SYMPK

Summary

Gene Symbol: SYMPK
Description: symplekin
Alias: SPK, SYM, symplekin
Species: human
Products:     SYMPK

Top Publications

  1. Takagaki Y, Manley J. Complex protein interactions within the human polyadenylation machinery identify a novel component. Mol Cell Biol. 2000;20:1515-25 pubmed
    ..a small region, highly conserved in metazoa, is responsible for interactions with two proteins, CstF-77 and symplekin, a nuclear protein of previously unknown function...
  2. Alqarni I, Bassiouni Y, Badr A, Ali R. Telmisartan and/or chlorogenic acid attenuates fructose-induced non-alcoholic fatty liver disease in rats: Implications of cross-talk between angiotensin, the sphingosine kinase/sphingoine-1-phosphate pathway, and TLR4 receptors. Biochem Pharmacol. 2019;164:252-262 pubmed publisher
    ..As TLR4 and SPK/S1P signaling pathways play important roles in the progression of liver inflammation, the effect on sphingosine ..
  3. Zhang K, Zhang J, Wang X, Wang L, Pugliese M, Passantino A, et al. Cardioprotection of Sheng Mai Yin a classic formula on adriamycin induced myocardial injury in Wistar rats. Phytomedicine. 2018;38:1-11 pubmed publisher
    ..01) in the four drug-administered groups. Moreover, except in the SYM low dose group, IL-6 levels in the other 3 drug-administered groups were also significantly reduced (p?<?.01)...
  4. Socci C, Orsenigo E, Santagostino I, Caumo A, Caldara R, Parolini D, et al. Pancreata from pediatric donors restore insulin independence in adult insulin-dependent diabetes mellitus recipients. Transplant Proc. 2010;42:2068-70 pubmed publisher
    ..2000 to April 2009 we performed 17 pancreas transplantations from pediatric donors: 9 simultaneous kidney-pancreas (SPK), 6 pancreas transplantation alone (PTA), and 2 pancreas after kidney (PAK)...
  5. Burke G, Vendrame F, Virdi S, Ciancio G, Chen L, Ruiz P, et al. Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity. Curr Diab Rep. 2015;15:121 pubmed publisher
    ..We have been performing simultaneous pancreas-kidney (SPK) transplants for over 25 years and find that 6-8 % of our recipients develop T1DR, with symptoms usually becoming ..
  6. Tew G, Michaels J, Crank H, Middleton G, Gumber A, Klonizakis M. Supervised exercise training as an adjunctive therapy for venous leg ulcers: study protocol for a randomised controlled trial. Trials. 2015;16:443 pubmed publisher
    ..healed, percentage and absolute change in ulcer size, health-related quality of life (EQ-5D-5L and VEINES-QOL/Sym), lower-limb cutaneous microvascular function (laser Doppler flowmetry coupled with iontophoresis) and physical ..
  7. Lee S, Masaoka T, Han H, Matsuzaki J, Hong M, Fukuhara S, et al. A prospective study on symptom generation according to spicy food intake and TRPV1 genotypes in functional dyspepsia patients. Neurogastroenterol Motil. 2016;28:1401-8 pubmed publisher
    ..Questionnaires on spicy food intake, patient assessment of gastrointestinal symptoms (PAGI-SYM), patient assessment of quality of life, and hospital anxiety and depression scale were provided...
  8. Sun X, Bonfante P, Tang M. Effect of volatiles versus exudates released by germinating spores of Gigaspora margarita on lateral root formation. Plant Physiol Biochem. 2015;97:1-10 pubmed publisher
    ..We conclude that volatile organic compounds released by the germinating AM fungal spores may stimulate LRF in a symbiosis signaling pathway (SYM)- and host-independent way, whereas GSEs stimulate LRF in a SYM- and host-dependent way.
  9. Noguchi H, Miyasaka Y, Kaku K, Kurihara K, Nakamura U, Okabe Y, et al. Preoperative Muscle Volume Predicts Graft Survival After Pancreas Transplantation: A Retrospective Observational Cohort Study. Transplant Proc. 2018;50:1482-1488 pubmed publisher
    ..A total of 32 and 11 recipients underwent simultaneous pancreas-kidney transplantation (SPK) and PT alone/pancreas after kidney transplantation, respectively...

More Information

Publications127 found, 100 shown here

  1. Huang L, Pyc M, Alseekh S, McCarty D, De Crecy Lagard V, Gregory J, et al. A plastidial pantoate transporter with a potential role in pantothenate synthesis. Biochem J. 2018;475:813-825 pubmed publisher
    ..Taken together, these data indicate that BASS1 is a physiologically significant plastidial pantoate transporter and that the pantoate reduction step in pantothenate biosynthesis could be at least partly localized in plastids. ..
  2. Nakano T, Mizoue S, Fuse N, Iwase A, Matsumoto S, Yoshikawa K. Fixed Combination of Travoprost and Timolol Maleate Reduces Intraocular Pressure in Japanese Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: A Prospective Multicenter Open-Label Study. Adv Ther. 2015;32:823-37 pubmed publisher
    ..There was no significant worsening from baseline for superficial punctate keratopathy (SPK) or conjunctival hyperemia after switching (SPK score: baseline = 0.58 ± 1.31; 12 weeks = 0.92 ± 1.76, P = 0...
