta-activated kinase 1 (TAK1) and its activation ligand, TAK1-binding protein 1 (TAB1), in non-small cell lung carcinoma (NSCLC) and adjacent normal tissues and to analyze the relevance between TAK1 ..
  48. Hirata Y, Takahashi M, Morishita T, Noguchi T, Matsuzawa A. Post-Translational Modifications of the TAK1-TAB Complex. Int J Mol Sci. 2017;18: pubmed publisher
    ..status of TAK1 is tightly regulated by forming a complex with its binding partners, TAK1-binding proteins (TAB1, TAB2, and TAB3)...
  49. Yin J, Li H, Meng C, Chen D, Chen Z, Wang Y, et al. Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/?-arrestin2/TGF-? activated kinase-1 binding protein-1 signaling pathway. Int J Biochem Cell Biol. 2016;75:11-22 pubmed publisher
    ..Fish omega-3 fatty acids as part of a daily diet may reduce EBI in an experimental rat model of SAH. ..
  50. Shuang T, Wang M, Zhou Y, Shi C, Wang D. NF-κB1, c-Rel, and ELK1 inhibit miR-134 expression leading to TAB1 upregulation in paclitaxel-resistant human ovarian cancer. Oncotarget. 2017;8:24853-24868 pubmed publisher
    ..Finally, TAB1 was identified as a functional target of miR-134, and the expression of TAB1 was increased by the transcription ..
  51. Liu X, Seh C, Cheung P. HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway. FEBS Lett. 2008;582:4023-31 pubmed publisher
    ..Our results suggest that Hsp90 is required for the folding and stability of TAK1 but is displaced and no longer required when TAK1 is complexed to TAK1-binding protein-1 (TAB1).
  52. Yang Y, Zhou C, Wang Y, Liu W, Liu C, Wang L, et al. The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition. EMBO Rep. 2017;18:205-216 pubmed publisher
    ..We show that five substrates could be degraded by RNF114-mediated ubiquitination, including TAB1. Furthermore, the degradation of TAB1 in mouse early embryos is required for MZT, most likely because it activates ..
  53. Yin D, Li W, Fu M, Chen L, Ma F, Jin P. Identification and characterization of a TAB1 gene involved in innate immunity of amphioxus (Branchiostoma belcheri). Gene. 2016;575:294-302 pubmed publisher
    ..TAK1-binding protein, TAB1, can specifically regulate the activation of TAK1...
  54. Luo Z, Ge M, Chen J, Geng Q, Tian M, Qiao Z, et al. HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection. PLoS Pathog. 2017;13:e1006585 pubmed publisher
    ..HRS subsequently enhances TLR7 complex formation in early- and late-endosome by interacting with TLR7 and TAB1. Moreover, HRS is involved in the regulation of the TLR7/NF-?B/p38 MAPK and the TLR7/NF-?B/IRF3 signaling pathways ..
  55. Arch R, Gedrich R, Thompson C. Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. Genes Dev. 1998;12:2821-30 pubmed
  56. Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G. An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. Biochem Biophys Res Commun. 2009;381:412-7 pubmed publisher
    ..Conversely, knockdown of FBXW5 resulted in the prolonged activation of TAK1 upon IL-1beta stimulation. These results suggest that FBXW5 negatively regulates TAK1 in the IL-1beta signaling pathway. ..
  57. Blonska M, Shambharkar P, Kobayashi M, Zhang D, Sakurai H, Su B, et al. TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem. 2005;280:43056-63 pubmed
    ..Although TAK1-MEKK3 interaction is not affected by overexpressed TAB1, TAB1 is required for TAK1 activation and subsequent MEKK3 phosphorylation...
  58. Lu Y, Zhang Y, Li L, Feng X, Ding S, Zheng W, et al. TAB1: a target of triptolide in macrophages. Chem Biol. 2014;21:246-56 pubmed publisher
    ..Here, we identify and explore TAB1 as the binding target of TP in macrophages by using a comprehensive approach combining pull-down assays, in vitro ..
