Gene Symbol: SUN2
Description: Sad1 and UNC84 domain containing 2
Alias: UNC84B, SUN domain-containing protein 2, Sad1 unc-84 domain protein 2, nuclear envelope protein, protein unc-84 homolog B, rab5-interacting protein, rab5IP, sad1/unc-84 protein-like 2, unc-84 homolog B
Species: human
Products:     SUN2

Top Publications

  1. Haque F, Mazzeo D, Patel J, Smallwood D, Ellis J, Shanahan C, et al. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem. 2010;285:3487-98 pubmed publisher
    ..SUN1 and SUN2 interact with lamin A, but lamin A is only required for NE localization of SUN2, and it remains unclear how SUN1 is ..
  2. Taranum S, Vaylann E, Meinke P, Abraham S, Yang L, Neumann S, et al. LINC complex alterations in DMD and EDMD/CMT fibroblasts. Eur J Cell Biol. 2012;91:614-28 pubmed publisher
    ..that in addition to the disease causing mutations harbour mutations in the Nesprin-1 gene and in the SUN1 and SUN2 gene, respectively...
  3. Hoffenberg S, Liu X, Nikolova L, Hall H, Dai W, Baughn R, et al. A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion. J Biol Chem. 2000;275:24661-9 pubmed
    ..We used a yeast two-hybrid screen to identify a rab5 interacting protein, rab5ip...
  4. Schirmer E, Florens L, Guan T, Yates J, Gerace L. Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science. 2003;301:1380-2 pubmed
    ..Furthermore, 23 of these mapped within chromosome regions linked to a variety of dystrophies. ..
  5. Crisp M, Liu Q, Roux K, Rattner J, Shanahan C, Burke B, et al. Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 2006;172:41-53 pubmed
    ..The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2. Although the outer nuclear membrane (ONM) is continuous with the endoplasmic reticulum, it is nevertheless ..
  6. Liang W, Mitsuhashi H, Keduka E, Nonaka I, Noguchi S, Nishino I, et al. TMEM43 mutations in Emery-Dreifuss muscular dystrophy-related myopathy. Ann Neurol. 2011;69:1005-13 pubmed publisher
    ..Mutations in several nuclear envelope protein genes have been associated with EDMD in less than half of patients, implying the existence of other ..
  7. Randles K, Lam L, Sewry C, Puckelwartz M, Furling D, Wehnert M, et al. Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development. Dev Dyn. 2010;239:998-1009 pubmed publisher
    ..Sun1 and Sun2 proteins remained unchanged during this fibre maturation...
  8. Turgay Y, Ungricht R, Rothballer A, Kiss A, Csucs G, Horvath P, et al. A classical NLS and the SUN domain contribute to the targeting of SUN2 to the inner nuclear membrane. EMBO J. 2010;29:2262-75 pubmed publisher
    ..We have used human SUN2 to delineate features that are required for INM targeting and have identified multiple elements that collectively ..
  9. Sosa B, Rothballer A, Kutay U, Schwartz T. LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins. Cell. 2012;149:1035-47 pubmed publisher
    ..We present crystal structures of the human SUN2-KASH1/2 complex, the core of the LINC complex...

More Information

Publications112 found, 100 shown here

  1. Malone C, Fixsen W, Horvitz H, Han M. UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. Development. 1999;126:3171-81 pubmed
    ..We propose that UNC-84 functions to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage. ..
  2. Gudise S, Figueroa R, Lindberg R, Larsson V, Hallberg E. Samp1 is functionally associated with the LINC complex and A-type lamina networks. J Cell Sci. 2011;124:2077-85 pubmed publisher
    ..subset NE proteins, including emerin, Sun1, endogenous Samp1 and, in some cases, lamin A/C, but not lamin B, Sun2 or nucleoporins...
  3. Sun G, Yuen Chan S, Yuan Y, Wang Chan K, Qiu G, Sun K, et al. Isolation of differentially expressed genes in human heart tissues. Biochim Biophys Acta. 2002;1588:241-6 pubmed
    ..of unknown function in humans: hCALO (human homologue of calossin), NP79 (coding for a nuclear protein of 79KD) and SUN2 (Sad-1 unc-84 domain protein 2)...
  4. Wang Q, Du X, Cai Z, Greene M. Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome. DNA Cell Biol. 2006;25:554-62 pubmed
    ..In the current study we characterized a nuclear envelope protein SUN2 and identified a substructure involved in its localization to the nuclear envelope...
  5. Stewart Hutchinson P, Hale C, Wirtz D, Hodzic D. Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Exp Cell Res. 2008;314:1892-905 pubmed publisher
    ..Here, we show that the KASH domains of Nesprins 1, 2 and 3 interact promiscuously with luminal domains of Sun1 and Sun2. These constructs disrupt endogenous LINC complexes as indicated by the displacement of endogenous Nesprins from ..