  3. Kämpfer P, Jerzak L, Bochenski M, Kasprzak M, Wilharm G, Golke J, et al. Corynebacterium pelargi sp. nov., isolated from the trachea of white stork nestlings. Int J Syst Evol Microbiol. 2015;65:1415-20 pubmed publisher
    ..Putrescine, 1,3-diaminopropane, cadaverine, sym-homospermidine and tyramine were found in minor or trace amounts...
  4. Wang Y, Wang Z, Amyot L, Tian L, Xu Z, Gruber M, et al. Ectopic expression of miR156 represses nodulation and causes morphological and developmental changes in Lotus japonicus. Mol Genet Genomics. 2015;290:471-84 pubmed publisher
    ..to repression of several nodulation genes during the early stages of root development such as three ENOD genes, SymPK, POLLUX, CYCLOPS, Cerberus, and Nsp1, and the stimulation of NFR1...
  5. Singh P, Kumari R, Nayyar N, Lal R. Pontibacter aurantiacus sp. nov. isolated from hexachlorocyclohexane (HCH) contaminated soil. Int J Syst Evol Microbiol. 2017;67:1400-1407 pubmed publisher
    ..Menaquinone-7 (MK-7) was the predominant respiratory quinone and sym-homospermidine was found to be the predominant polyamine in NP1T. The DNA G+C content of NP1T was 52.1±0.7?mol%...
  6. Murai S, Katagiri Y, Yamashita S. Maturation-associated Dbf4 expression is essential for mouse zygotic DNA replication. Dev Growth Differ. 2014;56:625-39 pubmed publisher
    Cdc7 is an S-phase-promoting kinase (SPK) that is required for the activation of replication initiation complex assembly because it phosphorylates the MCM protein complex serving as the replicative helicase in eukaryotic organisms...
  7. Haber P, Elsayed M, Espinoza D, Lintzeris N, Veillard A, Hallinan R. Constipation and other common symptoms reported by women and men in methadone and buprenorphine maintenance treatment. Drug Alcohol Depend. 2017;181:132-139 pubmed publisher
    ..users (n=105) and opioid users not receiving OST (n=87) completed the Patient Assessment of Constipation (PAC-SYM) and a general symptom checklist...
  8. Mouriño Pérez R, Riquelme M, Callejas Negrete O, Galván Mendoza J. Microtubules and associated molecular motors in Neurospora crassa. Mycologia. 2016;108:515-27 pubmed publisher
    ..dynein and dynactin mutants have a scant and disorganized MT cytoskeleton, an erratic and reduced Spitzenkörper (Spk) and distorted hyphal morphology...
  9. Li J, Huang J, Liao S, Wang G. Pseudaminobacter manganicus sp. nov., isolated from sludge of a manganese mine. Int J Syst Evol Microbiol. 2017;67:1589-1594 pubmed publisher
    ..The genomic DNA G+C content was 61.6?mol%. The polyamines of JH-7T were sym-homospermidine (83?%) and putrescine (17?%), and the respiratory quinone was ubiquinone-10...
  10. Haig Y, Enden T, Grøtta O, Kløw N, Slagsvold C, Ghanima W, et al. Post-thrombotic syndrome after catheter-directed thrombolysis for deep vein thrombosis (CaVenT): 5-year follow-up results of an open-label, randomised controlled trial. Lancet Haematol. 2016;3:e64-71 pubmed publisher
    ..with the Villalta score and scores for quality of life at 5 years with EQ-5D and the disease-specific VEINES-QOL/Sym. Analyses were by intention to treat. The trial is registered with ClinicalTrials.gov, number NCT00251771...
  11. Powell F, Harper S, Callaghan C, Shaw A, Godfrey E, Bradley J, et al. Postoperative CT in pancreas transplantation. Clin Radiol. 2015;70:1220-8 pubmed publisher
    To examine the usage and value of computed tomography (CT) following simultaneous pancreas and kidney (SPK) transplantation...
  12. van Vuuren T, van Laanen J, de Geus M, Nelemans P, de Graaf R, Wittens C. A randomised controlled trial comparing venous stenting with conservative treatment in patients with deep venous obstruction: research protocol. BMJ Open. 2017;7:e017233 pubmed publisher
    ..those patients who are treated with stenting experience a change in short form 36 (SF-36) and the Veines-QoL/Sym questionnaires compared with conventionally treated patients...
  13. Shahbazov R, Azari F, Whan P, Wei L, Agarwal A, Brayman K. The successful salvage of a thrombosed pancreatic graft at the early postoperative period of a simultaneous pancreas and kidney transplantation. Int J Surg Case Rep. 2018;45:116-120 pubmed publisher
    ..Interpreting outcomes from our case and other small studies, it appears that endovascular pharmacomechanical thrombectomy can be a vital tool to salvage graft organs in those receiving SPK.
  14. Gruessner A, Laftavi M, Pankewycz O, Gruessner R. Simultaneous Pancreas and Kidney Transplantation-Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry. Curr Diab Rep. 2017;17:44 pubmed publisher
    ..The focus was on simultaneous pancreas/kidney (SPK) transplants, the most common pancreas transplant category...
  15. Callejas Negrete O, Castro Longoria E. The role of GYP-3 in cellular morphogenesis of Neurospora crassa: Analyzing its relationship with the polarisome. Fungal Genet Biol. 2019;128:49-59 pubmed publisher
    ..not necessary for the normal localization of the F-actin population, however the dynamics of the Spitzenkörper (Spk) and the actin population at the apical region seemed to be destabilized...
