syndecan

Summary

Gene Symbol: syndecan
Description: syndecan 1
Alias: CD138, SDC, SYND1, syndecan, syndecan-1, CD138 antigen, heparan sulfate proteoglycan fibroblast growth factor receptor, syndecan proteoglycan 1
Species: human
Products:     syndecan

Top Publications

  1. Multhaupt H, Yoneda A, Whiteford J, Oh E, Lee W, Couchman J. Syndecan signaling: when, where and why?. J Physiol Pharmacol. 2009;60 Suppl 4:31-8 pubmed
    ..Syndecans are the only family of transmembrane heparan sulphate proteoglycans. Invertebrates all appear to have one Syndecan core protein, but in mammals there are four...
  2. de Parseval A, Bobardt M, Chatterji A, Chatterji U, Elder J, David G, et al. A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs. J Biol Chem. 2005;280:39493-504 pubmed
    ..In this study, we investigated at a molecular level the mechanisms that control HIV-1-syndecan interactions...
  3. Rapraeger A, Ell B, Roy M, Li X, Morrison O, Thomas G, et al. Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between ?V?3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesi. FEBS J. 2013;280:2194-206 pubmed publisher
    ..growth factor-1 receptor (IGF1R) kinase, into a ternary receptor complex organized by the matrix receptor syndecan-1 (Sdc1), we questioned the role of this core complex in VEGF-stimulated angiogenesis...
  4. Molica S, Vitelli G, Mirabelli R, Digiesu G, Giannarelli D, Cuneo A, et al. Serum levels of syndecan-1 in B-cell chronic lymphocytic leukemia: correlation with the extent of angiogenesis and disease-progression risk in early disease. Leuk Lymphoma. 2006;47:1034-40 pubmed
    b>Syndecan-1 is a transmembrane proteoglycan generally not expressed in mature B-cell neoplasias like chronic lymphocytic leukemia (CLL). Moreover, information dealing with the evaluation of soluble syndecan-1 in CLL are lacking...
  5. Mukunyadzi P, Liu K, Hanna E, Suen J, Fan C. Induced expression of syndecan-1 in the stroma of head and neck squamous cell carcinoma. Mod Pathol. 2003;16:796-801 pubmed
    b>Syndecan-1 (CD138), a cell-surface heparan sulfate proteoglycan, is involved in cell-cell, cell-matrix interaction and growth factor binding...
  6. Shimada K, Nakamura M, De Velasco M, Tanaka M, Ouji Y, Miyake M, et al. Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma. Cancer Sci. 2010;101:155-60 pubmed publisher
    Heparan sulfate proteoglycan syndecan-1, CD138, is well known to be associated with cell proliferation, adhesion, and migration in various types of malignancies...
  7. KLIMENT C, Englert J, Gochuico B, Yu G, Kaminski N, Rosas I, et al. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. J Biol Chem. 2009;284:3537-45 pubmed publisher
    ..This study investigates how extracellular superoxide dismutase (EC-SOD), a syndecan-binding antioxidant enzyme, inhibits inflammation and lung fibrosis...
  8. Kainulainen V, Wang H, Schick C, Bernfield M. Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids. J Biol Chem. 1998;273:11563-9 pubmed
    ..b>Syndecan-1 and syndecan-4 ectodomains are shed into acute human dermal wound fluids (Subramanian, S. V., Fitzgerald, M. L...
  9. Leivonen M, Lundin J, Nordling S, von Boguslawski K, Haglund C. Prognostic value of syndecan-1 expression in breast cancer. Oncology. 2004;67:11-8 pubmed
    b>Syndecan-1 is a cell surface heparan sulphate proteoglycan which participates in cell proliferation, cell migration and cell-matrix interactions...

More Information

Publications73

  1. Zong F, Fthenou E, Wolmer N, Hollosi P, Kovalszky I, Szilak L, et al. Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells. PLoS ONE. 2009;4:e7346 pubmed publisher
    b>Syndecan-1 forms complexes with growth factors and their cognate receptors in the cell membrane. We have previously reported a tubulin-mediated translocation of syndecan-1 to the nucleus...