  6. Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed publisher
    ..p53 disabled tumor cells could be forced into senescence by expression of a mutant allele of the nuclear envelope protein lamin A...
  7. Chang W, Wang Y, Luxton G, Ostlund C, Worman H, Gundersen G. Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging. Proc Natl Acad Sci U S A. 2019;116:3578-3583 pubmed publisher
    ..The mobilities of three proteins-SUN2, nesprin-2G, and emerin-were reduced in fibroblasts from children with HGPS compared with those in normal ..
  8. Viera A, Alsheimer M, Gómez R, Berenguer I, Ortega S, Symonds C, et al. CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase. J Cell Sci. 2015;128:88-99 pubmed publisher
    ..We propose that during mammalian prophase I the kinase CDK2 is a key factor governing the structure of the nuclear envelope and the telomere-led chromosome movements essential for homolog pairing. ..
  9. Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, et al. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol. 2018;19:189 pubmed publisher
    ..mouse models, we demonstrate that increased Cdc42 activity levels correlate with the repression of the nuclear envelope protein LaminA/C, which controls chromosome 11 distribution, H4K16ac polarity, and nuclear volume and shape in ..
  10. Li P, Noegel A. Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export. Nucleic Acids Res. 2015;43:9874-88 pubmed publisher
    ..Taken together, our results reveal that the inner nuclear envelope protein SUN1 has additional functions aside from being a central component of the LINC complex and that it is an ..
  11. Arai R, En A, Takauji Y, Maki K, Miki K, Fujii M, et al. Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells. Mech Ageing Dev. 2019;178:25-32 pubmed publisher
    ..Here we analysed the role of lamin B receptor (LBR), a nuclear envelope protein that regulates heterochromatin organization, in cellular senescence induced by excess thymidine...
  12. Walters A, COHEN FIX O. Nuclear division: giving daughters their fair share. Curr Biol. 2013;23:R1045-7 pubmed publisher
    ..equally to daughter nuclei during mitosis? In Schizosaccharomyces japonicus, the conserved LEM-domain nuclear envelope protein Man1 ensures the formation of identical daughter nuclei by coupling nuclear pore complexes to the ..
  13. Wang S, Gu Y, Zebell S, Anderson L, Wang W, Mohan R, et al. A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity. Cell Host Microbe. 2014;16:787-94 pubmed publisher
    ..We show that the Arabidopsis nuclear envelope protein, CPR5, negatively regulates ETI and the associated PCD through a physical interaction with cyclin-..
  14. Ungricht R, Klann M, Horvath P, Kutay U. Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane. J Cell Biol. 2015;209:687-703 pubmed publisher
    ..Using human LBR, SUN2, and LAP2β as model substrates, we show that INM targeting is energy-dependent but distinct from import of ..
  15. Zhou X, Groves N, Meier I. SUN anchors pollen WIP-WIT complexes at the vegetative nuclear envelope and is necessary for pollen tube targeting and fertility. J Exp Bot. 2015;66:7299-307 pubmed publisher
    ..To explore this question, a SUN2 lumenal domain that was targeted to the ER specifically in pollen was over-expressed...
  16. Mattioli E, Columbaro M, Jafferali M, Schena E, Hallberg E, Lattanzi G. Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy. Cells. 2018;7: pubmed publisher
    ..mutations do not alter Samp1 localization in myotubes, which suggests that Samp1 lies upstream of SUN1 in nuclear envelope protein complexes...
  17. Zuleger N, Kelly D, Richardson A, Kerr A, Goldberg M, Goryachev A, et al. System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics. J Cell Biol. 2011;193:109-23 pubmed publisher
    ..Modeling of three proteins that were unaffected by either ATP or Ran depletion indicates that the wide range in mobilities could be explained by differences in binding affinities in the inner nuclear membrane. ..
  18. Díaz Hernández J, Sebastián Serrano A, Gomez Villafuertes R, Diaz Hernandez M, Miras Portugal M. Age-related nuclear translocation of P2X6 subunit modifies splicing activity interacting with splicing factor 3A1. PLoS ONE. 2015;10:e0123121 pubmed publisher
    ..the nucleus, where it presents a speckled distribution pattern and is retained by interaction with the nuclear envelope protein spectrin α2...
  19. Imai R, Asai K, Hanai J, Takenaka M. Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation. Aging (Albany NY). 2015;7:486-99 pubmed
    ..The production of an abnormal lamin A, a nuclear envelope protein, plays a causal role in both normal aging and accelerated aging diseases, known as laminopathies...
