SYT1

Summary

Gene Symbol: SYT1
Description: synaptotagmin I
Alias: P65, SVP65, SYT, synaptotagmin 1, sytI
Species: human

Top Publications

  1. pmc The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export
    Igor Prudovsky
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    J Cell Biol 158:201-8. 2002
  2. ncbi Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Republic of China
    J Biol Chem 279:26143-8. 2004
  3. ncbi Chromatin-dependent E1A activity modulates NF-kappaB RelA-mediated repression of glucocorticoid receptor-dependent transcription
    Barbara A Burkhart
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:6349-58. 2005
  4. ncbi Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction
    Darren M Hutt
    Ottawa Health Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 280:20197-203. 2005
  5. ncbi The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis
    Yanhua Peng
    Department of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, Florida 33601, USA
    J Gastrointest Surg 10:837-47. 2006
  6. pmc NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1)
    Karuppanan Muthusamy Kathir
    Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA
    Biochim Biophys Acta 1798:297-302. 2010
  7. pmc The c2 domains of human synaptotagmin 1 have distinct mechanical properties
    Kerry L Fuson
    Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biophys J 96:1083-90. 2009
  8. ncbi Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling
    J Z Zhang
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 78:751-60. 1994
  9. ncbi Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis
    Xiaodong Zhang
    Department of Biochemistry, University of Wisconsin, Madison 53706, USA
    Neuron 34:599-611. 2002
  10. ncbi S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro
    C Mouta Carreira
    Center for Molecular Medicine, Maine Medical Center Research Institute, South Portland, Maine 04106, USA
    J Biol Chem 273:22224-31. 1998

Detail Information

Publications341 found, 100 shown here

  1. pmc The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export
    Igor Prudovsky
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    J Cell Biol 158:201-8. 2002
    ..cytosolic pattern to a locale near the inner surface of the plasma membrane where it colocalized with S100A13 and Syt1. In addition, coexpression of dominant-negative mutant forms of S100A13 and Syt1, which both repress the release of ..
  2. ncbi Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Republic of China
    J Biol Chem 279:26143-8. 2004
    ..directly interacts with and activates NF-kappaB led us to examine the phosphorylation status of NF-kappaB p65. Coincident with activation of NF-kappaB, cisplatin induced Ser phosphorylation but decreased Thr phosphorylation ..
  3. ncbi Chromatin-dependent E1A activity modulates NF-kappaB RelA-mediated repression of glucocorticoid receptor-dependent transcription
    Barbara A Burkhart
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:6349-58. 2005
    ..in the repression of glucocorticoid-dependent transcription from the murine mammary tumor virus (MMTV) promoter by p65 and E1A was investigated by using chromatin and transiently transfected reporters...
  4. ncbi Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction
    Darren M Hutt
    Ottawa Health Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 280:20197-203. 2005
    ..and VAMP2, mediates vesicle fusion, whereas calcium regulation is thought to be accomplished by the synaptotagmin (Syt) family, some of which exhibit calcium-dependent binding to syntaxin and SNAP-25...
  5. ncbi The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis
    Yanhua Peng
    Department of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, Florida 33601, USA
    J Gastrointest Surg 10:837-47. 2006
    ..The aim of our study was to determine the role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis...
  6. pmc NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1)
    Karuppanan Muthusamy Kathir
    Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA
    Biochim Biophys Acta 1798:297-302. 2010
    ..as a multiprotein complex consisting of hFGF-1, S100A13 (a calcium binding protein), and p40 synaptotagmin (Syt1)...
  7. pmc The c2 domains of human synaptotagmin 1 have distinct mechanical properties
    Kerry L Fuson
    Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biophys J 96:1083-90. 2009
    b>Synaptotagmin 1 (Syt1) is the Ca(+2) receptor for fast, synchronous vesicle fusion in neurons. Because membrane fusion is an inherently mechanical, force-driven event, Syt1 must be able to adapt to the energetics of the fusion apparatus...
  8. ncbi Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling
    J Z Zhang
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 78:751-60. 1994
    ..Thus, synaptotagmin I may be a multifunctional protein with a function in endocytosis in addition to the previously proposed role in exocytosis...
  9. ncbi Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis
    Xiaodong Zhang
    Department of Biochemistry, University of Wisconsin, Madison 53706, USA
    Neuron 34:599-611. 2002
    ..These results indicate that the Ca2+-dependent interaction of synaptotagmin with SNAP-25 is essential for the Ca2+-dependent triggering of membrane fusion...
  10. ncbi S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro
    C Mouta Carreira
    Center for Molecular Medicine, Maine Medical Center Research Institute, South Portland, Maine 04106, USA
    J Biol Chem 273:22224-31. 1998
    ..as a stress-induced pathway in which FGF-1 is released as a latent homodimer with the p40 extravesicular domain of p65 synaptotagmin (Syn)-1...
  11. ncbi SV2B regulates synaptotagmin 1 by direct interaction
    Diana R Lazzell
    WM Keck Center for Learning and Memory, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:52124-31. 2004
    ..Previous studies found that SV2A, but not SV2B, can interact with the cytoplasmic domain of synaptotagmin 1, a Ca2+ sensor for synaptic vesicle exocytosis...
  12. ncbi Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin
    A Betz
    Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, Hermann Rein Strasse 3, D 37075 Gottingen, Federal Republic of Germany
    J Biol Chem 272:2520-6. 1997
    ..It is possible that the phenotype of unc-13 and unc-18 mutations is caused by the inability of the respective mutated gene products to bind to syntaxin...
  13. ncbi Synaptotagmin I functions as a calcium regulator of release probability
    R Fernandez-Chacon
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas 75390 9111, USA
    Nature 410:41-9. 2001
    ..Therefore, Ca2+ binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse...
  14. ncbi Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association
    Kerry L Fuson
    Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biochemistry 46:13041-8. 2007
    Release of neurotransmitter from synaptic vesicles requires the Ca2+/phospholipid-binding protein synaptotagmin 1. There is considerable evidence that cooperation between the tandem C2 domains of synaptotagmin is a requirement of ..
  15. ncbi Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins
    M Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    Biochem Biophys Res Commun 281:1226-33. 2001
    Synaptotagmins (Syt), rabphilin-3A, and Doc2 belong to a family of carboxyl terminal type (C-type) tandem C2 proteins and are thought to be involved in vesicular trafficking...
  16. ncbi Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress
    M Landriscina
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 276:25549-57. 2001
    ..protein and Cu2+ is known to induce its dimerization, we evaluated the capacity of recombinant FGF1, p40 Syt1, and S100A13 to interact in a cell-free system and the role of Cu2+ in this interaction...
  17. pmc Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
    K Ito
    Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    Mol Cell Biol 20:6891-903. 2000
    ..as a direct inhibitor of CREB binding protein (CBP)-associated HAT activity and also by recruiting HDAC2 to the p65-CBP HAT complex...
  18. ncbi p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex
    K Ito
    Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse St, London SW3 6LY, United Kingdom
    J Biol Chem 276:30208-15. 2001
    ..and granulocyte-macrophage colony-stimulating factor expression through a combination of direct inhibition of p65-associated histone acetyltransferase (HAT) activity and by recruiting histone deacetylase 2 (HDAC2) to the p65-HAT ..
  19. ncbi Effect of a synthetic lipid immunomodulator on the regulation of the transcription factor NF-kappaB
    S Pollet
    , La Tronche, France
    Immunopharmacol Immunotoxicol 22:653-69. 2000
    ..Antibodies to various NF-kappaB proteins supershifted p50, p65 and to a lesser extent c-rel...
  20. ncbi Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats
    Wei Guo Dong
    Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 9:2533-8. 2003
    ..To investigate the ameliorative effects of sodium ferulate (SF) on acetic acid-induced colitis and their mechanisms in rats...