  2. Ding K, Lopez Burks M, Sánchez Duran J, Korc M, Lander A. Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells. J Cell Biol. 2005;171:729-38 pubmed
    ..We sought to explain why the cell surface HSPG syndecan-1, which is also up-regulated by these cells and is a known growth factor coreceptor, does not compensate for ..
  3. Szatmári T, Mundt F, Heidari Hamedani G, Zong F, Ferolla E, Alexeyenko A, et al. Novel genes and pathways modulated by syndecan-1: implications for the proliferation and cell-cycle regulation of malignant mesothelioma cells. PLoS ONE. 2012;7:e48091 pubmed publisher
    ..In mesothelioma the expression of syndecan-1 correlates to epithelioid morphology and inhibition of growth and migration...
  4. Ledezma R, Cifuentes F, Gallegos I, Fullá J, Ossandon E, Castellon E, et al. Altered expression patterns of syndecan-1 and -2 predict biochemical recurrence in prostate cancer. Asian J Androl. 2011;13:476-80 pubmed publisher
    ..Our aim was to assess the value of altered expression of syndecan-1 and -2 as a marker for predicting biochemical relapse in patients with clinically localized prostate cancer ..
  5. Lundstrom E, Sahlin L, Skoog L, Hägerström T, Svane G, Azavedo E, et al. Expression of Syndecan-1 in histologically normal breast tissue from postmenopausal women with breast cancer according to mammographic density. Climacteric. 2006;9:277-82 pubmed
    To analyze the expression of Syndecan-1 in dense and non-dense human breast tissue. Specimens of histologically normal tissue were obtained from postmenopausal women undergoing surgery for breast cancer...
  6. Shi Q, Jiang J, Luo G. Syndecan-1 serves as the major receptor for attachment of hepatitis C virus to the surfaces of hepatocytes. J Virol. 2013;87:6866-75 pubmed publisher
    ..Collectively, our findings demonstrate that SDC1 serves as the major receptor protein for HCV attachment to cells, providing another potential target for discovery and development of antiviral drugs against HCV...
  7. Derksen P, Keehnen R, Evers L, van Oers M, Spaargaren M, Pals S. Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma. Blood. 2002;99:1405-10 pubmed
    ..Within the immune system, expression of the HSPG syndecan-1 (CD138) is characteristic of terminally differentiated B cells, ie, plasma cells, and their malignant ..
  8. Altemeier W, Schlesinger S, Buell C, Brauer R, Rapraeger A, Parks W, et al. Transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion. J Biol Chem. 2012;287:34927-35 pubmed publisher
    b>Syndecan-1 is a cell surface proteoglycan that can organize co-receptors into a multimeric complex to transduce intracellular signals...
  9. Lundin M, Nordling S, Lundin J, Isola J, Wiksten J, Haglund C. Epithelial syndecan-1 expression is associated with stage and grade in colorectal cancer. Oncology. 2005;68:306-13 pubmed
    Loss of epithelial heparan sulfate proteoglycan syndecan-1 has been associated with a more aggressive behavior in various cancer forms, but the prognostic significance of syndecan-1 expression in colorectal cancer is unclear...
  10. Maeda T, Desouky J, Friedl A. Syndecan-1 expression by stromal fibroblasts promotes breast carcinoma growth in vivo and stimulates tumor angiogenesis. Oncogene. 2006;25:1408-12 pubmed
    The induction of the cell surface heparan sulfate proteoglycan syndecan-1 (Sdc1) in stromal fibroblasts is observed in more than 70% of human breast carcinomas...
  11. McQuade K, Rapraeger A. Syndecan-1 transmembrane and extracellular domains have unique and distinct roles in cell spreading. J Biol Chem. 2003;278:46607-15 pubmed
    Raji cells expressing syndecan-1 (Raji-S1) adhere and spread when plated on heparan sulfate-binding extracellular matrix ligands or monoclonal antibody 281.2, an antibody directed against the syndecan-1 extracellular domain...