  20. Matsumoto A, Sakamoto C, Matsumori H, Katahira J, Yasuda Y, Yoshidome K, et al. Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli. Nucleus. 2016;7:68-83 pubmed publisher
    ..We found that a reduction in the levels of SUN1, SUN2, and lamin A/C led to significant changes in morphologies that were computationally classified using wndchrm with ..
  21. Chen C, Chi Y, Mutalif R, Starost M, Myers T, Anderson S, et al. Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell. 2012;149:565-77 pubmed publisher
    ..Collectively, these findings implicate Sun1 protein accumulation as a common pathogenic event in Lmna(-/-), LmnaΔ9, and HGPS disorders. ..
  22. Lautscham L, Kämmerer C, Lange J, Kolb T, Mark C, Schilling A, et al. Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness. Biophys J. 2015;109:900-13 pubmed publisher
    ..with different amounts of adhesion proteins, and we increase cell stiffness by overexpression of the nuclear envelope protein lamin A. Although all cell lines are able to migrate through the smallest 1...
  23. Synofzik M, Smets K, Mallaret M, Di Bella D, Gallenmüller C, Baets J, et al. SYNE1 ataxia is a common recessive ataxia with major non-cerebellar features: a large multi-centre study. Brain. 2016;139:1378-93 pubmed publisher
    Mutations in the synaptic nuclear envelope protein 1 (SYNE1) gene have been reported to cause a relatively pure, slowly progressive cerebellar recessive ataxia mostly identified in Quebec, Canada...
  24. Hennen J, Hur K, Saunders C, Luxton G, MUELLER J. Quantitative Brightness Analysis of Protein Oligomerization in the Nuclear Envelope. Biophys J. 2017;113:138-147 pubmed publisher
    ..these insights to study the oligomerization of the luminal domains of two nuclear membrane proteins, nesprin-2 and SUN2, which interact transluminally to form a nuclear envelope-spanning linker molecular bridge known as the linker of ..
  25. Synofzik M, Nemeth A. Recessive ataxias. Handb Clin Neurol. 2018;155:73-89 pubmed publisher
    ..ataxia, autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and spectrin repeat-containing nuclear envelope protein (SYNE)-related ataxia...
  26. Vander Heyden A, Naismith T, Snapp E, Hodzic D, Hanson P. LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation. Mol Biol Cell. 2009;20:2661-72 pubmed publisher
    ..When concentrated in the NE, TorA displaces the nuclear membrane proteins Sun2, nesprin-2G, and nesprin-3 while leaving nuclear pores and Sun1 unchanged...
  27. Chen X, Li W, Chen Y, Li X, Li H, Huang H, et al. Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis. Cell Death Dis. 2018;9:1021 pubmed publisher
    ..Interestingly, we found SAD1/UNC84 domain protein-2 (SUN2) gene hypermethylation at CpG sites during liver fibrogenesis in mice with CCl4-induced hepatic fibrosis,..
  28. Steiner F, Henikoff S. Cell type-specific affinity purification of nuclei for chromatin profiling in whole animals. Methods Mol Biol. 2015;1228:3-14 pubmed publisher
    ..for Isolation of Nuclei TAgged in specific Cell Types, depends on the expression of an affinity-tagged nuclear envelope protein in the cell type of interest...
  29. Przybycien Szymanska M, Yang Y, Ashley W. Microparticle derived proteins as potential biomarkers for cerebral vasospasm post subarachnoid hemorrhage. A preliminary study. Clin Neurol Neurosurg. 2016;141:48-55 pubmed publisher
    ..ApoE, ApoD, synaptic nuclear envelope protein 1, clusterin, α-1-acid glycoprotein, plasma protease C1 inhibitor, and prostaglandin H2 D isomerase ..
  30. Freeburg S, Engelbrecht E, Powell W. Subfunctionalization of Paralogous Aryl Hydrocarbon Receptors from the Frog Xenopus Laevis: Distinct Target Genes and Differential Responses to Specific Agonists in a Single Cell Type. Toxicol Sci. 2017;155:337-347 pubmed publisher
    ..induced target genes, encoding aryl hydrocarbon receptor repressor (AHRR), spectrin repeat-containing nuclear envelope protein 1 (SYNE-1), and gap junction protein gamma 1 (GJC1), were regulated solely by AHR1?...
  31. Zhang W, Bai T, Zhang S, Xu S, Chen H, Li C. Isoforms of the nuclear envelope protein Nurim are differentially expressed during heart development in mice. Gene. 2017;627:123-128 pubmed publisher
    To date, transcript variants of the nuclear envelope protein Nurim and their expression profiles in mice have never been elucidated...
