survivin

Summary

Gene Symbol: survivin
Description: baculoviral IAP repeat containing 5
Alias: API4, EPR-1, baculoviral IAP repeat-containing protein 5, apoptosis inhibitor 4, apoptosis inhibitor survivin, survivin variant 3 alpha
Species: human
Products:     survivin

Top Publications

  1. Okamoto K, Okamoto I, Hatashita E, Kuwata K, Yamaguchi H, Kita A, et al. Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin. Mol Cancer Ther. 2012;11:204-13 pubmed publisher
    ..We previously showed that downregulation of the expression of the antiapoptotic protein survivin by EGFR-TKIs contributes to EGFR-TKI-induced apoptosis in EGFR mutation-positive NSCLC cells...
  2. Chu X, Chen L, Wang J, Su Q, Yang J, Lin Y, et al. Overexpression of survivin is correlated with increased invasion and metastasis of colorectal cancer. J Surg Oncol. 2012;105:520-8 pubmed publisher
    The aim of this study was to investigate the association of survivin expression with metastasis of colorectal cancer (CRC)...
  3. Baykara M, Akkus M, Yildiz R, Gonul I, Dursun A, Coskun U, et al. Survivin expression and its potential clinical significance in gastrointestinal stromal sarcoma. Int Immunopharmacol. 2011;11:2227-31 pubmed publisher
    This study was designed to determine the level of survivin expression and its clinical significance as a prognostic factor in gastrointestinal stromal sarcoma (GIST)...
  4. Zahedi P, Aminimoghaddam S, Sayahpour F, Haghpanah V, Amiri P, Fereidoni F, et al. Association of survivin gene polymorphism with endometrial cancer. Int J Gynecol Cancer. 2012;22:35-7 pubmed publisher
    b>Survivin is an inhibitor of apoptosis protein, which is up-regulated in endometrial cancer (EC). A promoter region polymorphism (-31G/C) in the survivin gene has been reported as a modulator of gene expression...
  5. Kim G, Lim S, Kim Y. Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. Mod Pathol. 2011;24:1336-47 pubmed publisher
    ..Intracellular (cytoplasmic and nuclear) localization of survivin has a prognostic significance as an apoptosis inhibitor and a regulator of cell division in tumors...
  6. Rauch A, Hennig D, Schafer C, Wirth M, Marx C, Heinzel T, et al. Survivin and YM155: how faithful is the liaison?. Biochim Biophys Acta. 2014;1845:202-20 pubmed publisher
    b>Survivin belongs to the family of apoptosis inhibitors (IAPs), which antagonizes the induction of cell death...
  7. Güvenç H, Pavlyukov M, Joshi K, Kurt H, Banasavadi Siddegowda Y, Mao P, et al. Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin Cancer Res. 2013;19:631-42 pubmed publisher
    ..The expression of Survivin and Ran was evaluated by immunohistochemistry with GBM tissues, and quantitative reverse transcriptase (qRT)-PCR ..
  8. Rodel F, Sprenger T, Kaina B, Liersch T, Rodel C, Fulda S, et al. Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Curr Med Chem. 2012;19:3679-88 pubmed
    ..Expression of survivin, the smallest and structurally unique member of the inhibitor of apoptosis protein (IAP) family, has been shown ..
  9. Alajez N, Lenarduzzi M, Ito E, Hui A, Shi W, Bruce J, et al. MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res. 2011;71:2381-91 pubmed publisher
    ..Direct interaction between miR-218 and the 3'-untranslated regions (UTR) of mRNAs encoding ROBO1, survivin (BIRC5), and connexin43 (GJA1) was validated in a luciferase-based transcription reporter assay...

More Information

Publications67

  1. Li X, Li S, Yang Z, Cao L, Duan F, Sun X. Polymorphisms of survivin and its protein expression are associated with colorectal cancer susceptibility in Chinese population. DNA Cell Biol. 2013;32:236-42 pubmed publisher
    To investigate the association of survivin -31G/C, -141G/C, and -241T/C polymorphisms with colorectal cancer (CRC) susceptibility and explore the mechanisms of the survivin polymorphism in CRC development...
  2. Wang X, Huang L, Xu Y, Shi Z, Wang Y, Zhang J, et al. Association between survivin -31G > C promoter polymorphism and cancer risk: a meta-analysis. Eur J Hum Genet. 2012;20:790-5 pubmed publisher
    b>Survivin is an inhibitor of apoptosis protein and has a crucial role in the development of cancer. The survivin -31G>C (rs9904341) promoter polymorphism influences survivin expression and has been implicated in cancer risk...
