SYT1

Summary

Gene Symbol: SYT1
Description: synaptotagmin I
Alias: P65, SVP65, SYT, synaptotagmin 1, synaptotagmin-1, sytI
Species: human

Top Publications

  1. ncbi The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export
    Igor Prudovsky
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    J Cell Biol 158:201-8. 2002
  2. ncbi Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Republic of China
    J Biol Chem 279:26143-8. 2004
  3. ncbi Chromatin-dependent E1A activity modulates NF-kappaB RelA-mediated repression of glucocorticoid receptor-dependent transcription
    Barbara A Burkhart
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:6349-58. 2005
  4. ncbi Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction
    Darren M Hutt
    Ottawa Health Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 280:20197-203. 2005
  5. ncbi The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis
    Yanhua Peng
    Department of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, Florida 33601, USA
    J Gastrointest Surg 10:837-47. 2006
  6. ncbi S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro
    C Mouta Carreira
    Center for Molecular Medicine, Maine Medical Center Research Institute, South Portland, Maine 04106, USA
    J Biol Chem 273:22224-31. 1998
  7. ncbi NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1)
    Karuppanan Muthusamy Kathir
    Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA
    Biochim Biophys Acta 1798:297-302. 2010
  8. ncbi Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling
    J Z Zhang
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 78:751-60. 1994
  9. ncbi Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin
    A Betz
    Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, Hermann Rein Strasse 3, D 37075 Gottingen, Federal Republic of Germany
    J Biol Chem 272:2520-6. 1997
  10. ncbi Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association
    Kerry L Fuson
    Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biochemistry 46:13041-8. 2007

Research Grants

  1. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2001
  2. Regulated Exocytosis of Lysosomes
    Norma Andrews; Fiscal Year: 2007
  3. Regulated Exocytosis of Lysosomes
    Norma Andrews; Fiscal Year: 2009
  4. Targeting the NF-kappaB Pathway in Melanoma
    Ann Richmond; Fiscal Year: 2009
  5. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
  6. Cell Adhesion Control by the Proto-Oncoprotein SYT
    JOSIANE EID; Fiscal Year: 2005
  7. B-Catenin regulation by the Proto-Oncoprotein SYT
    JOSIANE EID; Fiscal Year: 2007
  8. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2007
  9. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2009
  10. ROLE FOR NF-KAPPA B IN RAS-MEDIATED ONCOGENESIS
    ALBERT BALDWIN JR; Fiscal Year: 2002

Detail Information

Publications171 found, 100 shown here

  1. ncbi The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export
    Igor Prudovsky
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    J Cell Biol 158:201-8. 2002
    ..cytosolic pattern to a locale near the inner surface of the plasma membrane where it colocalized with S100A13 and Syt1. In addition, coexpression of dominant-negative mutant forms of S100A13 and Syt1, which both repress the release of ..
  2. ncbi Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Republic of China
    J Biol Chem 279:26143-8. 2004
    ..directly interacts with and activates NF-kappaB led us to examine the phosphorylation status of NF-kappaB p65. Coincident with activation of NF-kappaB, cisplatin induced Ser phosphorylation but decreased Thr phosphorylation ..
  3. ncbi Chromatin-dependent E1A activity modulates NF-kappaB RelA-mediated repression of glucocorticoid receptor-dependent transcription
    Barbara A Burkhart
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:6349-58. 2005
    ..in the repression of glucocorticoid-dependent transcription from the murine mammary tumor virus (MMTV) promoter by p65 and E1A was investigated by using chromatin and transiently transfected reporters...
  4. ncbi Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction
    Darren M Hutt
    Ottawa Health Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 280:20197-203. 2005
    ..and VAMP2, mediates vesicle fusion, whereas calcium regulation is thought to be accomplished by the synaptotagmin (Syt) family, some of which exhibit calcium-dependent binding to syntaxin and SNAP-25...
  5. ncbi The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis
    Yanhua Peng
    Department of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, Florida 33601, USA
    J Gastrointest Surg 10:837-47. 2006
    ..The aim of our study was to determine the role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis...
  6. ncbi S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro
    C Mouta Carreira
    Center for Molecular Medicine, Maine Medical Center Research Institute, South Portland, Maine 04106, USA
    J Biol Chem 273:22224-31. 1998
    ..as a stress-induced pathway in which FGF-1 is released as a latent homodimer with the p40 extravesicular domain of p65 synaptotagmin (Syn)-1...
  7. ncbi NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1)
    Karuppanan Muthusamy Kathir
    Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA
    Biochim Biophys Acta 1798:297-302. 2010
    ..as a multiprotein complex consisting of hFGF-1, S100A13 (a calcium binding protein), and p40 synaptotagmin (Syt1)...
  8. ncbi Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling
    J Z Zhang
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 78:751-60. 1994
    ..Thus, synaptotagmin I may be a multifunctional protein with a function in endocytosis in addition to the previously proposed role in exocytosis...
  9. ncbi Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin
    A Betz
    Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, Hermann Rein Strasse 3, D 37075 Gottingen, Federal Republic of Germany
    J Biol Chem 272:2520-6. 1997
    ..It is possible that the phenotype of unc-13 and unc-18 mutations is caused by the inability of the respective mutated gene products to bind to syntaxin...
  10. ncbi Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association
    Kerry L Fuson
    Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biochemistry 46:13041-8. 2007
    Release of neurotransmitter from synaptic vesicles requires the Ca2+/phospholipid-binding protein synaptotagmin 1. There is considerable evidence that cooperation between the tandem C2 domains of synaptotagmin is a requirement of ..
  11. ncbi Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins
    M Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    Biochem Biophys Res Commun 281:1226-33. 2001
    Synaptotagmins (Syt), rabphilin-3A, and Doc2 belong to a family of carboxyl terminal type (C-type) tandem C2 proteins and are thought to be involved in vesicular trafficking...
  12. ncbi SV2B regulates synaptotagmin 1 by direct interaction
    Diana R Lazzell
    WM Keck Center for Learning and Memory, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:52124-31. 2004
    ..Previous studies found that SV2A, but not SV2B, can interact with the cytoplasmic domain of synaptotagmin 1, a Ca2+ sensor for synaptic vesicle exocytosis...
  13. ncbi Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress
    M Landriscina
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 276:25549-57. 2001
    ..protein and Cu2+ is known to induce its dimerization, we evaluated the capacity of recombinant FGF1, p40 Syt1, and S100A13 to interact in a cell-free system and the role of Cu2+ in this interaction...
  14. ncbi Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
    K Ito
    Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    Mol Cell Biol 20:6891-903. 2000
    ..as a direct inhibitor of CREB binding protein (CBP)-associated HAT activity and also by recruiting HDAC2 to the p65-CBP HAT complex...
