synaptophysin

Summary

Gene Symbol: synaptophysin
Description: synaptophysin
Alias: MRXSYP, major synaptic vesicle protein P38
Species: human

Top Publications

  1. doi Cornel iridoid glycoside improves memory ability and promotes neuronal survival in fimbria-fornix transected rats
    Li hong Zhao
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, PR China
    Eur J Pharmacol 647:68-74. 2010
  2. ncbi Chronic exposure to estrogen and tamoxifen regulates synaptophysin and phosphorylated cAMP response element-binding (CREB) protein expression in CA1 of ovariectomized rat hippocampus
    K Sharma
    Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Brain Res 1132:10-9. 2007
  3. ncbi The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine
    Haiyun Xu
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Neurochem 91:1380-8. 2004
  4. doi Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin
    Huai Cai Zeng
    Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Synapse 65:225-33. 2011
  5. doi Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice
    Shaokuan Fang
    Department of Neurology, The First Teaching Hospital of Jilin University, Changchun, People s Republic of China
    Biochem Cell Biol 88:655-63. 2010
  6. ncbi Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis?
    Flavia Valtorta
    Department of Neuroscience, S Raffaele Scientific Institute and Vita Salute University, Milan, Italy
    Bioessays 26:445-53. 2004
  7. doi Epileptiform discharge upregulates p-ERK1/2, growth-associated protein 43 and synaptophysin in cultured rat hippocampal neurons
    Zu Cai Xu
    Department of Neurology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
    Seizure 18:680-5. 2009
  8. pmc Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation
    X J Liu
    Loeb Medical Research Institute, Ottawa Civic Hospital, Ontario, Canada
    Mol Cell Biol 15:3563-70. 1995
  9. ncbi Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats
    R Wang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Neuroscience 149:739-46. 2007
  10. ncbi Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis
    T Tauchi
    First Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan
    Blood 87:4495-501. 1996

Scientific Experts

Detail Information

Publications157 found, 100 shown here

  1. doi Cornel iridoid glycoside improves memory ability and promotes neuronal survival in fimbria-fornix transected rats
    Li hong Zhao
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, PR China
    Eur J Pharmacol 647:68-74. 2010
    ..of nerve growth factor (NGF), tyrosine receptor kinase A (Trk A), brain-derived neurotrophic factor (BDNF), synaptophysin (SYP) and B-cell lymphoma-2 (Bcl-2), but not levels of tyrosine receptor kinase B (Trk B) and growth-..
  2. ncbi Chronic exposure to estrogen and tamoxifen regulates synaptophysin and phosphorylated cAMP response element-binding (CREB) protein expression in CA1 of ovariectomized rat hippocampus
    K Sharma
    Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Brain Res 1132:10-9. 2007
    ..Effects on synaptophysin (SYP), a presynaptic vesicular protein, and phosphorylated cyclic AMP responsive element-binding (p-CREB) ..
  3. ncbi The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine
    Haiyun Xu
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Neurochem 91:1380-8. 2004
    ..of neural plasticity in rat hippocampus, we examined two structural proteins involved in neuronal plasticity, synaptophysin (SYP) and microtubule-associated protein 1 (MAP1) for their response to repeated restraint stress and ..
  4. doi Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin
    Huai Cai Zeng
    Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Synapse 65:225-33. 2011
    ..The mRNA levels of synapsin1 (Syn1), synapsin2 (Syn2), and synaptophysin (Syp) were decreased in treated groups either on PND0 or on PND21...
  5. doi Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice
    Shaokuan Fang
    Department of Neurology, The First Teaching Hospital of Jilin University, Changchun, People s Republic of China
    Biochem Cell Biol 88:655-63. 2010
    ..Our preliminary data found that 5 mg.kg-1.d-1 of venlafaxine treatment prevented decreased synaptophysin (SYP) in the hippocampus, which results from chronic restrained stress in the rat model...
  6. ncbi Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis?
    Flavia Valtorta
    Department of Neuroscience, S Raffaele Scientific Institute and Vita Salute University, Milan, Italy
    Bioessays 26:445-53. 2004
    b>Synaptophysin (Syp) was the first synaptic vesicle (SV) protein to be cloned...
  7. doi Epileptiform discharge upregulates p-ERK1/2, growth-associated protein 43 and synaptophysin in cultured rat hippocampal neurons
    Zu Cai Xu
    Department of Neurology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
    Seizure 18:680-5. 2009
    ..The expressions of p-ERK1/2, C-fos, growth-associated protein 43 (GAP-43) and synaptophysin (SYP), as markers of axon growth and synapse reorganization, were investigated by double-label ..
  8. pmc Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation
    X J Liu
    Loeb Medical Research Institute, Ottawa Civic Hospital, Ontario, Canada
    Mol Cell Biol 15:3563-70. 1995
    ....
  9. ncbi Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats
    R Wang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Neuroscience 149:739-46. 2007
    ..The expression of synaptophysin (SYP) in whole hippocampus was measured by using immunohistochemistry...