  12. Ibrahim S, Yip G, Stock C, Pan J, Neubauer C, Poeter M, et al. Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism. Int J Cancer. 2012;131:E884-96 pubmed publisher
    ..In breast cancer, overexpression of the transmembrane heparan sulfate proteoglycan syndecan-1, a predicted target of the oncomiR miR-10b, correlates with poor clinical outcome...
  13. Langford J, Stanley M, Cao D, Sanderson R. Multiple heparan sulfate chains are required for optimal syndecan-1 function. J Biol Chem. 1998;273:29965-71 pubmed
    ..Previously, we demonstrated that expression of wild-type syndecan-1 on these myeloma cells mediates cell-matrix and cell-cell adhesion and inhibits cell invasion into collagen ..
  14. Kokenyesi R, Bernfield M. Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1. J Biol Chem. 1994;269:12304-9 pubmed
    ..that determine whether and where chondroitin sulfate or heparan sulfate will be linked, we have studied mouse syndecan-1, a transmembrane proteoglycan that is invariably glycanated and can contain both chondroitin sulfate and ..
  15. Sanderson R, Lalor P, Bernfield M. B lymphocytes express and lose syndecan at specific stages of differentiation. Cell Regul. 1989;1:27-35 pubmed
    ..Syndecan on B cell precursors is more heterogeneous and slightly larger than on plasma cells. Syndecan 1) is lost immediately before maturation and release of B lymphocytes into the circulation, 2) is absent on ..
  16. Kusumoto T, Kodama J, Seki N, Nakamura K, Hongo A, Hiramatsu Y. Clinical significance of syndecan-1 and versican expression in human epithelial ovarian cancer. Oncol Rep. 2010;23:917-25 pubmed
    ..The aim of this study was to evaluate the expression of syndecan-1 and versican in epithelial ovarian cancer...
  17. Watanabe A, Mabuchi T, Satoh E, Furuya K, Zhang L, Maeda S, et al. Expression of syndecans, a heparan sulfate proteoglycan, in malignant gliomas: participation of nuclear factor-kappaB in upregulation of syndecan-1 expression. J Neurooncol. 2006;77:25-32 pubmed
    ..To clarify the invasion mechanism of tumor cells, expression of the syndecans (syndecan-1, -2, -3, and -4), a major cell surface heparan sulfate proteoglycan family, was analyzed in malignant gliomas...
  18. Martinez A, Spencer M, Brethauer U, Grez P, Marchesani F, Rojas I. Reduction of syndecan-1 expression during lip carcinogenesis. J Oral Pathol Med. 2009;38:580-3 pubmed publisher
    ..b>Syndecan-1, a transmembrane heparan sulfate proteoglycan, modulates cell-proliferation, adhesion, migration and ..
  19. Khotskaya Y, Dai Y, Ritchie J, Macleod V, Yang Y, Zinn K, et al. Syndecan-1 is required for robust growth, vascularization, and metastasis of myeloma tumors in vivo. J Biol Chem. 2009;284:26085-95 pubmed publisher
    Myeloma tumors are characterized by high expression of syndecan-1 (CD138), a heparan sulfate proteoglycan present on the myeloma cell surface and shed into the tumor microenvironment...
  20. Péterfia B, Fule T, Baghy K, Szabadkai K, Fullár A, Dobos K, et al. Syndecan-1 enhances proliferation, migration and metastasis of HT-1080 cells in cooperation with syndecan-2. PLoS ONE. 2012;7:e39474 pubmed publisher
    ..According to earlier studies, both syndecan-1 and syndecan-2 promote malignancy of HT-1080 human fibrosarcoma cells, by increasing the proliferation rate and ..
  21. Pruessmeyer J, Martin C, Hess F, Schwarz N, Schmidt S, Kogel T, et al. A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells. J Biol Chem. 2010;285:555-64 pubmed publisher
    ..Within the lung, syndecan-1 and -4 are expressed as transmembrane proteins on epithelial cells and released in the bronchoalveolar fluid ..