  15. ncbi p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex
    K Ito
    Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse St, London SW3 6LY, United Kingdom
    J Biol Chem 276:30208-15. 2001
    ..and granulocyte-macrophage colony-stimulating factor expression through a combination of direct inhibition of p65-associated histone acetyltransferase (HAT) activity and by recruiting histone deacetylase 2 (HDAC2) to the p65-HAT ..
  16. ncbi Effect of a synthetic lipid immunomodulator on the regulation of the transcription factor NF-kappaB
    S Pollet
    , La Tronche, France
    Immunopharmacol Immunotoxicol 22:653-69. 2000
    ..Antibodies to various NF-kappaB proteins supershifted p50, p65 and to a lesser extent c-rel...
  17. ncbi Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats
    Wei Guo Dong
    Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 9:2533-8. 2003
    ..To investigate the ameliorative effects of sodium ferulate (SF) on acetic acid-induced colitis and their mechanisms in rats...
  18. ncbi [Detection of cytomegalovirus (CMV) antigen for rapid diagnosis and monitoring of CMV diseases in AIDS]
    H Hanabusa
    Department of Pediatrics, Ogikubo Hospital
    Kansenshogaku Zasshi 68:1105-12. 1994
    ..leukocyte (CMV antigenemia), as it was determined with a monoclonal antibody against a lower matrix protein (p65); infectious CMV detected by shell vial method; CMV DNA detected by PCR; anti-CMV antibody titer; and histological ..
  19. ncbi [Research on the influence of diammonium glycyrrhizinate on the expression of NF-kappaB and neuron apoptosis after spinal cord ischemia-reperfusion injury in rats]
    Bingrui Liu
    Department of Clinical Medicine, Second Affiliated Hospital, Ningxia Medical University, Yinchuan Ningxia 750004, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:1466-9. 2008
    ..To investigate the influence of diammonium glycyrrhizinate (DG) on the expression of NF-kappaB and neuron apoptosis after spinal cord ischemia-reperfusion injury in rats...
  20. ncbi I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding
    P A Ganchi
    Gladstone Institute of Virology and Immunology, University of California, San Francisco
    Mol Biol Cell 3:1339-52. 1992
    ..nuclear form of the NF-kappa B transcription factor complex is composed of two DNA binding subunits, NF-kappa B p65 and NF-kappa B p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product...
  21. ncbi HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity
    Inbal Azran-Shaish
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, 84105, Israel
    J Mol Med (Berl) 86:799-814. 2008
    ..induce their dissociation from inhibitors of kappaB (IkappaB) and subsequent translocation to the nucleus where p65 links to the cyclic adenosine monophosphate response element binding protein (CBP)-p300 and P/CAF coactivators that ..
  22. ncbi [Effects of antisense oligonucleotide to nuclear factor-kappaB on the development of bleomycin-induced pulmonary fibrosis and IL-4 expression therein: experiment with mice]
    Xiao Ye Zhang
    Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China
    Zhonghua Yi Xue Za Zhi 87:195-9. 2007
    ....
  23. ncbi [The function of nuclear factor-erythroid 2-related factor 2 and its association with I-kappa B kinases alpha/beta in a rat model of chronic obstructive pulmonary disease.]
    Xiu Ying Li
    Respiratory Department of Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:935-9. 2009
    ..To study the expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the bronchial and lung tissues of chronic obstructive pulmonary disease (COPD) rat models and its association with I-kappa B kinases (IKKs)...
  24. ncbi [Evaluation of direct immunoperoxidase technique using F(ab')2 fractions of anti-cytomegalovirus human monoclonal antibody for enumeration of cytomegalovirus antigen-positive leukocytes]
    T Minematsu
    Department of Microbiology, Miyazaki Medical College
    Kansenshogaku Zasshi 68:1278-84. 1994
    Direct immunoperoxidase technique using human monoclonal antibody (C7) against a p65 antigen of cytomegalovirus (CMV) has been utilized to detect CMV antigen-positive leukocytes in the peripheral blood (CMV antigenemia)...
  25. ncbi [Effects of lanthanum on inhibition of lipopolysaccharide induced NF-kappaB activation]
    Fei Guo
    Burn Institute of Nanchang University, Nanchang 330006, P R China
    Zhonghua Shao Shang Za Zhi 23:117-21. 2007
    ..To investigate the influence of lanthanum on lipopolysaccharide (LPS) induced NF-KB activation in murine peritoneal macrophage...
  26. ncbi [Effects of hydrogen sulfide on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow: experiment with rats]
    Hong fang Jin
    Department of Pediatrics, Peking University First Hospital, Key Lab of Molecular Cardiovascular Medicine, Ministry of Education, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 88:2235-9. 2008
    ..To investigate the effects of hydrogen sulfide (H2S) on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow...
  27. ncbi Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription
    S K Hansen
    University Institute of Microbiology, Copenhagen, Denmark
    Mol Cell Biol 14:2593-603. 1994
    ..this activity from the HeLa cell cytosol and have shown that it represents a performed heteromeric complex between p65 (RelA) and c-Rel...
  28. ncbi [Effects of Lactobacilli on regulating NF-kappaB activation and IL-8 secretion in SGC7901 cell impacted by Helicobacter pylori]
    Feng Zhen Ma
    Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 38:795-8. 2007
    ..In vitro to investigate the regulation effects of Lactobacillus acidophilus ATCC4356 and L. bulgaricus (LB) on the activation of NF-kB and IL-8 secretion of SGC7901 cell, which Helicobacter pylori induced...
  29. ncbi The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases
    Baocun Sun
    Department of Pathology, Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China
    Cancer Sci 99:1355-61. 2008
    This study aimed to evaluate the diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma (SS) in known and potential cases...
  30. ncbi Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK
    Holger Buss
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 279:55633-43. 2004
    Phosphorylation of NF-kappaB p65(RelA) serine 536 is physiologically induced in response to a variety of proinflammatory stimuli, but the responsible pathways have not been conclusively unraveled, and the function of this phosphorylation ..
  31. ncbi Age- and experience-dependent expression of dynamin I and synaptotagmin I in cat visual system
    Lieselotte Cnops
    Laboratory of Neuroplasticity and Neuroproteomics, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Comp Neurol 504:254-64. 2007
    Dynamin I (Dyn I) and Synaptotagmin I (Syt I) are essential for endocytosis-exocytosis processes, thus for neurotransmission...
  32. ncbi Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy
    Angela Siciliano
    Dept of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Haematologica 96:24-32. 2011
    ..Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is only partially understood...