  21. ncbi [Detection of cytomegalovirus (CMV) antigen for rapid diagnosis and monitoring of CMV diseases in AIDS]
    H Hanabusa
    Department of Pediatrics, Ogikubo Hospital
    Kansenshogaku Zasshi 68:1105-12. 1994
    ..leukocyte (CMV antigenemia), as it was determined with a monoclonal antibody against a lower matrix protein (p65); infectious CMV detected by shell vial method; CMV DNA detected by PCR; anti-CMV antibody titer; and histological ..
  22. ncbi [Research on the influence of diammonium glycyrrhizinate on the expression of NF-kappaB and neuron apoptosis after spinal cord ischemia-reperfusion injury in rats]
    Bingrui Liu
    Department of Clinical Medicine, Second Affiliated Hospital, Ningxia Medical University, Yinchuan Ningxia 750004, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:1466-9. 2008
    ..To investigate the influence of diammonium glycyrrhizinate (DG) on the expression of NF-kappaB and neuron apoptosis after spinal cord ischemia-reperfusion injury in rats...
  23. pmc I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding
    P A Ganchi
    Gladstone Institute of Virology and Immunology, University of California, San Francisco
    Mol Biol Cell 3:1339-52. 1992
    ..nuclear form of the NF-kappa B transcription factor complex is composed of two DNA binding subunits, NF-kappa B p65 and NF-kappa B p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product...
  24. doi HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity
    Inbal Azran-Shaish
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, 84105, Israel
    J Mol Med (Berl) 86:799-814. 2008
    ..induce their dissociation from inhibitors of kappaB (IkappaB) and subsequent translocation to the nucleus where p65 links to the cyclic adenosine monophosphate response element binding protein (CBP)-p300 and P/CAF coactivators that ..
  25. ncbi [Effects of antisense oligonucleotide to nuclear factor-kappaB on the development of bleomycin-induced pulmonary fibrosis and IL-4 expression therein: experiment with mice]
    Xiao Ye Zhang
    Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China
    Zhonghua Yi Xue Za Zhi 87:195-9. 2007
    ....
  26. ncbi [The function of nuclear factor-erythroid 2-related factor 2 and its association with I-kappa B kinases alpha/beta in a rat model of chronic obstructive pulmonary disease.]
    Xiu Ying Li
    Respiratory Department of Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:935-9. 2009
    ..To study the expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the bronchial and lung tissues of chronic obstructive pulmonary disease (COPD) rat models and its association with I-kappa B kinases (IKKs)...
  27. ncbi [Evaluation of direct immunoperoxidase technique using F(ab')2 fractions of anti-cytomegalovirus human monoclonal antibody for enumeration of cytomegalovirus antigen-positive leukocytes]
    T Minematsu
    Department of Microbiology, Miyazaki Medical College
    Kansenshogaku Zasshi 68:1278-84. 1994
    Direct immunoperoxidase technique using human monoclonal antibody (C7) against a p65 antigen of cytomegalovirus (CMV) has been utilized to detect CMV antigen-positive leukocytes in the peripheral blood (CMV antigenemia)...
  28. ncbi [Effects of hydrogen sulfide on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow: experiment with rats]
    Hong fang Jin
    Department of Pediatrics, Peking University First Hospital, Key Lab of Molecular Cardiovascular Medicine, Ministry of Education, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 88:2235-9. 2008
    ..To investigate the effects of hydrogen sulfide (H2S) on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow...
  29. ncbi [Effects of lanthanum on inhibition of lipopolysaccharide induced NF-kappaB activation]
    Fei Guo
    Burn Institute of Nanchang University, Nanchang 330006, P R China
    Zhonghua Shao Shang Za Zhi 23:117-21. 2007
    ..To investigate the influence of lanthanum on lipopolysaccharide (LPS) induced NF-KB activation in murine peritoneal macrophage...
  30. pmc Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription
    S K Hansen
    University Institute of Microbiology, Copenhagen, Denmark
    Mol Cell Biol 14:2593-603. 1994
    ..this activity from the HeLa cell cytosol and have shown that it represents a performed heteromeric complex between p65 (RelA) and c-Rel...
  31. ncbi Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK
    Holger Buss
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 279:55633-43. 2004
    Phosphorylation of NF-kappaB p65(RelA) serine 536 is physiologically induced in response to a variety of proinflammatory stimuli, but the responsible pathways have not been conclusively unraveled, and the function of this phosphorylation ..
  32. ncbi [Effects of Lactobacilli on regulating NF-kappaB activation and IL-8 secretion in SGC7901 cell impacted by Helicobacter pylori]
    Feng Zhen Ma
    Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 38:795-8. 2007
    ..In vitro to investigate the regulation effects of Lactobacillus acidophilus ATCC4356 and L. bulgaricus (LB) on the activation of NF-kB and IL-8 secretion of SGC7901 cell, which Helicobacter pylori induced...
  33. doi The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases
    Baocun Sun
    Department of Pathology, Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China
    Cancer Sci 99:1355-61. 2008
    This study aimed to evaluate the diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma (SS) in known and potential cases...
  34. ncbi Age- and experience-dependent expression of dynamin I and synaptotagmin I in cat visual system
    Lieselotte Cnops
    Laboratory of Neuroplasticity and Neuroproteomics, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Comp Neurol 504:254-64. 2007
    Dynamin I (Dyn I) and Synaptotagmin I (Syt I) are essential for endocytosis-exocytosis processes, thus for neurotransmission...
  35. pmc Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy
    Angela Siciliano
    Dept of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Haematologica 96:24-32. 2011
    ..Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is only partially understood...
  36. ncbi [Expression of NF-kappa B in human bladder cancer and its clinical significance]
    Dong Hua Xie
    Department of Urology, First People s Hospital of Shanghai, Shanghai 200080, P R China
    Ai Zheng 21:663-7. 2002
    ..This study was designed to investigate the expression differences of NF-kappa B and its regulated genes between human primary transitional cell carcinoma(TCCs) of bladder and non-cancer bladder mucosa and its clinical significance...
  37. ncbi Real-time polymerase chain reaction as an aid for the detection of SYT-SSX1 and SYT-SSX2 transcripts in fresh and archival pediatric synovial sarcoma specimens: report of 25 cases from St. Jude Children's Research Hospital
    D Ashley Hill
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Pediatr Dev Pathol 6:24-34. 2003
    ..children and adolescents and is characterized by a reciprocal t(X;18)(p11;q11) which results in the fusion of the SYT gene on chromosome 18q11 to either of two closely related genes, SSX1 (Xp11.23) or SSX2 (Xp11.21)...
  38. ncbi [Expression of NMBR in myometrium in pregnant mice at different gestational ages and its relation with parturition]
    Weishe Zhang
    Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 34:531-6. 2009
    ..To investigate the spatiotemporal expression of neuromedin B receptor (NMBR) in mice myometrium at different pregnant stages, as well as its mechanism and relation with parturition...
  39. ncbi Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients
    Marc Ladanyi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:135-40. 2002
    ..They consistently show a specific t(X;18;p11;q11), which usually represents either of two gene fusions, SYT-SSX1 or SYT-SSX2, encoding putative transcriptional proteins differing at 13 amino acid positions...
  40. pmc Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
    C Kunsch
    Department of Gene Regulation, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    Mol Cell Biol 12:4412-21. 1992
    Analysis of the p50 and p65 subunits of the NF-kappa B transcription factor complex has revealed that both proteins can interact with related DNA sequences through either homo- or heterodimer formation...
  41. ncbi Effect of forskolin on synaptotagmin IV protein trafficking in PC12 cells
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama
    J Biochem 136:245-53. 2004
    Synaptotagmin IV (Syt IV) was originally described as an immediate early gene product induced by forskolin or membrane depolarization in PC12 cells; however, nothing is known about the subcellular localization and transport of the newly ..