  10. ncbi Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis
    T Tauchi
    First Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan
    Blood 87:4495-501. 1996
    ..Moreover, Y425 in the EpoR reduces the Epo requirement for Syp tyrosine phosphorylation and promotes proliferation...
  11. ncbi Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor
    T Kimura
    Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 159:4426-34. 1997
    ..Thus, unlike other immune cells in which inhibitory molecules are recruited by accessory proteins, Fc epsilonRI bind molecules that both activate and inhibit signal transduction...
  12. ncbi Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes
    D K Fuhrer
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 270:24826-30. 1995
    ..These findings may have extensive significance to IL-11 and related cytokine signal transduction, suggesting new pathways and mechanisms...
  13. pmc The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells
    Christopher Merritt
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Center for Cell Dynamics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Development 137:1787-98. 2010
    ..We propose that parallel regulation by FBF ensures that in wild-type gonads, meiotic entry is coordinated with just-in-time synthesis of synaptonemal proteins...
  14. pmc An intricate network of regulators controls biofilm formation and colonization by Vibrio fischeri
    Karen L Visick
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL 60153, USA
    Mol Microbiol 74:782-9. 2009
    ..The wealth of regulators and the correlation between biofilm formation and colonization adds to the already considerable utility of the V. fischeri-E. scolopes model system...
  15. ncbi Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor
    R J Lechleider
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts
    J Biol Chem 268:21478-81. 1993
    ..Our data suggest that binding of SH-PTP2 to the activated receptor in vivo should result in stimulation of SH-PTP2 activity...
  16. pmc A single regulatory gene is sufficient to alter bacterial host range
    Mark J Mandel
    Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, 1550 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 458:215-8. 2009
    ....
  17. ncbi [Studies on polysaccharide of Cynomorium songaricum Rupr]
    S J Zhang
    Institute of Chinese Materia, China Academy of Traditional Chinese Medicine, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 26:409-11. 2001
    ..To study the acidic heteropolysac charides of Cynomorium songaricum...
  18. pmc A single unpaired and transcriptionally silenced X chromosome locally precludes checkpoint signaling in the Caenorhabditis elegans germ line
    Aimee Jaramillo-Lambert
    Department of Molecular and Cellular Biology, Genetics Graduate Group, University of California, Davis, California 95616, USA
    Genetics 184:613-28. 2010
    ....
  19. pmc A yeast two-hybrid screen for SYP-3 interactors identifies SYP-4, a component required for synaptonemal complex assembly and chiasma formation in Caenorhabditis elegans meiosis
    Sarit Smolikov
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000669. 2009
    ..Altogether our findings place SYP-4 as a central player in SC formation and broaden our understanding of the structure of the SC and its assembly...
  20. ncbi The peculiar autoimmunity of primary biliary cirrhosis
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Rev 174:226-37. 2000
    ....
  21. ncbi Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp
    G S Feng
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Oncogene 9:1545-50. 1994
    ..The mouse Syp gene has been mapped to chromosome 5F region by the fluorescence in situ hybridization. These findings suggest specific functions for Syp in signal transduction downstream of receptor tyrosine kinases...
  22. ncbi Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584
    W Vogel
    Department of Molecular Biology, Max Planck Institut für Blochemie, Martinsried, Germany
    Cell Growth Differ 7:1589-97. 1996
    ..Immunoprecipitation of SHP-2 from a panel of mammary carcinoma cell lines copurifies several tyrosine phosphorylated proteins; the most prominent band has an apparent molecular weight of M(r) 115,000...
  23. ncbi [Effect of Panax notoginseng saponins on syp and tau gene expression in brain of senescence accelerated mouse]
    Liang Lv
    Center of Research and Development of New Drugs, Guangxi Chinese Traditional Medical University, Nanning 530001, China
    Zhongguo Zhong Yao Za Zhi 34:1261-3. 2009
    To study the effect of Panax notoginseng saponins (PNS) on (synaptophysin, syp) and tau gene expression in the brain tissue in senescence accelerated mouse prone 8 (SAMP 8).
  24. ncbi The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression
    A Symes
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Biol 7:697-700. 1997
    ..These data suggest that SHP-2 has a negative role in gp130 signaling by modulating STAT-mediated transcriptional activation...
  25. doi Developmental increase of asynchronic glutamate release from hippocampal synapses in mutant taiep rat
    Marco Fuenzalida
    Centro de Neurobiología y Plasticidad del Desarrollo, Departamento de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Chile
    Synapse 63:502-9. 2009
    ..In both control and taiep groups, the synaptophysin immunostaining (SYP-IR) in the stratum radiatum of CA1 region was significantly lower in the juvenile (P30) ..
  26. pmc RscS functions upstream of SypG to control the syp locus and biofilm formation in Vibrio fischeri
    Elizabeth A Hussa
    Department of Microbiology and Immunology, Loyola University Chicago, 2160 S First Ave, Maywood, IL 60153, USA
    J Bacteriol 190:4576-83. 2008
    ..Therefore, this work both contributes to our understanding of regulatory pathways important for symbiotic colonization by V. fischeri and establishes a paradigm for evaluating two-component pathways in the genomics era...