  32. Hennen J, Saunders C, MUELLER J, Luxton G. Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells. Mol Biol Cell. 2018;: pubmed publisher
    ..Recently, KASH proteins were shown to bind to the domain interfaces of trimeric SUN2 proteins in vitro However neither the existence of SUN2 trimers in living cells nor the extent to which ..
  33. Hennen J, Hur K, Karuka S, Luxton G, MUELLER J. Protein oligomerization and mobility within the nuclear envelope evaluated by the time-shifted mean-segmented Q factor. Methods. 2019;157:28-41 pubmed publisher
    ..The results for the luminal domain of SUN2 obtained through tsMSQ without correction for non-ideal detector effects agree with a recent study that was ..
  34. Korfali N, Srsen V, Waterfall M, Batrakou D, Pekovic V, Hutchison C, et al. A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/Tmem53 as involved in stress-dependent cell cycle withdrawal. PLoS ONE. 2011;6:e18762 pubmed publisher
    Disruption of cell cycle regulation is one mechanism proposed for how nuclear envelope protein mutation can cause disease...
  35. Zhou X, Groves N, Meier I. Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1. Nucleus. 2015;6:144-53 pubmed publisher
    ..Recently, an interaction between Arabidopsis SUN1 and SUN2 proteins and CRWN1, a plant analog of lamins, has been reported...
  36. Jahed Z, Shams H, Mofrad M. A Disulfide Bond Is Required for the Transmission of Forces through SUN-KASH Complexes. Biophys J. 2015;109:501-9 pubmed publisher
    ..Herein, using molecular dynamics, we examine the effect of tension on the human SUN2-KASH2 complex and show that it is remarkably stable under physiologically relevant tensile forces and large strains...
  37. Malu K, Garhwal R, Pelletier M, Gotur D, Halene S, Zwerger M, et al. Cooperative Activity of GABP with PU.1 or C/EBP? Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation. J Immunol. 2016;197:910-22 pubmed publisher
    ..These findings demonstrate that GABP, PU.1, and C/EBP? cooperate to control transcription of the gene encoding LBR, a nuclear envelope protein that is required for the characteristic lobulated morphology of mature neutrophils.
  38. Luo X, Yang W, Gao G. SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A. J Virol. 2018;92: pubmed publisher
    ..The nuclear membrane-imbedded protein SUN2 was recently reported to be involved in the nuclear import of HIV-1...
  39. Majumder S, Willey P, Denies M, Liu A, Luxton G. A synthetic biology platform for the reconstitution and mechanistic dissection of LINC complex assembly. J Cell Sci. 2018;132: pubmed publisher
    ..We demonstrate that SUN1 and SUN2 are oriented in ANMs with solvent-exposed C-terminal KASH-binding SUN domains...
  40. Blau Wasser R, Euteneuer U, Xiong H, Gassen B, Schleicher M, Noegel A. CP250, a novel acidic coiled-coil protein of the Dictyostelium centrosome, affects growth, chemotaxis, and the nuclear envelope. Mol Biol Cell. 2009;20:4348-61 pubmed publisher
    ..Furthermore, loss of CP250 affected the nuclear envelope and led to reduced amounts and altered distribution of Sun-1, a conserved nuclear envelope protein that connects the centrosome to chromatin.
  41. Tapia O, Fong L, Huber M, Young S, Gerace L. Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS ONE. 2015;10:e0116196 pubmed publisher
    ..Since increased MAP kinase and AKT/mTORC signaling is found in other animal models for diseases linked to nuclear lamina proteins, LEMD2 should be considered to be another candidate gene for human disease. ..
  42. Samson C, Herrada I, Celli F, Theillet F, Zinn Justin S. 1H, 13C and 15N backbone resonance assignment of the intrinsically disordered region of the nuclear envelope protein emerin. Biomol NMR Assign. 2016;10:179-82 pubmed publisher
    ..Chemical shift analysis confirms that this fragment is intrinsically disordered in 0 and 8 M urea. ..
  43. Piekarowicz K, Machowska M, Dratkiewicz E, Lorek D, Madej Pilarczyk A, Rzepecki R. The effect of the lamin A and its mutants on nuclear structure, cell proliferation, protein stability, and mobility in embryonic cells. Chromosoma. 2017;126:501-517 pubmed publisher
    ..different cell types and analyzed proteins' impact on proliferation, protein mobility, and endogenous nuclear envelope protein distribution. The mutants give rise to a broad spectrum of nuclear phenotypes and relocate lamin C...
  44. Myers K, Barone G, Ganesh A, Staples C, Howard A, Beveridge R, et al. The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability. Sci Rep. 2016;6:35548 pubmed publisher well as premature centrosome splitting, which we attribute in part, to improper localisation of the nuclear envelope protein TPR...