  42. doi A novel 65 kDa RNA-binding protein in squid presynaptic terminals
    D T P Lico
    Department of Cellular and Molecular Biology, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo 14049 900, Brazil
    Neuroscience 166:73-83. 2010
    ..antibody (C4), raised against the head domain of chicken myosin Va, reacted strongly towards a 65 kDa polypeptide (p65) on Western blots of extracts from squid optic lobes but did not recognize the heavy chain of squid myosin V...
  43. ncbi Exchange of a nuclear corepressor between NF-kappaB and CREB mediates inhibition of phosphoenolpyruvate carboxykinase transcription by NF-kappaB
    Jin hua Yan
    Department of Endocrinology, Third Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510630, China
    Chin Med J (Engl) 123:221-6. 2010
    NF-kappaB p65 was shown to inhibit transcription of phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme in gluconeogenesis in the liver...
  44. doi Naturally occurring phenolic acids inhibit 12-O-tetradecanoylphorbol-13-acetate induced NF-kappaB, iNOS and COX-2 activation in mouse epidermis
    Michał Cichocki
    Poznan University of Medical Sciences, Department of Pharmaceutical Biochemistry, Swiecickiego 4, 60 781 Poznan, Poland
    Toxicology 268:118-24. 2010
    ..15min prior to TPA resulted in a significant decrease in the NF-kappaB activation which was measured in terms of p65-DNA binding...
  45. ncbi Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma
    Dafydd G Thomas
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
    Cancer 103:830-8. 2005
    ..The majority of synovial sarcomas harbor a specific chromosomal translocation in which the proximal portion of the SYT gene at chromosome 18q11 is fused to the distal portion of one of several duplicated SSX genes (most notably SSX1 ..
  46. doi Effect of salvia miltiorrhizae on apoptosis and NF-kappaB p65 expression in the liver of rats with severe acute pancreatitis or obstructive jaundice
    Xiping Zhang
    Department of General Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    J Gastroenterol Hepatol 24:841-52. 2009
    ..To investigate the therapeutic effects and mechanism of salvia miltiorrhizae in the treatment of severe acute pancreatitis (SAP) or obstructive jaundice (OJ)...
  47. pmc The proline-rich P65 protein of Mycoplasma pneumoniae is a component of the Triton X-100-insoluble fraction and exhibits size polymorphism in the strains M129 and FH
    T Proft
    Zentrum für Molekulare Biologie Heidelberg, Mikrobiologie, Universitat Heidelberg, Germany
    J Bacteriol 177:3370-8. 1995
    Previously, we described the identification of a novel Mycoplasma pneumoniae M129 protein, named P65 because of its apparent molecular mass of 65 kDa estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (T. Proft and R...
  48. ncbi Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis
    Shufang Wu
    Section of Endocrinology and Diabetes, St Christopher s Hospital For Children, Department of Pediatrics, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134, USA
    J Biol Chem 282:33698-706. 2007
    ..we studied the effects of two NF-kappaB inhibitors (pyrrolidine dithiocarbamate (PDTC) or BAY11-7082 (BAY)), p65 short interference RNA (siRNA), and of the overexpression of p65 on chondrocyte proliferation, differentiation, and ..
  49. ncbi Involvement of nuclear factor kappa B in the regulation of rat luteal function: potential roles as survival factor and inhibitor of 20alpha-hydroxysteroid dehydrogenase
    C M Telleria
    Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069, USA
    J Mol Endocrinol 32:365-83. 2004
    ..Western analysis and immunohistochemistry revealed that p65 and p50 were highly expressed throughout pregnancy and were located in both the nucleus and cytoplasm of luteal ..
  50. doi Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis
    Gautam Sethi
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Res 6:1059-70. 2008
    ..of the activation of I kappa B alpha kinase, I kappa B alpha phosphorylation, I kappa B alpha degradation, p65 phosphorylation, p65 nuclear translocation, and the NF-kappa B-dependent reporter gene expression...
  51. ncbi NFkappaB-p65 dependent transcriptional regulation of glycosyltransferases in human colon adenocarcinoma HT-29 by stimulation with tumor necrosis factor alpha
    Koji Higai
    Department of Clinical Chemistry, School of Pharmaceutical Sciences, Toho University, Chiba, Japan
    Biol Pharm Bull 29:2372-7. 2006
    ..and sialyltransferases (STs) in a human colon adenocarcinoma cell line HT-29 and nuclear factor kappaB (NFkappaB)-p65 knockdown HT-29 cells was investigated after stimulation with tumor necrosis factor alpha (TNFalpha) using real ..
  52. pmc Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation
    Yun Dai
    Department of Medicine, Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia 23298, USA
    Mol Cell Biol 25:5429-44. 2005
    NF-kappaB activation is reciprocally regulated by RelA/p65 acetylation and deacetylation, which are mediated by histone acetyltransferases (HATs) and deacetylases (HDACs)...
  53. ncbi Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators
    M L Schmitz
    Institute of Biochemistry, Albert Ludwigs University, Freiburg, Federal Republic of Germany
    J Biol Chem 270:7219-26. 1995
    We show that the transactivating COOH terminus of the p65 subunit of human transcription factor NF-kappa B directly binds the general transcription factors TFIIB and TATA-binding protein (TBP) in vitro...
  54. ncbi Clinical impact of molecular and cytogenetic findings in synovial sarcoma
    I Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Genes Chromosomes Cancer 31:362-72. 2001
    ..This translocation results in rearrangements of the SYT gene in 18q11 and one of the SSX1, SSX2, or SSX4 genes in Xp11, creating a SYT/SSX1, SYT/SSX2, or SYT/SSX4 chimeric ..
  55. doi Effect of phenol on the aggregation characteristics of an ethylene oxide-propylene oxide triblock copolymer P65 in aqueous solution
    J P Mata
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Colloid Interface Sci 320:275-82. 2008
    ..oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (PEO-PPO-PEO) amphiphilic copolymer (Pluronic P65: EO19 PO30 EO19) in aqueous solution have been studied by cloud point, viscosity, dynamic light scattering (DLS), ..
  56. ncbi Increased plasma membrane localization of O-glycosylation-deficient mutant of synaptotagmin I in PC12 cells
    Eiko Kanno
    Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba ku, Sendai, Miyagi, Japan
    J Neurosci Res 86:1036-43. 2008
    Synaptotagmin I (Syt I) is a Ca2+-binding protein on synaptic vesicles and presumably functions as a Ca2+ sensor for neurotransmitter release...
  57. pmc Hepatic preconditioning of doxorubicin in stop-flow chemotherapy: NF-kappaB/IkappaB-alpha pathway and expression of HSP72
    Hui Lu
    Shanghai Institute of Digestive Surgery, Rujin Hospital, Shanghai Second Medical University, Ruijin Road II, Shanghai 200025, China
    World J Gastroenterol 11:2136-41. 2005
    ..To provide hepatic protection through administration of doxorubicin before stop-flow chemotherapy (SFC) and to investigate the expression of heat shock protein 72 (HSP72) and role of nuclear factor kappa B (NF-kappaB) in this effect...
  58. pmc Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation
    Mourad Zerfaoui
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    J Immunol 185:1894-902. 2010
    ..In this study, we show that PARP-1 inhibition by gene knockout, knockdown, or pharmacologic blockade prevented p65 NF-kappaB nuclear translocation in smooth muscle cells upon TLR4 stimulation, NF-kappaB DNA-binding activity, and ..
  59. ncbi Structure and self assembly of pluronic amphiphiles in ethylammonium nitrate and at the silica surface
    Rob Atkin
    Centre for Organic Electronics, The University of Newcastle, Callaghan, NSW, 2308, Australia, School of Chemistry, The University of Sydney, NSW, 2006, Australia, and Hahn Meitner Institute, Glienicker Str 100, 14109 Berlin, Germany
    J Phys Chem B 113:12201-13. 2009
    The self-assembled structures formed by three Pluronic surfactants (P65, L81, L121) in ethylammonium nitrate (EAN, a protic room temperature ionic liquid) in bulk solution and at the silica-EAN interface have been investigated using ..
