T bet


Gene Symbol: T bet
Description: T-box 21
Alias: T-PET, T-bet, TBET, TBLYM, T-box transcription factor TBX21, T-box expressed in T cells, T-box protein 21, T-cell-specific T-box transcription factor T-bet, transcription factor TBLYM
Species: human
Products:     T bet

Top Publications

  1. Yang M, Wang S, Wang S, Ma J, Xu X, Mao C, et al. Tat-mediated intracellular delivery of T-bet protein into THP-1 cells can induce Th1-type response. Immunol Invest. 2008;37:97-111 pubmed publisher
    ..The results demonstrated that the Tat/T-bet fusion protein can be efficiently transduced into antigen-presenting cells (APCs) like THP-1 cells and then regulated Th1/Th2 balance, which may act as a potential tool for gene therapy. ..
  2. Sun Q, Cheng D, Zhang M, He Q, Chen Z, Liu Z. Predominance of intraglomerular T-bet or GATA3 may determine mechanism of transplant rejection. J Am Soc Nephrol. 2011;22:246-52 pubmed publisher
    ..In summary, predominance of intraglomerular T-bet expression correlates with antibody-mediated rejection and resistance to steroid treatment. ..
  3. Johrens K, Dietel M, Anagnostopoulos I. Three different expression patterns of T-bet in angioimmunoblastic T-cell lymphoma. Leuk Lymphoma. 2012;53:152-5 pubmed publisher
  4. Ribeiro Dos Santos P, Turnbull E, Monteiro M, Legrand A, Conrod K, Baalwa J, et al. Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors. Blood. 2012;119:4928-38 pubmed publisher
  5. Hwang E, Szabo S, Schwartzberg P, Glimcher L. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005;307:430-3 pubmed
    ..These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell. ..
  6. Munthe Kaas M, Carlsen K, Håland G, Devulapalli C, Gervin K, Egeland T, et al. T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children. J Allergy Clin Immunol. 2008;121:51-6 pubmed
  7. Suzuki K, Kaminuma O, Hiroi T, Kitamura F, Miyatake S, Takaiwa F, et al. Downregulation of IL-13 gene transcription by T-bet in human T cells. Int Arch Allergy Immunol. 2008;146 Suppl 1:33-5 pubmed publisher
    ..IL-13 expression was downregulated by T-bet at the level of gene transcription, independently of the modulation of Th1/Th2 balance. T-bet is the potential key factor in the development of Th1/Th2-related diseases. ..
  8. Ylikoski E, Kinos R, Sirkkanen N, Pykäläinen M, Savolainen J, Laitinen L, et al. Association study of 15 novel single-nucleotide polymorphisms of the T-bet locus among Finnish asthma families. Clin Exp Allergy. 2004;34:1049-55 pubmed
    ..Our results provide a novel panel of SNPs in T-bet and will help determine whether the SNPs have a functional role in other T cell-mediated diseases. ..
  9. Tantisira K, Hwang E, Raby B, Silverman E, Lake S, Richter B, et al. TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A. 2004;101:18099-104 pubmed
    ..TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids. ..

More Information

Publications117 found, 100 shown here

  1. Raby B, Hwang E, Van Steen K, Tantisira K, Peng S, Litonjua A, et al. T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. Am J Respir Crit Care Med. 2006;173:64-70 pubmed
    ..Evidence of association of AHR with c.-7947, but not with other 3'UTR SNPs, was replicated in an independent cohort of adult males with AHR. These data suggest that T-bet variation contributes to airway responsiveness in asthma. ..
  2. Suttner K, Rosenstiel P, Depner M, Schedel M, Pinto L, Ruether A, et al. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. J Allergy Clin Immunol. 2009;123:1062-8, 1068.e1-8 pubmed publisher
    ..A risk score model indicates that TBX21 and HLX1 polymorphisms may have synergistic effects on asthma risk. ..
  3. Sun Q, Zhang M, Xie K, Li X, Zeng C, Zhou M, et al. Endothelial injury in transplant glomerulopathy is correlated with transcription factor T-bet expression. Kidney Int. 2012;82:321-9 pubmed publisher
    ..Since endothelial injury is a typical lesion that follows alloantibody reactivity, our results suggest that T-bet is involved in the pathogenesis of this glomerulopathy. ..
  4. Szabo S, Kim S, Costa G, Zhang X, Fathman C, Glimcher L. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000;100:655-69 pubmed
    ..Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs. ..
  5. Chung H, Kim L, Park B, Lee J, Park H, Choi B, et al. Association analysis of novel TBX21 variants with asthma phenotypes. Hum Mutat. 2003;22:257 pubmed
    ..TBX21 variation/haplotype information identified in this study will provide valuable information for future association studies of other immunological diseases. ..