  45. Le Thanh P, Meinke P, Korfali N, Srsen V, Robson M, Wehnert M, et al. Immunohistochemistry on a panel of Emery-Dreifuss muscular dystrophy samples reveals nuclear envelope proteins as inconsistent markers for pathology. Neuromuscul Disord. 2017;27:338-351 pubmed publisher
    ..The absence of striking uniform defects in nuclear envelope protein distribution indicates that such staining will be unavailing for general diagnostics, though it remains ..
  46. Shimamoto Y, Tamura S, Masumoto H, Maeshima K. Nucleosome-nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity. Mol Biol Cell. 2017;28:1580-1589 pubmed publisher
    ..the levels of key chromatin assembly factors, including cohesin, condensin II, and CTCF, and a major nuclear envelope protein, lamin, are unaffected...
  47. Yang Y, Qu R, Fan T, Zhu X, Feng Y, Yang Y, et al. Cross-talk between microtubules and the linker of nucleoskeleton complex plays a critical role in the adipogenesis of human adipose-derived stem cells. Stem Cell Res Ther. 2018;9:125 pubmed publisher
    ..hASCs were transfected with a SUN2-specific shRNA to knockdown sun2, and a nontargeting shRNA was used as a control...
  48. Cruz Ramos E, Sandoval Hernández A, Tecalco Cruz A. Differential expression and molecular interactions of chromosome region maintenance 1 and calreticulin exportins in breast cancer cells. J Steroid Biochem Mol Biol. 2019;185:7-16 pubmed publisher
    ..First, we showed an interaction between CRM-1 and CALR, and then we identified that SUN1 and SUN2, two proteins localized in the nuclear envelop, were able to interact specifically with CRM-1, but not CALR...
  49. Thakar K, May C, Rogers A, Carroll C. Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA. Mol Biol Cell. 2017;28:182-191 pubmed publisher
    ..Specifically, we find that LINC complexes that contain the inner nuclear membrane protein Sun2 promote focal adhesion assembly by activating the small GTPase RhoA...
  50. Shen S, Tobery C, Rose M. Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion. Mol Biol Cell. 2009;20:2438-50 pubmed publisher
    ..Genetic analysis, colocalization, and biochemical experiments indicate that Prm3p interacts directly with Kar5p, suggesting that nuclear membrane fusion is mediated by a protein complex. ..
  51. Lin S, Zhang L, Lin X, Zhang L, Garcia V, Tsai C, et al. Nuclear envelope protein MAN1 regulates clock through BMAL1. elife. 2014;3:e02981 pubmed publisher
    ..Our results establish a novel connection between the nuclear periphery and circadian rhythmicity, therefore bridging two global regulatory systems that modulate all aspects of bodily functions. ..
  52. Park C, Ryu H, Kim S, Lee D, Song H, Kim K. Presumed pseudokinase VRK3 functions as a BAF kinase. Biochim Biophys Acta. 2015;1853:1738-48 pubmed publisher
    ..Here, we demonstrate that VRK3 phosphorylates the nuclear envelope protein barrier-to-autointegration factor (BAF) on Ser4...
  53. Stewart R, Zubek A, Rosowski K, Schreiner S, Horsley V, King M. Nuclear-cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions. J Cell Biol. 2015;209:403-18 pubmed publisher
    ..In this paper, we demonstrate that the LINC complex component SUN2 contributes to the mechanical integrity of intercellular adhesions between mammalian epidermal keratinocytes...
  54. Matsumoto A, Hieda M, Yokoyama Y, Nishioka Y, Yoshidome K, Tsujimoto M, et al. Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer. Cancer Med. 2015;4:1547-57 pubmed publisher
    ..The linker of nucleoskeleton and cytoskeleton (LINC) complex, a nuclear envelope protein complex consisting mainly of the SUN and nesprin proteins, connects nuclear lamina and cytoskeletal ..
  55. Algahtani H, Marzouk Y, Algahtani R, Salman S, Shirah B. Autosomal Recessive Cerebellar Ataxia type 1 mimicking multiple sclerosis: A report of two siblings with a novel mutation in SYNE1 gene in a Saudi family. J Neurol Sci. 2017;372:97-100 pubmed publisher
    ..A mutation in the synaptic nuclear envelope protein 1 (SYNE1) gene that is located on chromosome 6p25 results in premature termination of the protein...
  56. Smith E, Meng Y, Moore R, Tse J, Xu A, Xu X. Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression. BMC Cell Biol. 2017;18:8 pubmed publisher
    ..We established ES cells genetically null for the nuclear lamina proteins lamin A/C or the inner nuclear envelope protein emerin, or compound mutant for both lamin A/C and emerin...