  16. Misra A, Ou J, Zhu L, Green M. Global analysis of CPSF2-mediated alternative splicing: Integration of global iCLIP and transcriptome profiling data. Genom Data. 2015;6:217-21 pubmed publisher
    ..RNA interference screening strategy, we identified cleavage and polyadenylation specificity factor (CPSF) and symplekin (SYMPK) as cofactors of the well-known splicing regulator RBFOX2...
  17. Frezal L, Demoinet E, Braendle C, Miska E, Felix M. Natural Genetic Variation in a Multigenerational Phenotype in C. elegans. Curr Biol. 2018;: pubmed publisher
    ..and genome editing, we identified the major causal locus as a polymorphism in the set-24 gene, encoding a SET- and SPK-domain protein. We conclude that C...
  18. Helantera I, Anttila V, Loginov R, Lempinen M. Parainfluenza 3 Infections Early After Kidney or Simultaneous Pancreas-Kidney Transplantation. Am J Transplant. 2017;17:809-812 pubmed publisher
    ..outbreak, 45 patients were treated on the ward for postoperative care after kidney or simultaneous pancreas-kidney (SPK) transplantation...
  19. Kämpfer P, Arun A, Busse H, Zhang Z, Young C, Glaeser S. Chelativorans intermedius sp. nov. and proposal to reclassify Thermovum composti as Chelativorans composti comb. nov. Int J Syst Evol Microbiol. 2015;65:1646-52 pubmed publisher
    ..The major polyamine in both strains was sym-homospermidine. Putrescine, spermidine and, for strain CC-MHSW-5(T), spermine were found in minor concentrations...
  20. Prates K, de Oliveira J, Malta A, Matiusso C, Miranda R, Ribeiro T, et al. Sympathetic innervation is essential for metabolic homeostasis and pancreatic beta cell function in adult rats. Mol Cell Endocrinol. 2018;462:119-126 pubmed publisher
    ..of the sympathetic ends that innervate the pancreas, 60-day-old male Wistar rats were subjected to sympathectomy (SYM) or were sham-operated (SO)...
  21. Feng G, Xiong X, Zhu H, Li H. Sphingomonas difficilis sp. nov., a difficultly cultivable bacterium that grows on solid but not in liquid medium, isolated from an abandoned lead-zinc mine. Int J Syst Evol Microbiol. 2017;: pubmed publisher
    ..C14?:?0 2-OH was present as the major hydroxyl fatty acid. The major polyamine was sym-homospermidine, and ubiquinone 10 (Q-10) was the predominant respiratory quinone...
  22. Nguyen N, Kim Y, Hoang V, Tran B, Pham H, Yang D. Paracoccus panacisoli sp. nov., isolated from a forest soil cultivated with Vietnamese ginseng. Int J Syst Evol Microbiol. 2015;65:1491-7 pubmed publisher
    ..The polyamine pattern comprised the major compounds putrescine and spermidine and minor amounts of sym-homospermidine and spermine. The ubiquinone of the strain was Q-10 and the G+C content of its genomic DNA was 68...
  23. Xing J, Xu H, Wang Y, Tang X, Sheng X, Zhan W. Identification of immunogenic proteins and evaluation of four recombinant proteins as potential vaccine antigens from Vibrio anguillarum in flounder (Paralichthys olivaceus). Vaccine. 2017;35:3196-3203 pubmed publisher
    ..The results showed that five immunogenic proteins, VAA, Groel, OmpU, PteF and SpK, were identified; their recombinant proteins, rOmpU, rGroel, rSpK and rVAA, could induce the proliferation of sIg+ ..
  24. Solem C, Patel H, Mehta S, Mody R, Macahilig C, Gao X. Treatment patterns, symptom reduction, quality of life, and resource use associated with lubiprostone in irritable bowel syndrome constipation subtype. Curr Med Res Opin. 2016;32:899-905 pubmed publisher
    ..Main outcomes measures Instruments included Patient Assessment of Constipation Symptoms (PAC-SYM) and IBS quality of life (IBS-QoL). A single item assessed current treatment satisfaction...
  25. Ghanima W, Wik H, Tavoly M, Enden T, Jelsness Jørgensen L. Late consequences of venous thromboembolism: Measuring quality of life after deep vein thrombosis and pulmonary embolism. Thromb Res. 2018;164:170-176 pubmed publisher
    ..The most widely used of these is the VEINES-QOL/Sym, which was developed for CVD...
  26. Vuong Brender T, Suman S, Labouesse M. The apical ECM preserves embryonic integrity and distributes mechanical stress during morphogenesis. Development. 2017;144:4336-4349 pubmed publisher
    ..act in the same pathway, and in parallel to three other putative sheath proteins, the leucine-rich repeat proteins SYM-1, LET-4 and FBN-1/Fibrillin, to ensure embryonic integrity and promote elongation...
  27. Saito Y, Yokota T, Arai M, Tada Y, Sumitani M. Naldemedine in Japanese patients with opioid-induced constipation and chronic noncancer pain: open-label Phase III studies. J Pain Res. 2019;12:127-138 pubmed publisher
    ..Secondary efficacy end points were evaluated at treatment week 2. Patient Assessment of Constipation Symptoms (PAC-SYM) and Quality of Life (PAC-QOL) scores were evaluated in both 48-week studies...
  28. Wright D, Paty J, Turner Bowker D, Bradbury A. Psychometric Evaluation of a New Patient-Reported Outcome (PRO) Symptom Diary for Varicose Veins: VVSymQ(®) Instrument. Patient. 2016;9:335-48 pubmed publisher
    ..symptom impact (the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms [VEINES-QOL/Sym] instrument and the Chronic Venous Insufficiency Quality-of-Life Questionnaire [CIVIQ-20]) than with PRO scores ..