  60. doi Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration
    Taichi Kimura
    Laboratory of Molecular and Cellular Pathology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Lab Invest 89:645-56. 2009
    b>SYT-SSX protein, resulted from chromosomal translocation, causes synovial sarcoma, which is a malignant tumor accounting for 10% of soft tissue sarcoma...
  61. ncbi Vesicle-associated membrane protein-2/synaptobrevin binding to synaptotagmin I promotes O-glycosylation of synaptotagmin I
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 277:30351-8. 2002
    Synaptotagmin I (Syt I), an evolutionarily conserved integral membrane protein of synaptic vesicles, is now known to regulate Ca2+-dependent neurotransmitter release...
  62. pmc The Leishmania donovani lipophosphoglycan excludes the vesicular proton-ATPase from phagosomes by impairing the recruitment of synaptotagmin V
    Adrien F Vinet
    INRS Institut Armand Frappier and Centre for host parasite interactions, Laval, Quebec, Canada
    PLoS Pathog 5:e1000628. 2009
    We recently showed that the exocytosis regulator Synaptotagmin (Syt) V is recruited to the nascent phagosome and remains associated throughout the maturation process...
  63. ncbi Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding
    Jing Hu
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Building 567, Room 188, Frederick, MD 21702, USA
    Mol Cancer Res 3:100-9. 2005
    ..Electrophoretic mobility shift assay studies showed that trichostatin A treatment prevents p65 dimer binding to NF-kappaB sites on DNA...
  64. ncbi Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101
    Jianming Duan
    National Institute on Deafness and Other Communication Disorders, NIH, CRC Building 10, Room 4 2732, 10 Center Drive, Bethesda, MD 20892, USA
    Mol Cancer Ther 6:37-50. 2007
    ..HNSCC), in which we have shown the activation of nuclear factor-kappaB (NF-kappaB; NF-kappaB1/RelA or p50/p65), a transcription factor that promotes expression of proliferative and antiapoptotic genes...
  65. doi Differential distribution of synaptotagmin-1, -4, -7, and -9 in rat adrenal chromaffin cells
    Hidetada Matsuoka
    Department of Cell and Systems Physiology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, 807 8555, Japan
    Cell Tissue Res 344:41-50. 2011
    ..The present work was undertaken to identify the synaptotagmin (Syt) isoforms present in secretory vesicles...
  66. ncbi Expression of SODD and P65 in ALL of children and its relationship with chemotherapeutic drugs
    Hongfang Tao
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 27:326-9. 2007
    ..expression of silence of death domains (SODD) and its clinical significance and relationship with phospho-NF-kappaB-p65 proteins in bone marrow cells of childhood acute lymphoblastic leukaemia (ALL) were explored, and the expression of ..
  67. pmc Nuclear factor kappa B: a marker of chemotherapy for human stage IV gastric carcinoma
    You Ming Long
    Clinical College, Guangdong Pharmaceutical University, and Carcinoma Department, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou 510080, Guangdong Province, China
    World J Gastroenterol 14:4739-44. 2008
    ..To detect the nuclear factor kappa B (NF-kappaB) condition in human stage IV gastric carcinoma patients and to explore the correlation between NF-kappaB activation and survival of these patients after chemotherapy...
  68. ncbi Roles of SNARE proteins and synaptotagmin I in synaptic transmission: studies at the Drosophila neuromuscular synapse
    Yoshi Kidokoro
    Institute for Behavioral Sciences, Gunma University School of Medicine, Maebashi, Japan
    Neurosignals 12:13-30. 2003
    ..e. neuronal Synaptobrevin (n-Syb), SNAP-25 and Syntaxin 1A (Syx 1A), and Synaptotagmin I (Syt I) in synaptic transmission have been studied in situ using mutant embryos or larvae that lack these molecules or ..
  69. ncbi Increased expression of NF-kappa B subunits in human pancreatic cancer cells
    Nicole M Chandler
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA, USA
    J Surg Res 118:9-14. 2004
    ..We compared the relative expression of NF-kappa B subunits with nuclear activation of p65 between variably differentiated pancreatic cancer cells.
  70. doi The effect of SYT-SSX and extracellular signal-regulated kinase (ERK) on cell proliferation in synovial sarcoma
    Wenjuan Cai
    Department of Pathology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People s Republic of China
    Pathol Oncol Res 17:357-67. 2011
    ..2;q11.2), which results in the fusion of the SYT gene with a SSX gene...
  71. pmc Differential expression and function of synaptotagmin 1 isoforms in Caenorhabditis elegans
    Eleanor A Mathews
    Program in Molecular, Cell and Developmental Biology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Mol Cell Neurosci 34:642-52. 2007
    b>Synaptotagmin 1, encoded by the snt-1 gene in Caenorhabditis elegans, is a major synaptic vesicle protein containing two Ca(2+)-binding (C2) domains...
  72. ncbi [Relationship between glomerular lesion and NF-kappaB p65 activity in rat multiple organ failure caused by zymosan]
    Xue mei Chen
    Department of Emergency, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 21:486-8, 492. 2005
    To observe the relationship between NF-kappaB p65 activity and glomerular lesion in rat multiple organ failure (MOF) caused by zymosan.
  73. ncbi [Effect of activation of nuclear factor-KappaB on modulation of secretion of intercellular adhesion molecule-1 by A549 cell]
    Pin hu Liao
    Coronary Care Unit, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:151-4. 2009
    ..To investigate the effects of interleukin-1beta (IL-1beta) on intercellular adhesion molecule-1 (ICAM-1) expression on A549 cell and underlying signal transduction pathways...
  74. pmc Synaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblasts
    I Martinez
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cell Biol 148:1141-49. 2000
    Synaptotagmins (Syts) are transmembrane proteins with two Ca(2+)-binding C(2) domains in their cytosolic region. Syt I, the most widely studied isoform, has been proposed to function as a Ca(2+) sensor in synaptic vesicle exocytosis...
  75. ncbi Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB
    Suparna Qanungo
    Department of Anatomy, Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 282:18427-36. 2007
    ..and Nieminen, A. L. (2004) J. Biol. Chem. 279, 50455-50464). Here, we examined sulfhydryl modifications of the p65 subunit of NFkappaB that are responsible for NFkappaB inactivation...
  76. ncbi The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type)
    Roy Cohen
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Biol Chem 278:9258-66. 2003
    Biochemical and genetic studies implicate synaptotagmin (Syt 1) as a Ca2+ sensor for neuronal and neuroendocrine neurosecretion. Calcium binding to Syt 1 occurs through two cytoplasmic repeats termed the C2A and C2B domains...
  77. pmc Activation of the serum response factor by p65/NF-kappaB
    G Franzoso
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 15:3403-12. 1996
    This study demonstrates that the NF-kappaB subunit p65 can act like an accessory protein for the serum response factor (SRF) in transfection assays...
  78. doi Titration of synaptotagmin I expression differentially regulates release of norepinephrine and neuropeptide Y
    J B Papke
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, United States
    Neuroscience 218:78-88. 2012
    Synaptotagmin (syt) I is a Ca(2+) sensor that has been thought to trigger all vesicle secretion with similar mechanisms...
  79. ncbi [Protective effect of hydrogen sulfide on rats with myocardial ischemia/reperfusion injury and its mechanism]
    Yansheng Zhang
    Department of Anesthesia, First Affiliated Hospital, University of South China, Hengyang 421001, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31:316-20. 2015
    ..Keap 1 and intranuclear nuclear factor-erythroid 2-related factor 2 (Nrf2) and nuclear factor-κB (NF-κB) p65 in myocardium were measured using Western blotting...