  6. Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N, et al. Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Hum Genet. 2005;117:16-26 pubmed
  7. Jenner R, Townsend M, Jackson I, Sun K, Bouwman R, Young R, et al. The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A. 2009;106:17876-81 pubmed publisher
  8. Yang P, Qiu G, Su Z, Chen J, Wang S, Kong F, et al. The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers. Int J Immunogenet. 2010;37:111-5 pubmed publisher
    ..Our results indicated that a predominant Th2 phenotype was existence. T-bet gene mutations may be associated with Th2-dominated condition in gastric cancers. ..
  9. Hersperger A, Martin J, Shin L, Sheth P, Kovacs C, Cosma G, et al. Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression. Blood. 2011;117:3799-808 pubmed publisher
    ..These results suggest that T-bet may play an important role in driving effector function, and its modulation may lead to enhanced effector activity against HIV. ..
  10. Intlekofer A, Takemoto N, Wherry E, Longworth S, Northrup J, Palanivel V, et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol. 2005;6:1236-44 pubmed
    ..Therefore, these key transcription factors link the long-term renewal of memory CD8(+) T cells to their characteristic effector potency. ..
  11. Dai S, Zhuo M, Song L, Chen X, Yu Y, Zang G, et al. Lentiviral vector encoding ubiquitinated hepatitis B core antigen induces potent cellular immune responses and therapeutic immunity in HBV transgenic mice. Immunobiology. 2016;221:813-21 pubmed publisher
    ..The therapeutic vaccine LV-Ub-HBcAg could break immune tolerance, and induce potent HBcAg specific cellular immune responses and therapeutic effects in HBV transgenic mice. ..
  12. van Hamburg J, Tas S. Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis. J Autoimmun. 2018;87:69-81 pubmed publisher
    ..Understanding these mechanisms creates great potential to identify and select novel therapeutic targets which could improve current therapies or lead to development of new treatment strategies in RA. ..
  13. Han M, Ji X, Li G, Sang N. NO2 inhalation enhances asthma susceptibility in a rat model. Environ Sci Pollut Res Int. 2017;24:27843-27854 pubmed publisher
    ..These findings may provide a better understanding of mechanism of NO2-associated respiratory diseases. ..
  14. Rios R, Silva H, Carneiro N, Pires A, Carneiro T, Costa R, et al. Solanum paniculatum L. decreases levels of inflammatory cytokines by reducing NFKB, TBET and GATA3 gene expression in vitro. J Ethnopharmacol. 2017;209:32-40 pubmed publisher
    ..Gene expression of Th1-cell-specific Tbx21 transcription factor (TBET), zinc-finger transcription factor-3 (GATA3), and nuclear factor-κB (NFKB) in murine spleen cells were assessed ..
  15. Oikawa A, Shoji J, Inada N, Sawa M. Transconjunctival immunotherapy using cholera toxin B to treat experimental allergic conjunctivitis in a mouse model. Jpn J Ophthalmol. 2011;55:534-540 pubmed publisher
    ..Transconjunctival immunotherapy using CTB can be evaluated by histological examination of eosinophils and CD4-positive T cells, and a mucosal immunity-associated chemokine and a helper T-cell-17-associated chemokine as biomarkers. ..
  16. Ghonim M, Pyakurel K, Ju J, Rodriguez P, Lammi M, Davis C, et al. DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency. J Allergy Clin Immunol. 2015;135:425-40 pubmed publisher
    ..Our results suggest DNA-PK as a novel determinant of asthma and a potential target for the treatment of the disease. ..
  17. Liu Y, Ji H, Zhang Y, Shen X, Gao F, He X, et al. Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury. J Hepatol. 2015;62:563-72 pubmed publisher
    ..Negative regulation by recipient TIM-3+CD4+ cells provides evidence for cytoprotective functions of a discrete T cell subset, which should be spared when applying T cell-targeted immunosuppression in transplant recipients. ..
  18. Stepensky P, Rensing Ehl A, Gather R, Revel Vilk S, Fischer U, Nabhani S, et al. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. Blood. 2015;125:753-61 pubmed publisher
    ..Determination of senescent lymphocytes should be part of the diagnostic evaluation of children with refractory multilineage cytopenias. ..
  19. Haghmorad D, Amini A, Mahmoudi M, Rastin M, Hosseini M, Mahmoudi M. Pregnancy level of estrogen attenuates experimental autoimmune encephalomyelitis in both ovariectomized and pregnant C57BL/6 mice through expansion of Treg and Th2 cells. J Neuroimmunol. 2014;277:85-95 pubmed publisher
    ..Moreover, pregnancy and pregnancy level of estrogen decreased mRNA levels of T-bet and ROR-γt in the CNS. ..