  29. Scalea J, Sultan S, Lamos E, Bartlett S, Barth R. Improvement in Pancreas Transplant Evaluation and Surgical Volume Using a Multidisciplinary Approach. Am J Transplant. 2017;: pubmed publisher
    ..sup>1-3 Further, receiving a simultaneous pancreas kidney (SPK) transplant improves life expectancy over kidney transplantation alone...
  30. Utne K, Dahm A, Wik H, Jelsness Jørgensen L, Sandset P, Ghanima W. Rivaroxaban versus warfarin for the prevention of post-thrombotic syndrome. Thromb Res. 2018;163:6-11 pubmed publisher
    ..PTS was assessed using the Patient Reported Villalta scale. HRQoL was assessed using the EQ-5D-3L and VEINES-QOL/Sym questionnaires. Total 309 patients were included, 161 (52%) treated with rivaroxaban and 148 (48%) with warfarin...
  31. Akter S, Du J, Won K, Yin C, Kook M, Yi T. Sphingosinicella cucumeris sp. nov., isolated from soil of a cucumber garden. Antonie Van Leeuwenhoek. 2015;108:1181-8 pubmed publisher
    ..8 mol% and the predominant respiratory quinone was identified as ubiquinone-10. The major polyamine was found to be sym-homospermidine...
  32. Osman G, Zhang T, Lou K, Gao Y, Chang W, Lin Q, et al. Pontibacter aydingkolensis sp. nov., isolated from soil of a salt lake. Int J Syst Evol Microbiol. 2016;66:5523-5528 pubmed publisher
    ..The polyamine pattern was found to contain mainly sym-homospermidine...
  33. Alvarez Rivera F, Concheiro A, Alvarez Lorenzo C. Epalrestat-loaded silicone hydrogels as contact lenses to address diabetic-eye complications. Eur J Pharm Biopharm. 2018;122:126-136 pubmed publisher
    ..hydrogels were synthesized varying the contents in 2-hydroxyethyl methacrylate (HEMA), monomethacryloxypropyl-sym-polydimethylsiloxane hydroxypropyl terminated (MCS-MC12), and aminopropyl methacrylamide (APMA)...
  34. Gong Z, Zhang C, Jin R, Zhang Y. Steroidobacter flavus sp. nov., a microcystin-degrading Gammaproteobacterium isolated from soil. Antonie Van Leeuwenhoek. 2016;109:1073-9 pubmed publisher
    ..determined to contain spermidine as the predominant polyamine, moderate amounts of putrescine as well as traces of sym-homospermidine and spermine. The respiratory quinone was identified as ubiquinone-8...
  35. Zhu L, Si M, Li C, Xin K, Chen C, Shi X, et al. Sphingomonas gei sp. nov., isolated from roots of Geum aleppicum. Int J Syst Evol Microbiol. 2015;65:1160-6 pubmed publisher
    ..The major polyamine of strain ZFGT-11(T) was sym-homospermidine...
  36. Bauersachs R, Gerlach H, Heinken A, Hoffmann U, Langer F, Noppeney T, et al. Rationale, design, and methodology of the observational INSIGHTS-SVT study on the current state of care and outcomes of patients with superficial vein thrombosis. J Vasc Surg Venous Lymphat Disord. 2017;5:553-560.e1 pubmed publisher
    ..on pain, Venous Insufficiency Epidemiological and Economic Study on Quality of Life/Symptoms [VEINES-QOL/Sym], EuroQol-5 Dimension 5-Level [EQ-5D-5L]) at baseline and at approximately 3 months...
  37. Ichijima H, Karino S, Sakata H, Cavanagh H. Improvement of Subjective Symptoms and Eye Complications When Changing From 2-Week Frequent Replacement to Daily Disposable Contact Lenses in a Subscriber Membership System. Eye Contact Lens. 2016;42:190-5 pubmed publisher
    ..Among eye complications noted in each group, the occurrence of superficial punctate keratitis (SPK) was significantly decreased in DD wear: 9.6% vs. 26.5% (P=0.008, Fisher exact test)...
  38. Teo S, Newton M, Newton R, Dempsey A, Fairchild T. Comparing the Effectiveness of a Short-Term Vertical Jump vs. Weightlifting Program on Athletic Power Development. J Strength Cond Res. 2016;30:2741-8 pubmed publisher
    Teo, SYM, Newton, MJ, Newton, RU, Dempsey, AR, and Fairchild, TJ. Comparing the effectiveness of a short-term vertical jump vs. weightlifting program on athletic power development...
  39. Trinh H, Yi T. Pedobacter humi sp. nov., isolated from a playground soil. Int J Syst Evol Microbiol. 2016;66:2382-8 pubmed publisher
    ..9 mol%. The major polar lipid was phosphatidylethanolamine. The major component in the polyamine pattern was sym-homospermidine...
  40. Palmer J, Hsiao H, Awad L, Binder Macleod S. Symmetry of corticomotor input to plantarflexors influences the propulsive strategy used to increase walking speed post-stroke. Clin Neurophysiol. 2016;127:1837-44 pubmed publisher
    ..The ratio of the paretic and nonparetic peak ankle plantarflexion moments (PF(sym)) was calculated at each speed. CS(PF) predicted the ΔPF(sym) from self-selected and fastest speeds (R(2)=...