  59. Bao S, Sun Q, Yao C. The interaction of TAK1 and TAB1 enhances LPS-induced cytokine release via modulating NF-?B activation (Larimichthys crocea). Fish Shellfish Immunol. 2018;74:450-458 pubmed publisher
    ..through the activation of nuclear factor-?B (NF-?B), which is specifically regulated by TAK1-binding protein 1 (TAB1)...
  60. Zhou W, Pal A, Hsu A, Gurol T, Zhu X, Wirbisky Hershberger S, et al. MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Cell Rep. 2018;22:1810-1823 pubmed publisher
    ..Cul1a/b, Traf6, and Tab1 are identified as direct targets of miR-223, and their levels rise in injured epithelium lacking miR-223...
  61. Grimsey N, Aguilar B, Smith T, Le P, Soohoo A, Puthenveedu M, et al. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015;210:1117-31 pubmed publisher
    ..TAB2 associated with TAB1, which induced p38 activation independent of MKK3 and MKK6...
  62. Zhang Y, O Keefe R, Jonason J. BMP-TAK1 (MAP3K7) Induces Adipocyte Differentiation Through PPARγ Signaling. J Cell Biochem. 2017;118:204-210 pubmed publisher
    ..required for PPARγ transactivation and promotes PPARγ transcriptional activity synergistically with TAK1 binding protein 1 (TAB1)...
  63. Rafie K, Raimi O, Ferenbach A, Borodkin V, Kapuria V, van Aalten D. Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats. Open Biol. 2017;7: pubmed publisher
    ..We describe a trapped complex of human OGT with the C-terminal domain of TAB1, a key innate immunity-signalling O-GlcNAc protein, revealing extensive interactions with the tetratricopeptide ..
  64. Isono T, Kim C, Ando Y, Sakurai H, Okada Y, Inoue H. Suppression of cell invasiveness by periostin via TAB1/TAK1. Int J Oncol. 2009;35:425-32 pubmed
    ..the molecular mechanism of this suppression by periostin, we searched for periostin-binding proteins and identified TAB1, which interacts with and activates TAK1, by mass analysis of proteins co-precipitated with periostin in 293T cells ..
  65. Moon G, Kim J, Min Y, Wi S, Shim J, Chun E, et al. Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling. Cell Signal. 2015;27:2524-33 pubmed publisher
    ..Collectively, the results demonstrate that PDK1 inhibits the formation of the TAK1-TAB2-TRAF6 complex and leads to the inhibition of TRAF6 ubiquitination, which negatively regulates the TLR4-mediated signaling for NF-κB activation. ..
  66. Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya Tsuji J. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood. 2012;120:3846-57 pubmed publisher
    ..TAK1 binding proteins 1 and 2 (TAB1 and TAB2) are activators of TAK1, but their roles in embryonic TAK1 signaling have not been determined...
  67. Guesmi F, Prasad S, Tyagi A, Landoulsi A. Antinflammatory and anticancer effects of terpenes from oily fractions of Teucruim alopecurus, blocker of I?B? kinase, through downregulation of NF-?B activation, potentiation of apoptosis and suppression of NF-?B-regulated gene expression. Biomed Pharmacother. 2017;95:1876-1885 pubmed publisher
    ..Finally, the activation of nuclear factor-?B induced by different plasmids (TNFR1, TRADD, TRAF2, NIK, TAK1/TAB1, and IKK?) was inhibited following treatment with TA-1...
  68. Thapa D, Nichols C, Bassi R, Martin E, Verma S, Conte M, et al. TAB1-Induced Autoactivation of p38α Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185. Mol Cell Biol. 2018;38: pubmed publisher
    ..second is by autophosphorylation of Thr180 and Tyr182 in cis, mediated by p38α binding the scaffold protein TAB1. The second mechanism occurs during myocardial ischemia, where it aggravates myocardial infarction...
  69. Yamaguchi K, Nagai S, Ninomiya Tsuji J, Nishita M, Tamai K, Irie K, et al. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 1999;18:179-87 pubmed
    ..TAK1, a member of the MAP kinase kinase kinase family, and its activator, TAB1, participate in the bone morphogenetic protein (BMP) signaling pathway involved in mesoderm induction and ..