  3. Dong Z, Lu Z, Wang H, Zhang L, Wang Z, Zhang Y, et al. Detection of nuclear matrix protein 22 and survivin baseline level in patients after radical cystectomy. Urol Int. 2011;87:445-9 pubmed publisher
    We investigated the baseline levels of urine nuclear matrix protein 22 (U-NMP22) and survivin in urine after radical cystectomy for primary invasive bladder cancer...
  4. Vegran F, Mary R, Gibeaud A, Mirjolet C, Collin B, Oudot A, et al. Survivin-3B potentiates immune escape in cancer but also inhibits the toxicity of cancer chemotherapy. Cancer Res. 2013;73:5391-401 pubmed publisher
    ..In this study, we investigated the little known alternative splice isoform survivin-3B (S-3B) that is overexpressed in a tumor-specific manner...
  5. Xu P, Xu X, Huang Q, Zhang Z, Zhang Y. CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosis. Med Oncol. 2012;29:1643-7 pubmed publisher
    Cancerous inhibitor of protein phosphatase 2A (CIP2A) and survivin are aberrantly expressed in a wide range of human cancers, including lung tumors...
  6. Antonacopoulou A, Floratou K, Bravou V, Kottorou A, Dimitrakopoulos F, Marousi S, et al. The survivin -31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival. Cell Oncol (Dordr). 2011;34:381-91 pubmed publisher
    b>Survivin is involved in the regulation of cell division and survival, two key processes in cancer...
  7. Dallaglio K, Marconi A, Pincelli C. Survivin: a dual player in healthy and diseased skin. J Invest Dermatol. 2012;132:18-27 pubmed publisher
    b>Survivin belongs to the inhibitor of apoptosis (IAP) protein family, and, in addition to the antiapoptotic functions, it also regulates the cell cycle. The survivin gene generates five major isoforms with diverse and opposite functions...
  8. Gao Q, Yang S, Kang M. Influence of survivin and Bcl-2 expression on the biological behavior of non-small cell lung cancer. Mol Med Rep. 2012;5:1409-14 pubmed publisher
    b>Survivin and Bcl-2 are generally considered to be inhibitors of apoptosis and are frequently overexpressed in several types of human cancers...
  9. Altieri D. Targeting survivin in cancer. Cancer Lett. 2013;332:225-8 pubmed publisher
    With almost 4000 citations in Medline in a little over 10 years, survivin has certainly kept scores of investigators busy worldwide...
  10. Ghadimi M, Young E, Belousov R, Zhang Y, Lopez G, Lusby K, et al. Survivin is a viable target for the treatment of malignant peripheral nerve sheath tumors. Clin Cancer Res. 2012;18:2545-57 pubmed publisher
    To examine the role of survivin as a therapeutic target in preclinical models of human malignant peripheral nerve sheath tumors (MPNST) EXPERIMENTAL DESIGN: Survivin protein expression levels and subcellular localization were examined ..
  11. Ungvári I, Hadadi E, Virag V, Bikov A, Nagy A, Semsei A, et al. Implication of BIRC5 in asthma pathogenesis. Int Immunol. 2012;24:293-301 pubmed publisher
    ..Baculoviral IAP repeat containing 5 (BIRC5) (also known as survivin) is an important anti-apoptotic protein that has been implicated in many cancer types, and recent studies provide ..
  12. Zhu H, Wang Q, Hu C, Zhang W, Quan L, Liu M, et al. High expression of survivin predicts poor prognosis in esophageal squamous cell carcinoma following radiotherapy. Tumour Biol. 2011;32:1147-53 pubmed publisher
    ..Therefore, in this study, we selected patients treated with radiotherapy alone to evaluate survivin as a predictor for radiotherapy...
  13. Hendruschk S, Wiedemuth R, Aigner A, Töpfer K, Cartellieri M, Martin D, et al. RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo. Neuro Oncol. 2011;13:1074-89 pubmed publisher
    ..A likely candidate for an RNAi therapy of gliomas is the inhibitor of apoptosis protein survivin. Survivin is involved in 2 main cellular processes-cell division and inhibition of apoptosis...