  41. Ridier K, Gillon B, Gukasov A, Chaboussant G, Cousson A, Luneau D, et al. Polarized Neutron Diffraction as a Tool for Mapping Molecular Magnetic Anisotropy: Local Susceptibility Tensors in Co(II) Complexes. Chemistry. 2016;22:724-35 pubmed publisher
    ..anisotropy in two paramagnetic high-spin cobalt(II) complexes, namely [Co(II) (dmf)6 ](BPh4 )2 (1) and [Co(II) 2 (sym-hmp)2 ](BPh4 )2 (2), in which dmf=N,N-dimethylformamide; sym-hmp=2,6-bis[(2-hydroxyethyl)methylaminomethyl]-4-..
  42. Agnihotri A, Barola S, Hill C, Neto M, Campos J, Singh V, et al. An Algorithmic Approach to the Management of Gastric Stenosis Following Laparoscopic Sleeve Gastrectomy. Obes Surg. 2017;27:2628-2636 pubmed publisher
    ..Overall, 15 (88.2%) reported clinical improvement with endoscopic management. PAGI-SYM scores revealed that the strongest response to therapy, based on mean reduction of score ± SD, was in the ..
  43. Bengi G, Yalçın M, Akpınar H, Keskinoğlu P, Ellidokuz H. Validity and reliability of the patient assessment of constipation quality of life questionnaire for the Turkish population. Turk J Gastroenterol. 2015;26:309-14 pubmed publisher
    ..For hypothesis verification of the tool, the correlation coefficient for PAC-QOL and PAC Symptoms (PAC-SYM) was r=0.577 (p<0.001), whereas the correlation coefficient for PAC-QOL and constipation severity score was r=0...
  44. Duarte A, Akaishi P, de Molfetta G, Chodraui Filho S, Cintra M, Toscano A, et al. Lacrimal Gland Involvement in Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome. Ophthalmology. 2017;124:399-406 pubmed publisher
    ..Lacrimal meniscus height, Schirmer test I, presence of superficial punctate keratopathy (SPK), LG volume, and molecular analysis of the FOXL2 gene. Absence of LG was detected bilaterally in 9 patients (42...
  45. Ge X, Ding C, Gong J, Tian H, Wei Y, Chen Q, et al. [Short-term efficacy on fecal microbiota transplantation combined with soluble dietary fiber and probiotics in the treatment of slow transit constipation]. Zhonghua Wei Chang Wai Ke Za Zhi. 2016;19:1355-1359 pubmed
    ..Rates of clinical improvement and remission, adverse events, constipation-related symptoms (PAC-SYM scores), bowel movements per week and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-..
  46. Carneiro E, Parolin A, Wichnieski C, Rosa E, Silva Neto U, Westphalen V, et al. Expression levels of the receptor activator of NF-?B ligand and osteoprotegerin and the number of gram-negative bacteria in symptomatic and asymptomatic periapical lesions. Arch Oral Biol. 2017;73:166-171 pubmed publisher
    ..Twenty patients with periapical lesions were divided into two groups: symptomatic (SYM) n=10 and asymptomatic (ASYM) n=10...
  47. Jeon I, Jeannin O, Clérac R, Rouzières M, Fourmigué M. Spin-state modulation of molecular FeIII complexes via inclusion in halogen-bonded supramolecular networks. Chem Commun (Camb). 2017;53:4989-4992 pubmed publisher
    ..Hqsal = N-(8-quinolyl)salicylaldimine) is encapsulated in anionic halogen-bonded 1D and 2D networks derived from sym-triiodotrifluorobenzene, [(C6F3I3)Cl]- and [(C6F3..
  48. Malik Z, Kataria R, Modayil R, Ehrlich A, Schey R, Parkman H, et al. Gastric Per Oral Endoscopic Myotomy (G-POEM) for the Treatment of Refractory Gastroparesis: Early Experience. Dig Dis Sci. 2018;63:2405-2412 pubmed publisher
    ..Thirteen patients undergoing G-POEM are reported. Pre- and post-procedure gastric emptying study (GES) and PAGI-SYM for symptom severity were obtained...
  49. Kong D, Jung S, Jeon H, Kim W, Kim Y, Ha K. A peptide array-based serological protein kinase A activity assay and its application in cancer diagnosis. Analyst. 2015;140:6588-94 pubmed publisher
    ..01 U mL(-1) detection limit. sPKA activity was determined by subtracting nonspecific sPK activity from total sPK activity...
  50. Fernández R, Bavassi L, Campos J, Allegri R, Molina V, Forcato C, et al. Positive modulation of a neutral declarative memory by a threatening social event. Neurobiol Learn Mem. 2015;126:56-66 pubmed publisher
    ..by negative or arousing experiences due to the activation of the stress-responsive sympatho-adrenal-medullary axis (SYM)...
  51. Gao J, Sun P, Mao X, Du Y, Liu B, Sun J. Pedobacter zeae sp. nov., an endophytic bacterium isolated from maize root. Int J Syst Evol Microbiol. 2017;67:231-236 pubmed publisher
    ..5 mol%. The major isoprenoid quinone was menaquinone-7 (MK-7). The major component in the polyamine pattern was sym-homospermidine...
  52. Darter B, Labrecque B, Perera R. Dynamic stability during split-belt walking and the relationship with step length symmetry. Gait Posture. 2018;62:86-91 pubmed publisher
    ..5 m/s: 0.5 m/s). Margins of stability (MoS) and step length symmetry (SYM) were assessed. Stability and symmetry measures each decreased at the onset of the split walking perturbation...