  27. pmc The hybrid sensor kinase RscS integrates positive and negative signals to modulate biofilm formation in Vibrio fischeri
    Kati Geszvain
    Department of Microbiology and Immunology, Loyola University Chicago, 2160 S First Ave, Maywood, IL 60153, USA
    J Bacteriol 190:4437-46. 2008
    ..Thus, RscS integrates both inhibitory and stimulatory signals from the environment to regulate biofilm formation by V. fischeri...
  28. doi Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats
    B Chen
    Luzhou Medical College, Department of Neurobiology, 646000, China
    Brain Res 1284:1-11. 2009
    ..Immunohistochemistry was used to identify implanted cells and observe the expressions of Synaptophysin (Syp) and postsynaptic density-95 (PSD-95) and caspase-3...
  29. ncbi Improving the two-step remediation process for CCA-treated wood: Part II. Evaluating bacterial nutrient sources
    Carol A Clausen
    USDA Forest Service, Forest Products Laboratory, One Gifford Pinchot Drive, Madison, WI 53726 2398, USA
    Waste Manag 24:407-11. 2004
    ..The two-step process (oxalic acid extraction and bacterial culture with nutrient medium) appears to be an effective, yet costly, way to remove metals...
  30. pmc SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans
    Sarit Smolikov
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Genetics 176:2015-25. 2007
    ..Altogether, our studies lead us to propose that SYP-3 regulates synapsis along chromosomes, contributing to meiotic progression in early prophase...
  31. pmc Synapsis-defective mutants reveal a correlation between chromosome conformation and the mode of double-strand break repair during Caenorhabditis elegans meiosis
    Sarit Smolikov
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Genetics 176:2027-33. 2007
    ..Moreover, our studies suggest that the conformation of chromosomes may influence the mode of DSB repair employed during meiosis...
  32. doi Moderate exercise changes synaptic and cytoskeletal proteins in motor regions of the rat brain
    Ana F B Ferreira
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Brain Res 1361:31-42. 2010
    ..the acute effects of a moderate forced exercise protocol on synaptic proteins, namely synapsin I (SYN) and synaptophysin (SYP), and structural proteins (neurofilaments, NFs) in rat brain regions related to motor function and often ..
  33. doi Cynomorium songaricum extracts functionally modulate transporters of gamma-aminobutyric acid and monoamine
    Gang Zhao
    Cell Star Bio Technologies Co, Limited, Shanghai, People s Republic of China
    Neurochem Res 35:666-76. 2010
    ..Thus, SY extracts especially SYc and SYb are novel neurotransmitter-transporter modulators functioning as DAT/NET activators and/or GAT-1/SERT inhibitors...
  34. pmc Roles of the structural symbiosis polysaccharide (syp) genes in host colonization, biofilm formation, and polysaccharide biosynthesis in Vibrio fischeri
    Satoshi Shibata
    Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA
    J Bacteriol 194:6736-47. 2012
    ..fischeri to enhance cell-cell interactions and promote symbiotic colonization...
  35. pmc Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts
    Frédéric Massicotte
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Res Ther 8:R177. 2006
    ..The altered response of OA Obs to IGF-1 may be due to abnormal IGF-1 signaling in these cells. This is mostly linked with abnormal IRS-1/Syp and IRS-1/Grb2 interaction in these cells...
  36. pmc The symbiosis regulator rscS controls the syp gene locus, biofilm formation and symbiotic aggregation by Vibrio fischeri
    Emily S Yip
    Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA
    Mol Microbiol 62:1586-600. 2006
    ....
  37. doi Photodegradation of the isoxazolidine fungicide SYP-Z048 in aqueous solution: kinetics and photoproducts
    Pengfei Liu
    College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, People s Republic of China
    J Agric Food Chem 60:11657-63. 2012
    ....
  38. ncbi Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    J Neuropathol Exp Neurol 65:592-601. 2006
    ..We examined protein levels of synaptophysin (SYP), synaptotagmin (SYT), and drebrin (DRB) in 5 neocortical regions (anterior cingulate, superior frontal, ..
  39. doi Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src
    Cinzia Mallozzi
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
    J Neurochem 111:859-69. 2009
    ..In this study we show that, following peroxynitrite treatment, the synaptic vesicle protein synaptophysin (SYP) can be both phosphorylated and nitrated in a dose-dependent manner...
  40. pmc The syp enhancer sequence plays a key role in transcriptional activation by the σ54-dependent response regulator SypG and in biofilm formation and host colonization by Vibrio fischeri
    Valerie A Ray
    Department of Microbiology and Immunology, Loyola University, Chicago, Illinois, USA
    J Bacteriol 195:5402-12. 2013
    ..It may also provide useful insights into other bacteria, such as Vibrio vulnificus and Vibrio parahaemolyticus, that have syp-like loci and conserved SE sequences. ..