  14. Radojevic Skodric S, Basta Jovanovic G, Brasanac D, Nikolic N, Bogdanović L, Milicic B, et al. Survivin gene promoter -31 G/C polymorphism is associated with Wilms tumor susceptibility in Serbian children. J Pediatr Hematol Oncol. 2012;34:e310-4 pubmed publisher
    b>Survivin, an apoptotic inhibitor, is overexpressed in various types of cancer...
  15. Jaiswal P, Goel A, Mandhani A, Mittal R. Functional polymorphisms in promoter survivin gene and its association with susceptibility to bladder cancer in North Indian cohort. Mol Biol Rep. 2012;39:5615-21 pubmed publisher
    b>Survivin is a member of novel inhibitor of apoptosis protein family which expressed in human cancers...
  16. Wen K, Fu Z, Wu X, Feng J, Chen W, Qian J. Oct-4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: effects associated with STAT3/Survivin. Cancer Lett. 2013;333:56-65 pubmed publisher
    ..Knockdown increased apoptosis, decreased CSCs marker expression and weakened tumorigenicity in drug-resistant cell lines. In conclusion, we show that these events can be at least in part attributed to the STAT3/Survivin pathway.
  17. Chen L, Liang L, Yan X, Liu N, Gong L, Pan S, et al. Survivin status affects prognosis and chemosensitivity in epithelial ovarian cancer. Int J Gynecol Cancer. 2013;23:256-63 pubmed publisher
    The objective of this study was to explore the clinical significance of survivin expression in epithelial ovarian cancer (EOC) and the effect of survivin small hairpin RNA (shRNA) on survivin expression, apoptosis, and chemosensitivity in ..
  18. Ge Q, Li Y, Nie Y, Zuo W, DU Y. Expression of survivin and its four splice variants in colorectal cancer and its clinical significances. Med Oncol. 2013;30:535 pubmed publisher
    The aim of this study was to investigate the clinical significances of the mRNA expression of survivin gene and its four splice variants in the pathogenesis of colorectal cancer (CRC)...
  19. Petrarca C, Brunetto A, Duval V, Brondani A, Carvalho G, Garicochea B. Survivin as a predictive biomarker of complete pathologic response to neoadjuvant chemotherapy in patients with stage II and stage III breast cancer. Clin Breast Cancer. 2011;11:129-34 pubmed publisher
    ..The expression levels of survivin, BCL-2, cyclin D1, ETS1, and PDEF in tumor samples obtained in the diagnostic biopsies of patients undergoing ..
  20. Carter B, Qiu Y, Huang X, Diao L, Zhang N, Coombes K, et al. Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML. Blood. 2012;120:173-80 pubmed publisher
    b>Survivin, a member of the inhibitors of apoptosis protein family, plays important roles in cell proliferation and survival and is highly expressed in various malignancies, including leukemias...
  21. Selemetjev S, Dencic T, Marečko I, Jankovic J, Paunovic I, Savin S, et al. Evaluation of survivin expression and its prognostic value in papillary thyroid carcinoma. Pathol Res Pract. 2014;210:30-4 pubmed publisher
    Overexpression of survivin, an inhibitor of apoptosis protein, has been found in a variety of human cancers, and is associated with tumor aggressiveness...
  22. Srivastava K, Srivastava A, Mittal B. Survivin promoter -31G/C (rs9904341) polymorphism and cancer susceptibility: a meta-analysis. Mol Biol Rep. 2012;39:1509-16 pubmed publisher
    This study aimed to perform a meta-analysis to assess the association of survivin -31 G/C promoter polymorphism and cancer risk...
  23. Du J, Kelly A, Funabiki H, Patel D. Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. Structure. 2012;20:185-95 pubmed publisher
    b>Survivin is an inhibitor of apoptosis family protein implicated in apoptosis and mitosis. In apoptosis, it has been shown to recognize the Smac/DIABLO protein...
  24. Lanvin O, Monferran S, Delmas C, Couderc B, Toulas C, Cohen Jonathan Moyal E. Radiation-induced mitotic cell death and glioblastoma radioresistance: a new regulating pathway controlled by integrin-linked kinase, hypoxia-inducible factor 1 alpha and survivin in U87 cells. Eur J Cancer. 2013;49:2884-91 pubmed publisher
    ..Because it is known that HIF-1? controls survivin expression, we then looked at the ILK silencing effect on survivin expression...
  25. Ju J, Yang W, Oh S, Nam K, Lee K, Noh D, et al. HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage. Biochem J. 2013;451:123-34 pubmed publisher
    ..we examined the protein level of Notch target genes in HER2-overexpressing cells, we observed that the level of survivin, downstream of Notch, increased in HER2 cells...