  53. Zhou Y, Xie Z, Zhao J, Du Z, Chen G. Pontibacter locisalis Sy30T sp. nov. isolated from soil collected from an abandoned saltern. Antonie Van Leeuwenhoek. 2016;109:415-20 pubmed publisher
    ..The major menaquinone was MK-7. The major polyamine was sym-homospermidine. The DNA G+C content was 47.7 mol%...
  54. Miyagi S, Fujio A, Tokodai K, Hara Y, Nakanishi C, Goto H, et al. Successful Case of Somatostatin Analog Stopping Gastrointestinal Bleeding, One of the Most Frequent Complications After Simultaneous Pancreas-kidney Transplantation: A Case Report. Transplant Proc. 2016;48:985-7 pubmed publisher
    ..of a patient who experienced massive gastrointestinal bleeding after simultaneous pancreas-kidney transplantation (SPK), which was stopped successfully using somatostatin analog...
  55. Stites E, Wiseman A. Multiorgan transplantation. Transplant Rev (Orlando). 2016;30:253-60 pubmed publisher
    ..These issues persist in the setting of simultaneous pancreas-kidney transplant (SPK), in which utilization for patients with type 1 diabetes has been historically accepted...
  56. Bijkerk R, van der Pol P, Khairoun M, van Gijlswijk Jansen D, Lievers E, de Vries A, et al. Simultaneous pancreas-kidney transplantation in patients with type 1 diabetes reverses elevated MBL levels in association with MBL2 genotype and VEGF expression. Diabetologia. 2016;59:853-8 pubmed publisher
    ..damage, in type 1 diabetes patients with diabetic nephropathy before and after simultaneous pancreas-kidney (SPK) transplantation...
  57. Ito T, Kenmochi T, Ono S, Oshima M, Aida N, Suzuki A, et al. Single institution outcomes in the first 3 years of pancreas transplantation from brain dead donors. J Hepatobiliary Pancreat Sci. 2016;23:270-5 pubmed publisher
    A total of 26 pancreas transplants from brain dead donors, including 21 simultaneous pancreas and kidney (SPK) transplantation procedures, have been performed at Fujita Health University Hospital since the new pancreas transplant program ..
  58. Ge X, Tian H, Ding C, Gu L, Wei Y, Gong J, et al. Fecal Microbiota Transplantation in Combination with Soluble Dietary Fiber for Treatment of Slow Transit Constipation: A Pilot Study. Arch Med Res. 2016;47:236-42 pubmed publisher
    ..Rate of clinical improvement and remission, constipation-related symptoms (PAC-SYM scores), bowel movements per week, colonic transit time (CTT) and gastrointestinal quality-of-life index (GIQLI) ..
  59. den Dekker H, Ros K, de Jongste J, Reiss I, Jaddoe V, Duijts L. Body fat mass distribution and interrupter resistance, fractional exhaled nitric oxide, and asthma at school-age. J Allergy Clin Immunol. 2017;139:810-818.e6 pubmed publisher
    ..40 [0.13-0.68]). A high android/gynoid fat mass ratio was associated with a lower Feno (Sym% [95% CI], -9.8 [-16.3 to -3...
  60. Desseauve D, Legendre M, Dugue Marechaud M, Vequeau Goua V, Pierre F. [Prenatal and clinicopathological study of 6 cases of Pallister-Killian syndrome and review]. Gynecol Obstet Fertil. 2016;44:200-6 pubmed publisher
    ..We found 1 case of left diaphragmatic hernia. Our results are in agreement with the malformation spectrum described in the literature. Some malformation associations could evoke a SPK without classical diaphragmatic hernia.
  61. Bozek Pajak D, Ziaja J, Kowalik A, Farnik M, Kolonko A, Kujawa Szewieczek A, et al. Past Cardiovascular Episodes Deteriorate Quality of Life of Patients With Type 1 Diabetes and End-stage Kidney Disease After Kidney or Simultaneous Pancreas and Kidney Transplantation. Transplant Proc. 2016;48:1667-72 pubmed publisher
    The beneficial influence of kidney (KTx) or simultaneous pancreas and kidney transplantation (SPK) on quality of life (QOL) in patients with end-stage kidney disease caused by type 1 diabetes mellitus was confirmed in many studies...
  62. Gao Y, Wang H, Wu Y. Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report. BMC Ophthalmol. 2018;18:55 pubmed publisher
    Known causes of superficial punctuate keratopathy (SPK) in children include entropion, viral infection, blepharokeratoconjunctivitis (BKC), and toxicity of eye drops...
  63. Schimmer J, Breazzano S. Investor Outlook: Significance of the Positive LCA2 Gene Therapy Phase III Results. Hum Gene Ther Clin Dev. 2015;26:208-10 pubmed publisher
    Spark Therapeutics recently reported positive phase III results for SPK-RPE65 targeting the treatment of visual impairment caused by RPE65 gene mutations (often referred to as Leber congenital amaurosis type 2, or LCA2, but may include ..
  64. Paty J, Elash C, Turner Bowker D. Content Validity for the VVSymQ® Instrument: A New Patient-Reported Outcome Measure for the Assessment of Varicose Veins Symptoms. Patient. 2017;10:51-63 pubmed publisher
    ..instrument began with qualitative interviews with patients based on the symptom domain of the VEINES-QOL/Sym, an existing PRO instrument for chronic venous disorders of the leg...
  65. Tak N, Awasthi E, Bissa G, Meghwal R, James E, Sprent J, et al. Multi locus sequence analysis and symbiotic characterization of novel Ensifer strains nodulating Tephrosia spp. in the Indian Thar Desert. Syst Appl Microbiol. 2016;39:534-545 pubmed publisher
    ..Phylogenetic incongruence between sym and housekeeping genes was observed...