  70. Lee R, Albanese C, Stenger R, Watanabe G, Inghirami G, Haines G, et al. pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-s. J Biol Chem. 1999;274:7341-50 pubmed
    ..Induction of cyclin D1 activity by pp60(v-src) may contribute to breast tumorigenesis through phosphorylation and inactivation of the retinoblastoma protein. ..
  71. Blanco S, Sanz Garcia M, Santos C, Lazo P. Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. PLoS ONE. 2008;3:e1660 pubmed publisher
    ..Furthermore, the effect might be more general and affect other signaling routes assembled on the JIP1 scaffold protein for which a model is proposed. ..
  72. Haas T, Emmerich C, Gerlach B, Schmukle A, Cordier S, Rieser E, et al. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009;36:831-44 pubmed publisher
    ..Finally, we demonstrate that sustained stability of the TNF-RSC requires LUBAC's enzymatic activity, thereby adding a third form of ubiquitin linkage to the triggering of TNF signaling by the TNF-RSC. ..
  73. Liu X, Li H, Zhong B, Blonska M, Gorjestani S, Yan M, et al. USP18 inhibits NF-?B and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. J Exp Med. 2013;210:1575-90 pubmed publisher
    ..immunity, regulates T cell activation and T helper 17 (Th17) cell differentiation by deubiquitinating the TAK1-TAB1 complex...
  74. Kang J, Chung K. The F-box protein FBXO7 positively regulates bone morphogenetic protein-mediated signaling through Lys-63-specific ubiquitination of neurotrophin receptor-interacting MAGE (NRAGE). Cell Mol Life Sci. 2015;72:181-95 pubmed publisher
    ..FBXO7 overexpression accelerates formation of NRAGE-TAK1-TAB1 complexes, whereas FBXO7 knockdown correspondingly decreases complex formation...
  75. Theivanthiran B, Kathania M, Zeng M, Anguiano E, Basrur V, Vandergriff T, et al. The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1. Sci Signal. 2015;8:ra22 pubmed publisher
    ..Itch bound directly to the TGF-β-activated kinase 1-binding protein 1 (Tab1) through a conserved PPXY motif and inhibited the activation of p38α...
  76. Edlund S, Bu S, Schuster N, Aspenstrom P, Heuchel R, Heldin N, et al. Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. Mol Biol Cell. 2003;14:529-44 pubmed
    ..Moreover, ectopically expressed Smad7 enhanced the coimmunoprecipitation of HA-MKK3 and Flag-p38, supporting the notion that Smad7 may act as a scaffolding protein and facilitate TAK1- and MKK3-mediated activation of p38. ..
  77. Ear T, Fortin C, Simard F, McDonald P. Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes. J Immunol. 2010;184:3897-906 pubmed publisher
  78. Coulthard L, Taylor J, Eyre S, Robinson J, Wilson A, Isaacs J, et al. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. Ann Rheum Dis. 2011;70:98-103 pubmed publisher
    ..Validation of these findings in independent cohorts is warranted. ..
  79. Burén S, Gomes A, Teijeiro A, Fawal M, Yilmaz M, Tummala K, et al. Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms. Cancer Cell. 2016;30:290-307 pubmed publisher
    ..Our work uncovers that URI-regulated OGT confers c-MYC-dependent survival functions in response to glucose fluctuations. ..
  80. Ishitani T, Kishida S, Hyodo Miura J, Ueno N, Yasuda J, Waterman M, et al. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003;23:131-9 pubmed
    ..These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling. ..
  81. Wolf A, Beuerlein K, Eckart C, Weiser H, Dickkopf B, Müller H, et al. Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1. PLoS ONE. 2011;6:e29256 pubmed publisher
    b>TAB1 was defined as a regulatory subunit of the protein kinase TAK1, which functions upstream in the pathways activated by interleukin (IL)-1, tumor necrosis factor (TNF), toll-like receptors (TLRs) and stressors...