  80. ncbi Transcriptional silencing of the death gene BNIP3 by cooperative action of NF-kappaB and histone deacetylase 1 in ventricular myocytes
    James Shaw
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre Rm 3016, 351 Tache Avenue, Winnipeg, Manitoba, Canada, R2H 2A6
    Circ Res 99:1347-54. 2006
    ..Basal Bnip3 gene expression was increased in cells derived from p65(-/-) deficient mice...
  81. doi Functional analysis of histone demethylase Jmjd2b on lipopolysaccharide-treated murine neural stem cells (NSCs)
    Nando Dulal Das
    Division of Molecular and Life Science, Hanyang University, 1271 Sa 3 dong, Gyeonggi Do, Ansan 426 791, Korea
    Neurotox Res 23:154-65. 2013
    ..The attenuation of Jmjd2b in NE-4C cells significantly affected the p65, iNOS, Bcl2, and TGF-β expression levels and had downstream effects on related signaling pathways...
  82. pmc Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock
    Kiran K Nandra
    William Harvey Research Institute, Barts and London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    Dis Model Mech 6:701-9. 2013
    ..In the liver, HS also caused an increase in nuclear translocation of p65 (activation of NF-κB), which was attenuated by EPO...
  83. ncbi Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor
    Jun Sun
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 291:E315-22. 2006
    ..Consistent with IkappaBalpha reduction, p65 accumulation in the nucleus was markedly increased in unstimulated VDR-/- cells...
  84. ncbi Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity
    Sandip Bhattacharyya
    Department of Microbiology and Immunology, Mary Ellen Jones Bldg, Rm 804, Campus Box 7290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290
    Blood 104:1100-9. 2004
    ..but not IkappaBbeta and by reduced phosphorylation of Ser536, located in the trans-activation domain of p65. Notably, IL-10-mediated inhibition of NF-kappaB coincided with suppressed IkappaB kinase (IKK) activity in vitro...
  85. ncbi A novel mechanism of tissue inhibitor of metalloproteinases-1 activation by interleukin-1 in primary human astrocytes
    Katarzyna M Wilczynska
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    J Biol Chem 281:34955-64. 2006
    ..SB202190, overexpression of the dominant-negative inhibitor of NF-kappaB (IkappaBalphaSR), or by the knock-down of p65 subunit of NF-kappaB...
  86. ncbi NF-kappaB-associated MnSOD induction protects against beta-amyloid-induced neuronal apoptosis
    Pradoldej Sompol
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    J Mol Neurosci 29:279-88. 2006
    ..activates NF-kappaB activity in neuronal, SH-SY5Y, cells and preferentially enhances the binding of p50 and p65 to the promoter/enhancer regions of the MnSOD gene...
  87. doi Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation
    Jie Li
    Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210008, PR China
    Neurosci Lett 535:51-6. 2013
    ..OGD enhanced the phosphorylation of p38 and nuclear translocation of p65 in BV2 microglia, which was partially reserved by HSYA...
  88. ncbi Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4
    V J Green
    Gene Regulation Laboratory and Macromolecular Crystallography Unit, Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:29950-7. 1998
    ..structural motifs and molecular targets with the activators of the tumor suppressor protein p53 and NF-kappaB-p65, suggesting similar mechanisms of action...
  89. ncbi Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility
    Runqing Lu
    The Sidney Kimmel Comprehensive Cancer Center and the Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 277:16592-8. 2002
    ..mobility shift assays, we have demonstrated that an NFkappaB site located next to the TATA box, binds p50 and p65 heterodimer and is required for the induction of the IRF-7 gene by TPA and TNFalpha...
  90. pmc Advanced Glycation End-Products Induce Apoptosis in Pancreatic Islet Endothelial Cells via NF-κB-Activated Cyclooxygenase-2/Prostaglandin E2 Up-Regulation
    Kuo Cheng Lan
    Department of Emergency Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 10:e0124418. 2015
    ..Treatment of MS1 cells with AGEs also resulted in increased nuclear factor (NF)-κB-p65 phosphorylation and cyclooxygenase (COX)-2 expression...
  91. doi A synthetic peptide derived from A1 module in CRD4 of human TNF receptor-1 inhibits binding and proinflammatory effect of human TNF-alpha
    Yingnan Cao
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    Inflammation 32:139-45. 2009
    ..of TNF-alpha to TNF-R1 and protein levels of IkappaB-alpha and nuclear transcription factor kappa B (NF-kappaB) p65 subunit in HeLa cells were measured using enzyme-linked immunosorbent assay (ELISA) and western-blot analysis...
  92. doi Activation of striatal inflammatory mediators and caspase-3 is central to haloperidol-induced orofacial dyskinesia
    Mahendra Bishnoi
    Centre with Potential for Excellence in Biomedical Sciences CPEBS, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 590:241-5. 2008
    ..higher doses (2 and 5 mg/kg), increased levels of total nitric oxide and TNF-alpha in cytoplasmic lysate and active p65 subunit of NF-kappaB in nuclear lysates of rat brain were observed...
  93. doi Novel anti-nociceptive effects of cardamonin via blocking expression of cyclooxygenase-2 and transglutaminase-2
    Mi Kyung Park
    BK21PLUS R FIND team, College of Pharmacy, Dongguk University, Seoul 100 715, Republic of Korea
    Pharmacol Biochem Behav 118:10-5. 2014
    ..CDN suppressed the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restored the expression of IκB in MG63 and Raw264...
  94. pmc The effect of proteasome inhibitor MG132 on experimental inflammatory bowel disease
    S Inoue
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Exp Immunol 156:172-82. 2009
    ..findings and tumour necrosis factor (TNF)-alpha mRNA expression, epithelial cell proliferation and NF-kappaB p65 activity in colonic tissues were examined...
  95. pmc ROCK/NF-κB axis-dependent augmentation of angiotensinogen by angiotensin II in primary-cultured preglomerular vascular smooth muscle cells
    Kayoko Miyata
    Dept of Physiology and Hypertension and Renal Center of Excellence, Tulane Univ Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112 2699
    Am J Physiol Renal Physiol 306:F608-18. 2014
    ..interfering (si) RNA suppressed the ANG II-induced AGT augmentation and the upregulation and translocalization of p65 into nuclei...
  96. pmc Gender dimorphism of the cardiac dysfunction in murine sepsis: signalling mechanisms and age-dependency
    Jianmin Chen
    Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    PLoS ONE 9:e100631. 2014
    ..Akt and eNOS; ii) significant decreases in phosphorylation of IκBα, nuclear translocation of the NF-κB subunit p65, decreased expression of iNOS and decreased synthesis of TNF-α and IL-6 in the heart...
  97. doi Pseudoephedrine inhibits T-cell activation by targeting NF-κB, NFAT and AP-1 signaling pathways
    Bernd L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    Immunopharmacol Immunotoxicol 34:98-106. 2012
    ..However, phosphorylation of the p65/RelA subunit was clearly inhibited by PSE in stimulated cells...
  98. doi Synthesis of phenylisothiourea derivatives as inhibitors of NO production in LPS activated macrophages
    Guo Hua Jin
    College of Pharmacy, Sookmyung Women s University, Seoul, Republic of Korea
    Bioorg Med Chem Lett 19:3088-92. 2009
    ..They inhibited NO production through the suppression of the LPS-induced translocation of p65 subunit of NF-kappaB and the followed suppression of the iNOS protein and mRNA expression.
  99. doi Imipramine exploits histone deacetylase 11 To Increase the IL-12/IL-10 ratio in macrophages infected with antimony-resistant Leishmania donovani and clears organ parasites in experimental infection
    Sandip Mukherjee
    Department of Infectious Diseases and Immunology, Council of Scientific and Industrial Research Indian Institute of Chemical Biology, Kolkata 700032, India
    J Immunol 193:4083-94. 2014
    ..It abrogates Sb(R)LD-mediated p50/c-Rel binding to IL-10 promoter and preferentially recruits p65/RelB to IL-12 p35 and p40 promoters, causing a decrease in IL-10 and overproduction of IL-12 in Sb(R)LD-Mϕs...