  33. ncbi Real-time polymerase chain reaction as an aid for the detection of SYT-SSX1 and SYT-SSX2 transcripts in fresh and archival pediatric synovial sarcoma specimens: report of 25 cases from St. Jude Children's Research Hospital
    D Ashley Hill
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Pediatr Dev Pathol 6:24-34. 2003
    ..children and adolescents and is characterized by a reciprocal t(X;18)(p11;q11) which results in the fusion of the SYT gene on chromosome 18q11 to either of two closely related genes, SSX1 (Xp11.23) or SSX2 (Xp11.21)...
  34. ncbi [Expression of NF-kappa B in human bladder cancer and its clinical significance]
    Dong Hua Xie
    Department of Urology, First People s Hospital of Shanghai, Shanghai 200080, P R China
    Ai Zheng 21:663-7. 2002
    ..This study was designed to investigate the expression differences of NF-kappa B and its regulated genes between human primary transitional cell carcinoma(TCCs) of bladder and non-cancer bladder mucosa and its clinical significance...
  35. ncbi Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
    C Kunsch
    Department of Gene Regulation, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    Mol Cell Biol 12:4412-21. 1992
    Analysis of the p50 and p65 subunits of the NF-kappa B transcription factor complex has revealed that both proteins can interact with related DNA sequences through either homo- or heterodimer formation...
  36. ncbi Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients
    Marc Ladanyi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:135-40. 2002
    ..They consistently show a specific t(X;18;p11;q11), which usually represents either of two gene fusions, SYT-SSX1 or SYT-SSX2, encoding putative transcriptional proteins differing at 13 amino acid positions...
  37. ncbi [Expression of NMBR in myometrium in pregnant mice at different gestational ages and its relation with parturition]
    Weishe Zhang
    Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 34:531-6. 2009
    ..To investigate the spatiotemporal expression of neuromedin B receptor (NMBR) in mice myometrium at different pregnant stages, as well as its mechanism and relation with parturition...
  38. ncbi Effect of forskolin on synaptotagmin IV protein trafficking in PC12 cells
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama
    J Biochem 136:245-53. 2004
    Synaptotagmin IV (Syt IV) was originally described as an immediate early gene product induced by forskolin or membrane depolarization in PC12 cells; however, nothing is known about the subcellular localization and transport of the newly ..
  39. ncbi Exchange of a nuclear corepressor between NF-kappaB and CREB mediates inhibition of phosphoenolpyruvate carboxykinase transcription by NF-kappaB
    Jin hua Yan
    Department of Endocrinology, Third Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510630, China
    Chin Med J (Engl) 123:221-6. 2010
    NF-kappaB p65 was shown to inhibit transcription of phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme in gluconeogenesis in the liver...
  40. ncbi A novel 65 kDa RNA-binding protein in squid presynaptic terminals
    D T P Lico
    Department of Cellular and Molecular Biology, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo 14049 900, Brazil
    Neuroscience 166:73-83. 2010
    ..antibody (C4), raised against the head domain of chicken myosin Va, reacted strongly towards a 65 kDa polypeptide (p65) on Western blots of extracts from squid optic lobes but did not recognize the heavy chain of squid myosin V...
  41. ncbi Synaptotagmin VII is targeted to dense-core vesicles and regulates their Ca2+ -dependent exocytosis in PC12 cells
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 279:52677-84. 2004
    It has recently been proposed that synaptotagmin (Syt) VII functions as a plasma membrane Ca2+ sensor for dense-core vesicle exocytosis in PC12 cells based on the results of transient overexpression studies using green fluorescent ..
  42. ncbi Effect of salvia miltiorrhizae on apoptosis and NF-kappaB p65 expression in the liver of rats with severe acute pancreatitis or obstructive jaundice
    Xiping Zhang
    Department of General Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    J Gastroenterol Hepatol 24:841-52. 2009
    ..To investigate the therapeutic effects and mechanism of salvia miltiorrhizae in the treatment of severe acute pancreatitis (SAP) or obstructive jaundice (OJ)...
  43. ncbi The proline-rich P65 protein of Mycoplasma pneumoniae is a component of the Triton X-100-insoluble fraction and exhibits size polymorphism in the strains M129 and FH
    T Proft
    Zentrum für Molekulare Biologie Heidelberg, Mikrobiologie, Universitat Heidelberg, Germany
    J Bacteriol 177:3370-8. 1995
    Previously, we described the identification of a novel Mycoplasma pneumoniae M129 protein, named P65 because of its apparent molecular mass of 65 kDa estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (T. Proft and R...
  44. ncbi Naturally occurring phenolic acids inhibit 12-O-tetradecanoylphorbol-13-acetate induced NF-kappaB, iNOS and COX-2 activation in mouse epidermis
    Michał Cichocki
    Poznan University of Medical Sciences, Department of Pharmaceutical Biochemistry, Swiecickiego 4, 60 781 Poznan, Poland
    Toxicology 268:118-24. 2010
    ..15min prior to TPA resulted in a significant decrease in the NF-kappaB activation which was measured in terms of p65-DNA binding...
  45. ncbi Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis
    Shufang Wu
    Section of Endocrinology and Diabetes, St Christopher s Hospital For Children, Department of Pediatrics, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134, USA
    J Biol Chem 282:33698-706. 2007
    ..we studied the effects of two NF-kappaB inhibitors (pyrrolidine dithiocarbamate (PDTC) or BAY11-7082 (BAY)), p65 short interference RNA (siRNA), and of the overexpression of p65 on chondrocyte proliferation, differentiation, and ..
  46. ncbi Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma
    Dafydd G Thomas
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
    Cancer 103:830-8. 2005
    ..The majority of synovial sarcomas harbor a specific chromosomal translocation in which the proximal portion of the SYT gene at chromosome 18q11 is fused to the distal portion of one of several duplicated SSX genes (most notably SSX1 ..
  47. ncbi Involvement of nuclear factor kappa B in the regulation of rat luteal function: potential roles as survival factor and inhibitor of 20alpha-hydroxysteroid dehydrogenase
    C M Telleria
    Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069, USA
    J Mol Endocrinol 32:365-83. 2004
    ..Western analysis and immunohistochemistry revealed that p65 and p50 were highly expressed throughout pregnancy and were located in both the nucleus and cytoplasm of luteal ..
  48. ncbi Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis
    Gautam Sethi
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Res 6:1059-70. 2008
    ..of the activation of I kappa B alpha kinase, I kappa B alpha phosphorylation, I kappa B alpha degradation, p65 phosphorylation, p65 nuclear translocation, and the NF-kappa B-dependent reporter gene expression...