  20. Zhang H, Fu J, Fan T, Zhang W, Wang Z, Wang L, et al. Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma. Chin Med. 2015;10:9 pubmed publisher
    ..0001). Histone deacetylation of Tm was observed during alleviation of allergen-induced eosinophilic airway inflammation in asthma by YGW. ..
  21. Nielsen M, Loynachan A, Jacobsen S, Stewart J, Reinemeyer C, Horohov D. Local and systemic inflammatory and immunologic reactions to cyathostomin larvicidal therapy in horses. Vet Immunol Immunopathol. 2015;168:203-10 pubmed publisher
    ..Transcription factors evaluated were FoxP3, GATA3 and tBet, and CD markers included CD163, CD3z, CD4, CD40, and CD8b...
  22. Qiao S, Ren H, Shi Y, Liu W. Allogeneic Compact Bone-Derived Mesenchymal Stem Cell Transplantation Attenuates the Severity of Idiopathic Pneumonia Syndrome in a Murine Bone Marrow Transplantation Model. Cell Physiol Biochem. 2016;40:1656-1669 pubmed publisher
    ..Allogeneic CB-MSCs effectively controlled the occurrence of IPS due to its profound immunomodulatory capacity. This may offer a novel prophylactic approach for IPS after allo-HSCT. ..
  23. Kim H, Song G, Park S, Jung M, Kim M, Kang H, et al. Association Between Expression Level of PD1 by Tumor-Infiltrating CD8+ T Cells and Features of Hepatocellular Carcinoma. Gastroenterology. 2018;155:1936-1950.e17 pubmed publisher
    ..PD1-high cells expressed TIM3 and LAG3, and low proportions of TCF1+, TBEThigh/eomesoderminlow, and CD127+...
  24. Bang M, Seo J, Seo J, Jo G, Jung S, Yu R, et al. Bacillus subtilis KCTC 11782BP-produced alginate oligosaccharide effectively suppresses asthma via T-helper cell type 2-related cytokines. PLoS ONE. 2015;10:e0117524 pubmed publisher
    ..Our findings suggest that AO has the potential to be an anti-asthmatic drug candidate, due to its modulation of Th1/Th2 cytokines, which contribute to the pathogenesis of asthma. ..
  25. Kozela E, Juknat A, Gao F, Kaushansky N, Coppola G, Vogel Z. Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. J Neuroinflammation. 2016;13:136 pubmed publisher
    ..These findings put forward mechanism by which CBD exerts its anti-inflammatory effects as well as explain the beneficial role of CBD in pathological memory T cells and in autoimmune diseases. ..
  26. Lazarevic V, Szabo S, Glimcher L. T-bet Runs INTERFERence. Immunity. 2017;46:968-970 pubmed publisher
    ..In this issue of Immunity, Iwata et al. (2017) report that the transcription factor T-bet acts as a selective repressor of the type I interferon (IFN) transcriptional program in response to IFN-? signaling. ..
  27. Ji N, Kovalovsky A, Fingerle Rowson G, Guentzel M, Forsthuber T. Macrophage migration inhibitory factor promotes resistance to glucocorticoid treatment in EAE. Neurol Neuroimmunol Neuroinflamm. 2015;2:e139 pubmed publisher
    ..Our data establish MIF as a key molecule in resistance of pathogenic CD4(+) T cells to GC treatment in EAE and as a potential target to enhance the effectiveness of steroid treatment in neuroinflammatory disorders. ..
  28. Van Helden M, Goossens S, Daussy C, Mathieu A, Faure F, Marçais A, et al. Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection. J Exp Med. 2015;212:2015-25 pubmed publisher
    ..Finally, this novel transcriptional cascade could also operate in human as T-bet and Zeb2 are similarly regulated in mouse and human NK cells. ..
  29. Dominguez C, Amezquita R, Guan T, Marshall H, Joshi N, Kleinstein S, et al. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. J Exp Med. 2015;212:2041-56 pubmed publisher
    ..Thus, the coordinated actions of T-bet and ZEB2 outline a novel genetic pathway that forces commitment of CTLs to terminal differentiation, thereby restricting their memory cell potential. ..
  30. Song X, He J, Xu H, Hu X, Wu X, Wu H, et al. The antiviral effects of acteoside and the underlying IFN-γ-inducing action. Food Funct. 2016;7:3017-30 pubmed publisher
    ..Given the role of IFN-γ in the immune system, further studies to clarify the role of acteoside in inducing IFN-γ and prevention of viral infection are needed. ..