  26. Huang L, Wang D, Chen Y, Zhao C, Gong B, Jiang A, et al. Expression of survivin and patients survival in non-small cell lung cancer: a meta-analysis of the published studies. Mol Biol Rep. 2013;40:917-24 pubmed publisher
    Among new biological markers that could become useful prognostic factors for non-small cell lung cancer (NSCLC). Survivin is one of the most commonly over-expressed oncogenes, however, its role in NSCLC remains controversial...
  27. Jeyaprakash A, Basquin C, Jayachandran U, Conti E. Structural basis for the recognition of phosphorylated histone h3 by the survivin subunit of the chromosomal passenger complex. Structure. 2011;19:1625-34 pubmed publisher
    ..We report the 2.7 Å resolution structure of the CPC subunit Survivin bound to the N-terminal tail of histone H3 carrying the Thr3 phosphorylation mark (Thr3ph)...
  28. Krieg A, Baseras B, Tomczak M, Verde P, Stoecklein N, Knoefel W. Role of survivin as prognostic and clinicopathological marker in gastric cancer: a meta-analysis. Mol Biol Rep. 2013;40:5501-11 pubmed publisher
    b>Survivin has been implicated as a potential prognostic marker in a wide range of malignant tumours. However, the prognostic impact of survivin in gastric cancer remains to be controversial and published data are sometimes heterogeneous...
  29. Li C, Li Z, Zhu M, Zhao T, Chen L, Ji W, et al. Clinicopathological and prognostic significance of survivin over-expression in patients with esophageal squamous cell carcinoma: a meta-analysis. PLoS ONE. 2012;7:e44764 pubmed publisher
    The prognostic significance of survivin for survival of patients with esophageal squamous cell carcinoma (ESCC) remains controversial...
  30. Hmeljak J, Erculj N, Dolzan V, Kern I, Cor A. BIRC5 promoter SNPs do not affect nuclear survivin expression and survival of malignant pleural mesothelioma patients. J Cancer Res Clin Oncol. 2011;137:1641-51 pubmed publisher
    ..Apoptosis deregulation is an important feature of cancer and survivin, a member of the inhibitor-of-apoptosis-protein family encoded by the BIRC5 gene, has been suggested to have a ..
  31. Song J, Su H, Zhou Y, Guo L. Prognostic value of survivin expression in breast cancer patients: a meta-analysis. Tumour Biol. 2013;34:2053-62 pubmed publisher
    The prognostic role of survivin expression in breast cancer patients has been widely reported. However, controversy still remains...
  32. Yamanaka K, Nakahara T, Yamauchi T, Kita A, Takeuchi M, Kiyonaga F, et al. Antitumor activity of YM155, a selective small-molecule survivin suppressant, alone and in combination with docetaxel in human malignant melanoma models. Clin Cancer Res. 2011;17:5423-31 pubmed publisher
    ..Accumulating evidence suggests that survivin is preferentially expressed in cancer cells and plays a crucial role in cell division and apoptosis dysfunction...
  33. Hsieh Y, Tsai C, Yeh C, Yang S, Hsieh Y, Weng C. Survivin T9809C, an SNP located in 3'-UTR, displays a correlation with the risk and clinicopathological development of hepatocellular carcinoma. Ann Surg Oncol. 2012;19 Suppl 3:S625-33 pubmed publisher
    Early detection of hepatocellular carcinoma (HCC) is seldom available because of the lack of reliable markers. Survivin is an anti-apoptotic protein that is implicated in the regulation of apoptosis and cell cycle, and it is undetectable ..
  34. Sun Y, Xuan Q, Shu Q, Wu S, Chen H, Xiao J, et al. Correlation of tumor relapse and elevated expression of survivin and vascular endothelial growth factor in superficial bladder transitional cell carcinoma. Genet Mol Res. 2013;12:1045-53 pubmed publisher
    b>Survivin and vascular endothelial growth factor (VEGF) are newly discovered tumor markers closely correlated with bladder cancer...
  35. Riolo M, Cooper Z, Holloway M, Cheng Y, Bianchi C, Yakirevich E, et al. Histone deacetylase 6 (HDAC6) deacetylates survivin for its nuclear export in breast cancer. J Biol Chem. 2012;287:10885-93 pubmed publisher
    b>Survivin is an oncogenic protein that is highly expressed in breast cancer and has a dual function that is dependent on its subcellular localization...