  49. ncbi NFkappaB-p65 dependent transcriptional regulation of glycosyltransferases in human colon adenocarcinoma HT-29 by stimulation with tumor necrosis factor alpha
    Koji Higai
    Department of Clinical Chemistry, School of Pharmaceutical Sciences, Toho University, Chiba, Japan
    Biol Pharm Bull 29:2372-7. 2006
    ..and sialyltransferases (STs) in a human colon adenocarcinoma cell line HT-29 and nuclear factor kappaB (NFkappaB)-p65 knockdown HT-29 cells was investigated after stimulation with tumor necrosis factor alpha (TNFalpha) using real ..
  50. ncbi Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation
    Yun Dai
    Department of Medicine, Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia 23298, USA
    Mol Cell Biol 25:5429-44. 2005
    NF-kappaB activation is reciprocally regulated by RelA/p65 acetylation and deacetylation, which are mediated by histone acetyltransferases (HATs) and deacetylases (HDACs)...
  51. ncbi Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators
    M L Schmitz
    Institute of Biochemistry, Albert Ludwigs University, Freiburg, Federal Republic of Germany
    J Biol Chem 270:7219-26. 1995
    We show that the transactivating COOH terminus of the p65 subunit of human transcription factor NF-kappa B directly binds the general transcription factors TFIIB and TATA-binding protein (TBP) in vitro...
  52. ncbi Clinical impact of molecular and cytogenetic findings in synovial sarcoma
    I Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Genes Chromosomes Cancer 31:362-72. 2001
    ..This translocation results in rearrangements of the SYT gene in 18q11 and one of the SSX1, SSX2, or SSX4 genes in Xp11, creating a SYT/SSX1, SYT/SSX2, or SYT/SSX4 chimeric ..
  53. ncbi Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation
    Mourad Zerfaoui
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    J Immunol 185:1894-902. 2010
    ..In this study, we show that PARP-1 inhibition by gene knockout, knockdown, or pharmacologic blockade prevented p65 NF-kappaB nuclear translocation in smooth muscle cells upon TLR4 stimulation, NF-kappaB DNA-binding activity, and ..
  54. ncbi Increased plasma membrane localization of O-glycosylation-deficient mutant of synaptotagmin I in PC12 cells
    Eiko Kanno
    Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba ku, Sendai, Miyagi, Japan
    J Neurosci Res 86:1036-43. 2008
    Synaptotagmin I (Syt I) is a Ca2+-binding protein on synaptic vesicles and presumably functions as a Ca2+ sensor for neurotransmitter release...
  55. ncbi Hepatic preconditioning of doxorubicin in stop-flow chemotherapy: NF-kappaB/IkappaB-alpha pathway and expression of HSP72
    Hui Lu
    Shanghai Institute of Digestive Surgery, Rujin Hospital, Shanghai Second Medical University, Ruijin Road II, Shanghai 200025, China
    World J Gastroenterol 11:2136-41. 2005
    ..To provide hepatic protection through administration of doxorubicin before stop-flow chemotherapy (SFC) and to investigate the expression of heat shock protein 72 (HSP72) and role of nuclear factor kappa B (NF-kappaB) in this effect...
  56. ncbi Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation
    Susanne V Allander
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Pathol 161:1587-95. 2002
    ..It is characterized by a specific chromosomal translocation, t(X;18)(p11.2;q11.2), which juxtaposes the SYT gene on chromosome 18 to either the SSX1 or the SSX2 gene on chromosome X...
  57. ncbi Effect of phenol on the aggregation characteristics of an ethylene oxide-propylene oxide triblock copolymer P65 in aqueous solution
    J P Mata
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Colloid Interface Sci 320:275-82. 2008
    ..oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (PEO-PPO-PEO) amphiphilic copolymer (Pluronic P65: EO19 PO30 EO19) in aqueous solution have been studied by cloud point, viscosity, dynamic light scattering (DLS), ..
  58. ncbi Structure and self assembly of pluronic amphiphiles in ethylammonium nitrate and at the silica surface
    Rob Atkin
    Centre for Organic Electronics, The University of Newcastle, Callaghan, NSW, 2308, Australia, School of Chemistry, The University of Sydney, NSW, 2006, Australia, and Hahn Meitner Institute, Glienicker Str 100, 14109 Berlin, Germany
    J Phys Chem B 113:12201-13. 2009
    The self-assembled structures formed by three Pluronic surfactants (P65, L81, L121) in ethylammonium nitrate (EAN, a protic room temperature ionic liquid) in bulk solution and at the silica-EAN interface have been investigated using ..
  59. ncbi The Leishmania donovani lipophosphoglycan excludes the vesicular proton-ATPase from phagosomes by impairing the recruitment of synaptotagmin V
    Adrien F Vinet
    INRS Institut Armand Frappier and Centre for host parasite interactions, Laval, Quebec, Canada
    PLoS Pathog 5:e1000628. 2009
    We recently showed that the exocytosis regulator Synaptotagmin (Syt) V is recruited to the nascent phagosome and remains associated throughout the maturation process...
  60. ncbi Differential distribution of synaptotagmin-1, -4, -7, and -9 in rat adrenal chromaffin cells
    Hidetada Matsuoka
    Department of Cell and Systems Physiology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, 807 8555, Japan
    Cell Tissue Res 344:41-50. 2011
    ..The present work was undertaken to identify the synaptotagmin (Syt) isoforms present in secretory vesicles...
  61. ncbi Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding
    Jing Hu
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Building 567, Room 188, Frederick, MD 21702, USA
    Mol Cancer Res 3:100-9. 2005
    ..Electrophoretic mobility shift assay studies showed that trichostatin A treatment prevents p65 dimer binding to NF-kappaB sites on DNA...
  62. ncbi Nuclear factor kappa B: a marker of chemotherapy for human stage IV gastric carcinoma
    You Ming Long
    Clinical College, Guangdong Pharmaceutical University, and Carcinoma Department, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou 510080, Guangdong Province, China
    World J Gastroenterol 14:4739-44. 2008
    ..To detect the nuclear factor kappa B (NF-kappaB) condition in human stage IV gastric carcinoma patients and to explore the correlation between NF-kappaB activation and survival of these patients after chemotherapy...
  63. ncbi Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration
    Taichi Kimura
    Laboratory of Molecular and Cellular Pathology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Lab Invest 89:645-56. 2009
    b>SYT-SSX protein, resulted from chromosomal translocation, causes synovial sarcoma, which is a malignant tumor accounting for 10% of soft tissue sarcoma...
  64. ncbi Expression of SODD and P65 in ALL of children and its relationship with chemotherapeutic drugs
    Hongfang Tao
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 27:326-9. 2007
    ..expression of silence of death domains (SODD) and its clinical significance and relationship with phospho-NF-kappaB-p65 proteins in bone marrow cells of childhood acute lymphoblastic leukaemia (ALL) were explored, and the expression of ..