  41. pmc A microfluidic culture platform for CNS axonal injury, regeneration and transport
    Anne M Taylor
    Department of Biomedical Engineering, University of California, Irvine, 204 Rockwell Engineering, Irvine, California 92697, USA
    Nat Methods 2:599-605. 2005
    ..The results presented here demonstrate several experimental paradigms using the microfluidic platform, which can greatly facilitate future studies in axonal biology...
  42. ncbi The C-terminal transmembrane region of synaptobrevin binds synaptophysin from adult synaptic vesicles
    Sowmya V Yelamanchili
    AG Funktionelle Zellbiologie, Centrum für Anatomie, Charité Hochschulmedizin Berlin, Philippstrasse 12, D 10115 Berlin, Germany
    Eur J Cell Biol 84:467-75. 2005
    b>Synaptophysin and synaptobrevin are abundant membrane proteins of neuronal small synaptic vesicles. In mature, differentiated neurons they form the synaptophysin/synaptobrevin (Syp/Syb) complex...
  43. pmc The response regulator SypE controls biofilm formation and colonization through phosphorylation of the syp-encoded regulator SypA in Vibrio fischeri
    Andrew R Morris
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL, USA
    Mol Microbiol 87:509-25. 2013
    ..This study demonstrates that regulation of SypA activity by SypE is a critical mechanism by which V. fischeri controls biofilm development and symbiotic colonization...
  44. pmc Detection and organ-specific ablation of neuroendocrine cells by synaptophysin locus-based BAC cassette in transgenic mice
    Chieh Yang Cheng
    Department of Biomedical Sciences, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 8:e60905. 2013
    ..Here we identify a regulatory region sufficient for accurate in vivo expression of synaptophysin (SYP), a common marker of neuroendocrine differentiation, and report generation of Tg(Syp-EGFP(loxP)-DTA)147(..
  45. ncbi Histomorphometric and immunohistochemical study of the goat abomasum during prenatal development
    A Garcia
    Department of Veterinary Histology, Faculty of Veterinary Medicine, University of Extremadura, Caceres, Spain
    Histol Histopathol 28:1639-49. 2013
    ..Neuroendocrine cells were detected by synaptophysin (SYP) at 64 days (CRL 13...
  46. doi Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats
    Predrag Brkić
    Institute of Medical Physiology Richard Burian, School of Medicine, University of Belgrade, Serbia
    Brain Inj 26:1273-84. 2012
    ..To investigate whether hyperbaric oxygenation (HBO) can improve the recovery of motor functions in rats after suction ablation of the right sensorimotor cortex...
  47. pmc The cyclic-di-GMP phosphodiesterase BinA negatively regulates cellulose-containing biofilms in Vibrio fischeri
    Christine M Bassis
    Department of Microbiology and Immunology, Loyola University Chicago, 2160 S First Ave, Bldg 105, Rm 3860A, Maywood, IL 60153, USA
    J Bacteriol 192:1269-78. 2010
    ..fischeri inhibits cellulose-dependent biofilm formation and suggests that the production of two different polysaccharides may be coordinated through the action of the cellulose inhibitor BinA...
  48. ncbi Immunocytochemical detection of synaptophysin in C57BL/6 mice cochlea during aging process
    Maria Visitación Bartolome
    Department of Ophthalmology and Oto Rhino Laringology, Complutense University of Madrid, Apartado de Correos 60 075, 28080 Madrid, Spain
    Brain Res Rev 60:341-8. 2009
    ..However, little is still known about aging effects on synapses in this receptor. Synaptophysin (Syp) is a 38 kDa Ca2+ binding glycoprotein widely found in presynaptic membrane and vesicles...
  49. doi Environmental fate of SYP-1924 residues in rice field
    Xiaodan Zhu
    Institute of Plant and Environmental Protection, Beijing Academy of Agriculture and Forestry Science, 100097 Beijing, China
    Bull Environ Contam Toxicol 84:775-8. 2010
    ..5 days in soil. The ultimate residues of SYP-1924 in rice were found to be below the limits of the detection at level of recommended and 1.5 times recommended dosage with an interval date of 70 days...
  50. ncbi Noise control for 24-hour rock drilling in urban area
    Wilson Ho
    Wilson Acoustics Limited, Unit 616, Technology Park, 18 On Lai Street, Shatin, Hong Kong, China
    J Acoust Soc Am 131:3527. 2012
    ..Groundborne noise impact from rock drilling was predicted within the statutory criteria and verified on site. Construction noise permit for 24-hour rock drilling by 2-boom jumbo drill was obtained...
  51. doi Abnormal innervation patterns in the anorectum of ETU-induced fetal rats with anorectal malformations
    WeiLin Wang
    Department of Pediatric Surgery, Shengjing Hospital, China Medical University, PR China
    Neurosci Lett 495:88-92. 2011
    ..5), nitric oxide synthases (NOs), neuromuscular junction markers (synaptophysin, SYP), interstitial cells of Cajal (ICC) marker (c-kit) within the terminal rectum were analyzed by ..