  36. Krieg A, Werner T, Verde P, Stoecklein N, Knoefel W. Prognostic and clinicopathological significance of survivin in colorectal cancer: a meta-analysis. PLoS ONE. 2013;8:e65338 pubmed publisher
    b>Survivin/BIRC5 is a potentially interesting prognostic marker and therapeutic target in colorectal cancer (CRC). However, the available data on survivin expression in CRC are heterogeneous...
  37. Sun X, Dong X, Lin L, Jiang X, Wei Z, Zhai B, et al. Up-regulation of survivin by AKT and hypoxia-inducible factor 1? contributes to cisplatin resistance in gastric cancer. FEBS J. 2014;281:115-28 pubmed publisher
    This study investigated the contribution of survivin and its upstream regulators, AKT and hypoxia-inducible factor 1? (HIF-1?), to the resistance of gastric cancer cells to cisplatin (CDDP)...
  38. Wang Q, Shu R, He H, Wang L, Ma Y, Zhu H, et al. Co-silencing of Birc5 (survivin) and Hspa5 (Grp78) induces apoptosis in hepatoma cells more efficiently than single gene interference. Int J Oncol. 2012;41:652-60 pubmed publisher
    Birc5 (previously known as survivin) is a cancer-specific protein...
  39. Weng C, Hsieh Y, Chen M, Tsai C, Lin C, Yang S. Survivin SNP-carcinogen interactions in oral cancer. J Dent Res. 2012;91:358-63 pubmed publisher
    In Taiwan, oral cancer is causally associated with environmental carcinogens. Survivin is an anti-apoptotic protein and is generally considered a marker of malignancy...
  40. Reichert S, Rodel C, Mirsch J, Harter P, Tomicic M, Mittelbronn M, et al. Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma. Radiother Oncol. 2011;101:51-8 pubmed publisher
    Gliomas display prime examples of ionizing radiation (IR) resistant tumors. The IAP Survivin is reported to be critically involved in radiation resistance by anti-apoptotic and by caspase-independent mechanisms...
  41. Kelly R, Lopez Chavez A, Citrin D, Janik J, Morris J. Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin. Mol Cancer. 2011;10:35 pubmed publisher
    b>Survivin (BIRC5), a member of the inhibitor of apoptosis protein (IAP) family that inhibits caspases and blocks cell death is highly expressed in cancer and is associated with a poorer clinical outcome...
  42. Jeon C, Kim M, Kwak C, Kim H, Ku J. Prognostic role of survivin in bladder cancer: a systematic review and meta-analysis. PLoS ONE. 2013;8:e76719 pubmed publisher
    ..the present study was to conduct a systematic review and meta-analysis of published literature investigating the survivin expression and its effects on bladder cancer prognosis...
  43. Bury J, Szumiło J, Dabrowski A, Ciechanski A, Sliwinska J, Wallner G. Vascular endothelial growth factor and survivin immunostaining in gastric adenocarcinoma. Pol Przegl Chir. 2012;84:341-7 pubmed publisher
    Two molecules - vascular endothelial growth factor involved in new vessels formation and survivin - antiapoptotic protein, reported to be associated with worse prognosis in various malignancies have been chosen for the study...
  44. Bian K, Fan J, Zhang X, Yang X, Zhu H, Wang L, et al. MicroRNA-203 leads to G1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin. FEBS Lett. 2012;586:804-9 pubmed publisher
    ..Here, we found that miR-203 inhibited the growth of laryngeal cancer cells and survivin was a direct target of miR-203...
  45. Qin C, Cao Q, Li P, Ju X, Wang M, Chen J, et al. Functional promoter -31G>C variant in survivin gene is associated with risk and progression of renal cell cancer in a Chinese population. PLoS ONE. 2012;7:e28829 pubmed publisher
    b>Survivin is an inhibitor of apoptosis protein and is involved in the occurrence and progression of human malignancies...
  46. Moore A, Alonzo T, Gerbing R, Lange B, Heerema N, Franklin J, et al. BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2014;61:647-52 pubmed publisher
    The inhibitor-of-apoptosis protein survivin, encoded by BIRC5, regulates apoptosis, cell division and proliferation...
  47. Isgren A, Forslind K, Erlandsson M, Axelsson C, Andersson S, Lund A, et al. High survivin levels predict poor clinical response to infliximab treatment in patients with rheumatoid arthritis. Semin Arthritis Rheum. 2012;41:652-7 pubmed publisher
    To evaluate if the measurement of survivin in the blood of patients with rheumatoid arthritis (RA) undergoing infliximab treatment has predictive value for treatment response...