  65. ncbi Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101
    Jianming Duan
    National Institute on Deafness and Other Communication Disorders, NIH, CRC Building 10, Room 4 2732, 10 Center Drive, Bethesda, MD 20892, USA
    Mol Cancer Ther 6:37-50. 2007
    ..HNSCC), in which we have shown the activation of nuclear factor-kappaB (NF-kappaB; NF-kappaB1/RelA or p50/p65), a transcription factor that promotes expression of proliferative and antiapoptotic genes...
  66. ncbi Vesicle-associated membrane protein-2/synaptobrevin binding to synaptotagmin I promotes O-glycosylation of synaptotagmin I
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 277:30351-8. 2002
    Synaptotagmin I (Syt I), an evolutionarily conserved integral membrane protein of synaptic vesicles, is now known to regulate Ca2+-dependent neurotransmitter release...
  67. ncbi Roles of SNARE proteins and synaptotagmin I in synaptic transmission: studies at the Drosophila neuromuscular synapse
    Yoshi Kidokoro
    Institute for Behavioral Sciences, Gunma University School of Medicine, Maebashi, Japan
    Neurosignals 12:13-30. 2003
    ..e. neuronal Synaptobrevin (n-Syb), SNAP-25 and Syntaxin 1A (Syx 1A), and Synaptotagmin I (Syt I) in synaptic transmission have been studied in situ using mutant embryos or larvae that lack these molecules or ..
  68. ncbi The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type)
    Roy Cohen
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Biol Chem 278:9258-66. 2003
    Biochemical and genetic studies implicate synaptotagmin (Syt 1) as a Ca2+ sensor for neuronal and neuroendocrine neurosecretion. Calcium binding to Syt 1 occurs through two cytoplasmic repeats termed the C2A and C2B domains...
  69. ncbi Activation of the serum response factor by p65/NF-kappaB
    G Franzoso
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 15:3403-12. 1996
    This study demonstrates that the NF-kappaB subunit p65 can act like an accessory protein for the serum response factor (SRF) in transfection assays...
  70. ncbi The effect of SYT-SSX and extracellular signal-regulated kinase (ERK) on cell proliferation in synovial sarcoma
    Wenjuan Cai
    Department of Pathology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People s Republic of China
    Pathol Oncol Res 17:357-67. 2011
    ..2;q11.2), which results in the fusion of the SYT gene with a SSX gene...
  71. ncbi Increased expression of NF-kappa B subunits in human pancreatic cancer cells
    Nicole M Chandler
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA, USA
    J Surg Res 118:9-14. 2004
    ..We compared the relative expression of NF-kappa B subunits with nuclear activation of p65 between variably differentiated pancreatic cancer cells.
  72. ncbi Synaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblasts
    I Martinez
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cell Biol 148:1141-49. 2000
    Synaptotagmins (Syts) are transmembrane proteins with two Ca(2+)-binding C(2) domains in their cytosolic region. Syt I, the most widely studied isoform, has been proposed to function as a Ca(2+) sensor in synaptic vesicle exocytosis...
  73. ncbi [Relationship between glomerular lesion and NF-kappaB p65 activity in rat multiple organ failure caused by zymosan]
    Xue mei Chen
    Department of Emergency, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 21:486-8, 492. 2005
    To observe the relationship between NF-kappaB p65 activity and glomerular lesion in rat multiple organ failure (MOF) caused by zymosan.
  74. ncbi [Effect of activation of nuclear factor-KappaB on modulation of secretion of intercellular adhesion molecule-1 by A549 cell]
    Pin hu Liao
    Coronary Care Unit, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:151-4. 2009
    ..To investigate the effects of interleukin-1beta (IL-1beta) on intercellular adhesion molecule-1 (ICAM-1) expression on A549 cell and underlying signal transduction pathways...
  75. ncbi Differential expression and function of synaptotagmin 1 isoforms in Caenorhabditis elegans
    Eleanor A Mathews
    Program in Molecular, Cell and Developmental Biology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Mol Cell Neurosci 34:642-52. 2007
    b>Synaptotagmin 1, encoded by the snt-1 gene in Caenorhabditis elegans, is a major synaptic vesicle protein containing two Ca(2+)-binding (C2) domains...
  76. ncbi Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB
    Suparna Qanungo
    Department of Anatomy, Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 282:18427-36. 2007
    ..and Nieminen, A. L. (2004) J. Biol. Chem. 279, 50455-50464). Here, we examined sulfhydryl modifications of the p65 subunit of NFkappaB that are responsible for NFkappaB inactivation...
  77. ncbi Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells
    Kazuo Hayakawa
    Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 432:713-9. 2013
    ..2; q11.2), which produces SS-specific fusion gene, SYT-SSX...
  78. ncbi The N Terminus of Orf Virus-Encoded Protein 002 Inhibits Acetylation of NF-κB p65 by Preventing Ser(276) Phosphorylation
    Zhangyong Ning
    College of Veterinary Medicine, South China Agricultural University, Guangzhou, People s Republic of China
    PLoS ONE 8:e58854. 2013
    Orf virus-encoded protein 002 (ORFV002) inhibits NF-κB signaling pathway by decreasing the acetylation of NF-κB-p65 through interference of NF-κB p65's association with NF-κB p300...
  79. ncbi NF-κB-associated mechanisms underlying the response of embryonic cells to Doxorubicin
    S Savion
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Toxicol In Vitro 27:804-11. 2013
    ..Therefore, we tried to assess the involvement of the p65 subunit of NF-κB in the embryonic response to the anti-cancer drug Doxorubicin (DOX)...
  80. ncbi Site-specific phosphorylation of the p65 protein subunit mediates selective gene expression by differential NF-κB and RNA polymerase II promoter recruitment
    Karin Hochrainer
    Department of Neurology and Neuroscience, Division of Neurobiology, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 288:285-93. 2013
    ..For the p65 subunit, multiple phosphorylation sites have been mapped in and adjacent to both the N-terminal Rel homology domain ..
  81. ncbi Immunohistochemical profile of NF-κB/p50, NF-κB/p65, MMP-9, MMP-2, and u-PA in experimental cervical spondylotic myelopathy
    Spyridon K Karadimas
    Department of Neurosurgery, University Hospital of Patras, Rio Patras, Greece
    Spine (Phila Pa 1976) 38:4-10. 2013
    The immunohistochemical profile of nuclear factor-κ B (NF-κB)/p50, NF-κB/p65, matrix metalloproteinase (MMP)-9, MMP-2, and urokinase-type plasminogen activator (u-PA) proteins was examined in spinal cord tissues coming from rabbits, ..