  82. Ciechomska M, O Reilly S, Suwara M, Bogunia Kubik K, van Laar J. MiR-29a reduces TIMP-1 production by dermal fibroblasts via targeting TGF-β activated kinase 1 binding protein 1, implications for systemic sclerosis. PLoS ONE. 2014;9:e115596 pubmed publisher
    ..To investigate the role of miR-29a in regulation of TAB1-mediated TIMP-1 production in dermal fibroblasts in systemic sclerosis...
  83. Yang Z, Xian H, Hu J, Tian S, Qin Y, Wang R, et al. USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms. Sci Rep. 2015;5:12738 pubmed publisher
    ..Furthermore, USP18 interacted with TAK1-TAB1 complex and IKKα/β-NEMO complex, respectively...
  84. Jiang Z, Zamanian Daryoush M, Nie H, Silva A, Williams B, Li X. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR . J Biol Chem. 2003;278:16713-9 pubmed
    ..Kinase inactive mutants of TAK1 (TAK1DN) and PKR (PKRDN) inhibit poly(dI.dC)-induced TLR3-mediated NFkappaB activation, suggesting that both of these kinases play important roles in this pathway. ..
  85. Liu R, Lin Y, Jia R, Geng Y, Liang C, Tan J, et al. HIV-1 Vpr stimulates NF-?B and AP-1 signaling by activating TAK1. Retrovirology. 2014;11:45 pubmed publisher
    ..HIV-1 Vpr enhances the phosphorylation and polyubiquitination of TAK1, and as a result, activates NF-?B and AP-1 signaling pathways and stimulates HIV-1 LTR promoter...
  86. Mjomba F, Zheng Y, Liu H, Tang W, Hong Z, Wang F, et al. Homeobox Is Pivotal for OsWUS Controlling Tiller Development and Female Fertility in Rice. G3 (Bethesda). 2016;6:2013-21 pubmed publisher
    ..were caused by a mutation in OsWUS Compared with the two previously reported null allelic mutants of OsWUS (tab1-1 and moc3-1), which could produce partial N-terminal peptides of OsWUS, the srt1 protein contained a deletion of ..
  87. Singh R. Model Predicts That MKP1 and TAB1 Regulate p38? Nuclear Pulse and Its Basal Activity through Positive and Negative Feedback Loops in Response to IL-1. PLoS ONE. 2016;11:e0157572 pubmed publisher
    ..nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 through a positive feedback loop...
  88. Channavajhala P, Wu L, Cuozzo J, Hall J, Liu W, Lin L, et al. Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. J Biol Chem. 2003;278:47089-97 pubmed
    ..expression of hKSR-2, whereas transforming growth factor beta-activated kinase 1 (TAK1)/TAK1-binding protein 1 (TAB1)-induced interleukin-8 production is not affected by hKSR-2 co-expression...
  89. Neil J, Schiemann W. Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer Res. 2008;68:1462-70 pubmed publisher
    ..malignant counterparts, 4T1 cells, by inducing assembly of TGF-beta-activated kinase 1 (TAK1)-binding protein 1 (TAB1):I kappaB kinase beta (IKK beta) complexes, which led to the stimulation of a TAK1:IKK beta:p65 pathway...
  90. Shin M, Shinghirunnusorn P, Sugishima Y, Nishimura M, Suzuki S, Koizumi K, et al. Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1. Biochim Biophys Acta. 2009;1793:1156-64 pubmed publisher
    ..Ligand-induced activation of EGFR caused phosphorylation of the TAK1-binding proteins TAB1 and TAB2 in a TAK1-independent manner...
  91. Potter C, Cordell H, Barton A, Daly A, Hyrich K, Mann D, et al. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. Ann Rheum Dis. 2010;69:1315-20 pubmed publisher
    ..Validation of these findings in an independent cohort is now warranted. ..
  92. Prickett T, Ninomiya Tsuji J, Broglie P, Muratore Schroeder T, Shabanowitz J, Hunt D, et al. TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB. J Biol Chem. 2008;283:19245-54 pubmed publisher
    ..of four sites in TAK1, in a linker region between the kinase and TAB2/3 binding domains, and two sites in TAB1. Recombinant GST-TAB4 bound in an overlay assay directly to inactive TAK1 and activated TAK1 but not TAK1 ..