  22. Baba F, Swartz K, van Buren R, Eickhoff J, Zhang Y, Wolberg W, et al. Syndecan-1 and syndecan-4 are overexpressed in an estrogen receptor-negative, highly proliferative breast carcinoma subtype. Breast Cancer Res Treat. 2006;98:91-8 pubmed
    Members of the syndecan and glypican families of cell surface heparan sulfate proteoglycans (HSPGs) are modulators of growth factor signaling and cell adhesion...
  23. Juuti A, Nordling S, Lundin J, Louhimo J, Haglund C. Syndecan-1 expression--a novel prognostic marker in pancreatic cancer. Oncology. 2005;68:97-106 pubmed
    b>Syndecan-1 is a transmembrane receptor that participates in cell-cell and cell-matrix interactions, cell proliferation and cell migration...
  24. Lories V, Cassiman J, Van den Berghe H, David G. Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts. J Biol Chem. 1992;267:1116-22 pubmed
    ..reacted with proteoglycan from mouse mammary epithelial cells, tentatively identified the hybrid proteoglycans as syndecan. The expression of syndecan in lung fibroblasts was confirmed by amplifying syndecan cDNA sequences from ..
  25. Yang Y, Yaccoby S, Liu W, Langford J, Pumphrey C, Theus A, et al. Soluble syndecan-1 promotes growth of myeloma tumors in vivo. Blood. 2002;100:610-7 pubmed
    b>Syndecan-1 (CD138) is a transmembrane heparan sulfate-bearing proteoglycan expressed by most myeloma plasma cells that regulates adhesion, migration, and growth factor activity...
  26. Reiland J, Sanderson R, Waguespack M, Barker S, Long R, Carson D, et al. Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion. J Biol Chem. 2004;279:8047-55 pubmed
    ..b>Syndecan-1, an HSPG, is ubiquitously expressed at the cell surface, and its role in cancer progression may depend upon its ..
  27. Fuhler G, Baanstra M, Chesik D, Somasundaram R, Seckinger A, Hose D, et al. Bone marrow stromal cell interaction reduces syndecan-1 expression and induces kinomic changes in myeloma cells. Exp Cell Res. 2010;316:1816-28 pubmed publisher
    CD138 (Syndecan 1) is a heparan sulfate proteoglycan that concentrates heparan sulfate-binding growth factors on the surface of normal and malignant plasma cells (multiple myeloma, MMC)...
  28. Mali M, Jaakkola P, Arvilommi A, Jalkanen M. Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans. J Biol Chem. 1990;265:6884-9 pubmed
    The structure of human syndecan, an integral membrane proteoglycan, has been determined by cloning its full-length cDNA, which codes for the entire 310-amino acid-long core protein, including the NH2-terminal signal peptide...
  29. Purushothaman A, Uyama T, Kobayashi F, Yamada S, Sugahara K, Rapraeger A, et al. Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. Blood. 2010;115:2449-57 pubmed publisher
    Heparanase enhances shedding of syndecan-1 (CD138), and high levels of heparanase and shed syndecan-1 in the tumor microenvironment are associated with elevated angiogenesis and poor prognosis in myeloma and other cancers...
  30. Nguyen T, Grizzle W, Zhang K, Hameed O, Siegal G, Wei S. Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer. Am J Clin Pathol. 2013;140:468-74 pubmed publisher
    b>Syndecan-1 expression is decreased in diverse tumor types but remains controversial in breast carcinomas. The goal of the study was to examine syndecan-1 expression in breast carcinoma and its prognostic significance...
  31. Beauvais D, Burbach B, Rapraeger A. The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells. J Cell Biol. 2004;167:171-81 pubmed
    ..This paper demonstrates that the alpha(v)beta(3) integrin and syndecan-1 (S1) are functionally coupled...