  82. ncbi Asbestos causes translocation of p65 protein and increases NF-kappa B DNA binding activity in rat lung epithelial and pleural mesothelial cells
    Y M Janssen
    Department of Pathology, University of Vermont, Burlington, USA
    Am J Pathol 151:389-401. 1997
    ..models of crocidolite- and chrysotile-induced inflammation and asbestosis were used to study the localization of p65, a protein subunit of the NF-kappa B transcription factor, in sham control rats and those exposed to asbestos...
  83. ncbi A novel type of SYT/SSX fusion: methodological and biological implications
    Maria Törnkvist
    Department of Cellular and Molecular Tumor Pathology, Cancer Centrum Karolinska, Karolinska Hospital, Stockholm, Sweden
    Mod Pathol 15:679-85. 2002
    ..It is characterized by the chromosomal translocation t(X;18)(p11.2;q11.2), which results in the fusion of the SYT gene on chromosome 18 with a SSX gene on chromosome X...
  84. ncbi New molecular bridge between RelA/p65 and NF-κB target genes via histone acetyltransferase TIP60 cofactor
    Jung Woong Kim
    From the School of Biological Sciences, Chung Ang University, Seoul 156 756, South Korea
    J Biol Chem 287:7780-91. 2012
    ..We also found that TIP60 interacts with the NF-κB RelA/p65 subunit and increases its transcriptional activity through protein-protein interaction...
  85. ncbi Homeostatic regulatory role of Pokemon in NF-κB signaling: stimulating both p65 and IκBα expression in human hepatocellular carcinoma cells
    Nan Nan Zhang
    Department of Chemistry, Tsinghua University, Beijing 100084, People s Republic of China
    Mol Cell Biochem 372:57-64. 2013
    NF-κB consists of p50, p65 (RelA), p52, c-Rel, and RelB, and among them p65 is a representative protein to investigate the regulation and function of this signaling...
  86. ncbi Synaptotagmin1 is required for spindle stability and metaphase-to-anaphase transition in mouse oocytes
    Xiu Lan Zhu
    Center for Reproductive Medicine, Department of Ob Gy, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China
    Cell Cycle 11:818-26. 2012
    ..Here, we identified the unique localization, expression and function of Syt1 during mouse oocyte meiotic maturation by using confocal microscopy, western blotting, Morpholino-based knockdown ..
  87. ncbi De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy
    Fadi F Hamdan
    Centre of Excellence in Neuromics of Université de Montréal and Synapse to Disease Group, Centre Hospitalier Universitaire Sainte Justine Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Ann Neurol 65:748-53. 2009
    ..coding for components of the SNARE complex (STX1A, VAMP2, SNAP25) and their regulatory proteins (STXBP1/Munc18-1, SYT1), which are essential for neurotransmission, in 95 patients with idiopathic mental retardation...
  88. ncbi The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits
    D B Huang
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0359, USA
    Structure 5:1427-36. 1997
    ..Crystal structures of the rel/NFkappaB family members p50 and p65 in their DNA-bound homodimeric form have been solved...
  89. ncbi Genomic structures of synaptotagmin II protein: comparison of exon-intron organization of the synaptotagmin gene family
    M Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    Biochem Biophys Res Commun 270:528-32. 2000
    Synaptotagmin (Syt) I (or II) is thought to be a Ca(2+) sensor for neurotransmitter release in the rostral (or caudal) region of the mammalian brain...
  90. ncbi NF-kappaB p65 antisense oligonucleotides may serve as a novel molecular approach for the treatment of patients with ulcerative colitis
    Zhi Li
    Department of Gastroenterology and Geriatric Medicine West China Hospital, Sichuan University, Chengdu, China
    Arch Med Res 39:729-34. 2008
    ..The aim of this study was to investigate if NF-kappaB p65 antisense oligonucleotides may affect the expression of NF-kappaB p65 and cytokines in lamina propria mononuclear ..
  91. ncbi Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis
    Jon D Gaffaney
    Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 283:31763-75. 2008
    Synaptotagmin (syt) 1 is localized to synaptic vesicles, binds Ca2+, and regulates neuronal exocytosis. Syt 1 harbors two Ca2+-binding motifs referred to as C2A and C2B...
  92. ncbi Intermittent L-DOPA treatment differentially alters synaptotagmin 4 and 7 gene expression in the striatum of hemiparkinsonian rats
    Gordana Glavan
    Brain Research Laboratory, Institute for Pathophysiology, Medical Faculty, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Brain Res 1236:216-24. 2008
    ..We have previously reported that acute L-DOPA treatment upregulated the expression of Syt 4 and Syt 7 mRNAs in hypersensitive striatum of 6-OHDA rat model for PD...
  93. ncbi The N-terminal half of the heavy chain of botulinum type A neurotoxin forms channels in planar phospholipid bilayers
    R O Blaustein
    Department of Physiology, Albert Einstein College of Medicine, Bronx, NY 10461
    FEBS Lett 226:115-20. 1987
    ..These findings are strikingly similar to those previously reported for analogous fragments of diphtheria and tetanus toxins...
  94. ncbi G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes
    Fui Goon Goh
    Strathclyde Institute of Pharmacy and Biomedical Sciences, Division of Physiology and Pharmacology, University of Strathclyde, 27 Taylor Street, Glasgow, G4 0NR, Scotland, UK
    Cell Signal 20:1267-74. 2008
    The mechanisms underpinning the coupling of GPCRs, such as PAR-2, to the phosphorylation of p65 NFkappaB have not been investigated...
  95. ncbi Dissociated invasively growing cancer cells with NF-kappaB/p65 positivity after radiotherapy: a new marker for worse clinical outcome in rectal cancer? Preliminary data
    Rene Voboril
    Department of Surgery, Charles University 3rd Faculty of Medicine and Teaching Hospital Kralovske Vinohrady, Prague 10, Czech Republic
    Clin Exp Metastasis 25:491-6. 2008
    Objectives Nuclear factor-kappaB (NF-kappaB), especially p65 subunit, seems to be associated with origin and progression of cancer...
  96. ncbi [NF-kappaB subunit p65/RelA expression in ovarian carcinoma: prognostic impact and link to COX-2 overexpression]
    S Niesporek
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Campus Mitte
    Verh Dtsch Ges Pathol 91:243-9. 2007
    ..To add translational information on the situation in vivo, we determined the expression pattern of p65, an important subunit of the classic NF-kappaB pathway, in ovarian carcinoma tissue, and investigated in vivo and ..
  97. ncbi Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells
    Jean Sébastien Schonn
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 105:3998-4003. 2008
    ....