  52. pmc Clathrin-dependent and independent endocytic pathways in tobacco protoplasts revealed by labelling with charged nanogold
    Elisabetta Onelli
    Department of Biology, University of Milan, Milan, Italy
    J Exp Bot 59:3051-68. 2008
    ..Further experiments using ikarugamycin (IKA), an inhibitor of clathrin-dependent endocytosis, and negatively charged nanogold confirmed that distinct endocytic pathways coexist in tobacco protoplasts...
  53. doi NRSF silencing induces neuronal differentiation of human mesenchymal stem cells
    Yinxiang Yang
    Stem Cells and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, Beijing, China
    Exp Cell Res 314:2257-65. 2008
    ..genes including brain-derived neurotrophic factor (BDNF), neurogenin 1 (NGN1), neuron-specific enolase (NSE), synaptophysin (SYP), and neuron-specific growth-associated protein (SCG10), as well as expressing mature neuronal marker ..
  54. doi Synthesis and fungicidal activities of novel indene-substituted oxime ether strobilurins
    Song Tu
    Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People s Republic of China
    J Agric Food Chem 56:5247-53. 2008
    ..Especially, the 6-methylindene-substituted compound 6p was identified as the most promising candidate for further study...
  55. pmc Organization of the synaptonemal complex during meiosis in Caenorhabditis elegans
    Kristina Schild-Prufert
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 189:411-21. 2011
    ..elegans...
  56. ncbi [Effect of willed movement therapy on GFAP and SYP expression in rats with cerebral ischemia-reperfusion]
    De Ren Hou
    Department of Neurology, Central South University, Changsha, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1543-6. 2011
    To determine the effect of willed movement on the expression of glial fibrillary acidic protein (GFAP) and synaptophysin (SYP) in adult rats with cerebral ischemia-reperfusion, and explore the mechanism of willed movement in promoting ..
  57. doi Inhibin-α and synaptophysin immunoreactivity in synovial sarcoma with granular cell features
    Nokitaka Setsu
    Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 43:850-7. 2012
    We recognized immunoreactivity for the α subset of inhibin and synaptophysin in synovial sarcomas with granular cell features. Histologic findings of 90 cases of synovial sarcoma were reviewed. Two (2...
  58. doi Effect of ephedrine on neuronal plasticity of hypoxic-ischemic brain damage in neonatal rats
    Nong Xiao
    Department of Neurology, Children s Hospital of Chongqing Medical University, Chongqing 400014, China
    Neurosci Lett 435:99-102. 2008
    ..Study the effect of ephedrine on neural plasticity of hypoxic ischemic brain damaged (HIBD) in neonatal rats, and explore the underlying molecular mechanism...
  59. pmc Hippocampal drebrin loss in mild cognitive impairment
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Ill 60612, USA
    Neurodegener Dis 10:216-9. 2012
    ..We examined protein levels of presynaptic synaptophysin (SYP) and synaptotagmin (SYT), and postsynaptic drebrin (DRB), a marker for dendritic spine plasticity, in the ..
  60. pmc Characterization of the transcriptional activators SalA and SyrF, Which are required for syringomycin and syringopeptin production by Pseudomonas syringae pv. syringae
    Nian Wang
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, Texas 77843, USA
    J Bacteriol 188:3290-8. 2006
    ..Both SalA and SyrF resemble other LuxR family proteins in dimerization and interaction with promoter regions of target genes...
  61. ncbi Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints
    R J Sinke
    Department of Human Genetics, University Hospital, Nijmegen, The Netherlands
    Hum Genet 92:305-8. 1993
    ..In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226...
  62. pmc Characterization of a resistance-nodulation-cell division transporter system associated with the syr-syp genomic island of Pseudomonas syringae pv. syringae
    Hyojeung Kang
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, TX 77843, USA
    Appl Environ Microbiol 71:5056-65. 2005
    ..The PseABC efflux system is the first RND transporter system described for P. syringae, and it has an important role in secretion of syringomycin and syringopeptin...
  63. ncbi Identification of protein-tyrosine phosphatases prevalent in adipocytes by molecular cloning
    W Ding
    Dorrance H Hamilton Research Laboratories, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    Biochem Biophys Res Commun 202:902-7. 1994
    ..These data provide insight into PTPase homologs that may have a physiological role in the regulation of phosphotyrosyl turnover in hormone signalling pathways in adipocytes...
  64. ncbi Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1
    S Vainikka
    Department of Pathology, University of Helsinki, Finland
    J Biol Chem 269:18320-6. 1994
    ..Despite these differences, stimulation of both receptors resulted in increased DNA synthesis...
  65. ncbi Dent's disease, a renal Fanconi syndrome with nephrocalcinosis and kidney stones, is associated with a microdeletion involving DXS255 and maps to Xp11.22
    M A Pook
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, London, UK
    Hum Mol Genet 2:2129-34. 1993
    ..22, and a further characterisation of this gene will help to elucidate the factors controlling proximal renal tubular function and the development of kidney stones...