  31. Hoffmann M, Pantazis N, Martin G, Hickling S, Hurst J, Meyerowitz J, et al. Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection. PLoS Pathog. 2016;12:e1005661 pubmed publisher
    ..New markers to identify exhausted T cells and novel interventions to reverse exhaustion may inform the development of novel immunotherapeutic approaches. ..
  32. Yao K, Peng C, Zhang Y, Zykova T, Lee M, Lee S, et al. RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth. Proc Natl Acad Sci U S A. 2017;114:12791-12796 pubmed publisher
    ..Overall, these results indicate that phosphorylation of T-bet is required for the inhibition of colon cancer metastasis and growth through a positive regulation of RSK2/T-bet/IFN? signaling. ..
  33. Sarkar K, Han S, Wen K, Ochs H, Dupré L, Seidman M, et al. R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome. J Allergy Clin Immunol. 2018;142:219-234 pubmed publisher
    ..The study proposes that cellular R-loop load could be used as a potential biomarker for monitoring symptom severity and prognostic outcome in the XLT-WAS clinical spectrum and could be targeted therapeutically. ..
  34. Kannan A, Sahu N, Mohanan S, Mohinta S, August A. IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells. J Allergy Clin Immunol. 2013;132:811-20.e1-5 pubmed publisher
  35. Buggert M, Tauriainen J, Yamamoto T, Frederiksen J, Ivarsson M, Michaelsson J, et al. T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection. PLoS Pathog. 2014;10:e1004251 pubmed publisher
    ..These results aid to explain the inability of HIV-specific CD8(+) T cells to control the viral replication post-ART cessation. ..
  36. Schreurs O, Karatsaidis A, Schenck K. Phenotypically non-suppressive cells predominate among FoxP3-positive cells in oral lichen planus. J Oral Pathol Med. 2016;45:766-773 pubmed publisher
    ..The findings emphasize that it is crucial to examine not only numbers but also functional phenotype of FoxP3+ CD4+ T cells in human tissues. ..
  37. Wang R, Xu A, Zhang X, Wu J, Freywald A, Xu J, et al. Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway. Cell Mol Immunol. 2017;14:529-545 pubmed publisher
    ..Therefore, this study should have a serious impact on the development of new therapeutic vaccines for human immunodeficiency virus (HIV-1) infection. ..
  38. Jiang S, Han S, Chen J, Li X, Che H. Inhibition effect of blunting Notch signaling on food allergy through improving TH1/TH2 balance in mice. Ann Allergy Asthma Immunol. 2017;118:94-102 pubmed publisher
    ..Notch signaling plays a key role in IgE-mediated food allergy. ..
  39. Wikberg M, Ling A, Li X, Oberg A, Edin S, Palmqvist R. Neutrophil infiltration is a favorable prognostic factor in early stages of colon cancer. Hum Pathol. 2017;68:193-202 pubmed publisher
    ..We further analyzed the prognostic impact of CD66b-positive cells in relation to other immune markers (NOS2, CD163, Tbet, FOXP3, and CD8) and found that neutrophil infiltration, even though strongly correlated to infiltration of other ..
  40. Buchan S, Fallatah M, Thirdborough S, Taraban V, Rogel A, Thomas L, et al. PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity. Clin Cancer Res. 2018;24:2383-2394 pubmed publisher
    ..i>Clin Cancer Res; 24(10); 2383-94. ©2018 AACR. ..
  41. Abromson Leeman S, Bronson R, Dorf M. Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles. J Neuroimmunol. 2009;215:10-24 pubmed publisher
    ..The former, bona fide Th1 cells, lack IL-23R expression under all conditions. In vivo, T-bet(+)/RORgammat(-) and T-bet(+)/RORgammat(+) clones induce EAE equally well...
  42. Weineisen M, Schottelius M, Simeček J, Baum R, Yildiz A, Beykan S, et al. 68Ga- and 177Lu-Labeled PSMA I&T: Optimization of a PSMA-Targeted Theranostic Concept and First Proof-of-Concept Human Studies. J Nucl Med. 2015;56:1169-76 pubmed publisher
    ..First-in-human (68)Ga-PSMA I&T PET imaging allowed high-contrast detection of bone lesions, lymph node, and liver metastases...
  43. Hou H, Cao R, Miao J, Sun Y, Liu X, Song X, et al. Fingolimod ameliorates the development of experimental autoimmune encephalomyelitis by inhibiting Akt-mTOR axis in mice. Int Immunopharmacol. 2016;30:171-178 pubmed publisher
    ..EAE exhibited an increased frequency of Th1 cells in the spleen, with concomitant increases in the mRNA levels of Tbet and Ifng and increased IFN-γ production by activated splenocytes; the frequency of Treg cells, as well as mRNA ..