  66. Hjalte F, Ragnarson Tennvall G, Welin K, Westerling D. Treatment of Severe Pain and Opioid-induced Constipation: An Observational Study of Quality of Life, Resource Use, and Costs in Sweden. Pain Ther. 2016;5:227-236 pubmed
    ..instrument, the EuroQol five dimensions questionnaire (EQ-5D), the Patient Assessment of Constipation Symptoms (PAC-SYM) instrument, and the Bowel Function Index (BFI). The analysis included 37 patients...
  67. Park K, Jun H, Kim M, Boo Y, Jung C. Simultaneous pancreas-kidney transplantation from living donor using hand-assisted laparoscopic donor surgery: single-center experience. Transplant Proc. 2015;47:1096-8 pubmed publisher
    Simultaneous pancreas-kidney (SPK) transplantation has been the fundamental treatment and has shown significant results in selected patients diagnosed with type 1 diabetes with renal insufficiency...
  68. Svec P, Kralova S, Busse H, Kleinhagauer T, Kyrova K, Pantucek R, et al. Pedobacter psychrophilus sp. nov., isolated from fragmentary rock. Int J Syst Evol Microbiol. 2017;67:2538-2543 pubmed publisher
    ..Chemotaxonomic analyses of strain P4487AT showed MK-7 as the respiratory menaquinone, sym-homospermidine as the major polyamine, phosphatidylethanolamine and two unidentified lipids as the major polar ..
  69. Lin S, Hameed A, Hsu Y, Liu Y, Hung M, Lai W, et al. Sphingomonas colocasiae sp. nov., isolated from taro (Colocasia esculanta). Int J Syst Evol Microbiol. 2017;: pubmed publisher
    ..5?mol%. The respiratory quinone system and predominant polyamine was ubiquinone 10 (Q-10) and sym-homospermidine, respectively, which is in line with Sphingomonas representatives...
  70. Alwazzan M, Hamshere M, Lennon G, Brook J. Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat. Mamm Genome. 1998;9:485-7 pubmed
  71. Buchert M, Darido C, Lagerqvist E, Sedello A, Cazevieille C, Buchholz F, et al. The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1. Gastroenterology. 2009;137:156-64, 164.e1-3 pubmed publisher
    b>Symplekin is a ubiquitously expressed protein involved in RNA polyadenylation and transcriptional regulation that localizes at tight junctions in epithelial cells...
  72. Qu L, Sun P, Wu Y, Zhang K, Liu Z. Efficient Homodifunctional Bimolecular Ring-Closure Method for Cyclic Polymers by Combining RAFT and Self-Accelerating Click Reaction. Macromol Rapid Commun. 2017;38: pubmed publisher
    ..By virtue of sym-dibenzo-1,5-cyclooctadiene-3,7-diyne (DBA) as small linkers, well-defined cyclic polymers are then prepared using ..
  73. Keon B, Schafer S, Kuhn C, Grund C, Franke W. Symplekin, a novel type of tight junction plaque protein. J Cell Biol. 1996;134:1003-18 pubmed
    ..5 kD, pI 6.25), for which the name "symplekin" (from Greek sigma upsilon mu pi lambda epsilon kappa epsilon iota, nu, to tie together, to weave, to be ..
  74. Fransen K, Visschedijk M, van Sommeren S, Fu J, Franke L, Festen E, et al. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. Hum Mol Genet. 2010;19:3482-8 pubmed publisher
    ..UBE2L3 is also associated with other immune-mediated diseases. These results show that eQTL-based pre-selection for follow-up is a useful approach for identifying risk loci from a moderately sized GWAS. ..
  75. Scheufen T, Krämer W, Iglesias Prieto R, Enríquez S. Seasonal variation modulates coral sensibility to heat-stress and explains annual changes in coral productivity. Sci Rep. 2017;7:4937 pubmed publisher
    ..while Pmax enhancement in the second group was more dependent on Symbiodinium performance (Psym)...
  76. Huang Y, Wei Z, Danzeng W, Kim M, Zhu G, Zhang Y, et al. Sphingomonas antarctica sp. nov., isolated from Antarctic tundra soil. Int J Syst Evol Microbiol. 2017;67:4064-4068 pubmed publisher
    ..Ubiquinone 10 was the predominant respiratory quinone and sym-homospermidine was the polyamine...
  77. Bikbaeva Z, Ivanov D, Novikov A, Ananyev I, Bokach N, Kukushkin V. Electrophilic-Nucleophilic Dualism of Nickel(II) toward Ni···I Noncovalent Interactions: Semicoordination of Iodine Centers via Electron Belt and Halogen Bonding via ?-Hole. Inorg Chem. 2017;56:13562-13578 pubmed publisher
    ..complex [Ni{NH?C(NMe2)NN(O)}2] (1) was cocrystallized with I2 and sym-trifluorotriiodobenzene (FIB) to give associates 1·2I2 and 1·2FIB...
  78. Xing H, Mayhew C, Cullen K, Park Sarge O, Sarge K. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. J Biol Chem. 2004;279:10551-5 pubmed
    ..Here we report an interaction between heat shock factor 1 (HSF1) and symplekin, a protein known to form a complex with the polyadenylation factors CstF and CPSF...