  98. ncbi Induction of p21 by p65 in p53 null cells treated with Doxorubicin
    Shenglin Ma
    Zhejiang Tumor Hospital, Banshanqiao, Hangzhou, Zhejiang Province, China
    Biochim Biophys Acta 1783:935-40. 2008
    NFkappaB/p65 is a transcription factor that can protect or contribute to cell death...
  99. ncbi Aging-dependent upregulation of IL-23p19 gene expression in dendritic cells is associated with differential transcription factor binding and histone modifications
    Rabab El Mezayen
    Section of Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Aging Cell 8:553-65. 2009
    ..Expression of the p19 subunit is regulated at the transcriptional level by NF-kappaB p65 and c-Rel transcription factors...
  100. ncbi Cytosolic SYT/SS18 isoforms are actin-associated proteins that function in matrix-specific adhesion
    JaeHong Kim
    Center for Lung Biology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e6455. 2009
    b>SYT (SYnovial sarcoma Translocated gene or SS18) is widely produced as two isoforms, SYT/L and SYT/S, that are thought to function in the nucleus as transcriptional coactivators...
  101. ncbi Transcription factor NF-κB (p50/p50, p65/p65) controls porcine ovarian cells functions
    Silvia Pavlová
    Constantine The Philosopher University in Nitra, Nitra, Slovakia
    Anim Reprod Sci 128:73-84. 2011
    The aim of these in vitro studies was to examine the involvement of transcription factor NF-κB (p50/p50, p65/p65) and FSH in control of porcine ovarian granulosa cells functions and the possible role of dimers p50/p50, p65/p65 in ..

Research Grants98

  1. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2001
    ..In contrast with enhanced nuclear translocation of the activating p65/p50 NF-kB heterodimer following LPS stimulation, the investigator's preliminary data show that acute alcohol ..
  2. Regulated Exocytosis of Lysosomes
    Norma Andrews; Fiscal Year: 2007
    ..Our previous studies identified the Ca2+-sensing lysosomal protein synaptotagmin VII (Syt VII) as a key regulator of this process, and defined the components of Syt VII- interacting SNARE complexes ..
  3. Regulated Exocytosis of Lysosomes
    Norma Andrews; Fiscal Year: 2009
    ..Our previous studies identified the Ca2+-sensing lysosomal protein synaptotagmin VII (Syt VII) as a key regulator of this process, and defined the components of Syt VII- interacting SNARE complexes ..
  4. Targeting the NF-kappaB Pathway in Melanoma
    Ann Richmond; Fiscal Year: 2009
    ..of IKK, enhanced phosphorylation and degradation of IkappaB, and elevated levels of activated the NF-kappaB p65/p50 complex in the nucleus...
  5. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
    ..with an inhibitory protein known as IkappaB and another mechanism involves direct phosphorylation of the p65 subunit of NF-kappaB which controls transactivation potential...
  6. Cell Adhesion Control by the Proto-Oncoprotein SYT
    JOSIANE EID; Fiscal Year: 2005
    ..It is characterized by a chromosomal rearrangement between the SYT gene on chromosome 18 and the SSX gene on chromosome x, which results in a fusion product, SYT/SSX...
  7. B-Catenin regulation by the Proto-Oncoprotein SYT
    JOSIANE EID; Fiscal Year: 2007
    ..It is characterized by a chromosomal translocation t(X; 18;pl 1;ql 1) that juxtaposes the SYT gene on chromosome 18 and the SSX gene on the X chromosome, resulting in the fusion, SYT-SSX...
  8. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2007
    ..Our recent studies (Neoplasia Vol.6 No.4, 2004) have shown that NF-kappaB/p65 is constitutively activated in human prostate adenocarcinoma and correlates with disease progression...
  9. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2009
    ..Our recent studies (Neoplasia Vol.6 No.4, 2004) have shown that NF-kappaB/p65 is constitutively activated in human prostate adenocarcinoma and correlates with disease progression...
  10. ROLE FOR NF-KAPPA B IN RAS-MEDIATED ONCOGENESIS
    ALBERT BALDWIN JR; Fiscal Year: 2002
    ..Consistent with this observation, we find that the transcriptional activation function of the RelA/p65 subunit of NF-kappaB (existing in relatively low nuclear levels) is functionally activated in Ras or Raf ..
  11. Role of NF-kappaB phosphorylation in inflammatory signaling
    Josef Anrather; Fiscal Year: 2007
    ..Specifically, phosphorylation of the NF-KappaB p65 subunit has been implicated as an important step in achieving target gene expression by facilitating promoter ..
  12. Unexpected Nucleosomal Functions for the IKKs
    ALBERT BALDWIN JR; Fiscal Year: 2007
    ..growth factor (EGF)-induced histone H3 ser10 phosphorylation and that GSK-3beta controls the phosphorylation of the p65 subunit on ser536...
  13. Role of IKK in NSCLC Modulation of SMRT and NF-kappab
    MARTY MAYO; Fiscal Year: 2007
    ..However, to achieve full NF-KappaB transcriptional activity, IKKalpha must also phosphorylate RelA/p65 within its transactivation domain...
  14. Tat Transactivation
    BORIS MATIJA PETERLIN; Fiscal Year: 2010
    ..P-TEFb contains the Cyclin dependent kinase 9 (Cdk9) and a C-type cyclin, CycT1, CycT2 or CycK. NF-KB contains p65 (RelA) and p50...
  15. Tat Transactivation
    B Matija Peterlin; Fiscal Year: 2007
    ..P-TEFb contains the Cyclin dependent kinase 9 (Cdk9) and a C-type cyclin, CycT1, CycT2 or CycK. NF-KB contains p65 (RelA) and p50...
  16. NF-kB SUBUNITS p65 AND RelB IN OSTEOCLASTS
    Deborah Novack; Fiscal Year: 2007
    ..There are 5 subunits in the NF-kappaB family (p65, RelB, c-rel, p50, and p52) each bearing the DNA-binding Rel homology domain, and transcription is mediated by homo-..
  17. NF-kB SUBUNITS p65 AND RelB IN OSTEOCLASTS
    Deborah Novack; Fiscal Year: 2009
    ..There are 5 subunits in the NF-kappaB family (p65, RelB, c-rel, p50, and p52) each bearing the DNA-binding Rel homology domain, and transcription is mediated by homo-..
  18. Regulation of NF-kB transcriptional activity
    Sankar Ghosh; Fiscal Year: 2007
    ..However, studies carried out in our laboratory have demonstrated that the p65 subunit of NF-kappaB has to be phosphorylated to become competent for transcription...
  19. Regulation of NF-kB transcriptional activity
    Sankar Ghosh; Fiscal Year: 2009
    ..However, studies carried out in our laboratory have demonstrated that the p65 subunit of NF-kappaB has to be phosphorylated to become competent for transcription...