  32. Marzioni D, Lorenzi T, Mazzucchelli R, Capparuccia L, Morroni M, Fiorini R, et al. Expression of basic fibroblast growth factor, its receptors and syndecans in bladder cancer. Int J Immunopathol Pharmacol. 2009;22:627-38 pubmed
    ..bFGF, its receptors and syndecan immunostaining were mainly present in the urothelium both in normal-looking tissues and urothelial neoplastic ..
  33. Lendorf M, Manon Jensen T, Kronqvist P, Multhaupt H, Couchman J. Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma. J Histochem Cytochem. 2011;59:615-29 pubmed publisher
    b>Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation...
  34. Shafti Keramat S, Handisurya A, Kriehuber E, Meneguzzi G, Slupetzky K, Kirnbauer R. Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses. J Virol. 2003;77:13125-35 pubmed
    ..Of the HSPGs, syndecan-1 is the major epithelial form and is strongly upregulated in wound edge keratinocytes...
  35. Barbareschi M, Maisonneuve P, Aldovini D, Cangi M, Pecciarini L, Angelo Mauri F, et al. High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype and to poorer prognosis. Cancer. 2003;98:474-83 pubmed
    b>Syndecan-1 is a transmembrane heparan sulphate proteoglycan that is involved in cell-cell adhesion, organization of cell-matrix adhesion, and regulation of growth factor signaling...
  36. Hayashida K, Stahl P, Park P. Syndecan-1 ectodomain shedding is regulated by the small GTPase Rab5. J Biol Chem. 2008;283:35435-44 pubmed publisher
    The ectodomain shedding of syndecan-1, a major cell surface heparan sulfate proteoglycan, modulates molecular and cellular processes central to the pathogenesis of inflammatory diseases...
  37. Nikolova V, Koo C, Ibrahim S, Wang Z, Spillmann D, Dreier R, et al. Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression. Carcinogenesis. 2009;30:397-407 pubmed publisher
    The heparan sulfate proteoglycan syndecan-1 (Sdc1) modulates cell proliferation, adhesion, migration and angiogenesis...
  38. Davies E, Blackhall F, Shanks J, David G, McGown A, Swindell R, et al. Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer. Clin Cancer Res. 2004;10:5178-86 pubmed
    ..The expression of syndecan-1, -2, -3, and -4, glypican-1, and perlecan was assessed by immunohistochemistry in 147 biopsies that included ..
  39. Bacsa S, Karasneh G, Dosa S, Liu J, Valyi Nagy T, Shukla D. Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection. J Gen Virol. 2011;92:733-43 pubmed publisher
    ..The objective of this study was to assess the roles of syndecan-1 and syndecan-2 core proteins in HSV-1 infection, both of which are expressed by many HSV-1 target cell types...
  40. Gingis Velitski S, Zetser A, Kaplan V, Ben Zaken O, Cohen E, Levy Adam F, et al. Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. J Biol Chem. 2004;279:44084-92 pubmed
    ..Co-localization studies and cell fractionation following heparanase addition have identified syndecan family members as candidate molecules responsible for heparanase uptake, providing an efficient mechanism that ..
  41. Beauvais D, Rapraeger A. Syndecan-1-mediated cell spreading requires signaling by alphavbeta3 integrins in human breast carcinoma cells. Exp Cell Res. 2003;286:219-32 pubmed
    ..Rev. Biochem. 68 (1999) 729]. While the syndecan heparan sulfate chains are essential for matrix binding, less is known about the signaling role of their core ..
  42. Loussouarn D, Campion L, Sagan C, Frenel J, Dravet F, Classe J, et al. Prognostic impact of syndecan-1 expression in invasive ductal breast carcinomas. Br J Cancer. 2008;98:1993-8 pubmed publisher
    Carcinoma cells lack syndecan-1 expression when they are transiting from an epithelial to a less-differentiated mesenchymal phenotype (epithelial-mesenchymal transition, EMT)...