  79. Buchert M, Papin M, Bonnans C, Darido C, Raye W, Garambois V, et al. Symplekin promotes tumorigenicity by up-regulating claudin-2 expression. Proc Natl Acad Sci U S A. 2010;107:2628-33 pubmed publisher
    b>Symplekin is a ubiquitously expressed protein involved in cytoplasmic RNA polyadenylation and transcriptional regulation and is localized at tight junctions (TJs) in epithelial cells...
  80. Xu Q, Sun H, Xiao F, Shi X, Li Y, Wang H, et al. [Roles of SPK in Regulation of Hypoxia Induced Proliferation and Glucose Consume of Leukemia Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:965-969 pubmed publisher
    To clarify the roles of SPK pathway in the regulation of proliferation, survival and glucose consume of human erythroleukemia TF-1 cells...
  81. Nijhoff M, Dubbeld J, van Erkel A, van der Boog P, Rabelink T, Engelse M, et al. Islet allo-autotransplantation: allogeneic pancreas transplantation followed by transplant pancreatectomy and islet transplantation. Am J Transplant. 2017;: pubmed publisher
    Simultaneous pancreas/kidney (SPK) transplantation is an important treatment option for patients with type 1 diabetes (T1D) and end stage renal disease (ESRD)...
  82. Ueki K, Ramaswamy S, Billings S, Mohrenweiser H, Louis D. Chromosomal localization to 19q13.3, partial genomic structure and 5' cDNA sequence of the human symplekin gene. Somat Cell Mol Genet. 1997;23:229-31 pubmed
    Exon trapping from cosmids mapping to chromosome 19q13.3 yielded 6 exonic sequences that matched the human symplekin gene, which encodes a tight junction-related protein. One exonic sequence identified a 4...
  83. Faber P, Barnes G, Srinidhi J, Chen J, Gusella J, MacDonald M. Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet. 1998;7:1463-74 pubmed
    ..The emergence of this class of proteins as huntingtin partners argues that a WW domain-mediated process, such as non-receptor signaling, protein degradation or pre-mRNA splicing, may participate in HD pathogenesis. ..
  84. Kavanagh E, Buchert M, Tsapara A, Choquet A, Balda M, Hollande F, et al. Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin. J Cell Sci. 2006;119:5098-105 pubmed
    ..b>Symplekin, another nuclear protein that can associate with tight junctions, functions in the regulation of polyadenylation ..
  85. Misra A, Ou J, Zhu L, Green M. Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors. Mol Cell. 2015;58:819-31 pubmed publisher
    ..we find that two mRNA 3' end formation factors, cleavage and polyadenylation specificity factor (CPSF) and SYMPK, are RBFOX2 cofactors for both inclusion and exclusion of internal exons...
  86. Kandaswamy R, Stock P, Gustafson S, Skeans M, Curry M, Prentice M, et al. OPTN/SRTR 2015 Annual Data Report: Pancreas. Am J Transplant. 2017;17 Suppl 1:117-173 pubmed publisher
    ..pancreas allocation system revealed no change in the distribution of organs between simultaneous pancreas-kidney (SPK) transplant and pancreas transplant alone. The percentage of kidneys used in SPK transplants was also unchanged...
  87. Kauffmann A, Kennedy S, Zhao J, Turner D. Nuclear Magnetic Resonance Structure of an 8 × 8 Nucleotide RNA Internal Loop Flanked on Each Side by Three Watson-Crick Pairs and Comparison to Three-Dimensional Predictions. Biochemistry. 2017;56:3733-3744 pubmed publisher
    ..Hydrogen bonding patterns between base pairs in the loop, the all-atom root-mean-square deviation for the loop, and the deformation index were used to compare the structure to automated predictions by MC-sym, RNA FARFAR, and RNAComposer.
  88. Brooks J, Liu R, Oliver M, DeLeonibus A, Mei J, White D, et al. Simultaneous Pancreas and Kidney Transplantation is Associated With Inferior Long-Term Outcomes in African Americans. Pancreas. 2017;: pubmed publisher
    Simultaneous pancreas and kidney transplant (SPK) is the most effective treatment for patients with type 1 diabetes mellitus and renal failure. However, the effect of ethnicity on SPK outcomes is not well understood.
  89. Chang H, Zhang C, Cao Y. Expression and distribution of symplekin regulates the assembly and function of the epithelial tight junction. Histochem Cell Biol. 2012;137:319-27 pubmed publisher
    b>Symplekin is multifunctional protein localized to both the tight junction and the nucleus with known roles in mRNA polyadenylation, proliferation, differentiation and tumorigenesis...
  90. Lin S, Hameed A, Liu Y, Hsu Y, Hsieh Y, Lai W, et al. Chryseobacterium endophyticum sp. nov., isolated from a maize leaf. Int J Syst Evol Microbiol. 2017;67:570-575 pubmed publisher
    ..2?mol%. Strain CC-YTH209T contained menaquinone MK-6 as the predominant respiratory quinone and sym-homospermidine as the major polyamine...
  91. Yiannakou Y, Tack J, Piessevaux H, Dubois D, Quigley E, Ke M, et al. The PAC-SYM questionnaire for chronic constipation: defining the minimal important difference. Aliment Pharmacol Ther. 2017;46:1103-1111 pubmed publisher
    The Patient Assessment of Constipation-Symptoms (PAC-SYM) questionnaire is frequently used in clinical trials of constipation...
  92. Sakamoto H, Takeo S, Takashima E, Miura K, Kanoi B, Kaneko T, et al. Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission. Parasitol Int. 2018;67:203-208 pubmed publisher
    ..Malaria asymptomatic volunteers (Asy: n=19) and symptomatic patients (Sym: n=21) were enrolled into the study...