  100. doi Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors
    Isao Momose
    Institute of Microbial Chemistry, Numazu, Japan
    Cancer Sci 105:1609-15. 2014
    ..derivatives also suppress the degradation of the NF-κB inhibitor IκB-α and the nuclear translocation of NF-κB p65 in multiple myeloma cells, resulting in the inhibition of NF-κB activation...
  101. doi Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma
    Wen Feng Chu
    Department of Pharmacology, Harbin Medical University, Baojian Road 157, Harbin, Heilongjiang 150081, PR China
    Oral Oncol 45:998-1004. 2009
    ..Furthermore, levels of nuclear factor-kappaB (NF-kappaB) p65 in both of the cytoplasm and the nucleus have also been markedly suppressed by SFN in a time-dependent manner...

Research Grants75

  1. Hypothermia enhances inflammatory cytokine expression via NF-kappa B
    Karen D Fairchild; Fiscal Year: 2010
    ..Our preliminary data show that HT alters key phosphorylation and acetylation events which favor association of the p65 transactivation component of NF-/kB with cytokine gene promoters on chromatin...
  2. Control of NF-kappaB Activity
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    ..growth factor (EGF)-induced histone H3 serl0 phosphorylation and that GSK-313 controls the phosphorylation of the p65 subunit on ser536...
  3. Investigation of Gene Regulation by NF-kappaB Transcription factors
    Gourisankar Ghosh; Fiscal Year: 2012
    ..The combinatorial NF-?B dimers are formed from five family members;p50, p52, RelA (p65), cRel and RelB...
  4. NF-kappaB Inhibitors and Differentiation-Inducers in Leukemia
    Steven Grant; Fiscal Year: 2011
    ..Insights generated during the preceding funding period have led us to the hypothesis that NF-kappaB/p65 acetylation/nuclear translocation/activation plays a pivotal role in protecting leukemic cells from HDACI-mediated ..
  5. Inflammatory Cytokines Link NF-kappaB with Bim Degradation and Metastasis
    Marty W Mayo; Fiscal Year: 2012
    ..Preliminary data presented in this proposal indicate that the p65 component of NF-?B provides a novel avenue of cell survival by blocking detachment from the extracellular matrix...
  6. Epigenetics of Severe Systemic Inflammation
    CHARLES EMORY MCCALL; Fiscal Year: 2013
    ..silencing signature requires Toll-like receptor 4 (TLR4) induction of NF-kappa B factor RelB that disrupts p65 promoter binding, directs histone H3K9 di-methylation by G9a to provide a binding site of heterochromatin protein 1 ..
  7. NF kappa B Activity in Skin Inflammation and Carcinogenesis
    Brian Poligone; Fiscal Year: 2013
    ..We have constructed a novel mouse model to examine the NF-KB pathway in skin. The homozygous p65 S276D (PD) knock-in mouse contains a mutant form of NF-KB that increases the basal transcriptional activation of NF-..
  8. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..Aim 2 will determine the role of p65 as an activator or repressor of polycomb-mediated gene expression...
  9. Ras-Induced Lung Cancer: Key Roles for IKK and NF-kappaB
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    ..test for a role of NF-?B in oncogene-induced tumorigenesis, we show here that loss of the gene encoding the RelA/p65 NF-?B subunit suppresses Ras-induced tumorigenesis in a lung tumor model...
  10. Wiring the UV Signaling Circuitry
    Anning Lin; Fiscal Year: 2012
    ..Specifically, RelA/p65, which is a major transactivating subunit of the NF-kappaB family, in its pre-existing nuclear form controls ..
  11. Regulation of NF-kappaB transactivation function
    BRIAN ASHBURNER; Fiscal Year: 2009
    ..These signals are thought to target the C-terminal transcriptional activation domain (TAD) of the p65 subunit of NF-kB and likely function to regulate the association of transcriptional coactivator and corepressor ..
  12. Small Molecule Inhibitors of the Transcriptional Activators ESX and NF-kB
    Anna K Mapp; Fiscal Year: 2013
    ..small (drug-like) molecules that inhibit the function of two transcriptional activators, ESX and NF- kappaB (p50/p65 heterodimer) implicated in approximately 30% of breast cancers...
  13. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
    ..with an inhibitory protein known as IkappaB and another mechanism involves direct phosphorylation of the p65 subunit of NF-kappaB which controls transactivation potential...
  14. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2009
    ..Our recent studies (Neoplasia Vol.6 No.4, 2004) have shown that NF-kappaB/p65 is constitutively activated in human prostate adenocarcinoma and correlates with disease progression...
  15. Regulation of NF-kB transcriptional activity
    Sankar Ghosh; Fiscal Year: 2009
    ..However, studies carried out in our laboratory have demonstrated that the p65 subunit of NF-kappaB has to be phosphorylated to become competent for transcription...
  16. Interleukin-8 Regulation by Proteasome and Nuclear IkB in Cancer and Inflammation
    Ivana Vancurova; Fiscal Year: 2013
    ..The central hypothesis is that S536 p65 phosphorylation, specificity of the DNA sequence of the NF?B binding site, and/or the transcription factor EGR-1 ..
  17. Role of JAK2 in Innate Immunity
    Richard J Lamont; Fiscal Year: 2013
    ..JAK2, JAK3, and TYK2 recruitment to TLR2;(5) inhibition of JAK2 resulted in the abrogated activation of the NF-:B p65 signaling pathway;(6) JAK2 was activated in mice challenged with P...
  18. Regulation of Innate Immunity by Pyrin Proteins
    Jonathan A Harton; Fiscal Year: 2012
    ..Specifically, we have identified a second human POP (POP2) which inhibits NF-kB p65 activity, interacts with ASC, and prevents the activation of a number of NLR activated inflammasomes...
  19. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..First, are the cytoprotective effects of TRAF2 mediated by activation of the type 1 NF-?B pathway, and if so are p65 and p50 homo or heterodimers involved (Specific Aim 1)? Second, is dysferlin necessary for the cytoprotective ..
  20. Single-cell analysis of TNF-induced signaling, transcription and fate decisions
    Suzanne Gaudet; Fiscal Year: 2013
    ..Finally, we will use protein-binding microarrays to ask how competition between p65-p50 heterodimers and p50-p50 homodimers contributes to decoding NF-kB activation and to cell line-to-cell line ..
  21. Endothelial Insulin Resistance, Inflammation and Vascular Function in Diabetes
    NAOMI MIRIAM HAMBURG; Fiscal Year: 2013
    ..eNOS expression, insulin-mediated eNOS phosphorylation) and evidence of endothelial inflammatory activation (I:2, p65, ICAM expression) in endothelial cells freshly isolated from human subjects to the presence of diabetes and to the ..
  22. Hypercapnia and pulmonary host defense
    Khalilah L Gates; Fiscal Year: 2010
    ..preliminary studies show that hypercapnia suppresses macrophage synthesis of multiple cytokines regulated by NF-:B p65/Rel A that are critical for host defense, and also inhibits phagocytosis...
  23. TREM-1 in Lung Immune Response
    Ruxana T Sadikot; Fiscal Year: 2013
    ..three interrelated specific aims:1) Define the molecular mechanisms by which TREM-1 expression is regulated by p65 and PU.1 in vitro in macrophages in response to P.aeruginosa...
  24. Intestinal Microbiota, Diet and Risk of Colorectal Adenomas
    Robert S Sandler; Fiscal Year: 2013
    ..IL-4, IL-17, INF(, IL-8, IL-10 and TGF-(;macrophages, NK cells, T cells- CD4+ and CD8+;protein expression of NF-(B (p65) and STAT3) among subjects with and without adenomas, 3) assess the association between adherent bacteria profiles ..