  57. Shang Y, Yan J, Tang W, Liu C, Xiao S, Guo Y, et al. Mechanistic insights into acephalic spermatozoa syndrome-associated mutations in the human SUN5 gene. J Biol Chem. 2018;293:2395-2407 pubmed publisher
    ..associated with this syndrome encodes Sad1 and UNC84 domain-containing 5 (SUN5), a testis-specific nuclear envelope protein. The functional role of SUN5 has been well-studied in mouse models, but the molecular basis for the ..
  58. Toribio Fernández R, Zorita V, Rocha Perugini V, Iborra S, Martinez del Hoyo G, Chevre R, et al. Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major. Cell Death Dis. 2018;9:9 pubmed publisher
    ..The nuclear envelope protein lamin A/C is induced in naive CD4+ T-cells upon antigen recognition and acts as a link between ..
  59. Jahed Z, Fadavi D, Vu U, Asgari E, Luxton G, Mofrad M. Molecular Insights into the Mechanisms of SUN1 Oligomerization in the Nuclear Envelope. Biophys J. 2018;114:1190-1203 pubmed publisher
    ..Most extensively studied are SUN1 and SUN2 proteins, which are widely expressed in mammals...
  60. WASSON L, Amin N, Conlon F. INTACT Proteomics in Xenopus. Cold Spring Harb Protoc. 2018;: pubmed publisher
    ..INTACT protocol utilizes two transgenes: (1) a three-part nuclear targeting fusion (NTF) consisting of a nuclear envelope protein (Nup35) that targets the NTF to the nuclear membrane, an enhanced green fluorescent protein (EGFP) ..
  61. Zhao Y, Cao H, Song Y, Feng Y, Ding X, Pang M, et al. Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system. Int J Mol Med. 2016;37:1511-20 pubmed publisher
    ..heterogeneity; pathogenic mutations in cardiac sarcomere protein genes, cytoskeletal protein genes and nuclear envelope protein genes have been linked to its etiology...
  62. Lange J, Metzner C, Richter S, Schneider W, Spermann M, Kolb T, et al. Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions. Biophys J. 2017;112:1472-1480 pubmed publisher
    ..simultaneously measure cell mechanics and fluorescence signals of cells that overexpress the GFP-tagged nuclear envelope protein lamin A...
  63. Potter C, Zhu W, Razafsky D, Ruzycki P, Kolesnikov A, Doggett T, et al. Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets. Curr Biol. 2017;27:2014-2022.e6 pubmed publisher
    ..recruits Nesprin1? at the ciliary rootlets of photoreceptors and identify asymmetric NE aggregates of Nesprin1? and Sun2 that dock filaments of rootletin at the nuclear surface...
  64. Bhargava A, Lahaye X, Manel N. Let me in: Control of HIV nuclear entry at the nuclear envelope. Cytokine Growth Factor Rev. 2018;40:59-67 pubmed publisher
    ..the viral capsid, integrase, the central viral DNA flap, and the host proteins CPSF6, TNPO3, Nucleoporins, SUN1, SUN2, Cyclophilin A and MX2...
  65. Hennen J, Angert I, Hur K, Gant Luxton G, MUELLER J. Investigating LINC Complex Protein Homo-oligomerization in the Nuclear Envelopes of Living Cells Using Fluorescence Fluctuation Spectroscopy. Methods Mol Biol. 2018;1840:121-135 pubmed publisher
    ..Since the homo-oligomerization of SUN2 is critical for its ability to interact with nesprins within the perinuclear space, the knowledge obtained through ..
  66. Varas J, Graumann K, Osman K, Pradillo M, Evans D, Santos J, et al. Absence of SUN1 and SUN2 proteins in Arabidopsis thaliana leads to a delay in meiotic progression and defects in synapsis and recombination. Plant J. 2015;81:329-46 pubmed publisher
    ..We propose that in Arabidopsis thaliana, overlapping functions of SUN1 and SUN2 ensure normal meiotic recombination and synapsis.
  67. Hantan D, Yamamoto Y, Sakisaka T. VAP-B binds to Rab3GAP1 at the ER: its implication in nuclear envelope formation through the ER-Golgi intermediate compartment. Kobe J Med Sci. 2014;60:E48-56 pubmed
    ..Recently, VAP-B has been shown to regulate the nuclear envelope protein transport through the ER-Golgi intermediate compartment (ERGIC)...
  68. Wang J, Yu I, Huang C, Chen C, Wang W, Lin S, et al. Sun1 deficiency leads to cerebellar ataxia in mice. Dis Model Mech. 2015;8:957-67 pubmed publisher
    ..Here, we report an unrecognized contribution of Sun1 and Sun2 to the postnatal development of murine cerebellum...