  44. Kaufmann U, Shaw P, Kozhaya L, Subramanian R, Gaida K, Unutmaz D, et al. Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function. J Immunol. 2016;196:573-85 pubmed publisher
    ..Taken together, these findings support the conclusion that Th1 and Th17 cell function is particularly dependent on CRAC channels, which could be exploited as a therapeutic approach to T cell-mediated autoimmune diseases. ..
  45. Shashkova E, Trivedi J, Cline Smith A, Ferris C, Buchwald Z, Gibbs J, et al. Osteoclast-Primed Foxp3+ CD8 T Cells Induce T-bet, Eomesodermin, and IFN-? To Regulate Bone Resorption. J Immunol. 2016;197:726-35 pubmed publisher
    ..The results of this study demonstrate a novel link between NF-?B signaling and induction of IFN-? in TcREG and establish an important role for IFN-? in TcREG-mediated protection from bone loss. ..
  46. Roberts E, Carnathan D, Li H, Shaw G, Silvestri G, Betts M. Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques. PLoS Pathog. 2016;12:e1006135 pubmed publisher
  47. Zhou J, Kawai T, Yu Q. Pathogenic role of endogenous TNF-α in the development of Sjögren's-like sialadenitis and secretory dysfunction in non-obese diabetic mice. Lab Invest. 2017;97:458-467 pubmed publisher
    ..Collectively, these findings indicate that endogenous TNF-α has a pathogenic role in the development of SS in the NOD model of this disease. ..
  48. Beck B, Lee S, Kim D, Park J, Lee H, Kwon S, et al. A Lactococcus lactis BFE920 feed vaccine expressing a fusion protein composed of the OmpA and FlgD antigens from Edwardsiella tarda was significantly better at protecting olive flounder (Paralichthys olivaceus) from edwardsiellosis than single antige. Fish Shellfish Immunol. 2017;68:19-28 pubmed publisher
    ..lactis BFE920 expressing a fusion antigen composed of E. tarda OmpA and FlgD showed a strong protective effect against edwardsiellosis indicating this may be developed as an E. tarda feed vaccine. ..
  49. Kawabe T, Jankovic D, Kawabe S, Huang Y, Lee P, Yamane H, et al. Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function. Sci Immunol. 2017;2: pubmed publisher
  50. Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, et al. Regulatory CD4+ T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B. Circulation. 2018;: pubmed publisher
    ..This study identifies ApoB peptide 18 as the first Treg epitope in human and mouse atherosclerosis. ..
  51. Gocke A, Cravens P, Ben L, Hussain R, Northrop S, Racke M, et al. T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J Immunol. 2007;178:1341-8 pubmed
    ..We now show for the first time that suppression of T-bet ameliorates EAE by limiting the differentiation of autoreactive Th1 cells, as well as inhibiting pathogenic Th17 cells via regulation of IL-23R. ..
  52. Parnell G, Gatt P, Krupa M, Nickles D, McKay F, Schibeci S, et al. The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. Clin Immunol. 2014;151:16-24 pubmed publisher
    ..Expression was stable over time, but did not predict disease phenotype. Optimal response to therapy might be indicated by normalization of expression of these genes in blood. ..
  53. Nayar R, Schutten E, Jangalwe S, Durost P, Kenney L, Conley J, et al. IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection. PLoS ONE. 2015;10:e0144826 pubmed publisher
    ..These data highlight a critical role for IRF4 in regulating protective anti-viral CD8+ T cell responses by ensuring a balanced ratio of T-bet to Eomes, leading to the ultimate control of this chronic viral infection. ..
  54. Lin Y, Zhou X, Guo W, Li Q, Pan X, Bao Y, et al. RhIL-11 treatment normalized Th1/Th2 and T-bet/GATA-3 imbalance in in human immune thrombocytopenic purpura (ITP). Int Immunopharmacol. 2016;38:40-4 pubmed publisher
    ..Thus our study suggested rhIL-11 was effective with tolerable adverse effects in ITP. The treatment strategy warrants further clinical investigation. ..
  55. Kiniry B, Ganesh A, Critchfield J, Hunt P, Hecht F, Somsouk M, et al. Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. Mucosal Immunol. 2017;10:1008-1020 pubmed publisher
    ..Further elucidation of rectal immune responses to HIV will inform the development of vaccines and immunotherapies targeted to mucosal tissues. ..
  56. Xie J, Wang H. Semaphorin 7A as a potential immune regulator and promising therapeutic target in rheumatoid arthritis. Arthritis Res Ther. 2017;19:10 pubmed publisher
    ..These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of RA, suggesting its therapeutic potential in the treatment of RA. ..