  43. Deng Y, Foley E, Gonzales J, Gordts P, Li Y, Esko J. Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance. Hepatology. 2012;55:277-86 pubmed publisher
    We recently showed that the heparan sulfate proteoglycan syndecan-1 mediates hepatic clearance of triglyceride-rich lipoproteins in mice based on systemic deletion of syndecan-1 and hepatocyte-specific inactivation of sulfotransferases ..
  44. Lee S, Choi E, Kim M, Park J, Lee Y, Kim S, et al. Prognostic significance of syndecan-1 expression in squamous cell carcinoma of the tonsil. Int J Clin Oncol. 2014;19:247-53 pubmed publisher
    b>Syndecan-1 (SDC1) is reported to modulate several key processes of tumorigenesis and to show variable expression in many cancers. The cause of these variations in expression is not known to date...
  45. Ramani V, Sanderson R. Chemotherapy stimulates syndecan-1 shedding: a potentially negative effect of treatment that may promote tumor relapse. Matrix Biol. 2014;35:215-22 pubmed publisher
    In patients with multiple myeloma, the heparan sulfate proteoglycan syndecan-1 (CD138) is shed from the surface of tumor cells and accumulates in the serum and within the extracellular matrix of the bone marrow where it promotes tumor ..
  46. Ramani V, Pruett P, Thompson C, Delucas L, Sanderson R. Heparan sulfate chains of syndecan-1 regulate ectodomain shedding. J Biol Chem. 2012;287:9952-61 pubmed publisher
    Matrix metalloproteinases release intact syndecan-1 ectodomains from the cell surface giving rise to a soluble, shed form of the proteoglycan...
  47. Chen L, Sanderson R. Heparanase regulates levels of syndecan-1 in the nucleus. PLoS ONE. 2009;4:e4947 pubmed publisher
    b>Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix...
  48. Bode L, Salvestrini C, Park P, Li J, Esko J, Yamaguchi Y, et al. Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. J Clin Invest. 2008;118:229-38 pubmed
    ..Here we show that heparan sulfate and syndecan-1, the predominant intestinal epithelial heparan sulfate proteoglycan, are essential in maintaining intestinal ..
  49. McQuade K, Beauvais D, Burbach B, Rapraeger A. Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts. J Cell Sci. 2006;119:2445-56 pubmed
    B82L mouse fibroblasts respond to fibronectin or vitronectin via a syndecan-1-mediated activation of the alphavbeta5 integrin. Cells attached to syndecan-1-specific antibody display only filopodial extension...
  50. Contreras H, Ledezma R, Vergara J, Cifuentes F, Barra C, Cabello P, et al. The expression of syndecan-1 and -2 is associated with Gleason score and epithelial-mesenchymal transition markers, E-cadherin and beta-catenin, in prostate cancer. Urol Oncol. 2010;28:534-40 pubmed publisher
    ..The aim of this work was to determine the expression and cellular distribution of syndecan-1 and -2 (migration molecules) and E-cadherin and beta-catenin (adhesion molecules) in different stages of ..
  51. Mahtouk K, Hose D, Raynaud P, Hundemer M, Jourdan M, Jourdan E, et al. Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma. Blood. 2007;109:4914-23 pubmed
    The heparan sulfate (HS) proteoglycan, syndecan-1, plays a major role in multiple myeloma (MM) by concentrating heparin-binding growth factors on the surface of MM cells (MMCs)...
  52. Asundi V, Carey D. Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region. J Biol Chem. 1995;270:26404-10 pubmed
    We expressed domains of the core protein of the transmembrane heparan sulfate proteoglycan N-syndecan (syndecan-3) either individually or as maltose-binding protein fusion proteins...
  53. Endo K, Takino T, Miyamori H, Kinsen H, Yoshizaki T, Furukawa M, et al. Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration. J Biol Chem. 2003;278:40764-70 pubmed
    The transmembrane heparan sulfate proteoglycan syndecan-1 was identified from a human placenta cDNA library by the expression cloning method as a gene product that interacts with membrane type matrix metalloproteinase-1 (MT1-MMP)...