  66. doi Pathological study of pseudohypertrophy of the inferior olivary nucleus
    Katsuhiko Ogawa
    Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Neuropathology 30:15-23. 2010
    ..We used various antibodies to alphaB-crystallin (alphaBC), synaptophysin (SYP), microtubule-associated protein 2 (MAP2), Lys-Asp-Glu-Leu (KDEL) receptors, heat shock protein (HSP) 27 ..
  67. ncbi High-resolution comparative mapping of the proximal region of the mouse X chromosome
    H J Blair
    Genetics Division, MRC Radiobiology Unit, Chilton, Oxon, United Kingdom
    Genomics 28:305-10. 1995
    The murine homologues of the loci for McLeod syndrome (XK), Dent's disease (CICN5), and synaptophysin (SYP) have been mapped to the proximal region of the mouse X chromosome and positioned with respect to other conserved loci in this ..
  68. ncbi The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp
    M R Kuhne
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    J Biol Chem 268:11479-81. 1993
    ..In combination with other findings these results indicate that IRS1 functions as a docking protein for SH2 domain-containing proteins participating in signaling from the insulin receptor...
  69. ncbi Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells
    S X Mu
    Department of Developmental Biology, Amgen Inc, Thousand Oaks, CA 91320, USA
    Blood 86:4532-43. 1995
    ..These include a number of high-molecular-weight proteins (140 to 200 kD) and one 28-kD protein that becomes tyrosine-phosphorylated only briefly...
  70. ncbi Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase
    T C Yeh
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 271:2921-8. 1996
    ..This sequence was utilized to isolate a cDNA clone that encodes a previously uncharacterized 53-kDa protein which, when expressed in mammalian cells, is tyrosine phosphorylated by the insulin receptor...
  71. ncbi Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route
    R M Barge
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 87:2148-53. 1996
    ....
  72. ncbi Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
    L E Marengere
    Amgen Institute, Toronto, Ontario, Canada
    Science 272:1170-3. 1996
    ..The CTLA-4-associated SYP had phosphatase activity toward the RAS regulator p52SHC. Thus, the RAS pathway and T cell activation through the T cell receptor are regulated by CTLA-4-associated SYP...
  73. doi Protective role of dark soy sauce against acrylamide-induced neurotoxicity in rats by antioxidative activity
    Zhang Xichun
    Bio tech Engineering College, Jimei University, Xiamen, Fujian, PR China
    Toxicol Mech Methods 19:369-74. 2009
    ..And it is worthy to note that DSS treatment at the same time as ACR exposure plays a more effective protective role than before or after ACR exposure...
  74. pmc Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release
    H T McMahon
    Howard Hughes Medical Institute, The University of Texas Southwestern Medical School, Dallas 75235, USA
    Proc Natl Acad Sci U S A 93:4760-4. 1996
    b>Synaptophysin (syp I) is a synaptic vesicle membrane protein that constitutes approximately 7% of the total vesicle protein. Multiple lines of evidence implicate syp I in a number of nerve terminal functions...
  75. ncbi Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2
    L Wong
    Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 271:20981-4. 1996
    ..This is the first demonstration of a growth factor- or cytokine-induced coupling of a protein through an SH3 domain and suggests that GRB2 functions to target PTP1D, in addition to Sos, to the plasma membrane in response to EGF...
  76. pmc The putative hybrid sensor kinase SypF coordinates biofilm formation in Vibrio fischeri by acting upstream of two response regulators, SypG and VpsR
    Cynthia L Darnell
    Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA
    J Bacteriol 190:4941-50. 2008
    ..These data support a model in which a network of regulators and at least two polysaccharide loci contribute to biofilm formation in V. fischeri...
  77. pmc Multiple factors contribute to keeping levels of the symbiosis regulator RscS low
    Kati Geszvain
    Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA
    FEMS Microbiol Lett 285:33-9. 2008
    ..Restriction of RscS levels may be important to prevent spurious signalling by this sensor kinase in the absence of a squid host...
  78. ncbi Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp
    S E Fisher
    Department of Biochemistry, Oxford University, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Genomics 45:340-7. 1997
    ..In constructing YAC contigs spanning Xp11. 23-p11.22, we have previously shown that the region around the synaptophysin (SYP) gene is refractory to cloning in YACs, but highly stable in cosmids...
  79. ncbi Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells
    M Masuda
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    FEBS Lett 408:331-6. 1997
    ..Our results suggest that PECAM-1 is a component of a mechanosensing machinery acting upstream of SH-PTP2...
  80. doi Interaction assays in yeast and cultured cells confirm known and identify novel partners of the synaptic vesicle protein synaptophysin
    M Felkl
    Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Neuroscience 156:344-52. 2008
    b>Synaptophysin (SYP) is a major protein of neurotransmitter-containing vesicles spanning the membrane four times and contributing to various aspects of the synaptic vesicle cycle...
  81. ncbi Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval
    D Schindelhauer
    Abteilung für pädiatrische Genetik, Kinderpoliklinik der Universität München, Germany
    Genome Res 6:1056-69. 1996
    ..In addition, the map provides the base to delineate the corresponding syntenic region in the mouse, where the mutants scurfy and tattered are localized...