  57. Fang M, Xia S, Bi J, Wigstrom T, Valenzano L, Wang J, et al. A cyanine-based fluorescent cassette with aggregation-induced emission for sensitive detection of pH changes in live cells. Chem Commun (Camb). 2018;54:1133-1136 pubmed publisher
    ..fluorescent cassette with a large pseudo-Stokes shift was designed and prepared to sensitively image pH changes in live cells via through-bond energy transfer (TBET) from a tetraphenylethene (TPE) donor to a cyanine acceptor.
  58. Koutoulaki A, Langley M, Sloan A, Aeschlimann D, Wei X. TNFalpha and TGF-beta1 influence IL-18-induced IFNgamma production through regulation of IL-18 receptor and T-bet expression. Cytokine. 2010;49:177-84 pubmed publisher
  59. Singer C. T-bet is induced by interferon-? to mediate chemokine secretion and migration in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2011;300:L633-41 pubmed publisher
    ..These results are the first to identify T-bet expression and activity in a structural cell of the lung and may provide new insights into therapeutic targets for inflammatory airway disease. ..
  60. Victorino F, Sojka D, Brodsky K, McNamee E, Masterson J, Homann D, et al. Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody. J Immunol. 2015;195:4973-85 pubmed publisher
    ..In total, these data demonstrate that trNK cells play a key role in modulating local responses to ischemic tissue injury in the kidney and potentially other organs. ..
  61. Yu S, Jia L, Zhang Y, Zhong J, Yang B, Wu C. IL-12 induced the generation of IL-21- and IFN-γ-co-expressing poly-functional CD4+ T cells from human naive CD4+ T cells. Cell Cycle. 2015;14:3362-72 pubmed publisher
    ..Poly-functional CD4(+) T cells were contributed to generation and progress of varies diseases and our studies provide basic theoretics for the designs of vaccine and therapies of diseases. ..
  62. Monteleone I, Marafini I, Dinallo V, Di Fusco D, Troncone E, Zorzi F, et al. Sodium chloride-enriched Diet Enhanced Inflammatory Cytokine Production and Exacerbated Experimental Colitis in Mice. J Crohns Colitis. 2017;11:237-245 pubmed publisher
    ..Our data indicated that exposure of intestinal mononuclear cells to a high-NaCl diet enhanced effector cytokine production and contributed to the exacerbation of experimental colitis in mice. ..
  63. Park E, Song J, Kim M, Park S, Kim T. Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4+ T cells through the modulation of mitogen-activated protein kinases. Int Immunopharmacol. 2016;40:508-516 pubmed publisher
    ..Taken together, these results suggest that costunolide inhibits the differentiation of CD4+ T cells by suppressing ERK and p38 activities and can be an effective therapeutic agent for T cell-mediated immune diseases. ..
  64. Singh D, Tanwar H, Jayashankar B, Sharma J, Murthy S, Chanda S, et al. Quercetin exhibits adjuvant activity by enhancing Th2 immune response in ovalbumin immunized mice. Biomed Pharmacother. 2017;90:354-360 pubmed publisher
    ..Quercetin also did not cause any hemolysis in human RBCs. Overall, our findings strongly demonstrate the novel in vivo immunostimulatory and adjuvant potentials of quercetin. ..
  65. Elahi A, Sabui S, Narasappa N, Agrawal S, Lambrecht N, Agrawal A, et al. Biotin Deficiency Induces Th1- and Th17-Mediated Proinflammatory Responses in Human CD4+ T Lymphocytes via Activation of the mTOR Signaling Pathway. J Immunol. 2018;200:2563-2570 pubmed publisher
    ..In summary, these results demonstrate that biotin deficiency enhances the inflammatory responses in CD4+ T cells, which may contribute to inflammation associated with biotin deficiency. ..
  66. Zissler U, Chaker A, Effner R, Ulrich M, Guerth F, Piontek G, et al. Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways. Mucosal Immunol. 2016;9:917-26 pubmed publisher
  67. Zhang W, Yang S. Cloning and characterization of a new member of the T-box gene family. Genomics. 2000;70:41-8 pubmed
    ..TBX21 expression was detected in peripheral blood lymphocytes, spleen, lung, and natural killer cells. ..
  68. Leng R, Pan H, Liu J, Yang X, Zhang C, Tao S, et al. Evidence for genetic association of TBX21 and IFNG with systemic lupus erythematosus in a Chinese Han population. Sci Rep. 2016;6:22081 pubmed publisher
    ..60, P = 0.003). In addition, we also identified a significant genetic interaction between rs2069705 and rs4794067 in Anhui Chinese population. Our study suggests that IFNG and IFNG-TBX21 interaction are involved in SLE susceptibility. ..