  25. STUDIES OF THE FATE OF THE OSTEOCLAST
    Brendan F Boyce; Fiscal Year: 2013
    ..Expression of these is essential for osteoclast formation. RANKL/RANK signals through a canonical NF-?B1/p65 and an alternative NF-?B2/RelB pathway...
  26. Eosinophil:M2 Macrophage:CCL11 Axis in Experimental Colitis and Pediatric Cortico
    SIMON PATRICK HOGAN; Fiscal Year: 2013
    ..we show that colonic M[unreadable]s express the calprotectin receptor (RAGE);and calprotectin stimulates p65 activation and CCL11 expression in M[unreadable]s in vitro...
  27. NF-kappaBeta Therapy for Duchenne Muscular Dystrophy
    Denis C Guttridge; Fiscal Year: 2012
    ..Genetic ablation of either the transcriptionally competent p65 subunit of NFkB or the IKKbeta subunit, that is sensitive to NBD treatment, modulated the immune response and ..
  28. Transcriptional Co-Regulators and Macrophage Gene Expression
    Christopher K Glass; Fiscal Year: 2013
    ..nuclear receptor Nurr1 is induced in response to TLR signaling and recruits CoREST/LSD1 co-repressor complexes to p65 at NFkB-responsive promoters...
  29. Adipose Tissue Hypoxia and Inflammation in Obesity
    Jianping Ye; Fiscal Year: 2013
    ..A role of macrophage in angiogenesis will be investigated in adipocyte-specific NF-kB p65 knockout mice...
  30. Mechanisms of Coronary Arteriolar Dysfunction in Type 2 Diabetes
    Khalid Matrougui; Fiscal Year: 2013
    ..Our preliminary data indicate an increase in oxidative stress (superoxide;O2.-), p65- NFkB activity and PARP-1 activity in coronary arterioles from db-/db- mice...
  31. Mycoplasma pneumoniae Gliding Motility
    Duncan C Krause; Fiscal Year: 2012
    ..Aim 1 addresses the gliding mechanism, focusing on gliding-associated proteins P65, P41 and P24. The terminal organelle detaches from the cell body with the loss of P41 but retains gliding function...
  32. SIMPL-a TNFalpha-specific transcriptional co-activator
    Maureen A Harrington; Fiscal Year: 2010
    ..This proposal focuses on a factor we identified termed SIMPL. SIMPL is a TNF1 regulated p65 specific co- activator...
  33. Regulation of Endothelial ICAM-1 and PMN-Mediated Lung Injury by Actin Dynamics
    Fabeha Fazal; Fiscal Year: 2013
    ..The basis of ICAM-1 expression involves activation of RelA/p65 subunit of the transcription factor NF-(B...
  34. Impact of obesity on airway responses to air pollution
    Stephanie A Shore; Fiscal Year: 2013
    ..We will use EMSA and Western blotting for I?B, p50, and p65 to determine O3-induced NF-?B activation is increased in obese mice...
  35. SPORE in Soft Tissue Sarcoma
    Samuel Singer; Fiscal Year: 2013
    ..Therapy) aims to elucidate the epigenetic mechanisms and histone code alterations involved in the deregulation of SYT-SSX target genes in synovial sarcoma so as to enhance our understanding of synovial sarcoma pathogenesis and guide ..
  36. The role of cellular senescence in intervertebral disc aging
    Nam V Vo; Fiscal Year: 2013
    ..role of NF-?B in mediating the establishment of cellular senescence in discs of mice genetically depleted of the p65 subunit of NF-?B, Aim #2: the metabolic phenotype of senescent disc cells as it relates to PG homeostasis and SASP, ..
  37. ROLE OF CSF-1 IN OSTEOCLAST FUNCTION
    KARL LEONARD INSOGNA; Fiscal Year: 2013
    ..We have discovered that BCA3 regulates CSF1-induced cytoskeletal remodeling and also augments NF:?B p65 signaling. In the second Specific Aim, the role of BCA3 in mediating both CSF1 and RANKL signaling will be explored...
  38. Brain injury due to transcranial versus transthoracic blast exposure
    J Marc Simard; Fiscal Year: 2013
    ..activation of the mechano-sensitive transcription factors, specificity protein 1 (Sp1) and nuclear factor kappaB (p65), and the time-course and cellular localization for the cell death molecules, SUR1, transient receptor potential ..
  39. The role of NF-kB signaling in Aging
    JEREMY SCOTT TILSTRA; Fiscal Year: 2010
    ..Similarly, the role of NF-KB in aging will be analyzed using ERCC1 mutant mice heterozygous for the p65 subunit of NF-KB...
  40. The role of CCR5 in HIV-1 Tat and morphine-mediated neurodegeneration.
    Elizabeth M Podhaizer; Fiscal Year: 2013
    ..Maraviroc is also sufficient to reduce glial NF-?B p65 activation and chemokine release, confirming that CCR5 is a critical mediator of glial inflammatory signaling...
  41. Molecular Mechanisms of Campylobacter Jejuni-induced Pathogenesis
    Christian Jobin; Fiscal Year: 2011
    ..jejuni-induced pathogenesis through genetic removal of the NF?B transcriptional subunit RelA (p65) in the susceptible murine strain IL-10-/-...
  42. Cell Adhesion Control by the Proto-Oncoprotein SYT
    JOSIANE EID; Fiscal Year: 2005
    ..It is characterized by a chromosomal rearrangement between the SYT gene on chromosome 18 and the SSX gene on chromosome x, which results in a fusion product, SYT/SSX...
  43. Suppression of HIV-1 in CNS by a novel protein from ST John's Wort
    Shohreh Amini; Fiscal Year: 2010
    ..studies have ascribed important roles for several transcription factors such as the C/EBPa family, NFkB (p50/p65), and the viral transactivator, Tat, and the late auxiliary protein, Vpr, in these cells...
  44. MODULATION OF NF-kB ACTIVATION BY A NOVEL MITOCHONDRIAL E3 UBIQUITIN LIGASE
    Claudio A P Joazeiro; Fiscal Year: 2012
    ..that MULAN acts as a mitochondrial regulator of NF-[unreadable]B activation, apparently acting upstream of IKK and p65, that MULAN functions by interacting with and activating a downstream effector, and that MULAN's E3 activity ..
  45. Oxidant stress and diabetic endothelial dysfunction
    Ming Hui Zou; Fiscal Year: 2013
    ..hypothesis of this application is that AMPK12 inhibition increases 26S activity, which increases I:B1 degradation, p65 nucleus localization, and consequent NF:B activation...
  46. Anti-inflammatory Assay for Cystic Fibrosis
    Rangan Maitra; Fiscal Year: 2010
    ..a Pseudomonas aeruginosa bacterial filtrate (PAF)-induced image-based translocation assay for the NF?B subunit p65 in CF airway epithelial cells...
  47. Chlamydial modulation of Eukaryotic signaling pathways
    Robert J Bastidas; Fiscal Year: 2012
    ..Activation of NF-kB (p65/RelA)-mediated signaling is important for the initiation of innate and adaptive immune responses...
  48. Role of H-Ras in Retinal Cell Death in Diabetes
    Renu A Kowluru; Fiscal Year: 2013
    ..Our preliminary data show that in diabetes, the recruitment of p65 subunit of NF-kB is increased at retinal MMP-9 promoter and that of dimethylated lysine 9 of histone 3 (H3K9me2) is ..
  49. Radiocontrast Nephropathy: Redox Degradation Catalyst and Nitric Oxide Donor
    ZSUZSANNA KINGA ZSENGELLER; Fiscal Year: 2013
    ..pro-inflammatory transcription factor expression (cytoplasmic I[unreadable]B[unreadable] degradation, nuclear p65 translocation), histologic damage, and nuclear damage and DNA repair (PARP activation and nitrosative stress as ..