  20. Intestinal Microbiota, Diet and Risk of Colorectal Adenomas
    Robert S Sandler; Fiscal Year: 2010
    ..IL-4, IL-17, INF(, IL-8, IL-10 and TGF-(;macrophages, NK cells, T cells- CD4+ and CD8+;protein expression of NF-(B (p65) and STAT3) among subjects with and without adenomas, 3) assess the association between adherent bacteria profiles ..
  21. Intestinal Microbiota, Diet and Risk of Colorectal Adenomas
    Temitope Keku; Fiscal Year: 2009
    ..IL-17, INF(, IL-8, IL-10 and TGF-(; macrophages, NK cells, T cells- CD4+ and CD8+; protein expression of NF-(B (p65) and STAT3) among subjects with and without adenomas, 3) assess the association between adherent bacteria profiles ..
  22. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2010
    ..Aim 2 will determine the role of p65 as an activator or repressor of polycomb-mediated gene expression...
  23. NEUROTROPHIC FACTOR AND NEURONAL PRIMARY RESPONSE GENES
    Harvey Herschman; Fiscal Year: 2000
    ..Syt4 is induced in the hippocampus and the piriform cortex following kainic acid induced seizures. In contrast, Syt1 is not inducible in PC12 cells or brain...
  24. Synaptotagmin function in virus movement and plant development
    SONDRA LAZAROWITZ; Fiscal Year: 2007
    ..SYTA is 1 of 5 Arabidopsis synaptotagmins (SYT A-E)...
  25. Synaptotagmin function in virus movement and plant development
    Sondra G Lazarowitz; Fiscal Year: 2010
    ..SYTA is 1 of 5 Arabidopsis synaptotagmins (SYT A-E)...
  26. INDUCTION OF ACUTE PHASE PROTEIN BIOSYNTHESIS
    David Samols; Fiscal Year: 2004
    ..findings did not reflect classic NFkappaB activity; 1) CRP expression was inhibited by over-expressed pp65 and 2) p65 was not found in EMSA complexes...
  27. Regulated Exocytosis of Lysosomes
    NORMA WINDSOR ANDREWS; Fiscal Year: 2010
    ..Our previous studies identified the Ca2+-sensing lysosomal protein synaptotagmin VII (Syt VII) as a key regulator of this process, and defined the components of Syt VII- interacting SNARE complexes ..
  28. Mechanisms of cigarette smoke-induced chromatin remodeling in lung inflammation
    Irfan Rahman; Fiscal Year: 2010
    ..that CS activates I(B-kinase (IKK)-1 and causes increased histone acetylation as well as acetylation of the RelA/p65 subunit of NF(B in primary human small airway epithelial cells (SAEC) and in mouse lung leading to increased levels ..
  29. Mechanisms of cigarette smoke-induced chromatin remodeling in lung inflammation
    Irfan Rahman; Fiscal Year: 2007
    ..that CS activates I(B-kinase (IKK)-1 and causes increased histone acetylation as well as acetylation of the RelA/p65 subunit of NF(B in primary human small airway epithelial cells (SAEC) and in mouse lung leading to increased levels ..
  30. Role of NF-kB in hematopoietic stem cells and leukemia-initiating cell formation
    Christopher A Klug; Fiscal Year: 2010
    Constitutive activation of the classical NF-?B pathway, which principally involves RelA/p65, c-Rel, and p50, has been observed in human acute myeloid leukemia (AML) where constitutive NF-?B DNA-binding activity has been detected in ..
  31. REGULATION OF INTERFERON-INDUCED DSRNA-ACTIVATED KINASE
    Bryan Williams; Fiscal Year: 1993
    ..We have cloned and characterized the human p68 and mouse p65 kinases and expressed the cDNAs in E.coli, yeast and mammalian cells...
  32. Regulation of Type 2 NF-kappaB Activation and Inflammation
    Genhong Cheng; Fiscal Year: 2009
    ..The NF-kB transcription factors, including p50, p52, p65, c-Rel and Rel-B, are critical regulators of inflammation, proliferation and apoptosis...
  33. Regulation of Type 2 NF-kappaB Activation and Inflammation
    Genhong Cheng; Fiscal Year: 2010
    ..The NF-kB transcription factors, including p50, p52, p65, c-Rel and Rel-B, are critical regulators of inflammation, proliferation and apoptosis...
  34. Homologous Recombination in a Secretory Mouse Cell Line
    AMY HARKINS; Fiscal Year: 2003
    ..Synaptotagmin I (syt I), an integral vesicular protein, has been postulated to act as the Ca2+ sensor for exocytosis...
  35. Mechanisms of Coronary Arteriolar Dysfunction in Type 2 Diabetes
    Khalid Matrougui; Fiscal Year: 2010
    ..Our preliminary data indicate an increase in oxidative stress (superoxide;O2.-), p65- NFkB activity and PARP-1 activity in coronary arterioles from db-/db- mice...
  36. Molecular Pathways Regulating Airway Goblet Cell Mucin Secretion
    Burton F Dickey; Fiscal Year: 2010
    ..second messengers are the Munc13 priming proteins that bind DAG and Ca2+, and the SNARE-triggering Synaptotagmin (Syt) proteins that bind phospholipids and Ca2+...
  37. Regulation of Endothelial ICAM-1 and PMN-Mediated Lung Injury by Actin Dynamics
    Fabeha Fazal; Fiscal Year: 2010
    ..The basis of ICAM-1 expression involves activation of RelA/p65 subunit of the transcription factor NF-(B...
  38. Synaptotagmin and C2-Domains: Structure and Function
    JOSE RIZO REY; Fiscal Year: 2009
    ..Moreover, since many neurological disorders are treated with drugs that alter synaptic transmission, this research is expected to provide crucial clues for the development of novel strategies to understand and treat these disorders. ..
  39. Synaptotagmin and C2-Domains: Structure and Function
    JOSE RIZO REY; Fiscal Year: 2010
    ..Moreover, since many neurological disorders are treated with drugs that alter synaptic transmission, this research is expected to provide crucial clues for the development of novel strategies to understand and treat these disorders. ..
  40. Release of FGF1 and the Pathology of Angiogenesis
    Igor Prudovsky; Fiscal Year: 2004
    ..complex which includes the extravesicular domain (p40) of the exocytotic trafficking-protein, p65 synaptotagmin (Syt1) and the annexin (Anx)2-binding protein, S100A13...
  41. Release of FGF1 and the Pathology of Angiogenesis
    Thomas Maciag; Fiscal Year: 2002
    ..complex which includes the extravesicular domain (p40) of the exocytotic trafficking-protein, p65 synaptotagmin (Syt1) and the annexin (Anx)2-binding protein, S100A13...