  82. pmc A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation
    Patrick S Tarpey
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Nat Genet 41:535-43. 2009
    ..The study has, however, also highlighted issues confronting whole-genome sequencing screens, including the observation that loss of function of 1% or more of X-chromosome genes is compatible with apparently normal existence...
  83. pmc Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways
    S Roche
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 15:4940-8. 1996
    ..From these results we concluded that PDGF generates Ras-dependent and Ras-independent pathways important for DNA synthesis...
  84. ncbi Nerve growth factor signal transduction in mature pig oligodendrocytes
    H H Althaus
    Max Planck Institute for Experimental Medicine, AG Neural Regeneration, Gottingen, Germany
    J Neurosci Res 50:729-42. 1997
    ..An in-gel myelin basic protein kinase assay revealed that NGF activates predominantly Erk1. Finally, it is shown that NGF stimulates expression of c-fos...
  85. pmc Immunohistochemical evidence for synaptic release of glutamate from orexin terminals in the locus coeruleus
    P Henny
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Neuroscience 169:1150-7. 2010
    ..A similar proportion of the large Orx+ varicosities contained synaptophysin (Syp), a presynaptic marker for synaptic vesicles...
  86. ncbi Identification of a putative Syp substrate, the PDGF beta receptor
    R A Klinghoffer
    National Jewish Center for Immunology and Respiratory Medicine, Division of Basic Sciences, Denver, Colorado 80206, USA
    J Biol Chem 270:22208-17. 1995
    ....
  87. pmc Control of biofilm formation and colonization in Vibrio fischeri: a role for partner switching?
    Andrew R Morris
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL, USA
    Environ Microbiol 12:2051-9. 2010
    ..The involvement of putative partner-switching components within V. fischeri suggests that tight regulatory control over biofilm formation may be important for the lifestyle of this organism...
  88. pmc Sensor kinase RscS induces the production of antigenically distinct outer membrane vesicles that depend on the symbiosis polysaccharide locus in Vibrio fischeri
    Satoshi Shibata
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, Illinois, USA
    J Bacteriol 194:185-94. 2012
    ..Finally, our data indicate a correlation between OMV production and biofilm formation by V. fischeri...
  89. ncbi The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
    T Tauchi
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202
    J Biol Chem 269:25206-11. 1994
    ..These results suggest that Syp may be an important signaling component downstream of the c-kit receptor and involved in activation of the Ras signaling pathway in hematopoietic cells...
  90. ncbi Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase
    C H Lee
    Laboratory of Molecular Biophysics, Rockefeller University, New York, NY 10021
    Structure 2:423-38. 1994
    ....
  91. pmc Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
    X J Sun
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215
    Mol Cell Biol 13:7418-28. 1993
    ..These results extend the notion that IRS-1 is a multisite docking protein that engages various downstream regulatory elements during insulin signal transmission...
  92. ncbi Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells
    X Y Wang
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 270:27999-8002. 1995
    ..Taken together, these results suggest that IL-11-induced interactions of JAK2, Fyn, and Grb2 may not only provide a novel mechanism for the activation of the Ras/MAPK system but also indicate cross-talk among diverse signaling pathways...
  93. pmc The cDNA and derived amino acid sequences for rat and human synaptophysin
    T C Sudhof
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Health Science Center, Dallas 75235
    Nucleic Acids Res 15:9607. 1987
  94. doi L-type voltage-dependent calcium channels facilitate acetylation of histone H3 through PKCγ phosphorylation in mice with methamphetamine-induced place preference
    Masahiro Shibasaki
    Department of Pharmacology, Kawa saki Medical School, Matsushima, Kurashiki, Japan
    J Neurochem 118:1056-66. 2011
    ....
  95. pmc The role of particle size of particulate nano-zinc oxide wood preservatives on termite mortality and leach resistance
    Carol A Clausen
    U, S, Forest Service, Forest Products Laboratory, Madison, WI 53726, USA
    Nanoscale Res Lett 6:427. 2011
    ..There were no differences in leaching or termite mortality between the two particle sizes of nano-ZnO...
  96. pmc The synaptonemal complex shapes the crossover landscape through cooperative assembly, crossover promotion and crossover inhibition during Caenorhabditis elegans meiosis
    Michiko Hayashi
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 186:45-58. 2010
    ....
  97. ncbi SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
    G S Feng
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Science 259:1607-11. 1993
    ..The Syp gene is widely expressed throughout embryonic mouse development and in adult tissues. Thus, Syp may function in mammalian embryonic development and as a common target of both receptor and nonreceptor tyrosine kinases...
  98. doi Changed clathrin regulatory proteins in the brains of Alzheimer's disease patients and animal models
    Ying Cao
    Department of Pathology, Guiyang Medical University, Guiyang, China
    J Alzheimers Dis 22:329-42. 2010
    In the study, the expression of clathrin regulatory proteins dynamin I, AP180, and synaptic vesicle protein synaptophysin in multiple brain regions of the patients with Alzheimer's disease (AD), the transgenic mice carrying the Swedish ..