  69. Sen D, Kaminski J, Barnitz R, Kurachi M, Gerdemann U, Yates K, et al. The epigenetic landscape of T cell exhaustion. Science. 2016;354:1165-1169 pubmed
    ..Functional enhancer maps may offer targets for genome editing that alter gene expression preferentially in exhausted CD8+ T cells. ..
  70. Portugal S, Obeng Adjei N, Moir S, Crompton P, Pierce S. Atypical memory B cells in human chronic infectious diseases: An interim report. Cell Immunol. 2017;321:18-25 pubmed publisher
    ..We also comment on the possible relationship of human aMBCs and T-bet+, CD11c+ age/autoimmune-associated B cells, also a topic of this review volume. ..
  71. Zens K, Chen J, Guyer R, Wu F, Cvetkovski F, Miron M, et al. Reduced generation of lung tissue-resident memory T cells during infancy. J Exp Med. 2017;214:2915-2932 pubmed publisher
    ..Our findings reveal that infant T cells are intrinsically programmed for short-term responses, and targeting key regulators could promote long-term, tissue-targeted protection at this critical life stage. ..
  72. Iwata S, Mikami Y, Sun H, Brooks S, Jankovic D, Hirahara K, et al. The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells. Immunity. 2017;46:983-991.e4 pubmed publisher
    ..Thus, in addition to promoting Th1 effector commitment, T-bet acts as a repressor in differentiated Th1 cells to prevent abberant autocrine type I IFN and downstream signaling. ..
  73. Billerbeck E, Labitt R, Vega K, Frias Staheli N, Dorner M, Xiao J, et al. Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA-3(+) and GATA-3(+) T-bet(+) subsets in humanized mice. Immunology. 2014;143:202-18 pubmed publisher
    ..In conclusion, our study shows the capacity of human CD4(+) and CD8(+) T cells for stable co-expression of GATA-3 and T-bet in humanized mice and reveals a critical role for IL-12 in regulating this phenotype. ..
  74. Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, et al. A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet. Nat Immunol. 2016;17:422-32 pubmed publisher
  75. Mohr E, Cunningham A, Toellner K, Bobat S, Coughlan R, Bird R, et al. IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine. Proc Natl Acad Sci U S A. 2010;107:17292-7 pubmed publisher
    ..Thus, T-bet dependence identifies distinct transcriptional pathways in B cells that regulate IFN-?-induced switching to different IgG isotypes...
  76. Wang Q, Ren S, Dong W, Fang J. [Effects of transcription factor T-bet, GATA-3, FoxP3 and CD4(+)CD25(+)regulatory T cells in pathogenesis of child Hench-Schonlein purpura]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012;20:133-6 pubmed
  77. Simonetta F, Pradier A, Bosshard C, Masouridi Levrat S, Chalandon Y, Roosnek E. NK Cell Functional Impairment after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Reduced Levels of T-bet and Eomesodermin. J Immunol. 2015;195:4712-20 pubmed publisher
    ..Collectively, our results provide a possible molecular explanation for the previously reported functional exhaustion of NK cells after allogeneic HSCT and suggest an impact of the NK transcriptional machinery status on HSCT outcome. ..
  78. Lau M, Keith P, Costello M, Bradbury L, Hollis K, Thomas R, et al. Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis. Ann Rheum Dis. 2017;76:261-269 pubmed publisher
    ..This indicates that T-bet is a major component of inflammatory pathways of spondyloarthropathy in humans and mice. ..
  79. Lino C, Barros Martins J, Oberdörfer L, Walzer T, Prinz I. Eomes expression reports the progressive differentiation of IFN-?-producing Th1-like ?? T cells. Eur J Immunol. 2017;47:970-981 pubmed publisher
    ..Together, this study highlights Eomes as a marker for the differentiation of Th1-like effector ?? T cells. ..
  80. Liu Z, Wu L, Zhu J, Zhu X, Zhu J, Liu J, et al. Interleukin-27 signalling induces stem cell antigen-1 expression in T lymphocytes in vivo. Immunology. 2017;152:638-647 pubmed publisher
    ..Direct expansion of Sca-1+  CD62L+  CD44- T memory stem cells may explain why IL-27 enhances T-cell memory. ..
  81. Harashima A, Matsuo Y, Drexler H, Okochi A, Motoda R, Tanimoto M, et al. Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet. Leuk Res. 2005;29:841-8 pubmed
    ..No significant changes were observed for the other 12 TFs. The present report could provide useful information in the study of the role of TFs on normal and malignant human BCPs. ..