  54. Maeda T, Alexander C, Friedl A. Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells. Cancer Res. 2004;64:612-21 pubmed
    ..The cell surface heparan sulfate proteoglycan, syndecan-1 (Sdc1), is thought to function as a coreceptor for growth factor and extracellular matrix interactions, and ..
  55. Yuan K, Hong T, Chen J, Tsai W, Lin M. Syndecan-1 up-regulated by ephrinB2/EphB4 plays dual roles in inflammatory angiogenesis. Blood. 2004;104:1025-33 pubmed
    ..technique and following reverse transcriptase-polymerase chain reaction (RT-PCR), we found that syntenin and syndecan-1 were up-regulated in EphB4-positive endothelial cells dose dependently and time dependently after stimulation ..
  56. Burbach B, Ji Y, Rapraeger A. Syndecan-1 ectodomain regulates matrix-dependent signaling in human breast carcinoma cells. Exp Cell Res. 2004;300:234-47 pubmed
    b>Syndecan-1 was overexpressed in T47D, MCF-7, or Hs578t human breast carcinoma cell lines, mimicking overexpression observed in carcinomas in vivo...
  57. Su G, Blaine S, Qiao D, Friedl A. Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation. Cancer Res. 2008;68:9558-65 pubmed publisher
    ..of T47D breast carcinoma cells and that this activity requires the shedding of the heparan sulfate proteoglycan syndecan-1 (Sdc1) from the fibroblast surface...
  58. Vuoriluoto K, Högnäs G, Meller P, Lehti K, Ivaska J. Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through ?2?1 integrin and MT1-MMP. Matrix Biol. 2011;30:207-17 pubmed publisher
    Syndecans function as co-receptors for integrins on different matrixes. Recently, syndecan-1 has been shown to be important for ?2?1 integrin-mediated adhesion to collagen in tumor cells by regulating cell adhesion and migration on two-..
  59. Ojeh N, Hiilesvuo K, Warri A, Salmivirta M, Henttinen T, Määttä A. Ectopic expression of syndecan-1 in basal epidermis affects keratinocyte proliferation and wound re-epithelialization. J Invest Dermatol. 2008;128:26-34 pubmed
    ..b>Syndecan-1 is a cell-surface proteoglycan that is expressed in differentiating keratinocytes and transiently upregulated ..
  60. Zong F, Fthenou E, Mundt F, Szatmári T, Kovalszky I, Szilak L, et al. Specific syndecan-1 domains regulate mesenchymal tumor cell adhesion, motility and migration. PLoS ONE. 2011;6:e14816 pubmed publisher
    ..Syndecans are involved in many important cellular processes. Our recent publications have demonstrated that syndecan-1 translocates into the nucleus and hampers tumor cell proliferation...
  61. Beauvais D, Ell B, McWhorter A, Rapraeger A. Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med. 2009;206:691-705 pubmed publisher
    b>Syndecan-1 (Sdc1) is a matrix receptor shown to associate via its extracellular domain with the alpha(v)beta(3) and alpha(v)beta(5) integrins, potentially regulating cell adhesion, spreading, and invasion of cells expressing these ..
  62. Li Q, Park P, Wilson C, Parks W. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell. 2002;111:635-46 pubmed
    ..Impaired transepithelial migration was accompanied by a lack of both shed syndecan-1, a heparan sulfate proteoglycan, and KC, a CXC chemokine, in the alveolar fluid...
  63. Fuki I, Kuhn K, Lomazov I, Rothman V, Tuszynski G, Iozzo R, et al. The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro. J Clin Invest. 1997;100:1611-22 pubmed
    ..Here, we studied the involvement of the syndecan proteoglycan family...
  64. Beauvais D, Rapraeger A. Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation. J Cell Sci. 2010;123:3796-807 pubmed publisher
    b>Syndecan-1 (Sdc1) engages and activates the ?v?3 (and/or ?v?5) integrin when clustered in human carcinoma and endothelial cells. Although the engagement is extracellular, the activation mechanism is cytoplasmic...