  69. Nie S, Ke H, Gao F, Ren J, Wang M, Huo L, et al. Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators. Structure. 2016;24:80-91 pubmed publisher
    ..Here, we found that the two coiled-coil domains (CC1 and CC2) of SUN2 exhibit distinct oligomeric states. CC2 is a monomer in solution...
  70. Lahaye X, Satoh T, Gentili M, Cerboni S, Silvin A, Conrad C, et al. Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication. Cell Rep. 2016;15:879-892 pubmed publisher
    ..Importantly, the inner nuclear envelope protein SUN2 is required for the antiviral activity of CypA...
  71. Sharp S, Lange J, Kandaswamy R, Daher M, Anjorin A, Bass N, et al. Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder. Psychiatr Genet. 2017;27:81-88 pubmed publisher
    ..SYNE1 encodes the synaptic nuclear envelope protein-1, nesprin-1...
  72. Bermeo S, Al Saedi A, Kassem M, Vidal C, Duque G. The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation. J Cell Biochem. 2017;118:4425-4435 pubmed publisher
    ..These effects could have an important role in the understanding of the role of the proteins of the nuclear envelope in bone formation. J. Cell. Biochem. 118: 4425-4435, 2017. © 2017 Wiley Periodicals, Inc. ..
  73. Sun W, Jiao S, Sun L, Zhou Z, Jin X, Wang J. SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin. MBio. 2018;9: pubmed publisher
    ..Here we revealed that "Sad1 and UNC84 domain containing 2" (SUN2), an inner nuclear membrane protein, maintained the repressive chromatin and inhibited HIV LTR-driven transcription ..
  74. Singh M, Jamal F, Dubey A, Shivam P, Kumari S, Pushpanjali -, et al. Visceral leishmaniasis: A novel nuclear envelope protein 'nucleoporins-93 (NUP-93)' from Leishmania donovani prompts macrophage signaling for T-cell activation towards host protective immune response. Cytokine. 2019;113:200-215 pubmed publisher
    ..This study reported that rLd-NUP93 was an effective immunoprophylactic agent that can be explored in future vaccine design. ..
  75. Donahue D, Porrot F, Couespel N, Schwartz O. SUN2 Silencing Impairs CD4 T Cell Proliferation and Alters Sensitivity to HIV-1 Infection Independently of Cyclophilin A. J Virol. 2017;91: pubmed publisher
    ..We previously reported that the overexpression of SUN2, an inner nuclear membrane protein and LINC complex component, inhibits HIV infection between the steps of reverse ..
  76. Jafferali M, Figueroa R, Hasan M, Hallberg E. Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Sci Rep. 2017;7:16655 pubmed publisher
    ..We have investigated Samp1 (Spindle Associated Membrane Protein 1), a transmembrane nuclear envelope protein, which interacts with emerin and lamin A, both of which are linked to Emery-Dreifuss muscular dystrophy (..
  77. Zhou X, Tamura K, Graumann K, Meier I. Exploring the Protein Composition of the Plant Nuclear Envelope. Methods Mol Biol. 2016;1411:45-65 pubmed publisher
    ..Here, we describe these methods for the example of Arabidopsis thaliana nuclear pore and nuclear envelope protein identification.
  78. Cerhan J, Ansell S, Fredericksen Z, Kay N, Liebow M, Call T, et al. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. Blood. 2007;110:4455-63 pubmed
    ..52-0.85), TLR6 V427A (OR = 5.20; CI 1.77-15.3), SELPLG M264V (OR = 3.20; CI 1.48-6.91), UNC84B G671S (OR = 1.50; CI 1.12-2.00), B3GNT3 H328R (OR = 0.74; CI 0.59-0.93), and BAT2 V1883L (OR = 0.64; CI 0.45-0.90)...
  79. Turgay Y, Champion L, Balázs C, Held M, Toso A, Gerlich D, et al. SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown. J Cell Biol. 2014;204:1099-109 pubmed publisher
    ..Our analysis demonstrates that simultaneous depletion of human SUN1 and SUN2 delayed removal of membranes from chromatin during NE breakdown (NEBD) and impaired the formation of prophase NE ..
  80. Zhou C, Li C, Zhou B, Sun H, Koullourou V, Holt I, et al. Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis. Hum Mol Genet. 2017;26:2258-2276 pubmed publisher
    ..Expression of these mutants caused nuclear morphology defects and reduced lamin A/C and SUN2 staining at the NE. GST pull-down indicated that nesprin-1/lamin/SUN interactions were disrupted...