  99. pmc The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp
    A Kazlauskas
    National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Proc Natl Acad Sci U S A 90:6939-43. 1993
    ..These data raise the interesting possibility that protein-tyrosine phosphatases contribute to the intracellular relay of biological signals originating from receptor tyrosine kinases such as the PDGFR...
  100. ncbi Synaptic proteins, neuropathology and cognitive status in the oldest-old
    Elizabeth Head
    Institute of Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurobiol Aging 30:1125-34. 2009
    ..b>Synaptophysin (SYN), postsynaptic density 95 (PSD-95) and growth-associated protein 43 (GAP-43) were studied in the frontal ..
  101. doi Neurotoxic phospholipases directly affect synaptic vesicle function
    Philipp Treppmann
    AG Funktionelle Zellbiologie, Institut für Integrative Neuroanatomie, Charité Centrum 2 für Grundlagenmedizin, Berlin, Germany
    J Neurochem 117:757-64. 2011
    ..Here, we report that the SPANs, taipoxin and paradoxin, in nanomolar concentrations directly dissociate the synaptophysin/synaptobrevin (Syp/Syb) complex on isolated synaptic vesicles in the presence of synaptosomal cytosol...

Research Grants68

  1. Synaptonemal complex assembly and function in meiosis
    MONICA P COLAIACOVO; Fiscal Year: 2010
    ..The proposed research will investigate the molecular mechanisms promoting accurate meiotic chromosome segregation thereby laying the foundation for the development of effective preventive strategies. ..
  2. TYROSINE PHOSPHORYLATION AND MAMMALIAN RETINA
    ABBOUD GHALAYINI; Fiscal Year: 2001
    ....
  3. Reprogramming of X-linked genes by nuclear transfer
    X Tian; Fiscal Year: 2003
    ..abstract_text> ..
  4. BCR KINASE IN PDGF-MED EFFECTS IN VASCULAR SMOOTH MUSCLE
    Jun Ichi Abe; Fiscal Year: 2002
    ..We propose that Bcr is a novel downstream component of PDGF receptor signaling in vascular smooth muscle, and may be a candidate gene responsible for the atherosclerosis and restenosis. ..
  5. ALTERED EGF RECEPTORS IN HUMAN GLIAL TUMORS
    Albert Wong; Fiscal Year: 2001
    ..The structure of alternative transcripts from the Gab1 gene in tumors will be determined and their effects on transformation and signaling will be evaluated. ..
  6. MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORS
    Hal Broxmeyer; Fiscal Year: 1999
    ..4) Evaluate roles for the protein tyrosine phosphatases Syp and PRP-1C in synergistically-induced stimulation of cell proliferation and its suppression by chemokine family members. ..
  7. ALCOHOL EFFECTS ON THE LIVER
    Jack Wands; Fiscal Year: 2002
    ....
  8. Synaptonemal complex assembly and function in meiosis
    MONICA P COLAIACOVO; Fiscal Year: 2010
    ..abstract_text> ..
  9. Coordinated regulation of signaling events for insulin biosynthesis and secretion
    Gen Sheng Feng; Fiscal Year: 2010
    ....
  10. Coordinated regulation of signaling events for insulin biosynthesis and secretion
    Gen Sheng Feng; Fiscal Year: 2011
    ....
  11. Coordinated regulation of signaling events for insulin biosynthesis and secretion
    Gen Sheng Feng; Fiscal Year: 2009
    ....
  12. PRIMARY EPO SIGNALS FOR PROERYTHROID CELL EXPANSION
    Don Wojchowski; Fiscal Year: 2002
    ..Insight into regulation of PCD gained from studies of Epo signaling should extend to related clinically important cytokine systems. ..
  13. INTESTINAL CELL GROWTH CONTROL--ROLE OF TYROSINE KINASE
    CHRISTINE CARTWRIGHT; Fiscal Year: 2000
    ..These studies are likely to yield important information regarding the functional aspects of Src as they relate to human colon cancer. ..
  14. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    Karen L Visick; Fiscal Year: 2010
    ....
  15. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    KAREN VISICK; Fiscal Year: 2007
    ..parahaemolyticus and V. vulnificus. Studying this model may also lead to approaches that prevent, reduce or treat such infections. ..
  16. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    KAREN VISICK; Fiscal Year: 2004
    ..Identification and characterization of the critical colonization genes will lay the foundation for understanding signal exchange between a prokaryote and a eukaryote during the establishment of a long-term association. ..
  17. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    KAREN VISICK; Fiscal Year: 2009
    ..parahaemolyticus and V. vulnificus. Studying this model may also lead to approaches that prevent, reduce or treat such infections. ..
  18. VASCULAR ENDOTHELIAL CELL GROWTH FACTOR IN PATHOLOGY
    David Donner; Fiscal Year: 2001
    ..The role of such phosphatases, two in particular- SYP and LAR, in modulating VEGF signaling and cellular responses to VEGF will be defined. ..