  82. Jha S, Chakraborty N, Singh P, Mukherji B, Dorsky D. Knockdown of T-bet expression in Mart-127-35 -specific T-cell-receptor-engineered human CD4(+)  CD25(-) and CD8(+) T cells attenuates effector function. Immunology. 2015;145:124-35 pubmed publisher
  83. Liao D, Hou S, Zhang J, Fang J, Liu Y, Bai L, et al. Copy number variants and genetic polymorphisms in TBX21, GATA3, Rorc, Foxp3 and susceptibility to Behcet's disease and Vogt-Koyanagi-Harada syndrome. Sci Rep. 2015;5:9511 pubmed publisher
    ..Our study showed that high CNVs of Rorc and low CNVs of Foxp3 confer risk for BD but not for VKH syndrome. The tested 25 SNPs in TBX21, GATA3, Rorc and Foxp3 did not associate with BD and VKH syndrome. ..
  84. Sasaki Y, Ihara K, Matsuura N, Kohno H, Nagafuchi S, Kuromaru R, et al. Identification of a novel type 1 diabetes susceptibility gene, T-bet. Hum Genet. 2004;115:177-84 pubmed
  85. Höhler T, Reuss E, Adams P, Bartsch B, Weigmann B, Wörns M, et al. A genetic basis for IFN-gamma production and T-bet expression in humans. J Immunol. 2005;175:5457-62 pubmed
    ..This concept is highlighted by the recent finding that inactivation of the T-bet gene in mice results in development of clinical hallmark features of asthma. ..
  86. Guo Y, Xu Y, Xu Y. [Expression of T-bet, GATA-3 and FOXP3 mRNA in asthmatic peripheral blood mononuclear cells stimulated by Dermatophagoides farinae antigen]. Zhonghua Jie He He Hu Xi Za Zhi. 2007;30:112-5 pubmed
    ..46, P < 0.05, r = -0.62, P < 0.01 respectively). There are a predominant expression of GATA-3 and T-bet, but a decreased expression of FOXP3 in Df-stimulated PBMCs from patients with asthma. ..
  87. Lohneis P, Wienert S, Klauschen F, Ullrich A, Anagnostopoulos I, Johrens K. Marginal zone lymphomas with monocytoid morphology express T-bet and are associated with a low number of T cells in extranodal locations. Leuk Lymphoma. 2014;55:143-8 pubmed publisher
    ..In analogy to reactive monocytoid B lymphocytes, we also found a significantly lower relative amount of intratumoral T lymphocytes in extranodal MZL with monocytoid morphology. ..
  88. Valenzuela Muñoz V, Boltaña S, Gallardo Escárate C. Comparative immunity of Salmo salar and Oncorhynchus kisutch during infestation with the sea louse Caligus rogercresseyi: An enrichment transcriptome analysis. Fish Shellfish Immunol. 2016;59:276-287 pubmed publisher
    ..Additionally, putative roles of TLRs in salmonids against sea lice were evidenced. This study is the first comparative transcriptome analysis that reveals species-specific immune responses in salmons infected with C. rogercresseyi. ..
  89. Theruvath A, Ilivitzki A, Muehe A, Theruvath J, Gulaka P, Kim C, et al. A PET/MR Imaging Approach for the Integrated Assessment of Chemotherapy-induced Brain, Heart, and Bone Injuries in Pediatric Cancer Survivors: A Pilot Study. Radiology. 2017;285:971-979 pubmed publisher
    ..10 pediatric cancer survivors who completed chemotherapy underwent imaging of the brain, heart, and bone with a 3-T PET/MR imager...
  90. Eisenhut F, Heim L, Trump S, Mittler S, Sopel N, Andreev K, et al. FAM13A is associated with non-small cell lung cancer (NSCLC) progression and controls tumor cell proliferation and survival. Oncoimmunology. 2017;6:e1256526 pubmed publisher
    ..Consistently, FAM13A RhoGAP was found to be associated with T cell effector molecules like HIF1? and Tbet and was downregulated in immunosuppressive CD4+CD25+Foxp3+CTLA4+ T ..
  91. Wang H, Li J, Han Q, Yang F, Xiao Y, Xiao M, et al. IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis. Int J Med Sci. 2017;14:977-983 pubmed publisher
    ..b>Conclusions: The biological effects of Tem could significantly affect IPA infection host immune regulation, which depended on the activation of mTOR signaling pathway by IL-12. ..
  92. Lee S, Bae C, Seo J, Cho S, Bae M, Oh D, et al. Mycoleptodonoides aitchisonii suppresses asthma via Th2 and Th1 cell regulation in an ovalbumin?induced asthma mouse model. Mol Med Rep. 2017;: pubmed publisher
    ..In addition, M. atichisonii significantly inhibited the expression of IL?5, IL?13 and IL?6. The authors concluded that M. atichisonii may be a promising drug candidate against asthma...