  81. Birendra Kc -, May D, Benson B, Kim D, Shivega W, Ali M, et al. VRK2A is an A-type lamin-dependent nuclear envelope kinase that phosphorylates BAF. Mol Biol Cell. 2017;28:2241-2250 pubmed publisher uncover new constituents of the inner nuclear membrane (INM) by comparative BioID analysis of lamin A, Sun2 and a minimal INM-targeting motif...
  82. Lv X, Liu L, Cheng C, Yu B, Xiong L, Hu K, et al. SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer. Sci Rep. 2015;5:17940 pubmed publisher
    b>SUN2, a key component of LINC (linker of nucleoskeleton and cytoskeleton) complex located at the inner nuclear membrane, plays unknown role in lung cancer...
  83. Chang W, Antoku S, Gundersen G. Wound-Healing Assays to Study Mechanisms of Nuclear Movement in Fibroblasts and Myoblasts. Methods Mol Biol. 2016;1411:255-67 pubmed publisher
    ..established before migration by the coupling of dorsal actin cables to the nuclear envelope through nesprin-2G and SUN2 linker of nucleoskeleton and cytoskeleton (LINC) complexes...
  84. Klupp B, Hellberg T, Granzow H, Franzke K, Dominguez Gonzalez B, Goodchild R, et al. Integrity of the Linker of Nucleoskeleton and Cytoskeleton Is Required for Efficient Herpesvirus Nuclear Egress. J Virol. 2017;91: pubmed publisher
    ..herpesvirus infection, we generated cell lines constitutively expressing dominant negative (dn) forms of SUN1 and SUN2. Ultrastructural analyses revealed a significant expansion of the PNS and the contiguous intracytoplasmic lumen, ..
  85. Schaller T, Bulli L, Pollpeter D, Betancor G, Kutzner J, Apolonia L, et al. Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection. J Virol. 2017;91: pubmed publisher
    ..We found that the integral transmembrane proteins SUN1/UNC84A and SUN2/UNC84B are potent or modest inhibitors of HIV-1 infection, respectively, and that suppression corresponds to defects in ..
  86. Meinke P, Mattioli E, Haque F, Antoku S, Columbaro M, Straatman K, et al. Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization. PLoS Genet. 2014;10:e1004605 pubmed publisher
    ..Using a candidate approach, we have identified putative disease-causing variants in the SUN1 and SUN2 genes, also encoding LINC complex components, in patients with EDMD and related myopathies...
  87. Obado S, Field M, Chait B, Rout M. High-Efficiency Isolation of Nuclear Envelope Protein Complexes from Trypanosomes. Methods Mol Biol. 2016;1411:67-80 pubmed publisher
    ..The method is inexpensive and potentially applicable to many organisms, providing fast access to functional information. ..
  88. Baumann M, Steichen Gersdorf E, Krabichler B, Petersen B, Weber U, Schmidt W, et al. Homozygous SYNE1 mutation causes congenital onset of muscular weakness with distal arthrogryposis: a genotype-phenotype correlation. Eur J Hum Genet. 2017;25:262-266 pubmed publisher
    The exceptionally large SYNE1 (spectrin repeat-containing nuclear envelope protein 1) gene encodes different nesprin-1 isoforms, which are differentially expressed in striated muscle and in cerebellar and cerebral neurons...
  89. Chaumet A, Wright G, Seet S, Tham K, Gounko N, Bard F. Nuclear envelope-associated endosomes deliver surface proteins to the nucleus. Nat Commun. 2015;6:8218 pubmed publisher
    ..RNAi screening further revealed that NAE-mediated transfer depends on the nuclear envelope proteins SUN1 and SUN2, as well as the Sec61 translocon complex...
  90. Xu Y, Li W, Ke H, Feng W. Structural conservation of the autoinhibitory domain in SUN proteins. Biochem Biophys Res Commun. 2018;496:1337-1343 pubmed publisher
    LINC complexes span across the nuclear envelope and are assembled by SUN and KASH proteins. SUN1 and SUN2 are the two most abundant SUN proteins in mammals...
  91. Grønborg M, Kristiansen T, Stensballe A, Andersen J, Ohara O, Mann M, et al. A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate. Mol Cell Proteomics. 2002;1:517-27 pubmed
    ..Our method should be applicable as a generic strategy for enrichment and identification of serine/threonine-phosphorylated substrates in signal transduction pathways. ..
  92. Zhu R, Antoku S, Gundersen G. Centrifugal Displacement of Nuclei Reveals Multiple LINC Complex Mechanisms for Homeostatic Nuclear Positioning. Curr Biol. 2017;27:3097-3110.e5 pubmed publisher
    ..Rearward recentering was actomyosin, nesprin-2G, and SUN2 dependent, whereas forward recentering was microtubule, dynein, nesprin-2G, and SUN1 dependent...