  50. Chromatin remodeling mechanisms of gene transcription in memory
    Farah D Lubin; Fiscal Year: 2013
    ..AIM 3. NF-[unreadable]B (p65) is a non-histone target of protein lysine methyltransferases, and once methylated NF[unreadable]B can associate ..
  51. Computational and Functional Characterization of the Molecular Steps in Membran*
    J Troy Littleton; Fiscal Year: 2013
    ..Stimulus evoked fusion is triggered by an influx of Ca2+ ions that interact with a vesicle protein, synaptotagmin (Syt), which is tightly coupled with the SNARE complex...
  52. The role of FOXC1 in basal-like breast cancer
    Xiaojiang Cui; Fiscal Year: 2013
    ..cells and breast cancer cells increased cell proliferation, migration, invasion, and protein levels of NF-kB p65 and ?-catenin...
  53. Molecular Pathways Regulating Airway Goblet Cell Mucin Secretion
    Burton F Dickey; Fiscal Year: 2013
    ..second messengers are the Munc13 priming proteins that bind DAG and Ca2+, and the SNARE-triggering Synaptotagmin (Syt) proteins that bind phospholipids and Ca2+...
  54. Proteasome/HDAC Inhibition in Leukemia/MDS; Phase I Trial and Correlative Studies
    Steven Grant; Fiscal Year: 2010
    ..synergistic manner in cultured and primary AML blasts to induce apoptosis in association with diminished nuclear p65/RelA localization, down-regulation of NF-:B-dependent proteins (Bcl-xL and XIAP), and up- regulation of Bim...
  55. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven L Teitelbaum; Fiscal Year: 2013
    ..Additionally Syt VII regulates OB exocytosis...
  56. Synaptotagmin and C2-Domains: Structure and Function
    JOSE RIZO-REY; Fiscal Year: 2013
    ..Moreover, since many neurological disorders are treated with drugs that alter synaptic transmission, this research is expected to provide crucial clues for the development of novel strategies to understand and treat these disorders. ..
  57. Novel up-regulators of NF-kB activity: effect on MnSOD and TBI in vitro models
    Maurizio Grimaldi; Fiscal Year: 2012
    ..Interestingly, MnSOD is specifically induced by activation of NF-kBs such as p65 and Rel very abundant NF-kB in the brain...
  58. Structural Mechanisms of Botulinum Neurotoxin Pathogenesis
    DANA BORDEN LACY; Fiscal Year: 2012
    ..BoNTs are highly similar but have notable differences in how they interact with the two isoforms of synaptotagmin (SytI and II)...
  59. Role of Tat and SIRT1 in the T-cell Hyperactivation Syndrome Induced by HIV-1
    MELANIE MARIA OTT; Fiscal Year: 2013
    ..Tat directly interacts with the deacetylase domain of SIRT1 and blocks the ability of SIRT1 to deacetylate the RelA/p65 subunit of NF-B...
  60. G PROTEIN STRUCTURE AND FUNCTION
    Heidi E Hamm; Fiscal Year: 2010
    ..was recently shown by our group to be a physiologically very interesting competitive inhibition of synaptotagmin I (Syt1) binding to the C-terminus of SNAP25...
  61. Genome-wide protein-DNA interactions responding to chronic opioid treatment
    Yulong Chen; Fiscal Year: 2012
    ..We will establish this method to analyze genome-wide CBP/p300-NF-:B/p65-DNA interactions in mu and delta opioid receptor-expressing cells after acute and chronic morphine (Specific Aim 1) ..
  62. Role of NF-kB in hematopoietic stem cells and leukemia-initiating cell formation
    Christopher A Klug; Fiscal Year: 2013
    ..provided by applicant): Constitutive activation of the classical NF-?B pathway, which principally involves RelA/p65, c-Rel, and p50, has been observed in human acute myeloid leukemia (AML) where constitutive NF-?B DNA-binding ..
  63. PDLIM2 as a cancer and chemosensitizing target
    Gutian Xiao; Fiscal Year: 2013
    ..PDLIM2 functions as a ubiquitin E3 ligase to selectively degrade nuclear (activated) NF- ?B RelA (also known as p65), a transcription factor that has been suggested to play a causative role in tumorigenesis and therapeutic ..
  64. Impaired B cell Activation/Differentiation via Sustained BCL6 Expression by TCDD
    Norbert E Kaminski; Fiscal Year: 2013
    ..cells, TCDD- treatment caused elevated and sustained levels of BCL6, and decreased levels of CD80, CD69, pERK, p- p65/NF?B, and p-cJun, which are hallmarks of impaired B cell activation...
  65. Next generation of botulinum neurotoxins with enhanced binding to human receptors
    Min Dong; Fiscal Year: 2013
    ..can be improved, as we recently discovered that BoNT/B cannot bind to the major human receptor synaptotagmin II (Syt II) due to a single residue change in human Syt II sequence...
  66. MOLECULAR INSIGHTS INTO CALCIUM REGULATED SECRETION
    LISA ELFERINK; Fiscal Year: 1999
    ..studies into PC12 cells demonstrated that antibodies against the synaptic vesicle protein synaptotagmin (syt) and a recombinant syt fragment, blocked the secretion of catecholamines from PC12 cells, identifying putative ..
  67. Synaptotagmin 4: Role in Vocal Motor Function and Parkinson's Disease.
    Stephanie Ann White; Fiscal Year: 2013
    ..Follow up experiments will then test whether loss of DA, such as occurs in PD, switches Syt 4 regulation to that found in non-vocal areas...
  68. Simultaneous latent HIV reactivation and cytokine gene suppression
    Monty A Montano; Fiscal Year: 2013
    ..At cytokine gene promoters, we hypothesize that JQ1 interferes with acetylated p65/RelA interaction with Brd4 resulting in declines in NF- B driven cytokine gene expression, but not NFAT driven gene ..
  69. Synaptotagmin function in virus movement and plant development
    Sondra G Lazarowitz; Fiscal Year: 2010
    ..SYTA is 1 of 5 Arabidopsis synaptotagmins (SYT A-E)...
  70. Preclinical Trials of NFkappaB Inhibition in the Treatment of Muscular Dystrophy
    C Carlson; Fiscal Year: 2009
    ..Preliminary studies showing an increased total cellular expression of p65 in dystrophic (mdx) muscle also indicate the potential clinical utility of agents that decrease the expression of ..
  71. BIOCHEMISTRY OF SYNAPTIC VESICLES FROM BRAIN
    Erik Floor; Fiscal Year: 1991
    ..The question of whether one major synaptic vesicle protein, p65, is a component of the putative pump will be investigated by cross-linking...
  72. Stoichiometry and Architecture of the Vesicle Fusion Machine in PC-12 Cells
    JAMES WEISSHAAR; Fiscal Year: 2009
    ..attachment receptor) proteins syntaxin (Syx), SNAP-25, and synaptobrevin (Syb), and the Ca2+ sensor synaptotagmin (Syt)...
  73. INDUCTION OF ACUTE PHASE PROTEIN BIOSYNTHESIS
    David Samols; Fiscal Year: 2004
    ..findings did not reflect classic NFkappaB activity; 1) CRP expression was inhibited by over-expressed pp65 and 2) p65 was not found in EMSA complexes...
  74. Homologous Recombination in a Secretory Mouse Cell Line
    AMY HARKINS; Fiscal Year: 2003
    ..Synaptotagmin I (syt I), an integral vesicular protein, has been postulated to act as the Ca2+ sensor for exocytosis...
  75. SPECTROSCOPIC PROBES OF LEAD/PROTEIN INTERACTIONS
    HILARY GODWIN; Fiscal Year: 2003
    ..and human genetics have pinpointed two proteins that are likely targets for lead in vivo: synaptotagmin (Syt) and delta-aminolevulinic acid dehydratase (ALAD)...