  48. Li C, Gou W, Li X, Wang S, Yang T, Chen Q. Reduced expression of survivin, the inhibitor of apoptosis protein correlates with severity of preeclampsia. Placenta. 2012;33:47-51 pubmed publisher
    ..b>Survivin is a member of the inhibitor of apoptosis protein family that uniquely promotes trophoblast proliferation...
  49. Andric M, Nikolic N, Boskovic M, Milicic B, Skodric S, Basta Jovanovic G, et al. Survivin gene promoter polymorphism -31G/C as a risk factor for keratocystic odontogenic tumor development. Eur J Oral Sci. 2012;120:9-13 pubmed publisher
    Several single nucleotide polymorphisms in survivin gene promoters, notably -31G/C, have been shown to modulate the expression and activity of the survivin protein...
  50. Pavlyukov M, Antipova N, Balashova M, Vinogradova T, Kopantzev E, Shakhparonov M. Survivin monomer plays an essential role in apoptosis regulation. J Biol Chem. 2011;286:23296-307 pubmed publisher
    b>Survivin was initially described as an inhibitor of apoptosis and attracted growing attention as one of the most tumor-specific genes in the human genome and a promising target for cancer therapy...
  51. Hernandez J, Farma J, Coppola D, Hakam A, Fulp W, Chen D, et al. Expression of the antiapoptotic protein survivin in colon cancer. Clin Colorectal Cancer. 2011;10:188-93 pubmed publisher
    The antiapoptotic protein survivin has been demonstrated to play an important role in colorectal carcinogenesis...
  52. Liu J, Gao W, Kang Q, Zhang X, Yang S. Prognostic value of survivin in patients with gastric cancer: a systematic review with meta-analysis. PLoS ONE. 2013;8:e71930 pubmed publisher
    The prognostic significance of survivin for the survival of patients with gastric cancer remains controversial...
  53. Li Y, Wang J, Jiang F, Lin W, Meng W. Association of polymorphisms in survivin gene with the risk of hepatocellular carcinoma in Chinese han population: a case control study. BMC Med Genet. 2012;13:1 pubmed publisher
    b>Survivin, one of the strongest apoptosis inhibitors, plays a critical role in the development and progression of hepatocellular carcinoma (HCC)...
  54. Khan S, Jutzy J, Valenzuela M, Turay D, Aspe J, Ashok A, et al. Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer. PLoS ONE. 2012;7:e46737 pubmed publisher
    b>Survivin is expressed in prostate cancer (PCa), and its downregulation sensitizes PCa cells to chemotherapeutic agents in vitro and in vivo...
  55. Yazdani N, Sayahpour F, Haghpanah V, Amiri P, Shahrabi Farahani M, Moradi M, et al. Survivin gene polymorphism association with papillary thyroid carcinoma. Pathol Res Pract. 2012;208:100-3 pubmed publisher
    b>Survivin expression is correlated with suppression of apoptosis in human solid tumors. A polymorphism at position -31 (G/C) (rs 9904341) has been associated with cancer risk in several studies...
  56. Hori M, Miki T, Okamoto M, Yazama F, Konishi H, Kaneko H, et al. The detergent-soluble cytoplasmic pool of survivin suppresses anoikis and its expression is associated with metastatic disease of human colon cancer. PLoS ONE. 2013;8:e55710 pubmed publisher
    b>Survivin is a component of the chromosomal passenger complex (CPC) that is essential for accurate chromosome segregation...
  57. Hingorani P, Dickman P, Garcia Filion P, White Collins A, Kolb E, Azorsa D. BIRC5 expression is a poor prognostic marker in Ewing sarcoma. Pediatr Blood Cancer. 2013;60:35-40 pubmed publisher
    BIRC5 (Survivin), an inhibitor of apoptosis protein (IAP), is over-expressed in several human cancers and increased expression is associated with poor prognosis...
  58. Zu Y, Ban J, Xia Z, Wang J, Cai Y, Ping W, et al. Genetic variation in a miR-335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations. Biochem Biophys Res Commun. 2013;430:529-34 pubmed publisher
    ..Our findings defined a 3' UTR SNP in human BIRC5 oncogene that may increase individual susceptibility to lung cancer probably by attenuating the interaction between miR-335 and BIRC5. ..